Scientific Program Book IMMUNOLOGY 2019™ The Annual Meeting of the American Association of Immunologists May 9–13, 2019 San Diego Convention Center San Diego, California

TABLE OF CONTENTS

Thursday Afternoon Sessions ...... 1

Friday Morning Sessions ...... 7 Friday Afternoon Sessions ...... 13 Friday Posters ...... 19

Saturday Morning Sessions ...... 43 Saturday Afternoon Sessions ...... 50 Saturday Posters ...... 56

Sunday Morning Sessions ...... 82 Sunday Afternoon Sessions ...... 88 Sunday Posters ...... 94

Monday Morning Sessions ...... 121

Speaker Disclosures ...... 127

Author/Speaker Index ...... 133

THURSDAY—PM THURSDAY AFTERNOON

MAY 9

T 1. MAST CELLS: PHENOTYPE TO FUNCTION 12:30 Human natural regulatory T cells recognize peptides of H the heavy constant region of immunoglobulins Block Symposium U presented by IgG+ B cells. L-E. Hsieh, J. Sidney, THU. 12:15 PM—ROOM 26AB N. Behnamfar, J.C. Burns, D. Boyle, G.S. Firestein, A. Sette and A. Franco. Sch. of Med., Univ. of CHAIRS: T. SUMPTER, T. KAWAKAMI California, San Diego and La Jolla Inst. for 12:15 Comprehensive characterization of the mast cell Immunology. (57.4) surface proteome. N.J. Shubin, K. Niino, 12:45 CD71+erythroid cells promote Tregs and via V. Kasprzak, R. James and A.M. Piliponsky. ectonucleotides CD39 and CD73 modulate T cell Seattle Children’s Res. Inst. (54.1) responses. S. Elahi, S. Shahbaz and P. Koleva. 12:30 Early life adversity programs mast cells toward a Univ. of Alberta, Canada. (57.5) hyperactive phenotype into adulthood. 1:00 Negative feedback control of autoimmunity by a novel N.C. Maradiaga, C. Pohl, E. Mackey and population of regulatory unconventional CD8+ T cells. A.J. Moeser. Michigan State Univ. (54.2) I. Marrero, H. Sheng, I. Maricic, S.S. Fanchiang, 12:45 Perinatal androgens drive sex differences in mast cell S. Zhang, D. Sant’Angelo and V. Kumar. Univ. of phenotype and severity of mast cell disease. California, San Diego and Rutgers Univ. (57.10) E. Mackey and A.J. Moeser. Michigan State Univ. 1:15 A wave of Foxp3+ regulatory T cell accumulation in (54.15) neonatal liver plays unique roles in maintaining 1:00 Skin microbiome regulates SCF level in Keratinocytes self-tolerance. Q. Ge and M. Li. Peking Univ., and defines mast cell maturation. C-C. Wu, Z. Wang China. (57.14) and A. Di Nardo. Univ. of California, San Diego. 1:30 LAG-3+-induced regulatory T cells confer infectious (54.16) tolerance with suppression of IFN-g response 1:15 Allergen-induced disulfide-linked dimers/oligomers of decoupled from reserved proliferation. C-T. Huang, histamine-releasing factor enhance mast cell A. Dutta, C-Y. Hung, T-C. Chen, C-Y. Lin, Y-C. Lin, activation. Y. Kawakami, K. Kasakura, T. Ando, C-S. Chang, T-A. Chen and Y-L. Huang. Chang Y. Kawakami and T. Kawakami. La Jolla Inst. for Gung Mem. Hosp., Taiwan. (57.16) Immunology and Atopy (Allergy) Res. Ctr., Juntendo 1:45 c-Maf-dependent Treg cell control of intestinal TH17 Univ. Grad. Sch. of Med., Japan. (54.4) cells and IgA establishes host-microbiota 1:30 Selective serotonin reuptake inhibitors suppress mast homeostasis. S. Rutz, C. Neumann, J. Blume, cell function. T. Haque and J. Ryan. Virginia A. Kalies and A. Scheffold. Genentech, Inc., Commonwealth Univ. (54.11) German Rheumatism Res. Ctr., Germany, The 1:45 STAT5b dimers and tetramers are critical for mast cell Walter and Eliza Hall Inst. of Med. Res. and function. K.N. Kiwanuka, J. Lin, W.J. Leonard and Christian Albrechts Univ., Germany. (57.19) J.J. Ryan. Virginia Commonwealth Univ. and NHLBI, 2:00 Recently alloactivated CD4+CD8-CD25+T regulatory NIH, MD. (54.13) cells express CD8alpha and are potent suppressor 2:00 Ceramide-CD300f interaction inhibits Mrgprb2- cells. B.M. Hall, N.D. Verma, C.M. Robinson, mediated mast cell activation and pseudo-allergic C. Wang, A. Sharland, G. Tran, P. Wilcox and drug reactions in mice. A. Takamori, T. Ando, S.J. Hodgkinson. Univ. of New South Wales, A. Kaitani, A. Maehara, K. Izawa, K. Okumura Australia and Sydney Univ., Australia. (57.20) and J. Kitaura. Juntendo Univ. Graduate Sch. of Med., Japan. (54.8) 3. MYELOID CELLS Block Symposium 2. TREGS AND TH17 THU. 12:15 PM—ROOM 31ABC Block Symposium CHAIRS: R.G. SCHERAGA, M. MESSMER THU. 12:15 PM—ROOM 30CDE 12:15 Myeloid responders to programmed cell death. CHAIRS: A. FRANCO, V. KUMAR M.N. Messmer, A.G. Snyder, M.Y. Gerner and 12:15 Phenotypic and functional characterisation of expanded A. Oberst. Univ. of Washington. (58.2) antigen-specific regulatory T cells towards clinical 12:30 TRPV4 mediates the macrophage phagocytic and translation. J. Bianchi, R.I. Azevedo, A.I.S. Vieira, cytokine response to leptin. R.G. Scheraga, D. Ligeiro, C.L. da Silva and J.F. de Lacerda. IMM, A. Perelas, S. Abraham, L. Grove, B.D. Southern, FMUL, CF, Lisbon, Spain, CSTL, IPST-IP, Spain and J. Crish and M. Olman. Cleveland Clin. (58.4) IST-iBB. (57.2)

1 THURSDAY—PM

12:45 Creatine shapes macrophage polarization by 1:15 TRAF3IP3 negatively regulates type I interferon reprogramming L-arginine metabolism. L. Ji, signaling by suppressing TBK1. M. Deng, X. Zhao, B. Zhang, L. Kang, W. Song, B. Zhao, J.W. Tam, H. Guo, L. Zhang, B.K. Davis, W. Xie, L. Chen and X. Hu. Inst. for Immunology and J. Brickey, S. Sun and J.P. Ting. Lineberger Sch. of Med., Tsinghua Univ., China, Sch. of Comprehensive Cancer Ctr., Univ. of North Pharmaceutical Sci., Tsinghua Univ., China, Carolina, Chapel Hill, Dept. of Biol., Franklin and Hospital for Special Surgery Res. Div. and the Marshall Col., Lancaster, PA and Univ. of Texas David Z. Rosensweig Genomics Ctr. and Tsinghua- MD Anderson Cancer Ctr. (64.12) Peking Center for Life Sci., School of Life Sci., 1:30 Induction of innate antiviral immunity through a novel Tsinghua Univ., China. (58.5) pattern recognition receptor, the RNA helicase 1:00 WITHDRAWN DHX16, is regulated by unanchored K48-linked 1:15 Itaconate inhibits alternative activation of macrophages poly-ubiquitin chains. A. Hage, P. Bharaj and by targeting Janus kinase 1. M.C. Runtsch and R. Rajsbaum. Univ. of Texas Med. Br. (64.16) L. O’Neill. Trinity Col. Dublin, Ireland. (58.11) 1:45 NME4 regulates TLR3 activation and type I IFN 1:30 IL-34 differentiation of immunosuppressive production through autophagy-dependent TRAF6 macrophage. K. Kelly-Scumpia, R. Shirazi and degradation. B. Sun, X.H. Zhao and R.H. Zhang. R. Modlin. Univ. of California, Los Angeles. (58.13) Shanghai Inst. of Biochemistry and Cell Biol., 1:45 Sympathetic nervous tone influences anti-tumor Chinese Acad. of Sci., China. (64.22) immunity by mediating accumulation of myeloid- 2:00 Dysregulated CARD9 signaling in neutrophils drives derived suppressor cells and regulatory T-cells. inflammation in a mouse model of neutrophilic J.T. Nevin, W.L. Corwin and P.K. Srivastava. dermatoses. S. Tartey and T-D. Kanneganti. St. Univ. of Connecticut Hlth. Ctr. (58.15) Jude Children’s Res. Hosp. (64.25) 2:00 Fatty acid transporter 2 regulates the suppressive functions of PMN-MDSC in cancer. F. Veglia, 5. CYTOKINE AND T CELL-BASED V. Tyurin, M. Blasi, A. De Leo, L. Donthireddy, IMMUNOTHERAPY C. DiRusso, P. Black, V. Kagan and D.I. Gabrilovich. The Wistar Inst., Univ. of Block Symposium Pittsburgh, Duke Univ. and Univ. of Nebraska- THU. 12:15 PM—ROOM 29ABCD Lincoln. (58.18) CHAIRS: M. KROGSGAARD, C. WARE 4. INNATE IMMUNE SENSING AND SIGNALING 12:15 A powerful ICOS agonist that enhances anti-tumor Block Symposium immune responses restored by immune checkpoint inhibitors. J. Gariepy, A. Prodeus, A. Sparkes, THU. 12:15 PM—ROOM 25ABC N. Fischer and S. Saha. Sunnybrook Res. Inst., Canada, Univ. of Toronto, Canada and McMaster CHAIRS: K. KOBAYASHI, E. AMIEL Univ., Canada. (71.5) 12:15 Role of NLRC5 and IRF1 in the induction of MHC class I. 12:30 A novel agonist of CD137 immune checkpoint stimulator S. Vijayan, T.B. Meissner, K-H. Lee, Y-J. Liu, serves as a cancer immunoprevention agent with I. Downs, T. Sidiq, C. Zhang, P.J. van den Elsen efficacy against various tumor types. L. Batra, and K.S. Kobayashi. Texas A&M Hlth. Sci. Ctr., H.B. Barsoumian, P. Shrestha, J.L. Hawthorne, Harvard Med. Sch. and Leiden Univ. Med. Ctr., W.S. Bowen, H. Zhao, N.K. Egilmez, The Netherlands. (64.20) J.G. Gomez-Gutierrez, H. Shirwan and 12:30 Syk-dependent glycolytic reprogramming in dendritic E.S. Yolcu. Inst. for Cellular Therapeutics, cells regulates IL-1-beta production to fungal- FasCure Therapeutics, LLC and Univ. of Louisville. associated ligands in a TLR-independent manner. (71.6) E. Amiel, P.M. Thwe, D. Fritz and J. Snyder. 12:45 Interleukin-15 in cancer immunotherapy: IL-15 receptor Univ. of Vermont and Tufts Univ. (64.2) complex versus soluble IL-15 in a cancer cell- 12:45 Regulation of GLI3 expression by TLR4 signaling. delivered murine leukemia model. A. Berger, S.J. Matissek and S.F. Elsawa. Univ. of New S. Colpitts, M. Seabrook, C. Furlonger, Hampshire. (64.14) M. Bendix, J. Moreau, W. McKillop, J. Medin and 1:00 NHR-49/PPARa regulates HLH-30/TFEB-mediated C.J. Paige. Ontario Cancer Inst., Canada and Med. innate immune response via a flavin-containing Col. of Wisconsin. (71.11) monooxygenase in C. elegans. K. Wani, 1:00 Lenolidamide and IL-15 enhance natural killer cell- S. Taubert and J. Irazoqui. Univ. of mediated immunity and augments the anti-tumor Massachusetts Med. Sch. and Univ. of British effect of an anti-CD30/CD16A bispecific antibody Columbia, Canada. (64.6) against Hodgkin’s lymphoma B cells. A. Manna, S. Aulakh, S. Ailawadhi, A. Chanan-Khan, T. Sher and A. Paulus. Mayo Clin. (71.12) 1:15 Rejection-resistant off-the-shelf T cells for adoptive cell therapy. F. Mo, M. Srinivasan, R. Ma, T.S. Smith, M.K. McKenna, E. Atilla, P. Ataca Atilla, H.E. Heslop, M.K. Brenner and M. Mamonkin. Baylor Col. of Med. (71.8)

2 THURSDAY—PM

1:30 Unbiased functional identification and therapeutic 3:00 Unmasking a killer: discovery of a that controls the targeting of T cell neoantigens in a spontaneous pathogenic activation of CD8+ T cells in type 1 murine squamous cell carcinoma. J.S. Dolina, diabetes. C. Ye, D.V. Serreze, Y-G. Chen and J. Lee, B. Peters and S.P. Schoenberger.La J.P. Driver. Univ. of Florida, Jackson Lab. and Jolla Inst. for Immunology. (71.14) Med. Col. of Wisconsin. (50.9) 1:45 Determinants of TCRa-b chain pairing in generating 3:15 A hypomorphic Ephb2 gene variant contributes to TCR diversity. H. Tanno, T.M. Gould, autoimmune diabetes in NOD mice associated with T R.E. Durrett, J.R. McDaniel, W. Cao, J. Gollihar, altered Mapk3 activities in B-lymphocytes. Q. Wang, H C. Steven, Y. Tanno, A.D. Ellington, G.C. Ippolito, H.D. Chapman, J.J. Racine and D. Serreze. W. Hildebrand, G. Georgiou and J.J. Goronzy. The Jackson Lab. (50.6) U Univ. of Texas at Austin, Stanford Univ. Sch. of Med. 3:30 Distinctions in gene-expression in PBMC from male and and The Univ. of Oklahoma Hlth. Sci. Ctr. (71.15) female SLE patients. M. Olferiev, D. Fernandez, 2:00 Covalent adaptor synNotch and chimeric antigen D. Greenman, M. Peng, K. Kirou and M.K. Crow. receptors for programmable antigen targeting. Hosp. for Special Surgery. (50.8) J.J. Lomueller, A. Butchy, Y. Tivon, M. Kvorjak, 3:45 X- inactivation maintenance is perturbed in N. Miskov-Zivanov, A. Deiters and O.J. Finn. Univ. T cells from lupus mouse models and human lupus of Pittsburgh. (71.18) patients. M. Anguera. Univ. of Pennsylvania. (50.2) 4:00 Epigenetic programming underpins B cell dysfunction in 6. BACK TO SCHOOL: A REVIEW OF FOUR human SLE. C. Scharer, E. Blalock, T. Mi, FAST-MOVING FIELDS B. Barwick, S. Jenks, B. Neary, D. Patterson, T. Deguchi, E-H. Lee, C. Wei, I. Sanz and Committee-Sponsored Session J.M. Boss. Emory Univ. Sch. of Med. (50.10) Sponsored by the AAI Program Committee 4:15 Developmental exposure to environmental toxicant trichloroethylene alters DNA methylation in — THU. 2:30 PM ROOM 33ABC polycomb binding regions in effector/ + CHAIRS: D. MASOPUST, J. M. BLANDER memory CD4 T cells from autoimmune-prone mice. S.J. Blossom, S. Byrum, C.L. Washam, This workshop intends to bring a broad audience up-to-date J.D. Patterson, K.K. Vyas and K.M. Gilbert. Univ. fi on a few emerging or rapidly changing elds or areas of of Arkansas for Med. Sci. (50.7) technological innovation. Expert lecturers will provide an overview of each trending topic with an emphasis on 8. LYMPHOCYTE DEVELOPMENT communicating big picture concepts. Block Symposium 2:30 Super antibodies: the fourth generation. D. Burton. Scripps Res. Inst. THU. 2:30 PM—ROOM 32AB 3:00 Cellular heterogeneity in the immune system: turning a CHAIRS: K.L. MEDINA, M. ANDERSON bug into a feature with single-cell genomics. A. Shalek. Massachusetts Inst. of Technol. 2:30 Hoxa9 silencing of p16ink4a is essential for murine 3:30 The complement system – new tricks for an old dog. lymphopoiesis. K.L. Medina and K.A. Gwin. Mayo J. Thurman. Univ. of Colorado. Clin. (53.20) 4:00 Myeloid cells: directors of the tumor immune 2:45 MicroRNA-142 is an essential negative regulator of B microenvironment. C. Hedrick. La Jolla Inst. for cell maturation and malignant transformation. Immunology. N.M. Graham, W-L. Wang, N. Magilnick, J. Lee, H. Wang, B. Zhang, G. Marcucci, M. Muschen, 7. BASIC AUTOIMMUNITY: GENETIC AND E. Reyes and M.P. Boldin. City of Hope Beckman NON-GENETIC TRIGGERS Res. Inst., Syst.s Biol., Beckman Res. Inst., City of Hope and Gehr Family Ctr. for Leukemia Res., Block Symposium Hematology Malignancies and Stem Cell Transplantation Inst. (53.22) THU. 2:30 PM—ROOM 30AB 3:00 Modulation of Id3 induces a fetal-specific HEB- CHAIRS: L. SHERMAN, J. BOSS dependent gamma delta T cell developmental 2:30 p38 MAP kinase signaling in microglia plays a sex- pathway in the adult mouse thymus. specific protective role in CNS autoimmunity. J.S. Selvaratnam and M.K. Anderson. D.N. Krementsov and M. McGill. Univ. of Sunnybrook Res. Inst., Canada and Univ. of Vermont. (50.3) Toronto, Canada. (53.14) 2:45 Pro-autoimmune genetic risk variant, PTPN22 3:15 Distinct CD28 signaling requirements determine the 1858C>T accelerates formation of tertiary lymphoid alternative fates of thymic agonist selection. structures in a mouse model of type 1 diabetes. M. Watanabe, F. Alkhaleel and R.J. Hodes. NCI, S.E. Schmiel, K. Marquardt and L.A. Sherman. NIH. (53.13) Scripps Res. Inst. (50.5)

3 THURSDAY—PM

3:30 A critical role for the Slam/SAP signaling pathway in the 10. IMMUNE MECHANISMS AT MUCOSAL SITES developmental programming of gd T cell function. Block Symposium J.E. Boyson, V.L. DeVault, S.K. Mistri, L. Mei, S.C. Musial, C. Spear, J.A. Dragon, A. Veillette THU. 2:30 PM—ROOM 30CDE and O. Dienz. Univ. of Vermont and McGill Univ., CHAIRS: C. NAGLER, B. KELSALL Canada. (53.21) 3:45 Cell-targeted steroid signaling in the thymus determines 2:30 Intestinal permeability and IgA provoke immune T cell repertoire strength. M.D. Taves, P. Mittelstadt, vasculitis linked to cardiovascular inflammation. D. Presman, G. Hager and J.D. Ashwell. NCI, NIH M. Noval Rivas, D. Wakita, M. Franklin, S. Chen, and Univ. de Buenos Aires, Argentina. (53.12) M. Yamashita, T.R. Crother, K. Shimada and 4:00 Regulation of thymic type I IFN expression and its role in M. Arditi. Cedars-Sinai Med. Ctr. (67.1) T cell development. O.C. Salgado Barrero, S.T. Lee, 2:45 TLR4 signaling regulates an inflammatory response to E.R. Breed and K.A. Hogquist. Ctr. for Immunology, food allergens. E. Campbell and C. Nagler. Univ. of Univ. of Minnesota. (53.16) Chicago. (67.6) 4:15 Perturbation of developmental hematopoiesis shapes 3:00 Vitamin A signaling regulates pathological epithelial cell lung ILC2 immune memory. D.A. Lopez and shedding via IL-18. N.R. Iyer and S. Vaishnava. A.E. Beaudin. Sch. of Natural Sci., UC Merced. Brown Univ. (67.14) (53.15) 3:15 BATF is an essential regulator of migratory ILC2 cell fate and function. M.M. Miller, P. Patel, K. Bao, 9. HEMATOPOIESIS AND T. Danhorn, B. O’Connor and R.L. Reinhardt. MYELOID DEVELOPMENT Natl. Jewish Hlth. and Duke Univ. Med. Ctr. (67.9) 3:30 Pulmonary resident effector CD4+ T cells fail to Block Symposium effectively utilize glycolysis. L.M. Roberts, THU. 2:30 PM—ROOM 25ABC T.J. Evans and C.M. Bosio. NIAID, NIH. (67.16) 3:45 Formation of human T cell mucosal resident memory CHAIRS: R.S. WELNER, J.O. MANILAY starts in early life with the intestines. T. Connors, 2:30 Sclerostin depletion may induce inflammation in the P. Thapa, M.C. Yopes, R.S. Guyer, M.M. Li, bone marrow. C. Donham, G. Loots and M.E. Snyder and D.L. Farber. Columbia Univ. J. Manilay. Univ. of California, Merced. (118.16) Med. Ctr. (67.21) 2:45 Bone marrow resident Tregs maintain stromal cell 4:00 Single-cell mRNA analysis of colon phagocyte function via IL-10. V. Camacho, S. Patel, heterogeneity identifies two major macrophage V. Matkins, H.R. Turnquist and R.S. Welner. developmental pathways. B. Kang, L.J. Alvarado, Univ. of Alabama, Birmingham and Univ. of M. Lehman, B-H. Kim, P. Li, H. Cho, J. He, Pittsburgh Sch. of Med. (118.14) A. Larochelle and B.L. Kelsall. NIAID, NIH, 3:00 Plasma cells are obligate enhancers of age-associated NHLBI, NIH, NIMH, NIH and NCI, NIH. (67.11) myeloid skewing. P. Pioli, D. Casero, E. Montecino- 4:15 High-dimensional immune atlas of second trimester Rodriguez, S.L. Morrison and K.A. Dorshkind. human intestinal immunity. L. Konnikova, Univ. of California, Los Angeles. (118.10) S. Stras, L. Werner, J. Toothaker, A. Oldham 3:15 IL7R regulates fetal tissue resident macrophage and D. Shouval. Univ. of Pittsburgh and Edmond development. G. Leung, T. McCann, and Lily Safra Children’s Hosp. (67.12) C.H. Valencia, A. Worthington, C. Forsberg and A.E. Beaudin. Univ. of California, Merced and Univ. 11. ADJUVANT, ANTIGEN PRESENTATION, AND of California, Santa Cruz. (118.13) PEPTIDE-BASED VACCINES 3:30 Histone Deacetylase 3 regulates the ontogeny and FOR IMMUNOTHERAPY maintenance of tissue-resident macrophages. Y. Yao, Q. Liu, F. Geissmann, L. Zhou and Block Symposium Q-S. Mi. Henry Ford Hlth. Sys. and Mem. Sloan THU. 2:30 PM—ROOM 29ABCD Kettering Cancer Ctr. (118.12) 3:45 Protein kinase C activates multiple pathways to induce CHAIRS: J. ARVELUND, B. LUI dendritic cell differentiation. C.A. Chavel and 2:30 Vasoactive intestinal peptide signaling–a novel immune K.P. Lee. Roswell Park Cancer Inst. (118.15) checkpoint in pancreatic ductal adenocarcinoma. 4:00 An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer S. Ravindranathan, Y. Li, S. Wang, M. Zaidi, switching during cDC1 development. P. Bagadia. G.B. Lesinski, B. El-Rayes and E.K. Waller. Washington Univ. Sch. of Med. in St. Louis. (118.9) Emory Univ. Sch. of Med. (70.8) 4:15 Merocytic dendritic cell: a new subset of conventional 2:45 Active cancer vaccine targeting carbohydrates for dendritic cells. C. Audiger and S. Lesage. Univ. of immunotherapy. V. Padler-Karavani, Montreal, Canada. (118.11) E.M. Reuven, S. Leviatan Ben-Arye, H. Yu, R. Duchi, A. Perota, S. Conchon, J-P. Soulillou, C. Galli and X. Chen. Tel Aviv Univ., Israel, Univ. of California, Davis, Avantea, Italy and INSERM, France. (70.14)

4 THURSDAY—PM

3:00 Induction of immune responses and clinical efficacy in a 3:15 Low-weight piglets show differences in intestinal pilot personalized trial of 26 multi-epitope microbiota, intestinal transcriptome and immune immunotherapy using long peptides Th1 and CD8 cell profile compared to high-weight piglets during simultaneously in progressive tumors. J.P. Marquez- the first two weeks of lactation. M. Blais, Manriquez, J.A. Matute-Briseno, S. Icedo-Zamora, B. Morissette, G. Talbot, F. Beaudoin, A. Durazo-Acuna, PA. Lucero-Diaz, M.O. Rosas- K. Deschene, L. Lo Verso, N. Bissonnette, Delgado and A. Camacho-Hernandez. CICS USA. K. Lauzon, F. Guay and M. Lessard. Agr. and T (70.17) Agri-Food Canada, Canada and Univ. Laval. (73.13) H 3:15 Immunotherapy with tumor membrane vesicle-based 3:30 Equine bone marrow mesenchymal stromal cells inhibit cancer vaccine inhibits metastatic tumor growth in reactive oxygen species production by neutrophils U lung cancer model. R. Bommireddy, H.L. Huang, without affecting other important microbicidal L.E. Munoz, A.P. Menon, S. Ramalingam and functions. C. Henriquez, G. Espinosa, P. Selvaraj. Emory Univ. Sch. of Med. (70.7) A. Schenffeldt, P. Alarcon, G. Gajardo, A. Plaza, 3:30 Natural adjuvants for in situ vaccination lymphoma V. Caffi, B. Uberti and G. Moran. Univ. Austral de immunotherapy. M. Aleynick, P. Peng, Chile, Chile. (73.19) R. Upadhyay, L. Hammerich, V. Roudko, 3:45 T cells responses during resolving hepacivirus A M. Yellin and J. Brody. Icahn Sch. of Med., Mount infection, a surrogate animal model for human Sinai and Celldex Therapeutics. (70.9) hepatitis C. F. Gimenez, R.H. Mealey and 3:45 Defining the signaling and downstream regulation of J.D. Ramsay. Washington State Univ., Col. of Vet. neutrophil-dendritic cell development for adjunctive Med. (73.20) therapy. M. Gui, J.S. Fites, D. Sykes, M.K. Mansour 4:00 Disease tolerance and immune response in bovine and B.S. Klein. Univ. of Wisconsin, Madison and trypanosomiasis is mediated by CD14 promoter Massachusetts Gen. Hosp. (70.19) gene. O. Morenikeji and B. Thomas. Rochester 4:00 Monocytes outperform ex vivo generated dendritic cells Instit. of Technol. (73.17) as cellular vaccines to trigger cytotoxic T lymphocyte 4:15 Characterization of bovine gd T cells phenotype responses against cancer in pre-clinical models. following Mycobacterium bovis vaccination or M-N. Huang, L.T. Nicholson, K.A. Batich, virulent infection. M. Guerra-Maupome, D. Kopin, A.M. Swartz, J.H. Sampson and M.V. Palmer, R. Waters and J.L. McGill. Iowa M.D. Gunn. Duke Univ. Sch. of Med. (70.20) State Univ. and USDA-ARS, Natl. Animal Dis. Ctr. 4:15 Albumin-Flt3L-induced cross-presenting dendritic cells (73.16) promote neoantigen-specific antitumor immunity and subsequent tumor control in murine models of cancer. 13. INFLUENZA VIRUS AND THE B.K. Lam, D. Esquivel, B. Lee, M. Tan, T.C. Wu and IMMUNE RESPONSE C-F. Hung. Johns Hopkins Univ. Sch. of Med. (70.11) Block Symposium

12. VETERINARY AND THU. 2:30 PM—ROOM 31ABC COMPARATIVE IMMUNOLOGY CHAIRS: J. KOHLMEIER, T. STRUTT Block Symposium 2:30 CD8+ T cells require IL-27R for optimal generation of an THU. 2:30 PM—ROOM 26AB effector response during influenza infection. P. Dunbar, Z-R.T. Li, J. Lobby, S.L. Hayward, CHAIRS: J.C. TELFER, I. SALINAS L. Lawrence and J.E. Kohlmeier. Emory Univ. 2:30 Evolution of the AID/APOBEC family of cytidine Sch. of Med. (74.1) deaminases in lampreys. M. Hirano, Y. Sutoh, 2:45 CD4+ cell-derived IL-2 synergizes with influenza S. Das and M. Cooper. Emory Univ. Sch. of Med. infection to exacerbate lung inflammation. (73.1) T.M. Strutt and A. Gilchrist. Univ. of Central 2:45 On the evolutionary origins of Cd1d and the type I, semi- Florida. (74.2) invariant natural killer T cells. N.C. Suryadevara, 3:00 IFN-lambda modulates dendritic cells to facilitate A. Kumar, P. Chimski, K. Oh, C. Caster, protective T cell immunity during influenza A virus R.R. Truman, L. Ren, M. Criscitiello and infection. E.A. Hemann, R. Green, B. Turnbull, S. Joyce. Vanderbilt Univ. Med. Ctr., Texas A&M R.A. Langlois, R. Savan and M. Gale. Univ. of Univ., Natl. Hansen’s Dis. Program, Lab. Res. Washington and Univ. of Minnesota. (74.3) Branch, Louisiana State Univ. and State Key Lab. 3:15 Concomitant effector and LAG-3 regulatory responses of Agro-biotechnology, China Agricultural Univ. (73.2) of Th1-committed cells in acute influenza. A. Dutta, 3:00 Rainbow trout as a model for the study of neuroimmune C-T. Huang, C-Y. Hung, T-C. Chen, C-Y. Lin, interactions in the nasal mucosa. I. Salinas, Y-C. Lin, C-S. Chang, T-A. Chen and A. Sepahi, A. Kraus and P. Das. Univ. of New Y-L. Huang. Chang Gung Mem. Hosp., Taiwan. Mexico. (73.5) (74.4)

5 THURSDAY—PM

’ 3:30 BCL6 modulates tissue neutrophil survival and 14. AAI PRESIDENT S ADDRESS exacerbates pulmonary inflammation following President’s Program influenza infection. J. Sun and B. Zhu. Mayo Clin. — (74.5) THU. 5:00 PM BALLROOM 20BCD 3:45 Autoreactive potential of universal influenza vaccines. CHAIR: J.L. FLYNN M.A. McGargill, M.R. Pillai, T-C. Chang, J. Crawford, R. Keating, J. Labombarde, PRESENTATION OF THE AAI LIFETIME ACHIEVEMENT C. Lewis, J. Guthmiller, Q-Z. Li, P.C. Wilson and AWARD P. Thomas. St. Jude Children’s Res. Hosp., The Recipient: P.J. Fink. Univ. of Washington Univ. of Chicago and Univ. of Texas Southwestern Med. Ctr. (74.6) The AAI Lifetime Achievement Award recognizes a 4:00 Influenza A virus (IAV) infection in humans leads to deserving member for a career of scientific achievement and expansion of highly diverse CD8+ T cell repertoires for contributions to AAI and fellow immunologists. cross-reactive with Epstein Barr virus. A. Gil, R. Mishra, I.Y. Song, N. Aslan, D. Ghersi and PRESIDENT’S ADDRESS L.K. Selin. Univ. of Massachusetts Med. Sch. and Introduction: Olja Finn. Univ. of Pittsburgh Univ. of Nebraska. (74.7) 4:15 Mechanism of influenza virus-induced inflammatory cell 5:10 At the interface of microbiology and immunology. death. K. Sannula and T-D. Kanneganti. St. Jude J.L. Flynn. Univ. of Pittsburgh Sch. of Med., AAI Children’s Res. Hosp. (74.8) President.

15. OPENING NIGHT NETWORKING EVENT Social Event

THU. 6:00 PM—CENTER TERRACE Following the President’s Address, exit left to the Center Terrace for the Opening Night Networking Event. Connect with friends, make new acquaintances, and plan your week. Bring the complimentary drink ticket attached to your meeting badge.

6 FRIDAY—AM FRIDAY MORNING

MAY 10

16. MAJOR SYMPOSIUM A: INTERACTIONS OF 18. FROM THERE TO HERE, FROM HERE TO INNATE AND ADAPTIVE IMMUNE CELLS THAT THERE: INFLAMED THINGS PROMOTE AUTOIMMUNITY ARE EVERYWHERE Major Symposium Block Symposium F

FRI. 8:00 AM—BALLROOM 20D FRI. 8:00 AM—ROOM 26AB R I CHAIRS: D. HAFLER, M.A. BROWN CHAIRS: F.E. LUND, M. GERNER 8:00 Finding the culprit in human autoimmune disease. 8:00 Exit of human cutaneous resident memory CD4 T cells D.A. Hafler. Yale Univ. that enter the circulation and seed distant skin sites. 8:35 How testosterone shapes T cell responses in P.A. Morawski, M. Klicznik, B. Hoellbacher, neuroinflammatory disease. M.A. Brown. Feinberg S. Varkhande, S. Motley, T. Duhen, I. Gratz and Sch. of Med., Northwestern Univ. D.J. Campbell. Benaroya Res. Inst. and Univ. of 9:10 Blaming the victim: target tissues in the autoimmune Salzburg, Austria. (51.7) response. M.A. Su. Univ. of North Carolina, Chapel 8:15 Type1 IFN signaling on Tregs modulates the migration Hill. of myeloid derived suppressor cells. S. Tanwar, 9:45 T cell intrinsic and extrinsic factors determine the A. Metidji and E.M. Shevach. NIAID, NIH. (51.4) function of Tregs in autoimmunity. J. Buckner. 8:30 Germinal center organization mediated by T-bet- Benaroya Res. Inst. dependent expression of CXCR3 and CCR6. 10:20 Th17 functions in mouse and man. M. McGeachy. Univ. J.N. Peel, S.L. Stone, C.D. Scharer, J. Boss and of Pittsburgh. F.E. Lund. Univ. of Alabama, Birmingham and Emory 10:55 Th17 cells and induction of tissue inflammation. Univ. (51.1) V.K. Kuchroo. Brigham and Women’s Hosp. 8:45 Intranodal dendritic cell relocalization during inflammation impacts T cell immunity. J.M. Leal, 17. MAJOR SYMPOSIUM B: EXTRINSIC AND B. Olin and M.Y. Gerner. Univ. of Washington INTRINSIC IMMUNE ASPECTS OF THE Sch. of Med. (51.11) TUMOR MICROENVIRONMENT 9:00 Dendritic cell-induced dissemination of Mycobacterium tuberculosis into the central nervous system. Major Symposium T.E. Gilpin, F.R. Walter, M. Herbath, M. Sandor and Z. Fabry. Univ. of Wisconsin, Madison. (51.8) FRI. 8:00 AM—BALLROOM 20BC 9:15 Epithelial cell-derived chemokines induce DC CHAIRS: V.H. ENGELHARD, M.J. TURK recruitment to the gastric epithelium upon H. pylori 8:00 Immune cell infiltration and tertiary lymphoid structures infection. M. Hashimi, T.A. Seberll, B. Sidar, as determinants of antitumor immunity. J.N. Wilking and D. Bimczok. Montana State V.H. Engelhard. Univ. of Virginia. Univ. (51.6) 8:35 Tissue-resident memory T cell responses to cancer. 9:30 Monocyte activation in cardiovascular disease through fl M.J. Turk. Dartmouth Geisel Sch. of Med. in ammatory signaling associated with CD11c 9:10 The role of the microbiome in response and toxicity to function. A.A. Hernandez, G.A. Foster, Y. Dai, cancer therapy. J.A. Wargo. MD Anderson Cancer K.R. Rivara, K. Bailey, G.D. Singh and Ctr. S.I. Simon. Univ. of California, Davis. (51.13) 9:45 Visualization and class discovery of tumoral immune 9:45 Epithelial 2 regulates transepithelial fl systems – beyond checkpoint blockade. M. Krummel. migration of neutrophils into the in amed airspace. Univ. of California, San Francisco. W-C. Lin, K. Gowdy, J. Madenspacher, R. Zemans, 10:20 Metabolic regulation of anti-tumor immunity. K. Yamamoto, M. Lyons-Cohen, H. Nakano, S.M. Kaech. Salk Inst. K. Janardhan, C. Williams, D. Cook, J. Mizgerd 10:55 Protective spontaneous humoral responses in ovarian and M. Fessler. NIEHS, NIH, East Carolina Univ., cancer. J.R. Conejo-Garcia. H. Lee Moffitt Cancer Univ. of Michigan and Boston Univ. Sch. of Med. Ctr. and Res. Inst. (51.14)

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7 FRIDAY—AM

19. INNATE IMMUNE MECHANISMS 20. CELLULAR MECHANISMS OF INNATE Block Symposium IMMUNITY I Block Symposium FRI. 8:00 AM—ROOM 30AB FRI. 8:00 AM—ROOM 31ABC CHAIRS: N. SUBRAMANIAN, M. VIJAY-KUMAR HAIRS A. JAMIESON, C. BRYANT 8:00 Autophagy-based unconventional secretion of alarmin C : HMGB1 by keratinocytes plays a pivotal role in 8:00 Crosstalk between lung epithelial cells and myeloid cells psoriatic skin inflammation. Z. Wang, H. Zhou, in innate immune defense. X. Liu, M.A. Boyer and H. Zheng, X. Teng, X. Wei and J. Li. Sichuan S. Shin. Perelman Sch. of Med., Univ. of Univ., China. (59.1) Pennsylvania. (62.1) 8:15 Dietary soluble fiber induces HCC in dysbiotic mice 8:15 Type III interferons are expressed in tuberculosis through a spectrum of immunosuppressive granulomas and may influence signaling in mediators. M. Vijay-Kumar, B.S. Yeoh, V. Singh, epithelioid macrophages. P. Talukdar and R.M. Golonka and P. Saha. Univ. of Toledo Col. of J.T. Mattila. Univ. of Pittsburgh Grad. Sch. of Publ. Med. and Life Sci., The Pennsylvania State Univ. and Hlth. (62.2) The Univ. of Toledo Col. of Med. and Life Sci. (59.3) 8:30 Phenotypic analysis of alveolar macrophage 8:30 Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent populations in old mice and their response to inflammation. B.A. Croker, M. Speir, C.J. Nowell, Mycobacterium tuberculosis infection. W.P. Lafuse, A.A. Chen, J.A. O’Donnell, A.A. D’Cruz, M. Bliss- M.V.S. Rajaram, Q. Wu, J.I. Moliva, J.B. Torrelles, Moreau, S. Wang, M.A. Kelliher, R. Hakem and J. Turner and L.S. Schlesinger. Dept. of Microbial M. Gerlic. Boston Children’s Hosp., Monash Inst. of Infection and Immunity, The Ohio State Univ. and Pharmaceutical Sci., Australia, Harvard Med. Sch., Texas Biomed. Res. Inst. (62.3) The Walter and Eliza Hall Institute of Med. Res., 8:45 Alveolar macrophage responses to Mycobacterium Australia, Univ. of Massachusetts Med. Sch., Univ. tuberculosis reveal human-to-human variation in of Toronto, Canada and Tel Aviv Univ., Israel. (59.4) important immunobiology pathways gleaned from 8:45 WITHDRAWN functional genomics study. A. Azad, A. Papp, 9:00 Extracellular calcium-phosphate nanoparticles activate X. Zhou, M. Pietrzak, M. Wang, E. Arnett, the NLRP3 inflammasome through CaSR signaling. M. Montoya, S. Handelman, G. Rempala, S. Lin, E. Jager,¨ C. Staubert,¨ P. Sungur, S. Hoppener,¨ W. Sadee and L. Schlesinger. Texas Biomed. Res. S. Strobel, S. Murthy, M. Rossol and U. Wagner. Inst., The Ohio State Univ. and Univ. of Michigan. Leipzig Univ., Germany and Friedrich Schiller Univ. (62.4) Jena, Germany. (59.5) 9:00 Caspase 11 negatively regulates carbapenem-resistant 9:15 A sustained small increase in NOD1 expression Klebsiella Pneumoniae-induced pneumonia. promotes ligand-independent oncogenic activity. L. Ghimire, S. Paudel, L. Jin and S. Jeyaseelan. L. Rommereim, A.S. Akhade, B. Dutta, Louisiana State Univ. (62.5) C. Hutcheon, N. Lounsbury, C. Rostomily, 9:15 Novel role of zinc homeostasis in IL-23 regulation and R. Savan, I. Fraser, R. Germain and host defense following bacterial infection. S.C. Hall, N. Subramanian. Inst. for Systems Biol., NIAID, D.R. Smith, D.M. Katafiasz, K.L. Bailey and NIH and Univ. of Washington Sch. of Med. (59.6) DarenL. Knoell. Univ. of Nebraska Med. Ctr. (62.6) 9:30 A loss-of-function single nucleotide polymorphism in 9:30 Ketogenic diet activates protective gd T cell responses cytochrome b5 reductase 3 amplifies the response against influenza virus infection. E.L. Goldberg, of bone marrow-derived macrophages to high salt. R. Molony, S. Sidorov, E. Kudo, V.D. Dixit and J.A. Jerome, E.R. DeVallance, P.J. Pagano and A. Iwasaki. Yale Sch. of Med. (62.7) A.C. Straub. Univ. of Pittsburgh Sch. of Med. (59.7) 9:45 Gamma Herpesvirus manipulates HVEM regulated IL- 9:45 Exploiting altered enhancer landscapes to decode 1b pathway to evade immune responses. W.W. Lin, pathogenic changes in of diverse E. Chapell, G. Brar, T-T. Wu, R. Sun, B. Baaten and hepatic macrophages. T.D. Troutman, C.F. Ware. Sanford Burnham Prebys Med. Discovery J.S. Seidman, M. Sakai, A. Gola, Z. Ouyang, Inst. and Univ. of California, Los Angeles. (62.8) N.J. Spann, C.M. Bruni, H. Bennett, K. Ego, B-C. Vu, X. Sun, M. Pasillas, J.L. Witztum, 21. INNATE LYMPHOCYTE DEVELOPMENT, R.N. Germain and C.K. Glass. Univ. of California, STROMA, AND AGING San Diego and NIAID, NIH. (59.2) Block Symposium

FRI. 8:00 AM—ROOM 25ABC

CHAIRS: A. Beaulieu, M. Kronenberg 8:00 Single cell sequencing reveals mouse MAIT cell diversity. S. Chandra, G. Seumois, C. Ramirez, G. Seo, P. Vijayanand and M. Kronenberg.La Jolla Inst. for Allergy and Immunology. (65.1)

8 FRIDAY—AM

8:15 Dose-dependent requirements for ETS1 in invariant 8:45 Passive infusion of Fc-modified neutralizing antibodies natural killer T cell development. R.C. Morgan and does not affect the dynamics of plasma virus decay in B.L. Kee. Univ. of Chicago. (65.2) SHIV-infected macaques. M. Asokan, A. Maximova, 8:30 Assessment of the global chromatin landscape and J. Dias, A.R. Crowley, A. Pegu, D. Ambrozak, transcriptome of peripheral iNKT cell subsets. K. McKee, W. Shi, J-P. Todd, M.E. Ackerman, M.L. Paynich, I. Engel, G. Seumois, S. Liang, L. Gama, B.F. Keele, J.D. Lifson, A.S. Perelson, S. Herrera de la Mata, A. Sethi, A. Logandha J.R. Mascola and R. Koup. NIAID, NIH, Geisel Sch. Ramamoorthy Premlal, J.A. Greenbaum, of Med., Dartmouth Col., Frederick Natl. Lab. and Los P. Vijayanand, A. Rao, J. Scott-Browne and Alamos Natl. Lab. (72.6) M. Kronenberg. La Jolla Inst. for Immunology and 9:00 Impact of gut microbiota on vaccine response in HIV Natl. Jewish Hlth. (65.3) exposed infants. D.D. Nyangahu, C. Plumlee, 8:45 Single cell profiling reveals unique stages of NK cell J. Wendoh, K.B. Urdahl and H. Jaspan. Seattle F ’ development. A.M. Beaulieu. Rutgers New Jersey Children s Res. Inst., Univ. of Cape Town, South R Med. Sch. (65.4) Africa and Univ. of Washington. (72.10) 9:00 Predicting natural killer cell behavior with mathematical 9:15 Higher PIK3C2B gene expression of H1N1+ specificB I models. A.J. Millan, S. Sindi and J. Manilay. Univ. of cells is associated with lower H1N1 immunogenicity California, Merced. (65.5) after trivalent influenza vaccination in perinatally HIV 9:15 Heterogeneity in differentiation capacity among ILC infected children. N. Cotugno, S. Zicari, precursors in human peripheral blood and tissues. E. Morrocchi, L.R. De Armas, S. Pallikkuth, E. Kokkinou, I. Gutierrez-Perez, R. Vinay Pandey, S. Rinaldi, S. Rocca, E.C. Manno, P. Zangari, A. Rao, L. Mazzurana, S. Almer, C. Ho¨ og,¨ S.F. Andrews, A. Cagigi, P. Rossi, U. Lindforss, Y. Bryceson and J. Mjosberg¨ . Ctr. A.B. McDermott, S. Pahwa and P. Palma. for Infectious Med., Karolinska Inst., Sweden, Children’s Hosp., Italy, Univ. of Rome, Tor Vergata, Karolinska Inst., Sweden, Karolinska Inst., Italy, Univ. of Miami and VRC, NIAID, NIH. (72.11) Stockholm, Solna, Karolinska Inst., and IBD- 9:45 Recombinant human IL-15 in combination with anti-PD- Center, Gastroenterology, Karolinska Univ. Hosp., (Avelumab) in SIV infected rhesus macaques Sweden, Karolinska Inst., Sweden. and Karolinska leads to the expansion of a subset of CXCR3+PD1-/ Univ. Hospital, Sweden. (65.6) low CD8 T cells. M. Moussa, J. Cheng, P. Chen, 9:30 Sustained E protein activity selectively inhibits ILC2 H. Chen, T. Li, J. Qin, J.D. Lifson, M.C. Sneller, development. H.R. Berrett and J. Alberola-Ila. L. Krymskaya, S. Godin, C. Lane and Oklahoma Med. Res. Fndn. (65.7) M. Catalfamo. Georgetown Univ. Sch. of Med., 9:45 Interleukin-37 improves aging-associated declines in NIH, NIAID, NIH, Leidos Biomed. Res., Inc. and adaptive immunity leading to enhanced Smithers Avanza Toxicology Services. (72.13) suppression of Ph+ leukemia. C.J. Henry, E. Eisenmesser, C.A. Dinarello and 23. HOW TO CONVERT YOUR CV INTO A RESUM´ E´ J. DeGregori. Emory Univ. Sch. of Med. and Univ. of Colorado Anschutz Med. Campus. (65.8) Career Development Session FRI. 9:00 AM—ROOM 32AB 22. HIV/SIV VACCINE/IMMUNOTHERAPY AND CHAIR: M.T. LITZINGER IMPACT OF HIV/SIV INFECTION IN ANTIGEN-SPECIFIC IMMUNITY For anyone seeking a job outside of academe, how you present yourself on paper is critical. A well-prepared resum´ e´ Block Symposium can make all the difference in securing that interview. The focus FRI. 8:00 AM—ROOM 33ABC of this session will be on the important elements of a resum´ e,´ the differences between a resum´ e´ and the standard academic CHAIRS: E. JANOFF, M. CATALFAMO curriculum vitae, and the information needed to make a good 8:00 Influence of vaccine-induced mucosal NKp44+ and impression. In this special career development session, mucosal NKp44-NKG2A- cells on SIV-infection attendees will be instructed in how to transform their CVs into outcomes in rhesus macaques. M.A. Rahman, professional resum´ es.´ Small breakout sessions for individual E. Ko, G. Enyindah-Asonye, S.H. Hait, T. Hoang consulting will follow from 10:30 AM to 12:30 PM in Room and M. Robert-Guroff. NCI, NIH. (72.5) 28A. Bring your CV! 8:15 A replicating adenovirus-SIV recombinant prime/protein 9:00 Introduction. M.T. Litzinger. American Assn. of fi boost regimen induces SIV-speci c T and B cell Immunologists. responses in lymph nodes associated with humoral 9:05 How to convert your CV into a resum´ e.´ D. Haseltine. immunity in the genital mucosa of female rhesus Baylor Col. of Med. macaques. S.H. Hait, C.J. Hogge, Z. Mushtaq, T. Hoang and M. Robert-Guroff. NCI, NIH. (72.3) 8:30 Novel HIV DNA vaccine changes the immune hierarchy and elicits broad cytotoxic T cell responses targeting Resum´ e?´ Visit the AAI Jobs Board in the Exhibit Hall, subdominant viral epitopes. B.K. Felber, Z. Lu, Friday – Sunday, 9:30 AM – 4:30 PM. X. Hu, A. Valentin, M. Rosati, J.I. Mullins and G.N. Pavlakis. Natl. Cancer Inst. and Univ. of Washington. (72.4)

9 FRIDAY—AM

24. ADVOCATING FOR BIOMEDICAL RESEARCH: 26. THE INTERNATIONAL SOCIETY OF WE’VE DONE IT AND SO CAN YOU! COMPARATIVE AND DEVELOPMENTAL Committee-Sponsored Session IMMUNOLOGY (ISDCI) SYMPOSIUM: DEUTEROSTOME IMMUNE INNOVATIONS Sponsored by the AAI Committee on Public Affairs FROM ECHINODERMS TO MAMMALS — FRI. 10:15 AM ROOM 26AB Guest Society Symposium

CHAIR: D.D. CHAPLIN FRI. 10:15 AM—ROOM 30AB

A 2017 report by the Congressional Management CHAIRS: M. CRISCITIELLO, T. DE TOMASO Foundation supports what we at AAI have long believed: that advocacy is important and effective, and that direct interactions 10:15 Evolution of leukocytes transcriptional development in between constituents and lawmakers/their staffs are especially the sea urchin. C. Schrankel. Univ. of California, San influential. Consistent, strong advocacy has played an essential Diego. role in persuading Congress to increase the NIH budget by $9 10:45 Primordial histocompatibility in a colonial tunicate. T. de billion over the last four years and to reject a harmful provision Tomaso. Univ. of California, Santa Barbara. that could have significantly increased taxes on graduate 11:15 Lamprey variable lymphocytes receptors. J. Rast. students. But how can you, as a working scientist, help ensure Emory Univ. that supporting biomedical research, NIH, and the needs of 11:45 Cattlebodies expand paratope possibilities. V. Smider. researchers remain top Congressional priorities? Scripps Res. Inst. This session will explore key questions like why, how, and when you should advocate for biomedical research. It will also 27. REGULATION OF INNATE AND CYTOTOXIC feature a panel of immunologists from various career stages who LYMPHOCYTE RESPONSES: have engaged in advocacy in a variety of interesting and unique MOLECULAR MECHANISMS ways. These researchers will share their experiences and then welcome questions from the audience. Block Symposium — PANELISTS: FRI. 10:15 AM ROOM 31ABC • W.M. Yokoyama. Washington Univ. Sch. of Med. in CHAIRS: J. SUN, N. LA GRUTA St. Louis. • P.J. Fink. Univ. of Washington. 10:15 PD-1 is negatively regulated by LSD1 through • L.A. Borghesi. Univ. of Pittsburgh interactions with Blimp-1 during acute viral infection. D.K. Neeld, A. Bally, P. Lu, • J.P. Gigley. Univ. of Wyoming • M. Guerra-Maupome. Iowa State Univ. Col. of Vet. P. Majumder, B. Barwick and J.M. Boss. Emory Med. Univ. Sch. of Med. (60.13) 10:30 BHLHE40 programs mitochondrial regulation of resident CD8+ T cell fitness and functionality. C. Li, 25. SOCIETY FOR MUCOSAL IMMUNOLOGY (SMI) B. Zhu, Y. Son, Z. Wang, B.T. Edelson, T. Hitosugi, SYMPOSIUM: COMBATING PATHOGENS AT J.C. Rathmell, H. Dong and J. Sun. Mayo Clin., MUCOSAL SURFACES Washington Univ., St. Louis and Vanderbilt Univ. Guest Society Symposium Med. Ctr. (60.2) 10:45 Identification of T subsets with distinct cellular states — RM FRI. 10:15 AM ROOM 25ABC and memory potential. K. Omilusik, JJ. Milner, CHAIRS: L.A. ZENEWICZ, J. LUND N. Kurd, C. Toma, J.T. Chang and A.W. Goldrath. Univ. of California, San Diego. 10:15 Protecting the lung despite the costs through innate (60.14) immune triage mechanisms. A. Jamieson. Brown 11:00 Tracking the in vivo history and fate of IL-2 producing Univ. CD8+ T cells during memory differentiation. 10:45 The rise and fall of lung-resident T cell memory. Y. Yuzefpolskiy, S. Sarkar and V. Kalia. Univ. of J. Kohlmeier. Emory Univ. Washington Sch. of Med. (60.15) 11:15 Development of mucosal resident memory T cells. 11:15 Trib1 controls antiviral immunity by restraining CD4+ D. Farber. Columbia Univ. and CD8+ T cell effector responses during chronic 11:45 Regulation of immunity to virus infection in the genital infection. K.S. Rome and W.S. Pear. Univ. of tract. J. Lund. Fred Hutchinson Cancer Res. Ctr. Pennsylvania. (60.16) 11:30 Dynamic changes in 3D spatial chromatin organization underpin virus-specific killer T cell differentiation. S.J. Turner, A. Morey, M. Olshansky, P. Collas, Z. He, C. Murre and B.E. Russ. Monash Univ., No photography of any Australia, Univ. of Oslo, Norway and Univ. of sort is allowed in lectures California, San Diego. (60.11) or poster sessions.

10 FRIDAY—AM

11:45 High spare respiratory capacity is a canonical feature of 12:00 Inhibiting EZH2 function prevents and treats chronic virtual memory, but not conventional memory CD8 graft vs host disease by disrupting germinal center T cells, and is driven by IL-15 signaling. N.L. La formation and plasma cell maturation. M.C. Zaiken, Gruta, K.M. Quinn, F. Kraus, L. Formosa, R. Flynn, K. Paz, S. Rhee, P. Park, M. Hemming, M. Dagley, E. Saunders, T. Hussain, L. Assmus, P. Sage, A. Sharpe, L. Luznik, I. Mailard, G.R. Hill, A. Costin, J. Clark, G. Ramm, K. Good-Jacobson, K. MacDonald, J. Serody, C. Cutler, J. Koreth, M. McConville and M. Ryan. Monash Univ., D. Miklos, J. Antin, R. Soiffer, J. Ritz, Australia and Univ. of Melbourne, Australia. (60.7) J. Bradner, J. Qi and B.R. Blazar. Univ. of 12:00 Single cell transcriptomics resolves activation dynamics Minnesota, Dana Farber Cancer Inst., Harvard and cellular states of human blood and tissue T cells. Med. Sch., Brigham and Women’s Hosp., Harvard P.A. Szabo, H.M. Levitin, M. Miron, M.E. Snyder, Med. Sch., Harvard Med. Sch., Johns Hopkins Univ. T. Senda, J. Yuan, Y.L. Chen, E.C. Bush, P. Dogra, Sch. of Med., Univ. of Pennsylvania, Fred Hutchinson F P. Thapa, P.A. Sims and D.L. Farber. Columbia Cancer Res. Ctr., QIMR Berghofer Med. Res. Inst., R Univ. Med. Ctr. (60.5) Lineberger Comprehensive Cancer Ctr., Univ. of North Carolina, Chapel Hill and Stanford Univ. Sch. I 28. HEMATOPOIETIC STEM CELL of Med. (69.42) TRANSPLANTATION: ALL OF IMMUNOLOGY OCCURRING IN ONE MODEL 29. VIRUSES, CD8+ T CELLS, AND NATURAL KILLERS Block Symposium Block Symposium FRI. 10:15 AM—ROOM 30CDE FRI. 10:15 AM—ROOM 33ABC CHAIRS: B. BLAZAR, C. CAPITINI CHAIRS: S. WAGGONER, A. JOHNSON 10:15 Modeling graft-vs-host disease in humanized mice using different hematopoietic stem cells sources 10:15 Regulation of antiviral CD8+ T cell immunity by CD352/ reveals inherent differences in Tc and myeloid cell SLAMF6: from patterns to pathways. V. van der biology. N.J. Hess, P. Hematti and J.E. Gumperz. Heide and D. Homann. Icahn Sch. of Med. at Univ. of Wisconsin, Madison. (69.2) Mount Sinai. (76.1) 10:45 Neutralization of IL-2 prevents acute GVHD while 10:30 Activation of microglia in CD8 T cell-initiated blood-brain preserving GVL activity via regulating PD-L1/PD-1 barrier disruption induced during Theiler’s virus signaling. Q. Song, X. Wang, P.J. Martin, Y. Chen infection. R. Khadka, J. Zheng, K. Ayasoufi, and D. Zeng. Beckman Res. Inst., City of Hope, Fred F. Jin, Z. Trtiz, L. Wu and A. Johnson. Mayo Hutchinson Cancer Res. Ctr. and Fujian Med. Univ. Clin. Grad. Sch. of Biomed. Sci. and Mayo Clin., Union Hosp., China. (69.11) Grad. Sch. of Biomed. Sci. (76.2) 11:00 High stearic acid diet aggravates aGVHD by promoting 10:45 Cytomegalovirus infection drives avidity selection of Th17 cells through Akkermansia muciniphila. S. Ma, natural killer cells. N.M. Adams, D. Lumaquin, B. Yang, H. Gong, X. Wu and D. Wu. Soochow E.K. Santosa, B.M. Whitlock, B.T. Jackson, Univ., China. (69.24) J.B. Le Luduec, R. Sottile, O.E. Weizman, 11:15 Expression of the butyrate/niacin receptor, GPR109a M. Huse, K.C. Hsu and J.C. Sun. Mem. Sloan on T cells plays an important role in a mouse model of Kettering Cancer Ctr. (76.3) graft versus host disease. M.D. Docampo, C. Stein- 11:00 The Ly49G2 inhibitory receptor is essential to MHC I- Thoeringer, A. Lazrak, M. Burgos da Silva and dependent NK cell control of murine cytomegalovirus M.R.M. van den Brink. Mem. Sloan Kettering Cancer infection. J.Michael Cronk, A. Gamache, Ctr. (69.34) A. Gillespie and M.G. Brown. Univ. of Virginia. 11:30 Immune responses to the microbiome tune MHC class II (76.5) antigen presentation by the intestinal epithelium to 11:15 Single cell cloning of untreated HIV-specific natural control gut pathology. M. Koyama, killer cells in humans. O.A. Lucar, J. Ghofrani, P. Mukhopadhyay, I.S. Schuster, A.S. Henden, P.A. Goepfert, S. Jost and R.K. Reeves. Harvard J. Hulsd¨ unker,¨ A. Varelias, M. Vetizou, Med. Sch. and Univ. of Alabama, Birmingham. (76.4) R.D. Kuns, R.J. Robb, P. Zhang, B.R. Blazar, 11:30 Accumulation of CXCR5+ NK cells during chronic SHIV R. Thomas, J. Begun, N. Waddell, G. Trinchieri, infection is associated with enhanced viral control. R. Zeiser, A.D. Clouston, M.A. Degli-Esposti and V. Velu, S.A. Rahman, J.M. Billingsley, G.R. Hill. Fred Hutchinson Cancer Res. Ctr., QIMR C.C. Ibegbu, A. Shiferaw, F.J. Villinger, Berghofer Med. Res. Inst., Monash Univ., Australia, S. Bosinger, P. Johnson, R.R. Amara and Freiburg Univ. Med. Ctr., NCI, NIH, Univ. of V. Velu. Emory Univ., Univ. of Louisiana Lafayette Minnesota, Sch. of Med., Univ. of Queensland, and Yerkes Primate Res. Ctr. and Emory Vaccine Ctr. Australia and Envoi Pathology. (69.38) (76.6) 11:45 Human monocytes educated with exosomes from TLR4 11:45 LAG-3 modulation of natural killer cell primed mesenchymal stem cells treat acute radiation immunoregulatory function. A. Ali, M.T. Moran, syndrome by promoting hematopoietic recovery. J. Tuazon, I. Gyurova, D.A.A. Vignali and M.H. Forsberg, J. Kink, P. Hematti and S.N. Waggoner. Cincinnati Children’s Hosp. Med. C.M. Capitini. Univ. of Wisconsin, Madison. (69.39) Ctr., Univ. of Cincinnati and Univ. of Pittsburgh Sch. of Med. (76.7)

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12:00 IL-18 defines exclusive “memory-like” NK cell • N. Pullen. Univ. of Northern Colorado, Authentic populations. R.R. Anderko, C.R. Rinaldo and science engagement: toward a CURE for R.B. Mailliard. Univ. of Pittsburgh Grad. Sch. of undergraduate immunology. Publ. Hlth. (76.8) • K. Lukin. Univ. of Colorado, Denver. J. Novack. Col. of Med., Pacific Northwest Univ. S. Redmond. 30. IMMUNOLOGY TEACHING INTEREST GROUP Radford Univ. Using case studies across the immunology curriculum. Career Development Session Sponsored by the AAI Education Committee 31. CAREERS ROUNDTABLE AND SPEED NETWORKING SESSION FRI. 11:00 AM—ROOM 32AB Career Development Session CHAIRS: A.K. BAMEZAI, S. JAMES Sponsored by the AAI Minority Affairs Committee (MAC) Are you looking for new ideas or strategies to enliven and improve your teaching? If so, please join us for this special FRI. 11:45 AM—BALLROOM 20A interest group which will focus on strategies that instructors HAIR R.J. BINDER can use to successfully convey immunology concepts to C : students at the undergraduate and graduate level. The Registration Fee: $30 (includes lunch plus coffee during session will explore the use of course-based undergraduate networking hour). Networking skills have never been more research experiences (CURE), just in time teaching (JiTT), crucial to ensure success for early/mid-career scientists, research articles, entrepreneurial mindset activities, and more including those traditionally under-represented in biomedical through talks and structured breakout discussion groups. Current research. At the roundtable, take advantage of the opportunity educators, new faculty, and trainees with an interest in teaching to meet in small-group format with accomplished, senior are welcome. immunologists to hear how they have handled the career PANELISTS: challenges you now face and learn what they believe will work 11:03 M. Snyder. Towson Univ., Student outcomes in a for you today. Then, practice networking in a relaxed environment CURE course using simple model organisms to offering a structured networking exercise and personalized fi characterize host-pathogen interactions. feedback on communicating your scienti c interests/objectives most effectively. Scientists and trainees of all backgrounds are 11:17 L. Shornick. Saint Louis Univ., Using an entrepreneurial mindset activity to create value in encouraged to attend! an immunobiology course. Discussion Topics: 11:31 J. Frelinger. Univ. of Rochester, Immunology “hooks”: • Grad Student: finding a mentor, setting sights on strategies to increase student engagement. postdoc training 11:45 W. Carr. Medgar Evers Col., City Univ. of New York, • Postdoc: finding a mentor, setting sights on a faculty Using “Pillars of Immunology” research articles position to enhance problem-solving skills among • Junior Faculty: preparing for promotion and tenure undergraduate students at a Predominantly Black • Work-life Balance, it’s real! Institution. • Academia or Industry: how to decide (or switch sides) • BREAKOUT SESSION LEADERS: Government Agency Careers • Non-Bench-ResearchScienceCareers–entrepreneurship/ • D. Brown. Univ. of Nebraska, Lincoln, JiTT strategies fi and student outcomes. research technology; non-pro ts/foundations; intellectual • D. Chatterjea. Macalester Col., Ready to talk about it? property/patent law A toolkit for reading and discussing scientific papers in undergraduate immunology classrooms.

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MAY 10

32. TOWARDS ONE HEALTH: UNDERSTANDING 34. THE AMERICAN SOCIETY OF TROPICAL DISEASE WITH ANIMAL MODELS MEDICINE AND HYGIENE (ASTMH) Committee-Sponsored Session SYMPOSIUM: IMMUNE RESPONSES TO PARASITES Sponsored by the AAI Veterinary Immunology Committee F Guest Society Symposium R FRI. 12:30 PM—BALLROOM 26AB FRI. 12:30 PM—ROOM 25ABC I CHAIRS: C. LOVING, A.J. YOUNG CHAIRS: R. STEPHENS, F.M. NDUNGU One Health is an approach to ensure the well-being of people, animals, and the environment through collaborative 12:30 ab and gd T cells and cytokines in the regulation of the problem solving and interdisciplinary collaboration. Many of the immune response to P. falciparum malaria. microbes and environmental stressors that impact humans also M.E. Feeny. Univ. of California, San Francisco impact animals, as they overlap in many of the same ecosystems. Med. Ctr. The intent of this symposium is to present research in animal 1:00 LINGO : a new language for the mucosal models that provide important discoveries and findings for barrier. D. Herbert. Univ. of Pennsylvania Sch. of improving both human and animal health. The symposium will Vet. Med. feature research in pigs, neonatal cattle, and fish and will span 1:30 From mouse to man to vaccine: B cell memory to topics of stress, interventions, therapy, and neuroimmune malaria. F.M. Ndungu. KEMRI-Wellcome Trust interactions. It will showcase commonalities between human Res. Programme, Kenya. fi and animal health, and highlight the value of One Health 2:00 Ex vivo analysis of P. falciparum-speci c B cell approach for understanding immunity and enhancing disease responses to natural malaria infection in children resilience. and adults. C.S. Hopp. NIH, NIAID.

12:30 The pig as a translational model to evaluate NKT cell 35. CYTOKINES REGULATING INFLAMMATION therapy. J.P. Driver. Univ. of Florida. 1:00 Use of the neonatal calf for development of novel Block Symposium intervention strategies to reduce and prevent FRI. 12:30 PM—ROOM 30CDE respiratory syncytial virus infection. J.L. McGill. Iowa State Univ. CHAIRS: L.E. HARRINGTON, P. KUMAR 1:30 Early life stress impacts lifelong immune function, but 12:30 Mass-cytometry reveals global immune remodeling with how? Studying piglets may shed . A.J. Moeser. multi-lineage hypersensitivity to type I interferon in Michigan State Univ. Down syndrome. K.A. Waugh, A. Pandey, 2:00 Rainbow trout as model for understanding K.R. Jordan, K.P. Smith, R.E. Granrath, neuroimmune interactions at the nasal mucosa. S. Khanal, E.T. Butcher, A.L. Rachubinski, I. Salinas. Univ. of New Mexico. J.A. McWilliams, P. Araya, R. Minter, T. Dimasi, K.L. Colvin, D. Baturin, A.T. Pham, M.D. Galbraith, 33. THE AMERICAN SOCIETY OF M.E. Yeager, K.D. Sullivan, C.C. Porter, E.W. Hsieh TRANSPLANTATION (AST) SYMPOSIUM: and J.M. Espinosa. Linda Crnic Inst. for Down TEACHING OLD DOGMAS NEW TRICKS: Syndrome, Univ. of Colorado Anschutz Med. NOVEL FUNCTIONS OF MACROPHAGES AND Campus and Emory Univ. Sch. of Med. (52.1) DENDRITIC CELLS 12:45 A circulating NAD biosynthetic enzyme is a novel modulator of inflammation. A. Manago’, Guest Society Symposium V. Audrito, F. Mazzola, L. Sorci, F. Gaudino, FRI. 12:30 PM—ROOM 33ABC K. Gizzi, D. Incarnato, G. Minazzato, A. Iannillo, A. Varriale, S. D’Auria, G. Mengozzi, G. Politano, CHAIRS: D. ROTHSTEIN, A. CHONG S. Olivero, N. Raffaelli and S. Deaglio. Univ. of 12:30 Innate allorecognition drives allograft rejection. Turin, Italy, Polytechnic Univ. of Marche, Italy, F. Lakkis. Univ. of Pittsburgh. Italian Institute for Genomic Med., Italy, AOU Citta` 1:00 Donor pulmonary monocytes and allograft dysfunction. della Salute e della Scienza, Italy, Institute of Food A. Bharat. Northwestern Univ. Science, CNR, Italy and Politecnico di Torino, Italy. 1:30 Donor alveolar macrophages mediate chronic lung (52.2) allograft rejection. T. Monhanakumar. Univ. of Arizona. 2:00 Tolerogenic macrophages in the spleen and heart. X. Luo. Duke Univ.

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1:00 Human interleukin-2 receptor beta mutations 1:15 Inflammasome-mediated sensing of multi-component associated with defects in immunity and peripheral pore-forming toxins. S.M. Man. Australian Natl. tolerance. Z. Zhang, F. Gothe, P. Pennamen, Univ., Australia. (63.10) J. James, D. McDonald, C. Mata, Y. Modis, 1:30 Lysophosphatidylcholine activates caspase-1 by A. Alazami, M. Acres, W. Haller, C. Bowen, bringing about release of ATP and sensitization of R. Doffinger, J. Sinclair, S. Brothers, Y. Zhang, purinergic receptor. S. Ismaeel and A. Qadri. Natl. H. Matthews, S. Naudion, F. Pelluard, H. Alajlan, Inst. of Immunology, India. (63.5) Y. Yamazaki, L. Notarangelo, J. Thaventhiran, 1:45 Proteomic profiling of autoinflammatory diseases, K. Engelhardt, H. Al-Mousa, S. Hambleton, NOMID and CANDLE before and after treatment C. Rooryck, K.G.C. Smith and M.J. Lenardo. with interleukin-1 or with interferon blockade. NIAID, NIH, Univ. of Newcastle, UK, Univ. of S. Alehashemi, M. Sawhney, B. Sellers, A. de Cambridge, UK, King Faisal Specialist Hosp. and Jesus, F. Cheung, A. Biancotto and Res. Ctr., Saudi Arabia, Birmingham Children’s R. Goldbach-Mansky. NIAID, NIH. (63.4) Hosp., Starship Children’s Hosp., Univ. of 2:00 A host cell-intrinsic innate regulatory circuit limits Bordeaux, France and CHU Bordeaux, France. inflammasome activity and promotes immune (52.14) escape of Salmonella inside macrophages. 1:15 WITHDRAWN A.S. Akhade, S.M. Atif, B.S. Lakshmi, N. Dikshit, 1:30 A non-depleting PC61 antibody allows residual CD25 A. Qadri and N. Subramanian. Inst. for Syst. Biol. function that maintains regulatory T cell-mediated and Natl. Inst. of Immunology, India. (63.13) immune homeostasis. E. Hayes, C. Hagan and 2:15 Alarmin(g) outcomes of intracellular LPS sensing. D.J. Campbell. Benaroya Res. Inst. and Univ. of V. Rathinam, A. Russo, A. Menoret, Washington. (52.16) G. Rabinovich, S. Duduskar, S. Deshmukh and 1:45 A critical role for IL-37 in regulatory T cell maintenance A.T. Vella. UConn Hlth., Universidad de Buenos and CD4+ T cell inhibition. D.G. Osborne, Aires, Argentina and Jena Univ. Hosp. (63.14) J. Domenico, C.A. Dinarello and M. Fujita. Univ. of Colorado Sch. of Med. (52.17) 37. CELLULAR THERAPIES FOR CANCER 2:00 Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic Block Symposium T cells exhaustion. J. Li, X. Teng, X. Wei, FRI. 12:30 PM—BALLROOM 20D Z. Wang, F.L. Zeng, H. Zhou and H. Zheng. West China Hosp., Sichuan Univ., and Collaborative CHAIRS: M. MARTINEZ-PANIAGUA, R. KEDL Innovation Ctr. for Biotherapy, China. (52.10) 12:30 Identifying and engineering TCR specificity against 2:15 Human IL10 promoter haplotypes confer differential solid tumor neoantigens. M.S. Naradikian, outcomes to experimental colitis in humanized BAC L. Montero, S. Hall, R. Thota, A. Frentzen, mice. V. Vacharathit, J. Ma, D.C. Gunasekera, M. Bahmanof, L. Sternberg, J. Lane, P. Shah, A. Sheh, C.F. Brayton, M.T. Whary, Z. Kosaloglu-Yalcin, M. Lanka, A. Miller, J.G. Fox and J.H. Bream. Johns Hopkins Univ. B. Peters, E. Cohen and S. Schoenberger.La Sch. of Med., Johns Hopkins Univ. Bloomberg Sch. Jolla Inst. for Allergy and Immunology and Univ. of of Publ. Hlth. and Massachusetts Inst. of Technol. California, San Diego. (134.1) (52.13) 12:45 CAR+ T cell anti-tumor efficacy revealed by multi- dimensional single-cell profiling. X. An, G. Romain, 36. CYTOPLASMIC SENSING M. Martinez-Paniagua, I.N. Bandey, J.RT. Adolacion, M. Fathi, I. Liadi, F. Sadeghi, Block Symposium A. Mahendra, A. Amritkar, B. Roysam, H. Singh, FRI. 12:30 PM—ROOM 31ABC L.J. Cooper and N. Varadarajan. Univ. of Houston, Univ. of Texas MD Anderson Cancer Ctr. and CHAIRS: T.S. XIAO, S.M. MAN Ziopharm Oncology. (134.2) 12:30 Molecular mechanisms of gasdermin D autoinhibition 1:00 Disruption of TOX transcription factors enhances CAR and recognition by inflammatory caspases. T.S. Xiao, T cells function in solid tumors. H. Seo, J. Chen, Z. Liu, J. Yang, C. Wang and R. Yang. Case E. Gonzalez Avalos, D. Samaniego Castruita, Western Reserve Univ. (63.9) I. Lopez Moyado, C-J. Wu, A. Das, L-F. Lu, 12:45 Calpain drives pyroptotic vimentin cleavage, A. Bhandoola and A. Rao. La Jolla Inst. for intermediate filament loss, and cell rupture that Immunology, Univ. of California, San Diego and mediates immunostimulation. M.A. Davis, NCI, NIH. (134.3) M.R. Fairgrieve, A. den Hartigh, O. Yakovenko, 1:15 CD28 homolog is a strong activator of natural killer cells B. Duvvuri, C. Lood, S. Fink, W.E. Thomas and for lysis of B7H7-positive tumor cells. X. Zhuang and M.J. Gale. Univ. of Washington. (63.12) E.O. Long. NIAID, NIH. (134.5) 1:00 PtdIns4P on dispersed trans-Golgi network mediates 1:30 Intratumoral localization of pattern recognition receptor NLRP3 inflammasome activation. J. Chen and signaling informs CAR T cell design. L. Johnson, Z.J. Chen. Univ. of Texas Southwestern Med. Ctr. C.H. June and A.J. Minn. Univ. of Pennsylvania. (63.8) (134.4)

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1:45 Robust antitumor effects of SNA-based T cell therapy. Lustgarten-Thermo Fisher Scientific Award D. Dominguez, N. Chernyak, M. guan, Y. Chou, To advance the career of a mid-career scientist who attends the A. Long, L. Qin, L. Cole, J. Ann, S. Chen, J. Fan, AAI annual meeting and presents an outstanding abstract A. Lee, C. Mirkin and B. Zhang. Northwestern Univ. specifically in the area of immune regulation (134.7) Introduction: M.M. Hogan. AAI; and C. Hergersberg. Thermo 2:00 Integrated profiling of T cells and tumor cells Fisher Scientific. demonstrates metabolic adaptation essential for Recipient: M. Vijay-Kumar. Univ. of Toledo Col. of Med. and Life melanoma cell therapy. M.A. Martinez-Paniagua, Sci. C. Haymaker, J.R.T. Adolacion, X. An, I.N. Bandey, C. Creasy, T. Geiger, M. Harel, Pfizer-Showell Travel Award J. Robinson, J.B. Nielsen, A. Amritkar, To recognize the professional promise of an early-career S. Woodman, B. Roysam, P. Hwu, investigator F C. Bernatchez and N. Varadarajan. Univ. of Introduction: M.M. Hogan. AAI R Houston, Univ. of Texas MD Anderson Cancer Ctr., Recipient: S.M. Man. Australian Natl. Univ. Tel Aviv Univ., Isreal and Chalmers Univ. of Technol., I Sweden. (134.6) AAI-Thermo Fisher Trainee Achievement Awards To recognize promising trainees in the field of immunology. 38. AAI BUSINESS MEETING AND Introduction: M.M. Hogan. AAI; and C. Hergersberg. Thermo AWARDS PRESENTATIONS Fisher Scientific. AAI Session Recipients: FRI. 1:00 PM—ROOM 30AB B. Akkaya. NIAID, NIH. L. Beura. Univ. of Minnesota. CHAIR: M.M. HOGAN M. Deng. Univ. of North Carolina, Chapel Hill. AAI reports on the “state of the association” to its members at R. Haines. Emory Univ. every AAI annual meeting. Members will hear from the Executive S.L. Park. Univ. of Melbourne, Australia. Director, the Secretary-Treasurer, the Editors-in-Chief of AAI D.J. Theisen. Washington Univ. in St Louis. journals (The Journal of Immunology and ImmunoHorizons), OTHER AWARDS AND GRANTS BEING ACKNOWLEDGED and the Chair of the Committee on Public Affairs on the • AAI Early Career Faculty Travel Grants fi nancial standing of AAI, recent activities and initiatives, and • AAI Laboratory Travel Grants other matters of importance to the membership. Selected 2019 • AAI Undergraduate Faculty Travel Grants AAI awards will also be presented during this session. • AAI Trainee Abstract Awards Refreshments will be provided. • AAI Trainee Poster Awards AAI Distinguished Service Awards • FASEB Dream Travel Awards • AAI Minority Scientist Travel Awards Introduction: M.M. Hogan. AAI Recipients: 39. OBTAINING DEEP MECHANISTIC INSIGHTS B.A. Garvy. Univ. of Kentucky Chandler Med. Ctr. FROM AND INTO THE HUMAN SYSTEM For outstanding service to AAI and the immunology community as member and Chair of the AAI Committee on Public Affairs, Committee-Sponsored Session 2011-2018 Sponsored by the AAI Clinical Immunology Committee C.B. Mathias. Western New England Univ. FRI. 3:45 PM—ROOM 33ABC For outstanding service to AAI and the immunology community as Director of the AAI High School Teachers Program, 2012-2018 CHAIRS: J.S. ORANGE, V. TANEJA Chambers-Thermo Fisher Scientific Award The study of human disease has always provided the To advance the career of an early-career scientist who attends opportunity to derive unconventional insights into immunology. the AAI annual meeting and presents an outstanding abstract Current genomic technologies and cutting-edge biological specifically in the area of cancer biology approaches have not only made these opportunities more accessible, but they are being brought to bear with greater Introduction: M.M. Hogan. AAI; and C. Hergersberg. Thermo frequency and impact. Aberrant human immunity owing to Fisher Scientific. inherent genetic influence can result in immunodeficiency, Recipient: C. Lu. Med. Col. of Georgia, Augusta Univ. immunodysregulation, autoimmunity, autoinflammation or Lefrançois-BioLegend Award blends of these clinical expressions. The faculty of this To advance the career of a trainee who attends the AAI annual session have made seminal contributions to understanding meeting and presents an outstanding abstract specifically in the how aberrant immunity causes clinical disease while providing area of mucosal immunology profound mechanistic insights into how the human immune system works. Introduction: M.M. Hogan. AAI; and G. Lay. BioLegend. Recipient: S.M. Anthony. Univ. of Iowa

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3:45 Immune dysregulation with STAT3 gain-of-function. 4:00 AID deficiency greatly improves survival and diminishes M.A. Cooper. Washington Univ. Sch. of Med. in St. renal pathology in the BXSB mouse model of SLE. Louis. C.M. Leeth, J. Zhu, A. Potter, M. Hasham, 4:15 Novel immunodeficiencies from the ICID network. M. Richwine and D.C. Roopenian. Virginia J. Chou. Harvard Med. Sch. Polytechnic Inst. and State Univ. and Jackson Lab. 4:45 Central immune tolerance and human autoimmunity. (116.12) M.S. Anderson. Univ. of California, San Francisco. 4:15 sCD83 alleviates experimental autoimmune uveitis 5:15 Elucidating molecular mechanisms of a novel inherited through disrupting the regulation of Rab1a/LRRK2 immunodeficiency-immunodysregulation disorder. on F-actin rearrangements. W. Lin. Shandong Acad. H. Su. NIAID/NIH. of Med. Sci., China. (116.2) 4:30 Type-1 interferons inhibition of interleukin-10 signaling 40. NATIONAL INSTITUTE OF ALLERGY AND in T cells in type 1 diabetes development. M. Iglesias INFECTIOUS DISEASES (NIAID) SYMPOSIUM: Lozano, M. Chicco, D. Bibicheff, G. Brandacher IMAGING TISSUE-SPECIFIC IMMUNITY and G. Raimondi. Johns Hopkins Univ. Sch. of Med. (116.8) NIH-Sponsored Session 4:45 Regulation of FOXP3 expression by c-Rel O- GlcNAcylation. T.J. de Jesus, J. Tomalka, FRI. 3:45 PM—ROOM 25ABC S. Shukla, F. Staback, R. Agarwal, J. Centore CHAIRS: J.J. BREEN, D. FOWELL and P. Ramakrishnan. Case Western Reserve 3:45 T cell navigation within inflamed skin. D. Fowell. Univ. of Univ. (116.15) Rochester. 5:00 The cellular basis of the PD-1/PD-L1 regulatory 4:15 Immune pathology from the molecular scale on up. pathway in diabetic autoimmunity in the NOD G. Nolan. Stanford Univ. mouse. H. Hu, X. Wan, P. Zakharov and 4:45 Microscopy imaging of cellular immune responses in the E.R. Unanue. Washington Univ. Sch. of Med. (116.5) nasal mucosa. R. Gonzalez. Harvard Univ. 5:15 Essential role of IL-17A in Tregs induction in 5:15 Host-pathogen interactions that lead to T cell priming. autoimmune uveitis. W.P. Chong, Y. Zhong, C. Hunter. Univ. of Pennsylvania. M. Mattapallil, J. Chen and R.R. Caspi. Sun Yat- sen Univ., China and NEI, NIH. (116.6) 5:30 CD300c is a negative regulator of T cell immunity. 41. GERMAN SOCIETY FOR IMMUNOLOGY (DGFI) L. Lai, C. Cui, M. Su and Y. Lin. Univ. of SYMPOSIUM: NUCLEIC ACID IMMUNITY Connecticut. (116.3) Guest Society Symposium 43. B CELLS AND TfH CELLS FRI. 3:45 PM—ROOM 26AB Block Symposium CHAIRS: G. HARTMANN, V. HORNUNG, A. ROERS — 3:45 German Society of Immunology. T. Kamradt. Univ. of FRI. 3:45 PM ROOM 31ABC Jena, Germany. CHAIRS: T.L. ROTHSTEIN, Z. FABRY 3:55 Cooperation of DNases and cGAS in immune sensing fi of DNA. G. Hartmann. Univ. of Bonn, Germany. 3:45 Production of peanut-speci c IgE in a food allergy 4:13 Mechanisms of pathogenic chronic activation of model is promoted by T follicular regulatory cells intracellular DNA sensing. A. Roers. Technische via an IL-10-dependent pathway. M.M. Xie, H. Liu, Universitat¨ Dresden, Germany. K. Yang and A. Dent. Indiana Univ. Sch. of Med. 4:31 DNA-induced inflammasome activation. V. Hornung. (121.1) Univ. of Munich, Germany. 4:00 Interleukin-27-producing B cells are critical regulators of 4:49 RNA modifications impairing the RIG-I pathway. immunity during persistent viral infection. M. Schlee. Univ. of Bonn, Germany. I. Pratumchai, Z. Huang, J. Zak and J.R. Teijaro. 5:07 Insights into innate DNA sensing through the cGAS- Scripps Res. Inst. (121.4) fl STING pathway. A. Ablasser. Ecole´ Polytechnique 4:15 Distinct antibody repertoire of cerebral spinal uid B Fed´ erale´ de Lausanne, Switzerland. cells from healthy controls. S. Husain-Krautter, 5:25 Therapeutic approaches to type 1 interferonopathies. D. Vos, J.A. Gallego, A.K. Malhotra and M.A. Lee-Kirsch. Technische Universitat¨ Dresden, T.L. Rothstein. Delaware Psychiatric Ctr., Western Germany. Michigan Univ. Homer Stryker MD Sch. of Med., Weill Cornell Med. Col. and Zucker Hillside Hosp. (121.6) 4:30 The surprising role of indoleamine 2,3-dioxygenase in 42. BASIC AUTOIMMUNITY: IMMUNOREGULATION supporting the survival of bone marrow-resident long- Block Symposium lived plasma cells. S.M. Lightman, L.M. Carlson and K.P. Lee. Roswell Park Cancer Inst. (121.7) FRI. 3:45 PM—ROOM 30CDE 4:45 T follicular helper cell recruitment to the ischemic brain. CHAIRS: H-C. HSU, P. RAMAKRISHNAN L.T. Kissel, A. Rayasam, J. Kijak, Y.H. Choi, M. Hsu, K. Kovacs, M. Sandor and Z. Fabry. 3:45 Overexpression of Pbx1-d, a novel splice isoform of Univ. of Wisconsin, Madison, Univ. of California, Pbx1 associated with lupus susceptibility, regulates San Francisco, Med. Col. of Wisconsin and Univ. regulatory T cell plasticity. S-C. Choi, C. Cornaby of Wisconsin Sch. of Med. and Publ. Hlth. (121.10) and L. Morel. Univ. of Florida. (116.4)

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5:00 Induction of T cell-independent hypermutated and 5:30 The Ikaros zinc finger transcription factor Eos regulates + + protective IgG and IgA antibody responses by CD4 TH1 and CD8 TC1 differentiation programs. TLR4-BCR or TLR5-BCR co-engagement. B.K.N. Sreekumar, M.D. Powell, K. Read, J. Zafar, C.E. Rivera, D. Chupp, H. Yan, J. Im, J. Wang, D. Jones, C. Baker, I.C. Allen and K.J. Oestreich. H.N. Sanchez, S. Wu, J. Taylor, H. Zan, Z. Xu and Virginia Polytechnic Inst. and State Univ., Carilion P. Casali. Univ. of Texas Hlth. Sci. Ctr. San Antonio. Sch. of Med., Virginia Polytechnic Inst. and State (121.11) Univ. and Virginia-Maryland Col. of Vet. Med. (128.8) 5:15 Clonal selection of cross-reactive memory B cells dominates recall responses against heterologous 45. RESIDENT MEMORY IN flaviviruses without a requirement for secondary TUMOR IMMUNOTHERAPY affinity maturation. R.Wong,J.Richner, H.Zhao,M.J.Shlomchik,M.S.Diamondand Block Symposium F D. Bhattacharya. Washington Univ., St. Louis and FRI. 3:45 PM—ROOM 29ABCD R Univ. of Pittsburgh. (121.13) 5:30 T follicular regulatory cells reduce proliferation and CHAIRS: J. MILNER, M.J. TURK I downregulate induction of costimulatory molecules 3:45 Resident memory (TRM) cells sustain immunity to cancer on human Tfh and B cells. I. Sayin, C. Smith, at sites of frequent metastasis. A. Molodtsov, M. Buggert, M.R. Betts and D.H. Canaday. Case K. Lewis, J. Han, J. Vella, Y. Zhao, B. Malik, Western Reserve Univ., Karolinska Inst., Sweden P. Zhang, F. Kolling, C. Cheng, Y.H. Huang, and Perelman Sch. of Med., Univ. of Pennsylvania. C. Angeles and M.J. Turk.GeiselSch.ofMed., (121.16) Dartmouth Col. (138.1) 4:00 Tissue-resident memory T cells mediate melanoma 44. CD4+ T CELL DIFFERENTIATION surveillance and are targets of immunotherapy. AND FUNCTION S.L. Park, A. Buzzai, J.L. Hor, M. Effern, S.N. Christo, S.N. Mueller, M. Holzel, Block Symposium J. Waithman, L.K. Mackay and T. Gebhardt. FRI. 3:45 PM—ROOM 32AB Univ. of Melbourne, Australia, Telethon Kids Inst., Australia and Univ. of Bonn, Germany. (138.2) CHAIRS: L. D’Cruz, V. Lazarevic 4:15 Focal tumor ablation by irreversible electroporation 3:45 Novel Foxp3 regulators discovered by a genome-wide augments immunotherapy to promote tumor growth CRISPR screen. C.S. Loo and Y. Zheng. Salk Inst. control and formation of tumor antigen-specific tissue- for Biological Studies. (128.1) resident memory CD8+ T cells. B.J. Burbach, 4:00 CIS inhibits Treg-intrinsic TH2 program and suppresses S.D. O’Flanagan, M.R. Rollins, J.R. Slaughter, allergic airway inflammation. X.O. Yang, H. Zheng, K.M. Young, M. Song, Q. Shao, S.M. Azarin, X. Wu, R-L. Jiang, E. Castillo, C. Chock, Q. Zhou, J.C. Bischof and Y. Shimizu. Univ. of Minnesota. M. Liu and C. Dong. Univ. of New Mexico Sch. of (138.3) Med. and Tsinghua Univ., China. (128.2) 4:30 Immune pressure against ovarian cancer depends on 4:15 Id2 is necessary for differentiation and survival of antigen-specific TRM T cells. C.M. Anadon Galindo, adipose-resident Tregs. A.B. Frias, E.J. Hyzny, J. Perez Sanz, S. Biswas, K.K. Payne, X. Yu, L.Y. Beppu, H.M. Buechel and L.M. D’Cruz. Univ. T.L. Costich, R. Chaurio Gonzalez and of Pittsburgh Sch. of Med. (128.3) J.R. Conejo-Garcia. Moffitt Cancer Ctr. and Res. 4:30 ICOS signaling in visceral adipose tissue regulatory Inst. (138.4) T cell homeostasis and function. K.L. Mittelsteadt 4:45 Sphingosine-1-phosphate receptor 1 loss mediates and D.J. Campbell. Univ. of Washington and T cell sequestration in bone marrow in the setting Benaroya Res. Inst. (128.4) of intracranial tumors: a novel mode of cancer- 4:45 Role of Ets transcription factors in the development of induced immunosuppression. D.S. Wilkinson, TH9 cells. R.P. Kharwadkar, B.J. Ulrich, Y. Fu and P. Chongsathidkiet, C. Dechant and P. Fecci. M.H. Kaplan. Indiana Univ. Sch. of Med. (128.5) Duke Univ. Med. Ctr. (138.5) 5:00 Prolonged activation in CD4+ T cells results in extensive 5:00 Epigenetic targeting of Brd4 constrains CD8+ T cell mitochondrial remodeling despite the metabolic differentiation during infection and cancer. dominance of aerobic glycolysis. B. Akkaya, J.J. Milner, C. Toma, K. Omilusik, H. Nguyen, A. Roesler, B.P. Theall, J.A. Al Souz, P. Miozzo, B. Yu, A. Delpoux, T. Yoshida, S. Quon, A. Dey, J. Traba, M. Smelkinson, J. Kabat, D. Dorward, S.M. Hedrick, K. Ozato, S. Crotty, M.E. Pipkin and S.K. Pierce and M. Akkaya. NIAID, NIH and NHLBI, A.W. Goldrath. Univ. of California, San Diego, NIH. (128.6) Stanford Univ., NICHD, NIH, La Jolla Inst. for 5:15 Egr2 deficiency significantly impairs the development of Immunology and Scripps Res. Inst. (138.6) pathogenic TH17 cells. Y. Gao, Y. Wang, Y. Guan, 5:15 Therapeutic antibody discovery in lung tumors by B cell N.J. Bouladoux, T. Break, M.S. Lionakis, receptor sequencing. K.J. Kramer, N. Raju, Y. Belkaid and V. Lazarevic. NCI, NIH and NIAID, A. Greenplate, K. Pilewski, P. Massion and NIH. (128.7) I. Georgiev. Vanderbilt Univ. Med. Ctr. (138.7)

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46. NOVEL STRATEGIES AND THEIR FUNCTIONS 47. AAI-BD BIOSCIENCES INVESTIGATOR AWARD FOR PREVENTING RESPIRATORY INFECTIONS PRESENTATION AND LECTURE The AAI-BD Biosciences Investigator Award recognizes Block Symposium an early-career investigator who has made outstanding FRI. 3:45 PM—ROOM 30AB contributions to the field of immunology.

