Sir Joseph Barcroft C.B.E., M.A., D.Sc., Hon. M.D., Hon. F.R.C.O.G., F.R.S
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CHIST1 Joseph Barcroft.Pmd
Anales de la Facultad de MedicinaJoseph Barcroft y la expedición anglo-americana a los Andes Peruanos ISSN 1025 - 5583 Universidad Nacional Mayor de San Marcos Págs. 159-173 Historia Joseph Barcroft y la expedición anglo-americana a los Andes Peruanos (1921-1922) Oscar G. Pamo 1,2 Resumen Joseph Barcroft (1872-1947), fisiólogo británico de Cambridge, vino al Perú hacia fines de 1921 liderando la expedición angloamericana para estudiar las características fisiológicas que permiten a los humanos aclimatarse a la vida en las grandes alturas. Arribaron a Cerro de Pasco, realizando diversas mediciones y a diferentes altitudes, en ellos, en el personal norteamericano de la mina y en algunos nativos. Esta experiencia, publicada dos años más tarde, generaría en el doctor Carlos Monge Medrano (1884-1970) y otros investigadores nacionales el interés de conocer la biología y la patología del hombre andino, en 1927. Palabras clave Historia de la medicina, Perú; altitud; ecosistema andino; Barcroft, Joseph. Joseph Barcroft and the Anglo-American lideró la expedición angloamericana que a fines de 1921 expedition to the Peruvian Andes (1921-1922) vino a los Andes peruanos a estudiar la fisiología Abstract respiratoria del humano sometido a baja presión Joseph Barcroft (1872-1947), British Cambridge atmosférica. Sus conclusiones, que publicó dos años physiologist, came to Peru at the end of 1921 leading the después, dieron lugar a una respuesta del Dr. Carlos Monge Anglo-American expedition in order to study the Medrano en 1927. De allí en adelante, se realizó numerosas physiological characteristics that let human beings investigaciones para estudiar la salud y la enfermedad del acclimatize to live at high altitude environments. -
THE ETHICAL DILEMMA of SCIENCE and OTHER WRITINGS the Rockefeller Institute Press
THE ETHICAL DILEMMA OF SCIENCE AND OTHER WRITINGS The Rockefeller Institute Press IN ASSOCIATION WITH OXFORD UNIVERSITY PRESS NEW YORK 1960 @ 1960 BY THE ROCKEFELLER INSTITUTE PRESS ALL RIGHTS RESERVED BY THE ROCKEFELLER INSTITUTE PRESS IN ASSOCIATION WITH OXFORD UNIVERSITY PRESS Library of Congress Catalogue Card Number 60-13207 PRINTED IN THE UNITED STATES OF AMERICA CONTENTS CHAPTER ONE The Ethical Dilemma of Science Living mechanism 5 The present tendencies and the future compass of physiological science 7 Experiments on frogs and men 24 Scepticism and faith 39 Science, national and international, and the basis of co-operation 45 The use and misuse of science in government 57 Science in Parliament 67 The ethical dilemma of science 72 Science and witchcraft, or, the nature of a university 90 CHAPTER TWO Trailing One's Coat Enemies of knowledge 105 The University of London Council for Psychical Investigation 118 "Hypothecate" versus "Assume" 120 Pharmacy and Medicines Bill (House of Commons) 121 The social sciences 12 5 The useful guinea-pig 127 The Pure Politician 129 Mugwumps 131 The Communists' new weapon- germ warfare 132 Independence in publication 135 ~ CONTENTS CHAPTER THREE About People Bertram Hopkinson 1 39 Hartley Lupton 142 Willem Einthoven 144 The Donnan-Hill Effect (The Mystery of Life) 148 F. W. Lamb 156 Another Englishman's "Thank you" 159 Ivan P. Pavlov 160 E. D. Adrian in the Chair of Physiology at Cambridge 165 Louis Lapicque 168 E. J. Allen 171 William Hartree 173 R. H. Fowler 179 Joseph Barcroft 180 Sir Henry Dale, the Chairman of the Science Committee of the British Council 184 August Krogh 187 Otto Meyerhof 192 Hans Sloane 195 On A. -
Contributors
