Análisis DAVID_325genes_FDR 0.025 GRUPOS DE GO REDUNDANTES METABOLISMO CELULAR Enrichment Score (ES): 2,02

Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini

TAF1B, USPL1, ELF2, DAK, ARNT2, PAX3, PTTG1, OTUB2, SART1, FAH, CAMKK2, FANCL, PTGIS, B3GALNT1, INSIG1, RABGEF1, USP11, MRPL39, COL11A1, ATP5J, SNAPC1, SOX12, ENC1, GTF2H3, MGAT1, TAF10, ATP6V1A, EIF4G3, GLUL, HOXD8, DHX29, RPS17, RPS4Y2, MNT, RPS13, ADAM19, PAM, DERL2, FUT8, GLIS2, MAPKAPK5, MAPKAPK3, PML, ADH7, UBA5, MEIS1, MTMR2, AHRR, VRK2, METTL3, PTPLB, PTPLA, EIF3F, SNF8, THG1L, MLXIP, SUPT4H1, LHX8, DNAJA4, FOXD1, DNAJA3, TEC, UPF1, TGFBR2, AMACR, SAP18, MTHFSD, NID1, UBE2L3, EIF2B1, CISH, HOXB3, MNAT1, NOTCH1, HOXB2, ATP2A2, 9130019O22RIK, GO:004423 cellular metabolic process 86 34,68 0,003 GRIA1, TRPS1, SETD8, PARP3, EAF2, AHSA1, PAICS, UBE2E2, MYLK 1,27 0,841

TAF1B, USPL1, ELF2, ARNT2, PAX3, PTTG1, OTUB2, SART1, CAMKK2, FANCL, B3GALNT1, RABGEF1, USP11, MRPL39, COL11A1, SNAPC1, SOX12, ENC1, GTF2H3, MGAT1, TAF10, EIF4G3, HOXD8, DHX29, RPS17, RPS4Y2, MNT, RPS13, ADAM19, DERL2, FUT8, MAPKAPK5, GLIS2, MAPKAPK3, PML, UBA5, MEIS1, AHRR, VRK2, METTL3, EIF3F, SNF8, THG1L, MLXIP, SUPT4H1, LHX8, DNAJA4, FOXD1, DNAJA3, TEC, UPF1, TGFBR2, SAP18, NID1, UBE2L3, EIF2B1, CISH, HOXB3, MNAT1, NOTCH1, HOXB2, 9130019O22RIK, GRIA1, GO:0044260 cellular macromolecule metabolic process 70 28,23 0,003 TRPS1, PARP3, SETD8, EAF2, AHSA1, UBE2E2, MYLK 1,33 0,759

TAF1B, USPL1, ELF2, ARNT2, PAX3, PTTG1, OTUB2, SART1, CAMKK2, FANCL, B3GALNT1, RABGEF1, USP11, MRPL39, COL11A1, OXR1, SNAPC1, SOX12, ENC1, GTF2H3, MGAT1, TAF10, EIF4G3, HOXD8, DHX29, RPS17, RPS4Y2, MNT, RPS13, ADAM19, CTSF, DERL2, FUT8, GLIS2, MAPKAPK5, MAPKAPK3, PML, UBA5, MEIS1, AHRR, ECE1, VRK2, METTL3, EIF3F, SNF8, THG1L, MLXIP, SUPT4H1, LHX8, DNAJA4, FOXD1, DNAJA3, TEC, UPF1, TGFBR2, SAP18, NID1, UBE2L3, EIF2B1, CISH, HOXB3, QPCT, MNAT1, CD55, NOTCH1, GO:0043170 macromolecule metabolic process 75 30,24 0,008 HOXB2, 9130019O22RIK, GRIA1, TRPS1, PARP3, SETD8, EAF2, AHSA1, UBE2E2, MYLK 1,27 0,664

TAF1B, USPL1, ELF2, DAK, ARNT2, PAX3, PTTG1, OTUB2, SART1, CAMKK2, FAH, FANCL, PTGIS, B3GALNT1, INSIG1, RABGEF1, USP11, MRPL39, COL11A1, OXR1, ATP5J, SNAPC1, SOX12, ENC1, GTF2H3, MGAT1, TAF10, ATP6V1A, CD38, EIF4G3, GLUL, HOXD8, DHX29, RPS17, RPS4Y2, MNT, RPS13, ADAM19, STBD1, CTSF, PAM, DERL2, FUT8, GLIS2, MAPKAPK5, MAPKAPK3, PML, ADH7, UBA5, MEIS1, MTMR2, AHRR, ECE1, VRK2, METTL3, PTPLB, PTPLA, EIF3F, SNF8, THG1L, MLXIP, SUPT4H1, LHX8, DNAJA4, FOXD1, DNAJA3, TEC, UPF1, TGFBR2, AMACR, SAP18, MTHFSD, NID1, UBE2L3, EIF2B1, CISH, QPCT, HOXB3, MNAT1, CD55, NOTCH1, HOXB2, ATP2A2, 9130019O22RIK, GRIA1, TRPS1, HDHD2, SETD8, GO:0008152 metabolic process 94 37,90 0,029 PARP3, EAF2, AHSA1, PAICS, UBE2E2, MYLK 1,16 0,721 TAF1B, USPL1, ELF2, DAK, ARNT2, PAX3, PTTG1, OTUB2, SART1, FAH, CAMKK2, FANCL, PTGIS, B3GALNT1, INSIG1, RABGEF1, USP11, MRPL39, ATP5J, SNAPC1, SOX12, ENC1, GTF2H3, MGAT1, TAF10, ATP6V1A, EIF4G3, GLUL, HOXD8, DHX29, RPS17, RPS4Y2, MNT, RPS13, ADAM19, STBD1, CTSF, DERL2, FUT8, GLIS2, MAPKAPK5, MAPKAPK3, PML, ADH7, UBA5, MEIS1, AHRR, ECE1, VRK2, METTL3, EIF3F, SNF8, THG1L, MLXIP, SUPT4H1, LHX8, DNAJA4, FOXD1, DNAJA3, TEC, UPF1, TGFBR2, AMACR, SAP18, NID1, UBE2L3, EIF2B1, CISH, HOXB3, QPCT, MNAT1, CD55, NOTCH1, HOXB2, 9130019O22RIK, ATP2A2, TRPS1, GO:0044238 primary metabolic process 84 33,87 0,037 SETD8, PARP3, EAF2, AHSA1, PAICS, UBE2E2, MYLK 1,17 0,750

DESARROLLO Y MORFOGÉNESIS ES: 1,73 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0048705 skeletal system morphogenesis 7 2,82 0,004 HOXB3, HOXD8, GSC, HOXB2, TGFBR2, INSIG1, COL11A1 4,67 0,702 GO:0048704 embryonic skeletal system morphogenesis 5 2,02 0,006 HOXB3, GSC, HOXB2, TGFBR2, COL11A1 6,77 0,791 GO:0048706 embryonic skeletal system development 5 2,02 0,015 HOXB3, GSC, HOXB2, TGFBR2, COL11A1 5,22 0,723 GO:0048568 embryonic organ development 8 3,23 0,021 HOXB3, GSC, HOXB2, GRB2, TGFBR2, INSIG1, SH2B3, COL11A1 2,88 0,758 GO:0048598 embryonic morphogenesis 10 4,03 0,023 HOXB3, NOTCH1, GSC, HOXB2, LAMA5, GRB2, TGFBR2, INSIG1, PAX3, COL11A1 2,42 0,747 GO:0048562 embryonic organ morphogenesis 6 2,42 0,038 HOXB3, GSC, HOXB2, TGFBR2, INSIG1, COL11A1 3,23 0,751 GO:0001501 skeletal system development 7 2,82 0,110 HOXB3, HOXD8, GSC, HOXB2, TGFBR2, INSIG1, COL11A1 2,13 0,866

DESARROLLO EMBRIONARIO ES: 1,72 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GSC, GRB2, TGFBR2, ARNT2, PAX3, MFN2, HOXB3, TAF10, NOTCH1, ECE1, HOXB2, GO:0009790 embryonic development 16 6,45 0,010 LAMA5, INSIG1, SH2B3, COL11A1, DNAJA3 2,07 0,657 GO:0048598 embryonic morphogenesis 10 4,03 0,023 HOXB3, NOTCH1, GSC, HOXB2, LAMA5, GRB2, TGFBR2, INSIG1, PAX3, COL11A1 2,42 0,747

GO:0043009 chordate embryonic development 11 4,44 0,023 MFN2, HOXB3, NOTCH1, ECE1, GSC, HOXB2, GRB2, ARNT2, TGFBR2, PAX3, COL11A1 2,27 0,725