CHAIRS: Y. YASUTOMI, T.M. ROSS Awards Lecture 3:45 Mucosal delivery of nanofiber booster vaccine Generously supported by BD Biosciences enhances generation of antigen-specific memory FRI. 4:30 PM—BALLROOM 20BCD T cells in the lung parenchyma. M.A. Files, P. Bharaj, T.B. Saito, J. Rudra and J.J. Endsley. CHAIR: J.L. FLYNN Univ. of Texas Med. Br. and Washington Univ. in St. Louis. (139.2) Recipient: F.J. Quintana. Brigham and Women’s Hosp., Harvard 4:00 Intravenous Bacille Calmette-Guerin provides Med. Sch. protection across a dose spectrum in a Rhesus 4:30 Introduction and Award Presentation. J.L. Flynn. Univ. macaque model of tuberculosis. J.J. Zeppa, of Pittsburgh Sch. of Med., AAI President; and P.A. Darrah, S. Pokkali, J.A. Hackney, R. Balderas. BD Biosci. P.A. Maiello, C.A. Scanga, D.J. Laddy, P.L. Lin, 4:35 Environmental control of CNS inflammation. R.A. Seder, M. Roederer and J.L. Flynn. Univ. of F.J. Quintana. Brigham and Women’s Hosp., Pittsburgh Sch. of Med., VRC, NIAID, NIH and Harvard Med. Sch. AERAS. (139.3) 4:15 SOCS1 antagonist-expressing recombinant BCG enhances anti-tuberculosis protection in a mouse 48. DISTINGUISHED LECTURE model. Y. Yasutomi. Natl. Inst. of Biomed. ANDREA J. TENNER Innovation, Hlth. and Nutrition, Japan. (139.4) Distinguished Lecture 4:30 Antigen-presenting cell targeted, adjuvant-free mucosal — vaccine induces protection against pneumococcal FRI. 6:00 PM BALLROOM 20BCD infection. S. Kumar, R. Sunagar and E.J. Gosselin. CHAIR: D. MASOPUST Albany Med. Col. (139.6) — 4:45 Immunity of a Klebsiella Pneumoniae vaccine independent 6:00 Complement: primitive yet powerful new discoveries of antigen-specific antibody. N. Iwanaga, I. Sandquist, in immunity and the nervous system. A.J. Tenner. K. Chen, E.B. Norton, J.R. Moreno and J.K. Kolls. Univ. of California, Irvine. Tulane Univ. Sch. of Med., Univ. of Pittsburgh Sch. of Med. and Univ. of Rochester Med. Ctr. (139.7) 49. CAREERS IN BIOTECH: PANEL DISCUSSION 5:00 Robust immune response and protection generated by AND NETWORKING a polyanhydride-based nanoparticle vaccine utilizing Career Development Session the RSV prefusion F protein and/or M protein. L. Stephens, K.A. Ross, S.M. Hartwig, Sponsored by the AAI Education Committee J.S. McLellan, B. Narasimhan, K.L. Legge and Generously supported by the Allen Institute for S.M. Varga. Univ. of Iowa, Iowa State Univ. and Immunology Univ. of Texas, Austin. (139.11) 5:15 The impact of pre-existing B-cell memory in the FRI. 7:00 PM—ROOM 32AB response to influenza vaccination. R.B. Abreu. CHAIR: K.A. CASEY Univ. of Georgia, Athens. (139.19) 5:30 Neuraminidase inhibition governs protection efficacy of Many opportunities exist in biotechnology for scientists with broadly neutralizing anti-influenza hemagglutinin advanced degrees. There are positions in laboratory research, stem antibodies. I. Kosik, D. Angeletti, program management, business development, regulatory affairs, J.S. Gibbs, M. Angel, K. Takeda, M. Kosikova, clinical trials oversight, medical liaison, and more. This panel V. Nair, H.D. Hickman, H. Xie, C.C. Brooke and features scientists employed in a variety of positions discussing J.W. Yewdell. NIAID, NIH, CBER, FDA and Univ. of their career paths and the skills required for success in each. Illinois, Urbana-Champaign. (139.20) Following the panel discussion, enjoy casual conversation with the speakers and other scientists from biotech at a networking reception. PANELISTS: • Don’t forget to visit the Poster Sessions. C.L. Butts. Biogen. • Authors will be present from 2:30 PM – 3:45 PM S. Crampton. aTyr Pharma, Inc. Friday – Sunday to share their findings. • L. Salter-Cid. Gossamer Bio. • K. Sauer. Torque Therapeutics.

18 FRIDAY—POSTER SESSIONS FRIDAY POSTER SESSIONS

Posters on Display: 9:30 am – 4:30 pm Author Presentation Time: 2:30 pm – 3:45 pm

50. BASIC AUTOIMMUNITY: GENETIC AND P352 50.12 Molecular and cellular biomarkers that NON-GENETIC TRIGGERS discriminate juvenile idiopathic arthritis from septic arthritis. N. Nziza, M. Cren, A. Carbasse, P. Mahe, M. Delpont, Poster Session D. Louahem, J. Pene, H. Chevassus, M. Khalil, T. Mura, FRI. 2:30 PM—EXHIBIT/POSTER HALL C. Jorgensen, P. Louis-Plence, E. Jeziorski, I. Duroux- F Richard and F. Apparailly. INSERM U1183, Univ. Hosp. of R P340 50.1 Crispr/Cas9 gene editing targeted to an intron Montpellier and La Colombiere` Hosp., France. I of a novel isoform of the b-subunit of thyroid stimulating P353 50.13 Environmental exposure to 17a-ethinyl hormone in peripheral leukocytes. J.R. Klein and estradiol augments kidney disease and TLR7/9 signaling in H.N. Pawar. Univ. of Texas Hlth. Sci. Ctr., Houston. female autoimmune-prone MRL/lpr mice. M.R. Edwards, P341 50.2 X-chromosome inactivation maintenance is R. Dai, T.E. Cecere, B. Heid and S.A. Ahmed. Virginia perturbed in T cells from lupus mouse models and human Polytechnic Inst. and State Univ. lupus patients. M. Anguera. Univ. of Pennsylvania. P354 50.14 Effect on mental health of narcotics among P342 50.3 p38 MAP kinase signaling in microglia plays a individuals with autoimmune conditions. N. Nedley and fi sex-speci c protective role in CNS autoimmunity. F.E. Ramirez. Weimar Inst. and Nedley Clin. D.N. Krementsov and M. McGill. Univ. of Vermont. P355 50.15 Educational program impacts suicidal thoughts P343 50.4 In vivo depletion of microRNA-183-96-182 of individuals with autoimmune conditions. F.E. Ramirez, cluster alleviates autoimmunity in B6-lpr lupus mice. N. Nedley and T. Queva. Nedley Clin. and Weimar Inst. Z. Wang, B. Heid, R. Lu, D. Khan, S.A. Ahmed and P349 50.16 Role of acetylcholine receptors in cholinergic R. Dai. Virginia-Maryland Col. of Vet. Med. pathway-mediated protection against autoimmune diabetes. P344 50.5 Pro-autoimmune genetic risk variant, PTPN22 B.K. Al-Ramadi, J.A. George, G. Bashir, M.M. Qureshi, 1858C>T accelerates formation of tertiary lymphoid structures Y.A. Mohamed, N. Elsayed and M.J. Fernandez- in a mouse model of type 1 diabetes. S.E. Schmiel, Cabezudo. United Arab Emirates Univ., Col. of Med. and K. Marquardt and L.A. Sherman. Scripps Res. Inst. Hlth. Sci., United Arab Emirates. P345 50.6 A hypomorphic Ephb2 gene variant contributes P356 50.17 miR-140-5p regulates encephalitogenic T cell to autoimmune diabetes in NOD mice associated with altered differentiation through DNA methylation and mitochondrial Mapk3 activities in B-lymphocytes. Q. Wang, H.D. Chapman, metabolism. H. Guan, S. Zhu, X. Zhang, F. Huang, L. Wu, J.J. Racine and D. Serreze. Jackson Lab. D. Hou, Z. Zheng, M. Yu and L. Ge. Stomatology Hosp. of P346 50.7 Developmental exposure to environmental Guangzhou Med. Univ., China. toxicant trichloroethylene alters DNA methylation in P357 50.18 Transcription factor T-bet is required for polycomb protein binding regions in effector/memory CD4 + pathogenicity of GM-CSF-only Th cells in experimental T cells from autoimmune-prone mice. S.J. Blossom, autoimmune encephalomyelitis. J. Rasouli, B. Ciric, S. Byrum, C.L. Washam, J.D. Patterson, K.K. Vyas and G. Casella, S. Yoshimura, G-X. Zhang and A. Rostami. K.M. Gilbert. Univ. of Arkansas for Med. Sci. Thomas Jefferson Univ. P347 50.8 Distinctions in gene-expression in PBMC from male and female SLE patients. M. Olferiev, D. Fernandez, 51. FROM THERE TO HERE, FROM HERE TO D. Greenman, M. Peng, K. Kirou and M.K. Crow. Hosp. for Special Surgery. THERE: INFLAMED THINGS P348 50.9 Unmasking a killer: discovery of a gene that ARE EVERYWHERE controls the pathogenic activation of CD8 T cells in type 1 Poster Session diabetes. C. Ye, D.V. Serreze, Y-G. Chen and J.P. Driver. — Univ. of Florida, Jackson Lab. and Med. Col. of Wisconsin. FRI. 2:30 PM EXHIBIT/POSTER HALL P350 50.10 Epigenetic programming underpins B cell P358 51.1 PDLIM4: target of JMJD3 regulates CD4 T cell dysfunction in human SLE. C. Scharer, E. Blalock, T. Mi, trafficking by connecting S1P1 and cytoskeleton. C. Fu. Texas B. Barwick, S. Jenks, B. Neary, D. Patterson, T. Deguchi, A&M Univ. Health Sci. Ctr. E-H. Lee, C. Wei, I. Sanz and J.M. Boss. Emory Univ. Sch. of P359 51.2 WITHDRAWN Med. P362 51.3 TSPAN33 regulates endocytosis and P351 50.11 Evaluating the role of candidate gene, csf3r, for migration of human B lymphocytes by regulating the plasma sex-linked susceptibility to lupus-like disease in mice. membrane tension. I.C. Navarro-Hernandez, E. Acevedo- M.R. Gubbels Bupp and A.E. Woodfin. Randolph Macon Col. Ochoa, O. Lopez-Ortega,´ R. Fragoso-Soriano, A. Galvan-´ Hernandez,´ A. Antillon,´ I. Ortega-Blake, J.M. Hernandez-´ Hernandez´ and J.L. Maravillas-Montero. CINVESTAV-IPN, Mexico and Natl. Autonomous Univ. of Mexico, Mexico.

19 FRIDAY—POSTER SESSIONS

P363 51.4 Type1 IFN signaling on Tregs modulates the P361 51.16 Blimp-1 transcriptionally induced by growth migration of myeloid derived suppressor cells. S. Tanwar, factors, TNF-a and TLR ligands inhibits keratinocyte A. Metidji and E.M. Shevach. NIAID, NIH. migration and inflammation but enhances cell migration in P364 51.5 Limited recirculation of cytotoxic NK cells squamous cell carcinoma. W-W. Lin and D-Y. Huang. Natl. during normal homeostasis in humans. L. Hertwig, Taiwan Univ., Taiwan. M. Buggert, J.J. Knox, S. Nguyen, E. Sparrelid, P366 51.17 Role of CXCR3 in natural killer cell migration to M.A. Ivarsson, H. Wedemeyer, Y. Dori, M.G. Itkin, melanoma cells. E.J. Park, Y.J. Kang, H.K. Lee, H.S. Kim, M.R. Betts and N.K. Bjorkstr¨ om¨ . Karolinska Inst., J.T. Hong, Y. Kim and S-B. Han. Chungbuk Natl. Univ., South Karolinska Univ. Hosp., Sweden, Perelman Sch. of Med., Korea. Univ. of Pennsylvania, Essen Univ. Hospital, Essen, P374 51.18 CXCL9/10 producing cell clusters optimize Th1 Germany and Children’s Hosp. of Philadelphia, Penn Med., cell positioning for interaction with antigen presenting cells. Hosp. of the Univ. of Pennsylvania. S.G. Negatu, H. Prizant and D.J. Fowell. Univ. of Rochester P365 51.6 Epithelial cell-derived chemokines induce DC Sch. of Med. and Dent. recruitment to the gastric epithelium upon H. pylori infection. P375 51.19 Follicular dendritic cell migration is promoted M. Hashimi, T.A. Seberll, B. Sidar, J.N. Wilking and by the expression of matrix metalloproteinase 3 through TNFɑ- D. Bimczok. Montana State Univ. ERK1/2-AP-1 signaling. K. Yong-Woo, H-K. Pak and P367 51.7 Exit of human cutaneous resident memory C-S. Park. Asan Med. Ctr., Univ. of Ulsan Col. of Med., Korea. CD4 T cells that enter the circulation and seed distant skin P377 51.20 Multi-parametric cell-based inflammation sites. P.A. Morawski, M. Klicznik, B. Hoellbacher, assays for cytokines and cell surface antigens. S. Varkhande, S. Motley, T. Duhen, I. Gratz and E. Cromwell, B. Cho, O. Hoxha, N. Bristol, C. Olsen and D.J. Campbell. Benaroya Res. Inst. and Univ. of Salzburg, O. Sirenko. Protein Fluidics and Molec. Devices, LLC. Austria. P378 51.21 PIEZO1 forms an adhesive-mechanosensitive P368 51.8 Dendritic cell-induced dissemination of complex with activated LFA-1 on T lymphocytes. A.V. Aguilar, Mycobacterium tuberculosis into the central nervous system. B. Benson, J. Rathkey, L. Correa, L. Li, J. Myers, T.E. Gilpin, F.R. Walter, M. Herbath, M. Sandor and J. Tomalka, H. Kennelley, D. Abbott, R. Ransohoff and Z. Fabry. Univ. of Wisconsin, Madison. A. Huang. Case Western Reserve Univ. and Biogen. P369 51.9 Selective recruitment of lethal pro- inflammatory macrophages in sepsis by MIF but not D-DT 52. CYTOKINES REGULATING INFLAMMATION (MIF-2). P.V. Tilstam, W. Schulte, T. Holowka, B-S. Kim, M. Piecychna, G. Pantouris, E. Lolis, L. Leng, J. Bernhagen Poster Session and R. Bucala. Yale Univ. Sch. of Med., Universitatsmedizin¨ FRI. 2:30 PM—EXHIBIT/POSTER HALL Berlin, Germany, Uniklinik RWTH Aachen, Germany and Ludwig-Maximilians-Univ. Munich, Germany. P406 52.1 Mass-cytometry reveals global immune P370 51.10 Germinal center organization mediated by T- remodeling with multi-lineage hypersensitivity to type I bet-dependent expression of CXCR3 and CCR6. J.N. Peel, interferon in Down syndrome. K.A. Waugh, A. Pandey, S.L. Stone, C.D. Scharer, J. Boss and F.E. Lund. Univ. of K.R. Jordan, K.P. Smith, R.E. Granrath, S. Khanal, Alabama, Birmingham and Emory Univ. E.T. Butcher, A.L. Rachubinski, JA. McWilliams, P371 51.11 Intranodal dendritic cell relocalization during P. Araya, R. Minter, T. Dimasi, K.L. Colvin, D. Baturin, inflammation impacts T cell immunity. J.M. Leal, B. Olin A.T. Pham, M.D. Galbraith, M.E. Yeager, K.D. Sullivan, and M.Y. Gerner. Univ. of Washington Sch. of Med. C.C. Porter, E.W. Hsieh and J.M. Espinosa. Linda Crnic P372 51.12 Modulation of ILC2 trafficking and effector Inst. for Down Syndrome, Univ. of Colorado Anschutz Med. functions in ILC2-driven airway hyperreactivity. B.P. Hurrell, Campus and Emory Univ. Sch. of Med. L. Galle-Treger, E. Howard, P. Shafiei Jahani, S. Santosh, P404 52.2 A circulating NAD biosynthetic enzyme is a fl ’ P. Soroosh and O. Akbari. Univ. of Southern California Keck novel modulator of in ammation. A. Manago , V. Audrito, Sch. of Med. and Janssen Pharmaceutical Companies of F. Mazzola, L. Sorci, F. Gaudino, K. Gizzi, D. Incarnato, ’ Johnson & Johnson. G. Minazzato, A. Iannillo, A. Varriale, S. D Auria, P373 51.13 Monocyte activation in cardiovascular disease G. Mengozzi, G. Politano, S. Olivero, N. Raffaelli and through inflammatory signaling associated with CD11c S. Deaglio. Univ. of Turin, Italy, Polytechnic Univ. of function. A.A. Hernandez, G.A. Foster, Y. Dai, Marche, Italy, Italian Institute for Genomic Med., Italy, AOU ` K.R. Rivara, K. Bailey, G.D. Singh and S.I. Simon. Univ. Citta della Salute e della Scienza, Italy, Institute of Food of California, Davis. Science, CNR, Italy and Politecnico di Torino, Italy. P376 51.14 Epithelial membrane protein 2 regulates P379 52.3 Function of protein kinase CK2 in innate fl transepithelial migration of neutrophils into the inflamed immune cells in neuroin ammation. H. Qin, W. Yang, airspace. W-C. Lin, K. Gowdy, J. Madenspacher, Z. Yan and E. Benveniste. Univ. of Alabama, Birmingham. R. Zemans, K. Yamamoto, M. Lyons-Cohen, H. Nakano, P405 52.4 RGC-32 regulates expression of insulin-like K. Janardhan, C. Williams, D. Cook, J. Mizgerd and growth factor binding proteins in astrocytes. A. Tatomir, M. Fessler. NIEHS, NIH, East Carolina Univ., Univ. of D. Boodhoo, V. Nguyen, C. Cudrici, T. Badea, V. Rus Michigan and Boston Univ. Sch. of Med. and H. Rus. Univ. of Maryland Sch. of Med., NHLBI, NIH P360 51.15 CNS HIV virus persistence irrespective of CD4 and NEI, NIH. T cell trafficking. A. Kohlmeier, J. Lipscomb, J-F. Li, A. Santos Tino, A.M. Anderson and J.A. Johnson. CDC and Emory Univ. Sch. of Med.

20 FRIDAY—POSTER SESSIONS

P402 52.5 Bone morphogenic protein receptor 1a and its P400 52.17 A critical role for IL-37 in regulatory T cell ligands as a signaling circuit modulating immune response. maintenance and CD4+ T cell inhibition. D.G. Osborne, P. Kraj, M. Kuczma, C. Simms, M. Pietrzak, L. Ignatowicz, J. Domenico, C.A. Dinarello and M. Fujita. Univ. of P. Muranski and L. Browning. Old Dominion Univ., Georgia Colorado Sch. of Med. State Univ., Ohio State Univ. and Columbia Univ. Med. Ctr. P418 52.18 Investigating epidermal T cell function by C-C P403 52.6 Ovarian tumor domain-containing ubiquitin chemokine receptor 6. S. Bshara-Corson, I. Gonzalez, aldehyde binding protein 1 inhibits IL-6 production by N. Miranda and J. Jameson. California State Univ., San regulating Nur77 stability. S-H. Baek and H.Z. Pei. Col. of Marcos. Med., Yeungnam Univ., South Korea. P407 52.19 Detecting IL-1b release with a rapid, P419 52.7 CXCL13 and other co-expressed homogeneous, bioluminescent immunoassay. M.A. O’Brien, influence in the lung adenocarcinoma (LUAD) TIME (tumor A. Lindstedt, D. Lazar and J. Cali. Promega Corp. immune microenvironment). C.D. Young, T.L. Griffen, P417 52.20 Peripheral blood CD115 (CSF-1R) expression F K. Carey, C.D. Dill, S.K.K. Nunez and O. Adebayo. is anticoagulant- and time-dependent. N.V. Acuff, R Morehouse Sch. of Med. A.A. Divekar and X. Yang. BioLegend, Inc. P409 52.8 Multivariate analysis of genes expressed in the P408 52.21 Development of a high sensitivity 10-plex I colorectal tumor immune microenvironment driven by human cytokine assay using Simoa Planar Array CXCL13. S.K. Nunez, T.L. Griffen, C. Young, C.D. Dill, technology. J. Lambert, C. Zarozinski, J. Johnson, O. Adebayo, K. Carey and J.W. Lillard. Morehouse Sch. Y. Yan, D. Rissin, P. Stadler and A. Ball. Quanterix. of Med. P420 52.22 Development of a high throughput, bead- P415 52.9 The association between the statistical based flow cytometry panel for T-helper cell cytokine significance of the AUC and measure of stochastic quantitation. J. O`Rourke, C. Weldon, L. Keenan and superiority when modeling cytokines: an example from colon M.B. Carter. Essen Biosciences. cancer. F. Qeadan, L. Stalter and E. Beswick. Univ. of New P421 52.23 EBI3 impacts Leishmania braziliensis-induced Mexico and Univ. of Utah Sch. of Med. inflammation in localized cutaneous leishmaniasis. A.K.M. de P411 52.10 Interleukin-37 promotes colitis-associated Santana, G. Gupta, C. Gomes, A. Turatti, R. Bueno Filho, carcinogenesis via SIGIRR-mediated cytotoxic T cells V. Carregaro, A. Roselino, R. Almeida and J. Silva. Univ. of exhaustion. J. Li, X. Teng, X. Wei, Z. Wang, F.L. Zeng, São Paulo, Brazil, Univ. of Manitoba, Canada, Univ. of Brazil, H. Zhou and H. Zheng. West China Hosp., Sichuan Univ., Brazil and Federal Univ. of Sergipe, Brazil. and Collaborative Innovation Ctr. for Biotherapy, China. P412 52.11 TNF targeting small molecule attenuates 53. LYMPHOCYTE DEVELOPMENT colonic inflammation in acute DSS-induced colitis mice. O. Cho, Y-J. Jeong and T-H. Heo. Catholic Univ. of Korea, Poster Session South Korea. FRI. 2:30 PM—EXHIBIT/POSTER HALL P410 52.12 Inhibition of ubiquitin-specific processing proteases 10 and 13 modulates IL-10 and TNF-a production P430 53.1 Development of group-3 innate lymphoid cells in response to LPS in murine macrophages. P.M. Shah, via Tox2-dependent pathway in gut. A. Das, Y. Wang, X. Lu, H. Talwar and L. Samavati. Wayne State Univ. Sch. of Med. C. Harly, J. Kaye and A. Bhandoola. NCI, NIH, China Natl. P416 52.13 Human IL10 promoter haplotypes confer GeneBank, China, Univ. of Nantes, France and Cedars-Sinai differential outcomes to experimental colitis in humanized Med. Ctr. BAC mice. V. Vacharathit, J. Ma, D.C. Gunasekera, P431 53.2 Does TNF-a regulate thymic T cell P. Shah, A. Sheh, C.F. Brayton, M.T. Whary, J.G. Fox developmental block in mice with dysregulated expression and J.H. Bream. Johns Hopkins Univ. Sch. of Med., Johns of Ly-6A? A.K. Bamezai, S. Moxham and A. Patel. Hopkins Univ. Bloomberg Sch. of Publ. Hlth. and Villanova Univ. Massachusetts Inst. of Technol. P437 53.3 TCR signal strength shapes functional P401 52.14 Human interleukin-2 receptor beta mutations imprinting during CD4 T cell development. G. Verstichel, associated with defects in immunity and peripheral tolerance. N. Thiault, K. Kakugawa, A. Chen, H. Iwaya, I. Takazawa Z. Zhang, F. Gothe, P. Pennamen, J. James, D. McDonald, and H. Cheroutre. La Jolla Inst. for Immunology and RIKEN, C. Mata, Y. Modis, A. Alazami, M. Acres, W. Haller, Japan. C. Bowen, R. Doffinger, J. Sinclair, S. Brothers, P438 53.4 TCR-ligand interactions are required for Y. Zhang, H. Matthews, S. Naudion, F. Pelluard, murine epidermal Vg3Vd1 T cell development. H. Alajlan, Y. Yamazaki, L. Notarangelo, J. Thaventhiran, D. Witherden, O.D. Garijo, R. Kelly, H.K. Komori and K. Engelhardt, H. Al-Mousa, S. Hambleton, C. Rooryck, W.L. Havran. Scripps Res. Inst. K.G.C. Smith and M.J. Lenardo. NIAID, NIH, Univ. of P439 53.5 mTORC1 signaling mediates T cell lineage Newcastle, UK, Univ. of Cambridge, UK, King Faisal choices. D.E. Bastardo Blanco, K. Yang and H. Chi. St. ’ Specialist Hosp. and Res. Ctr., Saudi Arabia, Birmingham Jude Children s Res. Hosp. and Indiana Univ. Sch. of Med. Children’s Hosp., Starship Children’s Hosp., Univ. of P423 53.6 Conditional deletion of the V-ATPase a2- Bordeaux, France and CHU Bordeaux, France. subunit disrupts intrathymic T cell development. P413 52.15 WITHDRAWN T.V. Peterson and J.M. Reynolds. Chicago Med. Sch., P414 52.16 A non-depleting PC61 antibody allows residual Rosalind Franklin Univ. of Med. and Sci. CD25 function that maintains regulatory T cell-mediated P433 53.7 TRAF3IP3 at the trans-Golgi network regulates immune homeostasis. E. Hayes, C. Hagan and NKT2 maturation via MEK/ERK signaling pathway. Q. Ge and D.J. Campbell. Benaroya Res. Inst. and Univ. of Washington. X. Zhang. Peking Univ., China.

21 FRIDAY—POSTER SESSIONS

P435 53.8 Atrophied thymus creates tTreg repertoire P424 53.23 A MYC-inducible tumor-suppressor program holes altering an antigen-specific population in the protects developing B cells from transformation. E. Tonc, periphery. R.R. Thomas, J. Oh, W. Wang and D. Su. Univ. C. Chou, C. Fujii, S. Hsiung and T. Egawa. Washington of North Texas Hlth. Sci. Ctr. Univ. Sch. of Med. P441 53.9 NOD2 regulates distinct pathways of P432 53.24 Modulation of RAG2 interactions with histone endogenous thymic regeneration after injury. S. Kinsella, H3K4me3 through residue Thr490. W.A. Rodgers, J. Byrum, K. Cooper, P. deRoos, L. Iovino, R. Jain and D. Simpson, W. Hoolehan and K. Rodgers. Univ. of J.A. Dudakov. Fred Hutchinson Cancer Res. Ctr. Oklahoma Hlth. Sci. Ctr. P443 53.10 WITHDRAWN P446 53.25 Advancing threespine stickleback as an P445 53.11 CD301b+ SIRPa+ dendritic cells play a non- outbred immunogenetics model by pinpointing the onset of redundant role in inducing clonal deletion in the thymus adaptive immunity. E.R. Niebergall, E.A. Beck, S. Bassham medulla. E.R. Breed and K.A. Hogquist. Univ. of Minnesota. and W.A. Cresko. Univ. of Oregon. P422 53.12 Cell-targeted steroid signaling in the thymus determines T cell repertoire strength. M.D. Taves, 54. MAST CELLS: PHENOTYPE TO FUNCTION P. Mittelstadt, D. Presman, G. Hager and J.D. Ashwell. NCI, NIH and Univ. de Buenos Aires, Argentina. Poster Session P426 53.13 Distinct CD28 signaling requirements FRI. 2:30 PM—EXHIBIT/POSTER HALL determine the alternative fates of thymic agonist selection. M. Watanabe, F. Alkhaleel and R.J. Hodes. NCI, NIH. P447 54.1 Comprehensive characterization of the mast P429 53.14 Modulation of Id3 induces a fetal-specific HEB- cell surface proteome. N.J. Shubin, K. Niino, V. Kasprzak, ’ dependent gamma delta T cell developmental pathway in the R. James and A.M. Piliponsky. Seattle Children s Res. Inst. adult mouse thymus. J.S. Selvaratnam and M.K. Anderson. P448 54.2 Early life adversity programs mast cells toward Sunnybrook Res. Inst., Canada and Univ. of Toronto, Canada. a hyperactive phenotype into adulthood. N.C. Maradiaga, P434 53.15 Perturbation of developmental hematopoiesis C. Pohl, E. Mackey and A.J. Moeser. Michigan State Univ. shapes lung ILC2 immune memory. D.A. Lopez and P449 54.3 Transient suppression and functional A.E. Beaudin. Sch. of Natural Sci., UC Merced. modulation of mucosal mast cells for the treatment of P444 53.16 Regulation of thymic type I IFN expression and allergic disease. Y. Kurashima, Y. Takasato, M. Kiuchi, its role in T cell development. O.C. Salgado Barrero, S.T. Lee, K. Hirahara, S. Murasaki, J. Kunisawa, M. Kubo, E.R. Breed and K.A. Hogquist. Ctr. for Immunology, Univ. of T. Nakayama and H. Kiyono. Chiba Univ., Japan, Keio Minnesota. Univ. Sch. of Med., Japan, Univ. of Tokyo, Japan, Natl. Inst. P428 53.17 CD2-iCre mice reveal a role for ABCB7 in B cell of Biomed. Innovation, Hlth. and Nutrition, Japan and RIKEN, development and bone marrow homeostasis. M.J. Lehrke, Japan. fi S. McCue, M. Rajcula, M. Shapiro and V.S. Shapiro. Mayo P451 54.4 Allergen-induced disul de-linked dimers/ Clin. Grad. Sch. of Biomed. Sciences. oligomers of histamine-releasing factor enhance mast cell P436 53.18 In vitro modeling of human B cell development activation. Y. Kawakami, K. Kasakura, T. Ando, can identify distinct physiopathological patterns in primary Y. Kawakami and T. Kawakami. La Jolla Inst. for antibody deficiency. A. Troilo, C. Wehr, I. Janowska, Immunology and Atopy (Allergy) Res. Ctr., Juntendo Univ. J. Rawluk, J. Thiel, N. Venhoff, G. Herget, B.G. Ochs, Grad. Sch. of Med., Japan. L. Konstantinidis, K. Warnatz, U. Salzer and M. Rizzi. P452 54.5 Neurokinin A renders mast cells responsive to Univ. Med. Ctr. Freiburg, Germany. autocrine IL-10. T.L. Sumpter, Y. Li, M. Rao, D. Gohel, P425 53.19 m6A RNA modification controls transitions L.D. Falo and A.T. Larregina. Univ. of Pittsburgh Sch. of Med. between quiescence and proliferation during B-cell P450 54.6 IL-33 with anti-FceRI Ab induces functional development. Z. Zheng, P.J. Hsu, X-L. Cui, H. Tan, CD25 on human skin mast cells. Y. Fukuoka, B.R. Ward L. Zhang, H. Sun, M. Zhang, J. Peng, C. He and and L.B. Schwartz. Virginia Commonwealth Univ. H. Huang. Univ. of Chicago and St. Jude Children’s Res. Hosp. P453 54.7 miR-155 has positive and negative roles on P427 53.20 Hoxa9 silencing of p16ink4a is essential for cytokine production in mast cells. Z.A. Mohammed and murine lymphopoiesis. K.L. Medina and K.A. Gwin. Mayo G. Gomez. Univ. of South Carolina Sch. of Med. Clin. P454 54.8 Ceramide-CD300f interaction inhibits Mrgprb2- P440 53.21 A critical role for the Slam/SAP signaling mediated mast cell activation and pseudo-allergic drug pathway in the developmental programming of gd T cell reactions in mice. A. Takamori, T. Ando, A. Kaitani, function. J.E. Boyson, V.L. DeVault, S.K. Mistri, L. Mei, A. Maehara, K. Izawa, K. Okumura and J. Kitaura. S.C. Musial, C. Spear, J.A. Dragon, A. Veillette and Juntendo Univ. Graduate Sch. of Med., Japan. O. Dienz. Univ. of Vermont and McGill Univ., Canada. P455 54.9 A review of the evidence for the existence of P442 53.22 MicroRNA-142 is an essential negative and relationship between hypermobile Ehlers-Danlos regulator of B cell maturation and malignant transformation. syndrome, postural orthostatic tachycardia syndrome, and N.M. Graham, W-L. Wang, N. Magilnick, J. Lee, H. Wang, mast cell activation syndrome. A. Kohn and C. Chang. B. Zhang, G. Marcucci, M. Muschen, E. Reyes and Florida Atlantic Univ. Col. of Med. and Joe DiMaggio ’ M.P. Boldin. City of Hope Beckman Res. Inst., Syst.s Biol., Children s Hosp. Beckman Res. Inst., City of Hope and Gehr Family Ctr. for P456 54.10 Histamine-mediated autocrine signaling in Leukemia Res., Hematology Malignancies and Stem Cell mesenteric perilymphatic mast cells and its role in the Transplantation Inst. regulation of lymphatic immuno-physiology. S. Pal, O.Y. Gasheva, D. Zawieja, C.J. Meininger and A.A. Gashev. Texas A&M Univ.

22 FRIDAY—POSTER SESSIONS

P457 54.11 Selective serotonin reuptake inhibitors P470 55.9 Effector CD8 T cell infiltration into the skin to suppress mast cell function. T. Haque and J. Ryan. Virginia mediate contact hypersensitivity responses requires TLR4 Commonwealth Univ. signaling on precursors of Gr-1+CXCR2+ bone marrow cells. P458 54.12 The HMGCR inhibitor fluvastatin induces D. Kish and R.L. Fairchild. Cleveland Clin. apoptosis and autophagy in primary and neoplastic mast P472 55.10 Silencing of PD-L2/B7-DC by topical cells. B.O. Barnstein, P.A. Paez, J.M. Dailey, application of small interfering RNA Inhibits elicitation of R.M. Finnegan and J.J. Ryan. Virginia Commonwealth Univ. contact hypersensitivity. E. Furusawa, T. Ohno, S. Nagai, P459 54.13 STAT5b dimers and tetramers are critical for T. Noda, T. Komiyama, K. Kobayashi, H. Hamamoto, mast cell function. K.N. Kiwanuka, J. Lin, W.J. Leonard and M. Miyashin, H. Yokozeki and M. Azuma. Tokyo Med. and J.J. Ryan. Virginia Commonwealth Univ. and NHLBI, NIH, MD. Dent. Univ., Japan and MEDRx, Japan. P460 54.14 Comparing mast cell immunometabolism shifts P473 55.11 The transcription factor EPAS1 links DOCK8- induced by IgE mediated and non-IgE mediated degranulation. deficiency to atopic skin inflammation via IL-31 induction. F R.P. Mendoza, C.C. Anderson, J.R. Roede and J.M. Brown. K. Kunimura and Y. Fukui. Kyushu Univ., Japan. R Univ. of Colorado Anschutz Med. Campus. P475 55.12 A proposed role for interleukin-6 in the P461 54.15 Perinatal androgens drive sex differences in modulation of Th2 asthmatic responses. E.M. McLaughlin I mast cell phenotype and severity of mast cell disease. and B. Leon-Ruiz. Univ. of Alabama, Birmingham. E. Mackey and A.J. Moeser. Michigan State Univ. P477 55.13 Pre-treatment with lipopolysaccharide protects P462 54.16 Skin microbiome regulates SCF level in against a normally lethal respiratory viral infection. J. Resiliac, Keratinocytes and defines mast cell maturation. C-C. Wu, M. Rohlfing, J. Santoro, S-R.A. Hussain and M.H. Grayson. Z. Wang and A. Di Nardo. Univ. of California, San Diego. The Ohio State Univ. and The Res. Inst. at Nationwide Children’s Hosp. 55. MECHANISMS OF ATOPIC DISEASE P464 55.14 Probiotic Lactobacillus GG attenuates pulmonary inflammation through interfering the crosstalk Poster Session between intestinal microbiota and ILC2 in asthmatic mice. FRI. 2:30 PM—EXHIBIT/POSTER HALL G. Peng, Z. Liu, Y. Wang, D. Ge and Y. Hao. Beijing Univ. of Chinese Med., China. fi P465 55.1 Analysis of allergen-speci c T cell and IgE P476 55.15 C-X3-C chemokine receptor 1 regulates reactivity in milk and egg allergic children in response to immunopathogenesis during fungal asthma. M.S. Godwin, progressive forms of baked milk and egg food extracts. M.J. Jones, Z. Yu, S. Matalon and C. Steele. Univ. of V.M.J. Schulten, M. Chen, S. Laubach, S. Leonard and Alabama at Birmingham Sch. of Med. and Tulane Univ. Sch. B. Peters. La Jolla Institute, Univ. of California, San Diego, of Med. ’ Univ. of California, San Diego, Rady Children s Hosp. San P463 55.16 Dimethyl fumarate attenuates T helper type 2‐ Diego and La Jolla Inst. for Immunology. mediated allergic airway inflammation by modulating dendritic P468 55.2 Oral tolerance to peanut allergy is mediated by cell function. A.K. Jaiswal, M. Sandey, A. Suryawanshi, CTLA-4-positive regulatory T cells. J.W. Krempski, K. Iijima, R.C. Cattley and A. Mishra. Auburn Univ. T. Kobayshi and H. Kita. Mayo Grad. Sch. and Mayo Clin. P474 55.17 Suppression of allergic airway inflammation by fi P701 55.3 Identi cation of a novel mechanism of Th2 MCPIP1 through suppression of IL-5-producing Th2 cells. polarization in mouse CD4+ T cells through nuclear factor J. Liu, Q. Wang, H. Ning and R. Hou. Saint Louis Univ. erythroid 2-like 2 (Nrf2) regulation. R.C. Kennedy, S. Liu, P478 55.18 Profile of dendritic cells surface biomarkers in A.E. Turley, R.A. Freeborn and C.E. Rockwell. Michigan nasal and oral mucosa of human subjects reactive to grass State Univ. pollen and house dust mites. F.E. Rivera-Mariani, H. Srour, P479 55.4 Gut oxidative responses by chronic exposure R. Fomenko, S. Bellinger, A. Stateman and J. Baguley. to pollutants enhance IgE production via PGE2-dependent Larkin Univ. Col. of Biomed. Sci. and Larkin Univ. Resp. and mechanism. E. Kim, A. Bonnegarde-Bernard, S.O. Opiyo, Immunology Project Lab. B.M. Ahmer, E. Comet-Boyaka and P.N. Boyaka. The Ohio P700 55.19 a-MSH induces CD4+CD25+FOXP3+ cells State Univ. and suppress activation of PBMCs from pediatric patients P467 55.5 Characterization of protein allergens in a with allergic conjunctivitis. J.E. Nieto, M. Jimenez´ Mart´ınez, mouse model of wheat-induced anaphylaxis. V. Gangur, S. Fest, I. Casanova, J. Ayala, L.A. Salazar and R. Jorgensen, H. Gao, Y. Jin, J. Salloum, D. Jian and H. Velazquez´ . Universidad Nacional Autonoma´ de Mexico,´ P.K.W. Ng. Michigan State Univ. Mexico and Instituto de Oftalmolog´ıa, Mexico. P466 55.6 Immune-markers for assessment of wheat P702 55.20 The role of tyrosine kinase Itk in T helper 17 allergenicity in mice: comparison of adjuvant-free vs. alum- and T regulatory cells in IL17 mediated hypersensitivity adjuvant based models. V. Gangur, Y. Jin, H. Gao, pneumonitis. J. Elmore, C. Carter, W. Huang, N. Koylas, R. Jorgensen and P.K.W. Ng. Michigan State Univ. A. Bennett and A. August. Col. of Vet. Med., Cornell Univ. P471 55.7 An epigenetic link between the gut microbiome P703 55.21 Augmented co-stimulatory repertoire of and immune responses in atopy. A. Cait, M.R. Hughes, gd-T cell pool in pediatric peanut allergic patients. M. Bilenky, J. Cait, D. Pepin, M. Hirst, W.W. Mohn and L.B. Watkin, O. Hassan, C.M. Davis and S. Anvari. Baylor K. McNagny. Univ. of British Columbia, Canada. Col. of Med. P469 55.8 The bone marrow-derived Gr-1+CXCR2+ cells are required for T cell infiltration into the skin challenge site to elicit contact hypersensitivity responses are inflammatory monocytes expressing FasL and perforin. D. Kish and AAI Membership has many advantages! R.L. Fairchild. Cleveland Clin. Visit AAI Booth 1101 to learn more today.

23 FRIDAY—POSTER SESSIONS

56. T CELL REGULATION AND FUNCTION P718 56.15 Runx1 is a key regulator of T cell anergy. D.N. Wilfahrt, F-C. Hsu, S. McCue, M. Rajcula and Poster Session V. Smith Shapiro. Mayo Clin. FRI. 2:30 PM—EXHIBIT/POSTER HALL P719 56.16 Differential modulation of T cell activation. P. Swain, Y. Kam, N. Romero and B.P. Dranka. Agilent P704 56.1 Regulation of CD8+T-lymphocytes by eEF-2K. Technologies. J.K. Das and J. Song. Texas A&M Hlth. Sci. Ctr. P720 56.17 PD-1 regulates response to bystander P705 56.2 Metabolic shift induced by systemic activation activation of memory CD8 T cells. C. Le, C. Dunai, of T cells in PD-1-deficient mice perturbs brain monoamines L.T. Khuat and W.J. Murphy. Univ. of California, Davis. and emotional behavior. M. Miyajima, B. Zhang, M. Guerrini, P721 56.18 Lung-migratory dendritic cells traffic into the Y. Sugiura and S. Fagarasan. RIKEN, Japan, Keio Univ. Sch. spleen after influenza virus infection. M.M. Jenkins, of Med., Japan and Ctr. for Integrative Med. Sci., RIKEN. H. Bachus, B. Leon-Ruiz and A. Ballesteros-Tato. Univ. P706 56.3 Selective inhibition of gelatinases modulates of Alabama at Birmingham, Sch. of Med. cellular energetics in CD4+ T-cells. L.C. Onwuha-Ekpete, P723 56.19 Lymph node conduits transport virions for rapid D. Tokmina-Roszyk and G.B. Fields. Florida Atlantic Univ. T cell activation. G.V. Reynoso, A.S. Weisberg, P707 56.4 TSC1-mTOR-controlled metabolic-epigenetic J.P. Shannon, D.T. McManus, L. Shores, J.L. Americo, crosstalk underlies DC control of CD8+ T cell homeostasis. R.V. Stan, J.W. Yewdell and H.D. Hickman. NIAID, NIH H. Xiao, L. Shi, X. Chen, A. Zang, T. Li and J. Yang. Inst. and Dartmouth Geisel Sch. of Med. Pasteur of Shanghai, China and Lanzhou Univ., China. P722 56.20 Rapid activation of brain resident memory P708 56.5 T-cell microvilli constitute immunological T cells following neurological insults. K. Ayasoufi, synaptosomes that are specialized for intercellular S. Namen, E. Goddery, Z. Tritz, C.E. Fain, L. Yokanovich, communications. C-D. Jun and H-R. Kim. Gwangju Inst. of F. Jin and A.J. Johnson. Mayo Clin., Mayo Clin. Grad. Sch. of Sci. and Technol., South Korea. Biomed. Sci. and Mayo Clin., Rochester, Minnesota. P709 56.6 Sec23b-dependent COPII vesicles regulate P724 56.21 CD160 serves as a negative regulator of T cell immunity. S.H. Kim, R. Khoriaty, R. Valanparambil, NKT cells in acute hepatic injury. K-M. Lee, G. Park, S-R.J. Wu, A. Taylor, H. Fujiwara, D. Peltier, I. Henig, T-J. Kim, J. Kim, S-A. Lim and Y-X. Fu. Korea Univ. Col. Y. Sun, C. Zajac, K. Oravecz-Wilson, M. McClune, of Med. and Univ. of Texas Southwestern Med. Ctr. S. Brabbs, R. Ahmed, D. Ginsburg and P. Reddy. Univ. P725 56.22 Anti-viral CD8+ T cell responses are impaired of Michigan Med. Sch. and Emory Univ. by endogenous n-3 polyunsaturated fatty acids. Y-J. Seo, P710 56.7 Commensal polysaccharide-induced T-cell S. Kim, Y-B. Cho, K-W. Kang and S-M. Lee. Chang Gung communication and peripheral immune regulation. Univ., Taiwan and Chonbuk Natl. Univ., South Korea. J.Y. Zhou, M.B. Jones, C.A. Alvarez, J.L. Johnson and B.A. Cobb. Case Western Reserve Univ. Sch. of Med. P711 56.8 CTL-derived exosomes enhance the activation 57. TREGS AND TH17 of CTLs stimulated by low-affinity peptides. Z. Xiao, S-W. Wu, Poster Session L. Li and Y. Wang. Univ. of Maryland, College Park. — P712 56.9 Antigen presentation by CD301b+ dermal FRI. 2:30 PM EXHIBIT/POSTER HALL dendritic cells dictates CD4+ T cell fate. N. Tatsumi, P726 57.1 Hematopoietic stem progenitor cells prevent A. Iwasaki and Y. Kumamoto. Rutgers New Jersey Med. chronic stress-induced Tregs expansion in an IL12- Sch. and HHMI. dependent manner. D. Yin, Y. Caudle and H. Zhang. East P713 56.10 You are what you eat: CD46 regulated amino Tennessee State Univ. acid usage dictates T cell function. E.E. West, S. Freeley, P727 57.2 Phenotypic and functional characterisation of M.M. Kaminski, S. Veenbergen, D-Y. Lee, L. St. John- expanded antigen-specific regulatory T cells towards clinical Williams, J.W. Thompson, D.R. Green, S. Scholl-Buergi, translation. J. Bianchi, R.I. Azevedo, A.I.S. Vieira, D. Ligeiro, D. Karall, M. Huemer and C. Kemper. NHLBI, NIH, Kings Col. C.L. da Silva and J.F. de Lacerda. IMM, FMUL, CF, Lisbon, London, United Kingdom, St. Jude Children’s Res. Hosp., Spain, CSTL, IPST-IP, Spain and IST-iBB. Erasmus Univ. Med. Ctr., The Netherlands, Duke Univ., P728 57.3 A protective role of IFN-g in T cell-mediated Med. Univ. of Innsbruck, Austria and Univ. Children’s Hosp., colitis by regulation of Treg/Th17 via induction of indoleamine- Zurich, Switzerland. 2,3-deoxygenase. S.G. Zheng, Z. Xu and J. Wang. Penn P714 56.11 PAR1 signaling is involved in TCR-mediated State Col. of Med. CD8 T cell granule exocytosis. M.M. Smith, H. Chen, P729 57.4 Human natural regulatory T cells recognize R.B. Hasley, T. Karpova and M. Catalfamo. NIAID, NIH, peptides of the heavy constant region of immunoglobulins NCI, NIH and Georgetown Univ. Sch. of Med. presented by IgG+ B cells. L-E. Hsieh, J. Sidney, P715 56.12 Immune modulation caused by synthetic N. Behnamfar, J.C. Burns, D. Boyle, G.S. Firestein, opioids during CD4+ T cell activation. B.J. Llorens and A. Sette and A. Franco. Sch. of Med., Univ. of California, A.D. Levine. Case Western Reserve Univ. San Diego and La Jolla Inst. for Immunology. P716 56.13 The costimulatory molecule ICOS promotes P730 57.5 CD71+erythroid cells promote Tregs and via establishment of resident memory CD8+ T cells. C. Peng, ectonucleotides CD39 and CD73 modulate T cell responses. H. Borges da Silva, H. Wang and S. Jameson. Univ. of S. Elahi, S. Shahbaz and P. Koleva. Univ. of Alberta, Canada. Minnesota. P731 57.6 Deubiquitinase CYLD controls the plasticity of P717 56.14 Secondary stimulation of CD4 T cells Treg cells by regulation of Scinderin expression. J. Lee, generates an exhaustion phenotype. G.S. Wolf and Q. Wan, J. Han, S. el Baghdady, S. Geels, C. Elly and N.J. Singh. Univ. of Maryland, Baltimore. Y-C. Liu. La Jolla Inst. for Immunology.

24 FRIDAY—POSTER SESSIONS

P732 57.7 Helios deletion in CD4+T cells induces pTregs P745 57.20 Recently alloactivated CD4+CD8-CD25+T that inhibit memory recall responses. V. Penna, M. Skadow, regulatory cells express CD8alpha and are potent E.M. Shevach and A.M. Thornton. NIAID, NIH and Yale Univ. suppressor cells. B.M. Hall, N.D. Verma, C.M. Robinson, P733 57.8 Regulatory T cells limit unconventional C. Wang, A. Sharland, G. Tran, P. Wilcox and memory to preserve the capacity to mount protective CD8 S.J. Hodgkinson. Univ. of New South Wales, Australia and memory responses to pathogens. J.B. Graham, A.S. Da Sydney Univ., Australia. Costa, J.L. Swarts and J.M. Lund. Fred Hutchinson P746 57.21 Evaluation of regulatory T cell mediated Cancer Res. Ctr. and Univ. of Washington. senescence of T effector cells. J.J. Bauer, C. Langsdorf, P734 57.9 An agonist TIGIT mab suppresses regulatory Y-Z. Hu, S-J. Huang, Y. Wu, X. Wang, S. Clarke, T cell activity via an IL-2-mediated mechanism. B.H. Jones, T. Jackson and V. Calderon. Thermo Fisher Scientific. C. Liu, M. Swiecki, B. Strake, E. Chi and P. Bansal-Pakala. P747 57.22 Construction of CAR-iTreg (chimeric antigen Janssen Pharmaceutical Co. of Johnson & Johnson. receptor-inducible Treg) for inducing tolerance in F P735 57.10 Negative feedback control of autoimmunity by transplantation. H-j. Won, Y-H. Kim and C-G. Park. Seoul R a novel population of regulatory unconventional CD8+ T cells. Natl. Univ. Col. of Med. I. Marrero, H. Sheng, I. Maricic, S.S. Fanchiang, S. Zhang, I D. Sant’Angelo and V. Kumar. Univ. of California, San Diego 58. MYELOID CELLS and Rutgers Univ. P736 57.11 CD4+ T-helper 17 signature cytokine, IL-17, Poster Session mediates CD4 resistance to immune suppression. FRI. 2:30 PM—EXHIBIT/POSTER HALL M.P. Crawford, S. Sinha, P.S. Renavikar and N.J. Karandikar. Univ. of Iowa. P748 58.1 HIF-1a is essential for T cell suppression by P737 57.12 RNA-binding protein PCBP1 shapes tolerance murine LP-BM5 retrovirus infection-augmented monocytic and immune response by constraining the formation of myeloid derived suppressor cells. K.A. Green, R.A. Cramer regulatory T cells. E.A. Ansa-Addo, H-C. Huang, and W.R. Green. Dartmouth Geisel Sch. of Med. S. Iamsawat, X-Z. Yu, P.H. Howe and Z. Li. Med. Univ. of P749 58.2 Myeloid responders to programmed cell death. South Carolina and Hollings Cancer Ctr., Med. Univ. of South M.N. Messmer, A.G. Snyder, M.Y. Gerner and A. Oberst. Carolina. Univ. of Washington. P738 57.13 Human Tc17 cells harbor potent immune P750 58.3 Rapid Isolation of untouched mouse MDSCs. suppressive potential, whereas Tc1 cells lack suppressive F. Antignano, M. Messing, M.R. Hughes, K. McNagny, ability. P.S. Renavikar, M.P. Crawford, S. Sinha and A.I. Kokaji, S.M. Woodside, A.C. Eaves and T.E. Thomas. N.J. Karandikar. Univ. of Iowa Hlth. Care. STEMCELL Technol., Canada and Univ. of British Columbia, P739 57.14 A wave of Foxp3+ regulatory T cell Canada. accumulation in neonatal liver plays unique roles in P751 58.4 TRPV4 mediates the macrophage phagocytic maintaining self-tolerance. Q. Ge and M. Li. Peking Univ., and cytokine response to leptin. R.G. Scheraga, A. Perelas, China. S. Abraham, L. Grove, B.D. Southern, J. Crish and P740 57.15 Short-chain fatty acids regulate regulatory M. Olman. Cleveland Clin. T cells and intestinal pathology during oral mucosal P752 58.5 Creatine shapes macrophage polarization by infection. N. Bhaskaran, E. Schneider and P. Pandiyan. reprogramming L-arginine metabolism. L. Ji, X. Zhao, Case Western Reserve Univ., Sch. of Dental Med. B. Zhang, L. Kang, W. Song, B. Zhao, W. Xie, L. Chen P741 57.16 LAG-3+-induced regulatory T cells confer and X. Hu. Inst. for Immunology and Sch. of Med., Tsinghua infectious tolerance with suppression of IFN-g response Univ., China, Sch. of Pharmaceutical Sci., Tsinghua Univ., decoupled from reserved proliferation. C-T. Huang, China, Hosp. for Special Surgery Res. Div. and the David Z. A. Dutta, C-Y. Hung, T-C. Chen, C-Y. Lin, Y-C. Lin, Rosensweig Genomics Ctr., Tsinghua-Peking Ctr. for Life Sci., C-S. Chang, T-A. Chen and Y-L. Huang. Chang Gung Sch. of Life Sci., Tsinghua Univ., China, School of Mem. Hosp., Taiwan. Pharmaceutical Sci., Tsinghua Univ., China and Inst. for P742 57.17 Regulatory T cells perform antigen specific Immunology and School of Medicine, Tsinghua Univ., China. suppression by depleting cognate peptide-MHC class II via P753 58.6 Immune subsets in the murine pituitary gland trogocytosis. B. Akkaya, Y. Oya, M. Akkaya, J.A. Al Souz, and potential impacts on the HPG axis. D. Nicholas and A.H. Holstein, J. Kabat, O. Kamenyeva, D. Dorward, M.A. Lawson. Univ. of California, San Diego. D. Glass and E.M. Shevach. NIAID, NIH, LIG, NIAID, NIH, P754 58.7 Forkhead box O 6 modulates immunological LISB, NIAID, NIH and RTB, NIAID, NIH. functions of dendritic cells. M.E. Kim, JH. Cho and J.S. Lee. P743 57.18 WITHDRAWN Chosun Univ., South Korea. P744 57.19 c-Maf-dependent Treg cell control of intestinal P755 58.8 The role of the HO-1/heme axis on macrophage cytokine production. R. Choa and TH17 cells and IgA establishes host-microbiota homeostasis. S. Rutz, C. Neumann, J. Blume, A. Kalies and A. Scheffold. T. Kambayashi. Perelman Sch. of Med., Univ. of Genentech, Inc., German Rheumatism Res. Ctr., Germany, Pennsylvania. The Walter and Eliza Hall Inst. of Med. Res. and Christian P756 58.9 TRAF3 is a critical regulator of the expansion of Albrechts Univ., Germany. myeloid-derived suppressor cells in mice. S. Zhu, A. Lalani, D. Sant’Angelo, L.R. Covey and P. Xie. Rutgers Univ. P757 58.10 Magnolol attenuates the cisplatin-induced muscle wasting via M2c macrophage activation. C. Lee, S-Y. Park, D. Min and H. Bae. Kyung Hee Univ., South Korea.

25 FRIDAY—POSTER SESSIONS

P758 58.11 Itaconate inhibits alternative activation of P774 59.4 Ptpn6 inhibits caspase-8- and Ripk3/Mlkl- macrophages by targeting Janus kinase 1. M.C. Runtsch dependent inflammation. B.A. Croker, M. Speir, and L. O’Neill. Trinity Col. Dublin, Ireland. C.J. Nowell, A.A. Chen, J.A. O’Donnell, A.A. D’Cruz, P759 58.12 WITHDRAWN M. Bliss-Moreau, S. Wang, M.A. Kelliher, R. Hakem and P760 58.13 IL-34 differentiation of immunosuppressive M. Gerlic. Boston Children’s Hosp., Monash Inst. of macrophage. K. Kelly-Scumpia, R. Shirazi and R. Modlin. Pharmaceutical Sci., Australia, Harvard Med. Sch., The Univ. of California, Los Angeles. Walter and Eliza Hall Institute of Med. Res., Australia, Univ. P761 58.14 Targeted deletion of CD11b+ macrophage of Massachusetts Med. Sch., Univ. of Toronto, Canada and Tel subtypes alter the acute inflammatory cytokine response in Aviv Univ., Israel. bone healing. J. Cottrell, S. Hozain and D. Touma. Seton Hall P779 59.5 Extracellular calcium-phosphate nanoparticles Univ. activate the NLRP3 inflammasome through CaSR signaling. P762 58.15 Sympathetic nervous tone influences anti- E. Jager,¨ C. Staubert,¨ P. Sungur, S. Hoppener,¨ S. Strobel, tumor immunity by mediating accumulation of myeloid- S. Murthy, M. Rossol and U. Wagner. Leipzig Univ., Germany derived suppressor cells and regulatory T-cells. J.T. Nevin, and Friedrich Schiller Univ. Jena, Germany. W.L. Corwin and P.K. Srivastava. Univ. of Connecticut Hlth. P800 59.6 A sustained small increase in NOD1 Ctr. expression promotes ligand-independent oncogenic activity. P763 58.16 Visualising interaction of monocytes with red L. Rommereim, A.S. Akhade, B. Dutta, C. Hutcheon, blood cells sensitised with “clinically significant” antibodies. N. Lounsbury, C. Rostomily, R. Savan, I. Fraser, M.M. Dean, J. Ji, Y.T. Gu, E. Sauret and R.L. Flower. R. Germain and N. Subramanian. Inst. for Systems Biol., Australian Red Cross Blood Service, Australia and NIAID, NIH and Univ. of Washington Sch. of Med. Queensland Univ. of Technol., Australia. P803 59.7 A loss-of-function single nucleotide P764 58.17 PI3K activated tumors evade tumor immunity polymorphism in cytochrome b5 reductase 3 amplifies the by promoting an inhibitory myeloid microenvironment. response of bone marrow-derived macrophages to high salt. N.B. Collins, R. Al Abosy, B. Miller, K. Bi, R. Manguso, J.A. Jerome, E.R. DeVallance, P.J. Pagano and K. Yates and W.N. Haining. Dana-Farber Cancer Inst., Broad A.C. Straub. Univ. of Pittsburgh Sch. of Med. Inst. of MIT and Harvard and Merck Res. Lab. P769 59.8 Axl-mediated Akt phosphorylation leads to P765 58.18 Fatty acid transporter 2 regulates the mTORC1 activation via NFk-B in renal mesangial cells. suppressive functions of PMN-MDSC in cancer. F. Veglia, W. Shao and Y. Zhen. Univ. of Cincinnati. V. Tyurin, M. Blasi, A. De Leo, L. Donthireddy, C. DiRusso, P770 59.9 TRIM14 promotes endothelial activation via P. Black, V. Kagan and D.I. Gabrilovich. The Wistar Inst., NF-kB signaling pathway. Y. Li, D. Fan and M. Fu. Univ. of Univ. of Pittsburgh, Duke Univ. and Univ. of Nebraska-Lincoln. South Carolina and Univ. of Missouri, Kansas City. P766 58.19 IL-10 and TGF- b differentially regulate gap P772 59.10 Distinct heat shock protein-mediated immune junction formation and membrane transfer in macrophages and responses are induced by macrophages and dendritic cells. macrophage-like cells. E. Eill and S.M. Taffet. Upstate Med. A.L. Sedlacek, L.B. Kinner-Bibeau, Y. Wang, A.P. Mizes Univ. and R.J. Binder. Univ. of Pittsburgh, Colorado State Univ. and Tsinghua Univ., China. 59. INNATE IMMUNE MECHANISMS P773 59.11 Analysis of regulatory elements in the HLA-A, HLA-B, and HLA-C genes provides insights into the specific Poster Session role of each HLA in the immune system. S. Anderson and FRI. 2:30 PM—EXHIBIT/POSTER HALL H. Li. Leidos Biomed. Res., Inc. P775 59.12 CD31 acts as a checkpoint molecule and is P767 59.1 Autophagy-based unconventional secretion of modulated by FcgR-mediated signaling in monocytes. alarmin HMGB1 by keratinocytes plays a pivotal role in J.P. Butchar, G. Merchand-Reyes, F. Robledo-Avila, fl psoriatic skin in ammation. Z. Wang, H. Zhou, H. Zheng, N. Buteyn, S. Gautam, R. Santhanam, K. Fatehchand, X. Teng, X. Wei and J. Li. Sichuan Univ., China. S. Partida-Sanchez and S. Tridandapani. The Ohio State P768 59.2 Exploiting altered enhancer landscapes to Univ., Nationwide Children’s Hosp. and Texas Biomed. Res. decode pathogenic changes in gene expression of diverse Inst. hepatic macrophages. T.D. Troutman, J.S. Seidman, P776 59.13 Changes in myeloid-derived suppressor cell M. Sakai, A. Gola, Z. Ouyang, N.J. Spann, C.M. Bruni, function during neonatal sepsis. J. Vance, T. Rawson, H. Bennett, K. Ego, B-C. Vu, X. Sun, M. Pasillas, M.R. Witt, B.G. Seman, S. Bradford and C.M. Robinson. J.L. Witztum, R.N. Germain and C.K. Glass. Univ. of West Virginia Univ. California, San Diego and NIAID, NIH. P777 59.14 Investigation of the role of Axl receptor in the fi P771 59.3 Dietary soluble ber induces HCC in dysbiotic development of uterine immune tolerance at the onset and mice through a spectrum of immunosuppressive mediators. continuation of pregnancy. E. Konuk, A. Okan, E. Orhan, M. Vijay-Kumar, B.S. Yeoh, V. Singh, R.M. Golonka and E. Katırcı, F. Qulieva and N. Demir. Akdeniz Univ., Turkey. P. Saha. Univ. of Toledo Col. of Med. and Life Sci., The P778 59.15 WITHDRAWN Pennsylvania State Univ. and The Univ. of Toledo Col. of P801 59.16 Retinoic acid-induced expression of CD103 in Med. and Life Sci. human DCs is dependent on p38 MAPK signaling and NFAT1c. M.M. Roe, S. Swain and D. Bimczok. Montana State Univ.

Don’t forget to take advantage of the knowledge-building opportunities presented at the Exhibitor Workshops. Check the Meeting Guide or app for more details.

26 FRIDAY—POSTER SESSIONS

P802 59.17 Knockdown of circular RNA FSCN1 impairs P814 60.11 Dynamic changes in 3D spatial chromatin dendritic cell immune function through regulating the NFKB organization underpin virus-specific killer T cell and Foxo3 signaling pathways. X. Zheng, C. Zhu, Y. Su, differentiation. S.J. Turner, A. Morey, M. Olshansky, B. Wang and D. O’Brien. Univ. of Western Ontario, Canada. P. Collas, Z. He, C. Murre and B.E. Russ. Monash Univ., P804 59.18 Receptor tyrosine kinase Axl plays a protective Australia, Univ. of Oslo, Norway and Univ. of California, San role in the autoantibody-induced arthritis. Y. Wu. Soochow Diego. Univ., China. P816 60.12 gd T cell activation in response to a keratinocyte wound signature. M.D. Johnson, 60. REGULATION OF INNATE AND CYTOTOXIC C. Higginson, S. Tekkam, S. Crooke, J. Lloyd, LYMPHOCYTE RESPONSES: D. Witherden, M.G. Finn and W.L. Havran. Scripps Res. MOLECULAR MECHANISMS Inst. and Georgia Inst. of Tech. P817 60.13 PD-1 is negatively regulated by LSD1 through F Poster Session interactions with Blimp-1 during acute viral infection. R D.K. Neeld, A. Bally, P. Lu, P. Majumder, B. Barwick and FRI. 2:30 PM—EXHIBIT/POSTER HALL J.M. Boss. Emory Univ. Sch. of Med. I P805 60.1 HMGB1-induced ILC2s activate dendritic cells P819 60.14 Identification of TRM subsets with distinct by producing IL-9 in mice asthma. H. Xu, J. Wan, Z. Su and cellular states and memory potential. K. Omilusik, S. Wang. Jiangsu Univ., China. J.J. Milner, N. Kurd, C. Toma, J.T. Chang and P806 60.2 BHLHE40 programs mitochondrial regulation A.W. Goldrath. Univ. of California, San Diego. of resident CD8+ T cell fitness and functionality. C. Li, B. Zhu, P821 60.15 Tracking the in vivo history and fate of IL-2 Y. Son, Z. Wang, B.T. Edelson, T. Hitosugi, J.C. Rathmell, producing CD8 T cells during memory differentiation. H. Dong and J. Sun. Mayo Clin., Washington Univ., St. Louis Y. Yuzefpolskiy, S. Sarkar and V. Kalia. Univ. of and Vanderbilt Univ. Med. Ctr. Washington Sch. of Med. P807 60.3 WITHDRAWN P820 60.16 Trib1 controls antiviral immunity by restraining P808 60.4 The NF-kappa B regulator Bcl-3 is critical factor CD4 and CD8 T cell effector responses during chronic for memory CD8+ T cell generation. H. Jaiswal and infection. K.S. Rome and W.S. Pear. Univ. of Pennsylvania. U. Siebenlist. NIAID, NIH. P818 60.17 Smad signaling determines the fate of P809 60.5 Single cell transcriptomics resolves activation activated CTLs via multiple intersecting signaling pathways. dynamics and cellular states of human blood and tissue T cells. K. Chandiran, J.E. Suarez-Ramirez, Y. Hu, S. Kaech and P.A. Szabo, H.M. Levitin, M. Miron, M.E. Snyder, T. Senda, L.S. Cauley. UConn Hlth., Emory Univ. and The Salk Inst. J. Yuan, Y.L. Chen, E.C. Bush, P. Dogra, P. Thapa, P822 60.18 Delineating the functions of RIPK1 in vivo P.A. Sims and D.L. Farber. Columbia Univ. Med. Ctr. through CRISPR/Cas9-mediated gene editing in mice. P810 60.6 NUR77 has a cell intrinsic role in natural killer X. Zhang, J.P. Dowling and J. Zhang. Thomas Jefferson T cell development and function. A. Kumar, N. Suryadevara, Univ. T.M. Hill, L.E. Gordy, J.S. Bezbradica, L. Wu, P. Acharya, P823 60.19 Simultaneous analysis of mRNA and proteins S.W. Hiebert, L. Van Kaer and S. Joyce. Tennessee Valley in immune cells using the BD™ Single-Cell Multiplexing Kit and Hlth. Care Syst., Vanderbilt Univ. Med. Ctr. and Vanderbilt BD™ AbSeq reagents on the BD Rhapsody™ system for high- Univ. Sch. of Med. resolution interrogation of differential immune regulation. P811 60.7 High spare respiratory capacity is a canonical H-W. Song, G.V. Baracho, N. Bansal, I. Taylor, E. Shum, feature of virtual memory, but not conventional memory CD8 S. Widmann and S. Mortimer. BD Biosciences and FlowJo, T cells, and is driven by IL-15 signaling. N.L. La Gruta, LLC. K.M. Quinn, F. Kraus, L. Formosa, M. Dagley, P824 60.20 Novel expression of bone morphogenic protein E. Saunders, T. Hussain, L. Assmus, A. Costin, J. Clark, 10 in lymphocytes. V.K. Tsiagbe, S. Avina, S. Mills, S. Patel G. Ramm, K. Good-Jacobson, M. McConville and M. Ryan. and Y. Li. Rutgers Univ. Monash Univ., Australia and Univ. of Melbourne, Australia. P812 60.8 Signaling from individual opioid receptors 61. IMMUNOLOGY EDUCATION differentially modulates the functional and phenotypic potential of resting and activated human CD8+ T cells. Poster Session C. Mazahery, S. Valadkhan and A.D. Levine. Case FRI. 2:30 PM—EXHIBIT/POSTER HALL Western Reserve Univ. P815 60.9 TIM-3-dependent regulation of restimulation- P834 61.1 Student outcomes in a cure course using induced cell death sensitivity flips changes in early versus simple model organisms to characterize host-pathogen late-stage human effector T cells. C. Lake, T. Jiang, interactions. M. Snyder and A. Trauth. Towson Univ. and B. Bauman, K. Voss and A.L. Snow. Uniformed Serv. Univ. of Delaware. Univ. of the Hlth. Sci. P826 61.2 Manipulating peripheral blood cell populations P813 60.10 CFTR, which not only serves as a TCR to mimic immune disease states: a novel approach to teach signaling molecule but also function as an anion channel, flow cytometry to undergraduate immunology students. dual-negatively regulates IFN-g production and tumor M. Costabile, H. Nguyen and A. Kenyon. Univ. of South immunity in gd T cells. Y. Duan, G. Li, M. Xu and Z. Yin. Australia, Australia. Jinan Univ., China. P827 61.3 Development and evaluation of an interactive simulation to teach undergraduate immunology students all stages of monoclonal antibody production. M. Costabile. Univ. of South Australia, Australia.

27 FRIDAY—POSTER SESSIONS

P828 61.4 Teaching hemolytic disease of the newborn P844 61.19 The utilisation of clinically relevant (Erythroblastalis fetalis) to undergraduate immunology Immunological research examples for undergraduate students through the use of an interactive simulation. medical sciences education. D. Sika-Paotonu, V. Gu, M. Costabile. Univ. of South Australia, Australia. G. Williams, E. Pinfold, J. Whyte, L. Motu, T. Anitelea, P829 61.5 Development of an interactive simulation and J. Yuhoi and B. Laing. Wellington Sch. of Med. & Hlth. app (PipetteMaster) to teach undergraduate students how to Sci., Univ. of Otago, New Zealand. read, set and use and automatic laboratory pipette. P845 61.20 Contextualisation of immunology based M. Costabile and C. Della Vedova. Univ. of South teaching for undergraduate medical science students that Australia, Australia. supports knowledge application. D. Sika-Paotonu, A. Yang, P830 61.6 The new paradigm shift in microbiology and K. Vaipuna, E. Buckley, H. Bartlett, S. Kalyanasundaram immunology education in Azerbaijan Medical University, Baku, and A. Faatoese. Wellington Sch. of Med. & Hlth. Sci., Univ. of Azerbaijan. N. Fazal, S. Ali, D. Sheriff, D. Brewer and Otago, New Zealand. P. Childs. Chicago State Univ. Col. of Pharm. P846 61.21 An online workshop integrated into P831 61.7 Just in time teaching strategies: from Immunology course to teach pharmacogenomics to the first- implementation to student buy-in. D.M. Brown, year pharmacy students. N. Fazal, R. Joly, N. Jassem, K.R. Brazeal and B.A. Couch. Univ. of Nebraska, Lincoln. M. Edquiban, B. Lakhani and K. Shaikh. Chicago State P832 61.8 A speaking-intensive model for case studies in Univ. Col. of Pharmacy. undergraduate immunology. S. Redmond and A. Mohamed. Radford Univ. 62. CELLULAR MECHANISMS OF INNATE P833 61.9 An intervention to increase accuracy and IMMUNITY I understanding in undergraduate micropipette use. L. Avery, A. Dukes and M. Warner. Children’s Hosp. of Philadelphia Poster Session and Univ. of Pittsburgh. FRI. 2:30 PM—EXHIBIT/POSTER HALL P835 61.10 Maximizing engagement and critical thinking with stories: case studies of all shapes and sizes. K.R. Lukin P865 62.1 Crosstalk between lung epithelial cells and and K. Aviszus. Western Governors Univ. and Natl. Jewish myeloid cells in innate immune defense. X. Liu, M.A. Boyer Hlth. and S. Shin. Perelman Sch. of Med., Univ. of Pennsylvania. P836 61.11 Supporting scientific knowledge P849 62.2 Type III interferons are expressed in fl communication and translation efforts by engaging tuberculosis granulomas and may in uence signaling in appropriately with the Pacific audience. D. Sika-Paotonu, epithelioid macrophages. P. Talukdar and J.T. Mattila. B. Laing, T. Anitelea, T. Uiese, R. Puni, T. Vaipuna and Univ. of Pittsburgh. A. Fa’atoese. Wellington Sch. of Med. & Hlth. Sci., Univ. of P860 62.3 Phenotypic analysis of alveolar macrophage Otago, New Zealand. populations in old mice and their response to Mycobacterium P837 61.12 Cinemimmunology-the use of cinema to learn tuberculosis infection. W.P. Lafuse, M.V.S. Rajaram, Q. Wu, immunology. S. Siddiqui, S. Olk, R. Collier and N. Fazal. J.I. Moliva, J.B. Torrelles, J. Turner and L.S. Schlesinger. Chicago State Univ. Col. of Pharmacy. The Ohio State Univ. and Texas Biomed. Res. Inst. P838 61.13 Using IF AT strategy in the Dental Immunology P862 62.4 Alveolar macrophage responses to curriculum has a beneficial impact on the performance of Mycobacterium tuberculosis reveal human-to-human second year dental students. P. Alard. Univ. of Louisville. variation in important immunobiology pathways gleaned from P839 61.14 Engaging with Pacific communities to support functional genomics study. A. Azad, A. Papp, X. Zhou, effective dialogue, appropriate outreach and scientific M. Pietrzak, M. Wang, E. Arnett, M. Montoya, knowledge translation activity. D. Sika-Paotonu, S. Handelman, G. Rempala, S. Lin, W. Sadee and T. Anitelea, T. Uiese and A. Cockburn. Wellington Sch. of L. Schlesinger. Texas Biomed. Res. Inst., The Ohio State Med. & Hlth. Sci., Univ. of Otago, New Zealand and Wellington Univ. and Univ. of Michigan. East Girls’ Col., New Zealand. P858 62.5 Caspase 11 negatively regulates carbapenem- P840 61.15 Immunology as a basis for STEM related resistant Klebsiella Pneumoniae-induced pneumonia. teaching that is culturally appropriate and engages L. Ghimire, S. Paudel, L. Jin and S. Jeyaseelan. underrepresented high school students. D. Sika-Paotonu Louisiana State Univ. and A. Cockburn. Wellington Sch. of Med. & Hlth. Sci., P853 62.6 Novel role of zinc homeostasis in IL-23 Univ. of Otago, New Zealand. regulation and host defense following bacterial infection. fi P841 61.16 An Immunological basis for improving interest S.C. Hall, D.R. Smith, D.M. Kata asz, K.L. Bailey and and participation of underrepresented student groups in high D.L. Knoell. Univ. of Nebraska Med. Ctr. school science classes. D. Sika-Paotonu, J. Anderson, P857 62.7 Ketogenic diet activates protective gd T cell fl P. Cashin and A. Cockburn. Wellington Sch. of Med. & responses against in uenza virus infection. E.L. Goldberg, Hlth. Sci., Univ. of Otago, New Zealand. R. Molony, S. Sidorov, E. Kudo, V.D. Dixit and A. Iwasaki. P842 61.17 Role modelling Immunology to support STEM Yale Sch. of Med. education outreach efforts for Pacific college students. D. Sika- P867 62.8 Gamma Herpesvirus manipulates HVEM Paotonu. Wellington Sch. of Med. & Hlth. Sci., Univ. of Otago, regulated IL-1b pathway to evade immune responses. New Zealand. W.W. Lin, E. Chapell, G. Brar, T-T. Wu, R. Sun, P843 61.18 STEM knowledge translational outreach B. Baaten and C.F. Ware. Sanford Burnham Prebys Med. efforts: connecting with Immunology in the classroom for Discovery Inst. and Univ. of California, Los Angeles. Pacific intermediate students. D. Sika-Paotonu. Wellington Sch. of Med. & Hlth. Sci., Univ. of Otago, New Zealand.

28 FRIDAY—POSTER SESSIONS

P847 62.9 IL-25 regulates alveolar macrophage exosome P866 62.21 Age and HIV perturb the TB immunity in release in response to LPS. J. Fan, Y. Li and Z. Li. Univ. of regulatory and cytotoxic subpopulations of NKT cells. Pittsburgh Sch. of Med. T. Nishiguchi, G. Mtetwa, A. Kay, G. Maphalala, E. Mace, P848 62.10 Post-traumatic pulmonary infection: the innate A.M. Mandalakas and A.R. DiNardo. Baylor Col. of Med., immune response protects the lung at the expense of the Swaziland Ministry of Hlth., Swaziland and Columbia Univ. healing cutaneous wound. M. Crane, Y. Xu, S.F. Monaghan, B.M. Hall, H.L. Tran, W.L. Henry, 63. CYTOPLASMIC SENSING J.E. Albina and A.M. Jamieson. Brown Univ. and Rhode Island Hosp. Poster Session P850 62.11 Characterization of AIM2 expression in human FRI. 2:30 PM—EXHIBIT/POSTER HALL macrophages during M. tuberculosis infection. C.O. Ontiveros, E. Arnett and L.S. Schlesinger. Univ. of P1200 63.1 WITHDRAWN P870 63.2 Nucleosomal double-stranded DNA triggers F Texas Health Sci. Ctr., San Antonio and Texas Biomed. Res. R Inst. APOL1 expression through the STING-TBK1-IRF3 pathway. P851 62.12 Characterizing the BCG-induced T cell S.E. Davis, A. Khatua and W. Popik. Meharry Med. Col. I independent mechanisms for defense against P879 63.3 The Ca2+ sensor STIM1 regulates the type I Mycobacterium tuberculosis. T. Bickett, E. Creissen, interferon response by retaining the signaling adaptor STING F. Silva Angulo, A. Izzo, L. Izzo and A.A. Izzo. Colorado at the endoplasmic reticulum. J.S. Woo, S. Srikanth, B. Wu, State Univ. Y.M. El-Sherbiny, J. Leung, K. Chupradit, L. Rice, G.J. Seo, P852 62.13 Myeloid-derived suppressor cells from HIV- G. Calmettes, C. Ramakrishna, E. Cantin, D.S. An, R. Sun, infected individuals are defective in innate immunity to T-T. Wu, J.U. Jung, S. Savic and Y. Gwack. David Geffen ’ Mycobacterium tuberculosis thus increasing the risk of Sch. of Med., Univ. of California, Los Angeles, St James s Univ. tuberculosis. A.J. Garg and S.A. Spector. Univ. of Georgia, Hosp., Univ. of Southern California, City of Hope Beckman Athens and Univ. of California San Diego. Res. Inst. and Univ. of California, Los Angeles. fi fl P854 62.14 Involvement of sphingosine kinase during P873 63.4 Proteomic pro ling of autoin ammatory autophagosome formation plays a critical role in controlling diseases, NOMID and CANDLE before and after treatment the growth of Mycobacterium tuberculosis within human with interleukin-1 or with interferon blockade. S. Alehashemi, mesenchymal stem cells. A. Khan, V.K. Singh, L. Mann, M. Sawhney, B. Sellers, A. de Jesus, F. Cheung, R. Papanna, D. Canaday, S.A. David, A.S. Tsetkov and A. Biancotto and R. Goldbach-Mansky. NIAID, NIH. C. Jagannath. Houston Methodist Res. Inst., Univ. of P876 63.5 Lysophosphatidylcholine activates caspase-1 Texas, Houston, Case Western Reserve Univ. and Univ. of by bringing about release of ATP and sensitization of purinergic Minnesota. receptor. S. Ismaeel and A. Qadri. Natl. Inst. of Immunology, P855 62.15 Insulin-like growth factor 1 regulates a India. fl pulmonary niche promoting type 3 innate lymphoid cell P877 63.6 Inhibition of NLRP3 in ammasome prevents development necessary for protection against pneumonia in increase IL1b levels and impairment cognitive in the newborn. J.K. Gray, K. Oehrle, E.G. Acker, I. Lang, pneumococcal meningitis. J.S. Generoso, A. Collodel, N. Cloud and H. Deshmukh. Cincinnati Children’s Hosp. S.R. Ribeiro Junior, C. Julio Faller, B. França Lodetti, Med. Ctr. D.I. Bardini, L. Roque Simões, C. Dagostin, P856 62.16 Role of pulmonary innate immune memory F. Fernandes Gabriel, D. Dominguini, F. Dal-Pizzol and leukocytes in the repeated respiratory infection of influenza T. Barichello. Universidade do Extremo Sul Catarinense, A virus. N. Li. CAMS, China. Brazil and UTHealth. fl P859 62.17 Deletion of MCP-1 enhances susceptibility to P871 63.7 Potassium ef ux and serum amyloid A3 are carbapenem-resistant Klebsiella pneumoniae via modulating involved in IL-1b production by macrophages infected with neutrophil and macrophage function. L. Jin, L. Ghimire, Mycobacterium tuberculosis. B-G. Jung and B. Samten. Univ. S. Paudel, S. Cai and S. Jeyaseelan. Louisiana State Univ. of Texas Hlth. Sci. Ctr. Tyler. P861 62.18 HVEM signaling in pulmonary epithelial cells is P868 63.8 PtdIns4P on dispersed trans-Golgi network fl required for protection against Streptococcus pneumoniae. mediates NLRP3 in ammasome activation. J. Chen and T-F. Chou, K. Hitomi, J-W. Shui, K. Kakugawa, ZJ. Chen. Univ. of Texas Southwestern Med. Ctr. H. Cheroutre and M. Kronenberg. La Jolla Inst. for P869 63.9 Molecular mechanisms of gasdermin D fl Immunology, Inst. of Biomed. Sci., Academia Sinica, Taiwan autoinhibition and recognition by in ammatory caspases. and RIKEN Ctr. for Integrative Med. Sci. T.S. Xiao, Z. Liu, J. Yang, C. Wang and R. Yang. Case P863 62.19 Type 1 interferon expression and signaling Western Reserve Univ. fl occur in spatially-distinct regions in granulomas from P872 63.10 In ammasome-mediated sensing of multi- Mycobacterium tuberculosis-infected cynomolgus macaques. component pore-forming toxins. S.M. Man. Australian Natl. J.T. Mattila. Univ. of Pittsburgh Grad. Sch. of Publ. Hlth. Univ., Australia. P864 62.20 HIV infection associated oxidation of innate P874 63.11 Non-canonical activation of caspase 8 immune proteins in the human lung mucosa alters the host mediates pyroptosis. A. Poltorak. Tufts Univ. response to Mycobacterium tuberculosis infection. A. Akhter, P875 63.12 Calpain drives pyroptotic vimentin cleavage, fi A. Olmo-Fontanez,´ J. Moliva, A. Azad, H. Kelley, J. Scordo, intermediate lament loss, and cell rupture that mediates M. Gavrilin, M. Wewers and J. Torrelles. Texas Biomed. Res. immunostimulation. M.A. Davis, M.R. Fairgrieve, A. den Inst. and The Ohio State Univ. Hartigh, O. Yakovenko, B. Duvvuri, C. Lood, S. Fink, W.E. Thomas and M.J. Gale. Univ. of Washington.