Contributors Rama M. Aiyawar (Self-Diffusion in Sodium Single Crystals), a native of Hyderabad, India, received his B.Sc. from Osmania University, India, and M.S. from the University of Richmond. He was recently a graduate student in the department of physiology at MCV, and is now a graduate student at M.I.T. Hermann K. F. Blaschko (Observations on Chromaffin Tissue) took an M.D . degree at Freiburg e/ Br., Germany, in 1925, and a Ph.D. at Cambridge in 1939. He worked in Germany with 0 . Meyerhof, and in England with A. V. Hill and Sir Joseph Barcroft. He went to the department of pharmacology at Oxford University in 1944, where he is now reader in biochemical pharmacology and a Fellow of Linacre College. He is a Fellow of the Royal So ciety and an honorary professor at Heidelberg University. He received a doctorate of Medicine honoris causa from the Free University of Berlin in 1966. He lectured at MCV in April, 1961. Ernest Buediog ( Cholinergic Responses of Schistosoma mansoni) was born in Frankfurt, Germany, and began his study of medicine at the University of Frankfurt, where he studied physiology under Dr. Ernst Fischer. He received his M.D. degree from the University of Paris, France, and has taught at the University of Istanbul, Turkey, New York University, Western Reserve, Oxford (on Fulbright and Guggenheim fellowships) , and Louisi ana State University. Dr. Bueding has been at the Johns Hopkins University since 1960, where he is professor of pathobiology in the School of Hygiene and Public Health and professor of pharmacology in the School of Medicine. -
Sir Joseph Barcroft C.B.E., M.A., D.Sc., Hon. M.D., Hon. F.R.C.O.G., F.R.S
Downloaded from https://www.cambridge.org/core Obituary SIR JOSEPH BARCROFT, C.B.E., M.A., D.Sc., Hon. hI.D., Hon. F.R.C.O.G., F.R.S. The Nutrition Society is mourning the loss of its Chairman, Sir Joseph Barcroft, who . IP address: died suddenly from a heart attack in Cambridge on zr March. Surely no society ever had a more devoted, energetic and conscientious Chairman-but Barcroft was more than this, for in the Chair (as out of it) he would be at the same time both wise and 170.106.33.14 witty; and he combined an inflexible integrity and high purpose with tact and with a gay, happy charm; and much learning with simplicity and humility; and he was rich in human sympathy and understanding. , on Only those who served with him as Honorary officers, or on the Council, can know 26 Sep 2021 at 05:31:40 the full extent of the generous and unselfish work he did for the Society. He had been active in its interests from the start, having been one of the signatories of the ‘ mani- festo’ which led to its foundation, and having taken the Chair at its first discussion, at the inaugural scientific meeting in Cambridge on 18 October 1941. He consented to join the Committee in 1942, became Chairman of the English Group in 1% and , subject to the Cambridge Core terms of use, available at since 1945 had been Chairman of the Society. The Council were to have nominated him as President for the Session 1947-8,under the new constitution. -
Inside Living Cancer Cells Research Advances Through Bioimaging
PN Issue 104 / Autumn 2016 Physiology News Inside living cancer cells Research advances through bioimaging Symposium Gene Editing and Gene Regulation (with CRISPR) Tuesday 15 November 2016 Hodgkin Huxley House, 30 Farringdon Lane, London EC1R 3AW, UK Organised by Patrick Harrison, University College Cork, Ireland Stephen Hart, University College London, UK www.physoc.org/crispr The programme will include talks on CRISPR, but also showing the utility of techniques such as ZFNs and Talens. As well as editing, the use of these techniques to regulate gene expression will be explored both in the context of studying normal physiology and the mechanisms of disease. The use of the techniques in engineering cells and animals will be explored, as will techniques to deliver edited reagents and edited cells in vivo. Physiology News Editor Roger Thomas We welcome feedback on our membership magazine, or letters and suggestions for (University of Cambridge) articles for publication, including book reviews, from Physiological Society Members. Editorial Board Please email [email protected] Karen Doyle (NUI Galway) Physiology News is one of the benefits of membership of The Physiological Society, along with Rachel McCormack reduced registration rates for our high-profile events, free online access to The Physiological (University of Liverpool) Society’s leading journals, The Journal of Physiology and Experimental Physiology, and travel David Miller grants to attend scientific meetings. Membership of The Physiological Society offers you (University of Glasgow) access to the largest network of physiologists in Europe. Keith Siew (University of Cambridge) Join now to support your career in physiology: Austin Elliott Visit www.physoc.org/membership or call 0207 269 5728. -
