UC San Diego UC San Diego Previously Published Works Title Differential effects of bicarbonate on severe hypoxia- and hypercapnia-induced cardiac malfunctions in diverse fish species. Permalink https://escholarship.org/uc/item/8p99n97z Journal Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 191(1) ISSN 0174-1578 Authors Lo, Mandy Shahriari, Arash Roa, Jinae N et al. Publication Date 2021 DOI 10.1007/s00360-020-01324-y Peer reviewed eScholarship.org Powered by the California Digital Library University of California 1 Differential effects of bicarbonate on severe hypoxia- and hypercapnia-induced cardiac 2 malfunctions in diverse fish species 3 4 Mandy Lo1, Arash Shahriari1, Jinae N. Roa2, Martin Tresguerres2, Anthony P. Farrell1,3 5 6 7 1Department of Zoology, University of British Columbia, 6270 University Boulevard, 8 Vancouver, British Columbia, Canada V6T 1Z4 9 10 2Marine Biology Research Division, Scripps Institution of Oceanography, University of 11 California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA 12 13 3Faculty of Land and Food Systems, University of British Columbia, 2357 Main Mall, 14 Vancouver, British Columbia, Canada V6T 1Z4 15 16 M. Lo (corresponding author) 17 Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, 18 British Columbia, Canada V6T 1Z4 19 Email:
[email protected] 20 21 22 23 1 24 Abstract 25 We tested in six fish species [Pacific lamprey (Lampetra richardsoni), Pacific spiny dogfish 26 (Squalus suckleyi), Asian swamp eel (Monopterus albus), white sturgeon (Acipenser 27 transmontanus), zebrafish (Danio rerio), and starry flounder (Platichthys stellatus)] the - 28 hypothesis that elevated extracellular [HCO3 ] protects spontaneous heart rate and cardiac force 29 development from the known impairments that severe hypoxia and hypercapnic acidosis can 30 induce.