29 FRIDAY—POSTER SESSIONS

P878 63.13 A host cell-intrinsic innate regulatory circuit P1223 64.11 Knockdown of Syk and Hrs in murine limits inflammasome activity and promotes immune escape astrocytes alters immune response following TLR3 of Salmonella inside macrophages. A.S. Akhade, S.M. Atif, stimulation. M.B. Mielcarska, M. Bossowska-Nowicka and B.S. Lakshmi, N. Dikshit, A. Qadri and N. Subramanian. F.N. Toka. Warsaw Univ. of Life Sci. Inst. for Syst. Biol. and Natl. Inst. of Immunology, India. P1224 64.12 TRAF3IP3 negatively regulates type I P1201 63.14 Alarmin(g) outcomes of intracellular LPS interferon signaling by suppressing TBK1. M. Deng, sensing. V. Rathinam, A. Russo, A. Menoret, J.W. Tam, H. Guo, L. Zhang, B.K. Davis, J. Brickey, G. Rabinovich, S. Duduskar, S. Deshmukh and S. Sun and J.P. Ting. Lineberger Comprehensive Cancer A.T. Vella. UConn Hlth., Universidad de Buenos Aires, Ctr., Univ. of North Carolina, Chapel Hill, Dept. of Biol., Argentina and Jena Univ. Hosp. Franklin and Marshall Col., Lancaster, PA and Univ. of P1202 63.15 WITHDRAWN Texas MD Anderson Cancer Ctr. P1225 64.13 Bond tension on neutrophil LFA-1 regulates 64. INNATE IMMUNE SENSING AND SIGNALING membrane calcium flux from the outside-in. V.A.ris Morikis, M.H. Jo, T. Ha and S.I. Simon. Univ. of California, Davis and Poster Session Johns Hopkins Univ. FRI. 2:30 PM—EXHIBIT/POSTER HALL P1226 64.14 Regulation of GLI3 expression by TLR4 signaling. S.J. Matissek and S.F. Elsawa. Univ. of New fi P1206 64.1 Rede ning the TIR domain: from axon Hampshire. degeneration to innate immunity and beyond. K. Essuman, P1228 64.15 Novel monoclonal antibodies for the detection L. Wan, D.W. Summers, R.G. Anderson, Y. Sasaki, X. Mao, of human TLR9. N.V. Acuff, T. Oida, A.A. Divekar and A.K.Y. Yim, F. Monteiro, E-H. Chung, E. Osborne- X. Yang. BioLegend, Inc. Nishimura, J. Dangl, M. Nishimura, A. DiAntonio and P1229 64.16 Induction of innate antiviral immunity through a J. Milbrandt. Washington Univ. Sch. of Med., St. Louis, novel pattern recognition receptor, the RNA helicase DHX16, is Univ. of North Carolina, Chapel Hill and Colorado State Univ. regulated by unanchored K48-linked poly-ubiquitin chains. P1209 64.2 Syk-dependent glycolytic reprogramming in A. Hage, P. Bharaj and R. Rajsbaum. Univ. of Texas Med. Br. dendritic cells regulates IL-1-beta production to fungal- P1205 64.17 Siglec-1 negatively regulates TLR4-mediated assoicated ligands in a TLR-independent manner. E. Amiel, inflammatory response by uniquely controlling Src P.M. Thwe, D. Fritz and J. Snyder. Univ. of Vermont and Tufts phosphorylation at Ser17. D. Yang, Y. Wu and G-Y. Chen. Univ. Univ. of Tennessee Hlth. Sci. Ctr. fi P1211 64.3 Ikaros zinc nger transcription factors as novel P1208 64.18 Conditional disruption of hematopoietic regulators of STAT factor activity. K. Read, B. Sreekumar, protein-1 in mice reveals an essential role for Hem-1 in M.D. Powell, D. Jones and K.J. Oestreich. Virginia Tech. myeloid cell functions. N. Suwankitwat, H. Park, T. Iwata, P1214 64.4 The suppressor of cytokine signaling 1 impairs S. Libby, D. Liggitt and B.M. Iritani. Univ. of Washington. skin host defense in healthy and hyperglycemic mice. P1227 64.19 Sequential exposure to IFNg decreases N. Klopfenstein and H. Serezani. Vanderbilt Univ. and IFNGR and alters myeloid cell IFNg signaling. W.J. Crisler, Vanderbilt Univ. Med. Ctr. E. Eshleman and L.L. Lenz. Univ. of Colorado Sch. of Med. P1215 64.5 IRF3 signaling in stromal cells contributes to P1204 64.20 Role of NLRC5 and IRF1 in the induction of sepsis pathogenesis. W. Walker, J. Harper, C. Lopez, MHC class I. S. Vijayan, T.B. Meissner, K-H. Lee, Y-J. Liu, J. Nellikappallil and E.L. Heipertz. Texas Tech Univ. Hlth. I. Downs, T. Sidiq, C. Zhang, P.J. van den Elsen and Sci. Ctr., El Paso. K.S. Kobayashi. Texas A&M Hlth. Sci. Ctr., Harvard Med. P1217 64.6 NHR-49/PPARa regulates HLH-30/TFEB- Sch. and Leiden Univ. Med. Ctr., The Netherlands. fl mediated innate immune response via a avin-containing P1216 64.21 H3K4me3 profiles of LPS and immune monooxygenase in C. elegans. K. Wani, S. Taubert and complex-activated macrophages. T. Palaga, V. Ruenjaiman J. Irazoqui. Univ. of Massachusetts Med. Sch. and Univ. of and Y-W. Leu. Fac. of Sci., Chulalongkorn Univ., Thailand, British Columbia, Canada. Chulalongkorn Univ., Thailand and Natl. Chung Cheng Univ., P1218 64.7 Cross-talk between MDP/NOD2 and GPIba/ Taiwan. Mac-1 pathways controls production of PGE2 and of IL-1b P1207 64.22 NME4 regulates TLR3 activation and type I IFN and IL-6 cytokines in human monocytes activated with MDP production through autophagy-dependent TRAF6 degradation. adjuvant. M. Zaitseva, F. Liu, Y. Endo, T. Romantseva, B. Sun, X.H. Zhao and R.H. Zhang. Shanghai Inst. of W.W. Wu, R. Shen and H. Golding. CBER, FDA. Biochemistry and Cell Biol., Chinese Acad. of Sci., China. P1220 64.8 Induction of COX-2 gene transcription and prostaglandin E2 (PGE2) production in primary human monocytes by MDP adjuvant: role of MAPK and p300 HAT. F. Liu, T. Romantseva, H. Golding and M. Zaitseva. CBER, FDA. P1221 64.9 Lactic acid suppresses LPS-induced mast cell cytokine production by limiting glycolysis and ATP availability. J.J. Ryan, L.A. Hoeferlin, C.E. Chalfant and H. Caslin. Virginia Commonwealth Univ., Virginia Commonwealth Univ. Sch. of Med. and Univ. of South Florida Morsani Col. of Med. P1222 64.10 Nucleic acid sensing in a 3D hydrogel model of B16F10 mouse melanoma. L. Heller, A. Bulysheva, S. Arpag-Mcintosh, N. Semenova and M. Cemazar. Old Dominion Univ. and Inst. of Oncology Ljubljana.

30 FRIDAY—POSTER SESSIONS

P1212 64.23 TLR-2, TLR-3 and TLR-4 agonists induce P1235 65.8 Interleukin-37 improves aging-associated synthesis of IFN-g in human M1 but not in M2a, M2b and declines in adaptive immunity leading to enhanced M2c macrophages through the activation of S6K1-S6 suppression of Ph+ leukemia. C.J. Henry, E. Eisenmesser, pathwayg. A. Kumar, S. Iqbal, A. Mukerjee, N. Gajnayaka, C.A. Dinarello and J. DeGregori. Emory Univ. Sch. of Med. F. Ahmad and A. Crawley. Univ. of Ottawa, Canada, Hlth. and Univ. of Colorado Anschutz Med. Campus. Canada, Canada and Mount Sinai Med. Sch. New York. P1239 65.9 Keap1-Nrf2 system controls cellular P1213 64.24 Outcomes of ERK signaling differ in metabolism to govern NKT cell homeostasis and effector macrophages and dendritic cells. S.G. Groft, N. Nagy, functions. K. Pyaram, A. Kumar and C-H. Chang. Univ. of S. Shukla, D. Sweet, W.H. Boom and C.V. Harding. Case Michigan Med. Sch. Western Reserve Univ. Sch. of Med. P1231 65.10 The transcription factor TCF1 is a critical target P1219 64.25 Dysregulated CARD9 signaling in neutrophils of ID2 that limits natural killer cell maturation. B.L. Kee, drives inflammation in a mouse model of neutrophilic R. Morman, M. Sun and Z-Y. Li. Univ. of Chicago. F dermatoses. S. Tartey and T-D. Kanneganti. St. Jude P1240 65.11 WITHDRAWN R Children’s Res. Hosp. P1230 65.12 Effects of TNFa signaling on iNKT cell P1203 64.26 Analysis of health and lung injury markers in development, activation and maturation. H. Zhang, I mice treated with TLR4-interacting SPA4 peptide. S. Awasthi, S. Modrak, F. Zhang and A.A. Little. Col. of Pharmacy and N. Rahman, A. Hedrick, V. Awasthi, M. Breshears and Pharmaceutical Sci., Washington State Univ. S. Kosanke. Univ. of Oklahoma Hlth. Sci. Ctr. and P1241 65.13 Single-cell analysis of gd T cells reveals limited Oklahoma State Univ. TCR delta chain diversity in mouse lung Vg4 gd T cells. P1210 64.27 Modeling the stimulatory network of CD16, 2B4 S.K. Mistri, K.J. Hampel, O. Dienz and J.E. Boyson. Univ. and NKG2D in natural killer cell activation. S.Z. Makaryan and of Vermont. S. Finley. Univ. of Southern California. P1236 65.14 Identification of age-related changes in chromatin accessibility and gene expression in T cells from 65. INNATE LYMPHOCYTE DEVELOPMENT, thymus to periphery. A. Achour, G. Chen, A. Sharov, STROMA, AND AGING T. Nguyen, X. Li, M. Patrick, W. Wood III, S. De, K. Becker, W. Peng and N-P. Weng. NIA, NIH and George Poster Session Washington Univ. FRI. 2:30 PM—EXHIBIT/POSTER HALL P1242 65.15 Redox regulation of autophagy in thymic stromal cell function. M.K. Semwal, A.K. Hester, Y. Xiao, P1233 65.1 Single cell sequencing reveals mouse T. Venables and A. Griffith. Univ. of Texas Hlth. at San MAIT cell diversity. S. Chandra, G. Seumois, C. Ramirez, Antonio and Scripps Res. Inst. G. Seo, P. Vijayanand and M. Kronenberg. La Jolla Inst. for P1243 65.16 Catalase expression mediates redox Allergy and Immunology. regulation of promiscuous gene expression in thymic P1234 65.2 Dose-dependent requirements for ETS1 in stromal cells. A.K. Hester, M.K. Semwal, X. Yangming, invariant natural killer T cell development. R.C. Morgan and S. Cepeda, T. Venables and A. Griffith. Univ. of Texas B.L. Kee. Univ. of Chicago. Hlth. at San Antonio and Scripps Res. Inst. P1238 65.3 Assessment of the global chromatin landscape and transcriptome of peripheral iNKT cell subsets. 66. MUCOSAL IMMUNITY DURING INFECTION M.L. Paynich, I. Engel, G. Seumois, S. Liang, S. Herrera de la Mata, A. Sethi, A. Logandha Ramamoorthy Premlal, Poster Session J.A. Greenbaum, P. Vijayanand, A. Rao, J. Scott-Browne FRI. 2:30 PM—EXHIBIT/POSTER HALL and M. Kronenberg. La Jolla Inst. for Immunology and Natl. Jewish Hlth. P1246 66.1 Th17- Mediated Immunity against Co-infection P1245 65.4 Single cell profiling reveals unique stages of of Influenza A virus and Nontypeable Haemophilus influenzae. NK cell development. A.M. Beaulieu. Rutgers New Jersey X. Zhang and H. Shen. Univ. of Pennsylvania. Med. Sch. P1247 66.2 Identification and characterization of lung P1244 65.5 Predicting natural killer cell behavior with commensal bacteria that modulate immune response in mathematical models. A.J. Millan, S. Sindi and J. Manilay. tuberculosis. L. Bernard, A. Colom, M. Cescato, Univ. of California, Merced. C. Cougoule, P. Guilloton, N. Ghebrendrias, F. Capilla, P1232 65.6 Heterogeneity in differentiation capacity A. Alloy, A. Remot, M. Thomas, P. Langella, O. Neyrolles among ILC precursors in human peripheral blood and and G. Lugo-Villarino. Institut de Pharmacologie et de tissues. E. Kokkinou, I. Gutierrez-Perez, R. Vinay Pandey, Biologie Structurale, France, Centre de Physiopathologie de A. Rao, L. Mazzurana, S. Almer, C. Ho¨ og,¨ U. Lindforss, Toulouse Purpan, France and INRA, France. Y. Bryceson and J. Mjosberg¨ . Ctr. for Infectious Med., P1248 66.3 Inducible epithelial resistance protects against Karolinska Inst., Sweden, Karolinska Inst., Sweden, acute viral infection and subsequent CD8+T cell dependent Karolinska Inst., Stockholm, Solna, Karolinska Inst., and lethal immunopathology. S. Wali, J.R. Flores, D. Goldblatt, IBD-Center, Gastroenterology, Karolinska Univ. Hosp., M. Tuvim, B.F. Dickey and S.E. Evans. Univ. of Texas MD Sweden, Karolinska Inst., Sweden. and Karolinska Univ. Anderson Cancer Ctr. Hospital, Sweden. P1251 66.4 Suppression of IL-17 producing type 3 innate P1237 65.7 Sustained E protein activity selectively inhibits lymphoid cells and increased susceptibility to Klebsiella ILC2 development. H.R. Berrett and J. Alberola-Ila. pneumoniae sepsis in neonatal mice exposed to extended Oklahoma Med. Res. Fndn. empiric antibiotics. J. Mirpuri, S. Thomas Babu, X. Niu, D. Kumar and R. savani. Univ. of Texas Southwestern Med. Ctr. and Univ. of North Texas Hlth. Sci. Ctr.

31 FRIDAY—POSTER SESSIONS

P1252 66.5 Human IFNe and IFNa modulate immune and P1267 66.18 Prior Bacillus Calmette-Guerin´ vaccination anti-HIV functions through the differential involvement of IFNa ameliorates the pathogenesis of type 2 diabetes mellitus receptors. V. Pizutelli, C. Tasker, L. Sue, W. Lu and mice infected with Mycobacterium tuberculosis. T. Chang. Rutgers New Jersey Med. Sch., Univ. of North R.K. Radhakrishnan, D. Tripathi, R. Sivangala Thandi, Carolina, Sch. of Med., Chapel Hill and Univ. of Maryland, P. Paidipally and R. Vankayalapati. The Univ. of Texas Sch. of Med. Hlth. Sci. Ctr. at Tyler. P1253 66.6 Novel vaccine adjuvants: exploring the P1268 66.19 Swift protection from flu infections in a systemic potential of rexinoids to influence effector T cell homing to lupus mouse model. G. Abboud, S-C. Choi, W. Li, A. Titov, mucosal sites. K. Manhas, J.N. Blattman, P.A. Marshall, K.K. McKinstry, T.M. Strutt, S. Salek-Ardakani and L. Morel. C.E. Wagner and P.W. Jurutka. Biodesign Ctr. for Univ. of Florida, Univ. of Central Florida and Pfizer, Inc. Immunotherapy, Vaccines, and Virotherapy, Biodesign P1269 66.20 Acetylcholine and cholinergic lymphocytes in Instit., Arizona State Univ. and Sch. of Mathematical and the immune response to influenza. J.A. Phillips, A. Horkowitz Natural Sciences, Arizona State Univ. West. and R. Feuer. San Diego State Univ. P1254 66.7 Mucosal immune mediated protection of the P1256 66.21 CD4+ resident memory T cells dominate CNS following olfactory viral infection. E.A. Moseman. Duke immunosurveillance and orchestrate local recall responses. Univ. Sch. of Med. L.K. Beura, N.J. Fares-Frederickson, E.M. Steinert, P1255 66.8 Host immunity modulates efficacy of fecal M.C. Scott, E.A. Thompson, K.A. Fraser, J.M. Schenkel, microbiota transplantation treatment of Clostridium difficile V. Vezys and D. Masopust. Univ. of Minnesota, Feinberg Sch. infection. M.C. Abt, E.G. Pamer, E.R. Littmann, I. Zarin of Med., Northwestern Univ., Ctr. for Immunology, Univ. of and R.A. Carter. Perelman Sch. of Med., Univ. of Minnesota and Bluebird Bio. Pennsylvania and Mem. Sloan Kettering Cancer Ctr. P1263 66.22 Repeated respiratory bacterial exposures elicit P1257 66.9 Analysis of cholinergic pathway-induced lung-resident memory B cells in the absence of organized alterations at the intestinal mucosa and their association tertiary lymphoid tissue. K.A. Barker, N.M. Smith, with enhanced resistance to lethal bacterial infection. A.T. Shenoy, I.M.C. Martin, M.R. Jones, L.J. Quinton and M.J. Fernandez-Cabezudo, A.A. Al-Mansouri, G. Bashir, J.P. Mizgerd. Boston Univ. Sch. of Med. A. Al-Sbiei, K. Venkatachalam and B.K. al-Ramadi. P1249 66.23 Differential phenotypes and localization of CD8 United Arab Emirates Univ., United Arab Emirates. T cell responses to acute and chronic viral infection. P1258 66.10 M. tuberculosis antigen-specific T-cell function B.K. Hardman and L. Osborne. Univ. of British Columbia, in breast milk of HIV-infected mothers. A.J. Warr, J. Shah, Canada. S. LaCourse, J. Kinuthia, E. Maleche-Obimbo, L. Cranmer, P1250 66.24 WITHDRAWN F. Nguyen, D. Matemo, G. John-Stewart and T. Hawn. Univ. P1270 66.25 An intranasally administered antibody cocktail of Washington, Kenyatta Natl. Hosp., Kenya and Emory Univ. prevents ricin toxin-induced lung inflammation and alveolar P1259 66.11 Peroxisome proliferator-activated receptor macrophage death. N.J. Mantis, Y. Rong and F.J. Torres- gamma suppresses inflammation and bacterial control Velez. New York State Dept. of Hlth. during influenza bacterial super-infection. R. Gopal, A. Mendy, M.A. Marinelli, L.J. Richwalls, P.J. Seger, 67. IMMUNE MECHANISMS AT MUCOSAL SITES S. Patel, K.J. McHugh, H.E. Rich, J.A. Grousd, E. Forno and J.F. Alcorn. Univ. of Pittsburgh and Univ. of Iowa. Poster Session P1260 66.12 WITHDRAWN FRI. 2:30 PM—EXHIBIT/POSTER HALL P1261 66.13 Lung-resident memory CD4 T cells do not divide extensively during protective responses against P1271 67.1 Intestinal permeability and IgA provoke fl Influenza virus. K.K. McKinstry and C.M. Finn. Univ. of immune vasculitis linked to cardiovascular in ammation. Central Florida. M. Noval Rivas, D. Wakita, M. Franklin, S. Chen, P1262 66.14 Spatial distribution of antigen-specific CD8+ M. Yamashita, T.R. Crother, K. Shimada and M. Arditi. T cells in virally infected skin. E. Wynne-Jones, Cedars-Sinai Med. Ctr. J.P. Shannon, G.V. Reynoso and H.D. Hickman. NIAD, NIH. P1272 67.2 Distinct roles of TbRIII and LRP-1 in lactoferrin- + P1264 66.15 Liver macrophages controls Mycobacterium mediated Foxp3 inducible Tregs. S-M. Kim, Y-S. Jang and tuberculosis growth by enhancing autophagy. R. Sivangala P-H. Kim. Kangwon Natl. Univ., South Korea. fl Thandi, D. Tripathi, R.K. Radhakrishnan, P. Paidipally and P1273 67.3 The E3 ligase VHL controls lung in ammation R. Vankayalapati. Univ. of Texas Hlth. Sci. Ctr. Tyler and Univ. by regulating epithelium-ILC2 cross-talk. J. Han, Q. Wan, S. el of Texas Hlth. Sci. Ctr., Tyler. Baghdady, J. Lee and Y-C. Liu. La Jolla Inst. for Allergy and P1265 66.16 T-cell derived acetylcholine aids host defenses Immunology. during enteric bacterial infection with Citrobacter rodentium. P1274 67.4 Exosomes from primary bronchial epithelial V.T. Ramirez, I. Brust-Mascher, M.B. Gardner, J.A. Sladek, cells induce tolerance in human monocyte-derived dendritic M.G. Gareau and C. Reardon. Univ. of California, Davis, Sch. cells. A. Agrawal, C. Monterio and S. Agrawal. Univ. of of Vet. Med. California, Irvine. P1266 66.17 Unrelated respiratory infections compromise P1275 67.5 Mechanisms of antigen transport from the established cellular immunity by promoting apoptosis of pre- female reproductive tract to the gastrointestinal tract. existing lung-resident memory CD8 T cells. S.L. Hayward, S.E. Howe, N. Shillova and V.H. Konjufca. Southern Z.R.T. Li, J.L. Lobby, J.O.P. Eggert and J.E. Kohlmeier. Illinois Univ., Carbondale. fl Emory Univ. Sch. of Med. P1276 67.6 TLR4 signaling regulates an in ammatory response to food allergens. E. Campbell and C. Nagler. Univ. of Chicago.

32 FRIDAY—POSTER SESSIONS

P1277 67.7 High-frequency irreversible electroporation is P1311 67.20 in vitro model for assessing the effect of T an effective tumor ablation strategy that induces inflammatory helper cell cytokines on the barrier function of alveolar type cell death and promotes anti-tumor immunity. V.M. Ringel- II epithelial cells. D. Coello, J.D. Knott and E. Porter. Scaia, R.M. Brock, N.B. White, K. Eden, S.L. Coutermarsh- California State Univ. Ott, M.F. Lorenzo, R.V. Davalos and I.C. Allen. Virginia- P1312 67.21 Formation of human T cell mucosal resident Maryland Col. of Veterinary Med., Virginia Tech., Virginia memory starts in early life with the intestines. T. Connors, Tech. and Virginia Tech-Wake Forest Univ. P. Thapa, M.C. Yopes, R.S. Guyer, M.M. Li, M.E. Snyder and P1278 67.8 Lymphotoxin receptor beta expression by D.L. Farber. Columbia Univ. Med. Ctr. neutrophils prevents metabolic activation and colitis P1313 67.22 WITHDRAWN pathogenesis. D.A. Giles, T. Riffelmacher, S. Zahner, P1309 67.23 Effect of muscarine and atropine on the A.Y. Andreyev, S. McArdle, T. Perez, E. Van der Gracht, production of myeloperoxidase and proinflammatory V. Morris, A. Tumanov and M. Kronenberg. La Jolla Inst. for cytokines in small intestine. A.A. Resendiz-Albor, F Immunology, Univ. of California, San Diego and Univ. of Texas I.M. Arciniega-Martinez, M.M. Santamaria-Chavez, R Hlth. Sci. Ctr., San Antonio. X.A. Rebollar-Ruiz and R. Campos-Rodriguez. Escuela P1279 67.9 BATF is an essential regulator of migratory Superior de Medicina del Instituto Politecnico Nacional, I ILC2 cell fate and function. M.M. Miller, P. Patel, K. Bao, Mexico. T. Danhorn, B. O’Connor and R.L. Reinhardt. Natl. Jewish P1314 67.24 DOCK8 is involved in mucosal immunity and Hlth. and Duke Univ. Med. Ctr. prevents gut inflammation. A.K. Singh, S. Saha, G. Bhise, P1300 67.10 Protective effect of resveratrol on the integrity J. Woods, E. Bettelli and M. Oukka. Seattle Childrens Res. of alveolar and intestinal epithelial barrier in SEB-induced Inst., Benaroya Res. Inst. and Univ. of Washington Sch. of acute lung injury. H.F. Alghetaa, A. Mohammed, Med. M. Nagarkatti and P.S. Nagarkatti. Univ. of South Carolina Sch. of Med. 68. TRANSLATIONAL ADVANCES IN TISSUE P1301 67.11 Single-cell mRNA analysis of colon phagocyte SPECIFIC AUTOIMMUNITY heterogeneity identifies two major macrophage developmental pathways. B. Kang, L.J. Alvarado, M. Lehman, B-H. Kim, Poster Session P. Li, H. Cho, J. He, A. Larochelle and B.L. Kelsall. NIAID, FRI. 2:30 PM—EXHIBIT/POSTER HALL NIH, NHLBI, NIH, NIMH, NIH and NCI, NIH. P1302 67.12 High-dimensional immune atlas of second P1315 68.1 Inducible thymic epithelial cell-based fl trimester human intestinal immunity. L. Konnikova, rejuvenation in thymic aging-associated in ammaging. S. Stras, L. Werner, J. Toothaker, A. Oldham and J. Oh, R. Thomas, W. Wang and D. Su. Univ. of North D. Shouval. Univ. of Pittsburgh and Edmond and Lily Safra Texas Hlth. Sci. Ctr. Children’s Hosp. P1316 68.2 Synergistic effect of IL-27 and retinoic acid on P1303 67.13 Examining the Immune Composition of the the expression of CD39 on mouse Treg cells. T. Maslanka, ł intestinal mucosa by mass cytometry. C.J. Tyler, I. Gregorczyk, A. Jasiecka-Miko ajczyk and L. Lundborg, S. Yeasmin and J. Rivera-Nieves. Univ. of J. Jaroszewski. Univ. of Warmia and Mazury, Olsztyn, California, San Diego. Poland. fi P1304 67.14 Vitamin A signaling regulates pathological P1317 68.3 B-cell speci c duo-conjugates for therapy of epithelial cell shedding via IL-18. N.R. Iyer and autoimmune myasthenia gravis. R. Huda, A. Bahauddin, S. Vaishnava. Brown Univ. X. Fang and X. Wu. Univ. of Texas Med. Br. and First fi P1305 67.15 Mutation of Tgfbr1 leads to non-hematopoietic Af liated Hosp. of Nanchang Medical Univ. fl defects that drive early onset eosinophilic inflammation in the P1324 68.4 Blocking the pro-in ammatory response fl esophagus. K. Laky, J.L. Kinard, A. Guerrerio, M.J. Li and associated with in ammatory bodel Disease with 7- P. Guerrerio. NIAID, NIH, Johns Hopkins Univ. and Johns ketocholesterol. A.K. Bamezai, F. Mallon and Hopkins Univ. Sch. of Med. A. Lawrence. Villanova Univ. and Univ. of Pennsylvania. fi P1306 67.16 Pulmonary resident effector CD4+ T cells fail to P1323 68.5 Development of a novel antigen-speci c effectively utilize glycolysis. L.M. Roberts, T.J. Evans and therapy for autoimmune diabetes using an insulin-ChgA C.M. Bosio. NIAID, NIH. hybrid peptide neoantigen. B. Jamison, K.S. Beard, T. Neef, B. Bradley, R. Baker, R.G. Gill, S.D. Miller and P1307 67.17 Skin-recirculating NK cells express a4b1 integrin, E- ligand, and produce IFNg. G.T. Riley, K. Haskins. Univ. of Colorado and Feinberg Sch. of Med., J. Hunka and G.F. Debes. Thomas Jefferson Univ. and Northwestern Univ. Ludwig-Maximilians-Univ. of Munich, Germany. P1331 68.6 Investigating heme regulation of REV-ERBa P1308 67.18 The Cd8 locus controls the functional activity in Th17 cells. S.A. Mosure, D. Kojetin and conversion of CD4 Th cells to CD4 CTL in the intestine. L.A. Solt. Scripps Res. Inst. fl H. Iwaya, A. Larange, K. Kakugawa and H. Cheroutre.La P1320 68.7 Suppression of in ammatory cytokine Jolla Inst. for Immunology and Lab. for Immune Crosstalk, production and cell proliferation by salt-inducible kinase RIKEN Ctr. for Integrative Med. Sci. inhibition in human myeloid cells is isoform-dependent. P1310 67.19 Aryl hydrocarbon receptor activation does not Z. Shao and A. Symons. Amgen, Inc. impact the number of myeloid-derived suppressor cells in the P1325 68.8 Transplantation of MHC-mismatched mouse spleens of mice immunized with cholera toxin. A.E. King, embryonic stem cell-derived thymic epithelial progenitors E.M. Schoenherr, M.R. Metten and G.K. DeKrey. Univ. of prevents autoimmune diabetes. M. Su, Y. Lin and L. Lai. Northern Colorado. Guizhou Med. Univ., China and Univ. of Connecticut.

33 FRIDAY—POSTER SESSIONS

P1327 68.9 Controlling the residual inflammatory risk in P1335 69.2 Modeling graft-vs-host disease in humanized type 1 diabetic atherosclerosis. M. Yussman, D.H. Wagner, mice using different hematopoietic stem cells sources reveals G. Vaitaitis and D. Waid. Univ. of Colorado Anschutz Med. inherent differences in Tc and myeloid cell biology. N.J. Hess, Campus. P. Hematti and J.E. Gumperz. Univ. of Wisconsin, Madison. P1328 68.10 T regulatory antigen-specific multi-peptide P1336 69.3 CD4+ T cells are both necessary and sufficient immunotherapy induce clinical responses in autoimmune to induce acute graft vs. host disease in lymphopenic diseases. J.P. Marquez-Manriquez, J.A. Matute-Briseno, recipients. B.T. McDaniel, J. Enriquez, K. Furr and P.A.A. Lucero-Diaz and A. Camacho-Hernandez. CICS M. Grisham. Texas Tech Univ. Hlth. Sci. Ctr. USA. P1337 69.4 ITK signaling differentiates GVT and GVHD P1332 68.11 Genetic and pharmacological modulation of after allogeneic bone marrow transplantation by regulating RORa regulates TH17-driven inflammatory disorders. IRF-4, JAK/STAT and eomesodermin expression. L.A. Solt, R. Wang, M. Amir, S. Chaudhari, S. Campbell, M. Karimi. Upstate Med. Univ. M.B. Bassette, A. Eliason, M.S. Sundrud and P1338 69.5 A longitudinal analysis of TCRb repertoire T. Kamenecka. Scripps Res. Inst. diversity in immune tolerance of pediatric patients post- P1321 68.12 IFN-b induces IL-6 production by B cells to UCBT: T cell clonal deletion over clonal anergy. X. Chen promote TH17-mediated neuroinflammation. A.M. Agasing, and P. Szabolcs. Children’s Hosp. of Pittsburgh, Univ. of S. Gawde, N. Siebert, K. Ruprecht, F. Paul and Pittsburgh Med. Ctr. R.C. Axtell. Oklahoma Med. Res. Fndn. and Charite´ – P1339 69.6 Granzyme A-producing helper T cells are Universitatsmedizin¨ Berlin, Germany. critical for lethal acute graft-versus-host disease. P1319 68.13 Human CD39 overexpression or APT102 M.R. Olson, S. Park, B. Griesenauer, P. Mehrpouya- recombinant apyrase administration enhances Treg and Tr1 Bahrami, M. Kazemian, T. Imam, R. Srivastava, T. Hayes, cell immunity in inflammatory bowel disease. M. Vuerich, J. Pardo, S.C. Janga, S. Paczesny and M.H. Kaplan. Purdue R.J. Robles, S. Mukherjee, A. Xie, R. Harshe, A.C. Moss, Univ., Indiana Univ. Sch. of Med. and Univ. of Zaragoza, Spain. S.C. Robson and M.S. Longhi. Beth Israel Deaconess Med. P1340 69.7 Donor Vg4+T cells promote graft-versus- Ctr. leukemia effect and ameliorate acute graft-versus-host P1318 68.14 Anti-CD4/CD8 antibody therapy induces disease in allogeneic hematopoietic stem cell Foxo1 transcriptional activity promoting T cell egress from transplantation. Y. Song, Y. Zhu and H. Liu. National Univ. inflamed tissue during type 1 diabetes. M.P. Clark, of Singapore, Singapore. C. Kroger, A. Martin and R. Tisch. Univ. of North Carolina, P1341 69.8 Bcl-2 inhibition with venetoclax promotes Chapel Hill. induction of mixed chimerism and renal allograft tolerance P1329 68.15 Lipid nanoparticle-mediated delivery of without severe myelosuppression in non-human primates. enhanced costimulation blockade to prevent type 1 T. Kawai, H. Sasaki, D. Ma, A. Dehnadi, A.B. Cosimi, diabetes. Y. Zhang, J. Wang, X. Calderon-Colon, P. Cippa and T. Fehr. Massachusetts Gen. Hosp. and O.N. Tiburzi, M. Iglesias Lozano, J.B. Patrone and Univ. of Zurich, Switzerland. G. Raimondi. Johns Hopkins Univ. P1342 69.9 Inducible nitric oxide synthase-mediated P1330 68.16 ST8Sia6 generated a2,8-disialic acids mitigate inhibition of T cell receptor signaling is a mechanism for hyperglycemia in multiple low dose streptozocin-induced eosinophil dependent amelioration of alloimmunity in lung diabetes. P. Belmonte, M. Shapiro, S. McCue, M. Rajcula grafts. O.O. Onyema, Y. Guo, B. Mahgoub, A. Manafi, and V. Smith Shapiro. Mayo Clin. S. Criswell, J. Lannigan, E.A. Jacobsen, A.E. Gelman, P1326 68.17 Alpha-synuclein acts as an alarmin to promote D. Kreisel and A.S. Krupnick. Univ. of Virginia, Mayo Clin. dendritic cell activation and proinflammatory immune and Washington Univ., St. Louis. response. M.M. Alam, D. Yang, A.L. Trivett, X-Q. Li and P1343 69.10 B7-H4 expression in donor T cells and host J.J. Oppenheim. NCI, NIH. cells negatively regulates acute graft-versus-host disease P1322 68.18 Bivalent anti-CD3 Fab dimers drive T cells into lethality. A. Saha, P.A. Taylor, C.J. Lees, A. Panoskaltsis- a highly efficient fratricide with potential clinical application. Mortari, M.J. Osborn, C.J. Feser, G. Thangavelu, D. Gil Pages, A.D. Nelson, T.A. White and A.G. Schrum. W. Melchinger, Y. Refaeli, G.R. Hill, D.H. Munn, Univ. of Missouri. J.S. Serody, I. Maillard, K. Kreymborg, M. van den Brink, P1333 68.19 Genetic and pharmacological validation of C. Dong, S. Huang, X. Zang, J.P. Allison, R. Zeiser and TAK1 inhibition in macrophages as a therapeutic strategy to B.R. Blazar. Univ. of Minnesota, Univ. Med. Ctr. Freiburg, effectively inhibit TNF secretion. S.A. Scarneo, L. Eibschutz, Germany, Univ. of Colorado, Sch. of Med., Fred Hutchinson P. Hughes and T. Haystead. Duke Univ. Sch. of Med. Cancer Res. Ctr., Georgia Hlth. Sci. Univ., Univ. of North Carolina, Chapel Hill, Univ. of Michigan, Mem. Sloan 69. TRANSPLANTATION IMMUNOLOGY Kettering Cancer Ctr., Abgenix, Fremont, CA, Albert Einstein Col. of Med. and Univ. of Texas MD Anderson Cancer Ctr. Poster Session P1344 69.11 Neutralization of IL-2 prevents acute GVHD FRI. 2:30 PM—EXHIBIT/POSTER HALL while preserving GVL activity via regulating PD-L1/PD-1 signaling. Q. Song, X. Wang, P.J. Martin, Y. Chen and P1334 69.1 FasL-engineered extracellular vesicles block D. Zeng. Beckman Res. Inst., City of Hope, Fred proliferation of alloreactive T cells in vivo. S.S. Yerneni, Hutchinson Cancer Res. Ctr. and Fujian Med. Univ. Union S. Lathwal, P. Shrestha, K. Matyjaszewski, H. Shirwan, Hosp., China. S.R. Das, E.S. Yolcu and P.G. Campbell. Carnegie Mellon Univ. and Univ. of Louisville.

34 FRIDAY—POSTER SESSIONS

P1345 69.12 Alloreactive B cells acquire suppressive P1361 69.28 The prior exposure of CD4+ T cells to function in recipients tolerant to allografts. S. Khiew, D. Yin, alloantigen blunts their secretion of the reparative growth D. Jain, Q. Wang, M-L. Alegre and A.S.F. Chong. Univ. of factor amphiregulin. X. Zhang, L. Mathews and Chicago. H.R. Turnquist. Univ. of Pittsburgh Sch. of Med. P1346 69.13 Inhibition of the Cullin RING E3 ubiquitin ligase P1362 69.29 IL-1b and IL-6 facilitate T cell reconstitution in by MLN4924 targets DEPTOR degradation in Tregs to heart allograft recipients treated with anti-thymocyte globulin. enhance their stability and functional activity. J. Wedel, S. Hasgur, R. Fan, D. Zwick and A. Valujskikh. Cleveland K. Liu and D.M. Briscoe. Boston Children’s Hosp. Clin. P1347 69.14 Kidney allograft recipient absence of P1363 69.30 Profiling pre-existing autoantibodies for myeloperoxidase decreases donor-specific antibody titers prediction of primary graft dysfunction after lung and attenuates antibody-mediated allograft rejection. transplantation. Q. Li, C. Zhu, L. Terada and V. Kaza. R.L. Fairchild, S. Miyairi, N. Dvorina, A. Valujskikh and Univ. of Texas Southwestern Med. Ctr. F W.M. Baldwin. Cleveland Clin. P1364 69.31 The Th17 lineage in heart transplant rejection: R P1348 69.15 Comparison of the suppressive function of examining plasticity and pathogenicity. L.C. Williams and alloantigen-reactive Treg cells and non-stimulated Treg cells J. Iacomini. Sackler Sch. of Grad. Biomed. Sci., Tufts Univ. I in allogeneic skin transplantation. Y-H. Kim and P1365 69.32 The enigmatic impact of donor T cell subsets E.M. Shevach. LISB, NIAID, NIH. on the therapeutic efficacy of tolerogenic protocols for P1349 69.16 p40 Homodimers indirectly induce transplant rejection. M. Iglesias Lozano, D. Bibicheff, endogenous donor-reactive memory CD8 T cell proliferation M. Chicco, G. Brandacher and G. Raimondi. Johns within high-risk allografts via IL-15 signaling. R.L. Fairchild, Hopkins Univ. Sch. of Med. A. Valujskikh and H. Tsuda. Cleveland Clin. P1366 69.33 Type-1 interferons impair the P1350 69.17 Decreased CD4+-Th/CD8+-Tc ratio in bone immunoregulatory activity of IL-10: understanding novel marrow at diagnosis of acute myeloid leukemia predicts mechanisms of abrogation of transplant tolerance. increased risk of graft-versus-host-disease in transplant M. Iglesias Lozano, D. Bibicheff, M. Chicco, patients. W. Wang, H. Li, G. Fan and L. Shen. Oregon G. Brandacher and G. Raimondi. Johns Hopkins Univ. Hlth. and Sci. Univ. and Xinhua Hosp., Shanghai Jiao Tong Sch. of Med. Univ., China. P1367 69.34 Expression of the butyrate/niacin receptor, P1351 69.18 Human immune cells directly recognize GPR109a on T cells plays an important role in a mouse xenogeneic MHCs. M.A. Nouri-Shirazi, H. Katz and model of graft versus host disease. M.D. Docampo, L. Victor. Florida Atlantic Univ. C. Stein-Thoeringer, A. Lazrak, M. Burgos da Silva and P1352 69.19 WITHDRAWN M.R.M. van den Brink. Mem. Sloan Kettering Cancer Ctr. P1353 69.20 Defining the role of graft-infiltrating B cells in P1368 69.35 IL-33 signaling in the barrier tissues sustains the acute rejection of kidney allografts in mice. D. Jain, D. Yin alloimmune responses mediating graft vs. host disease. and A.S. Chong. Univ. of Chicago. G.K. Dwyer, L. Mathews, A. Lucas, B.R. Blazar and P1354 69.21 C3 expression by lung transplants reduces H.R. Turnquist. Univ. of Pittsburgh Sch. of Med. and Univ. alloimmune-mediated injury. H.S. Kulkarni, F. Liao, L. Ma, of Minnesota. X. Wu, D. Kreisel, J.P. Atkinson and A.E. Gelman. P1369 69.36 The effect of mouse cytomegalovirus infection Washington Univ. Sch. of Med. on natural killer cell development following hematopoietic stem P1355 69.22 T cell-mediated bone marrow and splenic cell transplant. C. Dunai, E.G. Aguilar, L.T. Khuat, C.T. Le, hypoplasia in a mouse model of acute graft vs. host Z. Wang, K.M. Stoffel and W.J. Murphy. Univ. of California, disease. J. Enriquez, B. McDaniel Mims, K. Furr and Davis, Univ. of Minnesota and Univ. of California Davis Med. M. Grisham. Texas Tech Univ. Hlth. Sci. Ctr. Ctr. P1356 69.23 Foxp3 cooperates with Ikaros to control the P1370 69.37 Exopolysaccharide from a commensal suppressive function of regulatory T cells. R.M. Thomas, bacterium improves outcome of graft versus host disease by L. Wang, C. Chen, W.W. Hancock and A.D. Wells. decreasing donor T cell activation. O. Kalinina, S. Talley, Children’s Hosp. of Philadelphia. W. Paik, E.M. Campbell and K.L. Knight. Loyola Univ. P1357 69.24 High stearic acid diet aggravates aGVHD by Chicago. promoting Th17 cells through Akkermansia muciniphila. S. Ma, P1371 69.38 Immune responses to the microbiome tune B. Yang, H. Gong, X. Wu and D. Wu. Soochow Univ., China. MHC class II antigen presentation by the intestinal P1358 69.25 Ex vivo fucosylation promotes the GVL effect epithelium to control gut pathology. M. Koyama, of NK cells after allo-HSCT. H. Gong, S. Ma and D. Wu. First P. Mukhopadhyay, I.S. Schuster, A.S. Henden, Affiliated Hosp. of Soochow Univ., China and Soochow Univ., J. Hulsd¨ unker,¨ A. Varelias, M. Vetizou, R.D. Kuns, China. R.J. Robb, P. Zhang, B.R. Blazar, R. Thomas, J. Begun, P1359 69.26 Inhibition of DNA-PK(cs) prevents graft N. Waddell, G. Trinchieri, R. Zeiser, A.D. Clouston, rejection in a murine allograft skin graft study. M. Burdine, M.A. Degli-Esposti and G.R. Hill. Fred Hutchinson Cancer D. Harrison, Z. Waldrip and L. Burdine. Univ. of Arkansas for Res. Ctr., QIMR Berghofer Med. Res. Inst., Monash Univ., Med. Sci. Australia, Freiburg Univ. Med. Ctr., NCI, NIH, Univ. of P1360 69.27 Porcine endogenous retrovirus (PERV) C-free Minnesota, Sch. of Med., Univ. of Queensland, Australia pigs as good candidates for xenotransplantation: absence of and Envoi Pathology. cell-to-cell PERV transmission to humans. Z-Y. Wang, J. Easlick, J. Estrada, L.M. Ryes, G.R. Martens, J.M. Ladowski, E. Gray, M. Tector and J. Tectro. Univ. of We want to hear your thoughts and ideas about Alabama. AAI and its initiatives! Visit us at Booth 1101.

35 FRIDAY—POSTER SESSIONS

P1372 69.39 Human monocytes educated with exosomes P1503 70.4 Adjuvant screen identifies DC modifying from TLR4 primed mesenchymal stem cells treat acute growth factor Flt3 ligand as candidate for prostate cancer radiation syndrome by promoting hematopoietic recovery. DNA vaccine. K. Malo, A.J. Wong, A.H. Thorne, M.H. Forsberg, J. Kink, P. Hematti and C.M. Capitini. L. Humeau and E. Masteller. Inovio Pharmaceuticals, San Univ. of Wisconsin, Madison. Diego. P1373 69.40 Role of Akt isoforms in hyperlipidemia induced P1504 70.5 Carbomer-based adjuvant potentiates CTL changes to regulatory T cells. M. Hyde, J. Bagley and immunity by enhancing cross-presentation of antigens by J. Iacomini. Sackler Sch. of Grad. Biomed. Sci., Tufts Univ. NOX2 and TAP-dependent mechanisms. W. Lee, B. Bakke, P1374 69.41 Graft plasmacytoid dendritic cells improve S. Sonsalla, D. Sanchez, L. Reyes, G. Iyer and M. Suresh. thymic function in allogeneic hematopoietic cell Univ. of Wisconsin, Madison. transplantation. J. Zhu, Y. Wang, A. Ulezko Antonova, P1505 70.6 Kinase domain deleted engineered HER2 Y. Li, C. Giver, M. Hassan and E.K. Waller. Emory Univ. could elicit efficient tumor immune response. I. Jeon, Sch. of Med. and Emory Univ. Hosp. C-H. Koh, T-S. Kang, J-M. Lee, Y. Kang, J. Im, K-S. Shin, P1375 69.42 Inhibiting EZH2 function prevents and treats B. Song and C-Y. Kang. Grad. Sch. of Convergence Sci. and chronic graft vs host disease by disrupting germinal center Technol., Seoul Natl. Univ., South Korea, Res. Inst. of formation and plasma cell maturation. M.C. Zaiken, R. Flynn, Pharmaceutical Sci., Col. of Pharmacy, Seoul Natl. Univ., K. Paz, S. Rhee, P. Park, M. Hemming, P. Sage, A. Sharpe, South Korea and Grad. Sch. of Convergence Sci. and L. Luznik, I. Mailard, G.R. Hill, K. MacDonald, J. Serody, Technol., Seoul Natl. Univ., South Korea. C. Cutler, J. Koreth, D. Miklos, J. Antin, R. Soiffer, J. Ritz, P1506 70.7 Immunotherapy with tumor membrane vesicle- J. Bradner, J. Qi and B.R. Blazar. Univ. of Minnesota, Dana based cancer vaccine inhibits metastatic tumor growth in lung Farber Cancer Inst., Harvard Med. Sch., Brigham and cancer model. R. Bommireddy, H.L. Huang, L.E. Munoz, Women’s Hosp., Harvard Med. Sch., Harvard Med. Sch., A.P. Menon, S. Ramalingam and P. Selvaraj. Emory Univ. Johns Hopkins Univ. Sch. of Med., Univ. of Pennsylvania, Sch. of Med. Fred Hutchinson Cancer Res. Ctr., QIMR Berghofer Med. P1507 70.8 Vasoactive intestinal peptide signaling–a novel Res. Inst., Lineberger Comprehensive Cancer Ctr., Univ. of immune checkpoint in pancreatic ductal adenocarcinoma. North Carolina, Chapel Hill and Stanford Univ. Sch. of Med. S. Ravindranathan, Y. Li, S. Wang, M. Zaidi, P1376 69.43 Vasoactive intestinal polypeptide synthesis by G.B. Lesinski, B. El-Rayes and E.K. Waller. Emory Univ. somatic tissues in transplant recipients limits GVHD in allo- Sch. of Med. BMT. Y. Li and E.K. Waller. Emory Univ. P1508 70.9 Natural adjuvants for in situ vaccination P1377 69.44 Short-term immunosuppression by Ruxolitinib lymphoma immunotherapy. M. Aleynick, P. Peng, promotes the engraftment of hESC-derived RPE cells in a R. Upadhyay, L. Hammerich, V. Roudko, M. Yellin and retinal dege. Y. Gao, Z. Yin, H. Tang, Z. Lu and H. Zhang. J. Brody. Icahn Sch. of Med., Mount Sinai and Celldex Southwest Hosp. Therapeutics. P1378 69.45 Extracellular mitochondria released from P1509 70.10 Selenocompounds mediated upregulation of hepatic ischemia reperfusion induce macrophage activation HLA class I expression enhanced mammaglobin-A peptide- both in vitro and in vivo. Q. Hu, I.D. Haidl, J.S. Marshall and specific cytotoxic T lymphocyte responses against breast I.P.J. Alwayn. Dalhousie Univ. and Leiden Univ. Med. Ctr., cancer cells. V. Tiriveedhi, D. Khandekar and S. Amara. The Netherlands. Tennessee State Univ. and St. Thomas Hosp., Midtown. P1379 69.46 The ocular immune response in a rodent model P1510 70.11 Albumin-Flt3L-induced cross-presenting of whole eye transplantation. B. Li, W. Zhang, Y. Wang, dendritic cells promote neoantigen-specific antitumor T. Banaee, W. Chen, A-J. Su, C. Owens, M. Miller, immunity and subsequent tumor control in murine models of C. Komatsu and K. Washington. Univ. of Colorado cancer. B.K. Lam, D. Esquivel, B. Lee, M. Tan, T.C. Wu and Anschutz Med. Campus and Univ. of Pittsburgh Sch. of Med. C-F. Hung. Johns Hopkins Univ. Sch. of Med. P1511 70.12 Enhancing antigen delivery using spherical 70. ADJUVANT, ANTIGEN PRESENTATION, AND nucleic acids for optimal prostate cancer immunotherapy. PEPTIDE-BASED VACCINES L. Qin, S. Wang, D. Dominguez, A. Long, S. Chen, FOR IMMUNOTHERAPY J. Fan, J.H. Ahn, K. Skakuj, A. Lee, C. Mirkin and B. Zhang. Feinberg Sch. of Med., Northwestern Univ. and Poster Session Northwestern Univ. P1512 70.13 Mass spectroscopy-defined neoepitopes are a FRI. 2:30 PM—EXHIBIT/POSTER HALL rich source of tumor rejection-mediating neoepitopes in a P1500 70.1 Two ICD inducers are better than one for mouse sarcoma. H. Ebrahimi-Nik, T. Shcheglova, induction of anti-tumor immunity in cold carcinomas. J. Michaux, H. Pak, E. Sherafat, S. Al Seesi, I.I. Mandoiu, J.M. Jessup. Inova Schar Cancer Inst. M. Bassani-Sternberg and P.K. Srivastava. Univ. of P1501 70.2 Optimization of the T2 HLA-A2 shift assay for Connecticut, Sch. of Med. and Univ. of Lausanne, Switzerland. testing of the biological activity of immunotherapies. C. Tram, P1513 70.14 Active cancer vaccine targeting carbohydrates O. Hrytsenko and M. Stanford. IMV Inc., Canada. for immunotherapy. V. Padler-Karavani, E.M. Reuven, P1502 70.3 Intradermal DNA Ab42 immunization via S. Leviatan Ben-Arye, H. Yu, R. Duchi, A. Perota, needle-less Jet injection as potential immunotherapy for S. Conchon, J-P. Soulillou, C. Galli and X. Chen. Tel Aviv Alzheimer’s disease. D. Lambracht-Washington, M. Fu Univ., Israel, Univ. of California, Davis, Avantea, Italy and and R.N. Rosenberg. Univ. of Texas Southwestern Med. Ctr. INSERM, France.

36 FRIDAY—POSTER SESSIONS

P1514 70.15 Robust enhancement of tumor-dictated CD8 P1524 71.2 Improving T cell functionality for adoptive T cell T cell trafficking and activation by QS21 adjuvanted vaccine. therapy in metastatic colorectal cancer. S. Ravindranathan, J.K. Sastry, S.M. Nookala, S.M. Dorta-Estremera, G. Sierra M.R. Jajja, A. Waller, R. Bommireddy, P. Selvaraj, L. Yang and A.V. Yanamandra. MD Anderson Cancer Ctr. and Univ. of and E.K. Waller. Emory Univ. Sch. of Med. Texas MD Anderson Cancer Ctr., UTHealth Grad. Sch. of P1525 71.3 Optimization of human T-cell activation and Biomed. Sci. expansion protocols improves efficiency of genetic P1516 70.16 Assessing the impact of neoantigen load on modification and overall cell yield. J. Yu, P. Chen, checkpoint blockade efficacy. Z. Kosaloglu Yalcin, A. Watson, D. Truong, J. Antonchuk, A.I. Kokaji, A. Frentzen, A. Logandha Ramamoorthy Premlal, S.M. Woodside, A.C. Eaves and T.E. Thomas. J. Sidney, J.A. Greenbaum, A. Sette and B. Peters.La STEMCELL Technol., Canada. Jolla Inst. for Immunology. P1526 71.4 IL17 depletion enhances the DNA vaccine P1517 70.17 Induction of immune responses and clinical efficacy in pancreatic ductal adenocarcinoma treatment. F fi ef cacy in a pilot personalized trial of 26 multi-epitope P. Cappello, G. Mucciolo, C. Curcio, C. Roux, R. Curto, R immunotherapy using long peptides Th1 and CD8 G. Barutello and F. Novelli. Univ. of Turin, Italy and Ctr. for simultaneously in progressive tumors. J.P. Marquez- Exp. Res. and Med. Studies, Italy. I Manriquez, J.A. Matute-Briseno, S. Icedo-Zamora, P1527 71.5 A powerful ICOS agonist that enhances anti- A. Durazo-Acuna, P.A. Lucero-Diaz, M.O. Rosas-Delgado tumor immune responses restored by immune checkpoint and A. Camacho-Hernandez. CICS USA. inhibitors. J. Gariepy, A. Prodeus, A. Sparkes, N. Fischer P1515 70.18 Monoclonal antibodies for reducing opioid use and S. Saha. Sunnybrook Res. Inst., Canada, Univ. of Toronto, disorders and overdose. C.A. Baehr and M. Pravetoni. Univ. Canada and McMaster Univ., Canada. of Minnesota. P1528 71.6 A novel agonist of CD137 immune checkpoint P1518 70.19 Defining the signaling and downstream stimulator serves as a cancer immunoprevention agent with regulation of neutrophil-dendritic cell development for efficacy against various tumor types. L. Batra, adjunctive therapy. M. Gui, J.S. Fites, D. Sykes, H.B. Barsoumian, P. Shrestha, J.L. Hawthorne, M.K. Mansour and B.S. Klein. Univ. of Wisconsin, Madison W.S. Bowen, H. Zhao, N.K. Egilmez, J.G. Gomez- and Massachusetts Gen. Hosp. Gutierrez, H. Shirwan and E.S. Yolcu. Inst. for Cellular P1519 70.20 Monocytes outperform ex vivo generated Therapeutics, FasCure Therapeutics, LLC, Department of dendritic cells as cellular vaccines to trigger cytotoxic T Microbiology and Immunology and Hiram C. Polk Jr., MD, lymphocyte responses against cancer in pre-clinical models. Univ. of Louisville. M-N. Huang, L.T. Nicholson, K.A. Batich, D. Kopin, P1529 71.7 Towards identification of a lipid metabolic A.M. Swartz, J.H. Sampson and M.D. Gunn. Duke Univ. checkpoint for immuno-oncology. K-L. Hsu, A.L. Borne, Sch. of Med. J.W. Brulet, S.T. Campbell, C.E. Franks, T. Huang, P1520 70.21 Engineered toxin bodies delivering R.L. McCloud, M. Shin and T.B. Ware. Univ. of Virginia. immunogenic MHC class I peptides to tumor cells summon P1530 71.8 Rejection-resistant off-the-shelf T cells for polyfunctional and relevant CTL responses against cancers. adoptive cell therapy. F. Mo, M. Srinivasan, R. Ma, J.D. Dekker, B. Brieschke, S. LeMar, G.L. Cornelison, T.S. Smith, M.K. McKenna, E. Atilla, P. Ataca Atilla, A. Iberg, G.L. Robinson, S. Chu, E.K. Willert and H.E. Heslop, M.K. Brenner and M. Mamonkin. Baylor Col. H.J. Ramos. Molec. Templates. of Med. P1521 70.22 RNA origami nanostructures for potent and P1531 71.9 Modulating interlukin-7 (IL-7) cytokine receptor safe anti-cancer immunotherapy. L. Matiski, X. Qi, X. Liu, signaling to enhance the persistence and anti-tumor efficacy of R. Rodriguez del Villar, F. Zhang, H. Yan and Y. Chang. Sch. Epstein-Barr virus (EBV)-specific T cells in EBV-positive of Molec. Sci., Arizona State Univ. and Sch. of Life Sci., Arizona malignancies. S. Sharma, T. Shum, K. Parikh, B. Omer State Univ. and C. Rooney. Baylor Col. of Med. and Houston Methodist P1522 70.23 A novel vaccination platform for epicutaneous Res. Inst. allergen-specific immunotherapy based on beta-glucan P1532 71.10 DeepTM IL-12 priming enhances tumor-specific neoglycoconjugates. E. Korotchenko, Y. Machado, T cell efficacy and inflammatory activity in tumors without H. Strandt, I. Joubert, V. Schiessl, R. Bauer, M. Sarajlic, eliciting systemic toxicities. K. Sauer, D-K. Chang, T. Neuper, S. Wildner, U. Horejs-Hoeck, G. Gadermaier, G. Ahmad, J. Nardozzi, K. Sackton, J. Lyons, S. Scheiblhofer, J. Thalhamer and R. Weiss. Univ. of T. Andresen and D. Jones. Torque Therapeutics. Salzburg, Austria and Univ. of British Columbia, Canada. P1533 71.11 Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell- 71. CYTOKINE AND T CELL-BASED delivered murine leukemia model. A. Berger, S. Colpitts, IMMUNOTHERAPY M. Seabrook, C. Furlonger, M. Bendix, J. Moreau, W. McKillop, J. Medin and C.J. Paige. Ontario Cancer Poster Session Inst., Canada and Med. Col. of Wisconsin. FRI. 2:30 PM—EXHIBIT/POSTER HALL P1534 71.12 Lenolidamide and IL-15 enhance natural killer cell-mediated immunity and augments the anti-tumor effect of P1523 71.1 Regional pressure-enabled drug delivery of an anti-CD30/CD16A bispecific antibody against Hodgkin’s anti-PD-1 agent for colorectal liver metastases improves lymphoma B-cells. A. Manna, S. Aulakh, S. Ailawadhi, anti-tumor activity without increased hepatic toxicity. A. Chanan- Khan, T. Sher and A. Paulus. Mayo Clin. L.F. Chai, J.C. Hardaway, M.C. Lopes, B.A. Rabinowitz, P. Guha, D. Jaroch, B. Cox, N.J. Espat and S.C. Katz. Roger Williams Med. Ctr. and TriSalus Life Sciences, Inc.

37 FRIDAY—POSTER SESSIONS

P1535 71.13 CD38hi B-regulatory cells maintain P1546 72.3 A replicating adenovirus-SIV recombinant pathological immune tolerance in chronic lymphocytic prime/protein boost regimen induces SIV-specific T and B leukemia/B cell diseases: Potential therapeutic cell responses in lymph nodes associated with humoral considerations. A. Manna, S. Aulakh, T. Sher, immunity in the genital mucosa of female rhesus macaques. S. Ailawadhi, A. Chanan- Khan and A. Paulus. Mayo Clin. S.H. Hait, C.J. Hogge, Z. Mushtaq, T. Hoang and M. Robert- P1536 71.14 Unbiased functional identification and Guroff. NCI, NIH. therapeutic targeting of T cell neoantigens in a spontaneous P1555 72.4 Novel HIV DNA vaccine changes the immune murine squamous cell carcinoma. J.S. Dolina, J. Lee, hierarchy and elicits broad cytotoxic T cell responses targeting B. Peters and S.P. Schoenberger. La Jolla Inst. for subdominant viral epitopes. B.K. Felber, Z. Lu, X. Hu, Immunology. A. Valentin, M. Rosati, J.I. Mullins and G.N. Pavlakis. P1537 71.15 Determinants of TCRa-b chain pairing in Natl. Cancer Inst. and Univ. of Washington. generating TCR diversity. H. Tanno, T.M. Gould, P1547 72.5 Influence of vaccine-induced mucosal NKp44+ R.E. Durrett, J.R. McDaniel, W. Cao, J. Gollihar, and mucosal NKp44-NKG2A- cells on SIV-infection outcomes C. Steven, Y. Tanno, A.D. Ellington, G.C. Ippolito, in rhesus macaques. M.A. Rahman, E. Ko, G. Enyindah- W. Hildebrand, G. Georgiou and J.J. Goronzy. The Univ. Asonye, S.H. Hait, T. Hoang and M. Robert-Guroff. NCI, of Texas at Austin, Stanford Univ. Sch. of Med. and The Univ. NIH. of Oklahoma Hlth. Sci. Ctr. P1549 72.6 Passive infusion of Fc-modified neutralizing P1538 71.16 A novel preclinical immunocompetent CAR antibodies does not affect the dynamics of plasma virus T cell mouse model for solid tumors. P.M. Sullivan, decay in SHIV-infected macaques. M. Asokan, L. Arguedas-Jimenez, A. Johnson, J. Yokoyama, A. Maximova, J. Dias, A.R. Crowley, A. Pegu, Y. Yuzefpolskiy, M. Jensen, V. Kalia and S. Sarkar. D. Ambrozak, K. McKee, W. Shi, J-P. Todd, Seattle Children’s Res. Inst. and Univ. of Washington. M.E. Ackerman, L. Gama, B.F. Keele, J.D. Lifson, P1539 71.17 Use of small molecule inhibitors of metabolism A.S. Perelson, J.R. Mascola and R. Koup. NIAID, NIH, to enhance T cell proliferation and phenotype for adoptive T cell Geisel Sch. of Med., Dartmouth Col., Frederick Natl. Lab. therapies. A.L. Waller, C.R. Funk, S. Ravindranathan and and Los Alamos Natl. Lab. E.K. Waller. Emory Univ. P1552 72.7 Antibody cross-reactivity in chronic HIV/HCV P1540 71.18 Covalent adaptor synNotch and chimeric co-infection. K. Pilewski, I. Setliff, S. Kalams and antigen receptors for programmable antigen targeting. I. Georgiev. Vanderbilt Univ. Med. Ctr. J.J. Lomueller, A. Butchy, Y. Tivon, M. Kvorjak, P1550 72.8 Reprogramming the antigen specificity of B N. Miskov-Zivanov, A. Deiters and O.J. Finn. Univ. of cells using genome-editing technologies. A. Gonzalez- Pittsburgh. Martin, R. Andrabi, R.P. Fuller, B. Murrell, L.E. McCoy, P1541 71.19 Improving immunotherapy through immune K. Porter, D. Huang, W. Li, D. Sok, K. Le, B. Briney, checkpoint assays, CAR-T target display, and effector M. Chateau, G. Rogers, L. Hangartner, A.J. Feeney, function optimization. S. Edgcomb, J. Zhu, Z. Tao, M. Hsu, D. Nemazee, P. Cannon, D. Burton and J.E. Voss. M. Kimbara, S. Oberle and H. Zhu. BPS Bioscience. Autonoma Univ. of Madrid and Inst. for Biomedical Res. P1542 71.20 CD4-directed adoptive immunotherapy of Alberto Sols, Scripps Res. Inst., Univ. of California, San chimeric antigen receptor-modified T cells with inducible Diego, Univ. Col. London, United Kingdom, Scripps Ctr. for caspase-9 gene for CD4 T-cell malignancies. W. Ma, G. Li, HIV/AIDS Vaccine Immunology & Immunogen Discovery and D. Tian, L. Su and X-n. Xu. Imperial Col., United Kingdom, Univ. of Southern California Keck Sch. of Med. UNC-CH, Beijing Ditan Hosp., China and Univ. of North P1556 72.9 Characterization of heterologous HIV-1 Tier 2 Carolina, Chapel Hill. neutralizing mAbs cloned from a macaque immunized with viral quasispecies present in a human subject with neutralization 72. HIV/SIV VACCINE/IMMUNOTHERAPY AND breadth. D.A. Spencer, D.C. Malherbe, H. Henderson, ` IMPACT OF HIV/SIV INFECTION IN S. Pandy, N.V. Bernat, M. Adori, B. Goldberg, ANTIGEN-SPECIFIC IMMUNITY N. Dambrauskas, W. Sutton, N. Sather, J. Kobie, M.E. Ackerman, G.B. Karlsson Hedestam, N.L. Haigwood Poster Session and A. Jones Hessell. Oregon Hlth. and Sci. Univ., Karolinska Inst., Karolinska Inst., Sweden, Geisel Sch. of Med., Dartmouth FRI. 2:30 PM—EXHIBIT/POSTER HALL Col., Seattle Children’s Res. Inst. and Univ. of Rochester Med. P1548 72.1 HIV-1-specific B cell immune responses in Ctr. rhesus macaques induced by early region deleted-Ad5 P1543 72.10 Impact of gut microbiota on vaccine response vectors. K. Sangare, C. Hogge, S. Helmold Hait, in HIV exposed infants. D.D. Nyangahu, C. Plumlee, T. Hoang, M. Robert-Guroff and M.A. Thomas. Howard J. Wendoh, K.B. Urdahl and H. Jaspan. Seattle Children’s Univ. and NCI, NIH. Res. Inst., Univ. of Cape Town, South Africa and Univ. of P1551 72.2 Replicating Ad-SIV recombinant vaccines elicit Washington. mucosal humoral immunity in rhesus macaques at both rectal and vaginal sites with potential protective efficacy. C.J. Hogge, S.H. Hait, G. Enyindah-Asonye, Z. Mushtaq, T. Hoang and M. Robert-Guroff. NCI, NIH. Don't forget to take advantage of the knowledge-building opportunities presented at the Exhibitor Workshops. Check the Meeting Guide or app for more details.

38 FRIDAY—POSTER SESSIONS

P1544 72.11 Higher PIK3C2B gene expression of H1N1+ P1564 73.8 Segregation of chicken MHC-Y haplotypes in specific B cells is associated with lower H1N1 high and low antibody selected lines provides evidence that immunogenicity after trivalent influenza vaccination in MHC-Y contributes to the genetics of immune responses. perinatally HIV infected children. N. Cotugno, S. Zicari, J. Zhang, R.M. Goto, C.F. Honaker, P.B. Siegel and E. Morrocchi, L.R. De Armas, S. Pallikkuth, S. Rinaldi, M.M. Miller. Beckman Res. Inst., City of Hope and Virginia S. Rocca, E.C. Manno, P. Zangari, S.F. Andrews, Polytechnic Instit. and State Univ. A. Cagigi, P. Rossi, A.B. McDermott, S. Pahwa and P1557 73.9 Sex-specific DLA class II haplotypes are P. Palma. Children’s Hosp., Italy, Univ. of Rome, Tor associated with primary hypoadrenocorticism in Standard Vergata, Italy, Univ. of Miami and VRC, NIAID, NIH. Poodle dogs. A. Treeful, A. Rendahl and S. Friedenberg. P1545 72.12 Impact of HIV-1 infection and antigen class on Univ. of Minnesota. T follicular helper cell responses to pneumococcal P1561 73.10 Teriflunomide prevents the activation-induced polysaccharide-protein conjugate vaccine. L.K. Nicholson. CD25 expression on canine CD4+ T cells. A. Jasiecka- F Denver Veterans Affair Med. Ctr. Mikolajczyk, P. Socha, J.J. Jaroszewski and R P1553 72.13 Recombinant human IL-15 in combination with T. Maslanka´ . Univ. of Warmia and Mazury, Olsztyn, Poland. anti-PD-L1 (Avelumab) in SIV infected rhesus macaques leads P1563 73.11 Weaning and postnatal age influence the early I to the expansion of a subset of CXCR3+PD1-/low CD8 T cells. time course and nature of intestinal mast cell activation and M. Moussa, J. Cheng, P. Chen, H. Chen, T. Li, J. Qin, mucosal inflammation in a porcine model of early life adversity. J.D. Lifson, M.C. Sneller, L. Krymskaya, S. Godin, N. Wilson, Y. Li, M. Rajput, K. Thelen, K. Kerr and C. Lane and M. Catalfamo. Georgetown Univ. Sch. of A.J. Moeser. Michigan State Univ. Med., NIH, NIAID, NIH, Leidos Biomed. Res., Inc. and P1568 73.12 Newly isolated porcine epidemic diarrhea virus Smithers Avanza Toxicology Services. resistance to interferon and neutralizing antibody. H-J. Shin P1554 72.14 Assessing the in-vitro effects of anti-PD-L1 and J-E. Park. Chungnam Natl. Univ., South Korea. (Avelumab) and recombinant human rhIL-15 in CD8 T cell P1571 73.13 Low weight piglets show differences in function from HIV infected patients. B. Goshu, C. Lane and intestinal microbiota, intestinal transcriptome and immune M. Catalfamo. NIAID, NIH and Georgetown Univ. Sch. of Med. cell profile compared to high weight piglets during the first two weeks of lactation. M. Blais, B. Morissette, G. Talbot, 73. VETERINARY AND F. Beaudoin, K. Deschene, L. Lo Verso, N. Bissonnette, COMPARATIVE IMMUNOLOGY K. Lauzon, F. Guay and M. Lessard. Agr. and Agri-Food Canada, Canada and Univ. Laval, Canada. Poster Session P1573 73.14 Skin recirculating B cell subsets in a model of FRI. 2:30 PM—EXHIBIT/POSTER HALL lymph cannulation in sheep. J. Hunka, J.T. Riley and G.F. Debes. Thomas Jefferson Univ. P1577 73.1 Evolution of the AID/APOBEC family of P1575 73.15 Non-therapeutic administration of antimicrobial cytidine deaminases in lampreys. M. Hirano, Y. Sutoh, growth promoters to interrogate suppression mechanisms of S. Das and M. Cooper. Emory Univ. Sch. of Med. innate and adaptive immune responses using an ovine model P1565 73.2 On the evolutionary origins of Cd1d and the of stress. S.T. Clarke and G.D. Inglis. Univ. of Alberta, type I, semi-invariant natural killer T cells. N.C. Suryadevara, Canada and Lethbridge Res and Develop. Ctr. A. Kumar, P. Chimski, K. Oh, C. Caster, R.R. Truman, P1559 73.16 Characterization of bovine gd T cells L. Ren, M. Criscitiello and S. Joyce. Vanderbilt Univ. Med. phenotype following Mycobacterium bovis vaccination or ’ Ctr., Texas A&M Univ., Natl. Hansen s Dis. Program, Lab. Res. virulent infection. M. Guerra-Maupome, M.V. Palmer, Branch, Louisiana State Univ. and State Key Lab. of Agro- R. Waters and J.L. McGill. Iowa State Univ. and USDA- biotechnology, China Agricultural Univ. ARS, Natl. Animal Dis. Ctr. P1572 73.3 Somatic hypermutation of T cell receptor P1558 73.17 Disease tolerance and immune response in gamma, delta, and beta chains in nurse sharks. J.A. Ott, bovine trypanosomiasis is mediated by CD14 promoter J. Harrison, Y. Ota, M.F. Flajnik and M.F. Criscitiello. gene. O. Morenikeji and B. Thomas. Rochester Instit. of Texas A&M Univ. and Univ. of Maryland Sch. of Med. Technol. P1576 73.4 Isolation and characterization of acute phase P1560 73.18 Aerosol vaccination with Bacille Calmette- protein C-reactive protein in shark serum: a potential biomarker Guerin induces a trained innate immune phenotype in for assessing health in wild sharks. S.M. Orndorff and calves. M. Guerra-Maupome and J.L. McGill. Iowa State L. Merly. Univ. of Miami. Univ. P1562 73.5 Rainbow trout as a model for the study of P1569 73.19 Equine bone marrow mesenchymal stromal neuroimmune interactions in the nasal mucosa. I. Salinas, cells inhibit reactive oxygen species production by A. Sepahi, A. Kraus and P. Das. Univ. of New Mexico. neutrophils without affecting other important microbicidal fl P1566 73.6 In ammatory changes and melanization in the functions. C. Henriquez, G. Espinosa, A. Schenffeldt, Atlantic salmon (Salmo salar) targeted by in situ hybridization. P. Alarcon, G. Gajardo, A. Plaza, V. Caffi, B. Uberti and H. Bjoergen, I. Hordvik and E.O. Koppang. NMBU, Norway G. Moran. Univ. Austral de Chile, Chile. and UIB, Norway. P1574 73.20 T cells responses during resolving hepacivirus P1567 73.7 The melanomacrophage center is a potential A infection, a surrogate animal model for human hepatitis C. evolutionary precursor to the mammalian germinal center. F. Gimenez, R.H. Mealey and J.D. Ramsay. Washington N.C. Steinel. Univ. of Massachusetts, Lowell. State Univ., Col. of Vet. Med.

39 FRIDAY—POSTER SESSIONS

P1570 73.21 Functional comparison of human and non- P1603 74.10 Sphingosine 1-phosphate lyase promotes the human primate neutrophil responses. J.F. Brinkworth, type I interferon-mediated innate immune response to K. Van Etten, P. Bhatt, K. McClure, N. Valizadegan, influenza but is subjected to degradation by influenza A M. Woo, S. Gunasekera, Y. Suarez and B. Aldridge. Univ. virus NS1. J.J. Wolf, C. Xia, M. Vijayan, Y. Song, of Illinois, Urbana-Champaign. C.J. Studstill, H. Ngo, M.C. Johnson, J.D. Saba, P1578 73.22 Transcriptome analysis of distinct coelomocyte S. Alexander and B. Hahm. Univ. of Missouri, Columbia populations in Strongylocentrotus purpuratus. S.D. Fugmann, and Univ. of California, San Francisco. J.F. Cheng and H.H. Huang. Chang Gung Univ., Taiwan. P1610 74.11 The nonlinear relations that predict influenza P1579 73.23 Annotation of the WC1 gene family in Sus viral dynamics, host response, pathology, and disease scrofa and evaluation of individual SRCR domain affinity for severity. A.M. Smith. The Univ. of Tennessee Hlth. Sci. Ctr. Mycobacterium bovis and Leptospira spp. L.A. Le Page, P1606 74.12 WITHDRAWN J. Buck, N. Boisvert, A. Gillespie, A. Yirsaw, P1611 74.13 Evaluation of epitope specificity in the immune E. Hudgens, H. Hsu, C.L. Baldwin and J.C. Telfer. Univ. response to PR8 H1N1 influenza virus infection in neonatal of Massachusetts, Amherst, Harvard Med. Sch., The Ohio and adult African green monkeys. E.A. Clemens, D. Angeletti, State Univ., Col. of Vet. Med., Univ. of Massachusetts B.C. Holbrook, S.T. Aycock, J.W. Yewdell and Amherst and Univ. of Maryland Sch. of Med. M.A. Alexander-Miller. Wake Forest Sch. of Med., Univ. of Gothenburg, Sweden, Univ. of Tennessee Hlth. Sci. Ctr. and 74. INFLUENZA VIRUS AND THE NIAID, NIH. IMMUNE RESPONSE P1602 74.14 Influenza virus M1 interacts with SLD5 to block host cell cycle and inhibit lung epithelial regeneration. M. Fang, Poster Session L. Zhu and W. Zhao. Inst. of Microbiology, CAS, China. fl FRI. 2:30 PM—EXHIBIT/POSTER HALL P1614 74.15 The immune responses to in uenza vaccine in aged and metabolic disease occurred cynomolgus macaques. P1604 74.1 CD8+ T cells require IL-27R for optimal E. Urano, Y. Murakata, T. Okamura and Y. Yasutomi. Natl. fl generation of an effector response during in uenza infection. Institutes of Biomed. Innovation, Hlth. and Nutrition, Japan. P. Dunbar, Z-R.T. Li, J. Lobby, S.L. Hayward, L. Lawrence and J.E. Kohlmeier. Emory Univ. Sch. of Med. 75. VIRUSES AND INNATE IMMUNE EFFECTORS P1608 74.2 CD4 cell-derived IL-2 synergizes with influenza infection to exacerbate lung inflammation. T.M. Strutt and Poster Session A. Gilchrist. Univ. of Central Florida. FRI. 2:30 PM—EXHIBIT/POSTER HALL P1605 74.3 IFN-lambda modulates dendritic cells to facilitate protective T cell immunity during influenza A virus P1625 75.1 Plasmacytoid dendritic cells contribute to HIV infection. E.A. Hemann, R. Green, B. Turnbull, diseases and viral persistence via IDO-dependent R.A. Langlois, R. Savan and M. Gale. Univ. of Washington mechanisms. G. Li, J. Ma, H. Yu, W. Bi, Y. Wu, L. Cheng and Univ. of Minnesota. and L. Su. UNC-CH and Inst. of Biophysics of Chinese Acad. P1609 74.4 Concomitant effector and LAG-3 regulatory of Sci., China. responses of Th1-committed cells in acute influenza. P1623 75.2 Microglia secrete exosomes during persistent A. Dutta, C-T. Huang, C-Y. Hung, T-C. Chen, C-Y. Lin, virus infection of the central nervous system that promote Y-C. Lin, C-S. Chang, T-A. Chen and Y-L. Huang. Chang demyelinating disease. J.K. Olson and N. Luong. Univ. of Gung Mem. Hosp., Taiwan. Minnesota. P1600 74.5 BCL6 modulates tissue neutrophil survival and P1627 75.3 A novel proviral function for IL-17 during exacerbates pulmonary inflammation following influenza gammaherpesvirus infection. C.N. Jondle, K.E. Johnson, infection. J. Sun and B. Zhu. Mayo Clin. C.A. Aurubin, G. Xin, W. Cui, A. Huppler and P1612 74.6 Autoreactive potential of universal influenza V.L. Tarakanova. Med. Col. of Wisconsin and Blood Res. Inst. vaccines. M.A. McGargill, M.R. Pillai, T-C. Chang, P1617 75.4 IL-33 promotes antiviral immunity and protects J. Crawford, R. Keating, J. Labombarde, C. Lewis, against congenital Zika disease in mice. Y. Liang, J. Escano J. Guthmiller, Q-Z. Li, P.C. Wilson and P. Thomas. St. and J. Sun. Univ. of Texas Med. Br. Jude Children’s Res. Hosp., The Univ. of Chicago and Univ. P1629 75.5 IL-36g regulates neutrophil infiltration and of Texas Southwestern Med. Ctr. limits neuroinvasion in genital HSV-2 pathogenesis. P1613 74.7 Influenza A virus (IAV) infection in humans J.K. Gardner and M.M. Herbst-Kralovetz. Univ. of Arizona. leads to expansion of highly diverse CD8 T cell repertoires P1633 75.6 Cell type-specific sensing of murine cross-reactive with Epstein Barr virus. A. Gil, R. Mishra, cytomegalovirus through MyD88 and STING control virus I.Y. Song, N. Aslan, D. Ghersi and L.K. Selin. Univ. of infection. S.J. Piersma, J. Poursine-Laurent, L. Yang, Massachusetts Med. Sch. and Univ. of Nebraska. B.A. Parikh and W.M. Yokoyama. Washington Univ. in P1607 74.8 Mechanism of influenza virus-induced St. Louis and Washington Univ. in St. Louis. inflammatory cell death. K. Sannula and T-D. Kanneganti. P1624 75.7 The innate signaling adaptor MAVS regulates St. Jude Children’s Res. Hosp. the quality of the antibody response to West Nile virus. P1601 74.9 Differential effect of GITR on lung effector T cell D. Schenten, M. O’Ketch, C. Larson and B. Hall. Univ. of subpopulations during influenza infection. K.L. Chu, Arizona. N.V. Batista and T.H. Watts. Univ. of Toronto, Canada. P1630 75.8 IFN-I blockade improves the immunogenicity of viral vector vaccines. N.M. Palacio, T. Dangui, Y. Wang and P.A. Penaloza-MacMaster. Feinberg Sch. of Med., Northwestern Univ. and Northwestern Univ.

40 FRIDAY—POSTER SESSIONS

P1626 75.9 Not just acute: IRF-7 plays a key role in P1636 75.23 Serum IL-6 level may differentiate immune restriction of chronic gammaherpesvirus infection. inactive phase from other phases in patients with chronic K.E. Johnson, C.N. Jondle, P.T. Lange, C.A. Aurubin and hepatitis B virus infection. H.W. Lee, I.S. Oh, H.Y. Chang, V.L. Tarakanova. Med. Col. of Wisconsin. J.I. Lee and J.S. Lee. Yonsei Univ. Col. of Med., South Korea P1616 75.10 A high throughput genetic screen to uncover and Natl. Police Hosp. novel antiviral mechanisms of the interferon system. P1638 75.24 Innate immune responses to Rift Valley fever S. Chattopadhyay, G. Subramanian, A. Glanz, K. Chawla, virus in the brain. D.R. Weilhammer, F. Bourguet, J. Gartland and B. Jay. Univ. of Toledo. K. Sanchez, A. Phillips, A. Sebastian and N. Hum. P1621 75.11 A comprehensive map of the human dendritic Lawrence Livermore Natl. Lab. cell HIV-response transcriptional network. J.S. Johnson, P1639 75.25 CD5+ B-1 cell responses to infection are facilitated N. De Veaux, A.W. Rives, X. Lahaye, S.Y. Lucas, by toll-like receptor stimulation. F.L. Smith, H.P. Savage, B. Perot,´ M. Luka, L.M. Amon, A. Watters, A. Aderem, K. Klasener,¨ M. Reth and N. Baumgarth. Univ. of California, F N. Manel, D.R. Littman, R. Bonneau and M.M. Menager´ . Davis, Max Planck Inst. for Immunobiology and Epigenetics, R Univ. of Utah, Simons Fndn., INSERM U932, France, Ctr. for Germany and Univ. of Freiburg, Germany. Infectious Dis. Res., INSERM UMR 1163, France and New I York Univ. Sch. of Med. 76. VIRUSES, CD8+ T CELLS, AND P1631 75.12 Profiling soluble immune checkpoint proteins NATURAL KILLERS in the peripheral blood and central nervous system of HIV patients. Y. Xia, W. Li, J. Yang, G. Sun, J. Lan, X. Zheng and Poster Session Q. Yu. Indiana Univ. Sch. of Med. and Wenzhou Med. Univ. FRI. 2:30 PM—EXHIBIT/POSTER HALL P1615 75.13 Severe fever with thrombocytopenia syndrome virus infection drives macrophage differentiation skewed to M2 P1668 76.1 Regulation of antiviral CD8 T cell immunity by phenotype which is regulated by miR-146. I. zhang. Nanjing CD352/SLAMF6: from patterns to pathways. V. van der Heide Univ., China. and D. Homann. Icahn Sch. of Med., Mount Sinai. P1618 75.14 Regulation of IL-37 and its signaling co- P1674 76.2 Activation of microglia in CD8 T cell-initiated ’ receptor IL-1R8 in HIV infection. A. Ahmad, S. Samarani, blood-brain barrier disruption induced during Theiler s virus fi A. Abulkhir and D. Amre. Sainte-Justine Univ. Hosp., infection. R. Khadka, J. Zheng, K. Ayasou , F. Jin, Z. Trtiz, Canada. L. Wu and A. Johnson. Mayo Clin., Grad. Sch. of Biomed. Sci. P1622 75.15 WITHDRAWN P1663 76.3 Cytomegalovirus infection drives avidity P1628 75.16 Regulation and perturbation of myocyte selection of natural killer cells. N.M. Adams, D. Lumaquin, enhancer factor-2 activity in adult T-cell leukemia/lymphoma. E.K. Santosa, B.M. Whitlock, B.T. Jackson, J.B. Le Luduec, K.K. Madugula, C. DeMarino, A. Panfil, A. Dobzanki, R. Sottile, O.E. Weizman, M. Huse, K.C. Hsu and J.C. Sun. R. Ginwala, Z. Khan, F. Kashanchi, I. Lemasson, Mem. Sloan Kettering Cancer Ctr. fi P. Green, E. Harhaj and P. Jain. Drexel Univ. Col. of Med., P1664 76.4 Single-cell cloning of untreated HIV-speci c George Mason Univ., Ohio State Univ., East Carolina Univ. and natural killer cells in humans. O.A. Lucar, J. Ghofrani, Pennsylvania State Univ. P.A. Goepfert, S. Jost and R.K. Reeves. Harvard Med. P1634 75.17 HIV infection induces CD44+PD-L1+ tumor Sch. and Univ. of Alabama, Birmingham. initiating cells in AIDS associated non-AIDS defining P1665 76.5 The Ly49G2 inhibitory receptor is essential to cancers. H.B. Gupta, X. Zhang, T.J. Curiel and MHC I-dependent NK cell control of murine cytomegalovirus S. Kulkarni. Univ. of Texas Hlth. Sci. Ctr. San Antonio and infection. J.M. Cronk, A. Gamache, A. Gillespie and Texas Biomed. Res. Inst. M.G. Brown. Univ. of Virginia. P1637 75.18 Patrolling ILCs restrain mucosal viral P1671 76.6 Accumulation of CXCR5+ NK cells during replication through tissue-wide delivery of IFN-g. chronic SHIV infection is associated with enhanced viral J.P. Shannon, G.V. Reynoso, O. Kamenyeva, control. V. Velu, S.A. Rahman, J.M. Billingsley, D.T. McManus and H.D. Hickman. NIAID, NIH. C.C. Ibegbu, A. Shiferaw, F.J. Villinger, S. Bosinger, P1619 75.19 Robust local immune response to vaccination P. Johnson, R.R. Amara and V. Velu. Emory Univ., Univ. with a live-attenuated HSV-1 strain (HSV-1 0DNLS) is delayed of Louisiana Lafayette and Yerkes Primate Res. Ctr. and in mice vaccinated with the parental live virus. D.J.J. Carr and Emory Vaccine Ctr. G. Gmyrek. Univ. of Oklahoma Hlth. Sci. Ctr. P1676 76.7 LAG-3 modulation of natural killer cell P1620 75.20 Interferon-a producing dendritic cells impair immunoregulatory function. A. Ali, M.T. Moran, J. Tuazon, viremia control in simian immunodeficiency virus-infected I. Gyurova, D.A.A. Vignali and S.N. Waggoner. Cincinnati ’ rhesus macaques. E. Ko, S.H. Hait, M.A. Rahman, Children s Hosp. Med. Ctr., Univ. of Cincinnati and Univ. of G. Enyindah-Asonye, C.J. Hogge, T. Hoang and Pittsburgh Sch. of Med. fi “ ” M. Robert-Guroff. NCI, NIH. P1675 76.8 IL-18 de nes exclusive memory-like NK cell P1632 75.21 Fibroblasts from individuals with trisomy 21 populations. R.R. Anderko, C.R. Rinaldo and R.B. Mailliard. have increased type-I interferon responses to HSV-1 Univ. of Pittsburgh Grad. Sch. of Publ. Hlth. compared to typical adults. K. Royzman, C. Drews, P1669 76.9 MicroRNA-21 is a critical regulator of the T. Maxwell, G. Singh, C. Keefe and S. James. Regis Univ. antiviral NK cell response. C. Geary, C. Lau, C. Zawislak, P1635 75.22 D42PD-1 enhances HIV replication and E.K. Santosa, M. Berrien-Elliott, N. Bezman, L.L. Lanier, suppresses maturation of dendritic cells. R. Zhou, Y. Mo, T.A. Fehniger and Y.C-Y. Sun. Mem. Sloan Kettering Cancer D. Zhou and Z. Chen. Univ. of Hong Kong. Ctr., Washington Univ. in St. Louis and Univ. of California, San Francisco.

