611130 Outgoing Amendment No. 52 to Curium US LLC to License No

NRCFORM374 PAGE 1 OF 5 PAGES U.S. NUCLEAR REGULATORYCOMMISSION Amendment No. 52 MATERIALS LICENSE

Pursuant to the Atomic Energy Act of 1954, as amended, the Energy Reorganization Act of 1974 (Public Law 93-438), and Title 10, Code of Federal Regulations, Chapter I, Parts 30, 31, 32, 33, 34, 35, 36, 37, 39, 40, 70 and 71, and in reliance on statements and representations heretofore made by the licensee, a license is hereby issued authorizing the licensee to receive, acquire, possess, and transfer byproduct, source, and special nuclear material designated below; to use such material for the purpose(s) and at the place(s) designated below; to deliver or transfer such material to persons authorized to receive it in accordance with the regulations of the applicable Part(s). This license shall be deemed to contain the conditions specified in Section 183 of the Atomic Energy Act of 1954, as amended, and is subject to all applicable rules, regulations, and orders of the Nuclear Regulatory Commission now or hereafter in effect and to any conditions specified below.

Licensee In accordance with letter dated 4. Expiration Date: July 31, 2022 Janua~22...2.0J», 1. Curium US LLC ~~t\ Kt:G t------..iii-,..iii-,--1 5. Docket No.: 030-10801 2. 2703 Wagner Place 3. license No.: 24-04206-05f\A[() Reference No.: Maryland Heights, MO 63043 is amended in Its entirety to re~ as follows: i!" 1 ~i\il'W,

·~ 6. Byproduct, source, 7. Chemical ahttor physical form 8. Maximum amount that lice~e 9. Authorized use and/or special nuclear may possess at any one tfmel material this license

A. lodine-131 A. Sodium iol& capsules (NDA possession authoriz,~ A. The licensee is authorized to distribute 16-517) -,\~1~:, the byproduct material described in Items 6 and 7 of this license to 1) pursuant to Section 32.72 of 10 CFR Part 32, persons licensed pursuant to Sections 35.100, 35.200 and 35.300 of 10 CFR Part 35, or under equivalent licenses of Agreement States, or 2) commercial nuclear pharmacies. "'s.::_, B. lodine-131 B. Sodium iodide liquid (NDA B. No possession authorized B. Same as Item 9.A. 16-515) NRC FORM 374A U.S. NUCLEAR REGULATORYCOMMISSION PAGE 2 OF 5 PAGES License Number Docket or Reference Number 24-04206-0SMD 030-10801 MATERIALS LICENSE SUPPLEMENTARY SHEET Amendment No. 52

6. Byproduct, source, 7. Chemical and/or physical form 8. Maximum amount that licensee 9. Authorized use and/or special nuclear may possess at any one time material e;iis license C. Molybdenum-99/ C. Generators (Mallinckro~~ ~ No I ~~rator to C. The licensee is authorized to distribute Technetium-99m Ultra-Technekow DriTo uting exceed 1 . is at the the byproduct material described in time of shipme ·o Items 6 and 7 of this license to 1) pursuant to Section 32. 72 of 10 CFR Part 32, persons licensed pursuant to Section 35.200 of 10 CFR Part 35, or under equivalent licenses of Agreement States, or 2) commercial nuclear pharmacies. 'ill'' . D. lndium-111 D. Indium ch~e liquid (NOA possession authoriz~ D. The licensee is authorized to distribute 20-314 arfrl'JDA 19-841) -~ the byproduct material described in tn Items 6 and 7 of this license to 1) pursuant to Section 32.72 of 10 CFR Part 32, persons licensed pursuant to Sections 35.100 a11d35.200 of 10 CFR Part 35, or under equivalent licenses of Agreement States, or 2) commercial >'~1;/ , nuclear pharmacies. k:r-"',,ri11h~ cjt~ E. Thallium-201 E. Thallous chloride liqu~{No~ E. No po1session authorized E. Same as Item 9.0. 18-150) F. Gallium-67 F. Gallium citrate liquid (NDA F. . No possession authorized F. Same as Item 9.0. 18-058) G. lodine-123 G. Sodium iodide liquid (NDA G. No possession authorized G. Same as Item 9.0. 17-909 and NDA 17-910) H. Xenon-133 H. Xenon gas (NDA 18-327) H. No possession authorized H. Same as Item 9.0.

