SRBR 2012 Program

Total Page:16

File Type:pdf, Size:1020Kb

SRBR 2012 Program SRBR 2012 Program Saturday, May 19, 2012 9:00-5:00 PM Trainee Professional Development Day 7:00-9:00 PM Opening Reception * Grand Lawn Sunday, May 20, 2012 8:15-10:00 AM Symposium 1: Signal Integration In Circadian Neural Networks Chair: Sato Honma, Hokkaido University Speakers: David Welsh, University of California, San Diego Elizabeth Maywood, MRC Laboratory of Molecular Biology, Cambridge Mark Zoran, Texas A&M University Paul Taghert, Washington University Medical School Symposium 2: Translational Chronobiology Chair: Francis Levi, INSERM Speakers: Karla Allebrandt, Ludwig-Maximilians-University of Munich Steven Brown, University of Zurich Pasquale Innominato, INSERM Francesco Benedetti, University of Modena Symposium 3: The Molecular Clockworks Chair: Luis Larrondo, P. Universidad Catolica de Chile Speakers: Paul Hardin, Texas A&M University Felix Naef, Ecole Polytechique Federale de Lausanne Steve Kay, University of California, San Diego Michael Brunner, Heidelburg University 11:00 – 12:30 PM Slide Session A 12:30 – 4:15 PM Free Time, Workshops 4:15 – 6:30 PM Symposium 4: New Discoveries in the TTFL Chair: Yi Liu, UT Southwestern Medical Center Speakers: Ueli Schibler, University of Geneva Ravi Allada, Northwestern University Joanna Chiu, University of California, Davis David Somers,,Ohio State University/POSTECH Symposium 5: Time to Sleep Chair: Valérie Mongrain, University of Montreal and CARSM Speakers: Michael Nitabach, Yale School of Medicine Paul Franken, University of Lausanne Helen Burgess, Rush University Medical Center Diane Boivin, McGill University Symposium 6: Circadian Rhythms in the Wild Chair: Heiko Jansen, Washington State University Speakers: Brian Barnes, University of Alaska Noga Kronfeld-Schor, Tel Aviv University Rudolfo Costa, University of Padova Paul Bartell, Pennsylvania State University 8:00-9:00 PM Data Blitz 8:30-10:30 PM Poster Session I Monday, May 21, 2012 8:15-10:30 AM Symposium 7: Circadian Output Mechanisms and Networks Chair: Jennifer Loros, Dartmouth Medical School Speakers: John Hogenesch, University of Pennsylvania Jay Dunlap, Dartmouth Medical School Toru Takumi, Hiroshima University Stacey Harmer, University of California, Davis Symposium 8: Integration Between the Circadian Clock and Metabolism Chair: Akhilesh Reddy, University of Cambridge Speakers: Carla Green, UT Southwestern Amita Seghal, HHMI/UPerelman School of Medicine, University of Pennsylvania Frédéric Gachon, University of Lusanne Jonathan Johnston, University of Surrey Symposium 9: Cross-talk Between the Circadian Clock and the Immune System Chair: Nicolas Cermakian, McGill University Speakers: Diego Golombek, National University of Quilmes Shigenobu Shibata, Waseda University Dipak Sarkar, Rutgers University Tanja Lange, University of Lübeck 11:00 – 12:30 PM Slide Session B 12:30 – 4:30 PM Free Time, Workshops 4:30 – 6:30 PM Presidential Special Symposium: “Time, Sleep, and Memory” Chair: Michael Hastings Speakers: Steve Reppert, University of Massachusetts Medical School Matt Wilson, Massachusetts Institute of Technology Craig Heller, Stanford University 8:30 – 10:30 PM Poster