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Particularly Hazardous Substances (PHS)

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Particularly Hazardous Substances (PHS) Chemical Class Standard Operating Procedures Particularly Hazardous Substances (PHS) Print a copy and insert into your laboratory SOP binder. Department: Chemistry Date SOP was written: June 10, 2013 Date SOP was approved by PI/lab supervisor: Name: Richmond Sarpong Principal Investigator: Signature: ______________________________ Name: Rebecca Murphy Internal Lab Safety Coordinator or Lab Manager: Lab Phone: 510-643-2485 Office Phone: 510-642-6312 Name: Richmond Sarpong Emergency Contact: Phone Number: 626-644-2407 Latimer Hall: 834, 836, 837, 838, 839, 842, 847, 849, Location(s) covered by this SOP: 907 1. Purpose This SOP covers the precautions and safe handling procedures for the use of Particularly Hazardous Substances in the Sarpong group, which include the following chemicals and their uses: Chemical(s) Use(s) PHSs 1. Using Particularly Hazardous Substances as reagents. PHS solvents 2. Using Particularly Hazardous Substances as solvents in reactions, for extractions or cleaning glassware. PHS solvents 3. Using Particularly Hazardous Substances as solvents in column chromatography (CC) or thin layer chromatography (TLC). Sarpong inventory chemicals See below. covered by this SOP Rev. Date: June 10, 2013 1 Particularly Hazardous Substances Class SOP Sarpong Group inventory chemicals covered by this SOP (R)-(+)-2,3-Dihydroindole-2-carboxylic acid Chloroform (r)-styrene oxide cis-1,4-Dichloro-2-butene (S)-(-)-Indoline-2-carboxylic acid Cobalt chloride hexahydrate 1,1,3,3-Tetramethylurea Cobalt(II) acetylacetonate 1,2,4-Triazole Cyclopropylboronic acid 1,2-bis(diphenylphosphino)ethane nickel (ii) chloride Diethyl azodicarboxylate 1,2-dichloroethane Diethylene glycol dimethyl ether 1,2-Epoxy-5-hexene epichlorohydrin 1,2-phenylenediamine Ethoxyethyne 1,3,5-trioxane Ethylhydrazine oxalate 1,3-Bis(diphenylphosphino)propanenickel(II) chloride Formamide 1,3-diphenylguanidine Gallium(III) Iodide 1,3-Phenylenediamine Glufosinate Ammonium 1,4-cyclohexanediene Glyoxal 1-bromo-2-chloroethane Haloperidol 1-Methyl-2-pyrrolidinone hexamethylphosphoramide 2,3-dichloro-1-propene Hexamethylphosphorous triamide 2,4-dinitrobenzenesulfonyl chloride Hexane 2-aminophenol Hydrazine hydrate 2-bromopropane hydrazine monohydrate 2-Methoxyethanol Hydroquinone 2-methyl-5-nitroaniline imidazole 2-Nitropropane Indium (III) iodide 2-nitrotoluene Isobutyl nitrite 4,4'-bis(dimethylamino)benzophenone isoprene 4,4'-dibromobiphenyl Lead (II) bromide 4-chloroaniline Lead (IV) acetate 5-Bromoisatoic anhydride Lithium acetylacetonate 5-methylfurfural Magnesium methyl carbonate 9-BBN triflate solution 0.5 M in hexanes N,N-Dimethylacetamide acrylamide Naphthalene allyl chloride Nickel (II) acetylacetonate aniline Nickel (II) sulfate hexahydrate aniline hydrochloride Nickel(II) chloride Benzamide nickel(II) iodide Benzyl Chloromethyl Ether Nickel(II)Chloride Hexahydrate bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphatenitrobenzene bis(triphenylphosphine)nickel(ii) chloride N-methylacetamide boric acid o-Aminoanisole Carbon Disulfide o-Phenylenediamine chloramphenicol