GO:0009792 embryonic development ending in birth or egg hatching11 4,44 0,025 MFN2, HOXB3, NOTCH1, ECE1, GSC, HOXB2, GRB2, ARNT2, TGFBR2, PAX3, COL11A1 2,24 0,716

ACTIVACIÓN DE LA RESPUESTA INMUNE ES: 1,3 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0051251 positive regulation of lymphocyte activation 5 2,02 0,023 CD38, CDKN1A, TGFBR2, IL4RA, DNAJA3 4,61 0,735 GO:0002696 positive regulation of leukocyte activation 5 2,02 0,027 CD38, CDKN1A, TGFBR2, IL4RA, DNAJA3 4,38 0,735 GO:0050867 positive regulation of cell activation 5 2,02 0,029 CD38, CDKN1A, TGFBR2, IL4RA, DNAJA3 4,29 0,732 GO:0002684 positive regulation of immune system process 7 2,82 0,031 CD38, CDKN1A, CD55, CADM1, TGFBR2, IL4RA, DNAJA3 2,95 0,727 GO:0002682 regulation of immune system process 8 3,23 0,078 CD38, CDKN1A, CD55, CADM1, CD59B, TGFBR2, IL4RA, DNAJA3 2,15 0,837 GO:0051249 regulation of lymphocyte activation 5 2,02 0,084 CD38, CDKN1A, TGFBR2, IL4RA, DNAJA3 3,01 0,851 GO:0002694 regulation of leukocyte activation 5 2,02 0,101 CD38, CDKN1A, TGFBR2, IL4RA, DNAJA3 2,81 0,869 GO:0050865 regulation of cell activation 5 2,02 0,103 CD38, CDKN1A, TGFBR2, IL4RA, DNAJA3 2,78 0,872

TRANCRIPCIÓN Y EXPRESIÓN GÉNICA ES: 1,27 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini TAF1B, ELF2, ARNT2, PAX3, PTGIS, B3GALNT1, MRPL39, ATP5J, SNAPC1, SOX12, GTF2H3, MGAT1, ATP6V1A, TAF10, GLUL, EIF4G3, HOXD8, DHX29, RPS17, RPS4Y2, MNT, RPS13, FUT8, GLIS2, PML, MEIS1, AHRR, SNF8, EIF3F, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, AMACR, MTHFSD, SAP18, EIF2B1, HOXB3, MNAT1, NOTCH1, HOXB2, GO:0044249 cellular biosynthetic process 49 19,76 0,006 9130019O22RIK, ATP2A2, TRPS1, SETD8, EAF2, PAICS 1,43 0,734

TAF1B, ELF2, ARNT2, PAX3, PTGIS, B3GALNT1, INSIG1, MRPL39, ATP5J, SNAPC1, SOX12, GTF2H3, MGAT1, ATP6V1A, TAF10, GLUL, EIF4G3, HOXD8, DHX29, RPS17, RPS4Y2, MNT, RPS13, FUT8, GLIS2, PML, MEIS1, AHRR, SNF8, EIF3F, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, AMACR, MTHFSD, SAP18, EIF2B1, HOXB3, MNAT1, NOTCH1, HOXB2, GO:0009058 biosynthetic process 50 20,16 0,007 9130019O22RIK, ATP2A2, TRPS1, SETD8, EAF2, PAICS 1,41 0,722

TAF1B, ELF2, FUT8, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, B3GALNT1, SNF8, EIF3F, MLXIP, SUPT4H1, MRPL39, LHX8, FOXD1, DNAJA3, UPF1, SNAPC1, SOX12, SAP18, GTF2H3, EIF2B1, HOXB3, MGAT1, TAF10, MNAT1, EIF4G3, NOTCH1, HOXD8, HOXB2, GO:0034645 cellular macromolecule biosynthetic process 41 16,53 0,008 DHX29, 9130019O22RIK, RPS17, TRPS1, RPS4Y2, MNT, RPS13, SETD8, EAF2 1,48 0,701

TAF1B, ELF2, FUT8, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, B3GALNT1, SNF8, EIF3F, MLXIP, SUPT4H1, MRPL39, LHX8, FOXD1, DNAJA3, UPF1, SNAPC1, SOX12, SAP18, GTF2H3, EIF2B1, HOXB3, MGAT1, TAF10, MNAT1, EIF4G3, NOTCH1, HOXD8, HOXB2, GO:0009059 macromolecule biosynthetic process 41 16,53 0,008 DHX29, 9130019O22RIK, RPS17, TRPS1, RPS4Y2, MNT, RPS13, SETD8, EAF2 1,48 0,640 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, TIMP2, MEIS1, AHRR, SNF8, CREG1, INSIG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, TGFBR2, SAP18, GTF2H3, NPR3, UBE2L3, SFMBT1, CISH, INHBB, HOXB3, SH3BP5, TAF10, MNAT1, EIF4G3, NOTCH1, CDKN1A, HOXD8, HOXB2, 9130019O22RIK, CD59B, TRPS1, MNT, SETD8, EAF2, GO:0019222 regulation of metabolic process 46 18,55 0,021 PPP1R15B, UBE2E2 1,36 0,806

TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, TIMP2, MEIS1, AHRR, SNF8, CREG1, INSIG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, TGFBR2, SAP18, GTF2H3, NPR3, SFMBT1, CISH, INHBB, HOXB3, SH3BP5, TAF10, MNAT1, EIF4G3, NOTCH1, GO:0031323 regulation of cellular metabolic process 44 17,74 0,021 CDKN1A, HOXD8, HOXB2, 9130019O22RIK, CD59B, TRPS1, MNT, SETD8, EAF2, PPP1R15B 1,37 0,788

TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, MEIS1, SART1, AHRR, ECE1, SNF8, EIF3F, THG1L, MLXIP, SUPT4H1, MRPL39, LHX8, FOXD1, SNAPC1, SOX12, SAP18, GTF2H3, EIF2B1, HOXB3, TAF10, MNAT1, CD55, EIF4G3, NOTCH1, HOXD8, HOXB2, DHX29, GO:0010467 gene expression 40 16,13 0,036 9130019O22RIK, RPS17, TRPS1, RPS4Y2, MNT, RPS13, SETD8, EAF2 1,35 0,750

TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, TIMP2, MEIS1, AHRR, SNF8, INSIG1, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, SAP18, GTF2H3, NPR3, UBE2L3, SFMBT1, HOXB3, TAF10, MNAT1, EIF4G3, NOTCH1, HOXD8, HOXB2, GO:0080090 regulation of primary metabolic process 41 16,53 0,040 9130019O22RIK, CD59B, TRPS1, MNT, SETD8, EAF2, PPP1R15B, UBE2E2 1,33 0,761 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, SNF8, INSIG1, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, SAP18, GTF2H3, NPR3, SFMBT1, INHBB, HOXB3, TAF10, MNAT1, EIF4G3, NOTCH1, HOXD8, HOXB2, GO:0031326 regulation of cellular biosynthetic process 38 15,32 0,047 9130019O22RIK, TRPS1, MNT, SETD8, EAF2, PPP1R15B 1,34 0,773 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, SNF8, INSIG1, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, SAP18, GTF2H3, NPR3, SFMBT1, INHBB, HOXB3, TAF10, MNAT1, EIF4G3, NOTCH1, HOXD8, HOXB2, GO:0009889 regulation of biosynthetic process 38 15,32 0,049 9130019O22RIK, TRPS1, MNT, SETD8, EAF2, PPP1R15B 1,33 0,765 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, SNF8, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, GTF2H3, SAP18, SFMBT1, INHBB, HOXB3, TAF10, MNAT1, EIF4G3, NOTCH1, HOXD8, HOXB2, 9130019O22RIK, TRPS1, MNT, GO:0010556 regulation of macromolecule biosynthetic process 36 14,52 0,068 SETD8, EAF2, PPP1R15B 1,31 0,828 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, SNF8, MLXIP, SUPT4H1, LHX8, FOXD1, SNAPC1, SOX12, GTF2H3, SAP18, HOXB3, TAF10, MNAT1, NOTCH1, HOXB2, GO:0006350 transcription 28 11,29 0,074 HOXD8, 9130019O22RIK, TRPS1, MNT, SETD8, EAF2 1,37 0,839 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, SNF8, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, SAP18, GTF2H3, SFMBT1, HOXB3, TAF10, MNAT1, EIF4G3, NOTCH1, HOXD8, HOXB2, CD59B, 9130019O22RIK, TRPS1, MNT, GO:0010468 regulation of gene expression 36 14,52 0,085 SETD8, EAF2, PPP1R15B 1,28 0,848

TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, SNF8, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, SAP18, GTF2H3, UBE2L3, SFMBT1, INHBB, HOXB3, TAF10, MNAT1, EIF4G3, NOTCH1, HOXD8, HOXB2, CD59B, GO:0060255 regulation of macromolecule metabolic process 39 15,73 0,092 9130019O22RIK, TRPS1, MNT, SETD8, EAF2, PPP1R15B, UBE2E2 1,26 0,858 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, TIMP2, MEIS1, AHRR, SNF8, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, GSC, SNAPC1, SOX12, GTF2H3, SAP18, NPR3, SFMBT1, HOXB3, TAF10, MNAT1, NOTCH1, HOXD8, HOXB2, 9130019O22RIK, TRPS1, MNT, SETD8, GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic34 acid13,71 metabolic0,122 processEAF2 1,25 0,871 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, TIMP2, MEIS1, AHRR, SNF8, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, GSC, SNAPC1, SOX12, GTF2H3, SAP18, NPR3, SFMBT1, HOXB3, TAF10, MNAT1, NOTCH1, HOXD8, HOXB2, 9130019O22RIK, TRPS1, MNT, SETD8, GO:0051171 regulation of nitrogen compound metabolic process 34 13,71 0,132 EAF2 1,24 0,883

TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, MEIS1, AHRR, SNF8, CREG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, GSC, SNAPC1, SOX12, GTF2H3, SAP18, SFMBT1, HOXB3, TAF10, GO:0045449 regulation of transcription 32 12,90 0,141 MNAT1, NOTCH1, HOXB2, HOXD8, 9130019O22RIK, TRPS1, MNT, SETD8, EAF2 1,25 0,890

TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, PTTG1, MEIS1, SART1, FANCL, AHRR, METTL3, SNF8, THG1L, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, ATP5J, UPF1, SNAPC1, SOX12, SAP18, GTF2H3, HOXB3, TAF10, MNAT1, ATP6V1A, EIF4G3, NOTCH1, HOXD8, HOXB2, GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic40 process16,13 0,142 ATP2A2, 9130019O22RIK, TRPS1, MNT, SETD8, EAF2, PAICS 1,20 0,889

TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, PTTG1, MEIS1, SART1, FAH, FANCL, AHRR, METTL3, SNF8, THG1L, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, ATP5J, UPF1, SNAPC1, SOX12, SAP18, GTF2H3, HOXB3, ATP6V1A, TAF10, MNAT1, EIF4G3, GLUL, NOTCH1, GO:0034641 cellular nitrogen compound metabolic process 42 16,94 0,174 HOXD8, HOXB2, ATP2A2, 9130019O22RIK, TRPS1, MNT, SETD8, EAF2, PAICS 1,17 0,915 TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, PTTG1, MEIS1, SART1, FAH, FANCL, AHRR, METTL3, SNF8, THG1L, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, ATP5J, UPF1, SNAPC1, SOX12, SAP18, GTF2H3, HOXB3, ATP6V1A, TAF10, MNAT1, EIF4G3, GLUL, NOTCH1, GO:0006807 nitrogen compound metabolic process 42 16,94 0,231 HOXD8, HOXB2, ATP2A2, 9130019O22RIK, TRPS1, MNT, SETD8, EAF2, PAICS 1,14 0,942

GSC, ELF2, GLIS2, ARNT2, GTF2H3, SAP18, PAX3, MEIS1, HOXB3, MNAT1, AHRR, NOTCH1, GO:0006355 regulation of transcription, DNA-dependent 21 8,47 0,236 HOXB2, HOXD8, 9130019O22RIK, TRPS1, CREG1, SNF8, MNT, LHX8, FOXD1 1,24 0,944

GSC, ELF2, GLIS2, ARNT2, GTF2H3, SAP18, PAX3, MEIS1, HOXB3, MNAT1, AHRR, NOTCH1, GO:0051252 regulation of RNA metabolic process 21 8,47 0,258 HOXB2, HOXD8, 9130019O22RIK, TRPS1, CREG1, SNF8, MNT, LHX8, FOXD1 1,22 0,950

MORFOGÉNESIS ES: 1,19 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0001763 morphogenesis of a branching structure 6 2,42 0,015 NOTCH1, LAMA5, GRB2, TGFBR2, PML, FOXD1 4,16 0,732 GO:0048754 branching morphogenesis of a tube 5 2,02 0,022 NOTCH1, LAMA5, TGFBR2, PML, FOXD1 4,66 0,755 GO:0035239 tube morphogenesis 6 2,42 0,047 NOTCH1, LAMA5, TGFBR2, PML, PAX3, FOXD1 3,04 0,778 GO:0002009 morphogenesis of an epithelium 6 2,42 0,049 NOTCH1, HOXB2, LAMA5, PML, PAX3, FOXD1 3,01 0,771 GO:0048729 tissue morphogenesis 7 2,82 0,057 NOTCH1, HOXB2, LAMA5, PML, PAX3, COL11A1, FOXD1 2,55 0,791 GO:0060429 epithelium development 7 2,82 0,092 NOTCH1, HOXB2, LAMA5, PML, PAX3, UBN1, FOXD1 2,24 0,855 GO:0035295 tube development 6 2,42 0,187 NOTCH1, LAMA5, TGFBR2, PML, PAX3, FOXD1 1,97 0,926 GO:0009888 tissue development 9 3,63 0,449 HOXB3, NOTCH1, HOXB2, LAMA5, PML, PAX3, UBN1, COL11A1, FOXD1 1,22 0,992

CATABOLISMO DE PROTEÍNAS ES: 1,13 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini FANCL, USPL1, DERL2, ENC1, RABGEF1, USP11, UBA5, ADAM19, UBE2L3, OTUB2, CISH, GO:0051603 proteolysis involved in cellular protein catabolic process12 4,84 0,044 UBE2E2 1,95 0,781 FANCL, USPL1, DERL2, ENC1, RABGEF1, USP11, UBA5, ADAM19, UBE2L3, OTUB2, CISH, GO:0044257 cellular protein catabolic process 12 4,84 0,045 UBE2E2 1,94 0,775 DERL2, USPL1, UPF1, ENC1, UBA5, UBE2L3, OTUB2, CISH, FANCL, RABGEF1, USP11, GO:0044265 cellular macromolecule catabolic process 13 5,24 0,048 ADAM19, UBE2E2 1,85 0,769 FANCL, USPL1, DERL2, ENC1, RABGEF1, USP11, UBA5, ADAM19, UBE2L3, OTUB2, CISH, GO:0030163 protein catabolic process 12 4,84 0,055 UBE2E2 1,87 0,789

GO:0019941 modification-dependent protein catabolic process 11 4,44 0,068 FANCL, USPL1, DERL2, ENC1, RABGEF1, USP11, UBA5, UBE2L3, OTUB2, CISH, UBE2E2 1,88 0,822

GO:0043632 modification-dependent macromolecule catabolic process11 4,44 0,068 FANCL, USPL1, DERL2, ENC1, RABGEF1, USP11, UBA5, UBE2L3, OTUB2, CISH, UBE2E2 1,88 0,822 DERL2, USPL1, UPF1, ENC1, UBA5, UBE2L3, OTUB2, CISH, FANCL, RABGEF1, USP11, GO:0009057 macromolecule catabolic process 13 5,24 0,073 ADAM19, UBE2E2 1,72 0,841 USPL1, DERL2, UPF1, ENC1, AMACR, UBA5, UBE2L3, OTUB2, CISH, FAH, FANCL, RABGEF1, GO:0044248 cellular catabolic process 15 6,05 0,108 USP11, ADAM19, UBE2E2 1,53 0,876 USPL1, DERL2, UPF1, ENC1, AMACR, UBA5, ADH7, UBE2L3, OTUB2, CISH, FAH, FANCL, GO:0009056 catabolic process 17 6,85 0,140 RABGEF1, USP11, ADAM19, UBE2E2, OXR1 1,42 0,891 USPL1, DERL2, ENC1, UBA5, UBE2L3, OTUB2, CISH, QPCT, FANCL, CD55, ECE1, RABGEF1, GO:0006508 proteolysis 16 6,45 0,206 USP11, ADAM19, UBE2E2, CTSF 1,34 0,936 RESPUESTA A ESTRÉS ES: 0,98 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini FANCL, CDKN1A, AHRR, DERL2, UPF1, GSDMD, PML, GTF2H3, PTTG1, PPP1R15B, EIF2B1, GO:0051716 cellular response to stimulus 12 4,84 0,055 PHLDA3 1,87 0,789 GO:0033554 cellular response to stress 9 3,63 0,094 FANCL, CDKN1A, DERL2, UPF1, PML, GTF2H3, PTTG1, PPP1R15B, PHLDA3 1,93 0,851 GO:0006974 response to DNA damage stimulus 7 2,82 0,113 FANCL, CDKN1A, UPF1, PML, GTF2H3, PTTG1, PHLDA3 2,11 0,866 DERL2, UPF1, TGFBR2, ARNT2, PML, GTF2H3, PTTG1, EIF2B1, FANCL, CD55, CDKN1A, GO:0006950 response to stress 18 7,26 0,198 ECE1, INSIG1, TFPI, TRP53INP1, PPP1R15B, PHLDA3, AHSA1 1,32 0,931