Session II Tuesday, May 22, 2012 8:15-10:30 AM Symposium 10: Entrainment and Masking: Function and Mechanisms Chair: Martha Merrow, University of Munich Speakers: Carl Johnson, Vanderbilt University Yi Liu, UT Southwestern Medical Center Charalambos Kyriacou, University of Leicester Elizabeth Klerman, Brigham and Women’s Hospital/Harvard Medical School Symposium 11: Posttranslational Oscillators Chair: Susan Golden, University of California, San Diego Speakers: Andy LiWang, University of California, Merced Katja Lamia, The Scripps Research Institute John O’Neill, University of Cambridge Gerben van Ooijen, University of Edinburgh Symposium 12: Circadian Rhythms and Disease Chair: Marina Antoch, Roswell Park Cancer Institute Speakers: R. Daniel Rudic, Georgia Health Sciences University Chris Colwell, UCLA Medical School Roman Kondratov, Cleveland State University Stephanie Perreau-Lenz, Central Institute of Mental Health 11:00 – 12:30 PM Slide Session C 12:30 – 4:15 PM Free Time, Workshops 4:15 – 6:30 PM Symposium 13: Circadian Chromatin Remodeling Chair: C. Robertson McClung, Dartmouth College Speakers: Paolo Sassone-Corsi, University of California, Irvine Chuck Weitz, Harvard Medical School Paloma Mas, Instituto de Biología Molecular de Barcelona William Belden, Rutgers Symposium 14: Circadian Organization and Peripheral Oscillators Chair: Anne Eckert, University of Basel Speakers: Vincent Cassone, University of Kentucky Michael Menaker, University of Virginia Shin Yamazaki, Vanderbilt University Nick Foulkes, Max Plank Institute Symposium 15: The Circadian Clock in Fitness and Aging Chair: Jadwiga Giebultowicz, Oregon State University Speakers: Scott Pletcher, University of Michigan Medical School Karyn Esser, University of Kentucky Roxanne Sterniczuk, Dalhousie University Jeanne Duffy, Brigham and Women’s Hospital,Harvard Medical School 8:00 – 10:30 PM Poster Session III Wednesday, May 23, 2012 8:15-10:30 AM Symposium 16: The Importance of Being Entrained Chair: Satchin Panda, Salk Institute Speakers: Michael Gorman, University of California, San Diego Takashi Yoshimura, Nagoya University Susan Golden, University of California, San Diego Robert Lucas, University of Manchester Symposium 17: From Computer to Bench Chair: Danny Forger, University of Michigan Speakers: Christian Hong, University of Cincinnati College of Medicine/ Attila Csikasz- Nagy, University of Trento Achim Kramer, University of Berlin / Hanspeter Herzel, University of Berlin Hiroki Ueda, RIKEN / Ricuhiro Yamada, National Cancer Center Hospital, RIKEN Mino Belle, University of Manchester /Casey Diekman, Mathematical Biosciences Institute Symposium 18: New Developments in Cognitive Chronobiology Chair: Katherine Sharkey, Brown University Speakers: Derk-Jan Dijk, University of Surrey Pierre Maquet, University of Liege Christian Cajochen, University of Basel Kenneth Wright, University of Colorado 11:00 – 12:30 PM Slide Session D 12:30 – 4:00 PM Free Time, Workshops 4:00 – 5:00 PM Business Meeting –Survey 5:30 – 6:30 PM Pittendrigh/Aschoff Lecture Introduction: Fred Turek, Northwestern University Speaker: Joe Takahashi, UT Southwestern 7:00 – 8:00 PM Cocktail Reception 8:00 – 11:00 PM Closing Banquet .
