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American Society for Biochemistry and Molecular Biology Vol. 12 No. 7 August 2013 American Society for Biochemistry and Molecular Biology contents AUGUST 2013 On the cover: In this issue, we offer news, news advice and perspectives about various aspects of work 3 President’s Message and school. 27 Imagining a sustainable biomedical enterprise 5 News from the Hill Turning controversy into action 6 Member Update 8 Annual award winners 9 Retrospectives 9 François Jacob (1920 – 2013) 11 Adolphus P. Toliver (1931 – 2013) This month’s contribution to our essay series is by Harvey “Jim” Armbrecht, who writes about his wife’s diagnosis of Lewy features body disease and about the SAMP8 mouse, a model for early memory loss. 14 18 Virginia Lee: notes on a career 24 Venom-based therapies departments INSIDE THE BROWN BAG 44 Outreach ISSUE Rap Genius 28 Going M.D./Ph.D. vs. going 100% Ph.D. 46 Journal News 29 The evolution of biomedical science and you 46 JBC: A deeper look into cholesterol synthesis 30 Plenty of options for students with all degrees of interest in research and medicine 47 JBC: Potent antifreeze protein’s structure determined 31 A blog, a CV and a domain name 47 JBC: James E. Darnell’s “Reections” 32 Crafting an online presence 35 How to nd the right lab rotation 49 JBC: Recent ndings on presenilins and signal peptide peptidase 35 How to broach the funding issue with prospective PIs 49 JLR: Thematic series on fat-soluble vitamins 37 Choosing the right journal for your work 50 MCP: Protein quantication: by mass 39 The brains behind Coursera’s spectrometry or Western blotting? neuroscience offering 42 AARP’s annual ranking of workplaces for 51 Career Insights employees over 50 Lessons learned: notes on becoming an educator outside of academia 53 Mentoring Taking a holistic view 56 Lipid News N Fer! Coenzyme A: when small is mighty POINT / COUNTERPOINT Eleftherios P. Diamandis and Peter J. Kennelly weigh in on whether publishers should compensate reviewers. 16 August 2013 ASBMB Today 1 onlineonline president’sag A monthly publication of cvcv The American Society for Biochemistry and Molecular Biology www.asbmb.org/asbmbtoday Imagining a sustainable Officers Jeremy M. Berg President biomedical enterprise Steven McKnight President-Elect Karen Allen Secretary NIH to begin mass BY JEREMY BERG Toni Antalis Treasurer Council Members retirement of research Squire J. Booker Brenda Schulman David Sabatini Melissa Starovasnik chimpanzees he opportunities for research in biochemistry than better so that the status quo is not sustainable. Wesley I. Sundquist Gregory Gatto Jr. and molecular biology and related areas to have It is easy to imagine a sustainable future in broad Natalie Ahn Anjana Rao T Daniel Leahy The National Institutes of Health will begin retiring impact both on basic knowledge and on human health, strokes. Note that building a sustainable enterprise is PHOTO CREDIT: NATIONAL INSTITUTES OF HEALTH Ex-Officio Members many of the nearly 1,000 captive chimpanzees Pumpkin is a 24-year-old chimpanzee energy and other essential areas are tremendous, not just a matter of gaining increased financial sup- Geeta Narlikar Enrique de la Cruz to the Federal Sanctuary System, leaving roughly living at the Alamogordo Primate almost unprecedented. Yet at the same time, the sys- port. The fact that federal support for research has not Co-chairs, 2014 Annual Meeting Program Committee Facility in New Mexico. Peter J. Kennelly, Chair, Education and Professional 50 for future experimentation needs. The move tem, broadly defined, for conducting such research is even kept pace with inflation for a decade has exposed Development Committee comes as the NIH begins to implement the recommendations of an Institute of struggling with many challenges. In academia, principal structural defects in the system, but these defects Daniel Raben, Chair, Meetings Committee Fred Maxfield, Chair, Mentorship Committee Medicine report regarding the necessity of chimpanzees for biomedical research. Read investigators are spending much of their time writing existed independent of the level of support. With that Terri Kinzy, Chair, Membership Committee more about this from ASBMB’s science policy fellow, Chris Pickett, and reviewing grant proposals rather than conduct- said, we must make the strongest possible case for Takita Felder Sumter, Chair, Minority Affairs Committee at asbmb.org/asbmbtoday. ing research. Many faculty members are dependent continued and increased support for research because Thomas Baldwin, Chair, Outreach Committee Bob Matthews, Chair, Public Affairs on the success of such proposals not just to facilitate of the great dividends these investments will pay to Advisory Committee their research but also for their continued employment. society in terms of knowledge; improvements in health, Jeffrey Benovic, Chair, Publications Committee At the same time, universities and other institutions energy and other fields; and both short- and long-term Martha J. Fedor, Editor-in-chief, JBC The first Source Files Herbert Tabor, Co-editor, JBC Unearthing hidden post features