DESARROLLO Y DIFERENCIACIÓN CELULAR ES: 0,9 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GSC, TGFBR2, PML, PAX3, MEIS1, MFN2, HOXB3, NOTCH1, HOXB2, HOXD8, LAMA5, GO:0009887 organ morphogenesis 15 6,05 0,008 INSIG1, LHX8, COL11A1, FOXD1 2,19 0,621

CCK, CADM1, GRB2, GLIS2, ARNT2, PML, PAX3, TIMP2, MEIS1, ECE1, INSIG1, SH2B3, LHX8, FOXD1, COL11A1, DNAJA3, GSC, TGFBR2, NID1, ARHGAP24, UBN1, ANXA4, EIF2B1, GO:0048731 system development 32 12,90 0,055 HOXB3, MFN2, TAF10, MNAT1, NOTCH1, HOXD8, HOXB2, LAMA5, ADAM19 1,37 0,794

CCK, CADM1, GRB2, GLIS2, ARNT2, PML, PAX3, TIMP2, MEIS1, ECE1, INSIG1, SH2B3, LHX8, FOXD1, COL11A1, DNAJA3, GSC, TGFBR2, NID1, ARHGAP24, UBN1, ANXA4, EIF2B1, GO:0048856 anatomical structure development 32 12,90 0,111 HOXB3, MFN2, TAF10, MNAT1, NOTCH1, HOXD8, HOXB2, LAMA5, ADAM19 1,28 0,865 CCK, CADM1, GRB2, GLIS2, NNAT, ARNT2, PML, PAX3, TIMP2, MEIS1, ECE1, INSIG1, PTPLA, SH2B3, LHX8, FOXD1, COL11A1, DNAJA3, GSC, ENC1, TGFBR2, NID1, ARHGAP24, UBN1, ANXA4, EIF2B1, HOXB3, MFN2, TAF10, MNAT1, NOTCH1, HOXD8, HOXB2, LAMA5, GO:0007275 multicellular organismal development 36 14,52 0,125 IFT81, ADAM19 1,24 0,875 CCK, GSC, GRB2, TGFBR2, PML, PAX3, ARHGAP24, MEIS1, MFN2, HOXB3, NOTCH1, GO:0009653 anatomical structure morphogenesis 18 7,26 0,138 HOXB2, HOXD8, LAMA5, INSIG1, LHX8, FOXD1, COL11A1 1,40 0,892 GRB2, PML, PAX3, MEIS1, INSIG1, SH2B3, LHX8, FOXD1, COL11A1, DNAJA3, GSC, TGFBR2, NID1, ARHGAP24, ANXA4, UBN1, HOXB3, MFN2, MNAT1, TAF10, NOTCH1, HOXB2, GO:0048513 organ development 25 10,08 0,139 HOXD8, LAMA5, ADAM19 1,30 0,892 CCK, CADM1, GRB2, GLIS2, NNAT, ARNT2, PML, PAX3, TIMP2, MEIS1, ECE1, INSIG1, PTPLA, SH2B3, LHX8, COL11A1, FOXD1, DNAJA3, GSC, ENC1, TGFBR2, NID1, ARHGAP24, UBN1, ANXA4, EIF2B1, HOXB3, MFN2, TAF10, MNAT1, NOTCH1, HOXD8, HOXB2, RGS2, GO:0032502 developmental process 38 15,32 0,156 LAMA5, MNT, IFT81, ADAM19 1,20 0,910 CCK, CADM1, GRB2, GLIS2, TGFBR2, PML, PAX3, TIMP2, ARHGAP24, UBN1, EIF2B1, MEIS1, MFN2, TAF10, NOTCH1, RGS2, LAMA5, SH2B3, IFT81, LHX8, FOXD1, COL11A1, GO:0048869 cellular developmental process 23 9,27 0,244 DNAJA3 1,22 0,947

CCK, CADM1, GRB2, GLIS2, TGFBR2, PML, PAX3, TIMP2, ARHGAP24, UBN1, EIF2B1, GO:0030154 cell differentiation 22 8,87 0,257 MEIS1, TAF10, NOTCH1, RGS2, LAMA5, SH2B3, IFT81, LHX8, FOXD1, COL11A1, DNAJA3 1,22 0,950

CCK, FUT8, CADM1, GRB2, GLIS2, NNAT, ARNT2, PML, NTAN1, PAX3, TIMP2, MEIS1, FANCL, ECE1, INSIG1, PTPLA, SH2B3, LHX8, COL11A1, FOXD1, DNAJA3, GSC, TGFBR2, ENC1, NID1, NPR3, ARHGAP24, UBN1, ANXA4, EIF2B1, HOXB3, MFN2, TAF10, MNAT1, GO:0032501 multicellular organismal process 45 18,15 0,853 NOTCH1, HOXD8, HOXB2, ZFP105, RGS2, LAMA5, GRIA1, TFPI, IFT81, VAMP2, ADAM19 0,90 1,000 REGULACIÓN DE PROCESOS BIOLÓGICOS ES: 0,71 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini TAF1B, ELF2, GLIS2, ARNT2, PML, PAX3, TIMP2, MEIS1, AHRR, SNF8, CREG1, INSIG1, MLXIP, SUPT4H1, LHX8, FOXD1, DNAJA3, UPF1, GSC, SNAPC1, SOX12, TGFBR2, SAP18, GTF2H3, NPR3, UBE2L3, SFMBT1, CISH, INHBB, HOXB3, SH3BP5, TAF10, MNAT1, EIF4G3, NOTCH1, CDKN1A, HOXD8, HOXB2, 9130019O22RIK, CD59B, TRPS1, MNT, SETD8, EAF2, GO:0019222 regulation of metabolic process 46 18,55 0,021 PPP1R15B, UBE2E2 1,36 0,806

TAF1B, ELF2, CADM1, PLEKHM1, IGFBP6, ARNT2, PAX3, NRADD, FANCL, CREG1, INSIG1, GSC, SNAPC1, SOX12, GTF2H3, PDE10A, ARHGAP24, MFN2, INHBB, TAF10, CD38, EIF4G3, HOXD8, CD59B, ITGB1BP1, BTG3, MNT, VAMP2, PPP1R15B, DERL2, GRB2, GLIS2, NNAT, IL4RA, PML, TIMP2, GPRC5B, MEIS1, AHRR, ECE1, RGS12, ARPC3, SOS1, SNF8, TBC1D4, SH2B3, TRP53INP1, MLXIP, SUPT4H1, LHX8, PHLDA3, FOXD1, PPP2R2D, DNAJA3, TEC, UPF1, TGFBR2, SAP18, NID1, NPR3, UBE2L3, SFMBT1, CISH, SH3BP5, HOXB3, ATXN2, MNAT1, CD55, NOTCH1, CDKN1A, HOXB2, RGS2, 9130019O22RIK, ATP2A2, LAMA5, GO:0050789 regulation of biological process 79 31,85 0,345 TRPS1, SETD8, EAF2, UBE2E2 1,05 0,980

TAF1B, ELF2, CADM1, PLEKHM1, IGFBP6, ARNT2, PAX3, NRADD, FANCL, SLC24A3, CREG1, INSIG1, GSC, SNAPC1, SOX12, GTF2H3, PDE10A, ARHGAP24, MFN2, INHBB, TAF10, CD38, EIF4G3, HOXD8, CD59B, ITGB1BP1, BTG3, TFPI, MNT, VAMP2, PPP1R15B, DERL2, GRB2, GLIS2, NNAT, IL4RA, PML, ADH7, TIMP2, GPRC5B, MEIS1, AHRR, ECE1, RGS12, ARPC3, SOS1, SNF8, TBC1D4, SH2B3, TRP53INP1, MLXIP, SUPT4H1, LHX8, PHLDA3, FOXD1, PPP2R2D, DNAJA3, TEC, UPF1, TGFBR2, SAP18, NID1, NPR3, UBE2L3, SFMBT1, CISH, SH3BP5, HOXB3, ATXN2, MNAT1, CD55, NOTCH1, CDKN1A, HOXB2, RGS2, GO:0065007 biological regulation 82 33,06 0,414 9130019O22RIK, ATP2A2, LAMA5, TRPS1, SETD8, EAF2, UBE2E2 1,03 0,990