Recommended publications
  • Faculty Mentor List Basic Science Faculty Mentors 1. Joseph
    Faculty Mentor List Basic Science faculty mentors 1. Joseph Takahashi, Ph.D. Professor and Chair, Department of Neuroscience [email protected] Research Statement: The long-term goals of the Takahashi laboratory are to understand the molecular and genetic basis of circadian rhythms in mammals and to utilize forward genetic approaches in the mouse as a tool for gene discovery for complex behavior. We have focused our attention in three areas: 1) identification of circadian clock genes and assignment of their function in the molecular mechanism of the circadian pacemaker; 2) analysis of central and peripheral circadian oscillators using real-time circadian reporters; and 3) identification of genes defined by mutations isolated in the large-scale mutagenesis screens we have conducted on neural and behavioral phenotypes including psychostimulant responses and contextual and cue dependent fear conditioning. Recently, we have focused on the structural biology of circadian clock proteins and on genomewide analysis of transcription factor binding and gene expression using next generation sequencing methods. A comprehensive global analysis of circadian transcription factor binding in the mouse liver has been completed in which all core components of the clock gene pathway have been interrogated. In addition, we have also analyzed the genome-wide regulation of nascent transcription, RNA polymerase II occupancy and epigenomic regulation of chromatin by the circadian clock. We have recently identified genes involved in cocaine responsiveness using forward genetic approaches. My laboratory has demonstrated a successful record of research productivity and training in circadian biology, mammalian genetics, genomics and molecular biology. 1. Huang, N, Y Chelliah, Y Shan, CA Taylor, S-H Yoo, C Partch, CB Green, H Zhang, JS Takahashi 2012 Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
    [Show full text]
  • CURRICULUM VITAE Joseph S. Takahashi Howard Hughes Medical
    CURRICULUM VITAE Joseph S. Takahashi Howard Hughes Medical Institute Department of Neuroscience University of Texas Southwestern Medical Center 5323 Harry Hines Blvd., NA4.118 Dallas, Texas 75390-9111 (214) 648-1876, FAX (214) 648-1801 Email: [email protected] DATE OF BIRTH: December 16, 1951 NATIONALITY: U.S. Citizen by birth EDUCATION: 1981-1983 Pharmacology Research Associate Training Program, National Institute of General Medical Sciences, Laboratory of Clinical Sciences and Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD 1979-1981 Ph.D., Institute of Neuroscience, Department of Biology, University of Oregon, Eugene, Oregon, Dr. Michael Menaker, Advisor. Summer 1977 Hopkins Marine Station, Stanford University, Pacific Grove, California 1975-1979 Department of Zoology, University of Texas, Austin, Texas 1970-1974 B.A. in Biology, Swarthmore College, Swarthmore, Pennsylvania PROFESSIONAL EXPERIENCE: 2013-present Principal Investigator, Satellite, International Institute for Integrative Sleep Medicine, World Premier International Research Center Initiative, University of Tsukuba, Japan 2009-present Professor and Chair, Department of Neuroscience, UT Southwestern Medical Center 2009-present Loyd B. Sands Distinguished Chair in Neuroscience, UT Southwestern 2009-present Investigator, Howard Hughes Medical Institute, UT Southwestern 2009-present Professor Emeritus of Neurobiology and Physiology, and Walter and Mary Elizabeth Glass Professor Emeritus in the Life Sciences, Northwestern University
    [Show full text]
  • Profile of Jay C. Dunlap
    PROFILE PROFILE Profile of Jay C. Dunlap Paul Gabrielsen Science Writer On moonless nights, the wakes of oceangoing back to oceanography,” Dunlap says, “but I boats sparkle with the blue bioluminescence just thought clocks were the greatest things of unicellular dinoflagellates. As a graduate I’deverheardabout.” He chose to attend student at Harvard University, Jay C. Dunlap Harvard. pondered the carefully orchestrated biological Dunlap found Hastings’ approach to his rhythms that direct dinoflagellates to produce students’ research to be supportive but hands light only at night. Dunlap, a student of off. “He provided all these resources,” Dunlap oceanography at the time, realized that the says, “but he never told people what to do. He field of biological rhythms was still a wide- would give you great feedback on what you open frontier, with many fundamental ques- were doing, but you needed to find your own tions yet to be answered. “This was a place,” way. And if you were lucky enough to do that, he says, “where I could make a mark.” then you really learned how to do science.” Dunlap, Nathan Smith Professor and Chair In 1977, Dunlap attended a 10-week of Genetics at Dartmouth’s Geisel School of summer course on biological rhythms at Medicine and a member of the National Hopkins Marine Station in Pacific Grove, Academy of Sciences since 2009, has devoted California organized by Colin Pittendrigh, his career to answering those fundamental who, along with Hastings, had made pio- questions. His work has uncovered how cir- neering advances in the field of rhythms. The cadian rhythms work at a genetic level, how course attracted scientists studying rhythms environmental cues, such as light, can set bi- along with their graduate students, who, ological clocks, and how the clock can regu- Dunlap says, composed an entire generation Jay C.