Phenol Rev. Date: June 10, 2013 2 Particularly Hazardous Substances Class SOP Phenolphthalein Sodium dichromate dihydrate (VI) Phenylhydrazine hydrochloride Potassium dichromate Phenylhydrazine (Trimethylsilyl)diazomethane, 2M in diethyl ether phloroglucinol 1,1,2,2-Tetrachloroethane Propylene oxide 1,1,3,3-Propanetetracarbonitrile Pyridinium chlorochromate 1,2,4-trifluoro-5-nitrobenzene Pyrogallol 1,2-Ethanedithiol quinoline 1,3-diaminopropane Sodium Perborate Monohydrate 1,3-Dichloroacetone sodium tetraborate 1,3-Dicyclohexylcarbodiimide Styrene Oxide 1,3-diisopropylcarbodiimide Tebbe reagent 1,4-naphthoquinone Thiourea 1,5-Difluoro-2,4-dinitrobenzene trimethylphosphine 1M in toluene 12-Crown-4 Tris(2-methoxyethoxy)(vinyl)silane 1-cyanovinyl acetate Vinyl bromide 2,4,6-Trimethylaniline vinyl bromide, 1.0M in THF 2,4-dichlorophenol Vitride(R) T reducing agent 2,6-dibromopyridine chromium (VI) oxide 2-acetylfuran 1,1-Dimethylhydrazine 2-Acetylthiophene 2,4-Dinitroaniline 2-amino-6-picoline 2-chloroacrylonitrile 2-Bromo-5-(trifluoromethyl)pyridine 4-aminophenol 2-bromopyridine benzenethiol 2-chlorobenzyl chloride Benzyl chloride 2-chloroethanol benzyl chloroformate 2-chloropyridine Boron tribromide 2-Cyclohexen-1-one boron tribromide 1 M in DCM 2-Cyclohexenone cis-dichlorodiamine platinum(II) 2-ethylacrolein Cycloheximide 2-Ethylpropenal cyclohexylamine 2-furaldehyde Dimethylcarbamyl chloride 2-mercaptoethanol dimethyl sulfate 2-Pyridinecarboxaldehyde N,N-Dimethylsulfamoylchloride 3,4-diaminopyridine Di-n-butyltin dichloride 3-butyn-2-ol Glutaraldehyde 3-Butyn-2-one hexafluoroacetone 3-chlorophenyl isocyanate Hexafluoroacetone trihydrate 3-chloropropionyl chloride Hydrazine 4-(Dimethylamino)pyridine isopropyl chloroformate (1M in toluene) 4-Chlorobutanyryl chloride mercury bichloride 4-Methoxy-2-nitroaniline o-Tolidine dihydrochloride 5-chloro-2-nitroaniline Rev. Date: June 10, 2013 3 Particularly Hazardous Substances Class SOP Acetic Acid Triethylamine 2 M 2 M hydrazine sulfate acetone cyanohydrin Hydrogen fluoride pyridine Acetylferrocene Iodomethane Aconitine iron(0) pentacarbonyl adiponitrile isobutyronitrile allyl acetate isopropyl isocyanate allyl alcohol Malononitrile allyl chloroformate mercuric cyanide allyl iodide Mercuric oxide yellow allylamine Mercury (II) oxide benzeneseleninic anhydride mercury (II) sulfate Benzoyl cyanide Mercury iodide benzyl mercaptan mercury(ii) acetate Benzyltriphenylphosphonium chloride mercury(ii) trifluoroacetate Bis(4-nitrophenyl) hydrogenphosphate methanesulfonyl chloride Boron Trifluoride Ether Complex Methyl cyanoformate bromoacetaldehyde diethyl acetal methyl vinyl ketone Bromoacetic Acid methylphosphonic dichloride Butyl isocyanate molybdenum carbonyl Cesium azide m-xylylenediamine Cetylpyridinium chloride n,n'-dicyclohexylcarbodiimide chloroacetaldehyde N,N'-diisopropylcarbodiimide chloroacetone N,N-dimethyl-1,3-propanediamine chloroacetonitrile N,N-Dimethylphenylenediamine Cumene Hydroperoxide o-cresol cyanuric chloride Osmium Tetroxide cyclohexyl isocyanate Osmium tetroxide Solution Cyclopentanamine p-Anisidine Decaborane p-Cresol Dibutyl tin dilaurate p-Dinitrobenzene Dibutyltin(IV) Oxide phenyl chloroformate dichlorodiphenylsilane phenyl isocyanate diethyl