TAF1B, ELF2, PLEKHM1, IGFBP6, ARNT2, PAX3, NRADD, FANCL, CREG1, INSIG1, GSC, SNAPC1, SOX12, GTF2H3, PDE10A, ARHGAP24, MFN2, INHBB, TAF10, CD38, EIF4G3, HOXD8, CD59B, ITGB1BP1, BTG3, MNT, VAMP2, PPP1R15B, DERL2, GRB2, GLIS2, NNAT, IL4RA, PML, TIMP2, GPRC5B, MEIS1, AHRR, ECE1, RGS12, ARPC3, SOS1, SNF8, TBC1D4, SH2B3, TRP53INP1, MLXIP, SUPT4H1, LHX8, PHLDA3, FOXD1, PPP2R2D, DNAJA3, TEC, UPF1, TGFBR2, SAP18, NID1, NPR3, SFMBT1, CISH, SH3BP5, HOXB3, MNAT1, CDKN1A, GO:0050794 regulation of cellular process 73 29,44 0,489 NOTCH1, HOXB2, RGS2, 9130019O22RIK, LAMA5, TRPS1, SETD8, EAF2 1,02 0,994

MUERTE CELULAR ES: 0,7 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0006915 apoptosis 9 3,63 0,166 MNAT1, RNF130, TAF10, ECE1, CADM1, PML, TRP53INP1, PHLDA3, DNAJA3 1,68 0,909 GO:0012501 programmed cell death 9 3,63 0,177 MNAT1, RNF130, TAF10, ECE1, CADM1, PML, TRP53INP1, PHLDA3, DNAJA3 1,65 0,916 GO:0008219 cell death 9 3,63 0,227 MNAT1, RNF130, TAF10, ECE1, CADM1, PML, TRP53INP1, PHLDA3, DNAJA3 1,54 0,943 GO:0016265 death 9 3,63 0,246 MNAT1, RNF130, TAF10, ECE1, CADM1, PML, TRP53INP1, PHLDA3, DNAJA3 1,50 0,947

REGULACIÓN NEGATIVA DE LA EXPRESIÓN GÉNICA ES: 0,64 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0031324 negative regulation of cellular metabolic process 10 4,03 0,110 INHBB, AHRR, HOXD8, GSC, CD59B, GLIS2, TRPS1, INSIG1, PML, PAX3 1,77 0,869 GO:0031327 negative regulation of cellular biosynthetic process 9 3,63 0,122 INHBB, AHRR, HOXD8, GSC, GLIS2, TRPS1, INSIG1, PML, PAX3 1,81 0,874 GO:0009890 negative regulation of biosynthetic process 9 3,63 0,126 INHBB, AHRR, HOXD8, GSC, GLIS2, TRPS1, INSIG1, PML, PAX3 1,80 0,874 GO:0009892 negative regulation of metabolic process 10 4,03 0,160 INHBB, AHRR, HOXD8, GSC, CD59B, GLIS2, TRPS1, INSIG1, PML, PAX3 1,62 0,909 GO:0010558 negative regulation of macromolecule biosynthetic process8 3,23 0,204 INHBB, AHRR, HOXD8, GSC, GLIS2, TRPS1, PML, PAX3 1,66 0,936 GO:0010605 negative regulation of macromolecule metabolic process9 3,63 0,225 INHBB, AHRR, HOXD8, GSC, CD59B, GLIS2, TRPS1, PML, PAX3 1,54 0,945 GO:0016481 negative regulation of transcription 7 2,82 0,255 AHRR, HOXD8, GSC, GLIS2, TRPS1, PML, PAX3 1,63 0,950 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide7 and nucleic2,82 acid0,304 metabolicAHRR, process HOXD8, GSC, GLIS2, TRPS1, PML, PAX3 1,53 0,970 GO:0051172 negative regulation of nitrogen compound metabolic process7 2,82 0,312 AHRR, HOXD8, GSC, GLIS2, TRPS1, PML, PAX3 1,51 0,973 GO:0010629 negative regulation of gene expression 7 2,82 0,330 AHRR, HOXD8, GSC, GLIS2, TRPS1, PML, PAX3 1,48 0,977 GO:0045892 negative regulation of transcription, DNA-dependent 5 2,02 0,472 AHRR, HOXD8, GSC, TRPS1, PAX3 1,41 0,993 GO:0051253 negative regulation of RNA metabolic process 5 2,02 0,477 AHRR, HOXD8, GSC, TRPS1, PAX3 1,40 0,993

DESARROLLO DEL SISTEMA INMUNE ES: 0,61 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0030097 hemopoiesis 6 2,42 0,162 HOXB3, TGFBR2, PML, SH2B3, MEIS1, DNAJA3 2,07 0,909 GO:0048534 hemopoietic or lymphoid organ development 6 2,42 0,221 HOXB3, TGFBR2, PML, SH2B3, MEIS1, DNAJA3 1,85 0,943 GO:0002520 immune system development 6 2,42 0,251 HOXB3, TGFBR2, PML, SH2B3, MEIS1, DNAJA3 1,76 0,949 HOXB3, CD55, CADM1, H2-T9, CD34, TGFBR2, IL4RA, PML, SH2B3, H2-T10, MEIS1, GO:0002376 immune system process 11 4,44 0,422 DNAJA3 1,21 0,990

REGULACIÓN POSITIVA DE LA MUERTE CELULAR ES: 0,47 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0043068 positive regulation of programmed cell death 6 2,42 0,160 CDKN1A, NOTCH1, PML, TRP53INP1, EAF2, PHLDA3 2,08 0,911 GO:0010942 positive regulation of cell death 6 2,42 0,164 CDKN1A, NOTCH1, PML, TRP53INP1, EAF2, PHLDA3 2,06 0,909 GO:0043065 positive regulation of apoptosis 5 2,02 0,317 NOTCH1, PML, TRP53INP1, EAF2, PHLDA3 1,75 0,974 GO:0010941 regulation of cell death 8 3,23 0,468 CDKN1A, NOTCH1, CD59B, MNT, PML, TRP53INP1, EAF2, PHLDA3 1,23 0,992 GO:0042981 regulation of apoptosis 7 2,82 0,612 CDKN1A, NOTCH1, MNT, PML, TRP53INP1, EAF2, PHLDA3 1,10 0,998 GO:0043067 regulation of programmed cell death 7 2,82 0,625 CDKN1A, NOTCH1, MNT, PML, TRP53INP1, EAF2, PHLDA3 1,08 0,998

TRANSPORTE Y LOCALIZACIÓN PROTEICA ES: 0,42 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini

GO:0015031 protein transport 11 4,44 0,214 MFN2, PITPNM1, DERL2, TIMM9, SNF8, PML, RABGEF1, EXOC4, DOPEY1, SEC61G, EXOC1 1,46 0,941

GO:0045184 establishment of protein localization 11 4,44 0,221 MFN2, PITPNM1, DERL2, TIMM9, SNF8, PML, RABGEF1, EXOC4, DOPEY1, SEC61G, EXOC1 1,45 0,944

GO:0008104 protein localization 11 4,44 0,363 MFN2, PITPNM1, DERL2, TIMM9, SNF8, PML, RABGEF1, EXOC4, DOPEY1, SEC61G, EXOC1 1,27 0,984 GO:0006886 intracellular protein transport 5 2,02 0,390 MFN2, DERL2, TIMM9, PML, SEC61G 1,57 0,988 GO:0051649 establishment of localization in cell 9 3,63 0,400 MFN2, DERL2, TIMM9, PML, EXOC4, MLXIP, VAMP2, SEC61G, EXOC1 1,28 0,989 GO:0034613 cellular protein localization 5 2,02 0,449 MFN2, DERL2, TIMM9, PML, SEC61G 1,45 0,992 GO:0070727 cellular macromolecule localization 5 2,02 0,454 MFN2, DERL2, TIMM9, PML, SEC61G 1,44 0,992 MFN2, PITPNM1, DERL2, TIMM9, SNF8, PML, RABGEF1, EXOC4, DOPEY1, SEC61G, GO:0033036 macromolecule localization 12 4,84 0,461 SLCO2A1, EXOC1 1,15 0,992 GO:0051641 cellular localization 9 3,63 0,491 MFN2, DERL2, TIMM9, PML, EXOC4, MLXIP, VAMP2, SEC61G, EXOC1 1,18 0,993 GO:0046907 intracellular transport 6 2,42 0,553 MFN2, DERL2, TIMM9, PML, MLXIP, SEC61G 1,21 0,997