41 FRIDAY—POSTER SESSIONS

P1673 76.10 Dynamics of adaptive natural killer cells in P1678 76.14 Quantifying the selection on influenza A virus longitudinal analysis of CMV vaccine recipients. imposed by CD8 T cells. Z-R.T. Li, V.I. Zarnitsyna, I.E. Gyurova, H. Schlums, D. Bernstein, Y. Bryceson and A.C. Lowen, J.E. Kohlmeier and R. Antia. Emory Univ. S.N. Waggoner. Cincinnati Children’s Hosp. Med. Ctr. and and Emory Univ. Sch. of Med. Karolinska Inst., Sweden. P1672 76.15 Spatial analysis of CD8+ T cell activation after P1677 76.11 The epigenetic profile of CD8+ T cells during local viral replication in the skin. C.S. Malo, G.V. Reynoso and SIV infection. S.T. Pillay, M. Nag, J.E. Fogle and K. De Paris. H.D. Hickman. NIAD, NIH. UNC-CH, NCI, NIH and North Carolina State Univ. Col. of Vet. P1662 76.16 Patients with natural killer (NK) cell chronic Med. active Epstein-Barr virus have a unique phenotype, with P1667 76.12 Crosseactivity of flaviviruses specific CD8+ increased activation of the PI3K/Akt/mTOR and STAT1 T cell responses across different viral species. A. Grifoni, pathways and immature NK cells. KC. Dowdell. NIAID, NIH. H. Voic, J. Sidney, A.D. de Silva, A. Durbin, S.A. Diehl, P1666 76.17 Protein kinase C-eta is dispensable for the E. Harris, A. Sette and D. Weiskopf. La Jolla Inst. for activation and function of CD8+T cells. H.Y. Liu, C. Pedros, Immunology, Johns Hopkins Univ. Bloomberg Sch. of Public A.J. Canonigo-Balancio and A. Altman. La Jolla Inst. for Hlth., Univ. of Vermont, Sch. of Med. and Sch. of Public Hlth., Immunology. Univ. of California, Berkeley. P1679 76.18 Investigating the immunological role of P1670 76.13 Diets rich in omega-3s decrease CD8 T cell 2- galectin-9 on natural killer (NK) cells in human dimensional affinity and short-lived effector cell development immunodeficiency virus (HIV). M. Motamedi and S. Elahi. and function during viral infection. E.M. Kolawole and Univ. of Alberta, Canada. B.D. Evavold. Univ. of Utah Sch. of Med.

42 SATURDAY—AM SATURDAY MORNING

MAY 11

77. MAJOR SYMPOSIUM C: ACUTE AND CHRONIC 8:24 Cure chronic HBV infection via targeting adaptive INFLAMMATION immune response: a critical role of CD4+ T cells. M.-H. Tao. Academia Sinica, Taiwan. Major Symposium 8:48 Biodegradable nanoparticle co-encapsulating peptides SAT. 8:00 AM—BALLROOM 20D and CpG elicits protective T cell immunity against lethal influenza viral infection. H.-C. Yang. Natl. CHAIRS: C. KEMPER, M.C. CARROLL Taiwan Univ. Hosp. 8:00 An unexpected key role for the complosome in cell 9:12 New method for the development of glycoconjugate metabolism. C. Kemper. NHLBI, NIH. bacterial vaccines using bacteriophages. C.-Y. Wu. 8:35 Functional importance of allelic differences in human Academia Sinica, Taiwan. S complement C4A and C4B and inflammatory 9:36 MAP4K family kinases in T cell-mediated inflammation. A disease. M.C. Carroll. Boston’s Children’s Hosp. T.-H. Tan. Natl. Hlth. Res. Inst., Taiwan. T 9:10 Non-canonical functions of complement in inflammatory diseases. Jorg¨ Kohl.¨ Univ. of Lubeck,¨ Germany. 80. BASIC AUTOIMMUNITY: T CELLS 9:45 Pattern recognition receptor signalling in response to Block Symposium bacterial Infection. C.E. Bryant. Univ. of Cambridge, England. SAT. 8:00 AM—ROOM 32AB 10:20 Regulation of intestinal inflammation by NLRs and the CHAIRS: Y-G. CHEN, A. PERL gut microbiota. G.Y. Chen, Univ. of Michigan. 10:55 The how and why of lncRNA function during 8:00 Biomarker discovery in pre-type 1 diabetes; Th40 cells inflammation. S. Carpenter, Univ. of California, as a predictive risk factor. G. Vaitaitis, D. Waid and Santa Cruz. D.H. Wagner. Univ. of Colorado Anschutz Med. Campus. (115.4) 78. MAJOR SYMPOSIUM D: STRUCTURAL AND 8:15 Rab4A inactivation in T cells blocks mTOR activation, CELLULAR ASPECTS OF INNATE pro-inflammatory lineage development, and disease LYMPHOCYTES pathogenesis in lupus-prone mice. N. Huang, B. Wyman, E. Cravo, T. Winans, G. Choudhary, Major Symposium Z. Oaks, M. Duarte, J. Lewis, Z-W. Lai, K. Banki and A. Perl. State Univ. of New York Upstate Med. SAT. 8:00 AM—BALLROOM 20BC Univ. (115.6) CHAIRS: E.J. ADAMS, J. SUN. 8:30 IL-23 is essential for the switching between Tfh-IFN-g 8:00 Molecular recognition by immune receptors. E.J. Adams. and Tfh-IL-17 in lupus. H. Hong, Q. Wu, P. Yang, Univ.ofChicago. B. Luo, J. Li, H. Li, D.J. Cua, H-C. Hsu and 8:42 Epigenetic and transcriptional control of innate J.D. Mountz. Univ. of Alabama, Birmingham, St. ’ lymphocytes. J. Sun. Mem. Sloan Kettering Cancer John s Episcopal Hosp., Harvard Med. Sch. and Ctr. Merck Res. Lab. (115.1) fi 9:24 Structural anatomy of the T cell receptor complex: 8:45 One size does not t all: SLAM-associated protein is towards understanding of function. L. Teyton. dispensable for type 1 diabetes but required for Scripps Res. Inst. autoantibody-mediated arthritis. R. Bonami, 10:06 Tuning the natural killer response. C. Blish. Stanford L. Nyhoff, C. Hulbert, J. Felton, P.L. Kendall and Univ. J.W. Thomas. Vanderbilt Univ. Med. Ctr. (115.14) 10:48 Innate lymphocyte responses to viral infection. 9:00 Pathogenic follicular CD8 T cells acquire diverse M.A. Delgi-Esposti. Univ. of Western Australia, function during autoimmune disease. Australia. K.M. Valentine, G.N. Mullins, T.J. Lawrence and K.K. Hoyer. Univ. of California, Merced and Oak Ridge Natl. Lab. (115.22) 79. CHINESE SOCIETY OF IMMUNOLOGY, TAIWAN 9:15 CNS-specific autoregulatory CD8 T cells rely on IFNg (CSIT) SYMPOSIUM: HOST DEFENSE AGAINST signaling for optimal suppression of pathogenic CD4 MICROBIAL INFECTION T cell responses during inhibition of demyelinating Guest Society Symposium disease. A. Boyden, A.A. Brate, L.G. Laageide and N.J. Karandikar. Univ. of Iowa Hlth. Care. (115.9) — SAT. 8:00 AM ROOM 26AB 9:30 NKG2D signaling within the pancreas decreases NOD CHAIRS: J. TING, S.-L. HSIEH diabetes by enhancing CD8+ central memory T cell formation. M.A. Markiewicz, A.P. Trembath, 8:00 Targeting siglec for immunotherapy against HBV N. Sharma and C.E. Mathews. Univ. of Kansas infection. S.-L. Hsieh. Academia Sinica, Taiwan. Med. Ctr. and Univ. of Florida. (115.16)

43 SATURDAY—AM

9:45 Single-cell transcriptome analysis reveals diverse islet- 82. CELLULAR MECHANISMS OF INNATE infiltrating T cell subsets and a role for BATF in IMMUNITY II promoting the diabetogenic activity of CD8 T cells. A.E. Ciecko, D.M. Schauder, B.M. Foda, C-W. Lin, Block Symposium W. Cui and Y-G. Chen. Med. Col. of Wisconsin and SAT. 8:00 AM—ROOM 31ABC Blood Res. Inst. (115.20) CHAIRS: C. SOKOL, R. SINGH 81. MOLECULAR MECHANISMS OF HELPER 8:00 Epithelial versus myeloid-derived IL-33 controls T CELL DIFFERENTIATION different aspects of pathogen-specific immunity. D.R. Herbert, K. Herbine, L-Y. Hung, C. Pastore, Block Symposium B. Singh, Y. Tanaka, P.J. Bryce and SAT. 8:00 AM—ROOM 30CDE T. Kambayashi. Univ. of Pennsylvania, Univ. of Pennsylvania Sch. of Vet. Med. and Feinberg Sch. CHAIRS: M. KAPLAN, H. ZENG of Med., Northwestern Univ. (126.1) 8:00 Reciprocal regulation of Th2 and Th17 cells by PAD2- 8:15 Basophil-derived tumor necrosis factor can enhance mediated citrullination. B. Sun, H-H. Chang, immune responses in a sepsis model in mice. A. Salinger, B. Tomita, M. Bawadekar, A.M. Piliponsky, AJ. Shubin, A. Lahiri, M.A. Shelef, E. Weerapana, P.T. Thompson and P. Truong, M. Clauson, K. Niino, A. Tsuha, I-C. Ho. Brigham and Women’s Hosp., Univ. of SA. Nedospasov, H. Karasuyama, L. Reber, Massachusetts Med. Sch., Univ. of Wisconsin, MM. Tsai, K. Mukai and S.J. Galli. Seattle Madison and Boston Col. (124.2) Children’s Res. Inst., Russian Acad. of Sci., Tokyo 8:15 Transcriptional regulation of IL-10 in T helper cells. Med. and Dent. Univ., Japan and Stanford Univ. Sch. H. Zhang, A. Madi, N. Yosef, N. Chihara, of Med. (126.2) A. Awasthi, C. Pot, L. Apetoh, A. Srivastava, 8:30 Maternal EGF limits bacterial translocation in the C. Wang, A. Regev and V. Kuchroo. Brigham and offspring: a model of enterally acquired late onset Women’s Hosp., Harvard Med. Sch. and MIT and sepsis. K.A. Knoop, P. Coughlin, A. Floyd, C. Hall- Harvard. (124.14) Moore, M. Ndao, B. Warner, P. Tarr and 8:30 Tbet provides survival advantage to Tregs during type 1 R. Newberry. Washington Univ. Sch. of Med. (126.3) inflammation. B. Akkaya, M. Akkaya, J.A. Al Souz, 8:45 Unique innate functions of fetal macrophage A.H. Holstein, M. Maz, J. Kabat, O. Kamenyeva populations. L.S. Prince, O. Lakhdari and and E.M. Shevach. NIAID, NIH. (124.8) K. Anderson. Univ. of California, San Diego, and 8:45 Helios predisposes human fetal CD4+ naive T cells Rady Children’s Hosp., San Diego. (126.4) toward regulatory T cell differentiation. M. Ng, 9:00 Microglial antigen presentation is required for antigen- T. Roth, V. Mendoza, A. Marson and T. Burt. specific CD8 T cell infiltration to the brain parenchyma Univ. of California, San Francisco. (124.9) following CNS viral challenge. E. Goddery, C. Malo, 9:00 Batf promotes and stabilizes Th17 cell development by F. Jin, M. Hansen, J. Fryer, K. Pavelko and antagonizing the actions of STAT5. D. Pham, A. Johnson. Mayo Clin. Grad. Sch. of Biomed. D.J. Silberger, R.D. Hatton and C.T. Weaver. Sci., NIAID, NIH, Mayo Clin., Rochester and Mayo Univ. of Alabama at Birmingham. (124.10) Clin., Jacksonville. (126.5) 9:15 Regulation of Tfh cell development through STAT1 9:15 Analysis of mGBPs in host defense against the obligate signaling. L. Qin, A. Sahoo, Y. Zhao, A. Alekseev parasite Toxoplasma gondii. N. Steffens, and R.I. Nurieva. Univ. of Texas MD Anderson L. Legewie, C. Beuter-Gunia, P. Hanisch, Cancer Ctr. (124.12) S. Weidtkamp-Peters, S. Hansch,¨ D. Degrandi 9:30 T-bet expression is fine-tuned for balancing IFN- and K. Pfeffer. Heinrich-Heine University, g-producing Th1 and Tfh cell differentiation and Duesseldorf, Germany and Heinrich-Heine Univ., IgG2a(c) production. D. Fang, M. Zheng, K. Mao, Duesseldorf, Germany. (126.6) S.L. Reiner, A. Sher and J. Zhu. NIAID, NIH and 9:30 Repeated malaria exposures associate with skewing of Columbia Univ. Med. Ctr. (124.13) monocytes/macrophages toward a regulatory phenotype. R. Guha, G. Arora, S. Li, D. Doumtabe, O.k Doumbo, S. Doumbo, REMINDER K. Kayentao, A. Ongoiba, B. Traore and P.D. Crompton. NIAID, NIH, LIG, NIAID, NIH and Univ. of Sci., Techniques and Technologies of Bamako, Mali. (126.7) 9:45 Differential effects of glycerophospholipids versus glycosphingolipids on dendritic cell subsets. R.R.aj Singh and R. Halder. David Geffen Sch. of Med., Univ. of California, Los Angeles. (126.8)

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83. IMMUNE DEVELOPMENT AT MUCOSAL SITES 8:15 A robust human immunophenotyping workflow using CyTOF technology coupled with Maxpar Pathsetter, Block Symposium an automated data analysis software. S.K.H. Li, SAT. 8:00 AM—ROOM 33ABC D. Majonis, C.B. Bagwell, B.C. Hunsberger, V. Baranov and O. Ornatsky. Fluidigm, Canada CHAIRS: R. O’CONNELL, K. MICHELSEN and Verity Software House. (131.2) 8:00 Absence of conventional dendritic cells type 1 impairs 8:30 Integration of multi-omics data from re-wilded laboratory intestinal homeostasis and permeability and leads to mice to identify key parameters that determine the development of obesity. H. Hamade, immune heterogeneity and activation. J-D. Lin, J.T. Stamps, L.S. Thomas, D. Stamps, F. Yeung, C. Devlin, Y-H. Chen, C. Mccauley, Y. Shimodaira and K.S. Michelsen. Cedars-Sinai A. Cronkite, J.M. Leung, A.L. Graham, Med. Ctr., Los Angeles. (129.6) K.H. Cadwell and P. Loke. NYU Med. Ctr., Univ. 8:15 Tissue driven influences on human NK cell of Central Florida Col. of Med. and Princeton Univ. development, function and residence. P. Dogra, (131.3) C. Rancan, W. Ma, M. Toth, T. Senda, 8:45 Scalable and comprehensive characterization of D.J. Carpenter, P. Thapa, P.A. Szabo, Y. Shen, antigen-specific CD8 T cells using multi-omics L. Fong, L.L. Lanier and D.L. Farber. Columbia single cell analysis. S.C. Boutet, D. Walter, M.J. S Univ. Med. Ctr., Univ. of California, San Francisco T. Stubbington, K.A. Pfeiffer, J.Y. Lee, S.E. A and Univ. of Debrecen, Hungary. (129.8) B. Taylor, L. Montesclaros, J.K. Lau, + T 8:30 Indiscriminate nature of lung resident CD8 TRM cells D.P. Riordan, A.M. Barrio, L. Brix, K. Jacobsen, reactivation and their varied reactivation profiles. B. Yeung, X. Zhao and T.S. Mikkelsen. 10x J.S. Low, C. Amezcua, E. Sefik, C.C.D. Harman, Genomics, Immudex, Denmark and BioLegend, R. Jackson, X. Jiang, J.B. Kelly, L.S. Cauley, Inc. (131.4) R.A. Flavell and S. Kaech. Yale Univ. Sch. of 9:00 Immunophenotyping extracellular vesicles using the Med., Stony Brook Univ., Univ. of Connecticut and CellStream flow cytometer. H.R. Pugsley, The Salk Inst. (129.9) B.R. Davidson and P. Morrissey. Luminex Corp. 8:45 Memory B cell recruitment to the vaginal mucosa is (131.5) required for luminal antibody secretion. J.E. Oh, 9:15 A novel method for high throughput TCR single cell N. Iijima and A. Iwasaki. Yale Univ. Sch. of Med. VDJ-pairing with phenotypic analysis. M. Byrne- (129.16) Steele, W. Pan, B.E. Brown, X. Hou, M. Depinet, 9:00 Intestinal goblet cells and goblet cell-associated antigen M. Eisenhower, D. Weber and J. Han. iRepertoire. passages regulate the balance between Tregs and (131.6) Th17. D.H. Kulkarni, J. Gustafsson, J. Davis, 9:30 Development of high-throughput methods used to K. McDonald, C. Hsieh and R.D. Newberry. identify and characterize novel interactions within Washington Univ., St. Louis. (129.17) the human secretome with focus on the Ig and 9:15 The skin: a site of extralymphoid IgM production. TNF receptor superfamilies. S.C. Garrett-Thomson S.E. McGettigan, R.P. Wilson, V.D. Dang, and S. Almo. Albert Einstein Col. of Med. (131.8) A. Kumar, N. Nikbakht, W. Stohl and 9:45 Developing a novel multiplexed high throughput flow G.F. Debes. Thomas Jefferson Univ., Univ. of cytometry based immune assay to screen kinase Pennsylvania and Univ. of Southern California. modulators of primary T cell activation. (129.5) J. O`Rourke, A. Gomez-Donart, C. Weldon and 9:30 Adventitial stromal cells define group 2 innate lymphoid Z. Liu. Essen Biosciences. (131.7) cell tissue niches. A.B. Molofsky, M.W. Dahlgren, S.W. Jones, A. Dubinin, S. Farhat, J.F. Ortiz- 85. NEW TREATMENTS FOR AUTOIMMUNE Carpena, K.S. Yu, K. Lee, C. Wang, A.V. ARTHRITIS AND SKIN DISEASE R. Molofsky, A.D. Tward, M.F. Krummel and T. Peng. Univ. of California, San Francisco. (129.1) Block Symposium fi 9:45 Dissecting the tissue-speci c mechanisms that support SAT. 8:00 AM—ROOM 29ABCD the maintenance of intestinal regulatory T cells. E. Cruz Morales, A.P. Hart and T.M. Laufer. CHAIRS: S.G. ZHENG, G. RANDOLPH Univ. of Pennsylvania. (129.4) 8:00 Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39- 84. TECHNOLOGICAL INNOVATIONS II adnosine signal pathway in autoimmune arthritis. S.G. Zheng, Y. Luo and J. Wang. Penn State Col. Block Symposium of Med. (133.1) SAT. 8:00 AM—ROOM 30AB 8:15 Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid CHAIRS: L. STERN, N.G. SGOURAKIS arthritis. C. Raffin, Y. Muller, J. Barragan, 8:00 Buoyant microbubbles as alternatives or adjuncts to Y. Zhou, L. Piccoli, A. Lanzavecchia, magnetic bead methods for high-purity cell S.U. Tareen, J.D. Fontenot and J.A. Bluestone. isolation. J.G. Younger, J. Roussey, J. Bao, Univ. of California, San Francisco, IRB Barcelona, N. Petlakh Co, T. Jones and L. Ostruszka. Spain, Inst. for Res. in Biomed., Switzerland and Juno Akadeum Life Sci. (131.1) Therapeutics. (133.2)

45 SATURDAY—AM

8:30 Identification of potent RORc inhibitors for the treatment 8:30 Herpesvirus entry mediator promotes Th1 responses in of IL-17-mediated inflammatory diseases: is it worth the cornea during ocular HSV-1 infection. S.J. Park, the risk? C. Everett, J. Zbieg, O. Rene, S. Rutz, R. Riccio, S. Kopp and R. Longnecker. Feinberg W. Lee, S. Laing, J. Zhang, A. Johnson, Sch. of Med., Northwestern Univ. (140.3) N. Ghilardi, J. Crawford and C. Eidenschenk. 8:45 Cytotoxic CD4 T cells control host immunity during viral Genentech, Inc. and Novartis Institutes of Biomed. persistence. N. Thiault, M. Husain, A. Chen, Res. (133.3) G. Verstichel, A. Larange, V. Shivagouda Patil, 8:45 Therapeutic vaccination by two DerG LEAPS P. Vijayanand, M. Kronenberg and H. Cheroutre. conjugates incorporating different PG (aggrecan) La Jolla Inst. for Immunology. (140.4) epitopes protect by different immune mechanisms 9:00 Monocytes and macrophages limit systemic infection in the PG G1 domain induced mouse model of and modulate the CD4 T cell response during Zika rheumatoid arthritis. D.H. Zimmerman, K. Mikecz, virus infection in mice. Y-T. Wang, S. Hattakam, K.S. Rosenthal, A. Markovics, R. Carambula, M.P. Young, J.A. Regla-Nava and S. Shresta.La J. Ciemielewski and T. Glant. CEL-SCI Jolla Inst. for Immunology. (140.5) Corporation, Rush Univ. Med. Ctr. and Roseman 9:15 PSGL-1 is a negative regulator of effector and memory Univ. of Hlth. Sci. (133.4) T cells. R. Tinoco and L.M. Bradley. Univ. of 9:00 N-acetylcysteine reduces reactive oxygen species and California, Irvine and Sanford Burnham Prebys pro-inflammatory cytokine production in HLA-B27- Med. Discovery Inst. (140.6) positive macrophages and shapes them towards a 9:30 The role of mTOR, TRAF1, and local antigen in 4-1BB- quiescent metabolic state. F. Navid, B. Nguyen, dependent establishment of Trm in the lung. A. Cougnoux, P-C. Violet, M. Levine and N.V. Batista, A.C. Zhou and T.H. Watts. Univ. of R.A. Colbert. NIAMS, NIH, NICHD, NIH and Toronto, Canada. (140.7) NIDDK, NIH. (133.11) 9:45 The pleiotropic effects of PTPN22 and its pro- 9:15 Interleukin-17 drives interstitial entrapment of tissue autoimmune alternative allele on the anti-viral lipoproteins in experimental psoriasis. P. Huang, immune response and T cell exhaustion. B. Zinselmeyer, B.T. Saunders, M.A. Swartz, R.C. Orozco, K. Marquardt, K.A. Mowen, B.S. Kim and G.J. Randolph. Washington Univ. I. Pratumchai, J.R. Teijaro and L.A. Sherman. Sch. of Med. and Univ. of Chicago. (133.5) Scripps Res. Inst. (140.8) 9:30 Targeting chemokine receptors CCR6 and CXCR2 in a murine model of IL-36a-induced pustular psoriasis. 87. NIH GRANT REVIEW AND FUNDING J.J. Campbell, K. Ebsworth, L. Ertl, J.P. McMahon, INFORMATION ROOM Y. Wang, S. Yau, V.R. Mali, V. Chhina, A. Kumamoto, S. Liu, T. Dang, D. Newland, Career Development Session I.F. Charo, P. Zhang, T.J. Schall and R. Singh. SAT. 9:30 AM (ALL DAY)—ROOM 21 ChemoCentryx, Inc. (133.7) 9:45 Restraining neuroinflammation during antigen delivery NIH program and review staff will be available for individual as an immunosuppressive approach to prevent and conversations and consultations. Staff members will answer fi treat contact dermatitis. M. Bandyopadhyay, questions about the scienti c review process, grant/fellowship fi A.E. Morelli, G. Erdos, T.L. Sumpter, opportunities, and NIH Institute speci c interests. Consultations O.A. Tkacheva, W.J. Shufesky, L.D. Falo and will be available on a drop-in basis. No appointments are A.T. Larregina. Univ. of Pittsburgh Sch. of Med. necessary. (133.6)

86. VIRUSES AND THE T CELL RESPONSE Block Symposium

SAT. 8:00 AM—ROOM 25ABC

CHAIRS: A. AUGUST, T. WATTS 8:00 ITK regulates antigen-specific CD8+ T cell-derived IL-10 production and modulates influenza-induced pulmonary immunopathology. W. Huang, S. Solouki and A. August. Sch. of Vet. Med., Louisiana State Univ. and Col. of Vet. Med., Cornell Univ. (140.1) 8:15 Single-cell transcriptomics identifies TOX as a key transcriptional regulator of stem-like CD8 T cells in chronic infection. T. Wu, C. Yao, H. Sun, N. Lacey, L. Gattinoni, D.B. McGavern, J.J. O’Shea and P.L. Schwartzberg. NIAID, NIH, NIAMS, NIH, NCI, NIH and NINDS, NIH. (140.2)

46 SATURDAY—AM

88. FOSTERING DIVERSITY AND PREVENTING 90. NATIONAL INSTITUTE OF ENVIRONMENTAL HARASSMENT IN THE BIOMEDICAL HEALTH SCIENCES (NIEHS) SYMPOSIUM: THE RESEARCH WORKFORCE MISSING LINK: OUR ENVIRONMENT AND Committee-Sponsored Session IMMUNE MEDIATED DISEASES Sponsored by the AAI Committee on Public Affairs, the NIH-Sponsored Session AAI Minority Affairs Committee, and the AAI Committee on SAT. 10:15 AM—ROOM 25ABC the Status of Women CHAIRS: M.C. HUMBLE, C. BEAMER SAT. 10:15 AM—ROOM 33ABC 10:15 Involvement of ahR in thymic ILC function and CHAIRS: D.D. CHAPLIN, R.J. BINDER, L.A. SOLT regulation. C. Beamer. Univ. of Montana. AAI believes that science thrives when all scientists thrive. 10:45 Regulation of cellular energetics by the aryl And while the current biomedical research workforce is more hydrocarbon receptor during hematopoiesis. M. diverse and welcoming than ever before, it is insufficiently Laiosa. Univ. of Wisconsin, Milwaukee. 11:15 Aryl hydrocarbon receptor on CD4+ T cell differentiation diverse—and all too often unwelcoming—to female and and autoimmune disease. S. McKarns. Univ. of underrepresented minority scientists. Both the federal S government through its Government Accountability Office Missouri, Columbia. (GAO), and the National Academies of Sciences, Engineering, 11:45 The AHR as a driver of cancer and immunosuppression. A and Medicine (NASEM), have recently spoken out on these D. Sheer. Boston Univ. T concerns. An August 2018 GAO report examines progress that the NIH has made in increasing the diversity of the 91. KOREAN ASSOCIATION OF IMMUNOLOGISTS biomedical research workforce and challenges NIH to do (KAI) AND ASSOCIATION OF KOREAN more. And a June 2018 NASEM report, entitled “Sexual IMMUNOLOGISTS IN AMERICA (AKIA) Harassment of Women, Climate, Culture, and Consequences SYMPOSIUM: HOST AND MICROBIAL in Academic Sciences, Engineering, and Medicine,” describes FACTORS SHAPING ADAPTIVE IMMUNITY continuing “biases and barriers,” including sexual harassment, that are faced by women scientists, and recommends ways to Guest Society Symposium combat the problem. SAT. 10:15 AM—ROOM 26AB This session will explore NIH actions to strengthen the HAIRS A. YI, E.-C. SHIN diversity of the biomedical research workforce and address C : recommendations highlighted by the GAO report. It will also 10:15 Characteristics and regulation of human liver resident T focus on the NASEM report, and delve into a key finding: cells. E.-C. Shin. Korea Adv. Inst. of Sci. and “Diverse, inclusive, and respectful academic environments are Technol., Korea. environments where careers flourish, but sexual harassment 10:45 The role of cytokine receptors in defining human T cell does not.” subsets. I. Kang. Yale Univ. 10:15 Introduction, D.D. Chaplin, Univ. of Alabama at 11:15 Regulation of T cell metabolism by promyelocytic fi Birmingham leukemic zinc nger (PLZF). C.-H. Chang. Univ. of Michigan, Ann Arbor. SPEAKERS: 11:45 Proinsulin shares a motif with IL-1a and induces fl • Sexual harassment in academia: the NASEM report in ammatory cytokine via IL-1R1. S. Kim. Konkuk and recommendations. E.L. Hillman, Mills Col. Univ., Korea. • NIH’s scientific approach to inclusive excellence. H.A. Valantine. NIH. • What can academic institutions do to address diversity and inclusion? A. August. Cornell Univ.

89. INTERVIEWING FOR A JOB Career Development Session

SAT. 10:15 AM—ROOM 32AB

CHAIR: M.T. LITZINGER This session will be focused on tips and techniques to help you successfully navigate the interview process. Emphasis will be on how you can present yourself in the best possible light. You will also learn how to respond to unexpected questions. This session is open to anyone but is especially intended for student and postdoctoral attendees. 10:15 Introduction. M.T. Litzinger. AAI. 10:20 Interviewing for a Job. D. Haseltine. Baylor Col. of Med.

47 SATURDAY—AM

92. I’M ON FIRE: LOCAL CONTROL OF TISSUE 93. EPIGENETIC AND METABOLIC REGULATION INFLAMMATION OF IMMUNITY Block Symposium Block Symposium

SAT. 10:15 AM—ROOM 30AB SAT. 10:15 AM—ROOM 31ABC

CHAIRS: S.C. MORLEY, J. NOLZ CHAIRS: P. KING, W.K.E. IP 10:15 Neuroinflammation functionally regulates CNS 10:15 Choline uptake and metabolism modulate macrophage lymphatic vasculature and drainage. M. Hsu, immunity. E. Sanchez-Lopez, Z. Zhong, A. Rayasam, J.A. Kijak, Y.H. Choi, J.S. Harding, A. Stubelius, S.R. Sweeney, L. Booshehri, S.A. Marcus, W.J. Karpus, M. Sandor and Z. Fabry. L. Antonucci, R. Liu-Bryan, A. Lodi, Univ. of Wisconsin, Madison, Univ. of California, San R. Terkeltaub, J.C. Lacal, A.N. Murphy, Francisco and Mount Sinai Hosp., Toronto, Canada. H.M. Hoffman, S. Tiziani, M. Guma and M. Karin. (117.13) Univ. of California, San Diego Sch. of Med., Univ. of 10:30 Peripherally induced tissue resident memory CD8 Texas Southwestern Med. Ctr., Univ. of Texas, Austin T cells in the brain mediate protection against CNS and Hosp. Univ. Fuenlabrada, Spain. (125.1) infections. S.L. Urban, I.J. Jensen, L.L. Pewe, 10:30 Chromatin interaction maps of active cis-regulatory V.P. Badovinac and J.T. Harty. Univ. of Iowa elements in primary human immune cells reveal Carver Col. of Med. (117.4) extensive overlap with disease-associated genetic 10:45 Targeted expansion of tissue-resident CD8+ T cells to variants. V. Chandra, S. Bhattacharyya, boost cellular immunity in the skin. S.J. Hobbs and B.J. Schmiedel, A. Madrigal, F. Ay and J.C. Nolz. Oregon Hlth. and Sci. Univ. (117.16) P. Vijayanand. La Jolla Inst. for Immunology. (125.4) 11:00 Type 1 alveolar epithelial cell-derived chemokine 10:45 CTCF is necessary for CD8+ effector T cell CCL19 promotes airway inflammation. H. Nakano, differentiation. S.J. Quon, B. Yu, Z. He, B. Russ, M. Lyons-Cohen, K. Nakano, T. Karcz, S.J. Turner, C. Murre and A.W. Goldrath. Univ. of S.Y. Thomas, G. Whitehead and D.N. Cook. California, San Diego and Univ. of Melbourne, NIEHS, NIH. (117.1) Australia. (125.6) 11:15 Inflammasome activation in macrophages is regulated 11:00 Regulation of T cell activation and pathogenicity by by actin-bundling protein L-plastin. H. Joshi, dimeric pyruvate kinase M2. S. Angiari, C. Sutton, B.E. Todd, T. Szasz, E. Anaya and S.C. Morley. M.C. Runtsch, E.M. Palsson-McDermott, K.H. Washington Univ. Sch. of Med. (117.14) G. Mills and L.A.J. O’Neill. Trinity Col. Dublin, 11:30 EGF-like repeats and discoidin I-like domain 3 Ireland. (125.11) deficiency improves post-myocardial infarction 11:15 IL-33 induces a metabolic programming supporting healing via neutrophil extracellular traps mediated dendritic cells tolerogenicity. M. Velayutham, pro-inflammatory macrophage polarization. X. Wei, A.S. Roessing, S. Shiva and H.R. Turnquist. C. Zhang, Z. Xie, X. Teng, Z. Wang, H. Zheng, Univ. of Pittsburgh Sch. of Med. (125.12) S. Zou, N. Huang, K. Cui and J. Li. West China 11:30 Macropinocytosis of amino acids regulates T cell growth Hosp., Sichuan Univ., China and Univ. of Michigan, by promoting the sustained activation of mTORC1. Ann Arbor. (117.9) J. Charpentier, P.E. Lapinski, J. Turner, 11:45 The impact of the TRPM2 ion channel on inflammation I. Grigorova, J.A. Swanson and P.D. King. Univ. and macrophage metabolism in gastrointestinal of Michigan Med. Sch. (125.14) models. H.M.S. Algood, B.R.E.A. Dixon, 11:45 A “sweet spot” for complement receptor CD46 activity D. Olivares-Villagomez, C.H. Serezani, via direct regulation of glycolytic vs. moonlighting M.K. Washington, J.C. Rathmell and functions of GAPDH. N. Kunz, G. Le Friec, L.A. Coburn. Vanderbilt Univ. Med. Ctr. (117.20) P. Singh, P. Lavender, M. Kazemian, C. Hess 12:00 Choline acetyltransferase-expressing T cells are and C. Kemper. NHLBI, NIH, Sch. of Immunology required to control chronic viral infection. M.A. Cox and Microbial Sci., King’s Col. London, United and T. Mak. Princess Margaret Cancer Ctr. (117.17) Kingdom, Purdue Univ. and Univ. of Basel, Switzerland. (125.15) 12:00 Co-stimulation–induced AP-1 activity is required for chromatin opening during T cell activation. A. Barski, M. Yukawa, S. Jagannathan, A.V. Kartashov, X. Chen and M.T. Weirauch. Cincinnati Children’s Hosp. Med. Ctr. (125.13)

48 SATURDAY—AM

94. INNATE AND ADAPTIVE CONTROL OF 95. MACROPHAGES AND MYELOID AND ALLOGRAFT REJECTION DENDRITIC CELLS IN TUMOR IMMUNITY AND Block Symposium IMMUNOTHERAPY Block Symposium SAT. 10:15 AM—ROOM 30CDE SAT. 10:15 AM—ROOM 29ABCD CHAIRS: A. WELLS, X. LUO HAIRS S. CASCIO, R. YOUNIS 10:15 Inducible nitric oxide synthase-mediated inhibition of C : T cell receptor signaling is a mechanism for 10:15 Paradoxical pro-tumor functions of dendritic cells on eosinophil dependent amelioration of alloimmunity colorectal cancer. H-I. Huang and G. Hammer. in lung grafts. O.O. Onyema, Y. Guo, Duke Univ. (135.1) B. Mahgoub, A. Manafi, S. Criswell, J. Lannigan, 10:30 The role of neutrophil extracellular traps in nonalcoholic E.A. Jacobsen, A.E. Gelman, D. Kreisel and steatohepatitis-associated hepatocellular carcinoma. A.S. Krupnick. Univ. of Virginia, Mayo Clin. and H. Zhang, D.J. van der Windt, J. Ren, A. Tsung and Washington Univ., St. Louis. (69.9) H. Huang. Ohio State Univ., Wexner Med. Ctr. and 10:30 Type-1 interferons impair the immunoregulatory activity Univ. of Pittsburgh Med. Ctr. (135.2) of IL-10: understanding novel mechanisms of 10:45 Non-small cell lung cancer tumor microenvironment S abrogation of transplant tolerance. M. Iglesias induces arginase1 in neutrophils via the toll-like A Lozano, D. Bibicheff, M. Chicco, G. Brandacher receptor 2 signaling pathway. H. Zhang, J. Kargl, T and G. Raimondi. Johns Hopkins Univ. Sch. of Med. X. Zhu, X. Wang, J. Cao and A.M. Houghton. Fred (69.33) Hutchinson Cancer Res. Ctr. and Med. Univ. of Graz, 10:45 IL-1b and IL-6 facilitate T cell reconstitution in heart Austria. (135.3) allograft recipients treated with anti-thymocyte 11:00 Single cell RNA sequencing reveals distinct gene globulin. S. Hasgur, R. Fan, D. Zwick and expression signatures of myeloid-derived A. Valujskikh. Cleveland Clin. (69.29) suppressor cells in breast cancer. H. Alshetaiwi, 11:00 Alloreactive B cells acquire suppressive function in N. Pervolarakis, L.L. McIntyre, D. Ma, recipients tolerant to allografts. S. Khiew, D. Yin, Q. Nguyen, K. Nee, J. Rath, K. Evans, D. Jain, Q. Wang, M-L. Alegre and A.S.F. Chong. L. Torosian, A. Silva, C. Walsh and Univ. of Chicago. (69.12) K. Kessenbrock. Univ. of California, Irvine, Sch. of 11:15 Kidney allograft recipient absence of myeloperoxidase Med., Univ. of California, Irvine, Sch. of Bio. and Univ. decreases donor-specific antibody titers and of California, Irvine, Sch. of Hlth. and Pharmaceutical attenuates antibody-mediated allograft rejection. Sci. (135.4) R.L. Fairchild, S. Miyairi, N. Dvorina, 11:15 The cross-talk between infiltrating macrophages and A. Valujskikh and W.M. Baldwin. Cleveland Clin. inflamed or malignant colonic epithelium promotes (69.14) overexpression of ST6GALNAC1 and epithelial 11:30 Foxp3 cooperates with Ikaros to control the suppressive MUC1 tumor form MUC1-sTn. S. Cascio, function of regulatory T cells. R.M. Thomas, M. Kvorjak, Y. Ahmed, M. Miller, J. Al Hashash, L. Wang, C. Chen, W.W. Hancock and D. Hartman, N. Miskov-Zivanov, C. Telmer and A.D. Wells. Children’s Hosp. of Philadelphia. (69.23) O.J. Finn. Univ. of Pittsburgh Sch. of Med. and 11:45 Inhibition of the Cullin RING E3 ubiquitin ligase by Carnegie Mellon Univ. (135.5) MLN4924 targets DEPTOR degradation in Tregs to 11:30 The fate of leukemia-specific CD8+ T cell clones is enhance their stability and functional activity. dictated by antigen specificity and the mechanism J. Wedel, K. Liu and D.M. Briscoe. Boston of cognate antigen presentation. X. Chen, B. Flood, Children’s Hosp. (69.13) B. MacNabb, B.R. Blazar and J. Kline. Univ. of 12:00 Bcl-2 inhibition with venetoclax promotes induction of Chicago and Univ. of Minnesota. (135.6) mixed chimerism and renal allograft tolerance without 11:45 Tumor-derived retinoic acid promotes immune severe myelosuppression in non-human primates. suppression in sarcoma. S. Devalaraja, T. To, T. Kawai, H. Sasaki, D. Ma, A. Dehnadi, I. Folkert, M. Li, Y. Tada and M. Haldar. A.B. Cosimi, P. Cippa and T. Fehr. Perelman Sch. of Med., Univ. of Pennsylvania. Massachusetts Gen. Hosp. and Univ. of Zurich, (135.7) Switzerland. (69.8) 12:00 ST8Sia6 overexpression accelerates tumor growth, alters macrophage polarization and the immune response. D.J. Friedman, M. Shapiro, M. Rajcula, S. McCue and V. Smith Shapiro. Mayo Clin. Grad. Sch. of Biomed. Sci. (135.8)

49 SATURDAY—PM SATURDAY AFTERNOON

MAY 11

96. AAI-BIOLEGEND HERZENBERG AWARD ○ Tips for Balancing Teaching and Research PRESENTATION AND LECTURE • Negotiating an Academic Position • Mentoring Effectively The AAI-BioLegend Herzenberg Award recognizes • How to Build a Network for Postdocs fi outstanding research contributions to the eld of immunology • Networking Skills for PIs in the area of B cell biology. Work / Life Balance Awards Lecture Careers in Veterinary Immunology Careers in Biotech and Industry: moving from academia Generously supported by BioLegend to industry and vice versa SAT. 12:30 PM—ROOM 25ABC Careers at Government Agencies NIH Study Section Insights CHAIR: J.L. FLYNN • Grant Writing for Fellowships/Transition Awards • Grant Writing for PIs ’ Recipient: F.W. Alt. HHMI, Boston Children s Hosp. The Physician Scientist: balancing clinical and research 12:30 Introduction and Award Presentation. J.L. Flynn. Univ. duties of Pittsburgh Sch. of Med., AAI President; and Research from the M.D.-Ph.D. Perspective L. Herzenberg. Stanford Univ. Sch. of Med. Non-Research Careers for Scientists: careers enabling 12:35 The fundamental role of chromatin loop extrusion in scientists to advance the field away from the bench antibody diversification. F.W. Alt. HHMI, Boston • Scientific Publishing Children’s Hosp. • Opportunities for Scientists in Foundations/Non-profits • Careers in Science Policy • 97. CAREERS IN SCIENCE ROUNDTABLE Technology Transfer International Opportunities in Science Career Development Session Sponsored by the AAI Education Committee and the AAI 98. HOW TO GET YOUR SCIENCE PUBLISHED: Committee on the Status of Women TIPS ON NAVIGATING THE PROCESS

SAT. 12:30 PM—BALLROOM 20A Committee-Sponsored Session

CHAIR: L.A. SOLT Sponsored by the AAI Publications Committee

Registration Fee: $30 (includes lunch). At this popular SAT. 12:30 PM—ROOM 33ABC session, attendees will have the opportunity to meet with CHAIRS: B.D. EVAVOLD, E.M. OLTZ experienced scientists to explore specific career issues important to men and women in science today. Gain insights In this session sponsored by the AAI Publications into issues you are confronting in your own career. Topics include Committee, experienced editors and authors will provide international opportunities in science, succeeding in graduate valuable insights to the processes of preparing a manuscript, school, participating in NIH Study Sections, considerations for responding to reviewers’ comments, and how to avoid possible scientists in M.D.-Ph.D. careers, and exciting careers beyond the ethical missteps in scientific publishing. In addition, the Editor-In- bench. New to the 2019 session are topics on balancing teaching Chief of The Journal of Immunology will speak on the career and research and careers in veterinary immunology. There are benefits of publishing in The JI. also table discussions on navigating work-life issues, such as SPEAKERS: balancing careers with family and transitioning from specific career stages, which may be relevant to any work environment (academic 12:30 You’ve done the research, now tell the story: advice on research, biotech industry, governmental agencies, non-profit). writing manuscripts. B.D. Evavold. Univ. of Utah. Don’t miss this great networking opportunity! 1:00 Advancing your career: why you should publish in The JI. E.M. Oltz. The Ohio State Univ. Col. of Med. Discussion Topics: 1:30 Ethics in scientific publication: a few do’s and a lot of Research Careers in Academia don’ts. C.R. Nagler. The Univ. of Chicago. • Succeeding in Graduate School 2:00 Successfully—and diplomatically—responding to • Postdoc to PI reviewers. S. Ostrand-Rosenberg. Univ. of Utah. ○ Government Research Institutions ○ Medical Schools ○ Undergraduate Institutions • New PI ○ Recruiting Students and Postdocs ○ Preparing for Promotion

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100. INTERNATIONAL COMPLEMENT SOCIETY (ICS) 1:00 Induced hyperglycemia promotes sensitization and SYMPOSIUM: NEWLY DEFINED ESSENTIAL exacerbates allergic inflammation in a mouse ROLES OF COMPLEMENT model of asthma. A. Queener, B.M. Jeong, T.C. Doan, S.E. Chiarella, M.T. Walker, Guest Society Symposium M.E. Coden, R. Nagasaka and S. Berdnikovs. SAT. 12:30 PM—ROOM 26AB Northwestern Univ. (119.3) 1:15 The transcriptional repressor Blimp-1 promotes Th2 CHAIRS: R. TAYLOR, S. RAM development and lung inflammatory disease in a 12:30 Complement as an emerging target for cancer house dust mite-induced model of allergic asthma. immunotherapy. M. Markiewski. Texas Tech Univ. A.C. Poholek, A. Hettinga, K. He, S. Kale, Hlth. Sci. Ctr. E. Schmitz, S. Pandya, M.M. Xie, A. Dent, 1:00 Complement and disease: the changing landscape of T.B. Oriss and A. Ray. Univ. of Pittsburgh Sch. of treatment and therapy. C. Harris. Newcastle Univ., Med. and Indiana Univ., Purdue Univ. Indianapolis. United Kingdom. (119.15) 1:30 Regulation of autophagy by complement component 1:30 IL-9-secreting tissue-resident memory CD4+ T cells C3. A. Blom. Lund Univ., Sweden. contribute to allergic airway recall responses. 2:00 Properdin and Factor H: mechanisms of complement B.J. Ulrich, Y. Fu, B. Koh, R. Kharwadkar and S dysregulation in disease. V. Ferreira. Univ. of Toledo M.H. Kaplan. Indiana Univ. Sch. of Med. (119.13) A fl + Col. of Med. 1:45 Glucocorticoids control allergic in ammation via Foxp3 T regulatory T cells. Q.T. Nguyen and B. Min. 101. THE SOCIETY FOR LEUKOCYTE BIOLOGY Cleveland Clin. Fndn. (119.12) high low (SLB) SYMPOSIUM: EARLY CAREER 2:00 IL-9 GATA3 ILC2s are potent inducers of allergic airway inflammation. P. Schmitt, A. Duval, S. Roga, INVESTIGATORS: HOST DEFENSE AT THE M. Camus, O. Burlet-Schiltz, A. Gonzalez-de- MUCOSAL INTERFACE Peredo, C. Cayrol and J-P. Girard. Institut de Guest Society Symposium Pharmacologie et de Biologie Structurale, France. (119.29) SAT. 12:30 PM—ROOM 30AB 2:15 Combined immune and airway epithelial cell profiles CHAIR: I. MESSAOUDI define asthma severity phenotypes. T.B. Oriss, X. Zhou, M. Camiolo, K.L. Scholl, M. Gorry, 12:30 Respiratory syncytial virus infection in early life results in M. Gauthier, P. Ray, S.E. Wenzel, K.C. Nadeau reduced mucosal T cell responses contributing to and A. Ray. Univ. of Pittsburgh Sch. of Med. and poor tissue-resident memory T cell establishment. Stanford Univ. (119.1) A. Malloy. Uniformed Services Univ. of the Hlth. Sci. 1:00 Post-traumatic pulmonary infection: the innate immune response protects the lung at the expense of the healing cutaneous wound. M. Crane. Brown Univ. 1:30 Flow cytometric analysis of oral neutrophils in mouse and human: identification of unique phenotypes associated with health and inflammation. N. Fine. Univ. of Toronto. 2:00 Antibiotic-mediated antiviral immunity. S. Gopinath. Stanford Univ.

102. IMMUNITY OF ASTHMA Block Symposium

SAT. 12:30 PM—ROOM 32AB

CHAIRS: A. SPERLING, N. HELLER 12:30 IRF4 expression by lung dendritic cells drives a Th2 program throughout the effector and memory allergic responses. D.F. Camacho, E. Wang, C.L. Howard, D.C. Decker, K.M. Blaine, E.P. Darnell, P.A. Krishack, C.L. Hrusch, J.J. Moon and A.I. Sperling. Univ. of Chicago and Harvard Med. Sch. (119.25) 12:45 Impaired tumor-necrosis-factor-a-driven dendritic cell activation limits lipopolysaccharide-induced protection from allergic inflammation in infants. K. Kaur, H. Bachus, A.M. Papillion, T.T. Marquez-Lago, Z. Yu, A. Ballesteros-Tato, S. Matalon and B. Leon-Ruiz. Univ. of Alabama, Birmingham. (119.26)

51 SATURDAY—PM

103. INNATE IMMUNITY AND INFECTIOUS DISEASE 12:45 Neutrophil maturation and their response to infectious pathogens are regulated by microbiota. M. Gadjeva, Block Symposium A. Kugadas, A. Petenkova, J. Geddes-McAlister, SAT. 12:30 PM—ROOM 30CDE M.K. Mansour and D. Sykes. Brigham and Women’s Hosp., Harvard Med. Sch., Max Planck Inst. of CHAIRS: A. DI NARDO, S. WAGGONER Biochemistry, Germany and Massachusetts Gen. 12:30 The lysophosphatidylcholine transporter, MFSD2A, is Hosp. (127.22) essential for CD8+ memory T cell maintenance and 1:00 The host E3-ubiquitin ligase TRIM6 plays an important secondary response to infection. L.M. D’Cruz, role in balancing protective innate antiviral immunity A. Piccirillo, E. Hyzny, A. Menk, C. Wallace, and damaging inflammation. R. Rajsbaum, W.F. Hawse, H.M. Buechel, B. Wong, J.C. Foo, L. Aguilera-Aguirre and A. Hage. Univ. of Texas A. Cazenave-Gassiot, M. Wenk, G.M. Delgoffe, Med. Br. (127.13) S. Watkins and D. Silver. Univ. of Pittsburgh, 1:15 Rapidly evolving PARP proteins act as both positive and Univ. of Pittsburgh Cancer Inst., National Univ. of negative regulators of the antiviral response. Singapore, Singapore and Univ. of Pittsburgh A. Ryan, J. Schwerk, F. Soveg, R. Savan and Cancer Instit. (122.3) M. Daugherty. Univ. of California, San Diego and 12:45 PGAM1 hypomethylation drives aerobic glycolysis in Univ. of Washington. (127.15) CD4 T cells to facilitate the host defense against 1:30 Innate immune role for the macrophage galactose lectin tuberculosis. X. Chen, J. Zhu, C. Zhu, F. Gao and pathway in pulmonary tuberculosis. K.F. Naqvi, Y. Cai. Shenzhen Univ. Sch. of Med., China, Beijing T.B. Saito, M.B. Huante, B.B. Gelman and Chest Hosp., Capital Med. Univ., China and Chinese J.J. Endsley. Univ. of Texas Med. Br. (127.17) Acad. of Agr. Sci., China. (122.6) 1:45 STAT2 is a determinant of yellow fever virus host 1:00 Infant T cells exhibit increased TCR signaling and tropism. J. Morrison, L. Miorin, M. Laurent-Rolle, proliferation to respiratory infection. P. Thapa, G. Pisanelli, P. Co, R. Albrecht and A. Garc´ıa- R.S. Guyer and D.L. Farber. Columbia Univ. Med. Sastre. Univ. of California, Riverside, Icahn Sch. of Ctr. (122.13) Med. at Mount Sinai, Yale Univ. Sch. of Med. and 1:15 Costimulation of type-2 innate lymphoid cells by GITR Queens Col., City Univ. of New York. (127.18) promotes effector function and ameliorates type 2 2:00 Activation of AMPK restricts Zika virus replication in diabetes. L. Galle, I. Sankaranarayanan, endothelial cells by potentiating antiviral response B.P. Hurrell, E. Howard, R. Lo, H. Maazi, and inhibiting viral-induced glycolysis. A. Kumar, G. Lewis, H. Banie, A.L. Epstein, P. Hu, S. Singh, P. Singh and S. Giri. Wayne State Univ. V.K. Rehan, F.D. Gilliland, H. Allayee, Sch. of Med. and Henry Ford Hlth. Sys. (127.19) P. Soroosh, A.H. Sharpe and O. Akbari. Univ. of 2:15 Dual oxidase1 ameliorates survival, viral clearance, and Southern California, Janssen Pharmaceutical Co. of pulmonary pathology during influenza infection. Johnson & Johnson, Harbor-UCLA and Harvard Med. D. Sarr, A. Gingerich, M. Colon, T. Nagy, Sch. (122.10) R.A. Tripp and B. Rada. Univ. of Georgia. (127.21) 1:30 The role of innate immune cells in contact hypersensitivity. K. On, S. Tikoo, R. Jain and 105. IMMUNOMETABOLISM IN TUMOR IMMUNITY W. Weninger. Centenary Inst. of Cancer Med. and AND IMMUNOTHERAPY Cell Biol., Australia. (122.11) 1:45 Dermal fibroblasts control mast cell reactivity to Block Symposium commensal bacteria. Y-L. Chang, K. Sriram, SAT. 12:30 PM—ROOM 29ABCD Z. Wang, S. Igawa, C-C. Wu, P. Insel and A. Di Nardo. Sch. of Med., Univ. of California, San Diego. CHAIRS: E. DAVILA, M. GUBBELS BUPP (122.15) 12:30 Fatty acid depletion is a reversible cause of kynurenine 2:00 Natural killer cell inhibition of HIV vaccine responses. induced T cell apoptosis. U.H. Beier, M.D. Cully, I.E. Gyurova, J.P. McNally, C.E. Rydyznski and P.J. Siska, K. Singer, J. Jiao, T. TeSlaa, S.N. Waggoner. Cincinnati Children’s Hosp. Med. W.J. Quinn, W.W. Hancock, J.A. Baur, Ctr. (122.16) J.D. Rabinowitz and M. Kreutz. Univ. of Pennsylvania, Univ. Hosp. Regensburg, Germany, 104. PATHOGEN CONTROL AND EVASION Children’s Hosp. of Philadelphia and Princeton Univ. (137.1) Block Symposium 12:45 Tumor cell IDO1 increases intratumoral SAT. 12:30 PM—ROOM 31ABC immunosuppressive Tregs independent of enzyme activity. L. Zhai, A. Bell, J. Qian, E. Ladomersky, CHAIRS: M. DAUGHERTY, R. RAJSBAUM K.L. Lauing and D.A. Wainwright. Feinberg Sch. of 12:30 Leishmania major degrades CXCL1 to subvert host Med., Northwestern Univ. (137.2) immune responses. P. Gurung, M. Yorek, B. Poudel and L. Mazgaeen. Univ. of Iowa. (127.3)

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1:00 Blockade of IDO/TDO downstream effectors restricts 4:15 Combination immunotherapy to overcome resistance to cancer immune suppression. L.F. Campesato, CAR T cell therapy. S. Maude. Children’s Hosp. of S. Budhu, J. Tchaicha, A. Jaiswal, M. Gigoux, Philadelphia. S. Pourpe, C. Liu, D. Zamarin, M.G. Manfredi, 4:45 Understanding the CD8+ TILs response to checkpoint K. McGovern, J.D. Wolchok and T. Merghoub. blockade immunotherapy. A. Anderson. Brigham Mem. Sloan Kettering Cancer Ctr. and Kyn and Women’s Hosp. Therapeutics. (137.3) 5:15 CAR T cells for cancer – merging synthetic biology and 1:15 Dynamics of migration patterns of polymorphonuclear immunology. S. Riddell. Fred Hutchinson Cancer myeloid-derived suppressor cells during tumor Res. Ctr. progression. S. Fu, S. Patel, J. Mastio, G.A. Dominguez, K.A. Torres, Y. Nefedova, 108. IMMUNE MECHANISMS OF HUMAN DISEASE J. Zhou and D.I. Gabrilovich. Wistar Inst. and Sun Yat-sen Univ., China. (137.4) Block Symposium 1:30 Suboptimal ER stress-induced autophagy potentiates SAT. 3:45 PM—ROOM 30AB anti-tumor T cell response. P. Chakraborty, S. Chatterjee, D. Tran, S. Nadig, C. Atkinson CHAIRS: N. VAN OERS, K. HASKINS and S. Mehrotra. Med. Univ. of South Carolina. 3:45 Endogenous antisense RNA and dysregulation of CD39 S (137.5) expression in inflammatory bowel disease. A 1:45 Metabolic reprogramming of arginine in tumor stem cells M.S. Longhi, R. Harshe, A. Xie, H. Zhang, T facilitates immune escape. K-H. Chen and R.J. Robles, S. Mukherjee, M. Vuerich, A. Walker. Univ. of California, Riverside. (137.6) A.C. Moss and S.C. Robson. Beth Israel 2:00 Pharmacologic inhibition of liver X receptors enhances Deaconess Med. Ctr. (182.10) T cell anti-tumor function in triple negative breast 4:00 22q11.2 Deletion syndrome (DiGeorge) and mutations cancer. K.J. Carpenter, S. Abuirqeba, S. Majidi, in Forkhead Box N1 (FOXN1) cause a thymic M. Sengupta, A.C. Valfort, A. Chatterjee, hypoplasia through distinct developmental R.J. DiPaolo and C.A. Flaveny. Saint Louis Univ. processes. N.S. van Oers, Q. Du, L. Huynh, (137.7) F. Coskun, I. Dozmorov, P. Raj, S. Khan, C. Wysocki, M.L. Markert and M.T. de la Morena. Univ. of Texas Southwestern Med. Ctr., UT 106. CHINESE SOCIETY FOR IMMUNOLOGY (CSI) Southwestern Med. Ctr., Duke Univ. Med. Ctr. and SYMPOSIUM: INNATE IMMUNITY AND TUMOR Univ. of Washington. (182.32) IMMUNOLOGY 4:15 Age associated insulin resistance is controlled by microbiota through a monocyte-B1a cell pathway. Guest Society Symposium M. Bodogai, J. O’Connell, Y. Kim, J. Egan and

SAT. 3:45 PM—ROOM 26AB A. Biragyn. NIA, NIH. (182.35) 4:30 The impact of IL-27 on human T cells is altered in CHAIRS: B. SUN, R. CASPI multiple sclerosis patients. M-L. Clenet,´ 3:45 ICAM-1 controls development and function of ILC2. C. Laurent, O. Devergne, P. Duquette, A. Prat, J. Zhou. Tianjin Med. Univ., China. C. Larochelle and N. Arbour. Centre de 4:15 Regulatory innate lymphoid cells control innate recherche du CHUM, Canada and INSERM U1151, intestinal inflammation. Z. Fan. Chinese Acad. of France. (182.38) + Sci., China. 4:45 IL-35 regulatory immune cells in diabetic nephropathy. 4:45 Global characterization of T cells in non-small-cell lung K. Singh, Z. Luo, P-O. Carlsson, P. Hansell and cancer by single-cell sequencing. Z. Zhang. Peking S. Sandler. Uppsala Univ. and Uppsala Univ., Univ., China. Sweden. (182.47) 5:15 Tumor-derived exosomes antagonize innate antiviral 5:00 CD4+ T cell antigen discovery in sarcoidosis. immunity. L. Zhang. Zhejiang Univ., China. S.A. Greaves, A. Mitchell, M. Falta, R. Santos, C.A. Pinilla and A.P. Fontenot. Univ. of Colorado 107. SOCIETY FOR IMMUNOTHERAPY OF CANCER Anschutz Med. Campus and Torrey Pines Inst. for Molec. Studies. (182.57) (SITC) SYMPOSIUM: RESISTING FAILURE: 5:15 Long-range cis-regulatory architecture of the human IL2 DISSECTING MECHANISMS OF ACQUIRED gene. P.K. Sharma, R.M. Thomas, M. Johnson and RESISTANCE TO CANCER IMMUNOTHERAPY A. Wells. The Children’s Hosp. of Philadelphia. Guest Society Symposium (182.65) 5:30 Detection and characterization of T cells reactive to — SAT. 3:45 PM ROOM 29ABCD hybrid insulin peptides in patients with type 1 CHAIRS: D. VIGNALI, S. MAUDE diabetes. R.L. Baker, P.A. Gottlieb, T. Delong and K. Haskins. Univ. of Colorado Sch. of Med. fi 3:45 Resistance mechanisms that limit the ef cacy of cancer and Univ. of Colorado, Skaggs Sch. of Pharmacy immunotherapy. D. Vignali. Univ. of Pittsburgh. and Pharmaceutical Sci. (182.72)

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109. B CELLS AND THE CELLS THAT HELP 4:15 Dynamics of antigen re-exposure to CD8+ T cells during Toxoplasma gondii infection. L. Shallberg, Block Symposium A.T. Phan, D.A. Christian and C.A. Hunter. Univ. SAT. 3:45 PM—ROOM 33ABC of Pennsylvania. (190.11) 4:30 Long pentraxin 3 regulates IL-17A mediated immunity to CHAIRS: D. ALLMAN, N. BAUMGARTH primary and secondary Leishmania major infection. 3:45 Protein kinase CK2 drives plasma cell differentiation. G. Gupta, P. Jia, R. Sharma, R. Zayats, L. Shan, H. Wei, W. Yang, Z. Yan, H. Qin and E. Benveniste. Z. Mou, T. Murooka, A. Soussi-Gounni, C.I. de Univ. of Alabama at Birmingham. (188.1) Oliveira and J.E. Uzonna. Univ. of Manitoba, 4:00 IRF4 regulates the proliferative response during B cell Canada and Oswaldo Cruz Fndn., Brazil. (190.21) differentiation in vivo. D. Patterson, C. Scharer, 4:45 Ephrin B receptor tyrosine kinase ligands modulate the T. Mi, S.L. Hicks, Q. Zhang and J.M. Boss. germinal center reaction and control humoral immune Emory Univ. Sch. of Med. and Emory Univ. Sch. of responses to malaria. A.C. Olatunde, P.N. Mimche, Publ. Hlth. (188.2) S.O. Seely, T.P. Stewart and T.J. Lamb. Univ. of 4:15 B cell activation and differentiation employ mTORC1 Utah Sch. of Med. (190.29) rather than Xbp1 to initiate distinct segments of the 5:00 Pathogen evasion of intracellular complement in unfolded protein response prior to antibody secretion. macrophages enables systemic colonization and B.M. Gaudette, D.D. Jones, J.R. Wilmore and bacteremia. M. Valeri, L.A. Knodler, J. Behnsen, D. Allman. Perelman Sch. of Med., Univ. of P. Sharma, L. Chung, J. Cundiff, E. Sanchez- Pennsylvania. (188.3) Lopez, W. Pandori, M. Lodoen, P. Martin, 4:30 E3 ubiquitin ligase Fbw7 regulates B cell survival and R. Edwards, M. Karin, J. Celli, K. Cadwell, T cell-independent responses. P. Ramezani-Rad, S-P. Nuccio and M. Raffatellu. University of C.R. Leung, J.R. Apgar and R.C. Rickert. California, San Diego, Washington State Univ., Sanford Burnham Prebys Med. Discovery Inst. University of California, Irvine, New York Univ. Sch. (188.4) of Med. and Univ. of California, San Diego. (190.6) 4:45 IL-21-dependent Tbet+ B cells require Bcl6 and receive 5:15 Neutrophils transiently harbor Mycobacterium delayed help from non-Tfh T cells. R.C. Levack, tuberculosis and represent a metabolically M. Popescu and G. Winslow. Upstate Med. Univ. permissive niche for bacterial growth. L. Huang (188.5) and D. Russell. Cornell Univ. (190.23) 5:00 Extracellular ST6Gal-1 calibrates B cell IgG production 5:30 Drug treatment of tuberculosis diminishes but does not by cell non-autonomous extrinsic sialylation. abolish the protection against secondary M. E.E. Irons, P.R. Punch and J.T.Y. Lau. Roswell tuberculosis challenge. S.K.C. Ganchua, Park Cancer Inst. (188.6) A.M. Cadena, F.F. Hopkins, S. Fortune and 5:15 IL-12 signaling drives the differentiation and function of J.L. Flynn. Univ. of Pittsburgh Sch. of Med. and aTH1-derived TFH1-like cell population. M.D. Powell, Harvard Sch. of Publ. Hlth. (190.33) K. Read, B. Sreekumar and K.J. Oestreich. Virginia Polytechnic Inst. and State Univ. and Biomed. and 111. GUT MICROBIOTA AFFECT ON HOST Vet. Sci. Grad. Program, Virginia-Maryland Col. of IMMUNITY Vet. Med. (188.7) 5:30 LSD1 epigenetically represses NF-kB target genes to Block Symposium regulate marginal zone B cell development. SAT. 3:45 PM—ROOM 30CDE R.R. Haines, C.D. Scharer and J. Boss. Emory Univ. (188.9) CHAIRS: E. KOLTSOVA, G. CHEN 3:45 The gut microbiome can contribute to colon tumor 110. MICROBIAL, PARASITIC, AND FUNGAL susceptibility via an effect on CD8+ T cell IMMUNOLOGY responses. A.I-W. Yu, S. Ho, J. Chen, C. Koumpouras, L. Zhao, P.D. Schloss, Block Symposium K.A. Eaton and G.Y. Chen. Univ. of Michigan and SAT. 3:45 PM—ROOM 31ABC Univ. of Michigan Med. Sch. (191.1) 4:00 Intestinal IL-17R signaling controls liver inflammation by CHAIRS: M.G. JUARRERO, D.R. HERBERT constraining microbiome-induced TLR9 signaling and 3:45 b-glucan priming enhances neutrophil Fcg receptor- IL-18 production. P. Castillo, P. Kumar, T.W. Hand mediated antifungal activity during oral mucosal and J.K. Kolls. Univ. of Pittsburgh Sch. of Med. and infection. M. Swidergall, N.V. Solis, Z. Wang, Stony Brook Univ. (191.16) Q.T. Phan, M.E. Marshall, M.S. Lionakis, 4:15 Sensing fungal dysbiosis by gut-resident CX3CR1+ E. Pearlman and S.G. Filler. Univ. of California, mononuclear phagocytes aggravates allergic Los Angeles, Univ. of California, Irvine and NIAID, airway disease. X. Li, I. Leonardi, A. Semon, NIH. (190.4) I. Doron, I.H. Gao, G.G. Putzel, Y. Kim, 4:00 Understanding mechanisms of disease tolerance H. Kabata, D. Artis, W.D. Fiers, A.E. Ramer-Tait during intestinal helminth infection. M. Gentile, and I. Iliev. Weill Cornell Med. Col. and Univ. of Y. Li, A. Robertson, G. Fontes, E. Kaufmann, Nebraska, Lincoln. (191.3) N. Khan, H.M. Munter, M. Divangahi and I.L. King. McGill Univ., Canada. (190.27)

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4:30 Cytokine mediated control of microbiota and 5:15 Lung-draining lymph-node-resident memory CD8 inflammation in atherosclerosis. E. Koltsova, T cells mediate local protective immunity. I. Peshkova, A. Dzutsev, T. Aghayaev, S. Hazen, S.M. Anthony, N. Van Braeckel-Budimir, G. Trinchieri and A. Fatkhullina. Fox Chase Cancer S. Moioffer, S.M. Hartwig, S.M. Varga, Ctr., NCI, NIH and Cleveland Clin. (191.12) V.P. Badovinac and J.T. Harty. Carver Col. of 4:45 Microbiota-derived butyrate limits the autoimmune Med., Univ. of Iowa. (198.7) response by promoting follicular regulatory T cells. 5:30 Improved level and longevity of protective immune D. Takahashi, N. Hoshina, J.M. Clarke and responses in measles virus with efficient replication K. Hase. Keio Univ. Fac. of Pharmacy, Japan and in blood and lymphoid tissue. W-H.W. Lin, CSIRO Food and Nutritional Sci., Australia. (191.4) R.J. Adams and D.E. Griffin. Johns Hopkins Univ. 5:00 Metabolic targeting of microbiota-reactive CD4 T Bloomberg Sch. of Publ. Hlth. and Johns Hopkins memory cells as an immunotherapy for Univ. Sch. of Med. (198.8) inflammatory bowel disease. Q. Zhao, L.W. Duck and C.O. Elson. Univ. of Alabama, Birmingham, Sch. 113. AAI-THERMO FISHER MERITORIOUS CAREER of Med. (191.7) AWARD PRESENTATION AND LECTURE 5:15 Zinc supplementation modulates T helper 17 cells via the gut microbiome. S.R. Gordon and S. Vaishnava. The AAI-Thermo Fisher Meritorious Career Award S Brown Univ. (191.13) recognizes a mid-career scientist for outstanding research contributions to the field of immunology. A 5:30 Functional characterization of the enteric animal virome. T S. Dallari, T. Heaney, A. Rosas and K. Cadwell. Awards Lecture New York Univ. Sch. of Med. (191.9) Generously supported by Thermo Fisher Scientific

112. IMMUNE RESPONSE TO RESPIRATORY SAT. 4:30 PM—BALLROOM 20BCD VIRUSES CHAIR: J.L. FLYNN Block Symposium Recipient: K.A. Hogquist. Univ. of Minnesota Ctr. for SAT. 3:45 PM—ROOM 25ABC Immunology CHAIRS: S.M. VARGA, J. WILLIAMS 4:30 Introduction and Award Presentation. J.L. Flynn. Univ. 3:45 A potently neutralizing site III-specific human antibody of Pittsburgh Sch. of Med., AAI President; and prevents human metapneumovirus replication in vivo. C. Hergersberg. Thermo Fisher Scientific. J. Mousa, D. Diaz, J. Crabtree, A. Pena-Briseno, 4:35 Thymic selection of soldiers and peacekeepers. Y. Bar-Peled and R.A. Tripp. Univ. of Georgia. K.A. Hogquist. Univ. of Minnesota Ctr. for (198.1) Immunology. 4:00 Uncharted territory: the CD4+ T cell response to human metapneumovirus. K.D. Lamens, M.C. Rogers, 114. DISTINGUISHED LECTURE J.T. Tometich, T.W. Hand and J.V. Williams. BRUCE R. BLAZAR Univ. of Pittsburgh Sch. of Med. and Vanderbilt Univ. Sch. of Med. (198.2) Distinguished Lecture 4:15 Respiratory syncytial virus strains differentially activate SAT. 6:00 PM—BALLROOM 20BCD the inflammasome eliciting a pathogenic Th17 response. K. Waldstein, K.A. Weiss, S. Hartwig, CHAIR: D. MASOPUST H. Quick, B. Poudel, P. Gurung and S.M. Varga. 6:00 Stem cell transplantation: restoring immune balance. Univ. of Iowa. (198.3) B.R. Blazar. Univ. of Minnesota. 4:30 Relative timing of type I interferon response and virus replication determines disease outcome during respiratory virus infection. R. Channappanavar, A. Fehr, J. Zheng, J. Abrahante, M. Mack, REMINDER D. Meyerholz and S. Perlman. The Univ. of Tennessee Hlth. Sci. Ctr., Univ. of Kansas, Carver Col. of Med. Univ. of Iowa, Univ. of Minnesota, Univ. of Regensburg, Bavaria and Univ. of Iowa. (198.4) 4:45 Can age-associated B cells contribute to anti-viral immunity? O.A. Kugler-Umana, Y. Kuang, W. Zhang, P. Devarajan, J. Xia and S.L. Swain. Univ. of Massachusetts Med. Sch. (198.5) 5:00 Eosinophils undergo temporally regulated phenotypic and physiologic changes during influenza A virus infection. A. Samarasinghe, M. Tiwary and K. LeMessurier. Univ. of Tennessee Hlth. Sci. Ctr. (198.6)

55 SATURDAY—POSTER SESSIONS SATURDAY POSTER SESSIONS

Posters on Display: 9:30 am – 4:30 pm Author Presentation Time: 2:30 pm – 3:45 pm

115. BASIC AUTOIMMUNITY: T CELLS P311 115.12 Critical role of STAT5 tetramerization in the pathogenesis of experimental autoimmune Poster Session encephalomyelitis: a murine model of multiple sclerosis. SAT. 2:30 PM—EXHIBIT/POSTER HALL K.L. Monaghan, B.Y. Farris, C.D. Amend, J. Lin, W.J. Leonard and E.C.K. Wan. West Virginia Univ. and P300 115.1 IL-23 is essential for the switching between NHLBI, NIH. Tfh-IFN-g and Tfh-IL-17 in lupus. H. Hong, Q. Wu, P. Yang, P312 115.13 Regulation of T follicular cell development by B. Luo, J. Li, H. Li, D.J. Cua, H-C. Hsu and J.D. Mountz. Univ. E3 ubiquitin ligase CBL-B in systemic lupus erythematosus. of Alabama, Birmingham, St. John’s Episcopal Hosp., Harvard S. Tu, R. Tang, H. Guo, Q.J. Liu and J. Zhang. Carver Col. of Med. Sch. and Merck Res. Lab. Med., Univ. of Iowa and Ohio State Univ. P301 115.2 The pathogenic role of stem cell-like memory P313 115.14 One size does not fit all: SLAM-associated T cells in rheumatoid arthritis. Y-J. Lee, M. Kim and E.B. Lee. protein is dispensable for type 1 diabetes but required for Seoul Natl. Univ. Col. of Med., South Korea. autoantibody-mediated arthritis. R. Bonami, L. Nyhoff, P302 115.3 Antigen-presenting cells from naive mice C. Hulbert, J. Felton, P.L. Kendall and J.W. Thomas. constitutively present the T cell epitope of SERCA2a and Vanderbilt Univ. Med. Ctr. induce inflammatory cytokine production in antigen-specific P314 115.15 T cells from NOD-PerIg mice transfer neuritis T cells. R. Arumugam, B. Yalaka, C. Massilamany, S. Ali, to NOD-scid mice. J.J. Racine, H.D. Chapman, R. Doty and J-J. Riethoven, X. Sun and J. Reddy. Univ. of Nebraska, D.V. Serreze. Jackson Lab. Lincoln. P315 115.16 NKG2D signaling within the pancreas P303 115.4 Biomarker discovery in pre-type 1 diabetes; decreases NOD diabetes by enhancing CD8+ central Th40 cells as a predictive risk factor. G. Vaitaitis, D. Waid memory T cell formation. M.A. Markiewicz, A.P. Trembath, and D.H. Wagner. Univ. of Colorado Anschutz Med. Campus. N. Sharma and C.E. Mathews. Univ. of Kansas Med. Ctr. and P304 115.5 Novel H2-K and H2-D knockout NOD mice to Univ. of Florida. dissect independent contributions of common MHC I P316 115.17 WITHDRAWN molecules to type 1 diabetes development. J.J. Racine, P317 115.18 Distinct waves of CD8 T cell affinity during I. Stewart and D.V. Serreze. Jackson Lab. demyelinating disease progression. J.R. Jacobs, P305 115.6 Rab4A inactivation in T cells blocks mTOR L. Blanchfield, B. Liu and B.D. Evavold. Univ. of Utah activation, pro-inflammatory lineage development, and Sch. of Med. and Benaroya Res. Inst. disease pathogenesis in lupus-prone mice. N. Huang, P318 115.19 Thpok suppresses pathogenic cytokine B. Wyman, E. Cravo, T. Winans, G. Choudhary, Z. Oaks, production by Th17 cells in autoimmune disease. M. Duarte, J. Lewis, Z-W. Lai, K. Banki and A. Perl. State K.E. Marks, S. Flaherty and J.M. Reynolds. Chicago Med. Univ. of New York Upstate Med. Univ. Sch., Rosalind Franklin Univ. of Med. and Sci. P306 115.7 Lymphocytes populations in murine models of P320 115.20 Single-cell transcriptome analysis reveals systemic lupus erythematosus exhibit different responses to diverse islet-infiltrating T cell subsets and a role for BATF in treatment with metabolic modulators. C. Cornaby, L. Zeumer- promoting the diabetogenic activity of CD8 T cells. Spataro, S-C. Choi, W. Li and L. Morel. Univ. of Florida. A.E. Ciecko, D.M. Schauder, B.M. Foda, C-W. Lin, W. Cui P307 115.8 Nfkbid overexpression in NOD mice elicits and Y-G. Chen. Med. Col. of Wisconsin and Blood Res. Inst. complete type 1 diabetes resistance. J.R. Dwyer, P321 115.21 Understanding how AKT phosphorylation of J.J. Racine, A. Quinlan, M. Presa, H.D. Chapman and hnRNPA1 modulates T cell fate and function. T.L. White, D.V. Serreze. Jackson Lab. M. Gable, Y. Jin and P. Morel. Univ. of Pittsburgh. P308 115.9 CNS-specific autoregulatory CD8 T cells rely P322 115.22 Pathogenic follicular CD8 T cells acquire on IFNg signaling for optimal suppression of pathogenic CD4 diverse function during autoimmune disease. T cell responses during inhibition of demyelinating disease. K.M. Valentine, G.N. Mullins, T.J. Lawrence and A. Boyden, A.A. Brate, L.G. Laageide and N.J. Karandikar. K.K. Hoyer. Univ. of California, Merced and Oak Ridge Natl. Univ. of Iowa Hlth. Care. Lab. P309 115.10 Oct1 and OCA-B in T cells are potent P323 115.23 Micromanaging lupus nephritis: miR-17 therapeutic targets for autoimmune diseases. H. Kim, modulates T development and regulatory T cell activity. A. Shakya, L. Dickey, C. Stone, T. Lane, M.A. Williams FH H-Y. Yang, D. Pardoll and C-Y. Wu. Chang Gung Mem. and D.R. Tantin. Huntsman Cancer Inst., Univ. of Utah and Hosp. and Johns Hopkins Univ. Sch. of Med. Univ. of Utah Sch. of Med. P319 115.24 Tryptamine treatment results in the P310 115.11 Comprehending the phenotypic and functional amelioration of EAE by inducing an anti-inflammatory shift in diversity of gd T cell subtypes in autoimmune skin disease the Th17/Treg balance mediated by regulation of miRNA pemphigus vulgaris. D. Das, S. KV, A. Sharma and S. Arava. expression profile. N. Dopkins, P. Nagarkatti and All India Inst. of Med. Sci., New Delhi, India. M. Nagarkatti. Univ. of South Carolina Sch. of Med.

56 SATURDAY—POSTER SESSIONS

P324 115.25 Age-associated changes in central T cell P339 116.14 The role of microRNA-22 in the dysregulation tolerance induction. S. Cepeda, A.K. Hester, X. Yangming, of lupus Tregs and the pathogenesis of systemic lupus E.B. Kraig and A.V. Griffith. Univ. of Texas Hlth. at San erythematosus. B. Appleton, A.W. Faust, D.L. Michell, Antonio. M.J. Ormseth, K.C. Vickers and A.S. Major. Vanderbilt Univ. and Vanderbilt Univ. Med. Ctr. 116. BASIC AUTOIMMUNITY: IMMUNOREGULATION P340 116.15 Regulation of FOXP3 expression by c-Rel O- GlcNAcylation. T.J. de Jesus, J. Tomalka, S. Shukla, Poster Session F. Staback, R. Agarwal, J. Centore and SAT. 2:30 PM—EXHIBIT/POSTER HALL P. Ramakrishnan. Case Western Reserve Univ. P341 116.16 Activation of naive CD4+CD25+FOXP3+Treg P325 116.1 Resistant effect of sodium chloride on the by specific autoantigen and Th2 cytokines IL-4 and IL-5 + + development and function of TGF-b-induced CD4 Foxp3 induces autoantigen specific Treg that inhibit EAE. regulatory T cells. S.G. Zheng, Y. Luo and J. Wang. B.M. Hall, G. Tran, N.D. Verma, C.M. Robinson, P. Wilcox Pennsylvania State Univ. Col. of Med. and S.J. Hodgkinson. Univ. of New South Wales, Australia P326 116.2 sCD83 alleviates experimental autoimmune and Sydney Univ., Australia. uveitis through disrupting the regulation of Rab1a/LRRK2 on P338 116.17 Agonist-induced 4-1BB activation ameliorates F-actin rearrangements. W. Lin. Shandong Acad. of Med. Sci., the pathogenesis of Sjogren¨ ’s syndrome-like sialadenitis in S China. non-obese diabetic mice. J. Zhou, B. Yoo and Q. Yu. A P327 116.3 CD300c is a negative regulator of T cell Forsyth Inst. immunity. L. Lai, C. Cui, M. Su and Y. Lin. Univ. of T Connecticut. 117. I’M ON FIRE: LOCAL CONTROL OF P328 116.4 Overexpression of Pbx1-d, a novel splice isoform of Pbx1 associated with lupus susceptibility, TISSUE INFLAMMATION regulates regulatory T cell plasticity. S-C. Choi, C. Cornaby Poster Session and L. Morel. Univ. of Florida. — P329 116.5 The cellular basis of the PD-1/PD-L1 SAT. 2:30 PM EXHIBIT/POSTER HALL regulatory pathway in diabetic autoimmunity in the NOD P342 117.1 Type 1 alveolar epithelial cell-derived mouse. H. Hu, X. Wan, P. Zakharov and E.R. Unanue. chemokine CCL19 promotes airway inflammation. Washington Univ. Sch. of Med. H. Nakano, M. Lyons-Cohen, K. Nakano, T. Karcz, P330 116.6 Essential role of IL-17A in Tregs induction in S.Y. Thomas, G. Whitehead and D.N. Cook. NIEHS, NIH. autoimmune uveitis. W.P. Chong, Y. Zhong, M. Mattapallil, P343 117.2 In vivo imaging of caspase-1 activation J. Chen and R.R. Caspi. Sun Yat-sen Univ., China and NEI, enables efficient and rapid detection of various inflammatory NIH. disorders. J. Lee, Y. Ko, E. Yang, N. Jang, H.S. Kim, P331 116.7 Role of Jmjd6 in Aire expression and self- I.C. Kwon and N-H. Cho. Seoul Natl. Univ. Col. of Med., tolerance induction in the thymus. K. Matsubara and South Korea and Korea Inst. of Sci. and Technol., South Korea. Y. Fukui. Med. Institute of Bioregulation, Kyushu Univ., Japan. P344 117.3 Loss of local innervation induces lymph node P332 116.8 Type-1 interferons inhibition of interleukin-10 expansion. C-S. Chen, L. Ince, A. de Juan and signaling in T cells in type 1 diabetes development. M. Iglesias C. Scheiermann. Ludwig-Maximilians-Universitat¨ Munchen,¨ Lozano, M. Chicco, D. Bibicheff, G. Brandacher and Germany, Univ. of Geneva Med. Sch., Switzerland and G. Raimondi. Johns Hopkins Univ. Sch. of Med. Curie Inst., France. P332 116.9 The absence of CD137 ligand upregulates the P345 117.4 Peripherally induced tissue resident memory expression of the immunosuppressive molecule soluble CD8 T cells in the brain mediate protection against CNS CD137. B.M. Foda, M.H. Forsberg, A.E. Ciecko, infections. S.L. Urban, I.J. Jensen, L.L. Pewe, K.W. Mueller, A. Geurts and Y-G. Chen. Med. Col. of V.P. Badovinac and J.T. Harty. Univ. of Iowa Carver Col. Wisconsin. of Med. P334 116.10 Keratinocyte-derived TGF-b is dispensable in P346 117.5 The anti-inflammatory effects of the skin autoimmunity in mice. Y. Yang, Y. Zenke, T. Hirai and Chromogranin A hormone cleavage product catestatin on D.H. Kaplan. Univ. of Pittsburgh. human monocytes and macrophages. E.M. Muntjewerff, P335 116.11 Adenosine: adenosine receptor axis in blood G. Christoffersson, M.J.T. Nicolasen, S.K. Mahata and brain barrier permeability regulation. M.S. Bynoe. Cornell Univ. G. van den Bogaart. Radboud Inst. for Molec. Life Sci., Vet. Med. Col. The Netherlands, Uppsala Univ., Sweden, VA San Diego P336 116.12 AID deficiency greatly improves survival and Healthcare Syst. and Univ. of Groningen, The Netherlands. diminishes renal pathology in the BXSB mouse model of SLE. P347 117.6 Comparing docosahexaenoic acid as a C.M. Leeth, J. Zhu, A. Potter, M. Hasham, M. Richwine and prophylactic treatment for acute and chronic particle- D.C. Roopenian. Virginia Polytechnic Inst. and State Univ. and exposed Balb/c mice. P. Fletcher, R.F. Hamilton, Jackson Lab. M. Buford, B. Postma, J.J. Pestka and A. Holian. Univ. of P337 116.13 A Treg-specific deletion of Helios causes Montana and Michigan State Univ. autoimmune lipodystrophy and metabolic syndrome. P348 117.7 Sex-differences in the response to inhaled A.M. Thornton, O.F. Gavrilova, V.R. Penna, P.E. Korty nanoparticles. J. Ray and A. Holian. Univ. of Montana. and E.M. Shevach. NIAD, NIH and NIDDK, NIH. P349 117.8 BAFF and VCAM-1 cooperate on the interaction between B lymphocytes and fibroblast-like synoviocytes. E.Y. Moon and S.S. Yoon. Sejong Univ., South Korea.

