Journal of Personalized Medicine Review The Skeletal Muscle Emerges as a New Disease Target in Amyotrophic Lateral Sclerosis Oihane Pikatza-Menoio 1,2,† , Amaia Elicegui 1,2,† , Xabier Bengoetxea 1,† , Neia Naldaiz-Gastesi 1,2, Adolfo López de Munain 1,2,3,4 , Gorka Gerenu 1,2,5,‡, Francisco Javier Gil-Bea 1,2,‡ and Sonia Alonso-Martín 1,2,*,‡ 1 Neuromuscular Diseases Group, Neurosciences Area, Biodonostia Health Research Institute, 20014 Donostia/San Sebastián, Spain;
[email protected] (O.P.-M.);
[email protected] (A.E.);
[email protected] (X.B.);
[email protected] (N.N.-G.);
[email protected] (A.L.d.M.);
[email protected] (G.G.);
[email protected] (F.J.G.-B.) 2 CIBERNED, Carlos III Institute, Spanish Ministry of Economy & Competitiveness, 28031 Madrid, Spain 3 Department of Neurology, Donostialdea Integrated Health Organization, Osakidetza Basque Health Service, 20014 Donostia/San Sebastián, Spain 4 Department of Neurosciences, Faculty of Medicine and Nursery, University of the Basque Country UPV-EHU, 20014 Donostia/San Sebastián, Spain 5 Department of Physiology, University of the Basque Country UPV-EHU, 48940 Leioa, Spain * Correspondence:
[email protected] † Equal contribution. ‡ Equal contribution. Citation: Pikatza-Menoio, O.; Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that leads to Elicegui, A.; Bengoetxea, X.; progressive degeneration of motor neurons (MNs) and severe muscle atrophy without effective Naldaiz-Gastesi, N.; López de treatment. Most research on ALS has been focused on the study of MNs and supporting cells of Munain, A.; Gerenu, G.; Gil-Bea, F.J.; the central nervous system.