MIGRACIÓN ES: 0,38 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0016477 cell migration 5 2,02 0,296 CCK, FUT8, LAMA5, CD34, PAX3 1,81 0,968 GO:0048870 cell motility 5 2,02 0,411 CCK, FUT8, LAMA5, CD34, PAX3 1,53 0,990 GO:0051674 localization of cell 5 2,02 0,411 CCK, FUT8, LAMA5, CD34, PAX3 1,53 0,990 GO:0006928 cell motion 6 2,42 0,412 CCK, FUT8, LAMA5, CD34, PAX3, FOXD1 1,42 0,990 GO:0040011 locomotion 5 2,02 0,604 CCK, FUT8, LAMA5, CD34, PAX3 1,19 0,998

METABOLISMO DEL FÓSFORO ES: 0,34 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini MAPKAPK5, TGFBR2, PML, MAPKAPK3, CAMKK2, MTMR2, ATP6V1A, VRK2, PTPLB, PTPLA, GO:0006793 phosphorus metabolic process 13 5,24 0,290 MYLK, ATP5J, TEC 1,30 0,966 MAPKAPK5, TGFBR2, PML, MAPKAPK3, CAMKK2, MTMR2, ATP6V1A, VRK2, PTPLB, PTPLA, GO:0006796 phosphate metabolic process 13 5,24 0,290 MYLK, ATP5J, TEC 1,30 0,966

GO:0016310 phosphorylation 10 4,03 0,441 ATP6V1A, VRK2, MAPKAPK5, TGFBR2, MAPKAPK3, PML, MYLK, TEC, CAMKK2, ATP5J 1,21 0,992 FUT8, MAPKAPK5, TGFBR2, MAPKAPK3, PML, NID1, UBE2L3, CAMKK2, MGAT1, VRK2, GO:0043412 biopolymer modification 17 6,85 0,446 METTL3, B3GALNT1, THG1L, PARP3, UBE2E2, MYLK, TEC 1,12 0,992 FUT8, MAPKAPK5, TGFBR2, MAPKAPK3, PML, NID1, UBE2L3, CAMKK2, MGAT1, VRK2, GO:0006464 protein modification process 15 6,05 0,590 B3GALNT1, PARP3, UBE2E2, MYLK, TEC 1,03 0,998 GO:0006468 protein amino acid phosphorylation 8 3,23 0,605 VRK2, MAPKAPK5, TGFBR2, MAPKAPK3, PML, MYLK, TEC, CAMKK2 1,08 0,998 VRK2, MAPKAPK5, TGFBR2, MAPKAPK3, PML, NID1, PARP3, UBE2L3, UBE2E2, MYLK, TEC, GO:0043687 post-translational protein modification 12 4,84 0,672 CAMKK2 0,99 0,999

REGULACIÓN POSITIVA DE LA EXPRESIÓN GÉNICA ES: 0,28 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0010604 positive regulation of macromolecule metabolic process9 3,63 0,440 AHRR, NOTCH1, GLIS2, ARNT2, PML, PAX3, EAF2, SUPT4H1, FOXD1 1,23 0,992 GO:0031325 positive regulation of cellular metabolic process 9 3,63 0,460 AHRR, NOTCH1, GLIS2, ARNT2, PML, PAX3, EAF2, SUPT4H1, FOXD1 1,21 0,992 GO:0045941 positive regulation of transcription 7 2,82 0,463 NOTCH1, GLIS2, ARNT2, PAX3, EAF2, SUPT4H1, FOXD1 1,28 0,992 GO:0010628 positive regulation of gene expression 7 2,82 0,489 NOTCH1, GLIS2, ARNT2, PAX3, EAF2, SUPT4H1, FOXD1 1,24 0,994 GO:0009893 positive regulation of metabolic process 9 3,63 0,527 AHRR, NOTCH1, GLIS2, ARNT2, PML, PAX3, EAF2, SUPT4H1, FOXD1 1,14 0,996 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide7 and nucleic2,82 acid0,533 metabolicNOTCH1, process GLIS2, ARNT2, PAX3, EAF2, SUPT4H1, FOXD1 1,19 0,996 GO:0051173 positive regulation of nitrogen compound metabolic process7 2,82 0,563 NOTCH1, GLIS2, ARNT2, PAX3, EAF2, SUPT4H1, FOXD1 1,15 0,997 GO:0010557 positive regulation of macromolecule biosynthetic process7 2,82 0,571 NOTCH1, GLIS2, ARNT2, PAX3, EAF2, SUPT4H1, FOXD1 1,15 0,997 GO:0031328 positive regulation of cellular biosynthetic process 7 2,82 0,611 NOTCH1, GLIS2, ARNT2, PAX3, EAF2, SUPT4H1, FOXD1 1,10 0,998 GO:0009891 positive regulation of biosynthetic process 7 2,82 0,619 NOTCH1, GLIS2, ARNT2, PAX3, EAF2, SUPT4H1, FOXD1 1,09 0,998

NEUROGÉNESIS ES: 0,27 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0022008 neurogenesis 8 3,23 0,419 NOTCH1, CCK, PAX3, TIMP2, LHX8, EIF2B1, MEIS1, FOXD1 1,29 0,990 GO:0048699 generation of neurons 7 2,82 0,507 NOTCH1, CCK, PAX3, TIMP2, LHX8, MEIS1, FOXD1 1,22 0,995 GO:0048468 cell development 8 3,23 0,555 NOTCH1, CCK, LAMA5, PAX3, LHX8, EIF2B1, COL11A1, FOXD1 1,14 0,997 GO:0030182 neuron differentiation 5 2,02 0,675 NOTCH1, CCK, PAX3, LHX8, FOXD1 1,09 0,999

PROCESOS REPRODUCTIVOS ES: 0,21 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0007276 gamete generation 5 2,02 0,528 FANCL, ZFP105, CADM1, RGS2, IFT81 1,31 0,996 GO:0022414 reproductive process 8 3,23 0,571 FANCL, NOTCH1, ZFP105, CADM1, RGS2, TGFBR2, IFT81, LHX8 1,12 0,997 GO:0000003 reproduction 8 3,23 0,578 FANCL, NOTCH1, ZFP105, CADM1, RGS2, TGFBR2, IFT81, LHX8 1,11 0,997 GO:0019953 sexual reproduction 5 2,02 0,650 FANCL, ZFP105, CADM1, RGS2, IFT81 1,12 0,999 GO:0048609 reproductive process in a multicellular organism 5 2,02 0,694 FANCL, ZFP105, CADM1, RGS2, IFT81 1,06 0,999 GO:0032504 multicellular organism reproduction 5 2,02 0,694 FANCL, ZFP105, CADM1, RGS2, IFT81 1,06 0,999

METABOLISMO DE ÁCIDOS ORGÁNICOS ES: 0,19 Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini GO:0019752 carboxylic acid metabolic process 6 2,42 0,646 GLUL, PTGIS, AMACR, MTHFSD, ADH7, FAH 1,09 0,999 GO:0043436 oxoacid metabolic process 6 2,42 0,646 GLUL, PTGIS, AMACR, MTHFSD, ADH7, FAH 1,09 0,999 GO:0006082 organic acid metabolic process 6 2,42 0,648 GLUL, PTGIS, AMACR, MTHFSD, ADH7, FAH 1,08 0,999 GO:0042180 cellular ketone metabolic process 6 2,42 0,668 GLUL, PTGIS, AMACR, MTHFSD, ADH7, FAH 1,06 0,999

TÉRMINOS GO NO AGRUPADOS Términos GO Nº Genes % p-value Genes anotados Fold Enrichment Benjamini

TUBB2B, CADM1, DAK, ARNT2, PTTG1, OTUB2, SART1, FAH, PTGIS, B3GALNT1, TIMM9, INSIG1, RABGEF1, ABCB10, MRPL39, ENC1, MGAT1, RNF130, GLUL, HOXD8, DHX29, RPS17, CD34, MNT, RPS13, VAMP2, SEC61G, PAM, DERL2, GRB2, MAPKAPK5, GSDMD, MAPKAPK3, UBA5, TIMP2, CCNG1, MEIS1, AHRR, ECE1, VRK2, METTL3, PTPLB, PTPLA, EIF3F, SNF8, LHX8, DNAJA4, DNAJA3, TEC, TGFBR2, SAP18, SYCE2, MTHFSD, UBE2L3, EMILIN2, HOXB3, CDKN1A, NOTCH1, HOXB2, ATP2A2, RGS2, 9130019O22RIK, LAMA5, GO:0009987 cellular process 126 50,8 0,001 1,18 0,662 SLC7A1, TRPS1, PARP3, EAF2, AHSA1, UBE2E2, MYLK, TAF1B, USPL1, ELF2, PAX3, CAMKK2, FANCL, CTTN, SLC24A3, USP11, COL11A1, ATP5J, SNAPC1, SOX12, GTF2H3, ARHGAP24, UBN1, MFN2, ATP6V1A, TAF10, EIF4G3, ITGB1BP1, RPS4Y2, IFT81, ADAM19, PPP1R15B, CKS1B, CCK, FUT8, GLIS2, PML, ADH7, SLC19A2, TPCN1, DCHS1, MTMR2, NUMA1, EXOC4, THG1L, PSTPIP1, SH2B3, TRP53INP1, MLXIP, SUPT4H1, THBS2, PHLDA3, FOXD1, EXOC1, UPF1, AMACR, NID1, EIF2B1, CISH, MNAT1, GRIA1, SETD8, PAICS

