Risk Factors, Seroprevalence and Infectivity of Hepatitis B Virus
ISSN: 2474-3658 Ogbonna et al. J Infect Dis Epidemiol 2021, 7:186 DOI: 10.23937/2474-3658/1510186 Volume 7 | Issue 1 Journal of Open Access Infectious Diseases and Epidemiology Research ArticlE Risk Factors, Seroprevalence and Infectivity of Hepatitis B Virus amongst Children Resident in Orphanages in a Developing Country Chioma Paulina Ogbonna, MBBS, FMCPaed1, Christian Chukwukere Ogoke, MBBS, FWACP2* , Anthony Nnaemeka Ikefuna, MBBS, FMCPaed, FRCP3,4, Tochukwu 1 Check for Chukwukadibia Ezeofor, MBBS, FMCpaed, FRCP , Emeka Charles Nwolisa, MBBS, updates FWACP, FRCP5, Franklin Chime Emerenini, MBBch, FMCpaed1, and Christopher Bismarck Eke MBBS, FWACP4,6 1Consultant Paediatrician, Department of Paediatrics, Federal Medical Centre, Owerri, Nigeria 2Paediatric Neurology Unit, Department of Paediatrics, King Fahad Central Hospital, Abu Arish 82666, Kingdom of Saudi Arabia 3Professor of Paediatrics, Faculty of Medical Sciences, Department of Paediatrics, University of Nigeria, Nigeria 4Consultant Paediatrician, University of Nigeria Teaching Hospital, Nigeria 5Chief Consultant Paediatrician, Federal Medical Centre, Owerri, Nigeria 6Senior Lecturer, Department of Paediatrics, University of Nigeria, Nigeria *Corresponding authors: Dr. Christian Chukwukere Ogoke, Paediatric Neurology Unit, Department of Paediatrics, King Fahad Central Hospital, Abu Arish 82666, Kingdom of Saudi Arabia Abstract Results: Seroprevalence of HBsAg in children in orphanag- es was 20.0% versus 10.7% in the controls (P = 0.031). In- Background: Hepatitis B infection (HBV) remains a signifi- fectivity of HBV was higher in subjects (42.9%) than controls cant clinical and public health problem and is hyperendemic (20.0%) (P = 0.245). Sharing of towel (P = 0.014) sharing of in Nigeria. In highly endemic regions, infections spread from barbing devices (P = 0.001) and circumcision (P = 0.005) mother to child, or by horizontal transmission, with the bur- were the significant risk factors for Hepatitis B virus infec- den of infection being highest in under-fives.
[Show full text]