Appendix 1 Chronology of Main Events
APPENDIX 1 CHRONOLOGY OF MAIN EVENTS 384-322 B.C.E. Aristotle allegedly stated that the air on high mountains was "too thin for respiration." Cited by Robert Boyle (1660, p. 357) (Fig. 1.1) but disputed. C. 30 B.CE. Reference to the Great Headache Mountain and Little Headache Mountain in the Ch'ien Han Shu (Fig. 1.3). 354-430 St. Augustine of Hippo refers to the thinness of the air on mountains (Fig. 1.2). 399-414 Fa-hien's companion died on a mountain and "a white froth came from his mouth" (Fig. 1.5). This may be the first recorded example of high-altitude pulmonary edema. 1590 Publication by Joseph de Acosta of Historia Natural y Moral de las Indias with its account of mountain sickness (first Spanish edition) (Fig. 1.6). 1598 Anello Oliva also referred to sickness on mountains caused by the thinness of the airs. Other Spanish chroniclers such as Alonso de Ovalle made similar statements. 1604 English translation of Acosta's book The Natural/ and Moral/ Historie of the East and West Indies. 1620 Francis Bacon referred to the belief by the ancients of the rarity of the air on the summit of Mt. Olympus, and the fact that the air was not dense enough for respiration. 1628 William Harvey described the circulation of the blood in De Motu Cordis. 1638 Galileo discusses the resistance of a vacuum. 401 402 HIGH LIFE 1644 Torricelli (Fig. 1.11) invents the mercury barometer and recognizes that the mercury is supported by the weight of the atmosphere (Fig. -
Some Irish Quaker Naturalists
SOME IRISH QUAKER NATURALISTS Introduction peakers are always advised to avoid apologies; none the less I think that some explanations are required before launching on Smy subject. First it is characteristic of the generosity of the Friends Historical Society that they from time to time ask an Irish Friend to act as President. Britain or to be more accurate England is the true centre of early Quakerism and it is inevitable that historical studies have their true root here. Other branches of the Society of Friends must first look to their English origins, but they have put down adventitious roots into their own soil; and it is good when this is recognised. Amongst other Irish Friends recognised by the FHS have been Isabel Grubb, John M. Douglas and Olive Goodbody each of whom some of you will remember with appreciation. Unknown to them they taught me much of what I know, and each of them had particular scholarly abilities which I cannot copy. In fact although I have written abut The Irish Quakers, I am essentially a second handler, having spent little time on original sources. I was asked about two years ago to join in a symposium on Quakers in Irish Natural History and Medicine. Why should Quakers have had any importance in relation to a country's natural philosophy? We had realised that the Quaker community had made a disproportionate contribution to the Irish economy; and that they had in a special way served the country in time of famine and even of rebellion; but that it had a special place in the development of Ireland's science and medicine seemed unlikely and was certainly unrecognised. -
Sir Joseph Barcroft, Cambridge Placental and Fetal Research (1933-1966) and Inter-Generational Science