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P350 117.9 EGF-like repeats and discoidin I-like domain 3 P363 117.22 Sargassum horneri mitigates particulate matter deficiency improves post-myocardial infarction healing via induced inflammatory response in MLE-12 cells via MAPK neutrophil extracellular traps mediated pro-inflammatory pathways. S.P. Mihindukulasooriya, K.H.I.N.M. Herath, macrophage polarization. X. Wei, C. Zhang, Z. Xie, A. Kim, H.J. Kim, M-O. Ko, Y-J. Jeon and J. Youngheun. X. Teng, Z. Wang, H. Zheng, S. Zou, N. Huang, K. Cui Jeju Natl. Univ. and J. Li. West China Hosp., Sichuan Univ., China and P364 117.23 CCR2 mediates transendothelial migration of Univ. of Michigan, Ann Arbor. human pathogenic Th17 cells. F. Parween, N. Kathuria, P351 117.10 b-Catenin negatively regulates IL-6 and IL-8 H. Zhang and J.M. Farber. NIAID, NIH. expression at transcriptional level and induces reactivity in P365 117.24 The function of CD83 in HSV-induced Behcet’s human astrocytes. K. Robinson, S. Narasipura and L. Al- disease mouse model. S. Sohn, S.M.S. Islam and H-O. Byun. Harthi. Rush Univ. Med. Ctr. Ajou Univ., South Korea. P352 117.11 Evaluating cooperative roles for STAT3 and P366 117.25 Intrinsic alteration of differentiation and Aiolos in lymphocyte mimicry associated with metastatic glycolysis in T lymphocytes immediately after TCR activation disease. S. Sandhu, K. Read, D. Jones, S. Dickerson and through PSGL-1 signaling. J.L. Hope, D. Otero, P. de Jong, K.J. Oestreich. Virginia Tech Carilion Sch. of Med. and J. Ma, M. Henriquez, G. Powis and L. Bradley. Sanford Virginia-Maryland Col. of Vet. Med. Burnham Prebys Med. Discovery Inst. P353 117.12 Phosphorylation of CBP by IKKa links intestinal homeostasis. S-C. Miaw, Y-T. Lin, Y-H. Hsu, 118. HEMATOPOIESIS AND C. Liu, C-C. Chen, C-T. Shun, C-H. Tu, J-S. Yu, M-S. Wu MYELOID DEVELOPMENT and C-C. Chen. Natl. Taiwan Univ. Col. of Med., Taiwan and Natl. Taiwan Univ. Hosp., Taiwan. Poster Session fl P354 117.13 Neuroin ammation functionally regulates CNS SAT. 2:30 PM—EXHIBIT/POSTER HALL lymphatic vasculature and drainage. M. Hsu, A. Rayasam, “ ” J.A. Kijak, Y.H. Choi, J.S. Harding, S.A. Marcus, P400 118.1 Characterizing a critical window of immune W.J. Karpus, M. Sandor and Z. Fabry. Univ. of Wisconsin, development: how perturbation of developmental Madison, Univ. of California, San Francisco and Mount Sinai hematopoiesis shapes immune function and susceptibility to Hosp., Toronto, Canada. disease in offspring. A.E. Beaudin, D.A. Lopez, A. Apostol, P355 117.14 Inflammasome activation in macrophages is G.E. Hernandez and C. Forsberg. Univ. of California, Merced, regulated by actin-bundling protein L-plastin. H. Joshi, Univ. of California, Los Angeles and Univ. of California, Santa B.E. Todd, T. Szasz, E. Anaya and S.C. Morley. Cruz. Washington Univ. Sch. of Med. P371 118.2 IL-27 receptor signaling potentiates P356 117.15 Analysis of leukocyte populations and nerves angiotensin II induced myelopoiesis and promotes in developing murine corneas. A. Abou-Slaybi, A. Jamali, abdominal aortic aneurysm. T. Aghayev, I. Peshkova, D.L. Harris, Y. Seyed-Razavi and P. Hamrah. Sackler Sch. of A. Fatkhullina, P. Makhov, S. Eguchi, Y.F. Tan, Grad. Biomed. Sci., Tufts Univ. and Tufts Med. Ctr. A. Kossenkov, S. Sykes and E. Koltsova. Fox Chase P357 117.16 Targeted expansion of tissue-resident CD8+ Cancer Ctr., Lewis Katz Sch. of Med., Temple Univ. and T cells to boost cellular immunity in the skin. S.J. Hobbs The Wistar Inst. and J.C. Nolz. Oregon Hlth. and Sci. Univ. P376 118.3 Trauma induces emergency hematopoiesis P358 117.17 Choline acetyltransferase-expressing T cells through IL-1/MyD88-dependent production of G-CSF. are required to control chronic viral infection. M.A. Cox and A.G. Fuchs, D. Monlish, S. Ghosh, S-W. Chang, T. Mak. Princess Margaret Cancer Ctr. G.V. Bochicchio, L.G. Schuettpelz and I.R. Turnbull. P359 117.18 Modulation of liver protein sialylation drives Washington Univ. Sch. of Med. fi spontaneous generation of fatty liver and modulates multiple P377 118.4 Identi cation of splenic progenitors for CD11b inflammatory models. D.M. Oswald, M.B. Jones and high myeloid cells in the long-term culture with GM-CSF. B.A. Cobb. Case Western Reserve Univ. Sch. of Med. S.H. Ryu, H.Y. Na, M. Sohn, W. Choi, H. In, H.S. Shin, P360 117.19 Systemic lupus erythematosus patients’ J.S. Park and C.G. Park. Yonsei Univ. Col. of Med., South peripheral blood mononuclear cells display an altered Korea. transcript isoform repertoire. P. Singh, D. Troggian Veiga, P378 118.5 CCCTC-binding factor regulates the R. Rossi, R. Marches, D. Nehar-Belaid, V. Pascual and development and function of dendritic cells. B. Yang, J. Banchereau. Jackson Lab. for Genomic Med. and Gale T-G. Kim, S. Kim and H-P. Kim. Yonsei Univ. Col. of Med., and Ira Drukier Inst. for Children’s Hlth. South Korea. P361 117.20 The impact of the TRPM2 ion channel on P379 118.6 Acute and chronic waves of myeloid cell inflammation and macrophage metabolism in gastrointestinal maturation and myelopoiesis with high fat diet. E. Bowers, models. H.M.S. Algood, B.R.E.A. Dixon, D. Olivares- S. Abrishami and D. Singer. Univ. of Michigan. Villagomez, C.H. Serezani, M.K. Washington, P374 118.7 Reduced expression of the DNA-binding J.C. Rathmell and L.A. Coburn. Vanderbilt Univ. Med. Ctr. protein ARID3a, a mediator of human hematopoiesis, in P362 117.21 Mycobacterium avium subspecies hematopoietic progenitors contributes to age-related paratuberculosis (MAP) drives an innate Th17-like T cell transcriptional changes. M. Ratliff, J.W. Garton, response and upregulation of inhibitory signals. J.A. James and C. Webb. Univ. of Oklahoma Hlth. Sci. Ctr. J.L. DeKuiper and P.M. Coussens. Michigan State Univ. and Oklahoma Med. Res. Fndn.

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P372 118.8 The DNA-binding protein ARID3a is required P410 119.2 Is absence of acute inflammatory diseases a for human erythrocyte lineage differentiation using the K562 hallmark of chronic conditions? A clinical investigation into model cell line. J.W. Garton, B. Chapman, M. Shankar, asthma patients’ case histories. S. Mahesh, M. Mallappa, K. Rose and C. Webb. Univ. of Oklahoma Hlth. Sci. Ctr. D. Tsintzas and G. Vithoulkas. International Acad. of and Univ. of Central Oklahoma. Classical Homeopathy, Greece. P367 118.9 An Nfil3-Zeb2-Id2 pathway imposes Irf8 P428 119.3 Induced hyperglycemia promotes sensitization enhancer switching during cDC1 development. P. Bagadia. and exacerbates allergic inflammation in a mouse model of Washington Univ. Sch. of Med. in St. Louis. asthma. A. Queener, B.M. Jeong, T.C. Doan, S.E. Chiarella, P368 118.10 Plasma cells are obligate enhancers of age- M.T. Walker, M.E. Coden, R. Nagasaka and S. Berdnikovs. associated myeloid skewing. P. Pioli, D. Casero, Northwestern Univ. E. Montecino-Rodriguez, S.L. Morrison and P427 119.4 Sox9 deletion in the intestinal epithelium K.A. Dorshkind. Univ. of California, Los Angeles. increases house dust mite induced allergic asthma P369 118.11 Merocytic dendritic cell: a new subset of symptoms in mice. M.R. Joldrichsen, E. Kim, Z. Attia, conventional dendritic cells. C. Audiger and S. Lesage. I.C. Davis, E. Comet-Boyaka and P.N. Boyaka. The Ohio Univ. of Montreal, Canada. State Univ. P370 118.12 Histone Deacetylase 3 regulates the ontogeny P405 119.5 FLX193: a potent, selective CCR4 antagonist and maintenance of tissue-resident macrophages. Y. Yao, for allergic disorders. A. Jorapur, L. Marshall, D. Bradford, S Q. Liu, F. Geissmann, L. Zhou and Q-S. Mi. Henry Ford M. Brovarney, D. Chian, A. Wadsworth, J. Sanchez, A Hlth. Sys. and Mem. Sloan Kettering Cancer Ctr. S. Jacobson, E. Karbarz, O. Robles, A. Younai, T P373 118.13 IL7R regulates fetal tissue resident J. Ketcham, A. Ng, P. Tivitmahaisoon, D. Pookot, macrophage development. G. Leung, T. McCann, S. Marubayashi, N. Kozon, C. Colas, A. Okal, G. Cutler, C.H. Valencia, A. Worthington, C. Forsberg and D. Wustrow, J. Schwarz, O. Talay, D. Brockstedt and A.E. Beaudin. Univ. of California, Merced and Univ. of B. Wong. Flxbio, Inc. California, Santa Cruz. P422 119.6 Contribution of protein arginine P375 118.14 Bone marrow resident Tregs maintain stromal methyltransferase (PRMT)5 to house dust mite asthma. cell function via IL-10. V. Camacho, S. Patel, V. Matkins, M. Guerau-De-Arellano, S. Sengupta, S. Amici, L. Webb, H.R. Turnquist and R.S. Welner. Univ. of Alabama, K. Weiss and K. Asosingh. Col. of Med., Ohio State Univ., Birmingham and Univ. of Pittsburgh Sch. of Med. Ohio State Univ. and Cleveland Clin. P401 118.15 Protein kinase C activates multiple pathways to P430 119.7 Treatment with benign IgE reduces asthma induce dendritic cell differentiation. C.A. Chavel and K.P. Lee. symptomology in a mast cell dependent manner. R. Martin, Roswell Park Cancer Inst. M.P. Zellner, J.C. Lownik and A.J. Luker. Virginia P403 118.16 Sclerostin depletion may induce inflammation Commonwealth Univ. in the bone marrow. C. Donham, G. Loots and J. Manilay. P431 119.8 Rifampicin ameliorates inflammatory Univ. of California, Merced. responses in asthma experimental animal model. T.J. Kang, P402 118.17 Metabolic pathways that mediate expansion J.W. Park, A.V. Prakash, K-J. Boo, Y.R. Kim and and homeostasis of hematopoietic lineages. H.A. Pizzato, J-w. Seong. Institue of Chronic Dis., Col. of Pharmacy, W.Y. Lam, B.N. Finck, M.J. Wolfgang and Sahmyook Univ. D. Bhattacharya. Washington Univ., St. Louis and Johns P434 119.9 Poly(ADP)ribose polymerase inhibition by Hopkins Univ. gene knockout or pharmacologically by olaparib restores P404 118.18 Isthmin 1 identifies a subset of lung steroid sensitivity in murine model of steroid-resistant hematopoietic stem cells and it is associated with systemic asthma. M.A. Ghonim, J. Wang, S.V. Ibba, H. Luu and inflammation. G. Rivera-Torruco, C.A. Mendiola, T. Angeles H. Boulares. Louisiana State Univ. Hlth. Sci. Ctr. Floriano, R. Franco, I. Parra-Ortega, A. Vilchis, P432 119.10 Sargassum horneri ethanol extract down- J. Maravillas-Montero, R. Garc´ıa-Contreras, O. Medina regulates the Th2 polarization via STAT5 in ovalbumin Contreras, P. Nava, V. Ortiz-Navarrete, P. Licona-Limon sensitized murine splenocytes. S.P. Mihindukulasooriya, and R. Valle-Rios. CINVESTAV-IPN, Mexico, Hosp. Infantil de K.H.I.N.M. Herath, A. Kim, H.J. Kim, M-O. Ko, Y-J. Jeon Mexico´ Federico Gomez,´ Mexico, Instituto Nacional de and J. Youngheun. Jeju Natl. Univ. Rehabilitacion´ Luis Guillermo Ibarra, Mexico, UNAM, P425 119.11 Bacillus subtilis-mediated suppression of Mexico, Facultad de Medicina, UNAM, Mexico and Instituto house dust mite allergic airway inflammation. de Fisiolog´ıa Celular, UNAM, Mexico. J.A. Swartzendruber, O. Negris, R. Incrocci and K.L. Knight. Midwestern Univ. and Loyola Univ. Med. Ctr. 119. IMMUNITY OF ASTHMA P424 119.12 Glucocorticoids control allergic inflammation via Foxp3+regulatory T cells. Q.T. Nguyen and B. Min. Poster Session Cleveland Clin. Fndn. SAT. 2:30 PM—EXHIBIT/POSTER HALL P411 119.13 IL-9-secreting tissue-resident memory CD4+ T cells contribute to allergic airway recall responses. P413 119.1 Combined immune and airway epithelial cell B.J. Ulrich, Y. Fu, B. Koh, R. Kharwadkar and fi fi pro les de ne asthma severity phenotypes. T.B. Oriss, M.H. Kaplan. Indiana Univ. Sch. of Med. X. Zhou, M. Camiolo, K.L. Scholl, M. Gorry, M. Gauthier, P418 119.14 WITHDRAWN P. Ray, S.E. Wenzel, K.C. Nadeau and A. Ray. Univ. of Pittsburgh Sch. of Med. and Stanford Univ.

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P420 119.15 The transcriptional repressor Blimp-1 P414 119.28 Critical role for IL-33 in orchestrating group 2 promotes Th2 development and lung inflammatory disease innate lymphoid cell and natural killer cell function in the lungs. in a house dust mite-induced model of allergic asthma. M.M. Ferrini, Z. Jaffar and K. Roberts. Univ. of Montana. A.C. Poholek, A. Hettinga, K. He, S. Kale, E. Schmitz, P419 119.29 IL-9high GATA3low ILC2s are potent inducers of S. Pandya, M.M. Xie, A. Dent, T.B. Oriss and A. Ray. allergic airway inflammation. P. Schmitt, A. Duval, S. Roga, Univ. of Pittsburgh Sch. of Med. and Indiana Univ., Purdue M. Camus, O. Burlet-Schiltz, A. Gonzalez-de-Peredo, Univ. Indianapolis. C. Cayrol and J-P. Girard. Institut de Pharmacologie et de P429 119.16 Metabolic differences between Th2 and Th17 Biologie Structurale, France. cells in airway inflammation. D.C. Contreras, J. Cephus, P416 119.30 Allergic lung inflammation in offspring of D. Newcomb and J.C. Rathmell. Vanderbilt Univ. Med. Ctr. pregnant mice exposed to organic dust. P433 119.17 Inhibition of allergen-specific tissue resident A.A.N. Nascimento, D. Schneberger, S. Kirychuk, memory Th2 cells through blockade of CD3-mediated U. Pandher, B. Thompson and B. Singh. Univ. of signaling ameliorates allergic lung inflammation. Saskatchewan, Canada and Univ. of Calgary, Canada. D.T. Gracias, R.K. Gupta and M. Croft. La Jolla Inst. for P435 119.31 APD588, a novel, selective S1P receptor Immunology. modulator, inhibits inflammation and airway P421 119.18 Endogenous UDP-Glc acts through the hyperresponsiveness in the ovalbumin-induced model of purinergic receptor P2RY14 to exacerbate eosinophilia and allergic asthma. C.M. Crosby, H.K. Komori, airway hyperresponsiveness in a protease model of allergic R. Christopher and J.W. Adams. Arena Pharmaceuticals asthma. T. Karcz, G. Whitehead, H. Nakano, K.A. Jacobson and Parallel 33 Consulting. and D.N. Cook. NIEHS, NIH and NIDDK, NIH. P426 119.19 Inhibiting host DNA release prevents mixed 120. HUMAN HOST DEFENSE neutrophilic/eosinophilic airway inflammation in severe asthma phenotype. S. Chung, M. Karpurapu and Poster Session J.W. Christman. The Ohio State Univ. SAT. 2:30 PM—EXHIBIT/POSTER HALL P406 119.20 Clearance of apoptotic cells by lung macrophages prevents development of house dust mite- P436 120.1 Anti-CD4 autoantibody-mediated failure of induced asthmatic lung inflammation. H. Miki, D.T. Gracias CD4+ T cell reconstitution in HIV-infected patients under and M. Croft. La Jolla Inst. for Allergy and Immunology. viral-suppressive ART. W. Jiang and Z. Luo. Med. Univ. of P415 119.21 The complex allergen house dust mite acts South Carolina. directly on macrophages to stimulate noncanonical P437 120.2 Neutrophils contribute to T cell activation via autophagy. H. Gao, X. Qi, W. Jackson and A. Keegan. reactive oxygen species production in HIV infection. Univ. of Maryland Sch. of Med. G.J. Dunsmore, S. Shahbaz, S. Houston and S. Elahi. P409 119.22 OPN receptor expression on immune effector Univ. of Alberta, Canada. cells in RSV infection is regulated by NKT cells. M.H. Qureshi, P438 120.3 Functional impact of a cellular long non-coding O. Qureshi and K. Durre. California Hlth. Sci. Univ. Col. of RNA on CCR5 expression and HIV infection. S. Kulkarni, Osteo. Med., Yale Col. and Touro Univ. of Nevada Col. of A. Lied, V. Kulkarni, S. singh, M. Rucevic, M.P. Martin, Osteo. Med. F. Chawdhury, S. Le Gall, X. Yu and M. Carrington. Texas P407 119.23 Ly-6C+CD11b+ conventional dendritic cells Biomed. Res. Inst., Ragon Inst. of MGH, MIT and Harvard and accumulate in inflamed lung and differentiate into type 2 NCI, NIH. dendritic cells. G. Izumi, K. Nakano, S.Y. Thomas, P439 120.4 Loss of testosterone impairs anti-tumor G. Whitehead, S.A. Grimm, H. Nakano and D.N. Cook. neutrophil function. J. Markman, D. Wakita, R.A. Porritt, NIEHS, NIH. E. Posadas, T.R. Crother and M. Arditi. Cedars-Sinai P412 119.24 Effect of different adjuvants on various immune Med. Ctr. cells and cytokines in allergic asthma mouse model. H.S. Shin, P440 120.5 Role of natural killer cell activity in HIV H.R. Chun, HY. Na, M. Sohn, S.H. Ryu, W. Choi, H. In, infections, aging, and breast cancer survival. R.M. Williams, J.S. Park and C.G. Park. BK21 PLUS Project for Med. Sci., J. Zuniga, J. Granados and E.J. Yunis. Northern California Yonsei Univ. Col. of Med., South Korea and Yonsei Univ., Cancer Ctr. and Res. Institute, Institute of Respiratory Dis., South Korea. Mexico, Inst. of Nutrition, Mexico and Dana Farber Cancer P417 119.25 IRF4 expression by lung dendritic cells drives a Institute, Harvard Med. Sch. Th2 program throughout the effector and memory allergic P441 120.6 Vd1+ and Vd2+ gamma delta T cells express responses. D.F. Camacho, E. Wang, C.L. Howard, different marker signatures and are distinctly linked to plasma fl D.C. Decker, K.M. Blaine, E.P. Darnell, P.A. Krishack, markers of in ammation with ART-suppressed HIV infection C.L. Hrusch, J.J. Moon and A.I. Sperling. Univ. of and normal aging. J.E. Snyder-Cappione, R.M. Pihl, Chicago and Harvard Med. Sch. A.J. Olson, N. Lin and A.C. Belkina. Boston Univ. Sch. of P423 119.26 Impaired tumor-necrosis-factor-a-driven Med. and Boston Med. Ctr. dendritic cell activation limits lipopolysaccharide-induced P442 120.7 Role of Mycobacterium tuberculosis protection from allergic inflammation in infants. K. Kaur, expressing unique protein Rv000B in immune modulation of H. Bachus, A.M. Papillion, T.T. Marquez-Lago, Z. Yu, host cell machinery. S.K. Arora, A. Alam, J. Ahmad, A. Ballesteros-Tato, S. Matalon and B. Leon-Ruiz. Univ. S. Suhasini, N. Naqvi, S.E. Hasnain and N.Z. Ehtesham. of Alabama, Birmingham. JH Inst. of Molecular Med., India and Natl. Inst. of Pathology, P408 119.27 The function of the circulating innate lymphoid India. cells is dysregulated in patients with mild asthma. L.Y. Drake, K. Bachman and H. Kita. Mayo Clin.

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P443 120.8 IL-15 activates liver sinusoidal mucosal- P455 120.20 CD4 T cell transcriptomics reveal novel associated invariant T cells to exert TCR/MR1-independent diagnostic and mechanistic immune signatures of innate-like cytotoxicity. M-S. Rha, J.W. Han, JH. Kim, tuberculosis. J.G. Burel, C.S. Lindestam Arlehamn, J-Y. Koh, H.J. Park, S.I. Kim, M.S. Kim, J.G. Lee, M. Pomaznoy, G. Seumois, J.A. Greenbaum, J.Y. Park, S-H. Park, D.J. Joo and E-C. Shin. Grad. Sch. D. Vidanagama, B. Gunasena, R. Tippalagama, A.D. de of Med. Sci. and Engin., Korea Advanced Inst. of Sci. and Silva, R. Taplitz, P. Vijayanand, A. Sette and B. Peters. Technol., South Korea and Yonsei Univ. Col. of Med., South La Jolla Inst. for Immunology, Natl. Tuberculosis Reference Korea. Lab., Sri Lanka, Natl. Hosp. for Resp. Dis., Sri Lanka, P444 120.9 Serum antibody profiling healthy toddlers Genetech Res. Inst., Sri Lanka and Univ. of California, San reveals low, intermediate and high response cohorts. Diego. N.S. van Oers, P. Pichilingue-Reto, P. Raj, I. Dozmorov, P456 120.21 PPARg deficiency promotes an adaptive T Q-Z. Li, E.K. Wakeland, N. Kelly and M.T. de la Morena. lymphocyte response to mycobacterial antigen ESAT-6 in a Univ. of Texas Southwestern Med. Ctr. and Univ. of murine model of chronic pulmonary sarcoidosis. Washington. V.L. Sanderford, N. Leffler, A. Malur, A. Mohan, P445 120.10 Macrophage heterogeneity correlates with R.A. Barrington, B.P. Barna and M.J. Thomassen. East autophagy-dependent anti-mycobacterial activity and ability Carolina Univ. and Univ. of South Alabama. to present antigen in human macrophages. V.K. Singh, P457 120.22 Resistin immunomodulation in healthy and S A. Khan, R. Papanna, L. Mann, J.H. Wan, D. Canaday, septic patients. J. Li, J. Bonenfant, L. Nasouf, J. Miller, A S.A. David and C. Jagannath. Houston Methodist Res. A. Mittal, W. Klein and M.G. Nair. Univ. of California, T Inst., Univ. of Texas, Houston, Univ. of Texas Hlth. Sci. Ctr., Riverside and Riverside Univ. Hlth. Syst. Houston and Univ. of Minnesota. P458 120.23 Identification of new T cell epitopes in the mold P446 120.11 PET imaging of TSPO in a rat model of sepsis aeroallergen Aspergillus fumigatus. L. Sternberg, induced by peritoneal polymicrobial infection. T. Barichello, G. Seumois, S. Paul, J. Sidney, V.M.J. Schulten, V.V. Giridharan, F. Petronilho, J.S. Generoso, A. Sette, P. Vijayanand and B. Peters. La Jolla Inst. for D. Dominguini and F. Dal-Pizzol. UTHealth, UNISUL, Immunology. Brazil and UNESC, Brazil. P459 120.24 HIV infection drives immune activation of P447 120.12 High T cell percentage predicts improved angiogenic T cells. L. Tong, M. Schmidt, Z. Zhu, J. Chen, overall survival in de novo acute myeloid leukemia. A. Wellstein, J. Kumar, P. Kumar and M. Catalfamo. J.N. Saultz, W. Wang, E.F. Lind, A. Kaempf, G. Fan, Georgetown Univ. Sch. of Med. and Lombardi T. Mori and B. Park. Oregon Hlth. and Sci. Univ. Comprehensive Cancer. P448 120.13 Identification of autophagy markers in clinical P460 120.25 Endoplasmic reticulum stress regulates cases of sepsis. C. Madiraju, C.S. Mallarpu, S. Prasad, immunosuppressive function of myeloid derived suppressor M. Singarapu, H. Brar, N. Bratic, N. Haririparsa, cells in leprosy. K. Kelly-Scumpia, R. Shirazi and R. Modlin. J.H. Kim, M. Ponnana and L.K. Chelluri. Marshall B. Univ. of California, Los Angeles. Ketchum Univ. and Gleneagles Global Hosp., India. P461 120.26 Commensal microbiota as possible pathobiont P449 120.14 Suppressive role on bacterial resistance of in autoinflammatory disease. J. Siak, A. St. Leger, CD10+Pax5+cells in alcohol use disorder patients. K. Raychaudhuri, M. Mattapallil, I.J. Fuss, R. Goldbach- Y. Tsuchimoto, A. Asai, H. Ohama, S. Fukunishi and Mansky, W. Strober and R.R. Caspi. NEI, NIH, Univ. of K. Higuchi. Osaka Med. Col., Japan. Pittsburgh Sch. of Med., NIH and NIAID, NIH. P450 120.15 Evaluation of T regulatory cells responses in P462 120.27 Release of transglutaminase 2 from respiratory acute and chronic phases of Chikungunya patients. B.M. Gois, syncytial virus-infected airway epithelial cells and its role in I.C. Guerra-Gomes, R.F. Peixoto, C.S.N. Dias, disease pathogenesis. Y.M. Hosakote, K. Rayavara and P.H.S. Palmeira, J.M.G. Araujo´ and T. Keesen. Federal A. Kurosky. The Univ. of Texas Med. Br. Univ. of Paraiba, Brazil, Univ. of São Paulo, Brazil and P463 120.28 Modulation of respiratory syncytial virus- Federal Univ. of Rio Grande do Norte, Brazil. induced epithelial proinflammatory mediator HMGB1 via P451 120.16 Clonal expansion within circulating activation of histone deacetylase. K. Rayavara Kempaiah, plasmablast populations lends support for an infectious A. Kurosky and Y.M. Hosakote. Univ. of Texas Med. Br. disease etiology of Kawasaki disease. M. Hicar, P464 120.29 DNA gene expression to study the J. Hoffman, H. Sojar and S. Baron. State Univ. of New immunologic mechanisms for long-term immunity against York, Buffalo. malaria in babies and children in South-Western Nigeria. P452 120.17 URT bacterial microbiota interacted with H1N1 J.T. Thornthwaite, O.E. Akanni, A.A. Ademola and infection by IL-1 pathway in C57BL/6. H. li, Q. Wu, L. Guo, A.A. O.A.T. Cancer Res. Inst. of West Tennessee and N. Li, H. Zheng, H. Li, Z. Yang, X. Huang, J. Yang, M. Chu Ladoke Akintola Univ. of Technol. and L. Liu. Chinese Acad. of Med. Sci. and Peking Union Med. P465 120.30 Skin transcriptomics reveals novel insights into Col., China. pathophysiological mechanisms in humanized mice models of P453 120.18 Antigen-induced production of nine cytokines group A streptococcal necrotizing soft tissue infections. reflects pulmonary tuberculosis severity and predicts patients’ S. Nookala, S. Mukundan, A. Scheidegger, responsiveness to treatment. I.Y. Nikitina, T.A. Nenasheva, G. Ambigapathy, C. Combs and M. Kotb. Univ. of North Y.H.V. Serdyuk, T.R. Bagdasaryan, V.A. Shorokhova and Dakota. I.V. Lyadova. Central Tuberculosis Res. Inst., Russia. P454 120.19 Interleukin-27 enhances the function of regulatory T cells to prevent Graft-versus-host diseases. Visit AAI and the AAI Journals at Booth 1101. T.H.N. Le, B.K. Hamilton and B. Min. Cleveland Clin. Fndn.

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P466 120.31 Eosinophilic esophagitis has a sub-epithelial P478 121.8 Metabolic reprogramming of human pro- regulatory adaptive immune response. E. Lin, A. Lucendo, inflammatory B cells in aging and obesity. B. Blomberg, H. Appelman, D. Delker, M. Hazel, M. Wechsler, M. Yandell A. Diaz, M. Romero and D. Frasca. Univ. Miami Miller Sch. and F. Clayton. Univ. of Utah, Servicio de Salud de Castilla-La of Med. Mancha, Spain, Univ. of Michigan Med. Sch. and Natl. Jewish P479 121.9 Cell-specific inhibition of SMAD2/3 restores Hlth. lymph node cellularity and germinal center function in aged P467 120.32 Chronic HCV infection, HCV/HIV coinfection mice responding to acute chikungunya virus infection. and older age are independently associated with na¨ıve J. Uhrlaub, Y-S.S. Yang, M.B. Melo, D.J. Irvine and CD4+CD31+ lymphopenia. A. Auma, C. Kowal, J. Nikolich-Zugich. Univ. of Arizona and Massachusetts E. Zebrowski, S. Damjanovska, C. Shive, M. Osborne, Inst. of Technol. R. Kalayjian and D.D. Anthony. Case Western Reserve P700 121.10 T follicular helper cell recruitment to the Univ. Sch. of Med., Louis Stokes VHA Med. Ctr. and ischemic brain. L.T. Kissel, A. Rayasam, J. Kijak, MetroHlth. Med. Ctr. Y.H. Choi, M. Hsu, K. Kovacs, M. Sandor and Z. Fabry. P468 120.33 Harnessing single cell analysis to characterize Univ. of Wisconsin, Madison, Univ. of California, San the role of MAIT cells in ulcerative colitis. S.M. Sharma, Francisco, Med. Col. of Wisconsin and Univ. of Wisconsin L. Gioia, B. Abe, M. Holt, A. Costanzo, L. Kain, A. Su Sch. of Med. and Publ. Hlth. and L. Teyton. Scripps Res. Inst. P701 121.11 Induction of T cell-independent hypermutated P469 120.34 Alterations of specific lymphocytic subsets with and protective IgG and IgA antibody responses by TLR4-BCR ageing and with aged-related metabolic and cardiovascular or TLR5-BCR co-engagement. C.E. Rivera, D. Chupp, diseases. C.L. Liu, V.T.N. Tram, C.H. Lin, K.C. Liao and H. Yan, J. IM, J. Wang, H.N. Sanchez, S. Wu, J. Taylor, Y.J. Chen. Sch. of Med. Lab. Sci. and Biotechnology, Taipei H. Zan, Z. Xu and P. Casali. Univ. of Texas Hlth. Sci. Ctr. San Med. Univ., Taiwan and Chang Gung Mem. Hosp., Taiwan. Antonio. P470 120.35 Macrophage-associated lipin-1 enzymatic P702 121.12 B cell-intrinsic and lymphocyte extrinsic miR- activity promotes inflammation in vitro and in vivo. 21 drive optimal germinal center and antibody responses. A.E. Vozenilek and M.D. Woolard. Louisiana State Univ. S.L. Schell, N. Choi and Z.S.M. Rahman. Pennsylvania Hlth. Sci. Ctr. Shreveport. State Univ. Col. of Med. P703 121.13 Clonal selection of cross-reactive memory B 121. B CELLS AND TfH CELLS cells dominates recall responses against heterologous flaviviruses without a requirement for secondary affinity Poster Session maturation. R. Wong, J. Richner, H. Zhao, SAT. 2:30 PM—EXHIBIT/POSTER HALL M.J. Shlomchik, M.S. Diamond and D. Bhattacharya. Washington Univ., St. Louis and Univ. of Pittsburgh. fi P471 121.1 Production of peanut-speci c IgE in a food P704 121.14 B cell anergy: Atheroprotective, yet vulnerable allergy model is promoted by T follicular regulatory cells via to atherosclerotic conditions. T. Waseem, W.C. Keeter, an IL-10-dependent pathway. M.M. Xie, H. Liu, K. Yang and A. Moriarty, S. Edemobi, M. Pham, A. Getahun, A. Dent. Indiana Univ. Sch. of Med. J.C. Cambier and E. Galkina. Eastern Virginia Med. Sch. P472 121.2 How TLR9 signaling shapes the survival, and Univ. of Colorado Anschutz Med. Campus. differentiation and the metabolism of B cells. M. Akkaya, P705 121.15 Dissecting the role of proinflammatory B. Akkaya, B. Theall, J. Traba, M. Pena and S.K. Pierce. chemokine CCL3 in the selection of germinal center B cells NIAID, NIH and NHLBI, NIH. and in secondary antibody responses. I. Grigorova, Z. Benet P473 121.3 Regulation of B-cell-mediated immune and F. Ke. Univ. of Michigan. responses by a PX domain-containing protein. D-J. Jung, P706 121.16 T follicular regulatory cells reduce proliferation G. You, A. Park and Y-M. Kim. Korea Advanced Inst. of and downregulate induction of costimulatory molecules on Sci. and Technol., South Korea and Pohang Univ. of Sci. human Tfh and B cells. I. Sayin, C. Smith, M. Buggert, and Technol., South Korea. M.R. Betts and D.H. Canaday. Case Western Reserve P474 121.4 Interleukin-27-producing B cells are critical Univ., Karolinska Inst., Sweden and Perelman Sch. of Med., regulators of immunity during persistent viral infection. Univ. of Pennsylvania. I. Pratumchai, Z. Huang, J. Zak and J.R. Teijaro. Scripps P707 121.17 Discovery of perforin-expressing killer B cells Res. Inst. in vertebrates. J.O. Sunyer, Y. Shibasaki, F. Takizawa, P475 121.5 Modulation of B cell metabolic activation and M. Gonzalez and P. Boudinot. Univ. of Pennsylvania, cellular function by toll-like receptors. B.P. Theall, T. Henke, Fukui Prefectural Univ., Japan and INRA, Universite´ Paris- B. Akkaya, A. Roesler, J. Traba, A. Sharma, S.K. Pierce and Saclay, France. M. Akkaya. NIAID, NIH and NHLBI, NIH. P476 121.6 Distinct antibody repertoire of cerebral spinal 122. INNATE IMMUNITY AND INFECTIOUS DISEASE fluid B cells from healthy controls. S. Husain-Krautter, D. Vos, J.A. Gallego, A.K. Malhotra and T.L. Rothstein. Delaware Poster Session Psychiatric Ctr., Western Michigan Univ. Homer Stryker MD SAT. 2:30 PM—EXHIBIT/POSTER HALL Sch. of Med., Weill Cornell Med. Col. and Zucker Hillside Hosp. P477 121.7 The surprising role of indoleamine 2,3- P708 122.1 Activated plasmodium-specific CD8 T cells dioxygenase in supporting the survival of bone marrow- find liver stages mostly randomly. V.S. Zenkov. Univ. of resident long-lived plasma cells. S.M. Lightman, Tennessee. L.M. Carlson and K.P. Lee. Roswell Park Cancer Inst.

62 SATURDAY—POSTER SESSIONS

P709 122.2 Upregulation of intestinal tumor growth factor- P721 122.14 Characterizing the movement strategy of b1 is associated with increased intestinal epithelial cell CD8+ T cells in finding malaria parasites in the liver. apoptosis in pathogenic simian immunodeficiency virus V.V. Ganusov, H. Rajakaruna, J. O’Connor, V.S. Zenkov infection. B. Pahar, D. Pan, S. Srivastav and A. Das. and I.A. Cockburn. Univ. of Tennessee and Australian Natl. Tulane Natl. Primate Res. Ctr. and Tulane Univ. Univ., Australia. P710 122.3 The lysophosphatidylcholine transporter, P722 122.15 Dermal fibroblasts control mast cell reactivity to MFSD2A, is essential for CD8+ memory T cell maintenance commensal bacteria. Y-L. Chang, K. Sriram, Z. Wang, and secondary response to infection. L.M. D’Cruz, S. Igawa, C-C. Wu, P. Insel and A. Di Nardo. Sch. of A. Piccirillo, E. Hyzny, A. Menk, C. Wallace, W.F. Hawse, Med., Univ. of California, San Diego. H.M. Buechel, B. Wong, J.C. Foo, A. Cazenave-Gassiot, P723 122.16 Natural killer cell inhibition of HIV vaccine M. Wenk, G.M. Delgoffe, S. Watkins and D. Silver. Univ. of responses. I.E. Gyurova, J.P. McNally, C.E. Rydyznski Pittsburgh, Univ. of Pittsburgh Cancer Inst., National Univ. of and S.N. Waggoner. Cincinnati Children’s Hosp. Med. Ctr. Singapore, Singapore and Univ. of Pittsburgh Cancer Instit. P724 122.17 Allo-specific NK cells differentially regulate P711 122.4 GRK2 regulated CXCR4 expression mediates T cell allo-immunity depending on prenatal education. bone marrow ILC2 mobilization in sepsis. . Shu, D. Lai, H.K. Kang, L. Turner, C. Redden and A.F. Shaaban. Lurie W. Chen, Q. Chen, X. Fang and J. Fan. Zhejiang Univ. Children’s Hosp., Northwestern Univ. Sch. of Med., China. and Univ. of Pittsburgh Sch. of Med. S P712 122.5 PD-1 signaling impacts T cell function during 123. B CELL IMMUNITY A the early phase of infection with Toxoplasma gondii. T J.A. Perry, J. Delong, J. Clark, J. Park, J. Gullicksrud, Poster Session L. Shallberg, C. Konradt, D. Christian and C. Hunter. SAT. 2:30 PM—EXHIBIT/POSTER HALL Univ. of Pennsylvania. P713 122.6 PGAM1 hypomethylation drives aerobic P725 123.1 PU.1 and IRF8 regulate the transcriptional ¨ı glycolysis in CD4 T cells to facilitate the host defense landscapes differently in na ve and activated B cells. against tuberculosis. X. Chen, J. Zhu, C. Zhu, F. Gao and H. Wang, P. Li, J. Lin, J. Oh, S. Bolland, W.J. Leonard Y. Cai. Shenzhen Univ. Sch. of Med., China, Beijing Chest and H.C. Morse. NIAID, NIH and NHLBI, NIH. Hosp., Capital Med. Univ., China and Chinese Acad. of Agr. P726 123.2 Tumor necrosis factor receptor associated Sci., China. factor 3 regulates B cell antigen receptor signaling. P714 122.7 Invariant NKT cells functionally link microbiota- A.L. Whillock and G.A. Bishop. Univ. of Iowa Carver Col. induced butyrate production and joint inflammation. S. Lee, of Med. fi H.Y. Kim and D. Chung. Seoul Natl. Univ. Col. of Med., South P727 123.3 The bona de structure of IgM pentamer and its Korea. binding mode with AIM/CD5L molecule. T. Miyazaki, P715 122.8 T-bet deficiency impairs CD4 T cell effector E. Hiramoto and S. Arai. Univ. of Tokyo, Japan. trafficking to influenza A virus infected lungs but not their anti- P728 123.4 The role of ERK2 in germinal center B cell viral functions. K. Dhume, C. Finn and K.Kai McKinstry. Univ. selection. A.J. Negron, S. Jeffreys, R. Perez, N. Abdul- of Central Florida Col. of Med. Baki and T. Forsthuber. Univ. of Texas, San Antonio. P716 122.9 Effect of malaria pathology on CD4 and P729 123.5 CD209 activation promotes survival of ´ı immune cells. E.C. Amadi, E. Eze and V. Chigor. Enugu lymphoblastic human B cells. A.J. Valentin and G.Y. D az. State Univ. of Science and Technol., Nigeria and Univ. of Universidad Central del Caribe. Nigeria Nsukka, Nigeria. P730 123.6 Effects of antiorthostatic suspension, tetanus P717 122.10 Costimulation of type-2 innate lymphoid cells toxoid, and CpG on the bone marrow antibody repertoire in by GITR promotes effector function and ameliorates type 2 C57BL/6 mice. T.A. Rettig, N.C. Nishiyama, M.J. Pecaut and diabetes. L. Galle, I. Sankaranarayanan, B.P. Hurrell, S.K. Chapes. Loma Linda Univ. and Kansas State Univ. E. Howard, R. Lo, H. Maazi, G. Lewis, H. Banie, P731 123.7 APRIL signaling in human antibody secreting A.L. Epstein, P. Hu, V.K. Rehan, F.D. Gilliland, cells promotes cellular response via p38 and differential H. Allayee, P. Soroosh, A.H. Sharpe and O. Akbari. Univ. immediate early gene regulation. S.J. Stephenson, of Southern California, Janssen Pharmaceutical Co. of M.A. Care, G.M. Doody and R.M. Tooze. Univ. of Leeds, Johnson & Johnson, Harbor-UCLA and Harvard Med. Sch. United Kingdom. P718 122.11 The role of innate immune cells in contact P732 123.8 Epigenetic priming underpins enhanced hypersensitivity. K. On, S. Tikoo, R. Jain and memory B cell differentiation. M.J. Price, C.D. Scharer, W. Weninger. Centenary Inst. of Cancer Med. and Cell A.K. Kania, T. Mi, S.L. Hicks, T.D. Randall and J. Boss. Biol., Australia. Emory Univ. and Univ. of Alabama, Birmingham. P719 122.12 The IL-12/STAT4 pathway associates with P733 123.9 Linking endoplasmic reticular Stress, ELL2, critical functions in neutrophils. W.C. Keeter, A. Moriarty, and alternative splicing. C. Milcarek. Univ. of Pittsburgh K. Ma, L. Glenn, T. Waseem, F. Lattanzio, S. Edemobi, Sch. of Med. J. Nadler, M.H. Kaplan and E. Galkina. Eastern Virginia P734 123.10 Intrinsic function of STAT3 in B cells is to Med. Sch., Easter Virginia Med. Sch. and Indiana Univ. Sch. promote B cell proliferation and maturation. F. Oladipupo, of Med. C.E. Egwuagu, C-R. Yu and J.K. Choi. NEI, NIH. P720 122.13 Infant T cells exhibit increased TCR signaling P735 123.11 CD28 regulates autophagy to enhance plasma and proliferation to respiratory infection. P. Thapa, R.S. Guyer cells survival. P. Peng, C. Chavel, A. Utley, L. Carlson and and D.L. Farber. Columbia Univ. Med. Ctr. K.P. Lee. Roswell Park Cancer Inst.

63 SATURDAY—POSTER SESSIONS

P736 123.12 Inositol polyphosphates promote T cell- P749 124.2 Reciprocal regulation of Th2 and Th17 cells by independent humoral immunity via the regulation of Bruton’s PAD2-mediated citrullination. B. Sun, H-H. Chang, tyrosine kinase. R.H. Seong, W. Kim and H. Min. Sch. of A. Salinger, B. Tomita, M. Bawadekar, M.A. Shelef, Biological Sci., Seoul Natl. Univ., South Korea. E. Weerapana, P.T. Thompson and I-C. Ho. Brigham and P737 123.13 O-GlcNAcylation of c-Myc dynamically Women’s Hosp., Univ. of Massachusetts Med. Sch., Univ. of regulates pre-B cell proliferation. S-K. Park. Korea Res. Wisconsin, Madison and Boston Col. Inst. of Bioscience and Biotechnology, South Korea. P752 124.3 Cellular retinoic acid binding protein 2 serves P739 123.14 Integrative analysis of human memory B cell as a critical regulator in immune regulation and inflammation. coding and non-coding transcriptomes. J.B. Moroney, I. Takazawa, A. Larange and H. Cheroutre. La Jolla Inst. for A. Vasudev, J.R. Taylor, H. Zan, A. Pertsemlidis and Immunology. P. Casali. Univ. of Texas Long Sch. of Med., UTHealth, San P751 124.4 VSTM4 is a novel negative regulator of T cell Antonio. activation. J. Wang, B. Manick, M. Renelt, J. Suin, P740 123.15 TET enzymes augment AID expression via L. Hansen, A. Person, V. Kalabokis and G. Wu. R&D 5hmC modifications at the Aicda superenhancer. Systems, Bio-techne. C-W.J. Lio, V. Shukla, D. Samaniego-Castruita, P753 124.5 IL-1b regulates IL-33-mediated T helper 2- E. Gonzalez Avalos, A. Chakraborty, X. Yue, D.G. Schatz biased immunopathophysiology following respiratory and A. Rao. La Jolla Inst. for Immunology and Yale Univ. Sch. syncytial virus infection in an age-dependent and caspase-1 of Med. independent manner. L.D. Vu, D.T. Siefker, D. You, P741 123.16 Temporal dynamics of the serological J.P. DeVincenzo, A.T.Q. Phan and S.A. Cormier. compartment of rabbit antibody repertoires. A. Patel, Louisiana State Univ. and Louisiana State Univ. Sch. of Vet. S.R. Bonissone and N. Castellana. Digital Proteomics. Med., Univ. of Tennessee Hlth. Sci. Ctr. and Children’s Fndn. P742 123.17 Direct activation of Toll-like receptors induce Res. Inst., Le Bonheur Children’s Hosp. differential B cell responses. A.J. Nelson and Y.L. Wu. Loyola P754 124.6 Novel roles for the Ikaros zinc finger Univ. Chicago. transcription factor Eos in regulating TH2 differentiation. P743 123.18 Physiological V(D)J recombination is mediated M.N. Rasheed, B. Sreekumar, S.C. Moon, M.D. Powell, by RAG scanning of loop-extruded chromatin. Y. Zhang, K. Read and K.J. Oestreich. Virginia Tech Carilion Sch. of X. Zhang, Z. Liang, Z. Ba, E. Dring, J. Zurita, A.P. Aiden, Med. and Biomed. and Vet. Sci. Grad. Program, Virginia- E.L. Aiden and F.W. Alt. Western Michigan Univ. Homer Maryland Col. of Vet. Med. Skryker Sch. of Med., Boston Children’s Hosp. and Baylor P756 124.7 T-cell signaling in Th17-mediated Col. of Med. inflammation. T-H. Tan and H-C. Chuang. Natl. Hlth. Res. P738 123.19 Differential gene expression of the B cell Inst., Taiwan. receptor signaling pathway during pregnancy in mice. P757 124.8 Tbet provides survival advantage to Tregs N.J. Valeff, D. Muzzio, M. Abba, M. Zygmunt and during type 1 inflammation. B. Akkaya, M. Akkaya, J.A. Al F. Jensen. CEFYBO-CONICET, Argentina, Med. Fac., Souz, A.H. Holstein, M. Maz, J. Kabat, O. Kamenyeva and Greifswald Univ., Greifswald, Germany and CINIBA-UNLP, E.M. Shevach. NIAID, NIH, LIG, NIAID, NIH, LISB, NIAID, NIH Argentina. and RTB, NIAID, NIH. P744 123.20 Human plasma cells switch on and turn off P758 124.9 Helios predisposes human fetal CD4+ naive antibody secretion. D.C. Nguyen, C. Saney, A. Ley, I. Sanz T cells toward regulatory T cell differentiation. M. Ng, and F.E-H. Lee. Emory Univ. T. Roth, V. Mendoza, A. Marson and T. Burt. Univ. of P745 123.21 Innate signaling pathways contribute towards California, San Francisco. formation of the extra-follicular B cell response. J. Lam and P759 124.10 Batf promotes and stabilizes Th17 cell N. Baumgarth. Univ. of California, Davis. development by antagonizing the actions of STAT5. P746 123.22 IL-21 is a major suppressor of IgE production in D. Pham, D.J. Silberger, R.D. Hatton and C.T. Weaver. mice and humans. C.D.C. Allen, Z. Yang, C-A.M. Wu and Univ. of Alabama at Birmingham. S. Targ. Univ. of California, San Francisco. P760 124.11 Cooperative roles for Aiolos and STAT3 in P747 123.23 A screening platform for human plasma cells TH17 differentiation. S.C. Moon, B. Sreekumar, reveals a selective response to SYK inhibition. M. Campbell, M.N. Rasheed, K. Read, M.D. Powell and K.J. Oestreich. S.J. Stephenson, K. Whale, S. Rapecki, H. Finney, Carilion Sch. of Med., Virginia Polytechnic Inst. and State G.M. Doody and R.M. Tooze. Univ. of Leeds, United Univ., Virginia Polytechnic Inst. and State Univ. and Virginia- Kingdom and UCB, United Kingdom. Maryland Col. of Vet. Med. P761 124.12 Regulation of Tfh cell development through 124. MOLECULAR MECHANISMS OF HELPER STAT1 signaling. L. Qin, A. Sahoo, Y. Zhao, A. Alekseev T CELL DIFFERENTIATION and R.I. Nurieva. Univ. of Texas MD Anderson Cancer Ctr. P750 124.13 T-bet expression is fine-tuned for balancing Poster Session IFN-g-producing Th1 and Tfh cell differentiation and SAT. 2:30 PM—EXHIBIT/POSTER HALL IgG2a(c) production. D. Fang, M. Zheng, K. Mao, S.L. Reiner, A. Sher and J. Zhu. NIAID, NIH and Columbia P748 124.1 Sumoylation of RORgt regulates TH17 Univ. Med. Ctr. differentiation and thymocyte development. Z. Sun, Z. He, P755 124.14 Transcriptional regulation of IL-10 in T helper J. Zhang, Z. Huang, Q. Du, N. Li, Q. Zhang and Y. Chen. cells. H. Zhang, A. Madi, N. Yosef, N. Chihara, A. Awasthi, Beckman Res. Inst., City of Hope, Sun Yat-sen Univ., China, C. Pot, L. Apetoh, A. Srivastava, C. Wang, A. Regev and Fudan Univ., China and Tianjin Med. Univ., China. V. Kuchroo. Brigham and Women’s Hosp., Harvard Med. Sch. and MIT and Harvard.

64 SATURDAY—POSTER SESSIONS

P762 124.15 Lymph node-fibroblastic reticular cells regulate P773 125.11 Regulation of T cell activation and differentiation of CD4+ T cells through CD25. T.W. Kim and pathogenicity by dimeric pyruvate kinase M2. S. Angiari, D-E. Kim. Grad. Sch. of Med. Sci. and Engin., KAIST, South C. Sutton, M.C. Runtsch, E.M. Palsson-McDermott, Korea and Korea Inst. of Oriental Med., South Korea. K.H.G. Mills and L.A.J. O’Neill. Trinity Col. Dublin, Ireland. P774 125.12 IL-33 induces a metabolic programming 125. EPIGENETIC AND METABOLIC REGULATION supporting dendritic cells tolerogenicity. M. Velayutham, OF IMMUNITY A.S. Roessing, S. Shiva and H.R. Turnquist. Univ. of Pittsburgh Sch. of Med. Poster Session P775 125.13 Co-stimulation–induced AP-1 activity is SAT. 2:30 PM—EXHIBIT/POSTER HALL required for chromatin opening during T cell activation. A. Barski, M. Yukawa, S. Jagannathan, A.V. Kartashov, P763 125.1 Choline uptake and metabolism modulate X. Chen and M.T. Weirauch. Cincinnati Children’s Hosp. Med. macrophage immunity. E. Sanchez-Lopez, Z. Zhong, Ctr. A. Stubelius, S.R. Sweeney, L. Booshehri, L. Antonucci, P776 125.14 Macropinocytosis of amino acids regulates R. Liu-Bryan, A. Lodi, R. Terkeltaub, J.C. Lacal, T cell growth by promoting the sustained activation of A.N. Murphy, H.M. Hoffman, S. Tiziani, M. Guma and mTORC1. J. Charpentier, P.E. Lapinski, J. Turner, M. Karin. Univ. of California, San Diego Sch. of Med., Univ. I. Grigorova, J.A. Swanson and P.D. King. Univ. of S of Texas Southwestern Med. Ctr., Univ. of Texas, Austin and Michigan Med. Sch. A Hosp. Univ. Fuenlabrada, Spain. P778 125.15 A “sweet spot” for complement receptor CD46 P764 125.2 Regulation of IL-10-producing T cells by activity via direct regulation of glycolytic vs. moonlighting T polyunsaturated fatty acids. J. Hernandez Escalante, functions of GAPDH. N. Kunz, G. Le Friec, P. Singh, A. Jones, V. Volfson Sedletsky and H. Dooms. Boston P. Lavender, M. Kazemian, C. Hess and C. Kemper. Univ. Sch. of Med. NHLBI, NIH, Sch. of Immunology and Microbial Sci., King’s P765 125.3 Electrophilic nitro-fatty acids suppress Col. London, United Kingdom, Purdue Univ. and Univ. of Basel, psoriasiform dermatitis through the inhibition of STAT3 and Switzerland. NF-kB. P. Wang, M. Killeen and A.R. Mathers. Univ. of P779 125.16 Reduced glycolytic metabolism in dmLT Pittsburgh Sch. of Med. adjuvant-stimulated human antigen presenting cells P766 125.4 Chromatin interaction maps of active cis- concurrent with pro-inflammatory phenotype. A.J. Harriett, regulatory elements in primary human immune cells reveal E. Valli, K. Zwezdaryk, S. Agrawal, A. Agrawal and extensive overlap with disease-associated genetic variants. E.B. Norton. Tulane Univ. Sch. of Med. and Univ. of V. Chandra, S. Bhattacharyya, B.J. Schmiedel, A. Madrigal, California-Irvine. F. Ay and P. Vijayanand. La Jolla Inst. for Immunology. P777 125.17 XL-DNase-seq: improved footprinting of P767 125.5 A new crucial role for complement receptor dynamic transcription factors. K.S. Oh, J. Ha, S. Baek and CD46 in chromatin packaging and direct gene regulation. M-H. Sung. NIA, NIH and NCI, NIH. P. Singh, N. Kunz, G. Le Friec, M. Kazemian, B. Afzali, P801 125.18 Bach2 attenuates T cell receptor-dependent P. Lavender and C. Kemper. Lab. of Molec. Immunology and transcription to fine-tune regulatory T cell differentiation. Immunology Ctr., NHLBI, NIH, Sch. of Immunology and T. Sidwell, Y. Liao, A. Vasanthakumar, W. Shi and ’ Microbial Sci., King s College London, United Kingdom, A. Kallies. Univ. Melbourne, Australia and The Walter and Immunoregulation Section, Kidney Dis. Branch, NIDDK, NIH Eliza Hall Inst. of Med. Res., Australia. ’ and School of Immunology and Microbial Sci., King s College P802 125.19 Inhibition of cholesterol by simvastatin induces London, United Kingdom. autophagy against M. tuberculosis via the mTOR-TFEB axis. + P768 125.6 CTCF is necessary for CD8 effector T cell N. Bruiners, N. Dutta, P. Karakousis and M.I. Gennaro. differentiation. S.J. Quon, B. Yu, Z. He, B. Russ, Rutgers Univ. and Johns Hopkins Univ. S.J. Turner, C. Murre and A.W. Goldrath. Univ. of P800 125.20 DDX5 regulates chromatin lncRNAs to direct California, San Diego and Univ. of Melbourne, Australia. T cell programs. S. Ma, B. Zhou, N. Abbasi, C. Luo, G.W. Yeo, P769 125.7 Investigating the role of plasma membrane X. Fu and W.J.M. Huang. Sch. of Med., Univ. of California, San fi + order and disorder in antigen-speci c responses by CD4 T Diego and Chinese Acad. of Sci., China. lymphocytes. A.K. Bamezai, R. Karsalia and S. Sengupta. Villanova Univ. 126. CELLULAR MECHANISMS OF INNATE P770 125.8 Lipid droplets in mouse thymus express IMMUNITY II immune molecules and inhibit antigen-specific CD4+ T cell responses. A.K. Bamezai, S. Robinson and S. Humrich. Poster Session Villanova Univ. SAT. 2:30 PM—EXHIBIT/POSTER HALL P771 125.9 15(S)-HETE plays a regulatory role in the immune inflammatory responses. J. Choe and B. Kwon. P810 126.1 Epithelial versus myeloid-derived IL-33 Kangwon Natl. Univ. Col. of Med. and Kangwon Natl. Univ., controls different aspects of pathogen-specific immunity. Med. and Bio-Materials Res. Ctr., South Korea. D.R. Herbert, K. Herbine, L-Y. Hung, C. Pastore, P772 125.10 DNA methylation impairs monocyte function in B. Singh, Y. Tanaka, P.J. Bryce and T. Kambayashi. tuberculosis leading to disease progression. F.G. Frantz, Univ. of Pennsylvania, Univ. of Pennsylvania Sch. of Vet. R.C. Castro, C. Fontanari, V.R. Bollela and F.A. Zambuzi. Med. and Feinberg Sch. of Med., Northwestern Univ. Univ. of Sao Paulo, Pharmacy Sch. of Ribeirao Preto, Brazil and Univ. of Sao Paulo, Brazil.

65 SATURDAY—POSTER SESSIONS

P803 126.2 Basophil-derived tumor necrosis factor can P813 126.15 Dual function of galectin-1 in microglial enhance immune responses in a sepsis model in mice. activation of the brain. S. Jeon, H.J. Yoon and E.J. Park. A.M. Piliponsky, N.J. Shubin, A. Lahiri, P. Truong, Natl. Cancer Ctr., South Korea. M. Clauson, K. Niino, A. Tsuha, S.A. Nedospasov, P814 126.16 Activation of cannabinoid receptor type-1 and H. Karasuyama, L. Reber, M.M. Tsai, K. Mukai and type-2 inhibits the release of vascular endothelial growth factor S.J. Galli. Seattle Children’s Res. Inst., Russian Acad. of from human neutrophils. M. Braile, S. Scala, L. Modestino, Sci., Russia, Tokyo Med. and Dent. Univ., Japan and L. Cristinziano, S. Marcella, A.L. Ferraro, M.R. Galdiero and Stanford Univ. Sch. of Med. S. Loffredo. Univ. of Naples Federico II, Italy. P808 126.3 Maternal EGF limits bacterial translocation in P815 126.17 Functional significance of CD40 in the the offspring: a model of enterally acquired late onset sepsis. progression of neurotropic virus infection in the central K.A. Knoop, P. Coughlin, A. Floyd, C. Hall-Moore, M. Ndao, nervous system. D. Chakravarty, F. Saadi, S. Kundu, B. Warner, P. Tarr and R. Newberry. Washington Univ. Sch. A. Bose, R. Khan, K. Dine, L.C. Kenyon, K.S. Shindler of Med. and J. Das Sarma. Indian Inst. of Sci. Educ. and Res., P824 126.4 Unique innate functions of fetal macrophage India, Univ. of Pennsylvania and Thomas Jefferson Univ. populations. L.S. Prince, O. Lakhdari and K. Anderson. Univ. P816 126.18 Characterization of the function of murine of California, San Diego, and Rady Children’s Hosp., San guanylate-binding protein 9 in the context of bacterial and Diego. parasitic infections. J. Lichte, D. Degrandi, V. Lindenberg, P826 126.5 Microglial antigen presentation is required for K. Molleken,¨ J. Hegemann and K. Pfeffer. Heinrich-Heine antigen-specific CD8 T cell infiltration to the brain parenchyma Univ. Duesseldorf, Germany. following CNS viral challenge. E. Goddery, C. Malo, F. Jin, P817 126.19 Neutrophils are more effective than monocytes M. Hansen, J. Fryer, K. Pavelko and A. Johnson. Mayo Clin. at containment and killing of Listeria monocytogenes. Grad. Sch. of Biomed. Sci., NIAID, NIH and Mayo Clin. B. Okunnu and R.E. Berg. Univ. of North Texas Hlth. Sci. Ctr. P806 126.6 Analysis of mGBPs in host defense against the P818 126.20 Macrophage subsets determine sex obligate parasite Toxoplasma gondii. N. Steffens, L. Legewie, differences between male and female immune responses to C. Beuter-Gunia, P. Hanisch, S. Weidtkamp-Peters, Francisella tularensis. M.A. Sanchez, D. Martinez and S. Hansch,¨ D. Degrandi and K. Pfeffer. Heinrich-Heine C. Spencer. Univ. of Texas, El Paso. University, Duesseldorf, Germany. P819 126.21 Female mice express increased complement P832 126.7 Repeated malaria exposures associate with regulators and decreased intestinal ischemia-reperfusion skewing of monocytes/macrophages toward a regulatory injury. S.D. Fleming, J. Ferm and J. Amrein. Kansas State phenotype. R. Guha, G. Arora, S. Li, D. Doumtabe, Univ. O.K. Doumbo, S. Doumbo, K. Kayentao, A. Ongoiba, P820 126.22 P2X5 is required in host immunity to Listeria B. Traore and P.D. Crompton. NIAID, NIH, Univ. of Sci., infection. Y. Jeong, M.C. Walsh, J. Yu, E.J. Wherry, J. Kim Techniques and Technologies of Bamako, Mali and Mali and Y. Choi. Perelman Sch. of Med., Univ. of Pennsylvania International Ctr. of Excellence in Res., Univ. of Sci., and Univ. of Pennsylvania. Techniques and Technologies of Bamako, Bamako. P821 126.23 Dysregulation of G-CSF and neutrophil P833 126.8 Differential effects of glycerophospholipids production is associated with chronic inflammation in elderly versus glycosphingolipids on dendritic cell subsets. rhesus macaques. Z. He, N. Takahashi, M. Fahlberg, R.R. Singh and R. Halder. David Geffen Sch. of Med., N. Slisarenko, E. Didier and M. Kuroda. Univ. of Univ. of California, Los Angeles. California, Davis and Tulane Natl. Primate Res. Ctr. P804 126.9 CD40 signalling regulates mouse hepatitis P822 126.24 NLRC4 deficiency enhances macrophage and virus induced activation of microglia. F. Saadi, T cell responses in polymicrobial sepsis. S. Paudel, D. Chakravarty and J. Das Sarma. Indian Inst. of Sci. L. Ghimire, L. Jin and S. Jeyaseelan. Louisiana State Univ. Educ. and Res., Kolkata, India. P823 126.25 Anaphylatoxin receptor C3aR on platelets P805 126.10 Investigation on the role of temperature in participates in platelet function and links innate immunity macrophage responses. I.A. Hassan, J.M. Durdik, with thrombosis. R.J. Sauter, M. Sauter, E.S. Reis, R. Satyajit, Z. Renfro and H. Blake. Univ. of Arkansas and F. Emschermann, H. Nording, P. Kraft, M. Mauler, Indian Inst. of Sci. Educ. and Res., India. P. Muenzer, J. Rheinlaender, F. Edlich, T.E. Schaffer,¨ P807 126.11 Serum amyloid P component bound to fungal S.G. Meuth, D. Duerschmied, O. Borst, C. Kleinschnitz, functional amyloid Is anti-phagocytic and anti-inflammatory. J.D. Lambris and H. Langer. Univ. of Luebeck, Germany, N.E. Bradley, P.N. Lipke, D. Pilling, R.H. Gomer and Univ. of Tuebingen, Germany, Univ. of Pennsylvania, Univ. of S.A. Klotz. Univ. of Arizona, Brooklyn Col. and Texas A&M Wuerzburg, Germany, Univ. of Freiburg, Germany, Univ. of Univ. Muenster, Germany and Univ. of Essen, Germany. P809 126.12 Complement C3 increases cardiomyocyte P825 126.26 Monocytes subsets and cytokine levels in resistance to apoptosis in response to hypoxia. Z. Fang. chronic Chagas disease. J.M. Gonzalez,´ S. Gomez-Olarte,´ State Univ. of New York Downstate Med. Ctr. N. Bolaños, M. Echeverry, A. Rodr´ıguez, A. Cuellar, P811 126.13 The severities of Pseudomonas aeruginosa C.J. Puerta and A. Mariño. Univ. of los Andes, Columbia, infection are enhanced by group 2 innate lymphoid cells in Colombian Red Cross, Columbia, Javeriana Pontifical Univ., severely burned mice. I. Ito, C.C. Finnerty, D.N. Herndon, Columbia and Hosp. Universitario San Ignacio, Columbia. M. Kobayashi and F. Suzuki. Univ. of Texas Med. Br. P827 126.27 PD-1 is not expressed on highly activated P812 126.14 The functional role of CD169+ macrophages in natural killer cells in human and murine models. S.J. Judge, septic shock. S.T. Yeung and K.M. Khanna. New York Univ. C. Dunai, I. Sturgill, K. Stoffel, M. Darrow, R. Canter and Sch. of Med. W.J. Murphy. Univ. of California, Davis Med. Ctr.

66 SATURDAY—POSTER SESSIONS

P828 126.28 Baby’s first macrophage: how do placental 127. PATHOGEN CONTROL AND EVASION macrophages (Hofbauer cells) contribute to immune Poster Session tolerance and infection response during pregnancy? D. Swieboda, E. Johnson, I. Skountzou and SAT. 2:30 PM—EXHIBIT/POSTER HALL R. Chakraborty. Emory Univ., Emory Univ. Sch. of Med. P843 127.1 A novel quorum-sensing controlled type I and Mayo Clin., Rochester. effector of Pseudomonas aeruginosa, TesG, suppresses P829 126.29 Distribution and phenotypes of SLAMF9+ host immune response during chronic infection. X. Zhou, myeloid cells in mouse tissues. J.A. Mikulin and K. Zhao, J. Li and X. Zhang. Sichuan Univ., China. T.J. Wilson. Miami Univ. P844 127.2 Egr-1 deficiency protects host against P830 126.30 Sphingosine 1-phosphate is a harbinger of S. Pseudomonas aeruginosa lung infection. Z. Pang, aureus invasion and activates host defense in epithelial R. Raudonis and Z. Cheng. Dalhousie Univ. barriers. S. Igawa, J.E. Choi, Z. Wang, Y-L. Chang, P845 127.3 Leishmania major degrades CXCL1 to subvert C-C. Wu, T. Werbel, A. Ishida-Yamamoto and A. Di host immune responses. P. Gurung, M. Yorek, B. Poudel and Nardo. Univ. of California, San Diego and Dept. of L. Mazgaeen. Univ. of Iowa. Dermatology, Asahikawa Med. Univ. P846 127.4 Dysregulation of innate interferon signaling by P831 126.31 Perforin-2 dependent intracellular bacterial Epstein-Barr virus tegument protein BGLF2. S. ., K-S. Yuen, killing by skin gd T cells. K.E. O’Neill, L. Romero, V. Chaudhary, M.G. Botelho and D-Y. Jin. The Univ. of Hong S E. Fisher, D. Garcia, T. Wikramanayake, I. Pastar, Kong, China. A M. Tomic-Canic and N. Strbo. Univ. of Miami Miller Sch. of P847 127.5 Functional elucidation of miR-494 in T Med. modulation of HCV infection. T-M. Lin and H-L. Eng. I-Shou P834 126.32 Immunomodulatory capability of VCG in Univ., Taiwan and Kaohsiung Chang Gung Mem. Hosp., Chlamydia immunity. F. Eko, R. Pais, S. Richardson, Taiwan. Y.O. Omosun, C.M. Black and I. Joseph. Morehouse Sch. P848 127.6 Suppression of cGAS-STING- and RIG-I- of Med. and CDC. MAVS-mediated innate immune responses by Epstein-Barr P835 126.33 Essential roles of CCL2-CCR2 and C5a- virus-encoded tegument protein BPLF1 through de- C5aR1 pathways in irritant contact dermatitis. R. Shibuya, ubiquitination. W.Y. Lui, K-S. Yuen and D-Y. Jin. Univ. of A. Kitoh and K. Kabashima. Kyoto Univ., Japan. Hong Kong. P836 126.34 Vitamin D promotes anti-microbial activity of P849 127.7 Transient receptor potential vanilloid 4 macrophages via complement receptor immunoglobulin. regulates the host defense response to bacterial pneumonia A. Small, S. Harvey, J. Kaur, T. Putty, A. Quach, through a MAPK molecular switch. R.G. Scheraga, U. Munawara, C. Hii and A. Ferrante. Sch. of Biological S. Abraham, L. Grove, B.D. Southern, J. Crish, Sci., Univ. of Adelaide, Australia and SA Pathology, Australia. T.A. Hamilton, C. McD and M. Olman. Cleveland Clin. P837 126.35 Irgm1-deficiency leads to myeloid dysfunction P851 127.8 mGBP7 interacting proteins in Toxoplasma in colon lamina propria and susceptibility to the intestinal gondii infection and biochemical characteristics of mGBP7. pathogen Citrobacter rodentium. G. Hammer, H-I. Huang L. Legewie, J. Loschwitz, S. Smits, M. Prescher, X. Wang, and G. Taylor. Duke Univ. Sch. of Med. N. Steffens, D. Degrandi, B. Strodel, L. Schmitt and P838 126.36 Noncanonical inflammasome-induced release K. Pfeffer. Heinrich-Heine Univ. Duesseldorf, Germany. of alarmins during sepsis. A.J. Russo, A. Menoret, P852 127.9 E3 ubiquitin ligase NKLAM/RNF19b regulates S. Duduskar, G. Rabinovich, S.D. Deshmukh, A.T. Vella inflammatory cytokine production in a Sendai virus pneumonia and V. Rathinam. UConn Hlth., Jena Univ. Hosp. and model. D.W. Lawrence, L. Shornick and J. Kornbluth. Saint CEFYBO-CONICET, Argentina. Louis Univ. P839 126.37 Development of a humanized mouse model for P853 127.10 Investigations of Salmonella motility by the functional testing of biomaterial fibrosis. D.L. Greiner, defensin HD6. D.T. Akahoshi, D. Natwick, S. Collins and J.C. Doloff, A. Sadraei, S. Farah, M.A. Brehm, C.L. Bevins. Univ. of California, Davis. L.D. Shultz, R. Langer and D.G. Anderson. Univ. of P854 127.11 PTP1B negatively regulates Pseudomonas Massachusetts Med. Sch., Harvard-MIT Div. of Hlth. Sci. aeruginosa killing by neutrophil through TLR4-STAT1-iNOS and Technol. and The Jackson Lab. signaling. L. Yue, M. Yan, H. Li, T. Yang, T-J. Lin and Z. Xie. P840 126.38 Characterization of mouse peritoneal Peking Union Med. Col., China, Kunming Med. Univ., China macrophages using novel flow cytometry antibodies. and Dalhousie Univ., Canada. D. Stepniak, S. Zahner, R. Gerhart, R. Navert and P855 127.12 Expression of human TLR4/MD-2 directs an N. Schrantz. Thermo Fisher Scientific. early innate immune response associated with modest P841 126.39 Mitochondrial alterations in NK lymphocytes increase in bacterial burden during Coxiella burnetii from ME/CFS patients. I.B. Silvestre, R.Y. Dagda, infection. J.F. Hedges, A. Robison, D.T. Snyder, R.K. Dagda and V. Darley-Usmar. Sch. of Med., Univ. of A.M. Hajjar and M.A. Jutila. Montana State Univ. and Univ. Nevada and The Univ. of Alabama at Birmingham. of Washington. P842 126.40 TLR5 and TLR7 amplify different stage of P856 127.13 The host E3-ubiquitin ligase TRIM6 plays an myeloid cells. M. Jung and E.Y. Choi. Seoul Natl. Univ. important role in balancing protective innate antiviral immunity Col. of Med., South Korea. and damaging inflammation. R. Rajsbaum, L. Aguilera- Aguirre and A. Hage. Univ. of Texas Med. Br. P857 127.14 To understand the role of SteA in the The JI Editor-in-Chief Eugene Oltz will be at Booth pathogenesis of Salmonella typhimurium. A. Gulati, 1101 today, Saturday, May 11, from 2:30 PM – 3:45 PM. R. Shukla and A. Mukhopadhaya. Indian Inst. of Sci. Educ. and Res., Mohali, India.

67 SATURDAY—POSTER SESSIONS

P860 127.15 Rapidly evolving PARP proteins act as both P875 128.4 ICOS signaling in visceral adipose tissue positive and negative regulators of the antiviral response. regulatory T cell homeostasis and function. A. Ryan, J. Schwerk, F. Soveg, R. Savan and K.L. Mittelsteadt and D.J. Campbell. Univ. of Washington M. Daugherty. Univ. of California, San Diego and Univ. of and Benaroya Res. Inst. Washington. P877 128.5 Role of Ets transcription factors in the P861 127.16 Early host responses to cattle gastro-intestinal development of TH9 cells. R.P. Kharwadkar, B.J. Ulrich, parasite Ostertagia ostertagi. M. Bakshi, W. Tuo and Y. Fu and M.H. Kaplan. Indiana Univ. Sch. of Med. D. Zarlenga. USDA-ARS Animal Parasitic Dis. Lab. P876 128.6 Prolonged activation in CD4+ T cells results in P862 127.17 Innate immune role for the macrophage extensive mitochondrial remodeling despite the metabolic galactose lectin pathway in pulmonary tuberculosis. dominance of aerobic glycolysis. B. Akkaya, A. Roesler, K.F. Naqvi, T.B. Saito, M.B. Huante, B.B. Gelman and B.P. Theall, J.A. Al Souz, P. Miozzo, J. Traba, J.J. Endsley. Univ. of Texas Med. Br. M. Smelkinson, J. Kabat, D. Dorward, S.K. Pierce and P863 127.18 STAT2 is a determinant of yellow fever virus M. Akkaya. NIAID, NIH and NHLBI, NIH. host tropism. J. Morrison, L. Miorin, M. Laurent-Rolle, P879 128.7 Egr2 deficiency significantly impairs the G. Pisanelli, P. Co, R. Albrecht and A. Garc´ıa-Sastre. development of pathogenic TH17 cells. Y. Gao, Y. Wang, Univ. of California, Riverside, Icahn Sch. of Med. at Mount Y. Guan, N.J. Bouladoux, T. Break, M.S. Lionakis, Sinai, Yale Univ. Sch. of Med. and Queens Col., City Univ. of Y. Belkaid and V. Lazarevic. NCI, NIH and NIAID, NIH. New York. P1200 128.8 The Ikaros zinc finger transcription factor Eos + + P864 127.19 Activation of AMPK restricts Zika virus regulates CD4 TH1 and CD8 TC1 differentiation programs. replication in endothelial cells by potentiating antiviral B.K.N. Sreekumar, M.D. Powell, K. Read, J. Zafar, D. Jones, response and inhibiting viral-induced glycolysis. A. Kumar, C. Baker, I.C. Allen and K.J. Oestreich. Carilion Sch. of Med., S. Singh, P. Singh and S. Giri. Wayne State Univ. Sch. of Virginia Polytechnic Inst. and State Univ. and Virginia- Med. and Henry Ford Hlth. Sys. Maryland Col. of Vet. Med. P865 127.20 Suppression of human STAT2 by ZIKV NS5. P874 128.9 Discovery and functional analysis of novel R. Hai, B. Wang, S. Thurmond and J. Song. Univ. of regulatory T cell marker, TregS. J. Yoon, D.D-H. Lee and California, Riverside. S-W. Lee. Yonsei Univ., South Korea, Univ. of California, Los P858 127.21 Dual oxidase1 ameliorates survival, viral Angeles and Yonsei Univ. Col. of Med., South Korea. clearance, and pulmonary pathology during influenza P878 128.10 TCF1 and LEF1 control Treg competitive infection. D. Sarr, A. Gingerich, M. Colon, T. Nagy, survival to maintain immune tolerance. W. Fu and R.A. Tripp and B. Rada. Univ. of Georgia. B-H. Yang. Univ. of California, San Diego. P859 127.22 Neutrophil maturation and their response to P872 128.11 The role of Blimp-1 in adipose Treg infectious pathogens are regulated by microbiota. differentiation and effector function. L. Beppu, A. Frias, M. Gadjeva, A. Kugadas, A. Petenkova, J. Geddes- E. Hyzny, A. Poholek and L. D’Cruz. Univ. of Pittsburgh McAlister, M.K. Mansour and D. Sykes. Brigham and Sch. of Med. Women’s Hosp., Harvard Med. Sch., Max Planck Inst. of P870 128.12 Gata3 plays a supportive role for the Biochemistry, Germany and Massachusetts Gen. Hosp. development of Tbet-expressing Th17 cells in EAE. P850 127.23 Listeria hijacks host cell mitophagy to evade M.J. Butcher, R.K.H. Gurram and J. Zhu. NIAID, NIH. killing through a novel mitophagy receptor. Y. Qian. Shanghai P867 128.13 RAS P21 protein activator 3 specifically Institutes for Biol. Sci., China. promotes pathogenic T helper 17 cell generation by P866 127.24 Inhibitory effect of short-chain fatty acids on the repressing T helper 2-biased programs. B. Wu. Univ. of induction of nitric oxide by Staphylococcus aureus lipoproteins North Carolina, Chapel Hill. in macrophages. S.H. Han, J.W. Park, H.Y. Kim, M.G. Kim, P873 128.14 BATF-interacting proteins dictate specificity in S. Jeong and C-H. Yun. Seoul Natl. Univ., South Korea. Th subset activity. Y. Fu, B. Koh, B.J. Ulrich, R. Kharwadkar and M.H. Kaplan. Indiana Univ. Sch. of Med. 128. CD4+ T CELL DIFFERENTIATION P1201 128.15 Placenta-specific 8 negatively regulates IFNg AND FUNCTION production by Th1 cells. C.D. Slade, K.L. Reagin, K.D. Klonowski and W.T. Watford. Univ. of Georgia. Poster Session P1202 128.16 Akt phosphorylation of hnRNP A1 controls SAT. 2:30 PM—EXHIBIT/POSTER HALL CD4+ T cell fate decisions. Y. Jin, T.L. White, M. Gable and P. Morel. Univ. of Pittsburgh. P868 128.1 Novel Foxp3 regulators discovered by a P1203 128.17 2A-DUB/Mysm1 in lymphoid development and genome-wide CRISPR screen. C.S. Loo and Y. Zheng. Treg function. M.V. Gatzka, I. Krikki and H.V. Hainzl. Uni Ulm, Salk Inst. for Biological Studies. Germany. P869 128.2 CIS inhibits Treg-intrinsic TH2 program and P1204 128.18 Substrate rigidity affects human regulatory fl suppresses allergic airway in ammation. X.O. Yang, T cell induction in vitro. L. Shi, J.H. Lee and L. Kam. H. Zheng, X. Wu, R-L. Jiang, E. Castillo, C. Chock, Columbia Univ. Q. Zhou, M. Liu and C. Dong. Univ. of New Mexico Sch. of P1205 128.19 Profile of double positive T cells (CD45+CD3+ Med. and Tsinghua Univ., China. CD4+CD8+) in HIV-infected population in Santos City, Brazil. P871 128.3 Id2 is necessary for differentiation and survival S.A.d. Silva, C.R.d. Almeida and C.R.d.S. Barros. Catholic of adipose-resident Tregs. A.B. Frias, E.J. Hyzny, Univ. of Santos, Brazil. L.Y. Beppu, H.M. Buechel and L.M. D’Cruz. Univ. of Pittsburgh Sch. of Med.

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P1206 128.20 In vivo induction of T regulatory cells with P1219 129.11 Noncanonical NF-kB controls stem cell recombinant mouse IL-2_anti-mouse IL-2 antibody complex. signatures in the colonic mucosa and affects susceptibility to H. Soto, J. Moyron-Quiroz, Z.R. Moya, M. Tam, J.M. Love, inflammation-induced carcinogenesis. I.C. Allen, K. Eden, X. Yang, D. Nguyen and J. Zhou. BioLegend and BioLegend, H. Morrison, D. Rothschild, S. Brown and E. Holl. Inc. Virginia Tech, Virginia Polytechnic Inst. and State Univ., Edward Via Col. of Osteo. Med. and Duke Univ. Sch. of Med. 129. IMMUNE DEVELOPMENT AT MUCOSAL SITES P1220 129.12 Intrinsic factor recognition promotes Th17/Th1 autoimmune gastric inflammation in patients with pernicious Poster Session anemia. A. Troilo, A. Grassi and M.M. D’Elios. Univ. Med. SAT. 2:30 PM—EXHIBIT/POSTER HALL Ctr. Freiburg, Germany and Univ. of Florence, Italy. P1221 129.13 A cognate interaction between T cell- fi P1207 129.1 Adventitial stromal cells de ne group 2 innate expressed BTLA and B cell-expressed HVEM regulates lymphoid cell tissue niches. A.B. Molofsky, M.W. Dahlgren, mucosal immunity in the gut. C. Stienne, A. Moshayedi, S.W. Jones, A. Dubinin, S. Farhat, J.F. Ortiz-Carpena, E. Chappell, C.F. Ware and J.R. Sedy. Sanford Burnham K.S. Yu, K. Lee, C. Wang, A.V.R. Molofsky, A.D. Tward, Prebys Med. Discovery Inst. M.F. Krummel and T. Peng. Univ. of California, San P1222 129.14 Differentiation and dynamics of circulating and Francisco. tissue-resident memory CD8 T cells in the lung. S.M. Anthony S P1208 129.2 Persistent antigen can maintain lung resident and J.T. Harty. Carver Col. of Med., Univ. of Iowa. A memory CD8 T cells long-term. I.E.M. Uddback, P1223 129.15 D-amino acid oxidase contributes IgA E. Cartwright, A. Skak Schøller, S.L. Hayward, J. Lobby, nephropathy through regulation of IgA production in T S. Takamura, A.R. Thomsen, J.E. Kohlmeier and intestinal mucosa. M. Suzuki, T. Sujino, M. Goto, J.P. Christsensen. Univ. of Copenhagen, Denmark, Emory R. Takahashi, M. Ito, J. Sasabe and M. Yasui. Keio Univ. Univ. Sch. of Med. and Kindai Univ., Japan. Sch. of Med. and Central Inst. for Exptl. Animals. fi P1209 129.3 Aire de ciency during early pregnancy leads to P1212 129.16 Memory B cell recruitment to the vaginal maternal T cell imbalance and embryo loss. E.M. Gillis-Buck, mucosa is required for luminal antibody secretion. J.E. Oh, J.M. Gardner, J.L. Bautista, M.S. Anderson, A. Erlebacher N. Iijima and A. Iwasaki. Yale Univ. Sch. of Med. and T.C. MacKenzie. Univ. of California, San Francisco. P1217 129.17 Intestinal goblet cells and goblet cell- fi P1210 129.4 Dissecting the tissue-speci c mechanisms that associated antigen passages regulate the balance between support the maintenance of intestinal regulatory T cells. Tregs and Th17. D.H. Kulkarni, J. Gustafsson, J. Davis, E. Cruz Morales, A.P. Hart and T.M. Laufer. Univ. of K. McDonald, C. Hsieh and R.D. Newberry. Washington Pennsylvania. Univ., St. Louis. P1211 129.5 The skin: a site of extralymphoid IgM P1224 129.18 Single-cell RNA-seq of young and aged production. S.E. McGettigan, R.P. Wilson, V.D. Dang, alveolar macrophages. Y. Wu, B. Zhu, N.G. Goplen, A. Kumar, N. Nikbakht, W. Stohl and G.F. Debes. R. Zhang, Y. Li, A.N. Cardani, T.J. Braciale and J. Sun. Thomas Jefferson Univ., Univ. of Pennsylvania and Univ. of Mayo Clin. Col. of Med. and Sci. and Carter Immunology Ctr., Southern California. Univ. of Virginia. P1213 129.6 Absence of conventional dendritic cells type 1 impairs intestinal homeostasis and permeability and leads to 130. TECHNOLOGICAL INNOVATIONS I the development of obesity. H. Hamade, J.T. Stamps, L.S. Thomas, D. Stamps, Y. Shimodaira and Poster Session K.S. Michelsen. Cedars-Sinai Med. Ctr., Los Angeles. SAT. 2:30 PM—EXHIBIT/POSTER HALL P1214 129.7 Small intestinal cytotoxic CD4 T cells: novel mechanisms of development and unique protective capability. P1233 130.1 Pressure enabled drug delivery of anti-CEA A. Chen, H. Iwaya, N. Thiault and H. Cheroutre. La Jolla Inst. CAR-T cells increases intra-hepatic CAR-T tumor for Allergy and Immunology. penetration and therapeutic index in a murine model of liver P1215 129.8 Tissue driven influences on human NK cell metastasis. J.C. Hardaway, L.F. Chai, M. Lopes, development, function and residence. P. Dogra, C. Rancan, B. Rabinowitz, P. Guha, D. Jaroch, B. Cox, R. Knight, W. Ma, M. Toth, T. Senda, D.J. Carpenter, P. Thapa, J. Zeldis, N.J. Espat and S.C. Katz. Roger Williams Med. P.A. Szabo, Y. Shen, L. Fong, L.L. Lanier and Ctr., TriSalus Life Sci., Inc. and Sorrento Therapeutics, Inc. D.L. Farber. Columbia Univ. Med. Ctr., Univ. of California, P1238 130.2 Use of modified peptides for live tracking of San Francisco and Univ. of Debrecen, Hungary. peptide-MHCII complexes during antigen-specific T cell- P1216 129.9 Indiscriminate nature of lung resident CD8+ dendritic cell interactions. J.A. Al Souz, M. Akkaya, TRM cells reactivation and their varied reactivation profiles. R. Kamdar, O. Kamenyeva, J. Kabat, E.M. Shevach and J.S. Low, C. Amezcua, E. Sefik, C.C.D. Harman, B. Akkaya. LISB, NIAID, NIH, LIG, NIAID, NIH, Univ. of R. Jackson, X. Jiang, J.B. Kelly, L.S. Cauley, R.A. Flavell Maryland, Baltimore County and RTB, NIAID, NIH. and S. Kaech. Yale Univ. Sch. of Med., Stony Brook Univ., P1242 130.3 Comprehensive benchmarking of T-cell Univ. of Connecticut and The Salk Inst. epitope prediction tools. S. Paul and B. Peters. La Jolla P1218 129.10 Development of conventional, but not tissue- Inst. for Allergy and Immunology. resident, NK cells requires pH-controlling vacuolar a2v- ATPase. K.D. Beaman, S. Schnederman, G. Katara and S. Dambaeva. Chicago Med. Sch., Rosalind Franklin Univ. of Med. and Sci.