    [Show full text]
  • Crystal Structure of the Avirulence Gene Avrlm4-7 of Leptosphaeria Maculans. Illuminates Its Evolutionary and Functional Charact
    Crystal structure of the Avirulence Gene AvrLm4-7 of Leptosphaeria maculans. Illuminates its evolutionary and functional characteristics Isabelle Fudal, Francoise Blaise, K Blondeau, M. Graille, A. Labarde, A. Doisy, Bm Tyler, S.D. Kale, Guillaume Daverdin, Marie-Helene Balesdent, et al. To cite this version: Isabelle Fudal, Francoise Blaise, K Blondeau, M. Graille, A. Labarde, et al.. Crystal structure of the Avirulence Gene AvrLm4-7 of Leptosphaeria maculans. Illuminates its evolutionary and functional characteristics. 26. Fungal Genetics Conference at Asilomar, Mar 2011, Asilomar, United States. pp.234. hal-01000740 HAL Id: hal-01000740 https://hal.archives-ouvertes.fr/hal-01000740 Submitted on 6 Jun 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. 26th Fungal Genetics Conference at Asilomar March 15-20 2011 Principle Financial Sponsors Genetics Society of America Burroughs Wellcome Fund US National Institutes of Health Novozymes Great Lakes Bioenergy Research Center Konkuk University Bio Molecular Informatics Center Genencor, A Danisco Division
    [Show full text]
  • Abstracts from the Neurospora 2002 Conference
    Fungal Genetics Reports Volume 49 Article 13 Abstracts from the Neurospora 2002 conference Neurospora 2002 conference Follow this and additional works at: https://newprairiepress.org/fgr This work is licensed under a Creative Commons Attribution-Share Alike 4.0 License. Recommended Citation Neurospora 2002 conference. (2002) "Abstracts from the Neurospora 2002 conference," Fungal Genetics Reports: Vol. 49, Article 13. https://doi.org/10.4148/1941-4765.1195 This Supplementary Material is brought to you for free and open access by New Prairie Press. It has been accepted for inclusion in Fungal Genetics Reports by an authorized administrator of New Prairie Press. For more information, please contact [email protected]. Abstracts from the Neurospora 2002 conference Abstract Abstracts and Poster abstracts from the Neurospora 2002 conference This supplementary material is available in Fungal Genetics Reports: https://newprairiepress.org/fgr/vol49/iss1/13 : Abstracts from the Neurospora 2002 conference Neurospora 2002 Schedule March 14-17, 2002 Invited Abstracts Asilomar Conference Center Pacific Grove, CA. Poster Abstracts SCIENTIFIC PROGRAM Index Barry Bowman Gloria Turner Schedule of Activities Thursday, March 14 3:00 - 6:00 pm, Registration: Administration 6:00 - 7:00 pm, Dinner: Crocker 7:00 - 10:00 pm, Mixer: Kiln Friday, March 15 7:30 - 8:30 am, Breakfast, Crocker 8:30 - 12:00 Noon, Session I, Chapel Genomic Analysis : Mary Anne Nelson, Chair 8:35 - Bruce Birren, MIT, Whitehead Institute. "Genome sequencing for Neurospora crassa." 9:05 - Gertrud Mannhaupt, Heinrich-Heine-University. "The MIPS Neurospora crassa database- MNCDB." 9:30 - Chuck Staben, U. of Kentucky. "Gene finding and annotation for fungal genomes." 9:55 - Alan Radford, University of Leeds.