USPL1, DERL2, FUT8, MAPKAPK5, PML, MAPKAPK3, UBA5, OTUB2, CAMKK2, FANCL, VRK2, B3GALNT1, EIF3F, RABGEF1, USP11, MRPL39, DNAJA4, DNAJA3, TEC, ENC1, GO:0044267 cellular protein metabolic process 36 14,5 0,012 1,49 0,691 TGFBR2, NID1, UBE2L3, EIF2B1, CISH, MGAT1, EIF4G3, DHX29, RPS17, RPS4Y2, RPS13, PARP3, ADAM19, AHSA1, UBE2E2, MYLK DERL2, TGFBR2, PML, PAX3, TIMP2, FANCL, MFN2, CD38, CDKN1A, NOTCH1, LAMA5, GO:0042127 regulation of cell proliferation 13 5,2 0,021 2,10 0,775 EAF2, DNAJA3 CKS1B, UPF1, PML, SYCE2, PTTG1, CCNG1, MFN2, TAF10, MNAT1, NUMA1, CDKN1A, GO:0007049 cell cycle 14 5,6 0,024 1,99 0,714 RGS2, TRP53INP1, SETD8 GO:0040008 regulation of growth 8 3,2 0,028 ATXN2, DERL2, CREG1, TGFBR2, IGFBP6, PML, EAF2, CISH 2,71 0,737 GSC, GLIS2, IL4RA, TGFBR2, PML, PAX3, TIMP2, MEIS1, CISH, MFN2, INHBB, ATXN2, GO:0048519 negative regulation of biological process 24 9,7 0,029 AHRR, CDKN1A, NOTCH1, HOXD8, CD59B, ATP2A2, RGS2, TRPS1, BTG3, INSIG1, EAF2, 1,57 0,711 PHLDA3 GSC, GLIS2, IL4RA, TGFBR2, PML, PAX3, TIMP2, MEIS1, CISH, MFN2, INHBB, CDKN1A, GO:0048523 negative regulation of cellular process 22 8,9 0,032 1,60 0,718 NOTCH1, AHRR, HOXD8, CD59B, RGS2, TRPS1, BTG3, INSIG1, EAF2, PHLDA3 USPL1, DERL2, FUT8, MAPKAPK5, PML, MAPKAPK3, UBA5, OTUB2, CAMKK2, FANCL, VRK2, ECE1, B3GALNT1, EIF3F, RABGEF1, USP11, MRPL39, DNAJA4, DNAJA3, TEC, ENC1, GO:0019538 protein metabolic process 40 16,1 0,045 1,33 0,782 TGFBR2, NID1, UBE2L3, EIF2B1, CISH, QPCT, MGAT1, CD55, EIF4G3, DHX29, RPS17, RPS4Y2, RPS13, PARP3, ADAM19, AHSA1, UBE2E2, MYLK, CTSF GO:0007417 central nervous system development 9 3,6 0,062 MNAT1, NOTCH1, GSC, HOXB2, ARNT2, TGFBR2, PAX3, LHX8, EIF2B1 2,11 0,816 GSC, CCK, CADM1, GLIS2, TGFBR2, ARNT2, PAX3, TIMP2, EIF2B1, MEIS1, HOXB3, MNAT1, GO:0007399 nervous system development 16 6,5 0,066 1,62 0,826 NOTCH1, HOXB2, LHX8, FOXD1 GO:0006412 translation 8 3,2 0,075 EIF4G3, DHX29, RPS17, RPS4Y2, EIF3F, RPS13, MRPL39, EIF2B1 2,17 0,836 DERL2, GLIS2, IL4RA, TGFBR2, ARNT2, NNAT, PML, NID1, PAX3, INHBB, CD38, AHRR, GO:0048522 positive regulation of cellular process 22 8,9 0,077 1,45 0,841 CDKN1A, NOTCH1, ECE1, SOS1, TRP53INP1, EAF2, SUPT4H1, PHLDA3, FOXD1, DNAJA3 GO:0022402 cell cycle process 9 3,6 0,083 MFN2, TAF10, CDKN1A, PML, SYCE2, TRP53INP1, SETD8, PTTG1, CCNG1 1,99 0,852 DERL2, CADM1, GLIS2, IL4RA, TGFBR2, ARNT2, NNAT, PML, NID1, PAX3, INHBB, CD38, GO:0048518 positive regulation of biological process 24 9,7 0,087 AHRR, CD55, CDKN1A, NOTCH1, ECE1, SOS1, TRP53INP1, EAF2, SUPT4H1, PHLDA3, 1,39 0,852 FOXD1, DNAJA3 GO:0001655 urogenital system development 5 2,0 0,087 NOTCH1, LAMA5, NID1, FOXD1, ANXA4 2,97 0,848 GO:0016044 membrane organization 7 2,8 0,093 MFN2, CTTN, GRIA1, TIMM9, TGFBR2, RABGEF1, VAMP2 2,23 0,854 GO:0051301 cell division 7 2,8 0,105 CKS1B, NOTCH1, PSTPIP1, SYCE2, SETD8, PTTG1, CCNG1 2,16 0,871 GO:0008284 positive regulation of cell proliferation 7 2,8 0,109 CD38, CDKN1A, NOTCH1, DERL2, TGFBR2, PAX3, DNAJA3 2,14 0,874 GO:0051246 regulation of protein metabolic process 8 3,2 0,109 AHRR, EIF4G3, UPF1, CD59B, PML, UBE2L3, PPP1R15B, UBE2E2 1,98 0,872 GO:0007507 heart development 6 2,4 0,114 MNAT1, NOTCH1, TGFBR2, PAX3, ADAM19, COL11A1 2,33 0,865 GO:0008285 negative regulation of cell proliferation 6 2,4 0,115 MFN2, CDKN1A, TGFBR2, PML, EAF2, TIMP2 2,32 0,865 GO:0051093 negative regulation of developmental process 6 2,4 0,118 NOTCH1, TGFBR2, IL4RA, INSIG1, PML, MEIS1 2,30 0,869 GO:0055085 transmembrane transport 9 3,6 0,159 ATP6V1A, SLC24A3, SLC7A1, TIMM9, ABCB10, SLC19A2, SEC61G, TPCN1, ATP5J 1,70 0,911 GO:0006357 regulation of transcription from RNA polymerase II promoter11 4,4 0,170 AHRR, NOTCH1, ELF2, HOXD8, GSC, GLIS2, ARNT2, SNF8, PAX3, MEIS1, FOXD1 1,55 0,914 GO:0065009 regulation of molecular function 10 4,0 0,173 SH3BP5, MNAT1, TAF10, CDKN1A, TGFBR2, PML, TBC1D4, NPR3, CISH, DNAJA3 1,59 0,915 GO:0048732 gland development 5 2,0 0,191 HOXB3, NOTCH1, LAMA5, TGFBR2, PML 2,20 0,929 GO:0007155 cell adhesion 10 4,0 0,195 CADM1, LAMA5, CD34, ITGB1BP1, PSTPIP1, NID1, EMILIN2, COL11A1, THBS2, DCHS1 1,55 0,932