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P1247 130.4 High throughput pMHC-I multimer library P1236 130.18 Isolation of mouse CD45 positive leukocytes production using chaperone-mediated peptide exchange. from tissues. F. Antignano, G. Poon, V. Facca, L. Separovic, S. Overall, J.S. Toor, M. Yarmarkovich, S. Hao, Y. Valdez, A.I. Kokaji, S.M. Woodside, A.C. Eaves and S. Nguyen, A. Sada-Japp, M.R. Betts, J.M. Maris, T.E. Thomas. STEMCELL Technol. P. Smibert and N.G. Sgourakis. Univ. of California, Santa P1237 130.19 Use of recombinant influenza vaccines Cruz, Children’s Hosp. of Philadelphia, New York Genome Ctr. expressing exogenous miRNAs for increased vaccine and Inst. for Immunology, Perelman Sch. of Med., Univ. of production. J. Stambas, S. Ye, A. Bakre, S. Edwards, Pennsylvania. D. Dlugolenski and R.A. Tripp. Deakin Univ. and Univ. of P1254 130.5 Development of sialoglycan recognizing Georgia. probes with defined specificities: towards exploring the P1239 130.20 Identifying antibodies and T-cell receptors with dynamic mammalian sialoglycome. S. Srivastava, known specificity in repertoire sequencing data. S. Mahajan, A. Verhagen, B. Wasik, H. Yu, A. Sasmal, B. Bensing, R. Vita, Z. Yan, M. Nielsen, A. Sette and B. Peters. La Jolla N. Khan, Z. Khedri, S. Diaz, P. Sullam, N. Varki, X. Chen, Inst. for Allergy and Immunology and Tech. Univ. of Denmark, C. Parrish and A. Varki. Sch. of Med., Univ. of California, San Kgs. Lyngby, Denmark. Diego, Col. of Vet. Med., Cornell Univ., Univ. of California, P1240 130.21 MHC clustering regulates selectivity and Davis and Sch. of Med., Univ. of California, San Francisco. effectiveness of T-cell responses. N. Anikeeva, P1255 130.6 Genome-wide CRISPR wcreens in primary N.O. Fischer, C.D. Blanchette and Y. Sykulev. Thomas human T cells reveal key regulators of immune function. Jefferson Univ. and Lawrence Livermore Natl. Lab. E. Shifrut, J. Carnevale, A. Ashworth and A. Marson. P1241 130.22 Combining TruCulture and OptiMAP to profile Univ. of California, San Francisco. human immune immunity. S-A. Hwang, D. Eisinger and P1250 130.7 Imaging cancer immunology: tracking immune S. LaBrie. Myriad RBM. cells in vivo with magnetic particle imaging. J. Gaudet, P1243 130.23 Highly multiplexed single-cell spatial analysis J. Mansfield and P. Goodwill. Magnetic Insight. of tissue specimens using CODEX. S. Mistry, P1225 130.8 Novel plate-based detection method for T cell G. Dakshinamoorthy, J. Singh, N. Nikulina, J. Kim, activation/proliferation, migration, and cytotoxicity assay using R. Bashier, M.E. Gallina and J. Kennedy-Darling. Akoya image cytometry. L. Chan. Nexcelom Biosci. Biosciences Inc. P1226 130.9 WITHDRAWN P1244 130.24 Quantifying immune effector molecules from P1227 130.10 Mouse models for iImmunology research mouse leukocytes with flow-based multiplex assay panels. available from The Jackson Laboratory Repository. B. Sun, P. Rughwani, K. Chow, A. Zhao, J. Lehmann, A. Valenzuela, K. Fancher, S. Rockwood and C. Lutz. W. Jiang and S. Ji. BioLegend, Inc. Jackson Lab. P1245 130.25 Novel flow-based multiplex assay panel for P1228 130.11 Novel therapeutic strategies to mitigate erectile quantifying human neuroinflammation biomarkers. B. Sun, dysfunction in a rat pelvic trauma model. A.M. Hertz, K. Chow, A. Zhao, J. Lehmann, W. Jiang and S. Ji. E. George, J. Hibbert, A. Reed-Maldonado, T. Brand and BioLegend, Inc. S. Salgar. Madigan Army Med. Ctr. P1246 130.26 Formal representation of immunology related P1229 130.12 Generation of a novel GATA3 reporter and data with ontologies. R.J. Vita, J.A. Overton, K-H. Cheung, inducible deletion system to study GATA3hi Th2 and ILC2 P. Dunn, J. Burel, S.A. Chan, A.D. Diehl, S.H. Kleinstein, cells in vivo. R.K. Gurram, C. Liu and J. Zhu. NIAID, NIH A. Sette and B. Peters. La Jolla Inst. for Allergy and and NHLBI, NIH. Immunology, Knocean, Inc., Canada, Yale Univ. Sch. of P1230 130.13 DNA origami probes for single-cell paired BCR Med., NG Health Solutions and Univ. at Buffalo, State Univ. heavy and light chain immune repertoire analysis. of New York. N. Chaudhary, L. Schoettle, C. Dubois, K. Jones, P1248 130.27 REAlease® technology: controlled release of P.R. Ulrich, H. Yan and J.N. Blattman. The Biodesign Inst. antibody-fluorochrome conjugates for maximal flexibility in and Sch. of Life Sci., Arizona State Univ. flow sorting applications. C.Evaristo,J.Pankratz, P1231 130.14 A fast and robust protocol for immunomagnetic S. Schmachtenberg, N. Jansen, S. Krauthauser,¨ isolation of human CD45+ leukocytes from samples with A. Kinkhabwala, K. Schlegel, C. Siewert, A. Bartholomaus,¨ variable start frequencies. V. Posarac, C.L. Ewen, S. Meiler, D.A. Yushchenko and C. Dose. Miltenyi Biotec, V.K. Jovanovic, E. Hayer, A.I. Kokaji, S.M. Woodside, Germany. A.C. Eaves and T.E. Thomas. STEMCELL Technol., Canada. P1249 130.28 A robust and scalable method to crosslink P1232 130.15 Using immune cell type-specific gene antibodies and proteins. Q. Zhao, D. Patel, H. Wu, J. Liao backgrounds for refined GO enrichment analysis: an and Z. Diwu. AAT Bioquest Inc. example from CD4 T cell transcriptomics of TB-infected P1251 130.29 20,000 layers under the model: Bayesian individuals. M. Pomaznoy, B. Ha and B. Peters. La Jolla neural networks improve the robustness of human PBMC Inst. for Immunology. classifications using immunologist-encoded bias. P1234 130.16 Multiparametric analysis of cell health status M.A. Velazquez-palafox, I.J. Taylor, J. Spidlen, J. Lai, using flow cytometry. Q. Low, V. Calderon, L. Montoya and R. Halpert and M. Stadnisky. Flowjo and BD Biosciences. M. O’Grady. Thermo Fisher Scientific. P1252 130.30 Real-time visualization and quantification of P1235 130.17 Detection of small particles by flow cytometry: neutrophil activation and function using live-cell analysis. analysis of small particle beads and extracellular vesicles. N. Bevan, G. Lovell, B. O’Clair, L. Kelsey, C. Szybut, L.A. Jachimowicz, P. Ye, Y. Lu, G. Guenther and N. Li. H. Campwala, T. Jackson, N. Holtz, E. Endsley, T. Dale ACEA BioSci. and D. Trezise. Essen Bioscience, United Kingdom.

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P1253 130.31 New generation CD90.1 and CD90.2 P1267 131.3 Integration of multi-omics data from re-wilded MicroBeads: fast isolation of total of adoptively transferred laboratory mice to identify key parameters that determine T cells from mouse spleen. C. Evaristo, C. Pitzka, N. Pietz, immune heterogeneity and activation. J-D. Lin, F. Yeung, A. Foerster-Marniok, C. Dose and A. Richter. Miltenyi C. Devlin, Y-H. Chen, C. Mccauley, A. Cronkite, Biotec, Germany. J.M. Leung, A.L. Graham, K.H. Cadwell and P. Loke. P1256 130.32 Rapid modification of specificity and affinity of NYU Med. Ctr., Univ. of Central Florida Col. of Med. and anti-influenza VHH antibody using two in vitro evolution Princeton Univ. methods. H. Kishimoto, M. Yoshida, N. Tsukahara, P1268 131.4 Scalable and comprehensive characterization T. Matsubara, H. Nakayama and A. Murakami. Univ. of of antigen-specific CD8 T cells using multi-omics single cell the Ryukyus, Japan, RePHARGEN and Panasonic Co. Ltd. analysis. S.C. Boutet, D. Walter, M.J.T. Stubbington, P1257 130.33 Development of PureQuant real-time PCR- K.A. Pfeiffer, J.Y. Lee, S.E.B. Taylor, L. Montesclaros, based assay for assessment of immune cell identity and J.K. Lau, D.P. Riordan, A.M. Barrio, L. Brix, K. Jacobsen, purity in CAR-T workflows. S. pradhan, J. Guzman, B. Yeung, X. Zhao and T.S. Mikkelsen. 10x Genomics, M. Landon, C. Dargitz and U. Lakshmipathy. Thermo Immudex, Denmark and BioLegend, Inc. Fisher Scientific. P1269 131.5 Immunophenotyping extracellular vesicles P1260 130.34 The utility of benzathine penicillin G for using the CellStream flow cytometer. H.R. Pugsley, rheumatic fever prevention in the Solomon Islands. D. Sika- B.R. Davidson and P. Morrissey. Luminex Corp. S Paotonu and U. Liligeto. Wellington Sch. of Med. & Hlth. Sci., P1305 131.6 A novel method for high throughput TCR single A Univ. of Otago, New Zealand and Victoria Univ. of Wellington, cell VDJ-pairing with phenotypic analysis. M. Byrne-Steele, T New Zealand. W. Pan, B.E. Brown, X. Hou, M. Depinet, M. Eisenhower, P1261 130.35 Identifying predictive cytokine biomarkers in D. Weber and J. Han. iRepertoire. asthma and chronic obstructive pulmonary disease using P1314 131.7 Developing a novel multiplexed high the Invitrogen ProQuantum high-sensitivity immunoassay throughput flow cytometry based immune assay to screen platform. D.M. Bourdon, H. Ekoff, A. Sjolander,¨ kinase modulators of primary T cell activation. J. O`Rourke, T. Fujisawa, M. Nagao and M. Molin. Thermo Fisher A. Gomez-Donart, C. Weldon and Z. Liu. Essen Biosciences. Scientific and Mie Natl. Hosp., Japan. P1310 131.8 Development of high-throughput methods P1262 130.36 Development and application of an in vitro used to identify and characterize novel interactions within dendritic cell internalization assay to assess immunogenicity the human secretome with focus on the Ig and TNF risk. M. Halimani, K. Atkuri, P. Goiberg, Z. You, G. Steeno, receptor superfamilies. S.C. Garrett-Thomson and S. Tourdot, L. Xue, C. Lepsy, T. Hickling and L. King.Pfizer, S. Almo. Albert Einstein Col. of Med. Inc. P1270 131.9 Immunomagnetic cell separation is a suitable P1263 130.37 Early cancer detection in the Pacific. D. Sika- method for T cell electrophysiology and ion channel Paotonu, U. Liligeto and P. Guilford. Wellington Sch. of Med. pharmacology. G. Tajti, T.G. Szanto, G. Racz, A. Csoti, & Hlth. Sci., Univ. of Otago, New Zealand, Victoria Univ. of P. Hajdu and G. Panyi. Fac. of Med., Univ. of Debrecen, Wellington, New Zealand and Univ. of Otago, New Zealand. Hungary. P1264 130.38 Cancer in Pacific Populations in New Zealand P1271 131.10 The “crisis of reproducibility” of animal studies: and ctDNA technology for early cancer detection. D. Sika- causes and solutions. L.M. Shollenberger, H. Hentze and Paotonu and P. Guilford. Wellington Sch. of Med. & Hlth. Sci., E. Ibsen. Old Dominion Univ., Vivology Consulting, Singapore Univ. of Otago, New Zealand and Univ. of Otago, New and Studylog Sys., Inc. Zealand. P1272 131.11 A universal planar assay format for high P1258 130.39 Zika virus detection using a flow cytometry sensitivity cytokine quantification in human serum and platform. S.C. Wood. Ctr. for Devices and Radiological plasma. J. Lambert, M. Mendes, Y-X. Yan and A. Ball. Hlth., FDA. Quanterix. P1259 130.40 Generation of a B-1 lymphocyte-specific P1273 131.12 Adarza’s Ziva technology platform enables conditional knockout mouse model Bhlhe41tdTomato-Cre. highly multiplexed label-free detection of serum analytes. H. Wang, L. Hong, Y. Tang, M. Xu, S. Pan, Q. Wang and J.J. Schmuke, E. Mueller, A. Darby, T. Wente-Roth, C. He. Xuzhou Med. Univ., China. N. Vohra, J. Haley, T. Hodge and M. Pillers. Adarza. P1274 131.13 An advancement in single-cell genomics 131. TECHNOLOGICAL INNOVATIONS II allows for T cell population analysis at high resolution. D.J. Sukovich, S.E.B. Taylor, K.A. Pfeiffer, Poster Session M.J.T. Stubbington, J.Y. Lee, J. Sapida, D.P. Roidan, SAT. 2:30 PM—EXHIBIT/POSTER HALL A.M. Barrio, D. Walter, L. Brix, K. Jacobsen, B. Yeung, X. Zhao and T.S. Mikkelsen. 10x Genomics, Immudex and P1265 131.1 Buoyant microbubbles as alternatives or BioLegend, Inc. adjuncts to magnetic bead methods for high-purity cell P1275 131.14 Controlled temp for cell plating eliminates room isolation. J.G. Younger, J. Roussey, J. Bao, N. Petlakh temp cell settling in 96-well plates, reducing edge effect and Co, T. Jones and L. Ostruszka. Akadeum Life Sci. improving cell conditions. A.D. Henn, S. Darou, S.P.D. Henn, fl P1266 131.2 A robust human immunophenotyping work ow A.M. Frank, K. Alm and R. Yerden. BioSpherix and Phase using CyTOF technology coupled with Maxpar Pathsetter, an Holographic Imaging, Sweden. automated data analysis software. S.K.H. Li, D. Majonis, P1276 131.15 Optimum processing conditions for single-cell C.B. Bagwell, B.C. Hunsberger, V. Baranov and RNA sequencing on frozen human PBMCs. R. Hanamsagar, O. Ornatsky. Fluidigm, Canada and Verity Software House. R. Marcus, M. Chamberlain, E. de Rinaldis and V. Savova. Sanofi.

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P1277 131.16 WITHDRAWN P1312 131.29 Microchip platform for imaging-based efficacy P1278 131.17 The contribution of tumor type, stage, and testing of cells and reagents for immunotherapy. B. Onfelt, antigen in the antibody-antigen kinetics by ELISA in adult K. Guldevall, L. Brandt, K. Olofsson, V. Carannante, and pediatric cancer patients. J.P. Marquez-Manriquez, N. Sandstrom¨ and M. Wiklund. KTH-Royal Inst. of J.A. Matute-Briseno, A. Camacho-Hernandez, S. Icedo- Technol., Sweden and Karolinska Inst., Sweden. Zamora and P.A. Lucero-Diaz. CICS USA. P1313 131.30 Transcriptomic analysis of paired nasal and P1279 131.18 Database of immune cell EQTLs, expression, bronchial brushes in cystic fibrosis patients. C.J. Erb and epigenomics. B. Ha, J.A. Greenbaum, B.J. Shmiedel, K. Chen. Univ. of Pittsburgh. D. Singh, A. Madrigal, A.G. Valdovino-Gonzalez, P1315 131.31 Human G-CSF knockin NOG mice support the B.M. White, J. Zapardiel-Gonzalo, G. Altay, G. McVicker, differentiation of human neutrophils and recapitulate an G. Seumois, A. Rao, M. Kronenberg, P. Vijayanand and emergency granulopoiesis after bacterial infection. R. Ito, B. Peters. La Jolla Inst. for Immunology and Salk Inst. for I. Katano, T. Takahashi, M. Goto, R. Takahashi and Biological Studies. M. Ito. Central Inst. for Exptl. Animals. P1300 131.19 Optimizing the pharmacokinetic properties of P1316 131.32 A pathogen-free flow cytometry based polymeric IgA in mice. S. Rajan, N.T. Lombaba, opsonophagocytosis assay protocol to quantify antibody- D. Mandikian, A. Boswell, V. Yip, D. Bravo-Perez, mediated phagocytosis. A.J. Badten, J. Felgner, E. Chen, J. Wang, W. Phung, S. Lee, F. Farahi, E.J. Pone, T.J. Albin, C. Fellon, K. Kang, P.L. Felgner A. Estevez, A. Gill, W. Sandoval, S. Viajar, C. Ciferri, and A.M. Burkhardt. Univ. of California, Irvine. M. Matsumoto and C. Spiess. Genentech, Inc. P1317 131.33 MagDye for flow cytometry. A.Y. Wang, X. Ji, P1301 131.20 The immune epitope database enables and Y. Zhang and W. Smith. Ocean NanoTech LLC and Thermo accelerates research. N. Salimi, R. Vita, S. Mahajan, Fisher Scientific. J.A. Overton, S.K. Dhanda, S. Martini, J.R. Cantrell, P1318 131.34 Cis-proteomics reveals novel transcriptional D.K. Wheeler, A. Sette and B. Peters. La Jolla Inst. for regulators of Treg development and function. Y. Feng and Allergy and Immunology, Knocean, Inc. and Leidos Hlth, LLC. X. Zong. St. Jude Children’s Res. Hosp. P1302 131.21 Intracellular pairing of multiple mRNA species P1319 131.35 Single cell whole transcriptome analysis of at the single-cell level using DNA origami. P.R. Ulrich, disease cells to generate a targeted RNA-sequencing gene L. Schoettle, C. Dubois, K. Jones, N. Chaudhary, panel for the simultaneous analysis of targeted mRNA and K.S. Anderson and J. Blattman. Arizona State Univ. and protein. N. Bansal, H-W. Song, S. Sa, W.E. Lomas, The Biodesign Inst. G.V. Baracho, I. Taylor, S. Widmann and S. Mortimer.BD P1303 131.22 Evidence of improved transduction and Biosciences and FlowJo, LLC. preservation of relevant T cell subpopulations using different P1320 131.36 Antibody epitope mapping at single residue media conditions: towards a novel CAR-T media formulation. resolution for unpurified antigens. J. Pan and S. Zhang. F.J. Martinez Becerra, R. O’Connor, S. Ghassemi, D. Heo NovoAb Bioanalytics Inc. and A. Master. Nucleus Biologics and Perelman Sch. of Med., P1321 131.37 Mapping leucocyte populations in mouse Univ. of Pennsylvania. lymphoid tissues and blood using a 28-color panel on the P1304 131.23 Gene conversion identification and analysis in BD FACSymphonyTM system. G. Baracho, S. Widmann, immunoglobulins. S.R. Bonissone. Digital Proteomics. C. Sisouvanthong, A. Tyznik and S. Saksena.BD P1306 131.24 T cell receptor repertoire detection from dry Biosciences. blood spots. S. Li, W. Pan, S-G. Wu, H. Liu, M. Byrne-Steele, P1322 131.38 Comparative analysis of immunoglobulin IGHD B.E. Brown, M. Depinet, X. Hou and J. Han. iRepertoire, Natl. genes in vertebrates. V. Bhardwaj, Y. Safonova, Taiwan Univ. Hosp., Taiwan and iCubate. M. Franceschetti, R. Rao and P. Pevzner. Univ. of P1307 131.25 Physical cognate pairing of mouseTCR alpha- California, San Diego. beta VDJ-rearrangements with phenotype directly from FACS P1323 131.39 Lipid composition impacts the assembly of sorted cells. B.E. Brown, M. Byrne-Steele, W. Pan, X. Hou, MHC class II molecules in nanodiscs. T.A. Becker, M. Depinet, M. Eisenhower and J. Han. iRepertoire. J. Osan, K. Rivera, J. Polanco, A. Ferrante and T. Kuhn. P1308 131.26 Investigating the human immune response Univ. of Alaska, Fairbanks. with Myriad RBM’s TruCulture system and the NanoString P1324 131.40 Simultaneous mRNA, protein, and immune- nCounter Autoimmune Profiling Panel. N.A. Elliott, repertoire profiling of thousands of single cells. C. Chang, S-A. Hwang, M. Bailey, C. Bailey, S. LaBrie and M. Nakamoto, J. Lai, I. Siddique and S. Mortimer.BD S. Warren. NanoString Technologies and Myriad RBM. Biosciences. P1309 131.27 Improving expression estimates of HLA alleles P1325 131.41 Evaluation of cytometer sensitivity and stability in NGS data using personalized genomic sequences and its using automated analysis. J.A. Bradford, J. Meskas and effect on eQTL mapping. A. Crinklaw, S. Mahajan, P. Sardina. Thermo Fisher Scientific and Cytapex M. Pomaznoy, A. Sette, P. Vijayanand and B. Peters.La Bioinformatics, Inc., Canada. Jolla Inst. for Immunology. P1311 131.28 Complete all-in-one immune repertoire REMINDER profiling of newborn babies via novel dimer-avoided multiplex PCR (dam-PCR). X. Hou, W. Pan, M. Depinet, B.E. Brown, M. Eisenhower, M. Byrne-Steele, M. Weber, M. Dworsky, S. Callison and J. Han. iRepertoire, Tennessee Valley Neonatalogy and Tennessee Valley OB GYN.

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132. TREATMENT STRATEGIES IN LUPUS P1336 132.13 Sinomenine attenuates Ang II induced autophagy via inhibition of P47-phox translocation in Poster Session podocytes, and also attenuates Ang II by podocytes induced SAT. 2:30 PM—EXHIBIT/POSTER HALL under NETs. W. Wang and J. Zhang. Army Medical Univ., Xinqiao Hosp., China. P1327 132.1 Innovative drug discovery for autoimmune P1338 132.14 Characterization and optimization of SLE diseases aiming at BAFF signaling pathway. K. Yoshimoto, mouse models for the evaluation of immunomodulation K. Suzuki, N. Seki, K. Sugahara, K. Chiba and T. Takeuchi. therapeutics. L. Case, H. Knowlton, G. Christianson, Keio Univ. Sch. of Med., Japan and Mitsubishi Tanabe Pharma L. Vann and C. Lutz. Jackson Lab. Corp. P1339 132.15 Improved antimalarial delivery to inflammatory P1328 132.2 MAP4K3/GLK-induced AhR-RORgt complex cells driving lupus pathogenesis using shape-based targeting is a novel therapeutic target for GLKhighIL-17Ahigh nanoparticles. M. Allen, N. Karabin, A. Golding, E. Scott and subpopulation of SLE patients. H-C. Chuang and T-H. Tan. G. Szeto. Univ. of Maryland, Baltimore County, Northwestern Natl. Hlth. Res. Inst. Univ. and Univ. of Maryland Sch. of Med. P1329 132.3 Response Gene to Complement -32 exerts P1326 132.16 De novo fatty acid synthesis induced Sjogren¨ ’s proinflammatory and profibrotic effects in immune complex syndrome by promoting Th17 differentiation. J. Luo and Z. Yin. mediated glomerulonephritis. V. Rus, A. Tatomir, Jinan Univ., China. V. Nguyen, A. Talpos-Caia, J. Papadimitriou, S. Atamas, S P1337 132.17 Single-target pan-liver autoimmune disease- I. Luzina, S-S.J. Sung, T. Badea and H. Rus. Univ. of A suppressing nanomedicines. C. Sokke Umeshappa, S. Singha, Maryland Sch. of Med., Univ. of Virginia Sch. of Med. and T J. Blanco, K. Shao, R. Hebbandi Nanjundappa, J. Yamanouchi, NEI, NIH. A. Pares, P. Serra, Y. Yang and P. Santamaria. Univ. of Calgary, P1330 132.4 A rationally engineered DNase1-Fc fusion Canada, Institut D’Investigacions Biomediques` August Pi i Sunyer, protein ameliorates autoimmune glomerulonephritis. Spain and Univ. of Barcelona, Spain. M. Mouchess, E. Suto, S. Chan, B. Dai, C. Tam, Y. Cao, M. Darwish, D. He, S. Haller, J. Eastham-Anderson, Y. Franke, C. Blanchette, W. Lee, C. Austin, R. Lazarus 133. TREATMENT STRATEGIES IN AUTOIMMUNE and T. Yi. Genentech, Inc. ARTHRITIS AND RELATED P1335 132.5 Type II NKT cells directed immune regulatory INFLAMMATORY DISORDERS mechanism(s) control spontaneous lupus nephritis in mice. Poster Session I. Maricic, R. Halder, I. Marrero, D.H. Kono and V. Kumar. Univ. of California, San Diego and Scripps Res. Inst. SAT. 2:30 PM—EXHIBIT/POSTER HALL P1340 132.6 Targeting T cell activation and lupus P1343 133.1 Human gingival tissue-derived MSC suppress autoimmune phenotypes with a novel glucose transporter osteoclastogenesis and bone erosion via CD39-adnosine inhibitor. W. Li, G. Qu, S-C. Choi, C. Cornaby, A. Titov, signal pathway in autoimmune arthritis. S.G. Zheng, Y. Luo X. Teng, H. Wang and L. Morel. Univ. of Florida and RenJi and J. Wang. Penn State Col. of Med. Hosp., Sch. of Med., Shanghai Jiaotong Univ., China. P1351 133.2 Development of citrullinated-vimentin-specific P1341 132.7 Validation of lanthionine synthetase C-like 2 CAR for targeting Tregs to treat autoimmune rheumatoid (LANCL2) as a therapeutic target for systemic lupus arthritis. C. Raffin, Y. Muller, J. Barragan, Y. Zhou, erythematosus. A. Leber, R. Hontecillas, V. Zoccoli- L. Piccoli, A. Lanzavecchia, S.U. Tareen, J.D. Fontenot Rodriguez and J. Bassaganya-Riera. Landos Biopharma. and J.A. Bluestone. Univ. of California, San Francisco, IRB P1342 132.8 A nanoparticle-based approach targeting ion Barcelona, Spain, Inst. for Res. in Biomed., Switzerland and channels for the treatment of Lupus nephritis. A.A. Chimote, Juno Therapeutics. M. Khodoun, H.J. Duncan, S.K. Kant and L. Conforti. Univ. P1359 133.3 Identification of potent RORc inhibitors for the ’ of Cincinnati and Cincinnati Children s Hosp. Med. Ctr. treatment of IL-17-mediated inflammatory diseases: is it worth P1331 132.9 Angiotensin-converting enzyme inhibitor the risk? C. Everett, J. Zbieg, O. Rene, S. Rutz, W. Lee, suppresses type I interferon responses, decreases S. Laing, J. Zhang, A. Johnson, N. Ghilardi, J. Crawford fl neuroin ammation and improves depression-like behavior in and C. Eidenschenk. Genentech, Inc. and Novartis Institutes MRL/lpr lupus-prone mice. U. Sriram, C. Nocito, M. Hand, of Biomed. Res. fi C. Lubinsky, A. Seliga, V. Zuluaga-Ramirez, M. Win eld P1345 133.4 Therapeutic vaccination by two DerG LEAPS and Y. Persidsky. Lewis Katz Sch. of Med., Temple Univ. conjugates incorporating different PG (aggrecan) epitopes fl P1332 132.10 Expression of interferon genes is in uenced by protect by different immune mechanisms in the PG G1 sex hormones in SLE. R.P. Singh and B.H. Hahn. VA Greater domain induced mouse model of rheumatoid arthritis. Los Angeles Hlth. Care Syst. and David Geffen Sch. of Med., D.H. Zimmerman, K. Mikecz, K.S. Rosenthal, Univ. of California, Los Angeles. A. Markovics, R. Carambula, J. Ciemielewski and P1333 132.11 Lupus mice treated with Lupresan decreased T. Glant. CEL-SCI Corporation, Rush Univ. Med. Ctr. and autoantibody titers and improve facial lesions. C. Wong Roseman Univ. of Hlth. Sci. Baeza, A. Resendiz´ Mora, M. Figueroa Pensado, S. Vela P1350 133.5 Interleukin-17 drives interstitial entrapment of ı Patiño, G. Nava Estrada, C. Wong Ram´rez and I. Baeza tissue lipoproteins in experimental psoriasis. P. Huang, ı Ram´rez. Instituto Politecnico Nacional, Mexico. B. Zinselmeyer, B.T. Saunders, M.A. Swartz, B.S. Kim P1334 132.12 Alpha-1-antitrypsin ameliorates diffuse and G.J. Randolph. Washington Univ. Sch. of Med. and alveolar hemorrhage in the pristane induced lupus model. Univ. of Chicago. A.S. Elshikha, G. Abboud, A. Danos, M. Chen, Y. Yuan, L. Zeumer, L. Morel and S. Song. Col. of Pharmacy, Univ. of Florida and Col. of Med., Univ. of Florida.

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P1353 133.6 Restraining neuroinflammation during antigen P1360 133.18 MyD88 and PKD1 play an essential role in the delivery as an immunosuppressive approach to prevent and development of spontaneous polyarthritis in IL-1 receptor treat contact dermatitis. M. Bandyopadhyay, A.E. Morelli, antagonist-deficient mice. T. Yoon, H. Cho, J.M. Stuart and G. Erdos, T.L. Sumpter, O.A. Tkacheva, W.J. Shufesky, A-K. Yi. The Univ. of Tennessee Hlth. Sci. Ctr. and Veterans L.D. Falo and A.T. Larregina. Univ. of Pittsburgh Sch. of Med. Affairs Med. Ctr. and Univ. of Pittsburgh Med. Ctr. P1344 133.7 Targeting chemokine receptors CCR6 and 134. CELLULAR THERAPIES FOR CANCER CXCR2 in a murine model of IL-36a-induced pustular psoriasis. J.J. Campbell, K. Ebsworth, L. Ertl, Poster Session J.P. McMahon, Y. Wang, S. Yau, V.R. Mali, V. Chhina, SAT. 2:30 PM—EXHIBIT/POSTER HALL A. Kumamoto, S. Liu, T. Dang, D. Newland, I.F. Charo, fi P. Zhang, T.J. Schall and R. Singh. ChemoCentryx, Inc. P1361 134.1 Identifying and engineering TCR speci city P1346 133.8 1,25-Dihydroxyvitamin D3 ameliorates against solid tumor neoantigens. M.S. Naradikian, collagen-induced arthritis via suppression of Th17 cells L. Montero, S. Hall, R. Thota, A. Frentzen, M. Bahmanof, through miR-124 mediated inhibition of IL-6 signaling. L. Sternberg, J. Lane, Z. Kosaloglu-Yalcin, M. Lanka, S.G. Zheng, L. Zhou and J. Wang. Penn State Col. of Med. A. Miller, B. Peters, E. Cohen and S. Schoenberger.La P1347 133.9 An accidental discovery of a new potential Jolla Inst. for Allergy and Immunology and Univ. of California, mouse model of the axial spondyloarthritis . N.K. Banda. San Diego. + fi Univ. of Colorado, Denver AMC. P1363 134.2 CAR T cell anti-tumor ef cacy revealed by fi P1348 133.10 Immunoregulatory effects of mesenchymal multi-dimensional single-cell pro ling. X. An, G. Romain, stem cells-derived exsomes in a rabbit model of M. Martinez-Paniagua, I.N. Bandey, J.RT. Adolacion, autoimmune dacryoadenitis. H. Nian, N. Li, Y. Wei, M. Fathi, I. Liadi, F. Sadeghi, A. Mahendra, A. Amritkar, L. Zhao, S. Chen and R. Wei. Tianjin Med. Univ., China. B. Roysam, H. Singh, L.J. Cooper and N. Varadarajan. Univ. P1349 133.11 N-acetylcysteine reduces reactive oxygen of Houston, Univ. of Texas MD Anderson Cancer Ctr. and species and pro-inflammatory cytokine production in HLA- Ziopharm Oncology. B27-positive macrophages and shapes them towards a P1365 134.3 Disruption of TOX transcription factors quiescent metabolic state. F. Navid, B. Nguyen, enhances CAR T cells function in solid tumors. H. Seo, A. Cougnoux, P-C. Violet, M. Levine and R.A. Colbert. J. Chen, E. Gonzalez Avalos, D. Samaniego Castruita, NIAMS, NIH, NICHD, NIH and NIDDK, NIH. I. Lopez Moyado, C-J. Wu, A. Das, L-F. Lu, A. Bhandoola P1352 133.12 C15 is an actionable drug target for anti- and A. Rao. La Jolla Inst. for Immunology, Univ. of California, arthritis via activation Nrf2 signaling. T. Li, K. Liao, San Diego and NCI, NIH. Y. Zhuang, J. Wu and J. Liu. State Key Lab. of Quality P1372 134.4 Intratumoral localization of pattern recognition Res. in Chinese Med., Macau. receptor signaling informs CAR T cell design. L. Johnson, P1354 133.13 Increased lymphatic circulation decreases C.H. June and A.J. Minn. Univ. of Pennsylvania. CD4 counts in the lymph nodes of rats in adjuvant-induced P1370 134.5 CD28 homolog is a strong activator of natural arthritis. M.A. Swanson-Mungerson, M. Magnuson, killer cells for lysis of B7H7-positive tumor cells. X. Zhuang and M-K. Chang, D. Hager, S. Sperrazza, B. Zanotti, E.O. Long. NIAID, NIH. fi R. Incrocci and M.V. Volin. Midwestern Univ. P1368 134.6 Integrated pro ling of T cells and tumor cells P1355 133.14 Inhibition of dendritic cells and Th17 cells by a demonstrates metabolic adaptation essential for melanoma flavonoid compound attenuates clinical severities in a murine cell therapy. M.A. Martinez-Paniagua, C. Haymaker, collagen-induced arthritis model. H-R. Yen, F-T. Pai and J.R.T. Adolacion, X. An, I.N. Bandey, C. Creasy, C-Y. Lu. Sch. of Chinese Med., China Med. Univ., Taiwan, T. Geiger, M. Harel, J. Robinson, J.B. Nielsen, Chang Gung Univ., Taiwan and Chang Gung Mem. Hosp., A. Amritkar, S. Woodman, B. Roysam, P. Hwu, Taiwan. C. Bernatchez and N. Varadarajan. Univ. of Houston, P1356 133.15 The potential role for berberine, an alkaloid Univ. of Texas MD Anderson Cancer Ctr., Tel Aviv Univ., dietary supplement, in mitigating the subclinical pathology Israel and Chalmers Univ. of Technol., Sweden. and delaying onset of rheumatoid arthritis. A.A. Vita, P1379 134.7 Robust antitumor effects of SNA-based T cell N.A. Pullen and D. Lyons. Univ. of Northern Colorado. therapy. D. Dominguez, N. Chernyak, M. guan, Y. Chou, P1357 133.16 Small molecule inhibitor suppresses Tfh cell A. Long, L. Qin, L. Cole, J. Ann, S. Chen, J. Fan, A. Lee, development in germinal center and reduces the severity of C. Mirkin and B. Zhang. Northwestern Univ. inflammation in a collagen-induced arthritis mouse model. P1362 134.8 Effects of structural changes of beta- X. Zhang, N. Bhatia, F. Migliore, L. Hellmers, G. Olayemi, mannosylceramide on activation of invariant natural killer C. Mcleod, J. Zakem, W. Davis and R. Quinet. Ochsner Med. T cells and stimulation of anti-tumor immunity. J. Yau, Ctr. and Inst. of Translational Res., Ochsner Med. Ctr. S. Robinson, B. Compton, D. Larsen, G. Painter, P1358 133.17 Investigational treatment of rheumatoid J.A. Berzofsky and M. Terabe. NCI, NIH, Univ. of Otago, arthritis with a vibrotactile device applied to the external ear. Dunedin, New Zealand and Victoria Univ. of Wellington, G.H. Imperato, M.E. Addorisio, V.A. Pavlov, H. Yang, Wellington, New Zealand. B. Diamond, K.J. Tracey and S.S. Chavan. Feinstein Inst. P1364 134.9 Expression of a neoantigen renders pancreas for Med. Res. cancer transiently susceptible to immunotherapy. A.L. Burrack, E. Spartz, J. Raynor, M. Olson and I. Stromnes. Univ. of Minnesota.

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P1366 134.10 Reconstitution of iNKT cells enhances 135. MACROPHAGES AND MYELOID AND antitumor immunity through liver education of iNKT cells and DENDRITIC CELLS IN TUMOR IMMUNITY modulation of tumor microenvironment. H. Zhang, Z. Zhu, AND IMMUNOTHERAPY F. Zhang and S. Modrak. Col. of Pharmacy and Pharmaceutical Sci., Washington State Univ. Poster Session P1367 134.11 Substitution of alpha aminobutyric acid for SAT. 2:30 PM—EXHIBIT/POSTER HALL cysteine at class I MHC anchor positions can enhance recognition of cancer epitopes. A.E. Sachs, B. Peters, P1507 135.1 Paradoxical pro-tumor functions of dendritic J. Sidney, A. Sette, S.A. Rosenberg and P.F. Robbins. cells on colorectal cancer. H-I. Huang and G. Hammer. NCI, NIH and La Jolla Inst. for Immunology. Duke Univ. P1369 134.12 Cancer stem cells inhibit NK cell effector P1509 135.2 The role of neutrophil extracellular traps in function via PCNA-NKp44 interaction. J.D. Malaer and nonalcoholic steatohepatitis-associated hepatocellular P.A. Mathew. Morehouse Sch. of Med. and Univ. of North carcinoma. H. Zhang, D.J. van der Windt, J. Ren, Texas Hlth. Sci. Ctr. A. Tsung and H. Huang. Ohio State Univ., Wexner Med. P1371 134.13 Pulsatile MEK inhibition improves anti-tumor Ctr. and Univ. of Pittsburgh Med. Ctr. immunity and T cell function in Kras mutant lung cancer. P1515 135.3 Non-small cell lung cancer tumor H. Choi, J. Deng, S. Li, T. Silk, L. Dong, E.J. Brea, microenvironment induces arginase1 in neutrophils via the S D.C. Redmond, S. Houghton, N. Falik, J. Boiarsky, toll-like receptor 2 signaling pathway. H. Zhang, J. Kargl, X. Zhu, X. Wang, J. Cao and A.M. Houghton. Fred A H. Zhong, E.A. Akbay, P.D. Smith, T. Merghoub, T K-K. Wong and J.D. Wolchok. Mem. Sloan Kettering Hutchinson Cancer Res. Ctr. and Med. Univ. of Graz, Austria. Cancer Ctr., New York Univ. Med. Ctr., Univ. of Texas P1513 135.4 Single cell RNA sequencing reveals distinct Southwestern Med. Ctr. and AstraZeneca, Ltd, United gene expression signatures of myeloid-derived suppressor Kingdom. cells in breast cancer. H. Alshetaiwi, N. Pervolarakis, P1373 134.14 De novo DNA methylation programs regulate L.L. McIntyre, D. Ma, Q. Nguyen, K. Nee, J. Rath, T cell exhaustion and limit T cell-based immunotherapies. K. Evans, L. Torosian, A. Silva, C. Walsh and B.A. Youngblood, H.E. Ghoneim, H.A. Abdelsamed, K. Kessenbrock. Univ. of California, Irvine, Sch. of Med., A. Moustaki, Y. Fan, J. Crawford, P.G. Thomas, Univ. of California, Irvine, Sch. of Bio. and Univ. of E. Stewart and S. Federico. St. Jude Children’s Res. Hosp. California, Irvine, Sch. of Hlth. and Pharmaceutical Sci. fi P1375 134.15 REAlease® immunomagnetic separation P1514 135.5 The cross-talk between in ltrating fl technology with reversible labeling for tumor infiltrating macrophages and in amed or malignant colonic epithelium T cells and sub-populations. C. Evaristo, R. Siemer, promotes overexpression of ST6GALNAC1 and epithelial D. Agorku, J. Brauner, O. Hardt, C. Dose and A. Richter. MUC1 tumor form MUC1-sTn. S. Cascio, M. Kvorjak, Miltenyi Biotec, Germany. Y. Ahmed, M. Miller, J. Al Hashash, D. Hartman, P1376 134.16 Ex vivo phenotyping and potency monitoring of N. Miskov-Zivanov, C. Telmer and O.J. Finn. Univ. of CD19 CAR T cells with a combined flow cytometry and Pittsburgh Sch. of Med. and Carnegie Mellon Univ. fi + impedance-based real-time cell analysis workflow. M. Lei, P1518 135.6 The fate of leukemia-speci c CD8 T cell fi P. Ye, Y. Lu, X. Ji, A. Wang, N. Li and X. Wang. ACEA clones is dictated by antigen speci city and the mechanism Biosciences. of cognate antigen presentation. X. Chen, B. Flood, P1377 134.17 Harnessing the anti-tumor activity of invariant B. MacNabb, B.R. Blazar and J. Kline. Univ. of Chicago natural killer T cells for neuroblastoma immunotherapy. and Univ. of Minnesota. P. Khurana, G. Ferry, S. Karageorgos, A. Vu, P1521 135.7 Tumor-derived retinoic acid promotes immune K. McNerney, M. Hogarty and H. Bassiri. Children’s Hosp. suppression in sarcoma. S. Devalaraja, T. To, I. Folkert, M. Li, of Philadelphia. Y. Tada and M. Haldar. Perelman Sch. of Med., Univ. of P1378 134.18 Targeted ablation of FoxP3+ T cells activates Pennsylvania. peripheral and tumor-infiltrating cytotoxic CD8+ T cells in P1525 135.8 ST8Sia6 overexpression accelerates tumor multiple syngeneic mouse tumor models. T. Delfino, growth, alters macrophage polarization and the immune Y. Wang, J. Schartner and S. Rutz. Genentech, Inc. response. D.J. Friedman, M. Shapiro, M. Rajcula, P1500 134.19 Phenotypical and functional analysis of natural S. McCue and V. Smith Shapiro. Mayo Clin. Grad. Sch. of killer cells from primary human head and neck squamous cell Biomed. Sci. carcinomas. M.J. Korrer and Y. Kim. Vanderbilt Univ. Med. P1501 135.9 A mixed phenotype of tumor-associated Ctr. macrophages and neutrophils is evident within hours of P1374 134.20 Two morphological changes of cancer cells murine mammary carcinoma delivery. R.A. Kurt, C. Zhang, under natural killer cell killing. Y.J. Choi, G.B. Ahn, J. Schwartz, A. Lauricella, M. Adusei, M. DeBenedetto and H.S. Kim, H.K. Lee, Y. Kim, J.T. Hong and S-B. Han. C. Newsom-Stewart. Lafayette Col. Chungbuk Natl. Univ., South Korea. P1502 135.10 The immune suppressive role of DC-derived IL-27 in hepatocellular carcinoma via the modulation of gut microbiota. H. Liu, Y. Liu and Y. Song. National Univ. of Singapore, Singapore. P1503 135.11 LincRNA-p21 knockdown reversed the Share your experiences on social media. functional phenotype of macrophage in tumor Tag your posts with the official meeting hashtag: microenvironment by modulating its interaction with p53 and #AAI2019 ameliorated breast cancer development. Z. Su, L. Zhou, R. Chen, H. Lu and H. Xu. Jiangsu Univ., China.

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P1504 135.12 Monocyte-lineage dendritic cell precursors are P1524 135.25 Mesenchymal stem cells educate breast tumor pre-positioned in normal lymph nodes and rapidly differentiate associated macrophages to acquire increased into Batf3+ cross-presenting APCs during inflammation. immunosuppressive features. S. Biswas, G. Mandal, M.D. Sharma. Augusta Univ. S. Roy Chowdhury, S. Purohit, K.K. Payne, C.M. Anadon P1505 135.13 Exosomal communication by metastatic Galindo, A. Gupta, X. Yu, J.R. Conejo-Garcia and osteosarcoma cells contributes to the modulation of alveolar A. Bhattacharyya. Moffitt Cancer Ctr. and Res. Inst., Univ. macrophages to an M2 tumor-promoting phenotype. of Calcutta, India and Saroj Gupta Cancer Centre and Res. K.K. Wolf-Dennen, N. Gordon and E.S. Kleinerman. Univ. Inst. of Texas MD Anderson Cancer Center. P1526 135.26 Inflammasome signaling mediates myeloid P1506 135.14 Knockout immune regulator FGL2 in tumor immunosuppression within the tumor microenvironment. cells impairs tumor progression in the CNS by facilitating C.N. Lang and Y. Kim. Vanderbilt Univ. and Vanderbilt CD103+ dendritic cell differentiation. J. Yan, Q. Zhao, Univ. Med. Ctr. K. Gabrusiewicz, L-Y. Kong, X. Xia, J. Wang, M. Ott, P1527 135.27 Effector T cell stimulation using J. Xu, E.R. Davis, L. Huo, G. Rao, S-C. Sun, Staphylococcal enterotoxin G and I loaded HLA transgenic S.S. Watowich, A.B. Heimberger and S. Li. Univ. of Texas dendritic cells. P.L. Knopick, N. Riha, N. Biswas, M. Nilles MD Anderson Cancer Ctr. and D.S. Bradley. Univ. of North Dakota. P1508 135.15 Frequency of myeloid derived suppressor cells P1528 135.28 Inhibition of effective anti-tumor immunity by in spleen and peripheral blood from cancer patients. macrophage Bcl6. N.N. Desai, B. Zhu, Y.M. Son and J. Sun. J.E. Talmadge, K. Cole, Q. Ly, M. Hollingsworth and Mayo Clin. Grad. Sch. of Biomed. Sci. and Mayo Clin. Col. of J. Cox. Univ. of Nebraska Med. Ctr. Med. and Sci. P1510 135.16 Dendritic cells dysfunction in tumor-draining P1529 135.29 The IRE1-XBP1 axis controls the tumorigenic lymph nodes. J.M. Bandola-Simon and P.A. Roche. NCI, properties of macrophages. M. Zanetti. UCSD Moores Cancer NIH. Ctr. P1511 135.17 CDDO-Me redirects macrophage activation. P1530 135.30 Myeloid derived suppressor cells promote G.M. Torres Santiesteban, T. Shabaneh, R. Bhandari, ovarian cancer progression in a murine model of ovarian K. Liby, M.J. Turk and P. Pioli. Dartmouth Geisel Sch. of cancer. R. Rattan, S. Sakr, S. Dar, T. Buekars, R. Morris, Med. and Michigan State Univ. A. Munkarah and S. Giri. Henry Ford Hlth. Sys. and Wayne P1512 135.18 Cannabinoids decrease intestinal permeability State Univ. Sch. of Med. and induce colonic CD103+ dendritic cells to increase T regulatory cells leading to decreased murine colitis- 136. COMBINATION THERAPIES associated colon cancer. W.J. Becker, H. Alrafas, FOR IMMUNO-ONCOLOGY M. Nagarkatti and P.S. Nagarkatti. Univ. of South Carolina Sch. of Med. Poster Session P1516 135.19 A novel CSF-1R neutralizing antibody, DCB- SAT. 2:30 PM—EXHIBIT/POSTER HALL AB21, inhibits colony-stimulating factor 1 receptor signaling activity. C-H. HO, C-B. Liao, Y-K. Chen, C-W. Huang and P1539 136.1 Inhibition of SHP-1 expands the repertoire of T-P. Yang. Develop. Ctr. for Biotechnology, Taiwan. anti-tumor T cells available to respond to checkpoint blockade P1517 135.20 A lipid-mediated paracrine signaling network therapy. J. Snook, A. Soedel and M.A. Williams. Univ. of stimulates tumor-associated macrophage development in Utah. cancer and metastasis. V. Rai and R. Ray. Inst. of Life Sci., P1549 136.2 Enhanced antitumor effects by combining IL- Bhubaneswar, India. 12 gene electrotransfer with anti-PD1 in preclinical metastatic P1519 135.21 Dendritic cells present cancer-derived p:MHCI cancer model. G. Shi, C. Lundberg, M. Scott, C. Edelblute molecules to prime anti-tumor CD8 T cells. B. MacNabb, and R. Heller. Old Dominion Univ. D. Kline, X. Chen, S. Tumuluru and J. Kline. Univ. of P1550 136.3 CD122-selective IL-2 complexes synergize KO Chicago. with anti-PD-L1 in B16 melanoma to treat PD-L1 tumors, + + - - + + P1520 135.22 The effects of a CRISPR/Cas9 IL-6 knockout in possibly through inducing CD8 TCF-1 Tim3 PD 1 CXCR5 4T1 mammary carcinoma cells on myeloid-derived suppressor stem-like T cells. X. Zhang, J.M. Drerup, J. Mendez, cells and Th17/Th22 cells. V.J. Rase, J.M. Haughian and A.S. Padron, Y. Deng, H.B. Gupta and T.J. Curiel. First fi N.A. Pullen. Univ. of Northern Colorado. Af liated Hosp., Sun Yat-sen Univ., China and UTHealth, P1522 135.23 Immune microenvironment landscape and the San Antonio. role of neutrophils in glioblastoma. D. Friedmann-Morvinski, P1543 136.4 Increasing intratumoral dendritic cells to P. Magod, L. Agemy and L. Rousso-Noori. Tel Aviv Univ. potentiate anti-tumor effects of Newcastle disease virus- and Weizmann Inst. of Sci. based immunotherapy. J. Svensson-Arvelund, P1523 135.24 MIF functional polymorphisms (-794 CATT S. Cuadrado-Castano, L. Hammerich, M. Yellin, 5-8 ı and -173 G>C) in basal cell carcinoma in western Mexican H. Marsh, B.D. Brown, A. Garc´a-Sastre and J. Brody. population. E. Valdes´ Alvarado, J. Padilla Gutierrez, Icahn Sch. of Med., Mount Sinai and Celldex Therapeut. Y. Valle, M. Pedroza Gonzalez,´ D.E. Martinez-Fernandez, P1531 136.5 Immunodominant and cryptic tumor fi J.F. Muñoz Valle, E. Guevera and A. Tlacuilo. Universidad neoantigen-speci c immune responses activated by an de Guadalajara. armed oncolytic virus expressing a PD-L1 inhibitor. G. Wang. Univ. of Southern California.

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P1547 136.6 Influenza vaccination administered in the P1542 136.16 Soluble FasL deficiency promotes CD8 T cell tumor induces an inflamed tumor microenvironment and dependent elimination of primary intraocular tumors and liver reduces tumor growth. J.H. Newman, B. Chesson, metastases. K.C. McKenna, P. McCullough, D. Durbin, N. Herzog, P. Bommareddy, S. Aspromonte, R. Pepe, G. O’Brien, M. McDermott and A. Marshak Rothstein. R. Estupinian, M. Aboelatta, S. Buddhadev, J. Schenkel, Franciscan Univ. of Steubenville and Univ. of Massachussetts. P. Thomas, J. Rudra, A. Silk and A. Zloza. Rutgers Cancer P1544 136.17 Patient-derived, vaccine-elicited MUC1 Inst. of New Jersey, Univ. of Texas MD Anderson Cancer Ctr., antibodies mediate immune effector functions against cancer Massachusetts Inst. of Technol., St. Jude Children’s Res. cells. M.L. Miller, J. Lohmueller, E. Ricci, W. Lu and Hosp., Washington Univ., St. Louis, Harvard Med. Sch. and O.J. Finn. Univ. of Pittsburgh Sch. of Med. Rush Univ. Med. Ctr. P1545 136.18 Bortezomib improves antitumor CD8+ T cell P1533 136.7 Activation of human immune cells with cowpea function by modulating miR-155 and its targets. mosaic virus. M.M. Albakri, V. Beiss, S.N. Fiering, A.N. Renrick, M. Thounaojam, E. Chaudhuri, C. Dash N.F. Steinmetz and S.F. Sieg. Case Western Reserve and A. Shanker. Meharry Med. Col. and Augusta Univ. Univ., Univ. of California, San Diego and Dartmouth Geisel P1546 136.19 Ibrutinib, but not acalabrutinib, inhibits anti- Sch. of Med. lymphoma T cell and NK cell function. L. Hammerich, P1536 136.8 Cold ...isnotsocold: CD4+ T cells are active J. Svensson-Arvelund, T. Covey and J. Brody. Icahn but suppressed in colorectal cancer. J.M. Jessup. Inova Schar Sch. of Med., Mount Sinai and Acerta Pharma B.V. S Cancer Inst. P1548 136.20 DeepTM IL-15 primed T cells avoid toxicity and A fl P1532 136.9 Targeting DAMP-induced in ammation to synergize with PD-L1 blockade to overcome checkpoint T prevent breast cancer metastasis and improve anti-tumor resistance in cancer. K. Sauer, E. Geretti, X. Liang, immunity. V.G.N. Frazier, E. Holl, D. Boczkowski, J. Lyons, P. Bardwell, S. Caruso, B. Hewes, J. Fitzgerald B. Sullenger and S.K. Nair. Duke Univ. Sch. of Med. and T. Andresen. Torque Therapeutics. P1534 136.10 Influence of immune-checkpoint inhibitor and P1551 136.21 Guadecitabine, in combination with a TLR9 HLA-G in patients with cervical cancer. J.C.O. CRISPIM- agonist, promotes anti-cancer immunity in BALB/c mice FREITAS, R.S.P. Morais, V.S. Oliveira, I. Sadissou, bearing 4T1 mouse mammary carcinoma. T.M. Smith and G.M. Palomino, R.N.O. Cobucci, G.A. Lira, R. Martin. Virginia Commonwealth Univ. Sch. of Med. K.T.C. Carvalho, E.B.O. Silva, N.L. Silva and P1552 136.22 Synergistic activity between IL-15 signaling E.A. Donadi. Federal Univ. of Rio Grande do Norte, Natal, and checkpoint blockade drives enhanced NK cell Brazil, Ribeirão Preto Sch. of Med., Univ. of São Paulo, Brazil, expansion and tumor control in ovarian cancer. M. Felices, Maternity Sch. Januario´ Cicco, Natal, Brazil, Hospital Cancer L. Bendzick, B. Kodal, P. Hinderlie, J.S. Miller and Dr. Luiz Antonio, Natal, Brazil and Center of Search Aggeu M. Geller. Univ. of Minnesota. Magalhães, Recife-PE, Brazil. P1553 136.23 Isoform specific anti-TGFb therapy enhances P1535 136.11 Low dose radiotherapy promotes immune- antitumor efficacy in mouse models of cancer. S. Budhu, mediated anti-tumor responses. H.B. Barsoumian, A. Gupta, R. Giese, J. van Snick, C. Uyttenhove, A.I. Younes, R. Ramapriyan, M.S. Caetano, G. Ritter, J.D. Wolchok and T. Merghoub. Mem. Sloan J.E. Schoenhals, H. Menon, T.R. Cushman, A. Cadena, Kettering Cancer Ctr. and Ludwig Inst. for Cancer Res. A. Li, M.A. Cortez and J.W. Welsh. Univ. of Texas MD P1554 136.24 Glycogen synthase kinase 3 synergizes with Anderson Cancer Ctr. immune-checkpoint blockade to overcome tumor resistance P1537 136.12 Isorhapontigenin shows strong anti-melanoma due to unique tumor infiltrating T-cell subsets as revealed by cell activity, and induces anti-tumor immunity. Y. Song, Z. Yu, mass cytometry. J. Krueger, A. Taylor, V. Motta, J. Stagg, C. Tong, M. Liu, X. Jiang, Y. Zeng and C. Chen. China Three I. Watson and C.E. Rudd. Universite´ de Montreal,´ Canada, St. Gorges Univ. Med. Sch., China. James’s Univ. Hosp., Fluidigm, Centre de Recherche du CHU P1538 136.13 IL-15 enhances anti-PD-1-induced de Montreal,´ Canada and McGill Univ., Canada. reinvigoration of tumor-infiltrating CD8+ T cells. G. Leem, P1555 136.25 Pathology of B cell and neutrophil infiltration in K.W. Kim, J-I. Lee, S.Y. Ha, S-H. Park, S.M. Kang and the YUMMER1.7 mouse model of spontaneous melanoma E-C. Shin. Korea Advanced Inst. of Sci. and Technol., tumor regression. K.R.M. Blenman, J. Wang, S. Cowper South Korea and Gachon Univ. Gil Med. Ctr., South Korea. and M. Bosenberg. Yale Univ. Sch. of Med. P1540 136.14 Selective IL-2 receptor b (CD122) targeting P1556 136.26 Harnessing alloreactive responses by patient improves aPD-L1 immunotherapy in a metastatic bladder lymphocytes to achieve anti-cancer responses. L.D. Fast, cancer model. R.M. Reyes, D. Zhang, Y. Deng, A. Pando and J.L. Reagan. Rhode Island Hosp. and Brown N. Mukherjee, N. Ji, H.B. Gupta, R.S. Svatek and Univ. T.J. Curiel. Univ. of Texas Hlth. Sci. Ctr., San Antonio. P1557 136.27 Mandated cool housing temperature and P1541 136.15 CD122-selective IL-2 complexes treat ovarian adrenergic stress reduce the efficacy of radiation and mask carcinomas and melanoma, alter Treg differentiation and the “abscopal effect” in mouse models of cancer. M. Chen, induce more CD8+CXCR5+TCF-1+ stem T cells when G. Qiao, B.L. Hylander, H. Mohammadpour, A.K. Singh and combined with aPD-L1. Y. Deng, H.B. Gupta, J.M. Drerup, E.A. Repasky. Roswell Park Cancer Inst. R.M. Reyes, J. Mendez, X. Zhang, A.S. Padron, M. Garcia and T.J. Curiel. Univ. of Texas Hlth. Sci. Ctr., San Antonio and Sun Yat-sen Univ.

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137. IMMUNOMETABOLISM IN TUMOR IMMUNITY P1569 137.12 Peroxynitrite affects MHC I peptide repertoire AND IMMUNOTHERAPY presented on tumor cells and impedes the efficacy of antitumor cytotoxic T-lymphocytes. E. Tcyganov and D.I. Gabrilovich. Poster Session The Wistar Insitute. SAT. 2:30 PM—EXHIBIT/POSTER HALL P1570 137.13 Mature neutrophils acquire a T cell suppressor phenotype in the ovarian cancer microenvironment that P1561 137.1 Fatty acid depletion is a reversible cause of requires complement and NADPH oxidase activation. kynurenine induced T cell apoptosis. U.H. Beier, M.D. Cully, T.R. Emmons, K.L. Singel, A.N.M.N. Khan, E. Alqassim, P.J. Siska, K. Singer, J. Jiao, T. TeSlaa, W.J. Quinn, A.M. Blom, S. Ram, S. Holland, K. Odunsi, E. Zsiros and W.W. Hancock, J.A. Baur, J.D. Rabinowitz and B.H. Segal. Roswell Park Cancer Inst., Lund Univ., Univ. of M. Kreutz. Univ. of Pennsylvania, Univ. Hosp. Regensburg, Massachusetts Med. Sch. and NIAID, NIH. ’ Germany, Children s Hosp. of Philadelphia and Princeton Univ. P1571 137.14 Regulation of cancer playmaker survival: P1563 137.2 Tumor cell IDO1 increases intratumoral increased neutrophil life span by the action of cancer immunosuppressive Tregs independent of enzyme activity. derived a2 V-ATPase. S.A. Ibrahim, A. Kulshrestha, L. Zhai, A. Bell, J. Qian, E. Ladomersky, K.L. Lauing and G.K. Katara, M. Sahoo and K.D. Beaman. Chicago Med. D.A. Wainwright. Feinberg Sch. of Med., Northwestern Univ. Sch., Rosalind Franklin Univ. of Med. and Sci. P1568 137.3 Blockade of IDO/TDO downstream effectors P1572 137.15 Glucocorticoid signaling regulates CD8+T cell restricts cancer immune suppression. L.F. Campesato, responses in cancer. N. Acharya, A. Madi, H. Zhang, S. Budhu, J. Tchaicha, A. Jaiswal, M. Gigoux, S. Pourpe, M. Klapholz, E. Christian, K.O. Dixon, D. Mangani, J. Xia, C. Liu, D. Zamarin, M.G. Manfredi, K. McGovern, M. Singer, O. Rozenblatt-Rosen, A. Regev, V.K. Kuchroo J.D. Wolchok and T. Merghoub. Mem. Sloan Kettering and A.C. Anderson. Brigham and Women’s Hosp., Harvard Cancer Ctr. and Kyn Therapeutics. Med. Sch. and Broad Inst. of MIT and Harvard. P1562 137.4 Dynamics of migration patterns of polymorphonuclear myeloid-derived suppressor cells during tumor progression. S. Fu, S. Patel, J. Mastio, 138. RESIDENT MEMORY IN G.A. Dominguez, K.A. Torres, Y. Nefedova, J. Zhou and TUMOR IMMUNOTHERAPY D.I. Gabrilovich. Wistar Inst. and Sun Yat-sen Univ., China. Poster Session P1564 137.5 Suboptimal ER stress-induced autophagy — potentiates anti-tumor T cell response. P. Chakraborty, SAT. 2:30 PM EXHIBIT/POSTER HALL

S. Chatterjee, D. Tran, S. Nadig, C. Atkinson and P1575 138.1 Resident memory (TRM) cells sustain immunity S. Mehrotra. Med. Univ. of South Carolina. to cancer at sites of frequent metastasis. A. Molodtsov, P1565 137.6 Metabolic reprogramming of arginine in tumor K. Lewis, J. Han, J. Vella, Y. Zhao, B. Malik, P. Zhang, stem cells facilitates immune escape. K-H. Chen and F. Kolling, C. Cheng, Y.H. Huang, C. Angeles and M.J. Turk. A. Walker. Univ. of California, Riverside. Geisel Sch. of Med., Dartmouth Col. P1558 137.7 Pharmacologic inhibition of liver X receptors P1577 138.2 Tissue-resident memory T cells mediate enhances T cell anti-tumor function in triple negative breast melanoma surveillance and are targets of immunotherapy. cancer. K.J. Carpenter, S. Abuirqeba, S. Majidi, S.L. Park, A. Buzzai, J.L. Hor, M. Effern, S.N. Christo, M. Sengupta, A.C. Valfort, A. Chatterjee, R.J. DiPaolo S.N. Mueller, M. Holzel, J. Waithman, L.K. Mackay and and C.A. Flaveny. Saint Louis Univ. T. Gebhardt. Univ. of Melbourne, Australia, Telethon Kids P1559 137.8 Tumor-intrinsic PD-L1 reduces actin Inst., Australia and Univ. of Bonn, Germany. cytoskeleton polymerization to promote mTORC1 signals P1603 138.3 Focal tumor ablation by irreversible driving tumor stemness. S.C. Kari, A. Kancharla, electroporation augments immunotherapy to promote tumor H.B. Gupta, A. Risinger and T.J. Curiel. Univ. of Texas growth control and formation of tumor antigen-specific tissue- Hlth. Sci. Ctr., San Antonio. resident memory CD8+ T cells. B.J. Burbach, P1560 137.9 Reprograming human Treg metabolism via S.D. O’Flanagan, M.R. Rollins, J.R. Slaughter, innate TLR signaling for tumor immunotherapy. X. Liu, L. Li, K.M. Young, M. Song, Q. Shao, S.M. Azarin, J.C. Bischof K.L. Sanders, J.L. Edwards, E.C. Hsueh, D.A. Ford, and Y. Shimizu. Univ. of Minnesota. D.F. Hoft and G. Peng. Saint Louis Univ. P1607 138.4 Immune pressure against ovarian cancer P1566 137.10 Assessing the link between epigenetics and depends on antigen-specific TRM T cells. C.M. Anadon metabolism in acute myeloid leukemia. D.L. Greenwood, Galindo, J. Perez Sanz, S. Biswas, K.K. Payne, X. Yu, H.E. Ramsey, M.Z. Madden, M.R. Savona and T.L. Costich, R. Chaurio Gonzalez and J.R. Conejo- J.C. Rathmell. Vanderbilt Univ. and Vanderbilt Univ. Med. Ctr. Garcia. Moffitt Cancer Ctr. and Res. Inst. P1567 137.11 CD8+ T cells regulate tumor ferroptosis by P1604 138.5 Sphingosine-1-phosphate receptor 1 loss targeting the system xc- during cancer immunotherapy. mediates T cell sequestration in bone marrow in the setting W. Wang, M. Green, J.E. Choi, M. Gijon,´ P. Kennedy, of intracranial tumors: a novel mode of cancer-induced P. Liao, X. Lang, I. Kryczek, A. Sell, J. Johnson, immunosuppression. D.S. Wilkinson, P. Chongsathidkiet, M. Cieslik, L. Vatan, H. Xia, J. Zhou, J. Li, G. Li, S. Wei, C. Dechant and P. Fecci. Duke Univ. Med. Ctr. H. Zhang, W. Gu, R. Liu, T. Lawrence, E. Stone, G. Georgiou, T. Chan, A. Chinnaiyan and W. Zou. Univ. of Michigan, Cayman Chem. Co., Columbia Univ. Med. Ctr., Univ. of Texas, Austin and Mem. Sloan Kettering Cancer Ctr.

78 SATURDAY—POSTER SESSIONS

P1606 138.6 Epigenetic targeting of Brd4 constrains CD8+ P1611 138.19 The death receptor Fas mediates local T cell differentiation during infection and cancer. J.J. Milner, bystander killing of antigen-negative variants by antigen- C. Toma, K. Omilusik, H. Nguyen, B. Yu, A. Delpoux, specific CD8 T cells in a heterogeneous tumor. T. Yoshida, S. Quon, A. Dey, S.M. Hedrick, K. Ozato, R. Upadhyay, A. Wroblewska, A. Baccarini, B.D. Brown S. Crotty, M.E. Pipkin and A.W. Goldrath. Univ. of and J.D. Brody. Icahn Sch. of Med. at Mount Sinai. California, San Diego, Stanford Univ., NICHD, NIH, La Jolla P1612 138.20 Characterizing unconventional T cells in the Inst. for Immunology and Scripps Res. Inst. tumor microenvironment of metastatic osteosarcoma. P1579 138.7 Therapeutic antibody discovery in lung tumors N. Appel, J. Christie and J. Blattman. The Biodesign Inst. by B cell receptor sequencing. K.J. Kramer, N. Raju, P1613 138.21 Identification of exhausted CD8+ T cells in low A. Greenplate, K. Pilewski, P. Massion and I. Georgiev. tumor mutation burden breast cancer patients. C. Egelston, Vanderbilt Univ. Med. Ctr. C.A. Avalos, D. Simons, Y. Huang, M.H. Lim and P.P. Lee. P1573 138.8 Anti-alpha-enolase T-cell response in oral Beckman Res. Inst., City of Hope. squamous cell carcinoma. J-S. Chia, C-H. Tuan, F-Y. Lay, P1614 138.22 Satb1 deficiency licenses TFH-differentiation. J-H. Ye and Y-L. Chiu. Natl. Taiwan Univ. Col. of Med., R.A. Chaurio Gonzalez, S. Biswas, K.K. Payne, Taiwan. C.M. Anadon Galindo, T. Lee Costich, A. Perales- P1574 138.9 WITHDRAWN Puchalt, J. Perez-Sanz, C.M. Harro, J.A. Mine, P1576 138.10 T cell suppression by the bone M.J. Allegrezza, N. Svoronos, J. Kroeger, J. Robinson S microenvironment increases bone metastases from breast and J.R. Conejo-Garcia. Moffitt Cancer Ctr. and Res. Inst. A cancer in mice. D.L. Arellano, A. Verdugo-Meza, and The Wistar Inst. T F. Drescher, F. Olvera-Rodriguez, P. Juarez and P. Fournier. Centro de Investigacion´ Cient´ıfica y de 139. NOVEL STRATEGIES AND THEIR FUNCTIONS Educacion,´ Mexico and Instituto de Biotecnologia, UNAM, FOR PREVENTING RESPIRATORY INFECTIONS Mexico. P1578 138.11 B cell subset changes during ovarian cancer. Poster Session J.E. Riggs, J. Maslanka, J. Londregan, N. Goldman, SAT. 2:30 PM—EXHIBIT/POSTER HALL K. DePierri and J. Somerville. Rider Univ. fi P1600 138.12 Extracellular K+ released in the tumor P1636 139.1 Metformin potentiates BCG ef cacy against microenvironment suppresses human T cell functions. Mtb infection. J. Haugen, A. Obregon-Henao, D. Ackart, N.K. Verma, S.T. Ong, X.R. Ng, A.S. Ng, W.H.S. Brandon A. Todd and R. Basaraba. Colorado State Univ. fi and K.G. Chandy. Lee Kong Chian Sch. of Med., Nanyang P1634 139.2 Mucosal delivery of nano ber booster vaccine fi Technological Univ., Singapore. enhances generation of antigen-speci c memory T cells in the P1601 138.13 Potent anti-tumor effector functions in tumor- lung parenchyma. M.A. Files, P. Bharaj, T.B. Saito, J. Rudra infiltrating MAIT and gd T cells isolated from colon cancer and J.J. Endsley. Univ. of Texas Med. Br. and Washington patients. W.C.I. Rodin, P. Sundstrom,¨ F. Ahlmanner, Univ. in St. Louis. E.B. Lindskog and M. Quiding Jarbrink¨ . Sahlgrenska P1618 139.3 Intravenous Bacille Calmette-Guerin provides Acad., Univ. of Gothenburg, Sweden. protection across a dose spectrum in a Rhesus macaque P1602 138.14 Regulatory T cells suppress the cytotoxic model of tuberculosis. J.J. Zeppa, P.A. Darrah, S. Pokkali, phenotype of T cells in intestinal tumors of APCMin/+ mice. J.A. Hackney, P.A. Maiello, C.A. Scanga, D.J. Laddy, L. Szeponik, P. Akeus, M. Quiding Jarbrink¨ and P.L. Lin, R.A. Seder, M. Roederer and J.L. Flynn. Univ. of W.C.I. Rodin. Univ. of Gothenburg, Sweden and Pittsburgh Sch. of Med., VRC, NIAID, NIH and AERAS. Sahlgrenska Acad., Univ. of Gothenburg, Sweden. P1619 139.4 SOCS1 antagonist-expressing recombinant P1605 138.15 Tumor infiltrating B cells co-localize with CD4 T BCG enhances anti-tuberculosis protection in a mouse effector cells within organized tertiary lymphoid structures to model. Y. Yasutomi. Natl. Inst. of Biomed. Innovation, Hlth. present antigen and educate the anti-tumor immune response and Nutrition, Japan. in human primary tumors. T.C. Bruno, A. Ruffin, A. Cillo, P1622 139.5 Subunit vaccine candidate with adjuvant D. Liu, S. Kunning, R.L. Ferris, D.A.A. Vignali and confers protection against clinical Mycobacterium avium in T.C. Bruno. Univ. of Pittsburgh Sch. of Med. and Univ. of wild type and immunocompromised mouse models. Pittsburgh Cancer Inst. S.E. Larsen, V.A. Reese, T. Pecor, G. Brewer, B. Berube, P1608 138.16 Attenuated Listeria vaccine for cancer S. Njikan, T. Parish, M. Henao-Tamayo, S.L. Baldwin and immunotherapy expands Vg2Vd2 T cells in rhesus monkeys R.N. Coler. Infectious Dis. Res. Inst. and Colorado State Univ. that retain their central memory phenotype and HMBPP P1620 139.6 Antigen-presenting cell targeted, adjuvant-free responsiveness. C.T. Morita, M.H.N. Al-Janabi, mucosal vaccine induces protection against pneumococcal G. Workalemahu and H. Wang. Carver Col. of Med., Univ. infection. S. Kumar, R. Sunagar and E.J. Gosselin. Albany of Iowa. Med. Col. P1609 138.17 Altered phenotypes of tumor-infiltrating B cells P1631 139.7 Immunity of a Klebsiella Pneumoniae vaccine fi in response to exhausted CD8+ T cells. C.A. Avalos, independent of antigen-speci c antibody. N. Iwanaga, C. Egelston, D. Simons, M.H. Lim, Y. Huang and I. Sandquist, K. Chen, E.B. Norton, J.R. Moreno and P.P. Lee. City of Hope Beckman Res. Inst. J.K. Kolls. Tulane Univ. Sch. of Med., Univ. of Pittsburgh P1610 138.18 Function of T follicular helper cells in anti-tumor Sch. of Med. and Univ. of Rochester Med. Ctr. immunity. R.I. Nurieva, Z. Liu, A. Gangadharan, S. Bieerkehazhi, Y-Z. Zhao, A. Alekseev and A. Sahoo. Univ. of Texas MD Anderson Cancer Ctr.

79 SATURDAY—POSTER SESSIONS

P1625 139.8 The development of Klebsiella pneumoniae P1635 139.18 Neuraminidase expressed on virus-like vaccine strategy via eliciting the serotype-independent particles is superior to inactivated split virus vaccine in immunity in the lung. N. Iwanaga, I. Sandquist, K. Chen, conferring cross protection via humoral and cellular E.B. Norton, J.R. Moreno and J.K. Kolls. Tulane Univ. Sch. immunity. K-H. Kim, Y-T. Lee, S. Park, Y-J. Jung, of Med., Univ. of Pittsburgh Sch. of Med. and Univ. of Y-J. Kim, Y. Lee and S-M. Kang. Georgia State Univ. Rochester Med. Ctr. P1624 139.20 Neuraminidase inhibition governs protection P1626 139.9 Protective role of TH17 cells in an FcgR efficacy of broadly neutralizing anti-influenza hemagglutinin targeting immunization strategy against the respiratory stem antibodies. I. Kosik, D. Angeletti, J.S. Gibbs, bacterial pathogen, Francisella tularensis. C. Bitsaktsis, M. Angel, K. Takeda, M. Kosikova, V. Nair, J. McCauley and K. Devenney. Seton Hall Univ. H.D. Hickman, H. Xie, C.C. Brooke and J.W. Yewdell. P1638 139.10 CD40-targeted S1 subunit vaccine protects NIAID, NIH, CBER, FDA and Univ. of Illinois, Urbana- against MERS-CoV and S1-associated pulmonary Champaign. immunopathology in transgenic human DPP4 mouse model. P1617 139.21 Development of broadly neutralizing A.M. Hashem, A. Algaissi, A. Agrawal, S. Al-amri, antibodies against influenza viruses from mice immunized A. Almasoud, N. Alharbi, B-H. Peng, X. Li and with monoglycosylated hemagglutinin. Y-A. Ko, Y-H. Yu, C-T. Tseng. King Abdulaziz Univ., Saudi Arabia, Univ. of Y-C. Tseng, C. Ma and K-I. Lin. Academia Sinica, Taiwan. Texas Med. Br., King Abdullah International Med. Res. Ctr., P1632 139.22 Natural gene-encoded affinity for cognate Saudi Arabia and Hlth. Canada, Canada. antigen facilitates vaccine-amplification of broadly P1628 139.11 Robust immune response and protection neutralizing antibodies against influenza virus. generated by a polyanhydride-based nanoparticle vaccine D. Lingwood. Ragon Inst. of MGH, MIT and Harvard. utilizing the RSV prefusion F protein and/or M protein. P1615 139.23 A computationally optimized broadly reactive L. Stephens, K.A. Ross, S.M. Hartwig, J.S. McLellan, antigen elicits broadly neutralizing antibodies against a B. Narasimhan, K.L. Legge and S.M. Varga. Univ. of Iowa, conserved influenza virus hemagglutinin B cell epitope. Iowa State Univ. and Univ. of Texas, Austin. G.A. Sautto, G.A. Kirchenbaum, J.W. Ecker, R.B. Abreu, P1629 139.12 Recombinant live attenuated influenza virus S.R. Pierce and T.M. Ross. Univ. of Georgia, Athens. expressing G protein fragment in a chimeric hemagglutinin P1633 139.24 Computer-optimized immunization strategy to molecule induces G-specific antibodies and confers protection boost highly cross-reactive antibodies to RSV. C.S. Anderson against respiratory syncytial virus. Y-J. Jung, Y-N. Lee, and T.J. Mariani. Univ. of Rochester Med. Ctr. K-H. Kim, Y.H. Lee, J. Lee, C. Kim and S-M. Kang. P1639 139.25 A knock-in mouse to test vaccines for the Georgia State Univ. and BEAMS Biotechnology, South Korea. broadly neutralizing influenza response. W. Li, T. Ota and P1627 139.13 Targeting CD40 enhances antibody- and CD8- D. Nemazee. Scripps Res. Inst. mediated protection against respiratory syncytial virus infection. A. Muralidharan, M. Russell, L. Larocque, 140. VIRUSES AND THE T CELL RESPONSE C. Gravel, . Li, W. Chen, T. Cyr, J.R. Lavoie, A. Farnsworth, M. Rosu-Myles, L. Wang and X. Li. Univ. Poster Session of Ottawa, Canada, Hlth. Canada, Natl. Inst. for Food and Drug SAT. 2:30 PM—EXHIBIT/POSTER HALL Control, China and Natl. Res. Council of Canada. fi + P1623 139.14 Non-complexed chitosan acts as an adjuvant P1678 140.1 ITK regulates antigen-speci c CD8 T cell- fl in an influenza A virus protein vaccine. A.T. Lampe, derived IL-10 production and modulates in uenza-induced E.J. Farris, M.D. Ballweg, A.K. Pannier and D.M. Brown. pulmonary immunopathology. W. Huang, S. Solouki and Univ. of Nebraska, Lincoln. A. August. Sch. of Vet. Med., Louisiana State Univ. and P1637 139.15 The complex of poly-g-glutamic acid and Col. of Vet. Med., Cornell Univ. fi aluminum salts ameliorates the reduced efficacy of the P1660 140.2 Single-cell transcriptomics identi es TOX as a influenza H1N1 vaccine in aged mice. J. Yang, J. Kim, key transcriptional regulator of stem-like CD8 T cells in chronic C. Kwak and H. Poo. Korea Res. Inst. of Bioscience and infection. T. Wu, C. Yao, H. Sun, N. Lacey, L. Gattinoni, ’ Biotechnology. D.B. McGavern, J.J. O Shea and P.L. Schwartzberg. NIAID, P1630 139.16 LTA1 is a safe, intranasal, enterotoxin-based NIH, NIAMS, NIH, NCI, NIH and NINDS, NIH. adjuvant that improves vaccine protection from influenza in P1671 140.3 Herpesvirus entry mediator promotes Th1 young, old, and B cell-depleted (mMT) mice. E.B. Norton, responses in the cornea during ocular HSV-1 infection. E. Valli, A.J. Harriett, M.K. Nowakowska, R.L. Baudier, S.J. Park, R. Riccio, S. Kopp and R. Longnecker. W.B. Provosty, L. Lawson and Y. Nakanishi. Tulane Univ. Feinberg Sch. of Med., Northwestern Univ. Sch. of Med. P1673 140.4 Cytotoxic CD4 T cells control host immunity P1621 139.17 Novel approaches for studying cell-mediated during viral persistence. N. Thiault, M. Husain, A. Chen, immune responses to influenza vaccination in humans. G. Verstichel, A. Larange, V. Shivagouda Patil, W. Cao, M. Mishina, Z. Ende, W.P. Mboko, D. Batra, P. Vijayanand, M. Kronenberg and H. Cheroutre. La Jolla C. Bohannon, P. Carney, J. Chang, P. Ranjan, A. Kumar, Inst. for Immunology. S. Amoah, S. Gangappa, S. Mittal, M. Sheth, J. Pohl, P1674 140.5 Monocytes and macrophages limit systemic J. Stevens and S. Sambhara. Ctr. for Dis. Control and infection and modulate the CD4 T cell response during Zika Prevention and Purdue Univ. virus infection in mice. Y-T. Wang, S. Hattakam, M.P. Young, J.A. Regla-Nava and S. Shresta. La Jolla Inst. for Immunology.

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P1675 140.6 PSGL-1 is a negative regulator of effector and P1677 140.15 CD4+ T cells promote humoral immunity and memory T cells. R. Tinoco and L.M. Bradley. Univ. of viral control during Zika virus infection. A. Elong Ngono, California, Irvine and Sanford Burnham Prebys Med. M.P. Young, M. Bunz, Z. Xu, S. Hattakam, E. Vizcarra, Discovery Inst. J.A. Regla-Nava, W.W. Tang, M. Yamabhai, J.S. Wen and P1666 140.7 The role of mTOR, TRAF1, and local antigen in S. Shresta. La Jolla Inst. for Immunology and Suranaree Univ. 4-1BB-dependent establishment of Trm in the lung. of Technol., Thailand. N.V. Batista, A.C. Zhou and T.H. Watts. Univ. of Toronto, P1661 140.16 WITHDRAWN Canada. P1664 140.17 Increased polyfunction in CD4 T cells from P1668 140.8 The pleiotropic effects of PTPN22 and its pro- persons with acute vs. remote shingles. W. Jin, M. Fang, autoimmune alternative allele on the anti-viral immune R. Vangipuram, I. Sayin, J. Golden, C. Cameron, response and T cell exhaustion. R.C. Orozco, M. Cameron, S. Tyring and D.H. Canaday. Case Western K. Marquardt, K.A. Mowen, I. Pratumchai, J.R. Teijaro Reserve Univ. and Univ. of Texas Hlth. Sci. Ctr. and L.A. Sherman. Scripps Res. Inst. P1669 140.18 Human Vg9Vd2-T cells exhibit potent antiviral P1662 140.9 Overexpression of CD6 and PD-1 identifies activity against EV71 infection. W. Tu. Univ. of Hong Kong, dysfunctional T cells during chronic SIV infection in rhesus Hong Kong. macaques. G. Enyindah-Asonye, A. Nwankwo, P1672 140.19 IL-21 deficient T follicular helper (TFH) cells M.A. Rahman, R. Hunegnaw, S. Helmold Hait, E-J. Ko, support B cell responses through interleukin-27 in patients S T. Hoang and M. Robert-Guroff. NCI, NIH and NIH. with chronic hepatitis B. A. khanam, A. Natrajan, L. Tang, A P1667 140.10 Generation of tissue-restricted CD4 effectors B. Poonia and S. Kottilil. Univ. of Maryland Sch. of Med. T (TFH and ThCTL) requires signals from local antigen and P1670 140.20 Evaluation of Th17 and Treg cells during infection during the effector phase. P. Devarajan, chronic Chikungunya infection. I.C. Guerra-Gomes, A.M. Vong, C.H. Castonguay, B.L. Bautista and J. Leite, A. Santana, B. Macedo,ˆ R. Fonseca, T. Keesen, S.L. Swain. Univ. of Massachusetts Med. Sch. V. Carregaro and J. Silva. Univ. of São Paulo, Brazil, Federal P1659 140.11 Molecular signatures of IL-10/IFN-g co- Univ. of Para´ıba, Brazil and Ribeirão Preto Fac. of Med., Univ. producing CD4 T cells during acute dengue virus infection. of São Paulo, Brazil. Y. Tian, G. Seumois, S. Herrera de la Mata, P1676 140.21 Human Tfh cells possess a unique metabolism S. Goonawardhana, A.D. de Silva, S. Premawansa, to allow them to differentiate and survive better upon HIV G. Premawansa, A. Wijewickrama, A. Grifoni, infection. S. Rane, W. Li, J. Lan, N. Shepherd, F. Syed, P. Vijayanand, B. Peters, D. Weiskopf and A. Sette.La J. Yang, Y. Xia and Q. Yu. Indiana Univ. Sch. of Med. Jolla Inst. for Allergy and Immunology, General Sir John P1679 140.22 Evaluation of HIV-specific T-cell responses in Kotelawala Defense Univ., Sri Lanka, Univ. of Colombo, Sri HIV-infected aging patients with controlled viremia on long- Lanka, North Colombo Teaching Hosp., Sri Lanka and NIAID, term antiretroviral therapy. N.E. Bradley, A. Wertheimer, NIH. S.A. Klotz and N. Ahmad. Univ. of Arizona. P1658 140.12 Microbial LPS enhances PD-1 therapy during chronic LCMV infection. P.A. Penaloza-MacMaster, Y. Wang, S. Eitzinger, M. Bhattacharyya and P. Penaloza- MacMaster. Northwestern Univ. P1663 140.13 Phospholipase A2 group IID is indispensable for coronavirus-specific humoral immune memory in middle- aged mice. J. Zheng and S. Perlman. Carver Col. of Med. Univ. of Iowa. P1665 140.14 Characterization of HLA-DP and DQ restricted Dengue virus-specific CD4+ T cell responses reveals lower magnitude responses associated with a differential pattern of immunodominance as compared to DR restricted responses. D. Weiskopf, A. Grifoni, M. Angelo, E. Moore, J. Sidney, E.J. Phillips, S.A. Mallal, A.D. de Silva, B. Peters and A. Sette. La Jolla Inst. for Immunology and Vanderbilt Univ. Sch. of Med.

