Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Valorphin TFA(144313-54-2(free bas)) Catalog Number : T7666 CAS Number : T7666 Molecular Formula : C46H62F3N9O13 Molecular Weight : 1006.03

Description: Valorphin TFA is a semisynthetic derivative of dihydrovaltrate with activity

Storage: 2 years -80°C in solvent; 3 years -20°C powder; In vitro Activity In vitro binding studies using brain homogenates from rat and guinea-pig indicate a preference for the mu-receptor site. Bath application to cultured cerebellar Purkinje cells inhibited the spontaneous firing, similar to the effect seen with . Analgesic activity has been demonstrated in the hot plate and the tail flick test in the mouse and the Randall-Selitto test in the rat. In the rhesus monkey valorphin was self-administered, but challenge induced only mild withdrawal signs. Valorphin is a novel chemical entity, structurally not related to known , which interacts preferentially with mu- receptors[1].

Reference 1. Maurer R , R Mer D , H.H. Büscher, et al. Valorphin: A novel chemical structure with opioid activity[J]. , 1985, 5(4-6):387-390. 2. Smith W D . A COMPARISON IN MICE OF NALOXONE AND AS ANTAGONISTS TO NEUROLEPTANALGESIC DRUGS[J]. BJA: British Journal of Anaesthesia(11):11.

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