I. Thorium-227 I. Thorium liquid conjugate I. No possession authorized I. For distribution of radioactive drugs and radiochemicals for medical use in accordance with 10 CFR 32.72. NRC FORM37AA U.S. NUCLEAR REGULATORYCOMMISSION PAGE 3 OF 5 PAGES License Number Docket or Reference Number 24-04206-0SMD 030-10801 MATERIALSLICENSE SUPPLEMENTARYSHEET Amendment No. 52

CONDITIONS 10. Each product distributed under this license shall not CSDt~.~ oR,~y gate (labeled size at calibration), more than the quantity of byproduct material listed in the table contained in f.~111 i to the licensM'i)~~ated July 10, 2018 (ML 18192A827).

11. The licensee may distribute material from t~-~nsee's facilities located at 2703 Wa~flace, Maryland Heights, Missouri, 63043.

12. This license does not authorize possess r use of llcensed material.

13. The Radiation Safety Officer (RSO) for~ license is Mlnuel Diaz.

14. The licensee shatl notify the U.S. Nucl81f:jRegulitory Co~ls thirty(30) days of. termination of a "Notice of Claimed lnvestigational Exemption for a New Drua,!.IND)" fgfftcensed escribed In Items d 7.

15. Any proposed change to shielding that ease the radiation te\.'e1s of the packagi aUbe submitted to the NRC for review. Any proposed change to labeling that will cause nge to radioactive m111rkingsor lab ctivity, other than position and increasing the size of symbols and wording, shall be submitted to NRC FORM 374A U.S. NUCLEAR REGULATORYCOMMISSION PAGE 4 OF 5 PAGES License Number Docket or Reference Number 24-04206-0SMO 030-10801 MATERIALSLICENSE SUPPLEMENTARYSHEET Amendment No. 52

16. Except as specifically provided otherwise in this license, the licensee shall manufacture, package, label and distribute licensed material described in Items 6 and 7 of this license and conduct its program in accordance with the statements, representations, and procedures contained in the documents, including any enclosuresJisltc:JIJ5\,lofil Fhicigepse condition applies only to those procedures that are required to be submitted in accordance with the reg~l~~'rhe u.s':'~cW~Jiulatory Commission's regulations shall govern unless the statements, representations, and procedures i\-~ensee's application and cor'rf~ndence are more restrictive than the regulations. t rTuv' A. Letter dated April 28, 2011 (ML 11121/;2~ B. Letter dated February 7, 2012 (ML1 0356)

C. Letter dated August 30, 2012 (ML 1 ' 9A442) . •. • 0 D. Application dated March 5, 2013 (r~beling revisJi::,ns) (ML1308.7A379) E. Letter dated July 11, 2013 (includirj)ttache·d··· s.·ECFotmtftlr .wne28,2013) (M~196A098) F. Letter dated July 18, 2013 (ML 13~380) . G. Application dated July 24, 2014 (ML 1 209A090, H. Application dated August 22, 2014 (r . 0 DeleptionotJijl.lJf(ML14239A329~ I. Letter dated October 27, 2014 (re: Fig 1 and 2 organitatton charts) (ML 1432~8) J. Letter dated March 16, 2015 (ML 15077 · , Q K. Letter dated September 21, 2015 (ML 1526 AfS)9) - L. Letter dated February 22, 2016 (ML 16076A387) NRC FORM 374A U.S. NUCLEAR REGULATORYCOMMISSION PAGE 5 OF 5 PAGES License Number Docket or Reference Number 24-04206-05MD 030-10801 MATERIALS LICENSE SUPPLEMENTARY SHEET Amendment No. 52

M. Letter dated January 27, 2017 (ML 17030A415) N. Letter dated June 4, 2018 (re: d/b/a Curium) (ML 16156A467)D. 0. Letter dated July 10, 2018 (re: Attachments D, G ~~lift) (Ml.6~]) 1 P. Letter dated January 22, 2019 (ML 19023A4tj,'v ' '''"~il a. Letter dated April 2, 2019 (ML 190938579~) ''6 ~,'~ '*,

~t)RTHE U. S. NUCLEAR REGULATO~Y COMMISSION

Date: APR1 6 2019 By: ------ff------B ry an A. Parker Region HI