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MAY 12

141. MAJOR SYMPOSIUM E: MECHANISMS OF 8:15 MHC class II conformers drive differential B cell ALLERGIC IMMUNITY activation. J.R. Drake. Albany Med. Col. (177.20) 8:30 Antigen processing and autophagy function in adjuvant- Major Symposium treated dendritic cell. K. Hashimoto, T. Ootomo, SUN. 8:00 AM—BALLROOM 20D A. Hasegawa, R. Kotera, D. Kobayashi and T. Nakayama. Chiba Inst. of Tech., Japan, CHAIRS: R.M. LOCKSLEY, J. VON MOLTKE Yamaguchi Univ., Japan, Chiba Inst. of Tech. 8:00 ILC2s in allergic immunity–center stage or bit players? Grad. Sch. of Engin., Japan and Chiba Univ. Grad. R.M. Locksley. Univ. of California, San Francisco. Sch. of Med., Japan. (177.26) 8:35 The missing piece: tuft cells and the intestinal type 2 8:45 An engineered vaccine encompassing an MHC class I immune response. J. von Moltke. Univ. of Washington. antigen presenting molecule induces self-reacting 9:10 Lung crosstalk to residential immune cells. X. Sun. CTL in a setting of profound tolerance. L.R. Pease, Univ. of California, San Diego. C.A. Parks, D. Kranz and M. Barry. Mayo Clin., 9:45 Epithelial cell remodeling in the respiratory mucosa: Columbia Univ. Med. Ctr. and Univ. of Illinois, from form to function. N.A. Barrett. Brigham and Urbana-Champaign. (177.30) Women’s Hosp. 9:00 High GILT expression and an active and intact MHC 10:20 The neuroimmune basis of chronic itch. B.S. Kim. class II antigen presentation pathway are associated Washington Univ. Sch. of Med. in St. Louis. with improved survival in melanoma. K. Hastings, 10:55 Control of dendritic cell migration in response to L. Meador, H. Menon, Y-K. Lu, J. Brill, H. Cui, allergens. C.L. Sokol. Massachusetts General Hosp. D.J. Roe, D.J. DiCaudo and K.H. Buetow. Univ. of Arizona, Arizona State Univ. and Mayo Clin. 142. MAJOR SYMPOSIUM F: FUNCTIONAL (177.32) PLASTICITY OF INNATE AND ADAPTIVE 9:15 Splenic CD169+ marginal zone macrophages directly cross-prime CD8+ T cells in vivo using a vacuolar IMMUNE CELLS processing pathway. P.M. Van Endert, F. Mauvais, Major Symposium Y. Hamel, J. Diana and M. Garfa. Institut Necker- Enfants Malades, France and INSERM UMS24, SUN. 8:00 AM—BALLROOM 20BC France. (177.22) CHAIRS: A.W. GOLDRATH, J.A. HAMERMAN 9:30 Epitope mapping of Mycobacterium tuberculosis proteins using a non-human primate model of 8:00 Reinforcing memory T cell states and fates. A.W. infection. N.L. Grant, A.J. Balgeman, A.L. Ellis, Goldrath. Univ. of California, San Diego. S.L. O’Connor, C.A. Scanga and J.L. Flynn. 8:35 Monocyte differentiation during inflammation. J.A. Univ. of Pittsburgh Grad. Sch. of Publ. Hlth., Univ. Hamerman. Benaroya Res. Inst. of Wisconsin-Madison and Univ. of Pittsburgh Sch. of 9:10 Metabolic plasticity during hematopoietic development Med. (177.29) and B cell responses. D. Bhattacharya. Univ. of Arizona. 9:45 Dynamic T-bet expression in CD4 T cell subset. J. Zhu. 144. BASIC AUTOIMMUNITY: B CELLS NIAID, NIH. Block Symposium 10:20 Tumor immunity and pancreatic cancer. D.G. DeNardo. — Washington Univ. in St. Louis. SUN. 8:00 AM ROOM 30AB 10:55 Impact of genetic polymorphisms on human immune CHAIRS: J. MOUNTZ, H. SCHJERVEN cell gene expression. P. Vijayanand. La Jolla Inst. for fi Immunology. 8:00 Type I IFN and IL-4R de ne B cell checkpoint defects in systemic lupus erythematosus. J.D. Mountz, S. Liu, Q. Wu, P. Yang, W.Alex Essman, O.A. Ojo, B. Luo, 143. ANTIGEN PROCESS AND PRESENTATION I M. Gao, J.Y. Chen, I. Sanz, W.W. Chatham and Block Symposium H-C. Hsu. Univ. of Alabama at Birmingham and Emory Univ. (179.5) SUN. 8:00 AM—ROOM 26AB 8:15 Divergent roles for TLR7 and TLR9 in modulating the CHAIRS: S. CASCIO, L. PEASE NFkB pathway in B cells. K.K. Nundel, S. Moses, J.H. Shim and A. Marshak-Rothstein. Univ. of 8:00 Identification of specific T lymphocytes against to an Massachusetts Med. Sch. (179.12) IFNg inducible lysosomal thiol reductase-dependent, class II MHC-associated epitope in GILT -/- mice. X. He, H. Dai, E. Reyes-Vargas and P.E. Jensen. Univ. of Utah Sch. of Med. (177.19)

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8:30 Ikaros mutations can bypass the requirement for 9:00 The role of aquaporin-4 in T cell activation. M. Nicosia, second co-stimulatory signal and lead to break of A.M. Beavers, G.W. Farr, P.R. McGuirk, B-cell tolerance. H. Schjerven, P.D. Rodriguez, M. Pelletier and A. Valujskikh. Cleveland Clin. W. Howell, J. Vestbostad, S. Frietze and and Aeromics LLC. (186.8) H. Schjerven. Univ. of California, San Francisco, 9:15 Lymphopenia and bone marrow T cell sequestration Univ. of Vermont and KG Jebsen Centre for B Cell accompanying stroke are mediated by T cell S1P1 Malignancies, Oslo Univ. Hosp., Norway. (179.16) loss. D.S. Wilkinson, C. Dechant, 8:45 Ikaros regulates chromatin landscape in mature B cells, P. Chongsathidkiet, H. Wang, H. Kemeny, and is critical for B cell tolerance. P.D. Rodriguez, D. Laskowitz and P. Fecci. Duke Univ. Med. Ctr. W. Howell, E. Amiel, S. Frietze and H. Schjerven. (186.15) Univ. of Vermont and Univ. of California, San 9:30 Using single-cell RNA-seq to lineage trace effector to Francisco. (179.15) memory transitions in CD4+ T cells during malaria. 9:00 Novel role of T cells to induce development of S.F.M. Soon, J. Engel, J. Lee, K. James, proliferative plasmablasts in systemic lupus T. Lonnberg, V. Svensson, S. Teichmann and erythematous. O.A. Ojo, S. Liu, Q. Wu, A. Haque. QIMR Berghofer Med. Res. Inst., P.A. Yang, D.K. Crossman, W. Chatham, Australia, Wellcome Trust Sanger Inst., Univ. of H-C. Hsu and J.D. Mountz. Univ. of Alabama, Turku, Finland and California Inst. of Technol. (186.1) Birmingham and Univ. of Alabama Sch. of Med. 9:45 Activation-dependent posttranscriptional regulation of (179.10) CD40L is required for an optimal germinal center 9:15 The contribution of anergic B cells to protective response. B. Narayanan, D. Prado De Maio, immunity. A. Agazio, K. Shotts-Schroeder, K. Voskoboynik, J. La Porta, P. Xie and M.L. Santiago, R.A. Pelanda and R.M. Torres. L.R. Covey. Rutgers Univ. (186.16) S Univ. of Colorado Anschutz Med. Campus. (179.14) U + 9:30 Characterization of CD11c B-cells from human blood. 146. ADVANCES IN THERAPEUTIC APPROACHES N S.F. Calbo, M. Demeules, C. Derambure, G. Riou, FOR NEUROLOIMMUNOLOGIC DISEASES M. Vaillant, O. Boyer, P. Joly and M-L. Golinski. Inserm U1234, France. (179.6) Block Symposium 9:45 Age-associated B cells in early drug-naive rheumatoid SUN. 8:00 AM—ROOM 33ABC arthritis patients. G.V. Vidal-Pedrola, J. Cameron, A. Pratt, A. Mellor, D. Scheel-Toellner, J. Isaacs CHAIRS: N. KARANDIKAR, F. QUINTANA and A. Anderson. Newcastle Univ., United Kingdom 8:00 Efficacies of anti-CD20 antibody and atacicept are and Univ. of Birmingham, United Kingdom. (179.9) differentially impacted by B cell maturation antigen in neuro-autoimmunity. G. Kumar, R.M. Ko and 145. MOLECULAR CONTROL OF CD4+ T CELL LIFE R.C. Axtell. Oklahoma Med. Res. Fndn. (193.9) CYCLE: DEVELOPMENT, ACTIVATION, 8:15 Human neural stem cells induce central nervous system EFFECTOR, AND MEMORY specific regulatory T cells from the ex Treg pool and promote repair in models of multiple sclerosis. Block Symposium S.A. Greilach, L.L. McIntyre, J. Hasselmann, SUN. 8:00 AM—ROOM 31ABC S. Othy, Q. Nguyen, K. Kessenbrock, M.D. Cahalan, M. Blurton-Jones, T. Lane and HAIRS B. ZHOU, D. TANTIN C : C.M. Walsh. Univ. of California, Irvine and Univ. of 8:00 Characterization and transcriptional profiling of tissue- Utah, Sch. of Med. (193.10) resident memory CD4+ T cells. Q.P. Nguyen, 8:30 Neuroantigen-specific regulatory CD8+ T cell T. Deng and A.W. Goldrath. Univ. of California, responses as a therapy for relapsing autoimmune San Diego. (186.2) demyelinating disease. A.A. Brate, F.R. Itani, 8:15 NF-kB/mTOR/MYC axis drives PRMT5 protein L.L. Pewe, J.T. Harty and N.J. Karandikar. induction after T cell activation. S. Sengupta, Carver Col. of Med. Univ. of Iowa. (193.11) L. Webb, J. Narvaez-Miranda, S. Amici, G. Nagy 8:45 IL-22 and Reg3g overexpression affects experimental and M. Guerau-De-Arellano. Col. of Med., The Ohio autoimmune encephalomyelitis severity. A. Eken, State Univ. and The Ohio State Univ. (186.9) M.F. Yetkin, F.Z. Okus, M. Cakir, M.O. Karayigit, 8:30 Transcription coactivator OCA-B mediates interactions S. Erdem, Y. Haliloglu, M. Oukka, H. Donmez between target loci in T cells and is sufficient to Altuntas, M. Mirza and H. Canatan. Erciyes Univ., promote CD4 memory in vivo. D.R. Tantin, Cumhuriyet Univ. and Univ. of Washington Sch. of K. Zhao, M.A. Williams, J.S. Hale, B. Lai, G. Ren Med. (193.12) and H. Kim. Univ. of Utah and NHLBI, NIH. (186.3) 9:00 The aryl hydrocarbon receptor as a regulator of CNS 8:45 Identification of distinct highly pathogenic allergen- autoimmunity. J. Kenison-White, A. Jhaveri, specific T cells in common allergy and asthma. S. Tezza, D. Nowakowska, D. Sherr and G. Seumois, C. Ramirez Suastegui, F.J. Quintana. Boston Univ. Sch. of Med., B.J. Shmiedel, S. Liang, V. Shulten, B. Panwar, AnTolRx, Inc. and Brigham and Women’s Hosp., A. Madrigal, A. Sette, B. Peters and P. Vijayanand. Harvard Med. Sch. (193.13) La Jolla Inst. for Immunology. (186.6)

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9:15 Myelin basic protein specific TCR-engineered 9:45 Type I interferon suppresses tumor growth through regulatory T cells from multiple sclerosis patients activating the STAT3-granzyme B pathway in are suppressive to MBP-specific T effector cells. tumor-infiltrating cytotoxic T lymphocytes. C. Lu, A. de Paula Alves Sousa, Y.C. Kim, S. Jacobson J.D. Klement, M.L. Ibrahim, P.S. Redd, G. Zhou and D.W. Scott. Uniformed Serv. Univ. of the Hlth. and K. Liu. Augusta Univ. (194.8) Sci. and NINDS, NIH. (193.14) 9:30 Deficiency in B cell maturation antigen reveals gender 148. HOW VIRUSES OVERRIDE THE differences in experimental autoimmune IMMUNE SYSTEM encephalomyelitis. G. Kumar, R.M. Ko and R.C. Axtell. Oklahoma Med. Res. Fndn. (193.15) Block Symposium 9:45 Photobiomodulation therapy regulates the production of SUN. 8:00 AM—ROOM 25ABC IL-10 and IFN-g by peripheral blood mononuclear cells and CD4+ T cells isolated from subjects with CHAIRS: J. TING, M. RICHER multiple sclerosis. M. Tolentino, C.C. Cho and 8:00 Alveolar macrophage dysfunction and increased PD-1 J-A. Lyons. Univ. of Wisconsin, Milwaukee. (193.16) expression during chronic SIV infection of rhesus macaques. R. Hunegnaw, Z. Mushtaq, 147. NOVEL TUMOR TARGETS/THERAPIES G. Enyindah-Asonye, T. Hoang and M. Robert- Block Symposium Guroff. NIH. (197.1) 8:15 HIV-induced production of CCL2 may promote rapid SUN. 8:00 AM—ROOM 29ABCD seeding of the latent HIV reservoir. T.A. Packard, E. Herzig, X. Luo, J.H. Egedal, Z.W. Grimmett, CHAIRS: M. KROGSGAARD, K. PAYNE K.J. Hasenkrug, N. Roan and W.C. Greene. 8:00 JAML-CAR—a mechanism of T cell antitumor immunity. Gladstone Inst. of Virology and Immunology, J.M. McGraw, D. Witherden and W.L. Havran. Aarhus Univ., NIAID, NIH and Univ. of California, Scripps Res. Inst. (194.1) San Francisco. (197.2) 8:15 Butyrophilin 3A1 is a dynamic T cell regulator in ovarian 8:30 Stochastic HIV gene expression is a novel mechanism cancer. K.K. Payne, R. Chaurio Gonzalez, J. Perez for HIV persistence. R.A. Matus Nicodemos, Sanz, C.M. Anadon Galindo, S. Biswas, J.A. Mine, D. Douek and R. Koup. NIAID, NIH. (197.3) A. Perales-Puchalt, E. Tsiganov, T.L. Costich, 8:45 NLRX1 facilitates HIV-1 infection of CD4 T cells by C.M. Harro, A.K. Marrs, J. Lajoie, K-P. Li, promoting oxidative phosphorylation. H. Guo, M. Ophir, U. Eskiocak, M. Schmidt, Q. Wang, L. Wang, E. Rampanelli, X. Chen, D.I. Gabrilovich and J.R. Conejo-Garcia. Moffitt S. Chanda, L. Su and J.P. Ting. Univ. of North Cancer Ctr. and Res. Inst., Wistar Inst. and Carolina, Chapel Hill, Univ. of Amsterdam, The Compass Therapeutics. (194.2) Netherlands and Sanford Burnham Prebys Med. 8:30 Combination of anti-CD40 and anti-PD1 revert M2 Discovery Inst. (197.4) polarization to limit tumor growth in a genetically 9:00 Sphingosine kinase 2 mediates LCMV-induced CD4+ engineered bladder cancer mouse model. T cell suppression and instigates viral persistence G. Verdeil, M. Leblond, C. Imbratta and while preventing immunopathology. C.J. Studstill, D.E. Speiser. Univ. of Lausanne, Switzerland. C.J. Pritzl, Y-J. Seo, D.Y. Kim, C.Z. Xia, (194.3) J.J. Wolf, M. Vijayan and B. Hahm. Univ. of 8:45 Inhibition of NK cell-MHCI interactions disrupts immune Missouri, Columbia and Chung-Ang Univ. (197.5) homeostasis by activation of the IFNg/IL15 axis 9:15 A Brazilian Zika virus isolate suppresses type I resulting in augmentation of anti-tumor immunity. interferon to establish a sustained infection in A.K. Panda and E.M. Shevach. NIAID, NIH. (194.4) immunocompetent mice. R.D. Pardy and 9:00 T cell intrinsic mechanisms of resistance to PD-1 M.J. Richer. McGill Univ., Canada. (197.6) checkpoint blockade. M. Krogsgaard, D. Moogk, 9:30 Impaired T cell activation resulting from IL-33 induced L. Wang, K. Li, Z. Yuan, J. Weber, I. Osman and myeloid derived suppressor cells and IL-10 secreting C. Zhu. New York Univ. Sch. of Med., Georgia Inst. of Tregs is a major determinant of susceptibility to HSV1 Tech., NYU Med. Ctr. and New York Univ. Med. Ctr. infection of the central nervous system. R. Chandran, (194.5) S. Mendonca and EM. Cantin. City of Hope 9:15 Virus-specific memory T cells populate tumors and can Beckman Res. Inst. (197.7) be repurposed as a tumor immunotherapy. 9:45 Vaccinia virus E5 is a dominant inhibitor of the cytosolic P. Rosato, S. Wijeyesinghe, M. Stolley, DNA sensor cGAS. N. Yang, Y. Wang, S. Shuman C. Nelson, R.L. Davis, L.S. Manlove, and L. Deng. Memorial Sloan Kettering Cancer Ctr. C.A. Pennell, B.R. Blazar, C.C. Chen, (197.8) M.A. Geller, V. Vezys and D. Masopust. Univ. of Minnesota. (194.6) - 9:30 Low-dose neoadjuvant chemotherapy dominates Ki67 Sunday is the last day to visit the Exhibit Hall. quiescent tumor dormancy for an effective Open 9:30 AM – 4:30 PM. immunotherapy of breast cancer. H. Aqbi, C. Coleman, M. Idowu and M. Manjili. Virginia Commonwealth Univ. (194.7)

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149. SECRETS FOR A SUCCESSFUL 152. NIH GRANTS WORKSHOP: DEMYSTIFYING THE POSTDOCTORAL FELLOWSHIP GRANT APPLICATION SUBMISSION, REVIEW, Career Development Session AND FUNDING PROCESSES Career Development Session SUN. 9:00 AM—ROOM 32AB SUN. 10:15 AM—ROOM 30AB CHAIR: M.T. LITZINGER HAIR T. MCINTYRE A postdoctoral fellowship is the time to develop research C : skills you will need to succeed as an independent scientist. It is, This workshop will provide participants with an overview of NIH however, just as important to realize that you need to prepare for grant submission, assignment, review, and funding opportunities. a career path at the same time. This session will highlight ways of Emphasis will be given to identification of the most appropriate getting the most out of your postdoctoral fellowship, relating funding agencies and mechanisms available through NIH, how to successfully with your mentor, and understanding how to use make an application “reviewer friendly,” and other strategies that the resources available to you to ensure that your training contributetoapplicationsthatsucceedinobtainingresearchfunding. prepares you adequately for a seamless transition into the Theworkshopwillalsoprovideinformationonhowtounderstandthe next phase of your career. peer reviewsystem, which isessential tocompeting successfully for 9:00 Introduction. M.T. Litzinger. AAI. funding, with a focus on recent changes to the review process. NIH 9:05 Secrets for a Successful Postdoctoral Fellowship. review and program staff will provide a broad array of expertise and R. Wheeler. Scripps Res. Inst. encourage questions from seminar participants. This workshop is open to anyone interested in learning more about preparing an NIH grant application and obtaining NIH funding. Trainees and 150. NIH GRANT REVIEW AND FUNDING independent investigators are welcome. S INFORMATION ROOM PANELISTS: U Career Development Session • T. McIntyre. CSR, NIH. N SUN. 9:30 AM (ALL DAY)—ROOM 21 • D. Hodge. CSR, NIH. • J. Breen. NIAID, NIH. NIH program and review staff will be available for individual conversations and consultations. Staff members will answer 153. THE AMERICAN SOCIETY FOR questions about the scientific review process, grant/fellowship opportunities, and NIH Institute specific interests. Consultations HISTOCOMPATIBILITY AND will be available on a drop-in basis. No appointments are IMMUNOGENETICS (ASHI): HLA AND necessary. HUMAN IMMUNITY Guest Society Symposium 151. INTERNATIONAL OPPORTUNITIES IN SCIENCE SUN. 10:15 AM—ROOM 31ABC Career Development Session CHAIRS: W. HILDEBRAND, E. REED SUN. 10:15 AM—ROOM 32AB 10:15 Role of HLA in allergy. B. Peters. La Jolla Inst. for CHAIR: W.F. PICKL Allergy and Immunology. Working as a scientist outside of the U.S. requires curiosity, 10:35 HLA and the mutational burden of tumors. H. Carter. adaptability, and open-mindedness, which are valuable qualities Univ. of California, San Diego. important for success in any career. Given the international reach 10:55 Monitoring antibodies to HLA in organ transplantation. of science, this new session will help immunologists learn about E. Reed. Univ. of California, Los Angeles. opportunities to gain professional experience beyond the U.S. 11:15 Co-evolution of HLA and HIV-1. T. Allen. Harvard Univ. This panel features scientists employed at academic or research 11:35 T cell responses mediated by human MR1. M. Hariff. institutions around the globe. Panelists will discuss the Oregon Hlth. & Sci. Univ. postdoctoral fellowship and grant application process, the benefits of international training and employment, and the 154. CANADIAN SOCIETY FOR IMMUNOLOGY (CSI) challenges in finding science-related jobs outside of the U.S. SYMPOSIUM: EVOLVING MECHANISMS OF This session is open to anyone. DISEASE TOLERANCE IN INFECTION PANELISTS: AND IMMUNITY • M. Collin. Lund Univ., Sweden. Guest Society Symposium • T. Kamradt. Univ. Hosp. Jena, Germany. SUN. 10:15 AM—ROOM 25ABC • S. Koyasu. RIKEN Ctr. for Integrative Med. Sci., Japan. CHAIRS: I. KING, L. OSBORNE • H. Ostergaard. Univ. of Alberta, Canada. 10:15 Innate immune mechanisms of disease tolerance to • E.-C. Shin. Korea Adv. Inst. of Sci. and Technol., intestinal helminth infection. I. King. McGill Univ. Korea. 10:45 Disease tolerance: a missing link in immunity to influenza virus infection. M. Divangahi. McGill Univ. 11:15 Using mouse diversity as a way to probe disease tolerance to malaria infections. D. Schneider. Stanford Univ.

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11:45 Dissecting the contributions of host resistance and 10:30 Gut IgA abundance in adult life can protect from DSS tolerance in the outcome of Mycobacterium colitis even if maternal IgA received in early life is tuberculosis infection. A. Olive. Michigan State Univ. inadequate. S. Gupta, S. Basu, V. Bal, S. Rath and A. George. Natl. Inst. of Immunology, India and Weill 155. INFLAMMATORY AND AUTOIMMUNE DISEASE Cornell Med. (192.6) 10:45 Enhancement of gut barrier function by microbial Block Symposium metabolite, urolithin A via AhR-Nrf2 dependent SUN. 10:15 AM—ROOM 30CDE pathways in IBD. V.R. Jala, R. Singh, S. Chandrashekarappa, S.R. Bodduluri, CHAIRS: R. TIROUVANZIAM, A. JOHNSON B.V. Becca, B. Hegde, N. Kotla, A.A. Hiwale, 10:15 Galectin-3 promotes non-canonical inflammasome T. Saiyed, P. Patel, M. Vijay-Kumar, M. Langille, activation through binding to glycans on LPS G.M. Douglas, G. Dryden, X. Cheng, E. Rouchka, intracellularly. T-H. Lo, H-L. Chen, H-Y. Chen and S.J. Waigel, H. Alatassi, H-G. Zhang, B. Haribabu F-T. Liu. Academia Sinica, Taiwan. (183.1) and P.K. Vemula. Univ. of Louisville, Inst. for Stem 10:30 Leukotriene B4 is required for inflammasome activation. Cell Biol. and Regenerative Med., India, Univ. of A. Salina, S. Brandt, A.I. Medeiros and Louisville., Centre for Cellular and Molec. H. Serezani. Vanderbilt Univ. Med. Ctr. and Sao Platforms, India, The Univ. of Toledo Col. of Med. Paulo State Univ. (183.17) and Life Sci. and Dalhousie Univ., Canada. (192.4) 10:45 Roles of Toll-like receptors in regulating fibroblastic 11:00 Lingo3 interacts with TFF2 to control mucosal integrity, reticular cell pathobiology during sepsis. M. Deng, type 1 inflammation, and colitic tissue repair. K. Zullo, Y. Li, T. Chen, K. Chen and T.R. Billiar. Univ. of Y. Ji, Y. Wei, K. Herbine, N. Maloney, R. Cohen, Pittsburgh. (183.5) C. Pastore, M. Somsouk, S. Srivatsa, L-Y. Hung, 11:00 PGD2/DP1 signaling deficiency ameliorates M. Kohanski, N. Cohen and D. Herbert. Univ. of experimental autoimmune encephalitis. J. Zheng Pennsylvania Sch. of Vet. Med., Univ. of California, and S. Perlman. Carver Col. of Med., Univ. of San Francisco and Perelman Sch. of Med., Univ. of Iowa. (183.7) Pennsylvania. (192.8) 11:15 Prevention of erythrocyte fragility and anemia induced 11:15 Maternal immunoglobulin A protects against the by extracellular histones. F. Kordbacheh, development of necrotizing enterocolitis in preterm C.H. O’Meara, L.A. Coupland, P.M. Lelliott and infants. T.W. Hand, K. Gopalakrishna, C.R. Parish. The John Curtin Sch. of Med. Res., B.R. Macadangdang, M. Rogers, J.T. Tometich, Australian Natl. Univ., Australia. (183.3) J. Ji, B.A. Firek, R. Baker, A.H.P. Burr, C. Ma, 11:30 Single-step purification of sputum extracellular vesicles M. Good and M. Morowitz. Univ. of Pittsburgh, from cystic fibrosis patients using aF4-MALS. David Geffen Sch. of Med., UCLA, Univ. of B. Dobosh, S. Liu, M. Chen and Pittsburgh Sch. of Med., Sch. of Med., Tsinghua R.M. Tirouvanziam. Emory Univ. and Wyatt Tech. Univ., China and Washington Univ., St. Louis. (183.15) (192.10) 11:45 Glycolytic regulation of neuroinflammatory response: 11:30 Indole-3-carbinol prevents murine colitis development role of monocarboxylate transporter 4. S. Giri, via an IL-22-dependent mechanism that regulates J. Singh, H. Suhail, A. Kumar and R. Rattan. anti-microbial peptides and mucus production. Henry Ford Hlth. Sys. and Wayne State Univ. Sch. P.B. Busbee, H. Alrafas, N. Dopkins, of Med. (183.12) M. Nagarkatti and P.S. Nagarkatti. Univ. of South 12:00 Brain-Thymus communication is a novel Carolina Sch. of Med. (192.12) immunosuppressive feature of neurological insults. 11:45 Gut antibody deficiency in CD19-/- mice results in a K. Ayasoufi, C.K. Pfaller, R.H. Khadka, F. Jin and spontaneous Celiac-like sprue. A.D. Mohammed A.J. Johnson. Mayo Clin., Mayo Clin. Grad. Sch. of and J.L. Kubinak. Univ. of South Carolina Sch. of Biomed. Sci. and Mayo Clin., Rochester, Minnesota. Med. (192.11) (183.19) 12:00 Osteopontin promotes survival of intestinal intraepithelial lymphocytes and protects against 156. IMMUNITY DURING INTESTINAL DISEASE colitis. A. Nazmi, M.J. Greer, K.L. Hoek, M.B. Piazuelo, H-H. Weitkamp and D. Olivares- Block Symposium Villagomez. Vanderbilt Univ. Med. Ctr. (192.2)

SUN. 10:15 AM—ROOM 33ABC

CHAIRS: J. KUBINAK, D. OLIVARES-VILLAGOMEZ 10:15 Ulcerative colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts. H. Yang, H.C. Mirsepasi- Lauridsen, C. Struve, J.M. Allaire, E. Bosman, A. Sivignon, W. Vogl, C. Ma, G. Reid, X. Li, A.M. Petersen, K. Jacobson, S. Gouin, N. Barnich, H. Yu, K.A. Krogfelt and B.A. Vallance. Univ. of British Columbia, Canada, Statens Serum Inst., Denmark, Clermont Univ., France., Lerner Res. Inst., Hvidovre https://www.aai.org/About/Committees/CSOW/Career-Advisory-Board Univ.Hosp.,DenmarkandLUNAMUniv.,France.(192.3)

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157. AAI VANGUARD LECTURE Committee-Sponsored Session Sponsored by the AAI Minority Affairs Committee

SUN. 11:15 AM—ROOM 26AB

CHAIR: R.J. BINDER Since 2003, the AAI meeting has featured a scientific lecture presented by an AAI member who is an underrepresented minority investigator noted for scientific achievement and exemplary career success. 11:15 Adenosine receptor axis in blood brain barrier (BBB) permeability regulation. M.S. Bynoe. Cornell Univ.

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158. AAI PRESIDENT’S SYMPOSIUM AND 161. THE SOCIETY FOR GLYCOBIOLOGY (SFG) PRESENTATION OF EXCELLENCE IN SYMPOSIUM: HARNESS THE GLYCOME MENTORING AWARD IN IMMUNITY President’s Program Guest Society Symposium

SUN. 12:30 PM—BALLROOM 20BCD SUN. 12:30 PM—ROOM 30AB

CHAIR: J.L. FLYNN CHAIRS: G. ALTER, J. PAULSON PRESENTATION OF EXCELLENCE IN MENTORING AWARD 12:30 Sweet revenge – bacterial immune evasion through specific antibody glycan hydrolysis. M. Collin. Lund The AAI Excellence in Mentoring Award recognizes Univ., Sweden. exemplary career contributions to a future generation of scientists. 1:00 Adaptive immune responses induced by HIV envelope 12:30 Introduction. J.L. Flynn, Univ. of Pittsburgh Sch. of glycoprotein. V. Avci. Univ. of Georgia. Med., AAI President; and M.L. Shinohara, Duke 1:30 B cell-independent glycan programming of IgG function. Univ. Sch. of Med. B. Cobb. Case Western Reserve Univ. 2:00 Mucin glycans in the regulation of microbial virulence. K. Recipient: H. Cantor. Dana-Farber Cancer Inst., Harvard Med. Ribbeck. Massachusetts Inst. of Technol. Sch. PRESIDENT’S SYMPOSIUM: INTERACTIONS OF 162. THE OBESITY SOCIETY (TOS) SYMPOSIUM: PATHOGENS WITH THE IMMUNE SYSTEM ROLES OF IMMUNE CELLS IN 12:50 Tuberculosis: exceptions to every rule. P. Lin. OBESITY-ASSOCIATED INFLAMMATION ’ Children s Hosp. of Pittsburgh. Guest Society Symposium 1:15 Immunity in the immunocompromised host. K.A. Norris. Univ. of Georgia. SUN. 12:30 PM—ROOM 32AB 1:40 Intravenous vaccination as an approach for inducing CHAIRS: G.V. DENIS, V. PERISSI protective tissue resident T cell responses against tuberculosis and malaria. R. Seder. NIAID, NIH. 12:30 Immune dysregulation increasing risk of comorbidities 2:05 Transcriptional regulation of the inflammatory response. in childhood obesity. A.E. Hogan. Natl. Children’s V. Lazarevic. NCI, NIH. Res. Ctr., Ireland. 1:00 The cGAS-cGAMP-STING pathway: a molecular link 160. SOCIETY FOR NATURAL IMMUNITY (SNI) between immunity and metabolism. F. Liu. Univ. of SYMPOSIUM: NOVEL INSIGHTS INTO Texas Hlth. Sci. Ctr, San Antonio. 1:30 Chronic inflammation in progression of triple negative NATURAL KILLER CELL METABOLISM breast cancer in disparate populations. N. Ko. Boston AND FUNCTION Med. Ctr. Guest Society Symposium 2:00 BET bromodomain targeting suppresses the PD-1/PD- 1L pathway in triple-negative breast cancer and elicits — SUN. 12:30 PM ROOM 26AB anti-tumor immune response. G. Andrieu. Inst. CHAIRS: A. CERWENKA, T. FEHNIGER Necker Enfants Malades, France. 12:30 Metabolic requirements for NK cell antiviral effector functions. M.A. Cooper. Washington Univ. Sch. of 163. BASIC AUTOIMMUNITY: ANTIGENS AND Med. INNATE IMMUNITY 1:00 mTOR-dependent NK cell proliferation and subset Block Symposium plasticity maintains global repertoire stability during — homeostasis. K.-J. Malmberg. Oslo Univ. Hosp., SUN. 12:30 PM ROOM 25ABC Norway. CHAIRS: R. BUCALA, N. YAN 1:30 Inhibition of the Hif1a-mediated metabolic checkpoint unleashes potent NK cell anti-tumor immunity. J. Ni. 12:30 Antigen dose affects disease kinetics in a murine model of Heidelberg Univ., Germany. demyelinating disease. C.A.M. Gavile, A. Alexander, 2:00 Natural Killer cells switch their killing mechanism during F. Adler and B.D. Evavold. Univ. of Utah. (180.7) serial killing of tumor cells. C. Watzl. Leibniz Res. Ctr., 12:45 Increased immune surveillance of neuron-restricted Germany. antigen during demyelination leads to axon loss perpetrated by CD8+ T cells. B.D.S. Clarkson, E.M. Grund, K. Mirchia, M.M. Standiford and C.L. Howe. Mayo Clin. and Mayo Grad. Sch. (180.1)

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1:00 Small numbers of T cells specific to different myelin- 2:00 Transcriptomic analysis of human IL-7 receptor alpha low antigens cooperate to induce autoimmunity in a and high effector memory CD8+ T cells reveals an age- murine model of multiple sclerosis. R.R. Robinson, associated signature linked to influenza vaccine E.M. Rojano and T. Forsthuber. Univ. of Texas, San response in older adults. H-J. Park, M.S. Shin, Antonio. (180.3) M. Kim, J. Bilsborrow, S. Mohanty, 1:15 Pancreatic beta cells are constantly interacting with the R.R. Montgomery, A. Shaw, S. Yoo and I. Kang. immune system. X. Wan, B. Zinselmeyer, Yale Univ. Sch. of Med. and Cedars-Sinai Med. Ctr. P. Zakharov, A.N. Vomund, C.F. Lichti and (181.22) E.R. Unanue. Washington Univ. Sch. of Med., St. 2:15 IL-2 signals program the fate of exhausted CD8 T cells. Louis. (180.5) V. Kalia, H. Xiao, Y. Yuzefpolskiy and S. Sarkar. 1:30 Natural killer cell re-modeling of the extra-cellular matrix Univ. of Washington and Seattle Children’s Res. Inst. by the degradation of hyaluronan: potential role in (181.24) type 1 diabetes. B.E. Fuchs, V. Wall, I. Kang, G. Workman, S. Evanko, T. Wight and 165. INNATE CELLS IN ANTI-PATHOGEN AND S.A. Long. Benaroya Res. Inst. (180.11) CYTOKINE RESPONSES 1:45 MIF and MIF2 have distinct but synergistic roles in CIA pathogenesis. E.H. Doherty, P.V. Tilstam and Block Symposium R. Bucala. Yale Univ. Sch. of Med. (180.13) SUN. 12:30 PM—ROOM 30CDE 2:00 Pulmonary involvement in a mouse model of Sjogren¨ ’s syndrome induced by activation of the STING CHAIRS: M. NAGARKATTI, J. YEN pathway. J.A. Papinska, G. Gmyrek, 12:30 Functional Nrf2 restrains inflammatory and R.S. Srinivasan, U. Deshmukh and H. Bagavant. transcriptional phenotypes in microglia and its S Oklahoma Med. Res. Fndn. (180.16) deficiency recapitulates the aging phenotype. U 2:15 STING-mediated chronic activation of ER stress I-C.I. Yu, H.C. Paraiso, P-C. Kuo, B.A. Scofield, N through disrupting calcium homeostasis primes R.D. Sweazey, F-L. Chang and J-H. Yen. Indiana T cells for cell death. J. Wu and N. Yan. Univ. of Univ. Sch. of Med. (185.17) Texas Southwestern Med. Ctr. (180.15) 12:45 MiR-146a is a negative regulator of IL-33-stimulated mouse mast cells. S.A. Kee, M.T. Taruselli, 164. CYTOKINE AND CHEMOKINE CONTROL J.J. Ryan and A. Abdul Qayum. Virginia OF IMMUNITY Commonwealth Univ. (185.5) 1:00 Cannabinoid receptor 1 blockade attenuates obesity Block Symposium and adipose tissue type 1 inflammation through SUN. 12:30 PM—ROOM 33ABC miR-30e-5p regulation of Delta-like-4. K. Miranda, P. Mehrpouya-Bahrami, P.S. Nagarkatti and CHAIRS: V. KALIA, S. SARKAR M. Nagarkatti. Univ. of South Carolina Sch. of 12:30 The GRB2-associated binding protein 3 is required for Med. (185.6) IL-2 and IL-15 induced NK-cell expansion and limits 1:15 Genome-wide analysis identifies pairs of cis-acting trophoblast invasion during pregnancy. A. Sliz, lncRNAs and protein-coding genes involved in K.C.S. Locker, K. Lampe, A. Godarova, innate immunity. Q. Zhang, T-C. Chao, V.S. Patil, D.R. Plas, E. Janssen, H. Jones, A.B. Herr and Y. Qin, S.K. Tiwari, J. Chiou, A. Dobin, C-M. Tsai, K. Hoebe. Univ. of Cincinnati and Cincinnati Z. Li, J. Dang, S. Gupta, K.B. Urdahl, V. Nizet, Children’s Hosp. Med. Ctr. (181.26) T.R. Gingeras, K.J. Gaulton and T.M. Rana. Univ. 12:45 Type II cytokines in the thymic microenvironment of California, San Diego Sch. of Med., Cold Spring influence T cell negative selection in type one Harbor Lab. and Univ. of Washington Sch. of Med. diabetes. A.N. Cattin-Roy, T.K. Ukah and (185.1) H. Zaghouani. Univ. of Missouri. (181.1) 1:30 Genomic analysis of bone marrow progenitors during 1:00 IL-33 is a cell-intrinsic regulator of early developing B viral infection reveals novel dendritic cell regulators. cell fitness. M.T. Stier, R. Mitra, K. Goleniewska, Y. Jo, K. Zhang, W. Wang and E. Zuniga. Univ. of J. Zhang, C.M. Eischen and R.S. Peebles, Jr. California, San Diego. (185.7) Vanderbilt Univ. Sch. of Med., Thomas Jefferson 1:45 PD-L2 generates a signal through the PD-1 co-receptor Univ. and Vanderbilt Univ. Med. Ctr. (181.15) distinct from that of PD-L1. A. Srinivasamani, Q. Liu 1:15 Human bone marrow plasma cell survival is and M. Curran. Univ. of Texas MD Anderson Cancer independent of APRIL. D.C. Nguyen, C. Saney, Ctr. (185.2) I. Sanz and F.E-H. Lee. Emory Univ. (181.16) 2:00 Regulatory role of Ifit2 in mouse hepatitis virus induced 1:30 Intestinal interleukin (IL)-22RA1 signaling regulates the neuroinflammation. J. Das Sarma, A. Burrows, reciprocal control of IL-22 and onset of high fat diet- P. Kessler, M-H. Hwang, C. Bergmann and induced metabolic disorders. S. Gaudino, H. Huang, G.C. Sen. Indian Inst. of Sci. Educ. and Res., India M. Jean-Pierre, M. Beaupre, X. Lin and P. Kumar. and Cleveland Clin. (185.3) Stony Brook Univ. (181.11) 1:45 IL-17D promotes anti-bacterial immunity in group A Streptococcus infection. A. Washington, A. Valderrama, V. Nizet, N. Varki and J.D. Bui. Univ. of California, San Diego. (181.21)

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2:15 Indole-3-carbinol ameliorates colonic inflammation in 167. CO-INHIBITORY / CO-STIMULATORY SIGNALS DSS-treated, Helicobacter muridarum-infected IN TUMOR THERAPY mice. R.R. Alkarkoushi, U.P. Singh, I. Chatzistamou, M. Bam, Y. Hui, M. Nagarkatti, Block Symposium P. Nagarkatti and T.L. Testerman. Univ. of South SUN. 12:30 PM—ROOM 29ABCD Carolina Sch. of Med. (185.4) CHAIRS: T. CURIEL, Y. ZHU 166. CD8+ T CELL HOMEOSTASIS AND MEMORY 12:30 Humanized PD-1/PD-L1 mice facilitate the direct functional comparison of immune checkpoint Block Symposium inhibitors in vivo. W.J. Barham, S.M. Harrington, SUN. 12:30 PM—ROOM 31ABC X. Liu and H. Dong. Mayo Clin. (195.1) 12:45 CD39+CD8+ T cells exhibit a distinct phenotype among CHAIRS: S. BEDOUI, G.J. MARTINEZ tumor-infiltrating tumor-antigen-specific CD8+ T cells. 12:30 Microbiota-derived butyrate promotes cellular Y. Lee, J. Park, S-H. Park and E-C. Shin. Korea metabolism and memory potential of antigen- Advanced Inst. of Sci. and Technol., South Korea. activated CD8+ T cells. S. Bedoui, K. Binger, (195.2) A. Kallies, S.J. Turner, M. McConville, 1:00 Multidimensional single T cell analysis reveals altered T. Gebhardt and A. Bachem. Univ. of Melbourne, T cell biology upon treatment of murine tumor with Australia. (189.1) checkpoint blockade immunotherapy. S. Rao, 12:45 Microbial exposure expands a Ly6C+ subpopulation of A. Kornberg, S. Lin, K. Gharib, L. Koganti, long lived naive CD8 T cells with a rapid effector J.A. Garcia-Vilas Garcia, K. Masuda and A. Han. function via type I intereferons. M. Jergovic and Columbia Univ. Med. Ctr. (195.3) J. Nikolich-Zugich. Univ. of Arizona. (189.2) 1:15 Human CD96 correlates to NK cell exhaustion and 1:00 PRMT5-mediated arginine methylation controls the predicts the prognosis of human hepatocellular strength of signaling via gc-family cytokines carcinoma. C. Sun, H. Sun, H. Wei, R. Sun and required for T cell maintenance. M. Inoue, Z. Tian. Univ. of Science and Technology of China, K. Okamoto and H. Takayanagi. Univ. of Toyko, China. (195.4) Japan. (189.3) 1:30 Surface and cytoplasmic tumor cell PD-L1 differentially 1:15 STAT1 restrains peripheral naive CD8+ T cell mediate virulence in ovarian cancer and melanoma responsiveness to homeostatic cytokines by through mTOR activation. H.G. Hambright, regulating mTORC1 signaling. Y-C. Kye, C-H. Yun H.B. Gupta, A.S. Padron, R. Vadlamudi, and J-H. Cho. Acad. of Immunology and Y. Chen, P.A. Osmulski and T.J. Curiel. Univ. of Microbiology, Inst. for Basic Sci., South Korea and Texas Hlth. Sci. Ctr., San Antonio. (195.5) Seoul Natl. Univ., South Korea. (189.4) 1:45 B cells produce IL-27 to upregulate PD-L1 expression 1:30 NFAT1 and NFAT2 differentially regulate CTL and promote breast cancer development. H. Yan, differentiation upon acute viral infection. T. Xu, S. Viswanadhapalli, D. Chupp, M. Fernandez, A. Keller and G.J. Martinez. Rosalind Franklin S. Wu, J. Wang, J. Moroney, J. Taylor, J. Im, Univ. of Med. and Sci. (189.5) C. Rivera, Y. Luo, J. Liu, G. Sareddy, P. Casali, 1:45 Themis integrates T cell receptor and cytokine signals in R. Vadlamudi and Z. Xu. Univ. of Texas Hlth. Sci. CD8+ T cells. N.R.J. Gascoigne, J. Brzostek, Ctr. San Antonio. (195.6) X. Zhao, G. Fu, E.W. Chen and M. Mehta. Natl. 2:00 Precisely timed histone deacetylase inhibition creates a Univ. of Singapore, Singapore and Xiamen Univ., highly proliferative intratumoral CD8 T cell population China. (189.6) and sensitizes tumors to checkpoint blockade. 2:00 Identity of recirculating T cells in humans. M. Buggert, T.R. McCaw, M. Liu, M. Li, D. Starenki, S. Nguyen, S. Darko, A. Ransier, D. Douek, A. Bar- S. Cooper, R. Arend, A. Forero, D. Buchsbaum Or, N.K. Bjorkstr¨ om,¨ Y. Dori, M.G. Itkin and and T.D. Randall. Univ. of Alabama at Birmingham M.R. Betts. Karolinska Inst., Sweden, Perelman and HudsonAlpha Inst. for Biotech. (195.7) Sch. of Med., Univ. of Pennsylvania, VRC, NIAID, NIH, Univ. of Pennsylvania, Karolinska Inst., 168. NATIONAL INSTITUTE ON AGING (NIA) Karolinska Univ. Hosp., Sweden and Children’s SYMPOSIUM: IMMUNE METABOLISM, Hosp. of Philadelphia, Penn Medicine, Hospital of INFLAMMATION, AND AGING the Univ. of Pennsylvania. (189.7) 2:15 STAT4 programs CD103- tissue-resident memory cells NIH-Sponsored Session

during infection. T. Bergsbaken, H. Fung, N. Wilson SUN. 3:45 PM—ROOM 25ABC and M. Teryek. Rutgers New Jersey Med. Sch. (189.8) CHAIRS: R.A. FULDNER, C. WEYAND 3:45 Metabolic fitness of T cells in aging and inflammation. C. Weyand. Stanford Univ. Thinking IMMUNOLOGY 2020TM? 4:15 Tissue resident macrophages drive adipose Visit Booth 1007 to book your hotel now. dysfunction during aging. C. Camell. Yale Univ. 4:45 Fasting mimicking diets, immunity, and cancer. V. Longo. Univ. of Southern California.

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5:15 Immunomodulatory mechanisms in the tumor 5:30 C-X3-C chemokine receptor 1 regulates microenvironment. A. Ringel. Harvard Univ. immunopathogenesis during fungal asthma. M.S. Godwin, M.J. Jones, Z. Yu, S. Matalon and 169. THE INTERNATIONAL CYTOKINE AND C. Steele. Univ. of Alabama at Birmingham Sch. of INTERFERON SOCIETY (ICIS) SYMPOSIUM: Med. and Tulane Univ. Sch. of Med. (55.15) CYTOKINES IN IMMUNE-STROMAL CELL INTERACTIONS 171. HUMAN HOST DEFENSE Guest Society Symposium Block Symposium — SUN. 3:45 PM—ROOM 26AB SUN. 3:45 PM ROOM 30AB

CHAIRS: M. MCGEACHY, M. NAIR CHAIRS: R. CASPI, R. MODLIN 3:45 Regulation of immune cells in adipose tissue. L.M. 3:45 Functional impact of a cellular long non-coding RNA on D’Cruz. Univ. of Pittsburgh. CCR5 expression and HIV infection. S. Kulkarni, 4:15 Novel immunoregulatory pathways in helminth infection A. Lied, V. Kulkarni, S. singh, M. Rucevic, through resistin-like molecules and M.P. Martin, F. Chawdhury, S. Le Gall, X. Yu and endocannabinoids. M. Nair. Univ. of Pittsburgh. M. Carrington. Texas Biomed. Res. Inst., Ragon 4:45 Control of cytokine signaling by PTPN2 in rheumatoid Inst. of MGH, MIT and Harvard and NCI, NIH. (120.3) arthritis. N. Bottini. Univ. of California, San Diego. 4:00 Evaluation of T regulatory cells responses in acute and 5:15 Th17 immunity at the oral barrier. N. Moutsopoulus. chronic phases of Chikungunya patients. B.M. Gois, NIDCR, NIH. I.C. Guerra-Gomes, R.F. Peixoto, C.S.N. Dias, P.H.S. Palmeira, J.M.G. Araujo´ and T. Keesen. S 170. MECHANISMS OF ATOPIC DISEASE Federal Univ. of Paraiba, Brazil, Univ. of São U Paulo, Brazil and Federal Univ. of Rio Grande do N Block Symposium Norte, Brazil. (120.15) 4:15 Clonal expansion within circulating plasmablast SUN. 3:45 PM—ROOM 32AB populations lends support for an infectious disease CHAIRS: P. BOYAKA, M. CROFT etiology of Kawasaki disease. M. Hicar, J. Hoffman, H. Sojar and S. Baron. State Univ. of New York, 3:45 An epigenetic link between the gut microbiome and Buffalo. (120.16) immune responses in atopy. A. Cait, 4:30 Endoplasmic reticulum stress regulates M.R. Hughes, M. Bilenky, J. Cait, D. Pepin, immunosuppressive function of myeloid derived M. Hirst, W.W. Mohn and K. McNagny. Univ. of suppressor cells in leprosy. K. Kelly-Scumpia, British Columbia, Canada. (55.7) R. Shirazi and R. Modlin. Univ. of California, Los 4:00 Oral tolerance to peanut allergy is mediated by CTLA-4- Angeles. (120.25) positive regulatory T cells. J.W. Krempski, K. Iijima, 4:45 Commensal microbiota as possible pathobiont in T. Kobayshi and H. Kita. Mayo Grad. Sch. and Mayo autoinflammatory disease. J. Siak, A. St. Leger, Clin. (55.2) K. Raychaudhuri, M. Mattapallil, I.J. Fuss, 4:15 Gut oxidative responses by chronic exposure to R. Goldbach-Mansky, W. Strober and pollutants enhance IgE production via PGE - 2 R.R. Caspi. NEI, NIH, Univ. of Pittsburgh Sch. of dependent mechanism. E. Kim, A. Bonnegarde- Med., NIH and NIAID, NIH. (120.26) Bernard, S.O. Opiyo, B.M. Ahmer, E. Comet- 5:00 Release of transglutaminase 2 from respiratory Boyaka and P.N. Boyaka. The Ohio State Univ. syncytial virus-infected airway epithelial cells and (55.4) its role in disease pathogenesis. Y.M. Hosakote, 4:30 Identification of a novel mechanism of Th2 polarization K. Rayavara and A. Kurosky. The Univ. of Texas in mouse CD4+ T cells through nuclear factor Med. Br. (120.27) erythroid 2-like 2 (Nrf2) regulation. R.C. Kennedy, S. Liu, A.E. Turley, R.A. Freeborn and C.E. Rockwell. Michigan State Univ. (55.3) 172. NOVEL THERAPEUTIC APPROACHES 4:45 The bone marrow-derived Gr-1+CXCR2+ cells are IN LUPUS fi required for T cell in ltration into the skin challenge Block Symposium site to elicit contact hypersensitivity responses are inflammatory monocytes expressing FasL and SUN. 3:45 PM—ROOM 29ABCD perforin. D. Kish and R.L. Fairchild. Cleveland CHAIRS: V. RUSS, V. KUMAR Clin. (55.8) 5:00 Suppression of allergic airway inflammation by MCPIP1 3:45 Innovative drug discovery for autoimmune diseases through suppression of IL-5-producing Th2 cells. aiming at BAFF signaling pathway. K. Yoshimoto, J. Liu, Q. Wang, H. Ning and R. Hou. Saint Louis K. Suzuki, N. Seki, K. Sugahara, K. Chiba and Univ. (55.17) T. Takeuchi. Keio Univ. Sch. of Med., Japan and 5:15 Dimethyl fumarate attenuates T helper type 2‐mediated Mitsubishi Tanabe Pharma Corp. (132.1) allergic airway inflammation by modulating dendritic 4:00 MAP4K3/GLK-induced AhR-RORgt complex is a novel cell function. A.K. Jaiswal, M. Sandey, therapeutic target for GLKhighIL-17Ahigh subpopulation A. Suryawanshi, R.C. Cattley and A. Mishra. of SLE patients. H-C. Chuang and T-H. Tan. Natl. Auburn Univ. (55.16) Hlth. Res. Inst. (132.2)

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4:15 Response Gene to Complement -32 exerts 4:45 IL-36g regulates neutrophil infiltration and limits fl fi proin ammatory and pro brotic effects in immune neuroinvasion in genital HSV-2 pathogenesis. complex mediated glomerulonephritis. V. Rus, J.K. Gardner and M.M. Herbst-Kralovetz. Univ. of A. Tatomir, V. Nguyen, A. Talpos-Caia, Arizona. (75.5) J. Papadimitriou, S. Atamas, I. Luzina, 5:00 Cell type-specific sensing of murine cytomegalovirus S-S.J. Sung, T. Badea and H. Rus. Univ. of through MyD88 and STING control virus infection. Maryland Sch. of Med., Univ. of Virginia Sch. of S.J. Piersma, J. Poursine-Laurent, L. Yang, Med. and NEI, NIH. (132.3) B.A. Parikh and W.M. Yokoyama. Washington 4:30 A rationally engineered DNase1-Fc fusion protein Univ. in St.Louis. (75.6) ameliorates autoimmune glomerulonephritis. 5:15 The innate signaling adaptor MAVS regulates the M. Mouchess, E. Suto, S. Chan, B. Dai, C. Tam, quality of the antibody response to West Nile virus. Y. Cao, M. Darwish, D. He, S. Haller, J. Eastham- D. Schenten, M. O’Ketch, C. Larson and B. Hall. Anderson, Y. Franke, C. Blanchette, W. Lee, Univ. of Arizona. (75.7) C. Austin, R. Lazarus and T. Yi. Genentech, Inc. 5:30 IFN-I blockade improves the immunogenicity of viral (132.4) vector vaccines. N.M. Palacio, T. Dangui, 4:45 Type II NKT cells directed immune regulatory Y. Wang and P.A. Penaloza-MacMaster. Feinberg mechanism(s) control spontaneous lupus nephritis Sch. of Med., Northwestern Univ. and Northwestern in mice. I. Maricic, R. Halder, I. Marrero, Univ. (75.8) D.H. Kono and V. Kumar. Univ. of California, San Diego and Scripps Res. Inst. (132.5) 5:00 Targeting T cell activation and lupus autoimmune 174. AAI-STEINMAN AWARD FOR HUMAN phenotypes with a novel glucose transporter IMMUNOLOGY RESEARCH PRESENTATION inhibitor. W. Li, G. Qu, S-C. Choi, C. Cornaby, AND LECTURE A. Titov, X. Teng, H. Wang and L. Morel. Univ. of The AAI-Steinman Award for Human Immunology Research Florida and RenJi Hosp., Sch. of Med., Shanghai recognizes an individual who has made significant contributions Jiaotong Univ., China. (132.6) to the understanding of immune processes underlying human 5:15 Validation of lanthionine synthetase C-like 2 (LANCL2) disease pathogenesis, prevention, or therapy. as a therapeutic target for systemic lupus Awards Lecture erythematosus. A. Leber, R. Hontecillas, — V. Zoccoli-Rodriguez and J. Bassaganya-Riera. SUN. 4:30 PM BALLROOM 20BCD Landos Biopharma. (132.7) CHAIR: J.L. FLYNN 5:30 A nanoparticle-based approach targeting ion channels for the treatment of Lupus nephritis. A.A. Chimote, Recipient: S.A. Rosenberg. NCI, NIH M. Khodoun, H.J. Duncan, S.K. Kant and L. Conforti. Univ. of Cincinnati and Cincinnati 4:30 Introduction and Award Presentation. J.L. Flynn. Univ. Children’s Hosp. Med. Ctr. (132.8) of Pittsburgh Sch. of Med., AAI President. 4:35 Lymphocytes as a drug for the treatment of human 173. VIRUSES AND INNATE IMMUNE EFFECTORS cancer. S.A. Rosenberg. NCI, NIH. Block Symposium 175. DISTINGUISHED LECTURE SUN. 3:45 PM—ROOM 33ABC GWENDALYN J. RANDOLPH

CHAIRS: V. TARAKANOVA, P. PENALOZA Distinguished Lecture 3:45 Plasmacytoid dendritic cells contribute to HIV diseases SUN. 6:00 PM—BALLROOM 20BCD and viral persistence via IDO-dependent CHAIR: D. MASOPUST mechanisms. G. Li, J. Ma, H. Yu, W. Bi, Y. Wu, L. Cheng and L. Su. UNC-CH and Inst. of Biophysics 6:00 Clearance of molecules and cells from sites of of Chinese Acad. of Sci., China. (75.1) inflammation. G.J. Randolph. Wash. Univ., St. Louis. 4:00 Microglia secrete exosomes during persistent virus infection of the central nervous system that promote demyelinating disease. J.K. Olson and N. Luong. Univ. of Minnesota. (75.2) 4:15 A novel proviral function for IL-17 during gammaherpesvirus infection. C.N. Jondle, K.E. Johnson, C.A. Aurubin, G. Xin, W. Cui, A. Huppler and V.L. Tarakanova. Med. Col. of Wisconsin and Blood Res. Inst. (75.3) 4:30 IL-33 promotes antiviral immunity and protects against congenital Zika disease in mice. Y. Liang, J. Escano and J. Sun. Univ. of Texas Med. Br. (75.4)

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176. IMMUNOLOGY 2019™ GALA Social Event Generously Sponsored by BioLegend

SUN. 7:00 PM—USS MIDWAY MUSEUM At this iconic San Diego destination, you won’t want to miss the opportunity to experience a unique symbol of American freedom. Explore this history-making aircraft carrier while learning all about naval history! Meet up with friends, network with colleagues—and dance! San Diego themed appetizers and dinner stations will be featured along with a sweets station for dessert. The Gala is open to all IMMUNOLOGY 2019™ attendees (21 years or older) and ticketed guests. No children will be permitted. Don’t forget the must haves—your meeting badge (or guest ticket) and drink tickets (attached to your meeting badge)! Come as you are directly from the San Diego Convention Center. Shuttle service will be provided between the Convention Center and the Midway. Shuttles start at 6:30 PM from the Convention Center (there will be signs directing you to the S pick up location) and are staggered to accommodate security U checks prior to embarking onto the Midway. N

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93 SUNDAY—POSTER SESSIONS SUNDAY POSTER SESSIONS

Posters on Display: 9:30 am – 4:30 pm Author Presentation Time: 2:30 pm – 3:45 pm

177. ANTIGEN PROCESSING AND PRESENTATION P314 177.11 MHC class I and II gene-dependent hypersensitivity to nevirapine and efavirenz in Indian HIV-1 Poster Session patients. B.A. Dalal, A. Shankarkumar and A. Pazare. Natl. SUN. 2:30 PM—EXHIBIT/POSTER HALL Inst. of Immunohaematology, India and King Edward Mem. Hosp. and Seth Gordhandas Sunderdas Med. Col., India. P320 177.1 iNKT cell stimulation by glycolipid ligands P316 177.12 Small GTPase Rab8 plays a critical role in B modified from a-galactosylceramide results in differential cell antigen presentation. P.K. Mattila, M. Vainio, interleukin-2 secretion profiles. C.E. Schafer, S. Hernandez Perez, V. Sustar and J. Rajala. Univ. of A.´ Santibañez,´ M. Gutierrez-Gonz´ alez,´ J. Toro, Turku, Finland. K. Marcelain, A.R. Howell, S.A. Porcelli and L.J. Carreño. P317 177.13 Identification of novel subsets among dendritic Facultad de Medicina, Universidad de Chile, Chile, Univ. of cells and macrophages generated from the culture of bone Connecticut and Albert Einstein Col. of Med. marrow. H. In, H.Y. Na, S.H. Ryu, M. Sohn, W. Choi, P303 177.2 Biodegradable nanoparticles containing H.S. Shin, J.S. Park and C.G. Park. Yonsei Univ. Col. of antigen and vitamin D3 efficiently induce antigen-specific Med., South Korea. immune suppression. C-K. Lee, S-U. Jeong, H-H. Jung, P319 177.14 Investigating contributions of the accessory S-H. Kim and K. Kim. Chungbuk Natl. Univ., South Korea molecule HLA-DO to development of autoimmune diseases. and Sahmyook Univ., South Korea. R.A. Welsh, N. Song, C. Foss, T. Boronina, R. Cole and P304 177.3 Induction of antigen-specific immune S. Sadegh-Nasseri. Johns Hopkins Univ. Sch. of Med. suppression using biodegradable nanoparticles containing P323 177.15 Peptide editing and MHC binding mechanisms antigen and dexamethasone. S-H. Kim, J-H. Moon, of tapasin and TAP binding protein related. E.J. Kim, S-U. Jeong and C-K. Lee. Chungbuk Natl. Univ., South Korea. K. Natarajan, L.F. Boyd, J. Jiang, M.G. Mage and P315 177.4 Viperin is not a big gear of immune cell’s D.H. Margulies. LISB, NIAID, NIH. abilities in mouse bone marrow. W. Choi, J. Eom, H.Y. Na, P326 177.16 CpG-A and CpG-B oligonucleotides S.H. Ryu, M. Sohn, H. In, H.S. Shin, J.S. Park, J-Y. Seo and differentially regulate MR1-mediated microbial Ag C.G. Park. Yonsei Univ. Col. of Med., South Korea. presentation. J. Liu, R. Brutkiewicz, S. Liu and J. Wan. P306 177.5 Cell surface MHC-I molecules in dendritic cells Indiana Univ. Sch. of Med. undergo fast recycling but do not replenish the Rab11+Arf6+ P328 177.17 Self-adjuvanting properties of peptide juxtanuclear compartment to support cross-presentation. nanofiber vaccines are dependent on autophagy. Pe.M. Van Endert, S. Montealegre, A. Abramova and J.S. Rudra, A. Khan, J.J. Endsley, A. Zloza and A-F. de Kanter. Inst. Necker Enfants Malades, France. C. Jagannath. Washington Univ. in St. Louis, Houston P309 177.6 Polymorphism in chicken MHC-Y class I Methodist Res. Inst., Univ. of Texas Med. Br. and Rutgers molecules that bind lipid ligands. R. Goto, G. Gugiu, Cancer Inst. of New Jersey. J. Zhang, B. Stadtmueller, P.J. Bjorkman and P331 177.18 Characterizing the MHC-II immunopeptidome M.M. Miller. Beckman Res. Inst., City of Hope, Univ. of of HIV using a cell-free antigen processing system and peptide: Illinois, Urbana-Champaign and California Inst. of Technol. MHC-specific antibodies. S. Sengupta, J. Douglass, P307 177.7 Measuring the molecular mechanisms of tumor T. Boronina, R. Wu, M. Moskovljevic, M. Reed, J. Yu, antigen cross-presentation in dendritic cells and macrophages. Y. Tabdili, R. Siliciano and S. Sadegh-Nasseri. Johns E.M. Muntjewerff, F. Bianchi, S. Maassen and G. van den Hopkins Univ. Sch. of Med. Bogaart. Radboud Inst. for Molecular Life Sci., The P300 177.19 Identification of specific T lymphocytes against Netherlands and Univ. of Groningen, The Netherlands. to an IFNg inducible lysosomal thiol reductase-dependent, P311 177.8 Single-cell RNA sequencing reveals different class II MHC-associated epitope in GILT -/- mice. X. He, subsets of macrophage and dendritic cells in human skin. H. Dai, E. Reyes-Vargas and P.E. Jensen. Univ. of Utah D. Xue, T. Tabib, C. Morse and R. Lafyatis. Sch. of Sch. of Med. Pittsburgh. P301 177.20 MHC class II conformers drive differential B cell P321 177.9 Comprehensive immunopeptidome analysis of activation. J.R. Drake. Albany Med. Col. I-Ab-bound peptides from thymus and splenic B cells in C57BL/ P302 177.21 Molecular mechanisms underlying the 6 mice. P.P. Nanaware and L.J. Stern. Univ. of glycation induced-impairment of antigen processing and Massachusetts Med. Sch. presentation in diabetic (T2DM) patients and ob/ob mice. P313 177.10 Measurement of MHC-peptide interaction L. Santambrogio, C. Clement, M.P. Negroni, through cell-surface expression and stability assay improves P. Nanaware, K. Morozova and L. Stern. Albert Einstein screening of potential CD4+ T-cell epitopes. H. Miyadera, Col. of Med. and Univ. of Massachusetts Med. Sch. H. Nagai, T. Yoshiyama, K. Tokunaga and Y. Hoshino. P305 177.22 Splenic CD169+ marginal zone macrophages Univ. of Tsukuba, Japan, Tokyo Natl. Hosp., Japan, Fukujuji directly cross-prime CD8+ T cells in vivo using a vacuolar Hosp., Japan, Univ. of Tokyo, Japan and Natl. Inst. of processing pathway. P.M. Van Endert, F. Mauvais, Y. Hamel, Infectious Dis., Japan. J. Diana and M. Garfa. Institut Necker-Enfants Malades, France and INSERM UMS24, France.

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P308 177.23 Wdfy4-deficiency reveals a critical role for P332 177.33 Batf3-dependent dendritic cells are required to cross-presentation in anti-viral and anti-tumor responses. present cell-associated antigen to CD4 T cells. S.T. Ferris, D.J. Theisen, J.T. Davidson, C.G. Briseño, M. Gargaro, V. Durai, R. Wu, T.L. Murphy and K.M. Murphy. Washington E.J. Lauron, Q. Wang, P. Desai, V. Durai, P. Bagadia, Univ. Sch. of Med. in St. Louis and Washington Univ. in St. J.R. Brickner, W.L. Beatty, H.W. Virgin, W.E. Gillanders, Louis. N. Mossamaparast, M.S. Diamond, L.D. Sibley, W. Yokoyama, R.D. Schreiber, T.L. Murphy and 178. BASIC AUTOIMMUNITY: ROLE OF MICROBES K.M. Murphy. Washington Univ. in St. Louis, Univ. of Perugia, Vir Biotechnology and HHMI. Poster Session P310 177.24 The human NK cell receptor KIR2DS4 detects SUN. 2:30 PM—EXHIBIT/POSTER HALL a conserved bacterial epitope presented by HLA-C. E.O. Long and MJ.W. Sim. Natl. Inst. of Allergy and Infectious Dis. P334 178.1 VSV-primed CD8+ T cells suppress P312 177.25 Investigating a role for HLA-DO in the autoreactive germinal centers. H.K. Kole, B. Scott, development of CD4 memory cells. N. Song, R.A. Welsh S. Crampton, G. Sule, J. Deane and S. Bolland. NIAID, NIH. and S. Sadegh-Nasseri. Johns Hopkins Univ. P336 178.2 A single infection with a malaria parasite P318 177.26 Antigen processing and autophagy function in protects mice from lethal autoimmune glomerulonephritis. adjuvant-treated dendritic cell. K. Hashimoto, T. Ootomo, L. Amo, H.K. Kole, B. Scott, I.N. Moore, C-F. Qi, J. Wu, A. Hasegawa, R. Kotera, D. Kobayashi and T. Nakayama. H. Wang and S. Bolland. NIAID, NIH and Comparative Med. Chiba Inst. of Tech., Japan, Yamaguchi Univ., Japan, Chiba Branch, Infectious Dis. Pathogenesis Section, NIAID, NIH. Inst. of Tech. Grad. Sch. of Engin., Japan and Chiba Univ. P332 178.3 Interactions between the host genome and the Grad. Sch. of Med., Japan. gut microbiome determine susceptibility to CNS autoimmune ¨ P322 177.27 Parkinson’s disease-related proteins PINK1 disease. T.L. Montgomery, Q. Fang, A. Kunster, H. Busch, S and Parkin are major regulators of the immune system. C. Teuscher and D. Krementsov. Univ. of Vermont and Univ. of Lubeck,¨ Germany. U D. Matheoud, T. Cannon, A. Voisin, A-M. Penttinen, N L. Ramet, A. Fahmy, C. Ducrot, A. Laplante, P335 178.4 Periodontal disease: from infection to M-J. Bourque, L. Zhu, A. Le Campion, H. McBride, autoimmunity. H.S. Garzon and L. Suarez. Antonio Narino S. Gruenheid, L-E. Trudeau and M. Desjardins. Centre de Univ., Colombia and Natl. Univ. of Colombia, Colombia. Recherche du Centre Hosp.ier de l’Universite´ de Montreal,´ P337 178.5 Heightened levels of antimicrobial response Canada, Canada, McGill Univ., Canada and Universitede´ factors in patients with systemic lupus erythematosus. Montreal,´ Canada. P. Ayyappan, R.Z. Harms, J.H. Buckner and P324 177.28 The non-classical MHC-II molecule H2-O (DO) N.E. Sarvetnick. Univ. of Nebraska Med. Ctr. and Benaroya is required for efficient recovery from influenza A infection. Res. Inst. L. Stern and M.M. Jurewicz. Univ. of Massachusetts Med. P338 178.6 PLD3 and PLD4 are single-stranded acid Sch. exonucleases that regulate endosomal nucleic-acid sensing. P325 177.29 Epitope mapping of Mycobacterium D. Nemazee, A.L. Gavin and D. Huang. Scripps Res. Inst. tuberculosis proteins using a non-human primate model of P339 178.7 Aberrant MDA5 signaling and IFN-b synthesis infection. N.L. Grant, A.J. Balgeman, A.L. Ellis, elicit protection from coxsackievirus-accelerated type 1 S.L. O’Connor, C.A. Scanga and J.L. Flynn. Univ. of diabetes. S.I. Blum, A.R. Burg, Y-G. Chen and H.M. Tse. Pittsburgh Grad. Sch. of Publ. Hlth., Univ. of Wisconsin- Univ. of Alabama, Birmingham and Med. Col. of Wisconsin. Madison and Univ. of Pittsburgh Sch. of Med. P340 178.8 Loss of gut barrier integrity triggers P327 177.30 An engineered vaccine encompassing an autoimmune diabetes through microbiota-induced activation MHC class I antigen presenting molecule induces self- of islet-reactive T cells. M. Falcone, C. Sorini, I. Cosorich, reacting CTL in a setting of profound tolerance. L.R. Pease, M. Lo Conte, F. Facciotti, F. Sanvito, R. Ferrarese and C.A. Parks, D. Kranz and M. Barry. Mayo Clin., Columbia F. Canducci. Ospedale San Raffaele, Karolinska Instit., Univ. Med. Ctr. and Univ. of Illinois, Urbana-Champaign. Sweden, IEO and Univ. of Insubria. P329 177.31 Getting in the groove: editing of MHC-I antigen P341 178.9 Synergetic effect of an autoantigen CII and a repertoires by molecular chaperones is governed by a network mycoplasma superantigen on the onset and development of of protein dynamics. N. Sgourakis, A. McShan, K. Natarajan, autoimmune arthritis in mice. H-H. Mu, S. Jiang, X. Wang, J. Jiang, J. Park, S. Overall, J.S. Toor, V. Kumirov, C. Meaney and J. Wang. Univ. of Utah Sch. of Med. D. Flores-Solis, M. Badstubner, E.L. Kovrigin, P342 178.10 Pregnancy and lactation interfere with the C.R. Bagshaw, J. Pallesen, E. Procko and response of autoimmunity to modulation of gut microbiota. D.H. Margulies. Univ. of California, Santa Cruz, NAIAD, Q. Mu, X. Cabana-Puig, B. Swartwout, L. Abdelhamid, NIH, Univ. of Illinois, Urbana-Champaign, Marquette Univ. T.E. Cecere, H. Wang, C.M. Reilly and X.M. Luo. Virginia and Indiana Univ. Tech and Col. of Animal Sci., Zhejiang Univ., China. P330 177.32 High GILT expression and an active and intact P343 178.11 Induction of regulatory B cells by bacterial DNA fi MHC class II antigen presentation pathway are associated with in the gut microbiota at early age is bene cial in lupus-prone improved survival in melanoma. K. Hastings, L. Meador, mice. Q. Mu, B. Swartwout, X. Cabana-Puig, J. Grieco, H. Menon, Y-K. Lu, J. Brill, H. Cui, D.J. Roe, T.E. Cecere and X.M. Luo. Virginia Tech. D.J. DiCaudo and K.H. Buetow. Univ. of Arizona, Arizona P344 178.12 The gut microbiota from lupus-prone fl State Univ. and Mayo Clin. B6.Sle1.Sle2.Sle3 (TC) induces in ammation via a mechanism other than bacterial translocation. J.M. Brown, S-C. Choi and L. Morel. Univ. of Florida.

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P345 178.13 Linking diet, gut microbiota and autoimmunity: P357 179.7 Salivary IgA as biomarker of disease activity in a phytoestrogen diet alters the gut microbiota and influences systemic lupus erythematosus. S. Romero, E.S. Sanchez-´ experimental autoimmune encephalomyelitis (EAE). Salguero, J.J. Torres-Ruiz, C. Nuñez-´ Alvarez,´ L. Santos- S.N. Freedman, S. Shahi, K. Zarei, A. Gupta, N. Guseva, Argumedo, R. Chacon-Salinas,´ D. Gomez-Mart´ ´ın and A. Bossler, K.L. Legge and A.K. Mangalam. Carver Col. of J.L. Maravillas-Montero. UNAM, Mexico, CINVESTAV-IPN, Med. Univ. of Iowa and Dept. of Pathology, Univ. of Iowa. Mexico, INCMNSZ, Mexico and ENCB, IPN, Mexico. P346 178.14 IL-17A control CNS inflammatory disease by P358 179.8 Analysis of age-associated B cells in systemic regulating Treg cells through modulation of gut microbiota in lupus erythematosus patients. V.A. Sosa HernAndez,´ HLA class-II transgenic mice model of multiple sclerosis (MS). I.C. Navarro-Hernandez, J.J. Torres-Ruiz, L.P. Whitall, S.K. Shahi, S.N. Freedman, A.C. Murra, K. Zarei, D. Gomez-Mart´ ´ın, L. Santos-Argumedo and N.V. Guseva, K.G. Corley, A. Bossler, N.J. Karandikar J.L. Maravillas-Montero. CINVESTAV-IPN, Mexico, and A.K. Mangalam. Carver Col. of Med., Univ. of Iowa. INCMNSZ, Mexico and UNAM, Mexico. P347 178.15 Microbial exposure and autoimmunity in the P359 179.9 Age-associated B cells in early drug-naive etiopathogenesis of Sarcoidosis. B. Allushi, H. Bagavant, rheumatoid arthritis patients. G.V. Vidal-Pedrola, J. Papinska, C.G. Montgomery and U.S. Deshmukh. J. Cameron, A. Pratt, A. Mellor, D. Scheel-Toellner, Oklahoma Med. Res. Fndn. J. Isaacs and A. Anderson. Newcastle Univ., United P348 178.16 Dysbiosis reprograms the differentiation of Kingdom and Univ. of Birmingham, United Kingdom. thymus-derived regulatory T cells. K. Wang, B-H. Yang and P360 179.10 Novel role of T cells to induce development of W. Fu. Univ. of California, San Diego. proliferative plasmablasts in systemic lupus erythematous. P349 178.17 B cells, bugs, bowels, and bones: Bruton’s O.A. Ojo, S. Liu, Q. Wu, P.A. Yang, D.K. Crossman, tyrosine kinase deficiency alters gut B lymphocyte W. Chatham, H-C. Hsu and J.D. Mountz. Univ. of populations and IgA recognition of commensal bacteria in Alabama, Birmingham and Univ. of Alabama Sch. of Med. autoimmune arthritis. R. Bonami, C. Thurman, L. Nyhoff, P361 179.11 Abnormal B cell development in an SLE patient B. Barron and P.L. Kendall. Vanderbilt Univ. Med. Ctr. suffering from immunothrombocytopenia. Y.S. Choi and P350 178.18 Androgens may influence lupus development J. Kim. Seoul Natl. Univ. Col. of Med., South Korea. via an effect on the composition and metabolic activities of P362 179.12 Divergent roles for TLR7 and TLR9 in intestinal microbiota in BWF1 mice. J.W. Harder, J. Ma, modulating the NFkB pathway in B cells. K.K. Nundel, A. Chhabra, P. Alard, X. Zhang, F. Yuan, R. Ferrill, S. Moses, J.H. Shim and A. Marshak-Rothstein. Univ. of Y. Hua and M.M. Kosiewicz. Univ. of Louisville. Massachusetts Med. Sch. P363 179.13 Defining the mechanisms of B-cell induced 179. BASIC AUTOIMMUNITY: B CELLS autoimmune disease. C.A. Bazile, J.A. Wright, J.C. Boucher, E. Kleiman, E.S. Clark and W.N. Khan. Poster Session Univ. of Miami. SUN. 2:30 PM—EXHIBIT/POSTER HALL P364 179.14 The contribution of anergic B cells to protective immunity. A. Agazio, K. Shotts-Schroeder, M.L. Santiago, P351 179.1 Systemic activation of B and CD4 but not CD8 R.A. Pelanda and R.M. Torres. Univ. of Colorado Anschutz cells drives early disease in lupus prone mice, while Med. Campus. fi macrophages, CD4 and CD8 cells in ltrate the kidney with P365 179.15 Ikaros regulates chromatin landscape in the exclusion of B cells. J. Wu, H. Wang, L. Amo, B. Scott, mature B cells, and is critical for B cell tolerance. H.K. Kole and S. Bolland. NIAID, NIH. P.D. Rodriguez, W. Howell, E. Amiel, S. Frietze and P352 179.2 Discovery of autoantibodies associated with H. Schjerven. Univ. of Vermont and Univ. of California, San psoriatic arthritis. T. Wu, Y. Yuan and S.K. Tyring. Univ. of Francisco. Houston and Ctr. for Clin. Studies. P366 179.16 Ikaros mutations can bypass the requirement P353 179.3 The glycosylation and glycoprotein signature for second co-stimulatory signal and lead to break of B-cell of immunoglobulins in patients with autoimmune liver diseases. tolerance. H. Schjerven, P.D. Rodriguez, W. Howell, W. Zhang, X. Zhou, J. Muchena, Z. Shuai, T.Y. Sun, J. Vestbostad, S. Frietze and H. Schjerven. Univ. of G-X. Yang, C.H. Liu, S. Dhaliwal, P. Invernizzi, California, San Francisco, Univ. of Vermont and KG Jebsen C. Bowlus, P.S.C. Leung, C. Lebrilla and E. Gershwin. Centre for B Cell Malignancies, Oslo Univ. Hosp., Norway. Univ. of California, Davis, First Affiliated Hosp. of Anhui Med. Univ., China, Beijing 302 Hosp., China and Univ. of 180. BASIC AUTOIMMUNITY: ANTIGEN AND Milan-Bicocca, Italy. P354 179.4 Mechanisms for secretion of antibodies with INNATE IMMUNITY “anti-self” reactivity by the human obese adipose tissue. Poster Session D. Frasca, A. Diaz, M. Romero and B. Blomberg. Univ. of — Miami. SUN. 2:30 PM EXHIBIT/POSTER HALL P355 179.5 Type I IFN and IL-4R define B cell checkpoint P367 180.1 Increased immune surveillance of neuron- defects in systemic lupus erythematosus. J.D. Mountz, S. Liu, restricted antigen during demyelination leads to axon loss Q. Wu, P. Yang, W.A. Essman, O.A. Ojo, B. Luo, M. Gao, perpetrated by CD8+ T cells. B.D.S. Clarkson, E.M. Grund, J.Y. Chen, I. Sanz, W.W. Chatham and H-C. Hsu. Univ. of K. Mirchia, M.M. Standiford and C.L. Howe. Mayo Clin. and Alabama at Birmingham and Emory Univ. Mayo Grad. Sch. P356 179.6 Characterization of CD11c+ B-cells from human blood. S.F. Calbo, M. Demeules, C. Derambure, G. Riou, M. Vaillant, O. Boyer, P. Joly and M-L. Golinski. Inserm U1234, France.

96 SUNDAY—POSTER SESSIONS

P369 180.2 Peptides of endogenous retrovirus Gag gene P405 180.17 The metabolic modulator metformin affects the variants are not agonistic ligands for autoreactive T cells in activation and survival of murine dendritic cell subsets. non-obese diabetic mice. Y.D. Dai, R. Bashratyan, S. Gallucci, M. Chakhtoura, M.H. Lee and C.C. Qiu. Lewis K. Marquardt, W-Y. Hu, L. Evans and K. Haskins. Katz Sch. of Med., Temple Univ. Biomedical Res. Inst. of Southern California, Scripps Res. P406 180.18 Regulation of plasmacytoid dendritic cells Inst., Biosettia, Inc, NIAID and Univ. of Colorado Sch. of Med. function via ER stress pathway. V. chaudhary and P370 180.3 Small numbers of T cells specific to different F.J. Barrat. Hosp. for Special Surgery Autoimmunity and myelin-antigens cooperate to induce autoimmunity in a murine Inflammation Res. Program. model of multiple sclerosis. R.R. Robinson, E.M. Rojano and P368 180.19 Antigen-presenting cells from naive mice T. Forsthuber. Univ. of Texas, San Antonio. constitutively present the T cell epitope of SERCA2a and P371 180.4 Beta cells activate islet resident macrophages induce inflammatory cytokine production in antigen-specific in a culture bioassay. M.M-U. Zaman and P. Zakharov. T cells. J. Reddy, R. Arumugam, B. Yalaka, Washington Univ. Sch. of Med. C. Massilamany, S. Ali, J-J. Riethoven and X. Sun. Univ. P372 180.5 Pancreatic beta cells are constantly interacting of Nebraska, Lincoln. with the immune system. X. Wan, B. Zinselmeyer, P375 180.20 Molecular targets of inflammation in pancreatic P. Zakharov, A.N. Vomund, C.F. Lichti and E.R. Unanue. endocrine cells in type 1 diabetes. C. Mora, E. Sala, Washington Univ. Sch. of Med., St. Louis. N.A. Saavedra-Avila,´ U. Sengupta, C. Vived, P374 180.6 Targeted over-expression of S100B in the J. Verdaguer, T. Stratmann and J. Lahti. Univ. of Lleida, retina of transgenic mice induced exacerbated experimental Spain and St. Jude Children’s Res. Hosp. autoimmune uveitis. C-R. Yu, O. Ogbonna, H. Lee, J.K. Choi, Y. Jittayasothorn, L. Li and C.E. Egwuagu. NEI, NIH. 181. CYTOKINE AND CHEMOKINE CONTROL P403 180.7 Antigen dose affects disease kinetics in a OF IMMUNITY S murine model of demyelinating disease. C.A.M. Gavile, U Poster Session A. Alexander, F. Adler and B.D. Evavold. Univ. of Utah. N P373 180.8 Matrix metalloproteinase-28 alters cellular SUN. 2:30 PM—EXHIBIT/POSTER HALL energetics in macrophages, influencing polarization and activation. D. Tokmina-Roszyk, L.C. Onwuha-Ekpete, P412 181.1 Type II cytokines in the thymic fl M. Refai, M. Tokmina-Lukaszewska, B. Bothner and microenvironment in uence T cell negative selection in type G.B. Fields. Florida Atlantic Univ. and Montana State Univ. one diabetes. A.N. Cattin-Roy, T.K. Ukah and H. Zaghouani. P376 180.9 Blood monocyte subsets are dysregulated and Univ. of Missouri. fi respond with high IL-6 secretion in patients with systemic P417 181.2 De ning the phenotype and function of sclerosis. K. Friedrich, C. Bearwald, M. Pierer and granzyme A expressing T-helper cells. T.A. Hayes and M. Rossol. Leipzig Univ., Germany. M.H. Kaplan. Indiana Univ. Sch. of Med. P377 180.10 Multiple Myd88-dependent Toll-like receptor P416 181.3 Expression of GM-CSF is regulated by signaling pathways mediate inflammation in a mouse model transcription factor Fli-1. X. Zhang, M. Lennard Richard, of primary Sjogren¨ ’s syndrome. J. Kiripolsky, E.M. Kasperek, X. Wang, B. Henry, P. Li, H. Fan and G.S. Gilkeson. Med. G. Yu and J.M. Kramer. State Univ. of New York, Buffalo. Univ. of South Carolina. fl P378 180.11 Natural killer cell re-modeling of the extra- P420 181.4 IL-6 overexpression triggers in ammation cellular matrix by the degradation of hyaluronan: potential through its only relevant receptor IL-6R. I. Mufazalov, role in type 1 diabetes. B.E. Fuchs, V. Wall, I. Kang, M. Brandfald, C. Schelmbauer, D. Andruszewski, G. Workman, S. Evanko, T. Wight and S.A. Long. Y. Tang, J. Masri, S. Karbach, C. Eich, T. Wunderlich, Benaroya Res. Inst. T. Korn, J. Bluestone and A. Waisman. Johannes Gutenberg Univ. of Mainz, Germany, Inst. for Genetics, P379 180.12 The role of CB1 in experimental autoimmune encephalomyelitis. J.M. Nichols and B. Kaplan. Mississippi Germany, Tech. Univ. of Munich, Germany and Univ. of State Univ. California, San Francisco. P400 180.13 MIF and MIF2 have distinct but synergistic P413 181.5 A directly GP130-targeting small molecule roles in CIA pathogenesis. E.H. Doherty, P.V. Tilstam and ameliorates collagen-induced arthrites by inhibiting IL-6/ R. Bucala. Yale Univ. Sch. of Med. GP130 signaling and Th17 differentiation. H.J. Kim, P401 180.14 Bromodomain inhibition instructs Y-H. Park and T-H. Heo. Catholic Univ. of Korea, South Korea. macrophages to promote beta cell proliferation and P422 181.6 Expression and function of IL-1 receptor type 2 suppress autoimmune diabetes. M. Yang, K. Wang and regulating human Th17 responses. W-W. Lee, D.H. Kim and W. Fu. Univ. of California, San Diego. S. Cho. Seoul Natl. Univ. Col. of Med., South Korea. P402 180.15 STING-mediated chronic activation of ER P428 181.7 Nrf2 selectively regulates IL-22 and IL-17A stress through disrupting calcium homeostasis primes production in Th17 cells. X. Lin, S. Gaudino, J. Kolls and T cells for cell death. J. Wu and N. Yan. Univ. of Texas P. Kumar. Stony Brook Univ. and Tulane Univ. Sch. of Med. Southwestern Med. Ctr. P409 181.8 The role of Th17 lymphocytes in drug-resistant P404 180.16 Pulmonary involvement in a mouse model of epilepsy. O. Ouedraogo,´ H. Jamann, A. Daigneault, Sjogren¨ ’s syndrome induced by activation of the STING M.L. Clenet, B. Lahav, A. Berub´ e,´ P. Cossette, pathway. J.A. Papinska, G. Gmyrek, R.S. Srinivasan, M. Keezer, D.K. Nguyen and C. Larochelle. Univ. of U. Deshmukh and H. Bagavant. Oklahoma Med. Res. Fndn. Montreal, Canada.

97 SUNDAY—POSTER SESSIONS

P411 181.9 Complement activation causes oncogene P419 181.22 Transcriptomic analysis of human IL-7 receptor expression in Gaucher disease. M.K. Pandey, alpha low and high effector memory CD8+ T cells reveals an age- A.F. Magnusen, M.A. McKay, T.C. Nyamajenjere, associated signature linked to influenza vaccine response in B.A. DiPasquale, D.N. Magnusen, R. Rani, D. Witte, older adults. H-J. Park, M.S. Shin, M. Kim, J. Bilsborrow, G.A. Grabowski and J. Kohl¨ . Cincinnati Children’s Hosp. S. Mohanty, R.R. Montgomery, A. Shaw, S. Yoo and Med. Ctr. I. Kang. Yale Univ. Sch. of Med. and Cedars-Sinai Med. Ctr. P425 181.10 Defining the role of interferon signaling in P424 181.23 IL-27-dependent STAT1 activation is mouse models of Down syndrome. K. Tuttle, K.A. Waugh, enhanced in CD4 T cells from HIV infected patients. R. Minter, K.D. Sullivan and J.M. Espinosa. Linda Crnic Inst. J. Cheng, J. Kumar, P. Kumar and M. Catalfamo. for Down Syndrome. Georgetown Univ. Sch. of Med. P430 181.11 Intestinal interleukin (IL)-22RA1 signaling P431 181.24 IL-2 signals program the fate of exhausted CD8 regulates the reciprocal control of IL-22 and onset of high fat T cells. V. Kalia, H. Xiao, Y. Yuzefpolskiy and S. Sarkar. diet-induced metabolic disorders. S. Gaudino, H. Huang, Univ. of Washington and Seattle Children’s Res. Inst. M. Jean-Pierre, M. Beaupre, X. Lin and P. Kumar. Stony P410 181.25 IL-21 produced by CD4+ T cells drives Brook Univ. differentiation of CD8+ T cells during polyomavirus P421 181.12 Involvement of CCR5 in bone resorption encephalitis. H. Ren, T. Mockus, F. Shwetank, M. Lauver, associated to apical periodontitis. A. De Rossi, C. Netherby, G. Jin and A. Lukacher. Pennsylvania State S.Y.F. Alves, P. Nelson-Filho, R.A.B. Silva and Univ. Col. of Med. L.A.B. Silva. Univ. of São Paulo, Brazil. P414 181.26 The GRB2-associated binding protein 3 is P418 181.13 Clinicopathological and prognostic required for IL-2 and IL-15 induced NK-cell expansion and significance of CCR5/CCL5 axis in hepatocellular limits trophoblast invasion during pregnancy. A. Sliz, carcinoma. S.K. Singh, M.K. Mishra, J.W. Lillard and K.C.S. Locker, K. Lampe, A. Godarova, D.R. Plas, R. Singh. Morehouse Sch. of Med. and Alabama State Univ. E. Janssen, H. Jones, A.B. Herr and K. Hoebe. Univ. of P426 181.14 Weighted gene correlation network analysis of Cincinnati and Cincinnati Children’s Hosp. Med. Ctr. ovarian cancer driven by CXCL13-CXCR5 interactions. P433 181.27 Elucidating the role of cytokine signaling in the K. Carey, T.L. Griffen, C.D. Young, C.D. Dill and homeostasis of innate immune cells with JAK inhibitors. J.W. Lillard. Morehouse Sch. of Med. L. Vian, M. Lee, G. Sciume,` N. Gazaniga, S. Dell’Orso, P429 181.15 IL-33 is a cell-intrinsic regulator of early S. Brooks and M. Gadina. NIAMS, NIH and Sapienza developing B cell fitness. M.T. Stier, R. Mitra, Univ. of Rome, Italy. K. Goleniewska, J. Zhang, C.M. Eischen and P434 181.28 The tumor necrosis factor superfamily member R.S. Peebles, Jr. Vanderbilt Univ. Sch. of Med., Thomas RANKL suppresses effector cytokine production in group 3 Jefferson Univ. and Vanderbilt Univ. Med. Ctr. innate lymphoid cells. J. Bando, S. Gilfillan, C. Song, P432 181.16 Human bone marrow plasma cell survival is K.G. McDonald, S.C-C. Huang, R.D. Newberry, independent of APRIL. D.C. Nguyen, C. Saney, I. Sanz and Y. Kobayashi, D. Allan, J.R. Carlyle, M. Cella and F.E-H. Lee. Emory Univ. M. Colonna. Washington Univ. Sch. of Med., NGM P415 181.17 Multivariate transcriptome analysis of CXCR5- Biopharmaceuticals, Case Western Reserve Univ., CXCL13 signaling in unmutated and mutated CLL. Masumoto Dent. Univ., Japan, NHLBI, NIH and Univ. of T.L. Griffen, C. Young, C.D. Dill, K. Carey, O. Adebayo, Toronto, Canada. S. Nunez and J.W. Lillard. Morehouse Sch. of Med. P407 181.18 TNF-a induces a pro-inflammatory phenotypic 182. IMMUNE MECHANISMS OF HUMAN DISEASE shift in monocytes through ACSL1: relevance to metabolic inflammation. F. Alrashed, Z. Ahmad, M.A. Iskandar, Poster Session J. Tuomilehto and R. Ahmad. Dasman Diabetes Inst., SUN. 2:30 PM—EXHIBIT/POSTER HALL Royal Col. of Surgeons in Ireland and Danube Univ., Krems, Austria. P435 182.1 Bone marrow transplantation rescues fi P423 181.19 IL-22 reduces the mortality of type 2 diabetes monocyte recruitment defect and improves cystic brosis in mellitus mice infected with Mycobacterium tuberculosis. mice. Z. Fan, J. Miller, R. Herro, E. Ehinger, D.J. Conrad, D. Tripathi, R.K. Radhakrishnan, R. Sivangala Thandi, Z. Mikulski, Y.P. Zhu, P.M. Marcovecchio, C.C. Hedrick and P. Paidipally, K.P. Devalraju, V.S.K. Neela, K. Ley. La Jolla Inst. for Allergy and Immunology and Univ. of A.R. Tvinnereim, V.L. Valluri and R. Vankayalapati. Univ. California, San Diego. fi of Texas Hlth. Sci. Ctr., Tyler and Bhagwan Mahavir Med. Res. P436 182.2 Gaqdeciency accelerates the onset of Centre, India. experimental lupus. Y. He, H. Qian and G. Shi. First fi P408 181.20 RhoA regulates Th17 cells and hepatic fibrosis Af liated Hosp. of Xiamen Univ., China. induced by Schistosoma japonicum infection. J-Q. Yang, P437 182.3 Potential role of myeloid-derived suppressor fi Y. Yang, W. Zhou, C. Mei, P. Dong, S. Mo, Y. Zheng and cells in pulmonary brosis. T. Liu, A. Rinke, K. Flaherty F. Guo. Jiangsu Inst. of Parasitic Dis., China and Cincinnati and S.H. Phan. Univ. of Michigan. Children’s Hosp. Med. Ctr. P438 182.4 Morphometric and cytologic characterization of P427 181.21 IL-17D promotes anti-bacterial immunity in tertiary lymphoid follicles in resected bowel of patients with ’ group A Streptococcus infection. A. Washington, diverticulitis, ulcerative colitis, and Crohn s disease. A. Valderrama, V. Nizet, N. Varki and J.D. Bui. Univ. of A.L. Mauner and E.N. McNamee. Univ. of Colorado Sch. of California, San Diego. Med. and Maynooth Univ., Co. Kildare.