chlorophosphate Phosphorus oxychloride Dimethylchloro phosphate Phosphorus pentachloride Dimethyldicarbonate phosphorus pentoxide Di-t-butyldicarbonate phosphorus trichloride (2.0 m in dcm) Eaton's reagent Phthalonitrile ethyl bromoacetate Pivaloyl chloride Ethyl chloroformate Propargyl Alcohol ethyl iodoacetate Propionitrile Ethylphosphonic dichloride pyridine-2-carboxaldehyde Hexamethylditin Selenium Rev. Date: June 10, 2013 4 Particularly Hazardous Substances Class SOP sodium borate Trimethyl(phenyl)tin Sodium cyanoborohydride Trimethylsilyl cyanide sodium tetraborate decahydrate Trimethylsilyldiazomethane Sodium Trifluoroacetate Trimethylsilyldiazomethane (2.0 M in hexanes) Strychnine Trimethylsilyldiazomethane, 2.0 M solution in hexanes sulfuryl chloride Trimethyltin azide Tetrabutylammonium cyanide Trimethyltin chloride tetramethyltin Triphosgene Tetranitromethane 1,2-dibromoethane thallium(I) carbonate Chloroform-D Thallium(I) ethoxide Pyridinium dichromate Thallium(III) acetate N-Nitroso-N-Methylurea thallium(III) nitrate trihydrate 4-Toluenesulfonyl azide thioglycolic acid Sodium perborate tetrahydrate Titanium tetrachloride tert-butyl hydroperoxide trans-crotonaldehyde 1,3-Dinitrobenzene Tributylamine peracetic acid 32 wt % in dilute acetic acid Trichloroacetyl chloride 4-dimethylaminopyridine Triethoxysilane Nickel peroxide Trimethyl acetyl chloride Rev. Date: June 10, 2013 5 Particularly Hazardous Substances Class SOP 2. Physical & Chemical Properties/Definition of Chemical Group Particularly Hazardous Substances fall into three major categories: reproductive toxins, acute toxins, and select carcinogens. Reproductive Toxins are chemicals that affect the reproductive capabilities including causing chromosomal damage (mutations) and adverse effects on fetal development (teratogenesis). Reproductive toxins are designated by one or more of the following H codes: H340 May cause genetic defects H341 Suspected of causing genetic defects H360 May damage fertility or the unborn child H361 Suspected of damaging fertility or the unborn child H362 May cause harm to breast-fed children Acute Toxins are chemicals that pose a high level of immediate health risk to individuals. Acutely Toxic Chemicals are those listed specifically in the Settlement Agreement and/or those chemical compounds with a high level of acute toxicity as defined by the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) Categories 1 and 2: Acute Toxicity Category 1 Category 2 Oral (mg/kg) < 5 Between > 5 and ≤ 50 Dermal (mg/kg) < 50 Between > 50 and ≤ 200 Gases (ppm) < 100 Between > 100 and ≤ 500 Vapors (mg/l) < 0.5 Between > 0.5 and ≤ 2.0 Dusts and Mists (mg/l) < 0.05 Between > 0.05 and ≤ 0.5 Acutely toxic chemicals may also have other hazardous properties in addition to acute toxicity. Safe use requires assessing all potential hazards. Acutely toxic chemicals are designated by one or more of the following H codes: H300 Fatal if swallowed H310 Fatal in contact with skin H330 Fatal if inhaled Select Carcinogens are a category of chemicals where the available evidence strongly indicates that the substances cause human carcinogenicity. A “select carcinogen” meets one of the following criteria.
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