Anti-SIRPG Monoclonal Antibody, Clone OX119 (CABT-53873MH) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-SIRPG monoclonal antibody, clone OX119 (CABT-53873MH) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse anti Human CD172g antibody, clone OX119 recognizes human SIRP gamma, a 55kD signal regulatory protein which is a member of the immunoglobulin gene superfamily. SIRP gamma, also known as CD172g, is expressed on most T lymphocytes and a subset of B-cells but is absent on myeloid cells. CD172g has a truncated cytoplasmic tail, which is similar to SIRP beta, but unlike SIRP beta CD172g does not require DAP12 for expression at the cell surface. CD172g, like SIRP alpha, binds to CD47 inducing apoptosis. It is also involved in the negative regulation of receptor tyrosine kinase-coupled signalling. Flow Cytometry Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

Specificity SIRPG

Immunogen Purified recombinant SIRPgamma.CD4.

Isotype IgG1

Source/Host Mouse

Species Reactivity Human

Clone OX119

Conjugate Unconjugated

Applications FC; IP

Format Purified IgG - liquid

Size 200 μg

Preservative 0.09% Sodium Azide

Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Warnings For research purposes only

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name SIRPG signal-regulatory protein gamma [ Homo sapiens (human) ]

Official Symbol SIRPG

Synonyms SIRPG; signal-regulatory protein gamma; CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma; SIRP-gamma; SIRP beta 2; SIRP-beta-2; CD172g antigen; signal-regulatory protein beta 2; signal-regulatory protein beta-2; CD172 antigen-like family member B;

Entrez Gene ID 55423

Protein Refseq NP_001034597

UniProt ID Q9P1W8

Chromosome Location 20p13

Pathway Cell surface interactions at the vascular wall; Cell-Cell communication; Hemostasis; Osteoclast differentiation; Signal regulatory protein (SIRP) family interactions;

Function protein binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]