Int. J. Dev. Biol. 54: 257-268 (2010) DEVELOPMENTALTHE INTERNATIONAL JOURNAL OF doi: 10.1387/ijdb.082762rb BIOLOGY www.intjdevbiol.com Sir Joseph Barcroft, Cambridge placental and fetal research (1933-1966) and inter-generational Science ROBERT BOYD1 and C.A. RICHARD BOYD*,2 1Maternal and Fetal Health Research Group, University of Manchester, St Mary’s Hospital, UK and 2Brasenose College, Oxford, UK ABSTRACT The nature of Cambridge (UK) placental and fetal research in the middle third of the twentieth century is reviewed on the basis of published literature and personal recollection. Joseph Barcroft is a central figure who came to fetal research late in an extremely productive career which is briefly sketched. Contemporaneous Cambridge academics in the field included J.D. Boyd (the authors’ father), J. Hammond, F.H.A. Marshall, R.A. McCance, J. Needham, A.S. Parkes and Elsie Widdowson. The then current Cambridge academic geography is explained and features of its scientific life such as funding, institutional structure and ethos, teaching and clinical duties, domestic and gender roles, and political context, including war and empire, are briefly considered. The testing of research findings against general principles and use of quantitative thinking are identified as important features. Intergenerational connections, often within indi- vidual families, are identified as a striking feature. The long-term impact of Cambridge work of this period; locally, in current trophoblast and feto-placental genetic research, in Oxford in probably influencing G.S. Dawes’ research leadership, and internationally, especially through D.H. Barron, and through him to the Denver School, is considered. That human placental and embryological specimens collected by J.D. -
Hypoxia, Fetal & Neonatal Physiology: 100 Years on from Sir Joseph Barcroft 1D a Giussani, 2L Bennet, 1A N Sferruzzi-Perri
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Apollo Hypoxia, Fetal & Neonatal Physiology: 100 years on from Sir Joseph Barcroft 1D A Giussani, 2L Bennet, 1A N Sferruzzi-Perri, 1O R Vaughan & 1AL Fowden 1Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK 2The Department of Physiology, University of Auckland, Auckland, New Zealand Journal: Journal of Physiology Submission: Editorial Correspondence: Professor Dino A Giussani, Ph.D. Department of Physiology Development & Neuroscience Downing Street University of Cambridge Cambridge CB2 3EG UK Tel: +44 1223 333894 E-mail: [email protected] 1 1 During the history of the Earth there have been dramatic changes in its oxygen 2 (O2) availability (Graham et al. 1995). Geochemical models suggest that in the 3 mid-to-late Devonian era (ca. 380 million years ago, mya), O2 levels in the Earth’s 4 atmosphere increased from ~18 to 20%. By the late Carboniferous period (286 5 mya), the Earth’s oxygenation had risen sharply to ~35%, which palaeontologists 6 refer to as ‘the oxygen pulse’. Through the following Permian and Palaeozoic eras, 7 approximately 250 mya ago, O2 concentrations fell to ~11%. Thereafter, in the last 8 200 million years, O2 levels steadily increased again, settling at the present day 9 level of ~21%. 10 11 These fluctuations in O2 availability have shaped the evolution of animal life on 12 Earth and are one of the earliest challenges in physiological history. When O2 13 availability increased animals harnessed this new fuel and grew larger irrespective 14 of their phyla. -
Dale's Schooldays the Early Education of a Nobel Laureate: Henry
Downloaded from rsnr.royalsocietypublishing.org on June 2, 2011 The early education of a Nobel laureate: Henry Dale's schooldays E. M. Tansey Notes Rec. R. Soc. published online June 1, 2011 doi: 10.1098/rsnr.2011.0018 P<P Published online June 1, 2011 in advance of the print journal. This article is free to access Subject collections Articles on similar topics can be found in the following collections biographical history (32 articles) history of medical sciences (10 articles) Receive free email alerts when new articles cite this article - sign up Email alerting service in the box at the top right-hand corner of the article or click here Advance online articles have been peer reviewed and accepted for publication but have not yet appeared in the paper journal (edited, typeset versions may be posted when available prior to final publication). Advance online articles are citable and establish publication priority; they are