    [Show full text]
  • An Evolutionary Hotspot Defines Functional Differences Between
    ARTICLE DOI: 10.1038/s41467-018-03503-6 OPEN An evolutionary hotspot defines functional differences between CRYPTOCHROMES Clark Rosensweig1,6, Kimberly A. Reynolds2,3, Peng Gao1, Isara Laothamatas1, Yongli Shan1, Rama Ranganathan2,3,4,7, Joseph S. Takahashi 1,5 & Carla B. Green1 Mammalian circadian clocks are driven by a transcription/translation feedback loop com- posed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME 1/2 1234567890():,; (CRY1/2) and PER1/2). To understand the structural principles of regulation, we used evo- lutionary sequence analysis to identify co-evolving residues within the CRY/PHL protein family. Here we report the identification of an ancestral secondary cofactor-binding pocket as an interface in repressive CRYs, mediating regulation through direct interaction with CLOCK and BMAL1. Mutations weakening binding between CLOCK/BMAL1 and CRY1 lead to acceleration of the clock, suggesting that subtle sequence divergences at this site can modulate clock function. Divergence between CRY1 and CRY2 at this site results in distinct periodic output. Weaker interactions between CRY2 and CLOCK/BMAL1 at this pocket are strengthened by co-expression of PER2, suggesting that PER expression limits the length of the repressive phase in CRY2-driven rhythms. Overall, this work provides a model for the mechanism and evolutionary variation of clock regulatory mechanisms. 1 Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. 2 Department of Biophysics, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. 3 The Green Center for Systems Biology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.
    [Show full text]
  • Jay Dunlap KITP UC Santa Barbara July, 2007 Circadian
    The Neurospora Circadian System - some new tools and new insights Jay Dunlap KITP UC Santa Barbara July, 2007 Circadian. Systems in the Universal Tree of Life Brown Algae Ciliates PLANTAE Diatoms TetrahymenaExcellent genetics Arabidopsis Paramecium Chlamydomonas Tractable molecular genetics Dinoflagellates Insects - Antheraea, - genome of 43 Mb fully sequenced Drosophila Gonyaulax ANIMALIA ~10,000 genes annotated Mammals- - ongoing curation mouse, human FUNGI Neurospora - numerousBrown Algaeregulatable promoters Diatoms Ciliates Protista - targetedPLANTAE replacements @98% efficiency EUKARYOTA ~2500Sponges genes knockedDinoflagellates out + ~200/month Red Algae ANIMALIA Dictyostelium discoideum - wholeFUNGI genome microarrays Neurospora Entamoebae invadens Typical eukaryotic gene structureAmoebamastigote Plant Chloroplasts Synechococcus Mycoplasma-multiple introns Bodonids Cyanobacteria capricolum- combinatorial gene regulationKinetoplastids EUBACTERIA Euglenoids Physarum polycephalum Agrobacterium 28 cell types tumefaciens Plant Mitochondria Real world biology - photobiology Vairimorpha necatrix Pseudomonas testosteroni Trichomonas foetus - developmentGiardia lamblia Escherichia coli-cell/environmental interaction - circadian rhythms ARCHAEBACTERIA Dunlap, Cell, 1999 LIGHT P NeurosporaNeurosporaP P P LIGHTLIGHTLIGHT FRH FRQ P WC-2 WC-1LIGHT FRQ NucleusWC-1NucleusWC-2LightLIGHT - P P P Nucleus - WC-2PWC-2P WC-1 LIGHTP + ubiquitinationmodifications & by FRQFRQ WC-2 WC-1 modifications by WC-1P WC-2::WC-1 productsturnoverproducts of other
    [Show full text]
  • Neurospora 2018 OCTOBER 18-21 ASILOMAR CONFERENCE CENTER
    PROGRAM and ABSTRACTS Neurospora 2018 OCTOBER 18-21 ASILOMAR CONFERENCE CENTER PACIFIC GROVE CALIFORNIA Cover design by Stephanie Herzog, Technische Universität Braunschweig Neurospora 2018 October 18-21 Asilomar Conference Center Pacific Grove California Scientific Organizers André Fleißner Thomas M. Hammond Technische Universität Braunschweig Illinois State University Neurospora Policy Committee Barry Bowman Jason E. Stajich Molecular Cell & Developmental Biology Dept. Plant Pathology & Microbiology University of California - Santa Cruz University of California - Riverside André Fleißner Thomas M. Hammond Institut für Genetik School of Biological Sciences Technische Universität Braunschweig Illinois State University Brief Schedule Morning Afternoon Evening Thursday Arrival Dinner October 18 Registration Mixer (Heather) Breakfast Lunch Friday Plenary Session I Plenary Session II Dinner October 19 Cell Biology and Metabolism, Signaling and Poster Session Morphogenesis Development Breakfast Lunch Banquet Saturday Plenary Session III Plenary Session IV Speaker October 20 Gene Expression and Genomics, Evolution, and Poster Session Epigenetics Tools Breakfast Sunday Plenary Session V Lunch October 21 Circadian Clocks and Departure Environmental Sensing All Plenary Sessions will be held in Heather. Posters will be displayed in Heather and Toyon throughout the meeting. They should be set up Friday and displayed until the end of the poster session/reception on Saturday evening. Schedule of Activities Thursday, October 18 15:00 - 18:00 p.m. Registration:
    [Show full text]
  • A Fungus Amongst Us 7
    Curr. Issues Mol. Biol. 16: 7-8. A Fungus Amongst Us 7 Book review Neurospora: Genomics and Molecular Biology Durgadas P. Kasbekar and Kevin McCluskey (Eds.) Caister Academic Press (2013) ISBN: 978-1-908230-12-6 A Fungus Amongst Us Neurospora Genomics and Molecular Biology Neurospora Genomics and Molecular Biology Neurospora Building on over 70 years of genetics research, Neurospora continues to be the leading model for the study of the genomics and molecular biology of flamentous Genomics and Molecular Biology fungi. The ease of culture, amenability to genetic and molecular genetic analysis, and the close correlation between genetic and biochemical traits are some of its Jennifer Loros advantages. Research with Neurospora has provided insights unachievable from work with simpler systems and difcult to extract from more complicated ones, cementing its position as a leading model system. In recent years the application of modern high throughput analyses had led to a deluge of information on the Department of Biochemistry, Thegenomics andAudrey molecular biology and of Neurospora Theodor. This timely book aims to distil the most important fndings to provide a snapshot of the current research landscape. Geisel School of Medicine at InDartmouth this book, internationally recognizedHanover, Neurospora experts NH, critically review the most important research and demonstrate the breadth of applications to industrial USA biology, biofuels, agriculture, and human health. The opening chapter is an introduction to the organism. Following chapters cover topics such as: carotenoid biosynthesis, polysaccharide deconstruction, genome biology, genome recombination, gene regulation, signal transduction, self-recognition, development, circadian rhythms and mutation. The book closes with a fascinating look at the Durgadas Kasbekar and Kevinhistory and futureMcCluskey trends for research have edited on Neurospora gene and genome Kasbekar and McCluskey Kasbekar an engaging new book calledanalysis.
    [Show full text]
  • The Light Mutant Oscillator (Lmo): a Novel Circadian
    THE LIGHT MUTANT OSCILLATOR (LMO): A NOVEL CIRCADIAN OSCILLATOR IN NEUROSPORA CRASSA A Thesis by HE HUANG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August 2008 Major Subject: Biology THE LIGHT MUTANT OSCILLATOR (LMO): A NOVEL CIRCADIAN OSCILLATOR IN NEUROSPORA CRASSA A Thesis by HE HUANG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, Deborah Bell-Pedersen Committee Members, Daniel Ebbole Susan Golden Wayne Versaw Head of Department, Vincent Cassone August 2008 Major Subject: Biology iii ABSTRACT The Light Mutant Oscillator (LMO): A Novel Circadian Oscillator in Neurospora crassa. (August 2008) He Huang, B.Eng., Beijing University of Chemical Technology Chair of Advisory Committee: Dr. Deborah Bell-Pedersen Circadian clocks are present in most eukaryotes and some prokaryotes and control rhythms in behavior, physiology and gene expression. One well-characterized circadian clock is that of Neurospora crassa. In addition to the well-described N. crassa FRQ/WCC oscillator, several lines of evidence have implied the presence of other oscillators which may have important functions in the N. crassa circadian clock system. However, the molecular details are only known for the core FRQ/WCC oscillator. The light mutant oscillator (LMO) was identified by two mutations (LM-1 and LM-2) and shown to control developmental rhythms in constant light (LL), conditions in which the FRQ/WCC oscillator is not functional. The objective of this project was to determine whether the developmental rhythms driven by the LMO are circadian, whether the components of the LMO communicate with components of the FRQ/WCC oscillator, and to begin to define the molecular nature of the LMO.