GO:0022610 biological adhesion 10 4,0 0,197 CADM1, LAMA5, CD34, ITGB1BP1, PSTPIP1, NID1, EMILIN2, COL11A1, THBS2, DCHS1 1,54 0,932 GO:0032268 regulation of cellular protein metabolic process 6 2,4 0,219 AHRR, EIF4G3, UPF1, CD59B, PML, PPP1R15B 1,86 0,944 GO:0032990 cell part morphogenesis 5 2,0 0,227 MFN2, NOTCH1, CCK, LAMA5, FOXD1 2,04 0,944 GO:0007389 pattern specification process 6 2,4 0,227 HOXB3, NOTCH1, HOXD8, GSC, HOXB2, TGFBR2 1,83 0,942 GO:0003002 regionalization 5 2,0 0,228 HOXB3, NOTCH1, HOXD8, GSC, HOXB2 2,03 0,941 GO:0007420 brain development 6 2,4 0,236 MNAT1, NOTCH1, GSC, HOXB2, TGFBR2, LHX8 1,81 0,945 GO:0048646 anatomical structure formation involved in morphogenesis7 2,8 0,242 MFN2, NOTCH1, GRB2, TGFBR2, PAX3, ARHGAP24, MEIS1 1,66 0,947 CCK, TUBB2B, CADM1, PML, PTTG1, CCNG1, MTMR2, CTTN, TIMM9, RABGEF1, MRPL39, GO:0016043 cellular component organization 26 10,5 0,251 FOXD1, COL11A1, DNAJA3, TGFBR2, SYCE2, SAP18, NID1, UBN1, MFN2, TAF10, NOTCH1, 1,19 0,948 GRIA1, LAMA5, SETD8, VAMP2 GO:0050790 regulation of catalytic activity 8 3,2 0,280 SH3BP5, MNAT1, CDKN1A, TGFBR2, PML, TBC1D4, NPR3, CISH 1,50 0,961 GO:0050793 regulation of developmental process 9 3,6 0,327 NOTCH1, LAMA5, TGFBR2, IL4RA, INSIG1, PML, EAF2, TIMP2, MEIS1 1,37 0,977 GO:0007423 sensory organ development 5 2,0 0,340 MFN2, GSC, INSIG1, COL11A1, MEIS1 1,69 0,979 DERL2, CCK, CADM1, GSDMD, IL4RA, ARNT2, NNAT, PML, NTAN1, PTTG1, FANCL, AHRR, GO:0050896 response to stimulus 31 12,5 0,364 ECE1, INSIG1, TRP53INP1, H2-T10, LHX8, PHLDA3, UPF1, TGFBR2, GTF2H3, EIF2B1, 1,10 0,984 INHBB, MNAT1, CD55, GLUL, CDKN1A, GRIA1, H2-T9, TFPI, PPP1R15B, AHSA1 GO:0001701 in utero embryonic development 5 2,0 0,367 MFN2, NOTCH1, GRB2, ARNT2, TGFBR2 1,62 0,984 GO:0007167 enzyme linked receptor protein signaling pathway 5 2,0 0,382 FUT8, GRB2, SOS1, TGFBR2, PML 1,59 0,987 GO:0010646 regulation of cell communication 11 4,4 0,391 INHBB, ECE1, GSC, RGS2, GRB2, SOS1, NNAT, TBC1D4, TIMP2, PHLDA3, CISH 1,24 0,988 GO:0051239 regulation of multicellular organismal process 11 4,4 0,401 INHBB, ATXN2, NOTCH1, ATP2A2, LAMA5, TGFBR2, IL4RA, PML, EAF2, TIMP2, MEIS1 1,23 0,989 GO:0046483 heterocycle metabolic process 5 2,0 0,418 ATP6V1A, ATP2A2, MTHFSD, PAICS, ATP5J 1,51 0,990 GO:0016192 vesicle-mediated transport 7 2,8 0,445 CTTN, GRIA1, TGFBR2, RABGEF1, EXOC4, VAMP2, EXOC1 1,30 0,992 GO:0045595 regulation of cell differentiation 6 2,4 0,455 NOTCH1, TGFBR2, IL4RA, INSIG1, TIMP2, MEIS1 1,35 0,992 GO:0044271 nitrogen compound biosynthetic process 5 2,0 0,457 ATP6V1A, GLUL, ATP2A2, PAICS, ATP5J 1,44 0,992 GO:0009966 regulation of signal transduction 9 3,6 0,489 ECE1, GSC, RGS2, GRB2, SOS1, TBC1D4, TIMP2, PHLDA3, CISH 1,18 0,994 DERL2, CCK, FUT8, PML, PAX3, SLC19A2, TPCN1, SLCO2A1, SLC1A5, CTTN, SLC24A3, SNF8, GO:0051179 localization 32 12,9 0,490 TIMM9, RABGEF1, EXOC4, ABCB10, MLXIP, DOPEY1, EXOC1, ATP5J, TGFBR2, SLC6A15, 1,04 0,993 MFN2, PITPNM1, ATP6V1A, ATP2A2, GRIA1, LAMA5, CD34, SLC7A1, VAMP2, SEC61G GO:0016070 RNA metabolic process 9 3,6 0,491 TAF1B, MNAT1, TAF10, EIF4G3, UPF1, METTL3, THG1L, GTF2H3, SART1 1,18 0,993 GO:0022403 cell cycle phase 5 2,0 0,521 TAF10, SYCE2, SETD8, PTTG1, CCNG1 1,32 0,995 GO:0048583 regulation of response to stimulus 5 2,0 0,526 CD55, CADM1, CD59B, TGFBR2, IL4RA 1,31 0,996 GO:0022607 cellular component assembly 7 2,8 0,548 MTMR2, TAF10, CADM1, TUBB2B, LAMA5, PML, SYCE2 1,17 0,996 GO:0042221 response to chemical stimulus 11 4,4 0,568 MNAT1, GLUL, AHRR, DERL2, ECE1, NNAT, ARNT2, TGFBR2, PML, PPP1R15B, EIF2B1 1,08 0,997 GO:0032989 cellular component morphogenesis 5 2,0 0,575 MFN2, NOTCH1, CCK, LAMA5, FOXD1 1,24 0,997 DERL2, PML, SLC19A2, TPCN1, SLCO2A1, SLC1A5, CTTN, SLC24A3, TIMM9, SNF8, GO:0006810 transport 27 10,9 0,604 RABGEF1, EXOC4, ABCB10, MLXIP, DOPEY1, ATP5J, EXOC1, TGFBR2, SLC6A15, MFN2, 1,00 0,998 PITPNM1, ATP6V1A, ATP2A2, GRIA1, SLC7A1, VAMP2, SEC61G GO:0007242 intracellular signaling cascade 11 4,4 0,608 SH3BP5, PLEKHM1, GRB2, SOS1, PML, SH2B3, NPR3, PHLDA3, CISH, DNAJA3, TEC 1,04 0,998 DERL2, PML, SLC19A2, TPCN1, SLCO2A1, SLC1A5, CTTN, SLC24A3, TIMM9, SNF8, GO:0051234 establishment of localization 27 10,9 0,619 RABGEF1, EXOC4, ABCB10, MLXIP, DOPEY1, ATP5J, EXOC1, TGFBR2, SLC6A15, MFN2, 0,99 0,998 PITPNM1, ATP6V1A, ATP2A2, GRIA1, SLC7A1, VAMP2, SEC61G GO:0051276 chromosome organization 5 2,0 0,685 SYCE2, SAP18, SETD8, PTTG1, UBN1 1,07 0,999 GO:0006259 DNA metabolic process 5 2,0 0,715 FANCL, UPF1, GTF2H3, PTTG1, DNAJA3 1,03 1,000 GO:0044085 cellular component biogenesis 7 2,8 0,717 MTMR2, TAF10, CADM1, TUBB2B, LAMA5, PML, SYCE2 0,98 1,000 GO:0065008 regulation of biological quality 12 4,8 0,749 DERL2, ECE1, ARPC3, ATP2A2, SLC24A3, PML, TFPI, ADH7, VAMP2, EAF2, NPR3, DNAJA3 0,93 1,000 GO:0005975 carbohydrate metabolic process 5 2,0 0,769 MGAT1, FUT8, B3GALNT1, DAK, STBD1 0,95 1,000 GO:0006996 organelle organization 11 4,4 0,799 MFN2, TIMM9, PML, SYCE2, SAP18, SETD8, MRPL39, PTTG1, CCNG1, UBN1, DNAJA3 0,88 1,000 GO:0010033 response to organic substance 5 2,0 0,835 GLUL, DERL2, NNAT, TGFBR2, EIF2B1 0,86 1,000 GO:0006812 cation transport 5 2,0 0,847 ATP6V1A, ATP2A2, SLC24A3, TPCN1, ATP5J 0,84 1,000 GO:0006811 ion transport 6 2,4 0,916 ATP6V1A, ATP2A2, GRIA1, SLC24A3, TPCN1, ATP5J 0,73 1,000 GO:0009605 response to external stimulus 5 2,0 0,939 INHBB, CD55, GSDMD, TGFBR2, TFPI 0,68 1,000 PLEKHM1, GRB2, ARNT2, PML, PDE10A, NPR3, GPRC5B, NRADD, ARHGAP24, CISH, GO:0007165 signal transduction 19 7,7 0,998 0,60 1,000 SH3BP5, AHRR, RGS12, SOS1, SH2B3, PHLDA3, PPP2R2D, DNAJA3, TEC GO:0007166 cell surface receptor linked signal transduction 11 4,4 1,000 NOTCH1, RGS2, FUT8, GRB2, SOS1, TGFBR2, PML, ADAM19, NPR3, GPRC5B, CISH 0,38 1,000 GO:0003008 system process 5 2,0 1,000 GRIA1, NTAN1, VAMP2, NPR3, LHX8 0,24 1,000