indexed by PubMed from initial publication. Citations to Advance online articles must include the digital object identifier (DOIs) and date of initial publication. To subscribe to Notes Rec. R. Soc. go to: http://rsnr.royalsocietypublishing.org/subscriptions This journal is © 2011 The Royal Society Downloaded from rsnr.royalsocietypublishing.org on June 2, 2011 Notes Rec. R. Soc. doi:10.1098/rsnr.2011.0018 Published online THE EARLY EDUCATION OF A NOBEL LAUREATE: HENRY DALE’S SCHOOLDAYS by E. M. TANSEY* School of History, Queen Mary University of London, Mile End Road, London E1 4NS, UK This paper examines the early schooling, in London and in Cambridge, of the later Nobel laureate and President of the Royal Society, the physiologist Sir Henry Dale (1875– 1968). -
Professor AV Hill, CH, Sc.D., LL.D., FRS, 1886–1977
Royal Society Library, 1 946 Whale Island, Portsmouth, 1918 {Facing p. 545) Downloaded from https://www.cambridge.org/core. IP address: 170.106.202.126, on 24 Sep 2021 at 17:19:45, subject to the Cambridge Core terms of use, available at https://www.cambridge.org/core/terms. https://doi.org/10.1017/S0025315400041199 J. mar. biol. Ass. U.K. (1978) 58, 545-549 545 Printed in Great Britain OBITUARY PROFESSOR A. V. HILL, C.H., Sc.D., LL.D., F.R.S., 1886-1977 Soon after Lord Salisbury had succeeded Gladstone as Prime Minister, at a time when the British Empire was still growing and the newly formed Marine Biological Association of the U.K. was building a laboratory on Citadel Hill in Plymouth, Archibald Vivian Hill was born in Bristol on 26 September 1886. He died in Cambridge on 3 June 1977 and shortly before his death, he was tempted to agree with a friend that 'we are wit- nessing something like the decline and fall of the Roman Empire compressed into ten years instead of four hundred'. This was uncharacteristic pessimism for, to the end of his life, he was unfailingly cheerful and always encouraging to younger people and viewed with optimism the future of the Marine Biological Association to which he had devoted so much thought and effort. A. V. Hill showed great early ability as a mathematician, taking, from Blundell's School in Tiverton, a Major Mathematical Scholarship to Trinity College, Cambridge. There he became 3rd Wrangler in 1907 and was persuaded by W. -
Sir Bernard Katz 348
EDITORIAL ADVISORY COMMITTEE Albert J. Aguayo Bernice Grafstein Theodore Melnechuk Dale Purves Gordon M. Shepherd Larry W. Swanson (Chairperson) The History of Neuroscience in Autobiography VOLUME 1 Edited by Larry R. Squire SOCIETY FOR NEUROSCIENCE 1996 Washington, D.C. Society for Neuroscience 1121 14th Street, NW., Suite 1010 Washington, D.C. 20005 © 1996 by the Society for Neuroscience. All rights reserved. Printed in the United States of America. Library of Congress Catalog Card Number 96-70950 ISBN 0-916110-51-6 Contents Denise Albe-Fessard 2 Julius Axelrod 50 Peter O. Bishop 80 Theodore H. Bullock 110 Irving T. Diamond 158 Robert Galambos 178 Viktor Hamburger 222 Sir Alan L. Hodgkin 252 David H. Hubel 294 Herbert H. Jasper 318 Sir Bernard Katz 348 Seymour S. Kety 382 Benjamin Libet 414 Louis Sokoloff 454 James M. Sprague 498 Curt von Euler 528 John Z. Young 554 Sir Bernard Katz BORN: Leipzig, Germany March 26, 1911 EDUCATION: University of Leipzig, M.D., 1934 University College of London, Ph.D. (Physiology, with A.V. Hill, 1939) APPOINTMENTS: Sydney Hospital, Australia (1939) University College of London (1946) Professor of Biophysics Emeritus, University College of London (1978) HONORS AND AWARDS: Fellow, Royal Society of London (1952) Copley Medal, Royal Society (1967) Fellow, Royal Society of Physicians (1968) Foreign Associate, American Academy of Arts and Sciences (1961) Nobel Prize for Physiology or Medicine (1970) Foreign Associate, National Academy of Sciences USA (1976) Ralph W. Gerard Prize, Society for Neuroscience (1990) Sir Bernard Katz carried out fundamental studies of the neuromuscular junction. He established the quantal nature of neurotransmitter release, and described the mechanism of synaptic transmission.