    [Show full text]
  • Roedunet 2006
    Rhythmic Degradation Explains and Unifies Circadian Transcriptome and Proteome Data S. Lück1 2, K. Thurley1, P. F.Thaben1, P. O. Westermark1 In a second approach we expand the view on a molecule's Short Abstract — In many mammalian tissues, 10% of all life and include a measure of a molecule's age. We address transcripts display a 24-hour rhythm in abundance. These the question in which cases there is an advantage of abundane profiles are thought to be driven by the “circadian rhythmic instead of constant degradation of long-lived clock”, a regulatory network of transcription factors. proteins when they accumulate oxidative damage. Secondly, in a collaboration with Carla Green we use the same model Recent studies have uncovered that these transcripts to analyze sequencing data of poly(A) tails of mRNA in experience a widespread circadian post-transcriptional order to identify bottle necks in (rhythmic) mRNA regulation. Using an ODE-model with time-dependent rates degradation. we have recently shown that the assumption of rhythmic half- lives can explain the mismatch of measured peaks of pre- mRNA and mRNA. The model predicts that peak phases of ca. REFERENCES 30% of oscillatory mRNA in mouse liver and fly brain are determined by rhythmic degradation. An expansion to a PDE [1] Zhang EE, Kay SA (2010) “Clocks not winding down”, Nature 11 764- allows us to include a measure for the molecule's age, and thus 776 study oxidative protein damage or polyA-tail shortening. [2] Menet JS, et al. (2012) “Nascent-Seq reveals novel features of mouse circadian transcriptional regulation”, eLife 1:e0001 [3] Mauvoisin D, et al.
    [Show full text]
  • Agenda Final
    Janelia Farm Conference: Circadian Clocks: Mechanisms, Coordination, and Physiology Sunday, March 4th 3:00 pm Check-in 6:00 pm Reception (Lobby) 7:00 pm Dinner 8:00 pm Keynote Talk: Takao Kondo, Nagoya University Circadian pacemaker of cyanobacteria by intramolecular feedback of KaiC ATPase 9:00 pm Refreshments available at Bob’s Pub Updated 02/03/12 Janelia Farm Conference: Circadian Clocks: Mechanisms, Coordination, and Physiology Monday, March 5th 7:30 am Breakfast (service ends at 8:45 am) 9:00 am Session 1 Chair: Joe Takahashi 9:00 am Michael Brunner, University of Heidelberg A global transcription repressor links metabolism and the circadian clock of Neurospora 9:30 am Deborah Bell-Pedersen, Texas A&M University Global gene regulatory networks control circadian output in neurospora 10:00 am Jay Dunlap, Dartmouth Medical School Genetic and molecular dissection of the neurospora circadian oscillatory system 10:30 am Break 11:00 am Session 2 Chair: Martha Merrow 11:00 am Susan S. Golden, University of California, San Diego Signal transduction into and out of the cyanobacterial circadian oscillator 11:30 am Erin O'Shea, HHMI/Harvard University Timekeeping by a three-protein circadian clock 12:00 pm Andrew Oates, Max Planck Institute of Molecular Cell Biology and Genetics Mechanism and coordination of oscillating cells in the embryo's segmentation clock 12:30 pm Lunch 2:00 pm Session 3 Chair: Michael Rosbash 2:00 pm Steve A. Kay, University of California, San Diego Large scale discovery approaches to understanding circadian networks
    [Show full text]