John J. are increasingly dependent on the success of these pro- economic development. Our focus on sustainability is A. L. Burlingame Abel of Johns Hopkins Editor, MCP University, who founded posals for their financial viability. Many talented young most certainly not a matter of conceding that subin- Edward A. Dennis gems in the ASBMB the Journal of Biological people who have embarked on careers in biomedical flationary budget increases are inevitable or are good Joseph L. Witztum Chemistry in 1905 with fields find themselves in long periods of training that policy. Indeed, a clear vision for a sustainable enterprise Co-editors, JLR archives Christian Herter. The next year, he founded ASBMB Today Editorial Advisory Board may be too narrow to prepare them for the range of is likely to be most important as a driver for and in the Discovery: It’s what you’re about. But ASBMB (then the Ameri- Charlie Brenner (Chair) can Society of Biological career opportunities that may be of interest to them. presence of increased investments. Carol Shoulders Shiladitya Sengupta ferreting out the prized, charming Chemists). Abel served Interactions between academia and the pharmaceutical In a sustainable enterprise, researchers would Yolanda Sanchez Floyd “Ski” Chilton as the society’s second Cristy Gelling Peter J. Kennelly and peculiar pieces of your field’s president in 1908. and biotechnology companies are of increasing interest still compete for funding through peer-review-based Michael Bradley Rajini Rao history isn’t exactly something you to both groups, but the frameworks for these interac- processes, because this has proved to be an effective ASBMB Today have a ton of time to do, which is why we decided to do it for you in a new website tions are often cumbersome and challenging to set up means for allocating resources to the most impor- Angela Hopp Editor called Source Files. There, you’ll find figures and photos from our archives that struck and may not optimally support the goals of the partici- tant ideas. However, in a sustainable environment, [email protected] Rajendrani Mukhopadhyay our fancy. Sometimes serious, sometimes not, these brief posts are meant to make pants. The federal government is both a major financial the process would be more efficient so that less time Sr. Science Writer more discoverable the stories our journals and society have told over the decades. Visit supporter of biomedical and biological research and was spent writing and reviewing proposals, freeing [email protected] the source of regulations that affect Marnay Harris Designer Source Files at asbmbsourcefiles.tumblr.com. Send suggestions to [email protected] [email protected]. academia and industry. The finan- Andrew Harmon Science and Technology cial support has not kept up with Publishing Manager, [email protected] inflation over the past decade and Sustainability can be achieved Nancy J. Rodnan Director of Publications [email protected] has been eroded substantially by only by encouraging the major Barbara Gordon Executive Director the enactment of sequestration in [email protected] Spreading the word about health disparities For information on advertising, the present fiscal year. The regula- stakeholders to engage in serious contact Fox Associates Inc. at 800-440-0231 The Prairie View A&M University College of Nursing in the Texas Medical Center in tions, while developed with the best or [email protected]. Houston hosted the 11th annual Disparities in Health in America Summer Workshop of intentions, may not strike the and thoughtful self-examination in mid-June. The six-day continuing-education program, offered to healthcare optimal balance between preven- and then bringing them together professionals, social workers, students, community members and civic leaders, this tion of undesirable events and time year had the theme “Working Towards Social Justice.” Lovell A. Jones, who won the and financial burdens that decrease to develop policies and programs www.asbmb.org/asbmbtoday American Society for Biochemistry and Molecular Biology’s Ruth Kirschstein Diversity in productivity. Finally, an analysis of that will set the system in the right Science Award in 2012, served as the program chairman. See a slideshow of photos trends indicates that many of these from the event at asbmb.org/asbmbtoday. problems are getting worse rather direction. 2 ASBMB Today August 2013 August 2013 ASBMB Today 3 president’sag continued from the hill up time actually to do the research. Young scientists The purpose of this white paper is to serve as a would come out of their training at an earlier stage and conversation starter with a broad group of stakehold- ws well prepared for the exciting range of career paths in ers. The first important group of stakeholders is the biomedical research. Academia, industry and govern- membership of the ASBMB. We are reaching out to ment would interact almost seamlessly to harness basic other scientific societies, groups and key individuals to Turning controversy into action research advances into applications and products that get their input as well.
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