98 SUNDAY—POSTER SESSIONS

P439 182.5 Genetic immune pathologies are common in P450 182.16 Peripheral blood neutrophil and G-CSF levels Azerbaijan. N. Fazal, S. Ibrahimova, V. Mammadova, are linked to aztreonam lysine use in humans with cystic G. Aliyeva and G. Nasrullayeva. Chicago State Univ., fibrosis. N.D. Wright and J.R. Gordon. Univ. of Azerbaijan Medical Univ., Azerbaijan and Inst. of Saskatchewan, Canada. Hematology and Blood Transfusion, Azerbaijan. P451 182.17 WITHDRAWN P440 182.6 Antigenic function of 14-3-3z is a novel tool to P452 182.18 Upregulation of SLAMF3 on human T cells is treat rheumatoid arthritis. R. Chakravarti, J. McGowan, induced by palmitic acid through the STAT5-PI3K/Akt pathway C. Peter, Y. Zhang, B. Veerman, R. Rahaman and B. Joe. and features the chronic inflammatory profiles of type 2 Univ. of Toledo and Univ. of Toledo Col. of Medicine and Life diabetes. Z. Hu, T. Zhou, G. Wang and Y-G. Yang. Jilin Sciences. Univ., China. P441 182.7 Relationship between autoimmunity and P453 182.19 Understanding the role of IL-33 in lifestyle. K. Kimura. Japan Univ. of Econom., Japan. endometriosis associated inflammation and pathology. P442 182.8 Cell bound complement activation products J.E. Miller, M. Koti and C. Tayade. Queen’s Univ., Canada. alone and in combination with low serum complement C3 or P454 182.20 Inflammation in PTSD is a consequence of C4 have superior diagnostic performance in systemic lupus dysregulated WNT signaling orchestrated by long non- erythematosus. A. Weinstein, D.J. Wallace, C. Putterman, coding RNA LINC00926 and lysine methyltransferase MLL1. C. Arriens, A. Askanase, K.C. Kalunian, C.E. Collins, M. Bam, X. Yang, P.S. Nagarkatti and M. Nagarkatti. Univ. of A. Saxena, E.M. Massarotti, R.V. Alexander, C. Ibarra, South Carolina. W. Chatham, R. Ramsey-Goldman, S. Narain, P455 182.21 PAM3 supports the generation of M2-like T. Chandra, J. Ahearn and S. Manzi. Exagen, Cedars macrophages from lupus patient monocytes and improves Sinai Med. Ctr., Albert Einstein Col. of Med., Oklahoma disease outcome in murine lupus. B.H. Horuluoglu, Med. Res. Fndn., Columbia Univ. Med. Ctr., Univ. of D. Bayik, N. Kayraklioglu, E. Goguet, L.P. Blanco, S California, San Diego, MedStar Washington Hosp. Ctr., New M.J. Kaplan and D.M. Klinman. NCI, NIH and NIAMS, NIH. U York Univ. Sch. of Med., Harvard Med. Sch., Univ. of Alabama P456 182.22 Alternative macrophage programming after N Sch. of Med., Feinberg Sch. of Med., Northwestern Univ., clot phagocytosis. A. Schenkel, J. Aragon, C. Mills, Hofstra Northwell Sch. of Med., EmpiriQA and West Penn M. Glennon, N. Garcia, C. LaFleur and K. Horn. Colorado Allegheny Hlth. Syst. State Univ., Texas A&M Vet. Med. and Univ. of Colorado Sch. P442 182.8 Adventitial stromal cells define group 2 innate of Med. lymphoid cell tissue niches. T. Dervieux. Exagen. P457 182.23 Elevated expression levels of the voltage- P443 182.9 TGF-beta in the UCB-MSCs inhibit TNF-alpha gated sodium channel 1.7 and BAFF receptor in peripheral in human mast cells and atopic dermatitis. H-H. Park, Y-S. Yu, monocytes contribute to activation of monocytes of patients S-Y. Baek, S-M. Yoo, K-W. Seo and K-S. Kang. Kangstem with primary Sjogren¨ ’s syndrome. K. Yoshimoto, Y. Ikeda, Biotech, South Korea. K. Suzuki and T. Takeuchi. Keio Univ. Sch. of Med., Japan. P444 182.10 Endogenous antisense RNA and P458 182.24 Identification of T-cell subsets associated with dysregulation of CD39 expression in inflammatory bowel muscle strength in people with cancer: a pilot study. disease. M.S. Longhi, R. Harshe, A. Xie, H. Zhang, A. Narsale, R. Moya, J. Ma, L. Anderson, D. Wu, R.J. Robles, S. Mukherjee, M. Vuerich, A.C. Moss and J. Garcia and J.D. Davies. San Diego Biomed. Res. Inst. S.C. Robson. Beth Israel Deaconess Med. Ctr. and Univ. of Washington. P445 182.11 An autoimmune disease risk SNP, rs2281808, P459 182.25 Mitochondrial changes synergize with long- in SIRPG is associated with reduced expression of SIRPg and chain fatty acid derivatives to support Th17 inflammation in heightened effector state in human CD8 T-cells. S. Sinha. diabetes. M. Agrawal, D.A. Nicholas, E.A. Proctor, Univ. of Iowa. A.C. Belkina, A. Jones, L. Panneerseelan-Bharath, P446 182.12 Effect of an anti-inflammation treatment on F. Raval, B. Ip, M. Zhu, J. Cacicedo, C. Habib, N. Sainz- ligature-induced experimental periodontitis. A. Hu, K. Pan Rueda, L. Persky, P.G. Sullivan, B.E. Corkey, and X. Han. Forsyth Inst. C.M. Apovian, P.A. Kern, D.A. Lauffenburger and P447 182.13 Reduced gravity contributes to neutrophil to B.S. Nikolajczyk. Univ. of Kentucky, Boston Univ. Sch. of lymphocyte ratio shifting and promotion of the oxidative Med., Pennsylvania State Univ., Merrimack Col. and stress response. A.M. Paul, S.D. Mhatre, Massachusetts Inst. of Technol. E. Cekanaviciute, A-S. Schreurs, C.G.T. Tahimic, P460 182.26 Sterile skin injury leads to neutrophil- R.K. Globus, B. Crucian and S. Bhattacharya. NASA associated kidney inflammation. S. Skopelja-Gardner, Ames Res. Ctr. J. Tai, P. Hermanson, X. Sun, L. Tanaka and K.B. Elkon. P448 182.14 Reduced acetylation of histones H3 in Univ. of Washington. peripheral blood mononuclear cells of patients with Primary P461 182.27 Impact of genetic polymorphisms on human Sjogren¨ ’s syndrome. Y. Li. The First Affiliated Hosp. of Xiamen immune cell gene expression. B.J. Schmiedel, D. Singh, Univ., China. A. Madrigal, A.G. Valdovino-Gonzalez, B.M. White, P449 182.15 Stress-induced immune dysregulation: a J. Zapardiel-Gonzalo, B. Ha, G. Altay, J.A. Greenbaum, continuum spanning Antarctica winterover, spaceflight, and G. McVicker, G. Seumois, A. Rao, M. Kronenberg, terrestrial patients. S.S. Krieger, G. Makedonas, S. Mehta, B. Peters and P. Vijayanand. La Jolla Inst. for Immunology M. Nelman, D. Pierson, S. Tyring, A. Chouker,` and The Salk Inst. for Biol. Studies. M. Feuerecker, C. Strewe, C. Sams and B. Crucian. KBRwyle, JES Tech, NASA Johnson Space Center, Univ. of Texas Hlth. Sci. Ctr., Houston and Ludwig Maximilians Univ. of Munich, Germany.

99 SUNDAY—POSTER SESSIONS

P462 182.28 Functional characterization of an activating P474 182.39 Human herpes virus 6 may facilitate human anti-TLR4 monoclonal antibody (UT18) with a demonstrated endogenous retrovirus activation and endoplasmic reticulum role in reversal of new-onset type I diabetes in NOD mice. stress in de novo autoimmune hepatitis. U.D. Ekong, J. Yao, K.C.S. Locker, K. Hoebe, W.M. Ridgway and A.B. Herr. J. Patterson, Y. Avitzur, M. Martinez, S. Lobritto and Univ. of Cincinnati and Cincinnati Children’s Hosp. Med. Ctr. A.L. Mason. Yale Univ. Sch. of Med., Univ. of Alberta, P464 182.29 Alpha2B-adrenergic receptor regulates Canada, Hosp. for Sick Children, Canada and Columbia neutrophil recruitment in MSU-induced peritoneal Univ. Med. Ctr. inflammation. Y. Wei, L. Duan, J. Chen, X. Rao, Y. Tao P475 182.40 Increased expression of CD40 and CD40L in and J. Zhong. Case Western Reserve Univ., Oregon Hlth. acute coronary syndrome patients: association with genetic and Sci. Univ. and The First Affiliated Hospital of Xiamen Univ. variants in western Mexican population. D.E. Martinez- P465 182.30 Newfound role for noncanonical NF-kB Fernandez, J.R. Padilla-Gutierrez,´ F. Casillas-Muñoz, signaling in inflammatory bowel disease: gene expression E. Valdes-Alvarado,´ B. Parra-Reyna, M. Aceves-Ram´ırez, levels serve as a proxy for predicting anti-TNF therapy J.F. Muñoz-Valle and Y. Valle-Delgadillo. Univ. De responsiveness. H. Morrison, K. Eden, V.Q. Nguyen, Guadalajara, Centro Universitario de Ciencias de la Salud, D.R. Sorrentino, R.M. Brock and I.C. Allen. Virginia Mexico. Polytechnic Inst. and State Univ. and Virginia Tech Carilion P476 182.41 The Th2 cytokine IL-4 mediates loss of skin Sch. of Med. and Res. Inst. gdT cells in atopic dermatitis. J. Wang, Y. Fu and M.H. Kaplan. P466 182.31 Simultaneous analysis of gene expression and Indiana Univ. Sch. of Med. T cell repertoire in peripheral blood mononuclear cells from P477 182.42 Novel roles of lipid mediators in psoriatic skin patients with cystic fibrosis at the single cell level. inflammation. H. Sumida, Y. Kita, T. Shimizu and S. Sato. A. Ferguson, J. Luo, X. An, J.M. Pilewski, W. Chen and Univ. of Tokyo, Japan and Natl. Ctr. for Global Hlth. and Med., K. Chen. Univ. of Pennsylvania and Univ. of Pittsburgh Sch. of Japan. Med. P478 182.43 Enhanced adenosinergic signaling and P467 182.32 22q11.2 Deletion syndrome (DiGeorge) and immune cell exhaustion after trauma. S. Tiwari-Heckler, mutations in Forkhead Box N1 (FOXN1) cause a thymic M.S. Longhi, J. Harbison, L.E. Otterbein, C.J. Hauser hypoplasia through distinct developmental processes. and S.C. Robson. Beth Israel Deaconess Med. Ctr. and N.S. van Oers, Q. Du, L. Huynh, F. Coskun, I. Dozmorov, Harvard Med. Sch. P. Raj, S. Khan, C. Wysocki, M.L. Markert and M.T. de la P479 182.44 ATP release drives heightened immune Morena. Univ. of Texas Southwestern Med. Ctr., UT response and autoimmunity in hypertension. T. Zhao, Y. Li, Southwestern Med. Ctr., Duke Univ. Med. Ctr. and Univ. of K. Bernstein and X. Shen. Zhejiang Univ. Sch. of Med., China Washington. and Cedars-Sinai Med. Ctr. P468 182.33 Small intestinal lamina propria immune cells P700 182.45 Peripheral blood Th40 cells reflect disease dyshomeostasis is associated with alcoholic steatohepatitis in progression and are controlled by rituximab in human the mouse. L. Hao, W. Zhong, X. Sun and Z. Zhou. Univ. of multiple sclerosis. D.H. Wagner, G. Vaitaitis and D. Waid. North Carolina, Greensboro. Univ. of Colorado. P469 182.34 Idiopathic inflammatory myopathy patients with P701 182.46 Role of CD137L in lumbar spinal cord different autoantibody exhibit unique peripheral blood T cell microglial cytokine responses following sciatic nerve crush. subsets. J-P. Li, S-H. Chang, G.J. Tsay, D-Y. Chen and L. Cao. Univ. of New England. J-L. Lan. China Med. Univ. Hosp., Taiwan. P702 182.47 IL-35+ regulatory immune cells in diabetic P470 182.35 Age associated insulin resistance is controlled nephropathy. K. Singh, Z. Luo, P-O. Carlsson, P. Hansell by microbiota through a monocyte-B1a cell pathway. and S. Sandler. Uppsala Univ. and Uppsala Univ., Sweden. M. Bodogai, J. O’Connell, Y. Kim, J. Egan and P703 182.48 The unfolded protein response contributes to A. Biragyn. NIA, NIH. antiproliferative and proapoptotic effects of IFN-l4 in human P471 182.36 Identification of peripheral immune hepatic cells. O.O. Onabajo, F. Wang, O. Florez-Vargas, mechanisms playing a protective role in Alzheimer’s disease A. Obajemu, J. Vargas and L. Prokunina-Olsson. NCI, NIH. progression. A. Agrawal, J. Baulch, M. Acharya and P704 182.49 Nerve growth factor receptor expression marks S. Agrawal. Univ. of California, Irvine. activated human perivascular adventitial fibroblasts in distinct P472 182.37 Pro-fibrotic activation of human macrophages perturbed states. A.M.S. Barron, J.D. Ho, J.C. Mantero, in systemic sclerosis. R. Bhandari, M. Ball, V. Martyanov, J. Bhawan and J.L. Browning. Boston Univ. Sch. of Med. D. Popovich, E. Schaafsma, S. Han, M. Eltanbouly, P705 182.50 Monocytes of chronic fatigue syndrome M. Carns, E. Arroyo, K. Aren, M. Hinchcliff, M. Whitfield patients, their family members without CFS, and unrelated and P. Pioli. Dartmouth Geisel Sch. of Med. and Feinberg Sch. healthy donors: searching for differences. D. Hudig, of Med., Northwestern Univ. K. Tokunaga, A.P. Sung, M.J. Guglielmo, J. Smith- P473 182.38 The impact of IL-27 on human T cells is altered Gagen, R. Merica and D. Redelman. Sch. of Med., Univ. of in multiple sclerosis patients. M-L. Clenet,´ C. Laurent, Nevada, Reno. O. Devergne, P. Duquette, A. Prat, C. Larochelle and P707 182.51 Dysregulated monocyte compartment in N. Arbour. Centre de recherche du CHUM, Canada and human obesity. K. Friedrich, M. Sommer, S. Thrum, INSERM U1151, France. M. Bluher,¨ U. Wagner and M. Rossol. Leipzig Univ., Germany. P708 182.52 The effects of altered TGFb signaling on human T follicular helper cell development and function. Z.C. Schmiechen, K. Weissler, K. Laky and P. Guerrerio. NIAID, NIH.

100 SUNDAY—POSTER SESSIONS

P709 182.53 Kinetics of immune cell responses in the P722 182.66 IL-15 expression on B cells and myeloid cells is multiple low dose streptozotocin mouse model of type 1 distinctly modulated by inflammatory factors in MS and healthy diabetes. Z. Luo, C. Solang,¨ M. Blixt, P-O. Carlsson, donors. N. Farzam-kia, A. Carmena Moratalla, F. Lemaˆıtre, S. Sandler and K. Singh. Uppsala Univ., Sweden. D. Beauseigle, E. Haddad, C. Larochelle, A. Prat and P710 182.54 Glucocorticoid induced leucine zipper is N. Arbour. Centre de Recherche du Centre Hospitalier de inversely related with neuroinflammation in the brain. l’universite´ de Montreal,´ Canada and Fac. of Med., Universite´ N.M. Lynch, J. Wong and M. Srinivasan. Indiana Univ., de Montreal,´ Canada. Purdue Univ. Indianapolis. P723 182.67 NSG mice engrafted with human PBMC P711 182.55 Adaptive immune cell activation in acute provide a robust platform for preclinical testing of pediatric traumatic brain injury. S.B. Ortega, V.O. Torres, immunomodulatory therapeutics relevant to GvHD, F. Tian, K. Poinsatte, J. Tweed, C. Greenwell, autoimmunity, and oncology. B. Soper, A. Rose, A. Hodel J. Windsor, L. Raman, D. Miles and A. Stowe. Univ. of and P. Kaur. The Jackson Lab. Iowa, Univ. of Texas Southwestern Med. Ctr., Univ. of P724 182.68 BeO-exposure induces B cell-mediated Texas Arlington, Children’s Hlth. and Univ. of Kentucky. noninfectious granuloma formation in the lung. S.M. Atif, P712 182.56 Biochemical and functional characterization of D. Mack, A.S. McKee, J. Rangel-Moreno, A.K. Martin, the ICOSL TNFR2 interaction. N.G. Herrera, S. Garrett- A. Getahun, L.A. Maier, J.C. Cambier, R.M. Tuder and Thomson and S. Almo. Albert Einstein Col. of Med. A.P. Fontenot. Univ. of Colorado Anschutz Med. Campus, P713 182.57 CD4+ T cell antigen discovery in sarcoidosis. Univ. of Rochester Med. Ctr. and Dept. of Med., Natl. Jewish S.A. Greaves, A. Mitchell, M. Falta, R. Santos, C.A. Pinilla Hlth. and A.P. Fontenot. Univ. of Colorado Anschutz Med. Campus P725 182.69 Coronary artery bypass grafting surgery is and Torrey Pines Inst. for Molec. Studies. associated with immunoparalysis of monocytes and dendritic P714 182.58 Anti-inflammatory effects of xanthohumol in cells. A.J. Perros, A. Esguerra-Lallen, K. Rooks, S RAW 264.7 macrophages are mediated through the F.N. Chong, S. Engkilde-Pedersen, H.M. Faddy, U activation of AMP kinase. D.M. Mills, J. Samuels, E. Hewlett, R. Naidoo, J-P. Tung, J.F. Fraser, P. Tesar, N M. Hawkins, A. Gavre, R. Shashidharamurthy and M. Ziegenfuss, S. Smith, D. O’Brien, R.L. Flower and S. Rayalam. Philadelphia Col. of Osteo. Med. M.M. Dean. Australian Red Cross Blood Service, Australia P715 182.59 FcgRIIB on CD11c+ cells alters liver and and The Prince Charles Hosp., Australia. adipose tissue inflammation affecting glucose tolerance and P726 182.70 A Toll-like receptor 5 agonist entolimod atherosclerosis in female mice. J. Marvin, J.A. Balsamo, mitigates radiation damage through a neutrophil-dependent J.P. Rhoads and A.S. Major. Vanderbilt Univ. Med. Ctr. mechanism. C.M. Brackett, K. Greene, B. Kandar, P716 182.60 Correlating epigenetic modulating enzyme N. Trageser, R. Kandefer, S. Pal, L. Burdelya and PRMT5 to disease severity in multiple sclerosis. W. Osman, A. Gudkov. Roswell Park Cancer Inst. S. Amici, L. Webb and M. Guerau-De-Arellano. The Ohio P727 182.71 Differential activation of an innate immune State Univ. signaling pathway in lymphocytes from patients with multiple P717 182.61 Characterisation of immune complexes in sclerosis. M.D. Carrithers. Univ. of Illinois-Chicago. Kawasaki disease and other infectious diseases by protein P728 182.72 Detection and characterization of T cells sequencing. S. Menikou, A. McArdle, M. Kaforou, reactive to hybrid insulin peptides in patients with type 1 C. Shimizu, V.J. Wright, J.A. Herberg, J.T. Kanegaye, diabetes. R.L. Baker, P.A. Gottlieb, T. Delong and A. Tremoulet, J.C. Burns and M. Levin. Imperial Col. K. Haskins. Univ. of Colorado Sch. of Med. and Univ. of London, Univ. of California, San Diego and Rady Children’s Colorado, Skaggs Sch. of Pharmacy and Pharmaceutical Sci. Hosp. P730 182.73 Th1/Th2 imbalance in pregnant patients with P718 182.62 IL-15-driven clonal expansion of TLR9-primed antiphospholipid syndrome-related recurrent pregnancy loss is human B-CLL is characterized by activation of AKT and corrected by heparin and aspirin combination therapy. STAT5, downstream elevation of cyclin D2 and repression M. Wang, G. Zhou, J. Lv, T. Ishikawa, D. Nallapothula, of DNA damage response mediators, ATM and TP53BP. Q. Wang and R.R. Singh. Peking Univ. Shenzhen Hosp., P.K.A. Mongini, R. Gupta, S.L. Allen, J. Barrientos, Peking Univ. Shenzhen Hosp., China and David Geffen Sch. of J.E. Kolitz, K. Rai and N. Chiorazzi. Northwell Hlth., Med., Univ. of California, Los Angeles. Feinstein Inst. for Med. Res. and Northwell Hlth., Hofstra P731 182.74 The indispensable role of polarized abT17 cell Northwell Sch. of Med. in mannan-induced psoriasis model uncovers a novel P719 182.63 Early treatment of a CD137L neutralizing pathogenesis mechanism of psoriasis. H. Zheng, H. Zhou, antibody decreases mechanical hypersensitivity and X. Liu, X. Wei, X. Teng, Z. Wang, F.L. Zeng and J. Li. Sichuan functional recovery time following a sciatic nerve crush. Univ., China. A.A. Wakley and L. Cao. Univ. of New England. P732 182.75 Sexual dimorphism in the physiological P720 182.64 Mathematica as a tool for interactive display of response of the Apoe-/-atherosclerosis model to sleep flow cytometry and clinical data. A.I. Loewendorf, fragmentation. A.K. Moriarty, T. Waseem, W.C. Keeter, A.Y. Collier, D.A. Kahn, J. Nevell and T.A. Nguyen. S. Edemobi, M. Pham, L. Sanford, L. Wellman and ImmunoVation, Beth Israel Deaconess Med. Ctr. & Harvard E. Galkina. Eastern Virginia Med. Sch. Med. Sch., Asante Physician Partners, Medford, Oregon, P733 182.76 Plasmacytoid dendritic cells contribute to pro- Glendale, CA and David Geffen Sch. of Med., Univ. of inflammatory and pro-fibrotic milieu in lung fibrosis. R.R. Singh California, Los Angeles. and I. Valera. David Geffen Sch. of Med., Univ. of California, P721 182.65 Long-range cis-regulatory architecture of the Los Angeles. human IL2 gene. P.K. Sharma, R.M. Thomas, M. Johnson and A. Wells. The Children’s Hosp. of Philadelphia.

101 SUNDAY—POSTER SESSIONS

P734 182.77 High affinity autoantibodies to interferon-g from P463 182.89 Chronic inflammation associated with obesity the patients with adult-onset immunodeficiency. C-L. KU. exacerbates bone loss in mice. T. Fields, M. Ramanan, Chang Gung Univ. S. Rayalam and R. Shashidharamurthy. Philadelphia Col. P729 182.78 Construction of humanized mice, kinetics of of Osteo. Med. human immune system development and induction of T- dependent and T-independent antibody responses. 183. INFLAMMATORY AND AUTOIMMUNE DISEASE D.P. Chupp, O. Acosta, H. Zan and P. Casali. Univ. of Texas Hlth. at San Antonio. Poster Session P735 182.79 Symphony of life: genetics, immunology, SUN. 2:30 PM—EXHIBIT/POSTER HALL cancer & aging I. Genetic and immunological evaluation of mice with histocompatible tumors, virus induced breast cancer P744 183.1 Galectin-3 promotes non-canonical fl and survivors of metastatic breast cancer, HIV infection, and in ammasome activation through binding to glycans on LPS old people. R.M. Williams, J. Zuniga, R.M. Williams, intracellularly. T-H. Lo, H-L. Chen, H-Y. Chen and F-T. Liu. J. Granados, E.T. Feris and E.J. Yunis. Northern Academia Sinica, Taiwan. California Res. Inst., Dartmouth Geisel Sch. of Med., P745 183.2 Mature tissue-resident memory T cells lose the fl Northern California Cancer Ctr. & Res. Inst., Inst. of responsiveness to bystander in ammation. W. Liao and Nutrition, Mexico and Dana Farber Cancer Inst., Harvard N. Zhang. Univ. of Texas Hlth. Sci. Ctr., San Antonio. Med. Sch. P746 183.3 Prevention of erythrocyte fragility and anemia P736 182.80 Group A streptococcal infection, acute induced by extracellular histones. F. Kordbacheh, ’ rheumatic fever and rheumatic heart disease in the Solomon C.H. O Meara, L.A. Coupland, P.M. Lelliott and Islands. D. Sika-Paotonu and U. Liligeto. Wellington Sch. of C.R. Parish. The John Curtin Sch. of Med. Res., Australian Med. & Hlth. Sci., Univ. of Otago, New Zealand and Victoria Natl. Univ., Australia. Univ. of Wellington, New Zealand. P747 183.4 AhR ligands differentially affect thymus and P737 182.81 Functional studies to understand immune peripheral lymphoid organs by targeting T cells and their fl modifiers in cystic fibrosis. S. Lu, K. Song, J. Bomberger functions leading to pro- or anti-in ammatory responses. and J.K. Kolls. Tulane Univ. Sch. of Med. and Univ. of N.P. Singh, K. Miranda, D. Jackson, S. Sumpter, Pittsburgh. U.P. Singh, M. Nagarkatti and P. Nagarkatti. Univ. of P738 182.82 Vagal control of glycemia and inflammation in South Carolina Sch. of Med. diabetic septic mice. A. Mahmood, B. Joseph, G. Shimojo, P748 183.5 Roles of Toll-like receptors in regulating fi Z. Li, R. Shah, A. Kanashiro, H.C. Salgado and L. Ulloa. broblastic reticular cell pathobiology during sepsis. Rutgers New Jersey Med. Sch. and Univ. of Sao Paulo, Brazil. M. Deng, Y. Li, T. Chen, K. Chen and T.R. Billiar. Univ. of P739 182.83 Pulmonary eosinophilic granulomatosis with Pittsburgh. polyangiitis has allergic and immunoregulatory features. P749 183.6 Astragaloside IV, the major bioactive E. Lin, Z. Dong, M. Wechsler, M. Yandell and F. Clayton. component of Astragalus membranaceus (Fisch.) Radix, fl Univ. of Utah Sch. of Med. and Natl. Jewish Hlth. attenuates airway in ammation by modulating Th2 P740 182.84 Development of an outbred disease model of cytokines, STAT6 and ROR-gt transcription factors in an Hermansky-Pudlak syndrome in threespine stickleback. asthmatic mouse model. C-B. Shen, Y-N. Gu, S. Wang and E.A. Beck, M.C. Currey, E. Niebergall, S. Bassham and L. Yu. Shanghai TCM-Integrated Hosp., China. fi W.A. Cresko. Univ. of Oregon. P750 183.7 PGD2/DP1 signaling de ciency ameliorates P742 182.85 Epitope profiling of plasma antibody in experimental autoimmune encephalitis. J. Zheng and Alzheimer’s disease dementia patients. S-G. Park, S. Perlman. Carver Col. of Med., Univ. of Iowa. K.Y. Sim, Y. Byeon and K.H. Lee. Gwangju Inst. of Sci. P751 183.8 Histamine-releasing factor is a novel alarmin. and Technol., South Korea and Chosun Univ., South Korea. K. Kasakura, Y. Kawakami, Y. Kawakami and T. Kawakami. P743 182.86 Unraveling the role of fibrosis in the TB La Jolla Inst. for Allergy and Immunology. granuloma. S. Evans, E.A. Wong, J.L. Flynn, J.T. Mattila P752 183.9 Assessment of SALSA protein levels and its and D. Kirschner. Univ. of Michigan, Univ. of Pittsburgh and methylation status in healthy Indian individuals. M. Gandhi Univ. of Pittsburgh Grad. Sch. of Publ. Hlth. and K. Chaudhary. Guru Gobind Singh Indraprastha Univ., P706 182.87 BET bromodomain targeting suppresses the India. PD-1/PD-L1 pathway in triple-negative breast cancer and P753 183.10 REV-ERB-mediated regulation of dendritic cell elicits anti-tumor immune response. G. Andrieu, maturation and function. M. Amir, S. Campbell, J.S. Shafran and G.V. Denis. Institut Necker, Enfants T. Kamenecka and L.A. Solt. Scripps Florida. Malades, France and Boston Univ. Sch. of Med. P754 183.11 The effect of bee venom phospholipase A2 on P741 182.88 A phase 1, randomized, controlled clinical high-fat-diet-induced obesity in mice. H. Jeong, H. Lee and study of CC-11050 in people living with HIV with H. Bae. Kyung Hee Univ., South Korea. fl suppressed plasma viremia on antiretroviral therapy P755 183.12 Glycolytic regulation of neuroin ammatory (APHRODITE). A. Boulougoura, E. Gabriel, E. Laidlaw, response: role of monocarboxylate transporter 4. S. Giri, V. Khetani, K. Arakawa, J. Higgins, A. Rupert, J. Singh, H. Suhail, A. Kumar and R. Rattan. Henry Ford R.J. Gorelick, K. Lumbard, A. Pau, A. Poole, A. Kibiy, Hlth. Sys. and Wayne State Univ. Sch. of Med. P. Kumar and I. Sereti. NIAID, NIH, Karolinska Inst., P756 183.13 CD40 function in immune development and Sweden, Celgene Global Hlth., Celgene Corp., Frederick response: cell-type requirements and cytoplasmic domain Natl. Lab. for Cancer Res. and Georgetown Univ. Hosp. function. Y. Lu, J. Chiang, R. Zhang, F. Alkhaleel and R.J. Hodes. NCI, NIH and NIA, NIH.

102 SUNDAY—POSTER SESSIONS

P757 183.14 Upregulation of endocannabinoids in fatty acid P768 184.4 GTPase-activating protein (RASAL1) amide hydrolase knockout mice prevents staphylococcal associates with ZAP-70 of the TCR and negatively regulates enterotoxin B-mediated acute lung injury through changes in T cell proliferation and anti-tumor immunity. C.E. Rudd, the microbiome, immune, and metabolic profiles. M.A. Sultan, Y.R. Thaker, M. Raab and K. Strebhardt. Univ. de P. Nagarkatti and M. Nagarkatti. Sch. of Med., Univ. of South Montreal, Canada, Univ. of Essex, United Kingdom, J.W. Carolina. Goethe Univ., Germany and W.T. Goethe Univ., Germany. P758 183.15 Single-step purification of sputum extracellular P769 184.5 FOXP3, CD48, and autophagy confer the vesicles from cystic fibrosis patients using aF4-MALS. protection of CD4 and CD8 human T cells from T cell B. Dobosh, S. Liu, M. Chen and R.M. Tirouvanziam. receptor restimulation-induced cell death. K. Voss, Emory Univ. and Wyatt Tech. N.M. Lott, C. Lake, B.M. Bauman, B. Dorjbal, P759 183.16 Anti-CD11b antibody treatment suppresses C.R. Luthers, S. Arjunaraja, C.L. Dalgard and A.L. Snow. the disease conditions in rheumatoid arthritis-prone, Uniformed Serv. Univ. of the Hlth. Sci. FcgRIIB-deficient mice. K. Takahashi, M. Ohtsuji, Q. Lin, P770 184.6 The phosphorylation kinetics of the key H. Okazaki, H. Amano, H. Yagita, H. Nishimura and regulators in T cell receptor signaling pathway. W. An, S. Hirose. Kanagawa Univ. of Human Services, Fac. of K. Park, A. Reyes, A. Kwieraga, N. Sabri, A. Frey, Hlth. and Social Services, Japan, Toin Univ. of Yokohama, E. Chronopoulou, J. Savas-Carstens, D. Soper, J. Elia, Japan, Musashigaoka Junr. Coll., Japan and Juntendo Univ. M. Li and X. Yang. BioLegend, Inc. Sch. of Med., Japan. P771 184.7 TMEM16F regulates bystander TCR-CD3 P760 183.17 Leukotriene B4 is required for inflammasome membrane binding at the immunological synapse. activation. A. Salina, S. Brandt, A.I. Medeiros and A. Connolly, R. Panes,` A. Bellemare-Pelletier and H. Serezani. Vanderbilt Univ. Med. Ctr. and Sao Paulo E. Gagnon. Univ. of Montreal, Canada. State Univ. P772 184.8 PAK6: a novel kinase in the maintenance of S P761 183.18 Method development for the analysis of T cell anergy. A. Torres, A. Tang, R. Vyas, C. Su, M. Johnson U ’ PBMC-mediated killing of K562 cells by bovine colostrum and A. Wells. Children s Hosp. of Philadelphia and Univ. of N and various fractions. P.D. Vieira-Brock, A. Andersen, Pennsylvania. B. Vaughan and D. Vollmer. 4Life. P773 184.9 JNK inhibition by transforming growth factor-b P762 183.19 Brain-Thymus communication is a novel type I receptor (TGF-b RI) in T cells. R. Jacks and immunosuppressive feature of neurological insults. M. Iwashima. Loyola Univ. Chicago. K. Ayasoufi, C.K. Pfaller, R.H. Khadka, F. Jin and P774 184.10 TCR-pMHC bond length controls TCR ligand A.J. Johnson. Mayo Clin., Mayo Clin. Grad. Sch. of discrimination. J. Huang and D.K. Sasmal. Univ. of Chicago. Biomed. Sci. and Mayo Clin., Rochester, Minnesota. P775 184.11 T cell receptor-induced PLC-g1 sumoylation P763 183.20 A role for group 2 innate lymphoid cells in via PIASxb and PIAS3 SUMO E3 ligases regulates the muscular dystrophy. J. Kastenschmidt. Univ. of California, microcluster assembly and physiological function of PLC-g1. Irvine. Y. Li, J-Q. Liang and Q-L. Wang. Sun Yat-sen Univ., China. P764 183.21 Keratinocyte-derived CCL20 orchestrates epidermal localization of IL-17-producing gd T cells and 185. INNATE CELLS IN ANTI-PATHOGEN AND ILCs to mediate psoriasis-like skin inflammation. T.P. Singh, CYTOKINE RESPONSES X. Lu, S.P. Singh, H. Zhang, M. Doucet, S.L. Kominsky and J.M. Farber. NIAID, NIH and Johns Hopkins Univ. Sch. of Med. Poster Session SUN. 2:30 PM—EXHIBIT/POSTER HALL 184. T CELL RECEPTOR SIGNALING P776 185.1 Genome-wide analysis identifies pairs of cis- Poster Session acting lncRNAs and protein-coding genes involved in innate immunity. Q. Zhang, T-C. Chao, V.S. Patil, Y. Qin, SUN. 2:30 PM—EXHIBIT/POSTER HALL S.K. Tiwari, J. Chiou, A. Dobin, C-M. Tsai, Z. Li, J. Dang, P765 184.1 Recruitment of NEMO/IKKg to TCR S. Gupta, K.B. Urdahl, V. Nizet, T.R. Gingeras, K.J. Gaulton microclusters during T cell activation. N.R. Koylass, and T.M. Rana. Univ. of California, San Diego Sch. of Med., E.A. DeRiso, A.L. Szymczak-Workman, A. Montecalvo, Cold Spring Harbor Lab. and Univ. of Washington Sch. of Med. J.M. Murphy, M. Cristina Seminario, L.P. Kane and P777 185.2 PD-L2 generates a signal through the PD-1 co- S.C. Bunnell. Tufts Univ. Sch. of Med. and Univ. of receptor distinct from that of PD-L1. A. Srinivasamani, Q. Liu Pittsburgh Sch. of Med. and M. Curran. Univ. of Texas MD Anderson Cancer Ctr. P766 184.2 Engagement of CD45 differentially alters early P778 185.3 Regulatory role of Ifit2 in mouse hepatitis virus signaling events in human T cells costimulated through TCR+ induced neuroinflammation. J. Das Sarma, A. Burrows, CD28 compared with TCR+ICAM-1. A. Bhatta, M. Chan and P. Kessler, M-H. Hwang, C. Bergmann and G.C. Sen. S.H.O. Benedict. Univ. of Kansas. Indian Inst. of Sci. Educ. and Res., India and Cleveland Clin. P767 184.3 Molec. background of Orai1 accumulation in P800 185.4 Indole-3-carbinol ameliorates colonic the immunological synapse. O. Vor¨ os,¨ G. Panyi and P. Hajdu. inflammation in DSS-treated, Helicobacter muridarum- Fac. of Med., Univ. of Debrecen, Hungary and Fac. of infected mice. R.R. Alkarkoushi, U.P. Singh, Dentistry, Univ. of Debrecen, Hungary. I. Chatzistamou, M. Bam, Y. Hui, M. Nagarkatti, P. Nagarkatti and T.L. Testerman. Univ. of South Carolina Sch. of Med.

103 SUNDAY—POSTER SESSIONS

P806 185.5 MiR-146a is a negative regulator of IL-33- 186. MOLECULAR CONTROL OF CD4+ T CELL LIFE stimulated mouse mast cells. S.A. Kee, M.T. Taruselli, CYCLE: ACTIVATION, EFFECTOR J.J. Ryan and A. Abdul Qayum. Virginia Commonwealth AND MEMORY Univ. P807 185.6 Cannabinoid receptor 1 blockade attenuates Poster Session fl obesity and adipose tissue type 1 in ammation through miR- SUN. 2:30 PM—EXHIBIT/POSTER HALL 30e-5p regulation of Delta-like-4. K. Miranda, P. Mehrpouya- Bahrami, P.S. Nagarkatti and M. Nagarkatti. Univ. of South P812 186.1 Using single-cell RNA-seq to lineage trace + Carolina Sch. of Med. effector to memory transitions in CD4 T cells during P810 185.7 Genomic analysis of bone marrow progenitors malaria. S.F.M. Soon, J. Engel, J. Lee, K. James, during viral infection reveals novel dendritic cell regulators. T. Lonnberg, V. Svensson, S. Teichmann and A. Haque. Y. Jo, K. Zhang, W. Wang and E. Zuniga. Univ. of California, QIMR Berghofer Med. Res. Inst., Australia, Wellcome Trust San Diego. Sanger Inst., Univ. of Turku, Finland and California Inst. of P779 185.8 Transcription factor Blimp-1 regulates Technol. fi sebocyte homeostasis and cytokine production. K-H. Hung, P813 186.2 Characterization and transcriptional pro ling of + Y-F. Wu and K-I. Lin. Academia Sinica, Taiwan. tissue-resident memory CD4 T cells. Q.P. Nguyen, T. Deng P801 185.9 Resistin-like molecule alpha dampens lung and A.W. Goldrath. Univ. of California, San Diego. inflammation and promotes wound healing in helminth P814 186.3 Transcription coactivator OCA-B mediates fi infection and a 3D lung repair model. SY. Kim, J. Li, interactions between target loci in T cells and is suf cient to A.C. Burr, H. Batugedara, T. Nordgren, X. Zang and promote CD4 memory in vivo. D.R. Tantin, K. Zhao, M.G. Nair. Univ. of California, Riverside and Albert Einstein M.A. Williams, J.S. Hale, B. Lai, G. Ren and H. Kim. Univ. Col. of Med. of Utah and NHLBI, NIH. P802 185.10 Autophagy ablation in adipocytes induces local P815 186.4 Plexin B1 expression on human Treg cells is inflammation, insulin-resistance and reveals roles for lipid required for regulation of their phenotypic stability by peroxide and Nrf2 signaling in adipose-liver crosstalk. semaphorin 4A. S.P. Chapoval, M. Hritzo, X. Qi, M. Ferhat, A. Achenbach, J. Cai, K.ScottM. Pires, L. Tamagnone, A. Golding and A.D. Keegan. Univ. of B. Chaurasia, M.A. Buffolo, R. Smalling, A. Sargsyan, Maryland Sch. of Med. and Univ. of Torino Med. Sch. D.L. Atkinson, S.A. Summers, T.E. Graham and P817 186.5 CCDC134 facilitates T cell activation and fl S. Boudina. Nutrition and Integrative Physiology and Univ. in ammatory responses by regulating T cell receptor of Utah Sch. of Med. signaling. J. Huang, T. Zhang, B. Yu, S. Yin and X. Qiu. P803 185.11 Identification and characterization of fish- Sch. of Basic Med. Sci., Peking Univ. Hlth. Sci. Ctr., China. fi specific IL-23 isoforms and their roles in fish immunity. P818 186.6 Identi cation of distinct highly pathogenic fi L. Qin, S. Zhang and H. Zhou. School of Life Sci. and allergen-speci c T cells in common allergy and asthma. Technol., Univ. of Electronic Sci. and Technol. of China, China. G. Seumois, C. Ramirez Suastegui, B.J. Shmiedel, P804 185.12 The biological function of naturally occurring S. Liang, V. Shulten, B. Panwar, A. Madrigal, A. Sette, DOCK2 inhibitor in tissue-specific immune evasion. B. Peters and P. Vijayanand. La Jolla Inst. for Immunology. T. Sakurai, T. Uruno and Y. Fukui. Kyushu Univ., Japan. P820 186.7 Inhibitory effects of Klotho hormone on fi + P805 185.13 Role of PAFR-MHC-II-CD38 interactions in antigen-speci c clonal expansion of CD4 T cells. H. Hwang infections. A.A. Khan. Univ. of Missouri, Columbia. and A.K. Bamezai. Villanova Univ. P808 185.14 microRNA-21 controls inflammatory and P821 186.8 The role of aquaporin-4 in T cell activation. metabolic program of macrophage and neutrophils during M. Nicosia, A.M. Beavers, G.W. Farr, P.R. McGuirk, sepsis. P.H. Melo, A.R. Piñeiros Alvarez and M. Pelletier and A. Valujskikh. Cleveland Clin. and C.H. Serezani. Vanderbilt Univ. Med. Ctr. and Indiana Univ. Aeromics LLC. Sch. of Med. P822 186.9 NF-kB/mTOR/MYC axis drives PRMT5 protein P809 185.15 CD73-dependent adenosine dampens IL-1b- induction after T cell activation. S. Sengupta, L. Webb, induced CXCL8 production in gingival fibroblasts via HO-1 and J. Narvaez-Miranda, S. Amici, G. Nagy and M. Guerau- pAMPK. E. Schnaider Ramos Junior, M. Pedram, R.E. Lee, De-Arellano. Col. of Med., The Ohio State Univ. and The D. Exstrom, O. Yilmaz, R. Coutinho-Silva, D.M. Ojcius and Ohio State Univ. A.C. Morandini. Univ. of the Pacific Arthur Dugoni Sch. of P824 186.10 Fibronectin costimulation of CD40L expression fl Dent., Med. Univ. of South Carolina and Federal Univ. of Rio de integrates innate and adaptive in ammatory signals. Janeiro, Brazil. J. Ragheb, Y. Zhang, N. Bushar, H. Oh, E.M. Gertz, P811 185.16 RNA-binding protein EWS, a novel modulator A. Patnaik, S. Chakrabarty, R. Kampen, A.D. Kirk, of LTbR signaling. R. Virgen-Slane, R.G. Correa, D. Roberts and A. Schaffer¨ . Ctr. for Drug Evaluation and P. Ramezani-Rad, A. Rosa-Campos, J. Li and C.F. Ware. Res., FDA and NIH. fi Sanford Burnham Prebys Med. Discovery Inst. and Boehringer P825 186.11 Th2 cytokines and speci c donor alloantigen + + Ingelheim Pharmaceuticals, Inc. activated CD4 CD25 T cells reverse chronic rejection: role of IL-4 and IL-5 in promoting antigen-specific Treg. B.M. Hall, P. Rakesh, G. Tran, R. Hall, S. Bedi, C.M. Robinson, The AAI Career Advisory Board A. Sharland, C. Wang, S.J. Hodgkinson and N.D. Verma. will be at the AAI Booth 1101, Univ. of New South Wales, Australia and Sydney Univ., Sunday, May 12, from 2:30 PM – 3:45 PM. Australia.

104 SUNDAY—POSTER SESSIONS

P826 186.12 The spatial and translational mechanisms that P837 187.8 MCMV-experienced ILC1 acquires an m12- govern TOX, a key regulator of lymphocyte development and dependent memory response. T.E. O’Sullivan, function. A. Yeckes, B. de la Torre, A. Kadavallore, O-E. Weizman, J.R. Carlyle and J.C-Y. Sun. David Geffen R. Murali, R. Soberman and J. Kaye. Cedars Sinai Med. Sch. of Med., Univ. of California, Los Angeles, Mem. Sloan Ctr. and Massachusetts Gen. Hosp. Kettering Cancer Ctr. and Univ. of Toronto. P827 186.13 The RNA binding protein HuR is required for P840 187.9 A role for allosteric disulfides in regulating the antigen-mediated activation and proliferation of CD4+T cells. function of human killer cell receptor KIR2DL4. J.S. Ellis, T. Taylor and U. Atasoy. Univ. of Michigan. S. Rajagopalan, G. Mastorakos and E.O. Long. LIG, P819 186.14 Elucidation of long non-coding RNA Snhg7 NIAID, NIH. functions in T cells. M. Varney, J. McCall, S. Westfall, P850 187.10 Suppression of Aiolos and Ikaros expression K. Blethen, I. Martinez and J.B. Barnett. West Virginia Univ. by lenalidomide reduces human ILC32ILC1/NK cell P823 186.15 Lymphopenia and bone marrow T cell transdifferentiation. L. Mazzurana, M. Forkel, A. Rao, sequestration accompanying stroke are mediated by T cell A. Van Acker, E. Kokkinou, T. Ichiya, S. Almer, C. Ho¨ og,¨ S1P1 loss. D.S. Wilkinson, C. Dechant, P. Chongsathidkiet, D. Friberg and J. Mjosberg¨ . Karolinska Inst., Sweden, H. Wang, H. Kemeny, D. Laskowitz and P. Fecci. Duke Univ. Karolinska Univ. Hosp., Sweden and Uppsala Univ., Sweden. Med. Ctr. P848 187.11 NF-kB-targeted intervention of P816 186.16 Activation-dependent posttranscriptional acetaminophen-induced acute liver injury by benzyl regulation of CD40L is required for an optimal germinal indanone. J.Y. Song, D-E. Jung, S-J. Jung, S-B. Han and center response. B. Narayanan, D. Prado De Maio, Y. Kim. Chungbuk Natl. Univ., South Korea and Chungnam K. Voskoboynik, J. La Porta, P. Xie and L.R. Covey. Natl. Univ., South Korea. Rutgers Univ. P849 187.12 Development of functional mannose binding P828 186.17 Hypoxia-inducible factors (HIF) in CD4+ T cells lectin is delayed in extremely low birth weight infants. S promote metabolism, switch cytokine secretion, and T cell help M.M. Dean, G.H. Lopez, H.G. Liley, S.L. Heatley and U in humoral immunity. S.H. Cho, A. Raybuck, E. Kemboi, R.M. Minchinton. Australian Red Cross Blood Service, N V. Haase and M.R. Boothby. Vanderbilt Univ. Med. Ctr. Australia, Mater Mothers’ Hosp., Australia, South Australian Hlth. and Med. Res. Inst., Australia and Central Queensland 187. REGULATORY MECHANISMS Univ., Australia. P851 187.13 A host-associated antimicrobial agent exhibits Poster Session both immunoprotective and immunotherapeutic effects. SUN. 2:30 PM—EXHIBIT/POSTER HALL M.E. Dawes, C. Xie and C.G. Chitko-McKown. Western Univ. of Hlth. Sci., Col. of Vet. Med. and US-Meat Animal P829 187.1 MAP kinase phosphatase (Mkp)-1 controls Res. Ctr., Clay Ctr., NE. program death-ligand (PD-L)1 expression during sepsis. P854 187.14 Alcohol effects on immune responses of S.G. Kirk, A.J. Batty, X. Wang, J. Li, W.M. White, classical pro-inflammatory macrophages. Y. Hu and W.E. Ackerman, L.D. Nelin, I. Buhimschi, M. Hafner and M. Yoshimura. Louisiana State Univ. ’ Y. Liu. Nationwide Children s Hosp. and NIH. P832 187.15 JUUL E-vapor has less protective effect in a P830 187.2 Dysregulation of lipid metabolism during gram- zebrafish model of heart failure compared to nicotine Salt, fi negative sepsis in Mkp-1 de cient mice. A.J. Batty, J. Li, nicotine agonists, and first-generation ENDS. X.K. Mai, X. Wang, W.E. Ackerman, S.G. Kirk, W.M. White, X. Wang, S. Chow, J. Cameron and S.A. O’Barr. Western Univ. of D. Anastasakis, L. Samavati, I. Buhimschi, L.D. Nelin, Hlth. Sci. Col. of Pharmacy and Western Univ. of Hlth. Sci. Col. ’ M. Hafner and Y. Liu. Nationwide Children s Hosp., NIAMS, of Optometry. NIH and Ctr. for Molec. Med. and Genet. P839 187.16 The role of the innate immune system in P847 187.3 Therapeutic effects of a phospholipase D1 doxorubicin-induced cardiotoxicity. A. Bhagat and inhibitor against polymicrobial sepsis. Y-S. Bae, S.K. Lee, E.S. Kleinerman. Univ. of Texas MD Anderson Cancer Ctr. Y.S. Kim and H.Y. Lee. Sungkyunkwan Univ., South Korea. P842 187.17 IL-1R signaling enhances neutrophil P844 187.4 Serum amyloid A promotes LPS clearance and extracellular traps formation and leads to increase lung attenuates LPS-induced tissue injury. R.D. Ye, N. Cheng, permeability and hypoxemia in LPS/mechanical ventilation- Y. Liang and X. Du. Chinese Univ. of Hong Kong, induced acute lung injury mouse model. N. Nosaka, Shenzhen, China and Univ. of Illinois, Chicago. C. Martinon, T.R. Crother, M. Arditi and K. Shimada. P835 187.5 MyD88 mediates the pathogenesis of Cedars-Sinai Med. Ctr. fi dermatitis in SHARPIN-de cient mice by regulating TNF P857 187.18 Bisphenol-A leads to overexpression of production on the skin. B.R. Sharma, R. Karki and estrogen receptors and diminishes protective chemokine T-D. Kanneganti. St. Jude Childrens Res. Hosp. responses in a zebrafish model. D. Walser-Kuntz, T. Tieu, P836 187.6 The ssDNA exonucleases PLD3 and PLD4 are T. Scott and P. Khan. Carleton Col. required to prevent lethal primary HLH-like disease in mice. P838 187.19 Developmental and environmental regulation A.L. Gavin, D. Huang and D. Nemazee. Scripps Res. Inst. of lung macrophage immune response. A. Yamamura, P846 187.7 Key roles for the innate immune response to S.J. Lund, O. Lakhdari, M. Sakai, C.K. Glass and genotoxic stress in neurological disease. J.R. Lukens, L.S. Prince. Univ. of California, San Diego. C.E. Bellinger, E.L. Frost, M.E. Shaw, A.C. Bolte and C.R. Lammert. Univ. of Virginia.

105 SUNDAY—POSTER SESSIONS

P833 187.20 ABCG1 deficiency in alveolar macrophage P861 187.33 Myeloid CFTR loss-of-function causes promotes multiwall carbon nanotube-induced pulmonary persistent neutrophilic inflammation in cystic fibrosis. granulomatous inflammation in mice. E. Soliman, G. Wang and H.P. Ng. Louisiana State Univ. Hlth. Sci. Ctr. M. McPeek, A. Malur, D.A. Tokarz, G. Murray, P862 187.34 NLRP12 regulates intestinal inflammation and K.M. Gowdy, C. Wingard, M. Fessler, B.P. Barna and tumorigenesis independent of gut microbiota. S. Khan and M.J. Thomassen. East Carolina Univ., North Carolina State H. Zaki. Univ. of Texas Southwestern Med. Ctr. Univ., Bellarmine Univ. and National Inst. of Envrn. Hlth. Sci. P863 187.35 Structure of human ferroportin (SLC40A1) P845 187.21 Deciphering liver environmental signaling inferred from mass spectrometry restraints. C. Parry, pathways for Kupffer cell identity. M. Sakai, T.D. Troutman, G. Vazquez-meves, A. Ivanov, X. Lin, N. Kumari and J.S. Seidman, Z. Ouyang, N.J. Spann, Y. Abe, K. Ego, S. Nekhai. Howard Univ. C.M. Bruni, J.C.M. Schlachetzki, A. Nott, H. Bennett, P864 187.36 Dynamic interaction of PSGL-1 with the T cell J. Chang, B.C.T. Vu, M. Pasillas, V.M. Link, L. Texari, receptor regulates the extent of T cell activation. D.C. Otero, S. Heinz and C.K. Glass. Univ. of California, San Diego. J. Ma and L. Bradley. Sanford Burnham Prebys Med. P852 187.22 The cholesterol transporter ABCG1 modulates Discovery Inst. macrophage polarization in human monocyte-derived macrophages. D. Sag, D. Unuvar Purcu and M. Altunay. 188. B CELLS AND THE CELLS THAT HELP Izmir Biomedicine and Genome Ctr., Hlth. Sci. Inst. Dokuz Eylul Univ. and Izmir International Biomedicine and Genome Poster Session Inst., Dokuz Eylul Univ. SUN. 2:30 PM—EXHIBIT/POSTER HALL P853 187.23 -2 isoforms regulate distinct functions of tumor-associated macrophages in breast P866 188.1 Protein kinase CK2 drives plasma cell cancer. A.C. Soloff, R.A. Stanton, N.M. Radio, M. Freilino- differentiation. H. Wei, W. Yang, Z. Yan, H. Qin and Glunt, C. Nasarre, A. Dimou, P. Nasarre, C.E. Denlinger, E. Benveniste. Univ. of Alabama at Birmingham. S. Oesterreich, A.V. Lee, M.T. Lotze, R. Dhupar and P875 188.2 IRF4 regulates the proliferative response R. Gemmill. Univ. of Pittsburgh, Med. Univ. of South during B cell differentiation in vivo. D. Patterson, Carolina, Thermo Fisher Scientific, Univ. of Colorado Sch. of C. Scharer, T. Mi, S.L. Hicks, Q. Zhang and J.M. Boss. Med. and UPMC Hillman Cancer Ctr. Emory Univ. Sch. of Med. and Emory Univ. Sch. of Publ. Hlth. P834 187.24 Regulatory roles of suppressors of cytokine P874 188.3 B cell activation and differentiation employ signaling 1 during type I vs type II macrophage polarization mTORC1 rather than Xbp1 to initiate distinct segments of and phenotype determination. C-E. Lee, H. Jeong and the unfolded protein response prior to antibody secretion. G-Y. Kim. Sungkyunkwan Univ. B.M. Gaudette, D.D. Jones, J.R. Wilmore and D. Allman. P855 187.25 miR-222 stimulates M2b macrophage Perelman Sch. of Med., Univ. of Pennsylvania. polarization in severely burned mice through the degradation P1200 188.4 E3 ubiquitin ligase Fbw7 regulates B cell of long noncoding RNA GAS5. I. Ito, C.C. Finnerty, survival and T cell-independent responses. P. Ramezani- D.N. Herndon, M. Kobayashi and F. Suzuki. Univ. of Rad, C.R. Leung, J.R. Apgar and R.C. Rickert. Sanford Texas Med. Br. Burnham Prebys Med. Discovery Inst. P841 187.26 Functional characterization of a novel myeloid P877 188.5 IL-21-dependent Tbet+ B cells require Bcl6 cell-specific lncRNA U90926. S. Sabikunnahar, S. Varnum, and receive delayed help from non-Tfh T cells. J.J. Bivona, R. Cooper and D. Krementsov. Univ. of R.C. Levack, M. Popescu and G. Winslow. Upstate Med. Vermont. Univ. P856 187.27 Trim33 plays an indispensable role in the P870 188.6 Extracellular ST6Gal-1 calibrates B cell IgG differentiation and functions of dendritic cells. production by cell non-autonomous extrinsic sialylation. C.V. Rathinam. Univ. of Maryland Sch. of Med. E.E. Irons, P.R. Punch and J.T.Y. Lau. Roswell Park P858 187.28 Chronic viral infection induces metabolic Cancer Inst. reprograming of plasmacytoid dendritic cells. T.T. Greene, P876 188.7 IL-12 signaling drives the differentiation and Y. Jo and E. Zuniga. Univ. of California, San Diego. function of a TH1-derived TFH1-like cell population. P831 187.29 Loss of miR-146a skews the dendritic cell M.D. Powell, K. Read, B. Sreekumar and K.J. Oestreich. milieu in favor of CD8a+CD103+ cross-presenting migratory Virginia Polytechnic Inst. and State Univ. and Biomed. and Vet. dendritic cells and reduces production of IL-27. P.A. Flynn and Sci. Grad. Program, Virginia-Maryland Col. of Vet. Med. E.F. Lind. Oregon Hlth. & Sci. Univ. P868 188.8 Investigating transcriptional regulators of P859 187.30 Protective effect of a brown algae, Sargassum memory T follicular helper cells. T. Deng, L. Shaw, B. Yu, horneri on particulate matter-induced oxidative stress and Q.P. Nguyen, S.M. Hedrick and A.W. Goldrath. Univ. of inflammation in MLE-12 cells. H.J. Kim, K.H.I.N.M. Herath, California, San Diego. A. Kim, S.P. Mihindukulasooriya, M. Ko, Y. Jeon, Y. Jee and P869 188.9 LSD1 epigenetically represses NF-kB target H.J. Kim. Jeju Natl. Univ. genes to regulate marginal zone B cell development. P860 187.31 Sargassum horneri inhibits particulate matter- R.R. Haines, C.D. Scharer and J. Boss. Emory Univ. induced apoptotic cell death in splenocytes. Y. Jee, A. Kim, P865 188.10 B cell recruitment to the intestine critically K.H.I.N.M. Herath, H.J. Kim, S.P. Mihindukulasooriya, depends on GATA3- and RORgt-mediated development of M-O. Ko and Y-J. Jeon. Jeju Natl. Univ. NKp46 negative innate lymphoid cells. M. Zheng, K. Mao, P843 187.32 Clinical manifestations following intramuscular D. Li, D. Fang, J. Lyu and J. Zhu. NIAID, NIH. exposure of mice to a lethal dose of ricin. A. Sapoznikov, R. Falach, Y. Gal, Y. Evgy, C. Kronman and T. Sabo. Israel Today, Sunday, May 12, is the last day to Inst. for Biological Res., Israel. attend an Exhibitor Workshop.

106 SUNDAY—POSTER SESSIONS

P879 188.11 The class II peptide editor, H2-M, affects the P1211 189.6 Themis integrates T cell receptor and cytokine development and function of B-1 cells. D. Ghosh, X. He, signals in CD8+ T cells. N.R.J. Gascoigne, J. Brzostek, M.E. O’Mara, A.B. Kantor, D. Sengupta, Y. Yang, X. Zhao, G. Fu, E.W. Chen and M. Mehta. Natl. Univ. of L.C. Eisenlohr, P.E. Jensen, L.A. Herzenberg and Singapore, Singapore and Xiamen Univ., China. E.D. Mellins. Stanford Univ. Sch. of Med., Univ. of Utah and P1210 189.7 Identity of recirculating T cells in humans. Perelman Sch. of Med., Univ. of Pennsylvania. M. Buggert, S. Nguyen, S. Darko, A. Ransier, D. Douek, P867 188.12 MALAT1 is essential for A-NHEJ pathway A. Bar-Or, N.K. Bjorkstr¨ om,¨ Y. Dori, M.G. Itkin and choice during B cell immunoglobulin class switch M.R. Betts. Karolinska Inst., Sweden, Perelman Sch. of recombination. J. Zhao, Y. Hu and J. Lin. Cleveland Clin. Med., Univ. of Pennsylvania, VRC, NIAID, NIH, Univ. of and Case Western Reserve Univ. Pennsylvania, Karolinska Inst., Karolinska Univ. Hosp., P871 188.13 Immune complexes gener+X6293ate PD1int Sweden and Children’s Hosp. of Philadelphia, Penn CD4+ T cells which are Bcl6+IFN-g+ unlike exhausted Medicine, Hospital of the Univ. of Pennsylvania. PD1high cells. A.K. Chauhan. Saint Louis Univ. P1217 189.8 STAT4 programs CD103- tissue-resident P872 188.14 The E3 ligase VHL promotes the differentiation memory cells during infection. T. Bergsbaken, H. Fung, of follicular helper T cells through glycolytic-epigenetic N. Wilson and M. Teryek. Rutgers New Jersey Med. Sch. pathways. Y. Zhu, Y. Zhao, D. Aki and Y-C. Liu. Sch. of P1205 189.9 Quantifying the tissue-resident immune Life Sci., Tsinghua Univ., China and Sch. of Med., Tsinghua system. S. Wijeyesinghe, L.K. Beura, J.M. Stolley, Univ., China. P.C. Rosato, M. Pierson and D. Masopust. Univ. of P873 188.15 H3K27me3-specific demethylases modulate B Minnesota. cell development and differentiation. A. Kania, C.D. Scharer, P1207 189.10 Hypoxia and TGF-b1 induce tissue resident M.J. Price, R.R. Haines, L-E. Alexander-George and memory phenotype cells from human peripheral blood J. Boss. Emory Univ. T cells in vitro. F. Hasan, R. Shaw, J. Wang and C. Yee. S P878 188.16 The role of the von-Hippel Lindau gene in Univ. of Texas MD Anderson Cancer Ctr. U fi osteocytes on B lymphocyte maturation and activation. P1215 189.11 TCR signal strength and antigen af nity N B.J. Chicana and J.O. Manilay. Univ. of California, Merced. independently modulate CD8+ memory T cell development. P1201 188.17 Activation of aryl hydrocarbon receptor with S. Solouki, A. August and W. Huang. Cornell Univ. structurally diverse ligands represses class switch to P1218 189.12 Long-lived effector CD8+ T cells are immunoglobulin A. A.B. Costa, A.L. Hirsch and transcriptionally and functionally distinct from effector G.K. DeKrey. Georgia Inst. of Technol. and Univ. of memory cells. H. Nguyen, C. Toma, K. Omilusik, Northern Colorado. A.W. Goldrath and J.J. Milner. Univ. of California, San Diego. P1202 188.18 Production of qualitatively different antibodies P1208 189.13 Dividing and non-dividing subsets of CD8 by T-bet+ IgM memory cells and plasmablasts. R.E. Lange, memory T cells differentially experience the homeostatic R. Levack, R. King and G. Winslow. Syracuse Univ., Upstate cytokines in the organs. K.H. Kim, U-H. Ha and Y.W. Jung. Med. Univ. and Univ. of Alabama, Birmingham. Korea Univ., South Korea. P1203 188.19 Elucidating the nature of long-lived plasma cell P1209 189.14 Distinct lymph node entry efficiencies for CD8+ precursors. G.K. Manakkat Vijay, A.S. Chawla and H. Singh. and CD4+ T cells are eliminated during malnourishment. Cincinnati Children’s Hosp. Med. Ctr. M.R. Gubbels Bupp, S. Goulmamine, D. Gibson, A. Little, S. Murphy, K. Patrick and T. Thoner. Randolph-Macon Col. 189. CD8+ T CELL HOMEOSTASIS AND MEMORY P1214 189.15 A single administration of Fc-fused recombinant human IL-7 induces expansions of T Poster Session lymphocytes in healthy adult volunteers. S. Kim, D-H. Choi, SUN. 2:30 PM—EXHIBIT/POSTER HALL M.K. Heo, B.H. Lee, S-H. Yang, Y.C. Sung, H. Lee, E-C. Shin and S-H. Park. KAIST, South Korea, NeoImmuneTech, Inc., P1206 189.1 Microbiota-derived butyrate promotes cellular Genexine, Inc., South Korea, Grad. Sch. of Convergence Sci. + metabolism and memory potential of antigen-activated CD8 and Tech., Seoul Natl. Univ., South Korea and Grad. Sch. of T cells. S. Bedoui, K. Binger, K. Kallies, S.J. Turner, Med. Sci. and Engin., KAIST, South Korea. M. McConville, T. Gebhardt and A. Bachem. Univ. of P1219 189.16 DOCK8 differentially regulates STAT3 and Melbourne, Australia. STAT5 nuclear translocation to maintain T-cell immune + P1216 189.2 Microbial exposure expands a Ly6C tolerance. S.S. Saha, A.K. Singh, A. Zielinska- subpopulation of long lived naive CD8 T cells with a rapid Kwiatkowska, G. Bhise, J. Woods and M. Oukaa. Seattle effector function via type I intereferons. M. Jergovic and Children’s Res. Inst. J. Nikolich-Zugich. Univ. of Arizona. P1220 189.17 Expression of a core gene module of anergy P1212 189.3 PRMT5-mediated arginine methylation governs maternal CD8+ T cell hypofunction after pregnancy. controls the strength of signaling via gc-family cytokines P. Porrett, R. Xu and E.J. Wherry. Perelman Sch. of Med., required for T cell maintenance. M. Inoue, K. Okamoto and Univ. of Pennsylvania. H. Takayanagi. Univ. of Toyko, Japan. P1221 189.18 Single cell multiomic analysis of chronically + P1213 189.4 STAT1 restrains peripheral naive CD8 T cell stimulated T cells displaying hallmarks of T-cell exhaustion. responsiveness to homeostatic cytokines by regulating M. Nakamoto, M. Corselli, I. Taylor and S. Saksena.BD mTORC1 signaling. Y-C. Kye, C-H. Yun and J-H. Cho. Biosciences and FlowJo, LLC. Acad. of Immunology and Microbiology, Inst. for Basic Sci., South Korea and Seoul Natl. Univ., South Korea. P1204 189.5 NFAT1 and NFAT2 differentially regulate CTL Have you completed and dropped off your Exhibit Hall Passport? differentiation upon acute viral infection. T. Xu, A. Keller and They are due today, Sunday, May 12, by 2 PM. Drawing at 3 PM! G.J. Martinez. Rosalind Franklin Univ. of Med. and Sci.

107 SUNDAY—POSTER SESSIONS

190. MICROBIAL, PARASITIC, AND P1248 190.13 Circulating memory is sufficient for protective FUNGAL IMMUNOLOGY immunity to secondary infection with Chlamydia. J.C. Labuda and S.J. McSorley. Univ. of California Davis. Poster Session P1249 190.14 Infiltrated monocyte and T-cell interaction SUN. 2:30 PM—EXHIBIT/POSTER HALL drives immunopathology in the brain during cryptococcal meningoencephalitis. J. Xu, M. Ivey, J. Koble, R. Lopez, P1223 190.1 Role of the microbiota in primary lung cancer C. Mechler, L. Neal, P. Williamson, B. Segal and initiation and progression. U.D. Rose, M. Vetizou, S. Roy, M.A. Olszewski. Univ. of Michigan Med. Sch. and NIAID. B. Edwards, M. Peck, L. Smith, A. Robles, C. Harris, P1250 190.15 Lipid talk: endocannabinoids regulate mucosal fi S. Di lippantonio and G. Trinchieri. NCI, NIH and Leidos inflammation following helminth infection. M.B. Wiley, Biomed. Res., Inc. H. Batugedara, S. Bobardt, D. Argueta, A. Dillman, P1227 190.2 Type I interferon confers susceptibility to N.V. DiPatrizio and M.G. Nair. Univ. of California, Riverside. Mycobacterium tuberculosis infection within granulomas of P1251 190.16 Candida albicans secrete a small cysteine-rich SIV co-infected non-human primates. J.Y. Phuah. Univ. of protein Sel1 to trigger TLR2/4-dependent inflammatory Pittsburgh Grad. Sch. of Publ. Hlth. response during invasive infection. H. Xiao, W. Wang, P1228 190.3 Characterization of a potential host-directed Z. Deng, T. Li, H. Wu and J. Chen. Institut Pasteur of therapy against TB in non-human primates. C.G. Winchell, Shanghai, China and Chinese Acad. of Sci., China. P.A. Maiello and J.L. Flynn. Univ. of Pittsburgh Sch. of Med. P1252 190.17 CBLB constrains inactivated vaccine-induced P1233 190.4 b-glucan priming enhances neutrophil Fcg CD8+ T cell responses and immunity against lethal fungal receptor-mediated antifungal activity during oral mucosal pneumonia. S.G. Nanjappa, S. Mudalagiriyappa, infection. M. Swidergall, N.V. Solis, Z. Wang, Q.T. Phan, J.S. Fites, M. Suresh and B.S. Klein. Univ. of Illinois at M.E. Marshall, M.S. Lionakis, E. Pearlman and S.G. Filler. Urbana-Champaign and Univ. of Wisconsin, Madison. Univ. of California, Los Angeles, Univ. of California, Irvine and P1254 190.18 Neonatal granulocytic myeloid-derived NIAID, NIH. suppressor cells possess phagocytic properties during P1234 190.5 The role of NKT cells in systemic methicillin- bacterial infection. B.G. Seman, J.K. Vance, M.R. Witt and resistant Staphylococcus aureus infection. S. Genardi, L. Cao, C.M. Robinson. West Virginia Univ. L. Visvabharathy, E. Berdyshev and C-R. Wang. Feinberg P1255 190.19 Upregulation of neuronal VEGF in Sch. of Med., Northwestern Univ. and National Jewish Hlth. experimental cerebral malaria coincides with Dis. severity P1236 190.6 Pathogen evasion of intracellular complement biomarkers in humans: a novel mechanism of in macrophages enables systemic colonization and pathophysiology. C.E. Fain, S. Rana, M.A. Huggins, bacteremia. M. Valeri, L.A. Knodler, J. Behnsen, G.C. Sieck and A.J. Johnson. Mayo Clinic Grad. Sch. of P. Sharma, L. Chung, J. Cundiff, E. Sanchez-Lopez, Biomedical Sci. and Univ. of Minnesota. W. Pandori, M. Lodoen, P. Martin, R. Edwards, M. Karin, P1256 190.20 Microbial activation of B-cells by pattern J. Celli, K. Cadwell, S-P. Nuccio and M. Raffatellu. recognition receptors contributes to the proinflammatory and University of California, San Diego, Washington State Univ., profibrotic milieu in patients with idiopathic pulmonary fibrosis. University of California, Irvine, New York Univ. Sch. of Med. M. Ali, H. Dasari, V. Van Keulen, A. Egan, T. Peikert and and Univ. of California, San Diego. E.M. Carmona. Thoracic Dis. Res. Unit, Mayo Clin. P1238 190.7 Characterization of a novel Plasmodium P1257 190.21 Long pentraxin 3 regulates IL-17A mediated virulence factor. M. Akkaya, A. Bansal, P. Sheehan, immunity to primary and secondary Leishmania major L. Miller and S.K. Pierce. NIAID, NIH. infection. G. Gupta, P. Jia, R. Sharma, R. Zayats, L. Shan, fl P1239 190.8 12/15-lipoxygenase supports in ammatory Z. Mou, T. Murooka, A. Soussi-Gounni, C.I. de Oliveira and cytokine production and PMN recruitment during invasive J.E. Uzonna. Univ. of Manitoba, Canada and Oswaldo Cruz aspergillosis. J.J. Mackel, M. Jones and C. Steele. Univ. of Fndn., Brazil. Alabama, Birmingham and Tulane Univ. Sch. of Med. P1258 190.22 TLR4 abrogates Th1 immune response P1240 190.9 Trehalose-6-phosphate synthase-deletion in against L. infantum infection through IRF1 and IFN- Cryptococcus neoformans elicits rapid innate fungal b-dependent mechanism preventing immunopathology. clearance from the lungs with early neutrophil accumulation. L.A. Sacramento, L. Benevides, S. Maruyama, J. Xu, M. Reynolds, X. He, X. Gao, M. Ivey, J. Kolbe, L. Tavares, K. Fukutani, F. Cunha, R. Almeida, J. Silva R. Lopez, C. Mechler, J. Perfect and M.A. Olszewski. and V. Carregaro. Ribeirão Preto Fac. of Med., Univ. of São Univ. of Michigan Med. Sch. and Duke Univ. Sch. of Med. Paulo, Brazil, Federal Univ. of São Carlos, Brazil and Federal P1241 190.10 Mechanistic investigations of granzyme A- Univ. of Sergipe, Brazil. mediated g9d2 T cell TB protective effects. V. Rasi, M. Xia, P1259 190.23 Neutrophils transiently harbor Mycobacterium D.C. Wood, C.S. Eickhoff and D.F. Hoft. Saint Louis Univ. tuberculosis and represent a metabolically permissive niche for + P1242 190.11 Dynamics of antigen re-exposure to CD8 bacterial growth. L. Huang and D. Russell. Cornell Univ. T cells during Toxoplasma gondii infection. L. Shallberg, P1260 190.24 Gamma delta and natural killer cells in A.T. Phan, D.A. Christian and C.A. Hunter. Univ. of splenocytes of young mice protect immunocompromised Pennsylvania. mice from death in Plasmodium chabaudi infection. P1246 190.12 Induction of a long non-coding RNA, lncRNA- L.B. Richard, M.R. Smith, A.E. Murrray and M.M. Opata. Chr1:1226, by Cryptosporidium infection primes intestinal Appalachian State Univ. epithelial cells for IFN-g-mediated host antimicrobial gene transcription. X-M. Chen, S. Deng, A-Y. Gong, Y. Wang, S-T. Zhang, M. Li, J. Li and N.W. Mathy. Creighton Univ.

108 SUNDAY—POSTER SESSIONS

P1261 190.25 Pulmonary inflammation and Tie2/angiopoietin P1273 190.37 Pathogenic mechanisms of endothelial mediated vascular dysregulation during lethal Orientia damage in severe scrub typhus. L. Soong, B. Trent, tsutsugamushi infection. B.J. Trent, Y. Liang, Y. Xing, Y. Liang, D.W. Bouyer and J. Sun. Univ. of Texas Med. Br. M. Esqueda, W. Yang, N-H. Cho, H-I. Kim, Y-S. Kim, P1276 190.38 Interplay of Wnt b-catenin pathway and T.R. Shelite, J. Cai, J. Sung, D. Bouyer, P. Liu and mTORC1 in pathogenesis of Ehrlichia-induced sepsis. L. Soong. Univ. of Texas Med. Branch and Seoul Natl. M.A. Haloul, A. El Andaloussi and N. Ismail. Univ. of Univ. Col. of Med. Illinois at Chicago. P1262 190.26 Agonizing 4-1BB potently promotes humoral P1277 190.39 CD4+ T cell lineage commitment in immune memory response during experimental malaria. Mycobacterium tuberculosis and Schistosoma mansoni co- R. Vijay, A.J. Sturtz and N.S. Butler. Univ. of Iowa. infected individuals from Kisumu, Kenya. T.A. McLaughlin, P1263 190.27 Understanding mechanisms of disease J. Khayumbi, J. Ongalo, B. Muchiri, J. Tonui, F. Hayara tolerance during intestinal helminth infection. M. Gentile, Odhiambo and C.L. Day. Emory Univ. and Kenya Med. Res. Y. Li, A. Robertson, G. Fontes, E. Kaufmann, N. Khan, Inst., Kenya. H.M. Munter, M. Divangahi and I.L. King. McGill Univ., P1278 190.40 Renewal rates of CD4 and CD11b cells in Canada. mycobacterial granulomas. M. Herbath, S. Marcus, P1264 190.28 STAT3 in T cells regulates protective capacity Z. Fabry and M. Sandor. Univ. of Wisconsin, Madison. of hybrid type 1/follicular helper T cells in persistent mouse P1279 190.41 Deciphering multicellular microenvironment of malaria infection. R. Stephens, A.L. Dent and V.H. Carpio. tuberculosis lung granulomas associated with bacterial control Univ. of Texas Med. Branch and Indiana Univ. Sch. of Med. using high-throughput single-cell mRNA sequencing. P1265 190.29 Ephrin B receptor tyrosine kinase ligands H.P. Gideon, T.K. Hughes, M.H. Wadesworth, modulate the germinal center reaction and control humoral S.M. Fortune, A.K. Shalek and J.L. Flynn. Univ. of immune responses to malaria. A.C. Olatunde, P.N. Mimche, Pittsburgh Sch. of Med., Inst. of Med. Engin. and Sci., MIT, S S.O. Seely, T.P. Stewart and T.J. Lamb. Univ. of Utah Sch. of MIT and Harvard and Harvard Sch. of Publ. Hlth. U fl Med. P1300 190.42 Resistance to in ammasome-mediated nitric N P1266 190.30 Enterohepatic Helicobacter species differ in oxide production is involved in diffuse cutaneous their effects on colonic inflammation and colitis-associated Leishmaniasis. G.F.S. Quirino, L.L. Santos, V.M. Borges colon tumorigenesis in mice. R.R. Alkarkoushi, and D.S. Zamboni. Ribeirao Preto Med. Sch., Brazil and I. Chatzistamou, Y. Hui, M. Nagarkatti, P. Nagarkatti and Oswaldo Cruz Fndn., Brazil. T.L. Testerman. Univ. of South Carolina Sch. of Med. P1301 190.43 Alveolar macrophage maturation is required for P1267 190.31 Mechanisms controlling Cryptococcus efficient killing of GBS in the lung. S.J. Lund, K.A. Patras, intracellular parasitism. P. de Figueiredo, A. Pandey, A. Yamamura, G. Hernandez, O. Lakhdari, V. Nizet and S-L. Ding, Q-M. Qin, R. Gupta, G. Gomez, F. Lin, L.S. Prince. Univ. of California, San Diego. X. Feng, L.F. de Costa, S.P. Chaki, M. Katepalli, E. Case, P1302 190.44 Wnt4 controls early cDC1 commitment to E. Van Schaik, T. Sidiq, O. Khalaf, A. Arenas, suppress type 2 immunity. L-Y. Hung, J.L. Johnson, Y. Ji, K.S. Kobayashi, J.E. Samuel, G. Rivera, R.C. Alaniz, D.A. Christian, K.R. Herbine, C.F. Pastore and D.R. Herbert. S-H. Sze, X. Qian, W.J. Brown, A. Rice-Ficht, W. Russell Univ. of Pennsylvania Sch. of Vet. Med. and Perelman Sch. of and T.A. Ficht. Texas A&M Hlth. Sci. Ctr., Jilin Univ., China, Med., Univ. of Pennsylvania. Leidos Biomed. Res., Inc., Texas A&M Univ., Texas A&M Vet. P1303 190.45 Ex vivo analysis of Plasmodium falciparum- Med., Cornell Univ., Texas A&M Univ. Hlth. Sci. Ctr. and Univ. specific B cell responses to natural malaria infection in of Texas Med. Branch. children and adults. C. Hopp, S. Andrews, M. Chambers, P1268 190.32 Protective role of secreted aspartyl proteinase D.J. Leggat, B. Traore, S.K. Pierce, A.B. McDermott and in murine systemic candidiasis caused by non-albicans P.D. Crompton. NIAID, NIH and Univ. of Sci., Technique and Candida species. M. Shukla, S. Alam and S. Rohatgi. Tech. of Bamako, Mali. Indian Inst. of Tech., Roorkee, India. P1304 190.46 Exploiting the molecular mimicry of Non- P1269 190.33 Drug treatment of tuberculosis diminishes but typeable Haemophilus influenzae with ketodeoxynonulosonic does not abolish the protection against secondary M. acid: confusing the bacterium in its own game. S. Saha, tuberculosis challenge. S.K.C. Ganchua, A.M. Cadena, A. Coady, B. Choudhury, X. Chen, S. Ram, V. Nizet and F.F. Hopkins, S. Fortune and J.L. Flynn. Univ. of A. Varki. Sch. of Med., Univ. of California, San Diego, Univ. of Pittsburgh Sch. of Med. and Harvard Sch. of Publ. Hlth. California, San Diego, Univ. of California, Davis and UMASS P1270 190.34 Ruxolitinib, a selective JAK1/2 inhibitor, for the med. treatment of serious diseases caused by Staphylococcus P1305 190.47 Probiotic exopolysaccharide protects mice aureus superantigens. H. Carnes, B. Mehrkens, from acute Staphylococcus aureus bloodstream infection, M. Stegman and G. Rajagopalan. Edward Via Col. of reducing bacterial burden and limiting inflammation. Osteo. Med. and Virginia Polytechnic Inst. and State Univ. W. Paik, F. Alonzo and K.L. Knight. Loyola Univ. Chicago. P1271 190.35 OmpV, an outer membrane protein that helps P1306 190.48 Functional attributes of protective liver CD8 Salmonella typhimurium in cell adhesion. D. kaur and T cells segregate according to specificities induced by A. Mukhopadhaya. Indian Inst. of Sci. Educ. and Res., India. Plasmodium berghei liver stage antigens. U. Krzych, P1272 190.36 Pre-existing SIV infection decreases cytokine N. Althubaiti, A. Pichugin and S.N. Zarling. WRAIR and responses by T cells in lung during the early stages of M. Catholic Univ. of America. tuberculosis co-infection. E.C. Larson, M.A. Rodgers, A.L. Ellis, C.L. Ameel, T.M. Baranowski, A.J. Balgeman, P.A. Maiello, S.L. O’Connor and C.A. Scanga. Univ. of Pittsburgh Sch. of Med. and Univ. of Wisconsin, Madison.

109 SUNDAY—POSTER SESSIONS

P1307 190.49 Adhesion requirements of methicillin-resistant P1328 190.61 Abstract: Demonstration of TLR response in O. Staphylococcus aureus in bacterial pneumonia and influenza mykiss by the bacterial 23S rRNA motif. K. Head, super-infection. J.A. Grousd, A. Richardson, V. Cooper and K.S. Kobayashi, M.F. Criscitiello and S. Vijayan. Texas J.F. Alcorn. Univ. of Pittsburgh and Children’s Hosp. of A&M Univ. and Texas A&M Hlth. Sci. Ctr. Pittsburgh. P1229 190.62 Indoleamine 2,3-dioxygenase during acute P1309 190.50 Transcriptional profile of CD8+Va7.2+CD161+ toxoplasmosis and the hyporesponsiveness of splenocytes. MAITs reveals distinct gene expression compared to CD8 C.M. Ufermann, S. Eller, A. Domrose,¨ K. Spekker-Bosker memory T cells. C.S. Lindestam Arlehamn, M. Pomaznoy, and W. Daubener¨ . Heinrich-Heine Univ., Dusseldorf, J.G. Burel, R. Kuan, G. Seumois, P. Vijayanand, Germany. D.M. Lewinsohn, A. Sette and B. Peters. La Jolla Inst. for P1274 190.63 mTORC1-mediated macrophage polarization Immunology and Oregon Hlth. & Sci. Univ. into M1 contributes to Ehrlichia-induced sepsis. A. El P1310 190.51 IFN-1 regulates inflammasome activation, Andaloussi, M.A. Haloul, M. Kader, T. Tominello, HMGB1 translocation, and autophagy in hepatocytes during J.Z. Wells and N. Ismail. Univ. of Illinois at Chicago and infection-induced acute liver injury. S.S. Hussain, A. El Univ. of Pittsburgh. Andaloussi, M. Kader, T. Tominello, B. Gordon, M. Scott P1230 190.64 Porphyromonas gingivalis promotes colorectal and N. Ismail. Univ. of Illinois-Chicago and Univ. of Pittsburgh. cancer development by regulating NLRP3 inflammasome P1314 190.52 NK cells negatively regulate CD8 T cells to signaling. Z. wang, X. Wang and Y. Jia. Stomatological promote immune exhaustion and chronic Toxoplasma gondii Hosp. of Sun yat-sen Univ., China. infection. J.P. Gigley, D.L. Ivanova and S.L. Denton. Univ. of P1231 190.65 Gene expression profiling of TRIM family in Wyoming. individuals with latent versus active tuberculosis and reveals P1316 190.53 Anti-asialo GM1 treatment during secondary potential biomarkers for diagnosis. C. Li. Beijing Chest Hosp., Toxoplasma gondii infection is lethal and depletes T cells. Capital Med. Univ., China. S.L. Denton, D.L. Ivanova and J.P. Gigley. Univ. of Wyoming. P1232 190.66 Mycobacterium tuberculosis enhances P1275 190.54 Production of IL-17A by different subsets of gd macrophage P-glycoprotein (MDR-1) expression and activity T cells in response to the commensal Corynebacterium to promote intracellular survival. M. Rajaram, Q. Wu, mastitidis has distinct requirements for IL-1R and TCR A. Hossfeld, A. Gerberick, N. Saljoughian, C. Tiwari, recognition. X. xu, A. St. Leger, W. Zhu, S.J. Bing, C. Tiwari and C. Tiwari. Ohio State Univ. R. Horai, M. Mattapallil and R.R. Caspi. NEI, NIH and P1308 190.67 The increased permeability and inflammatory Univ. of Pittsburgh. response of porcine intestinal epithelial cells caused by P1322 190.55 CCR5-mediated recruitment of NK cells to the Escherichia coli and Salmonella enterica Typhimurium kidney is a critical step for host defense to systemic Candida infections are mitigated by bovine colostrum. M. Blais, albicans infection. S.W. Kang, V.G. Tran, N.Z.N. Nguyen, M. Bouchard, V. Touchette, C. Asselin and M. Lessard. S. Lee, J. Kim, H.J. Kim, J.S. Lee, H.R. Cho and B. Kwon. Agr. and Agri-Food Canada, Canada and Univ. of Sherbrooke. Ulsan Univ. Hosp., Sch. of Med., Republic of Korea and Sch. of P1235 190.68 Adherence of local isolates of Candida species Biological Sci., Univ. of Ulsan, Republic of Korea. to vaginal epithelial cells of apparently healthy and HIV- P1323 190.56 Mycobacterium tuberculosis surface antibody infected women in Nigeria, and pro-inflammatory cytokines breadth responses in high endemic setting: a potential to response in a mouse model. F.E. Emele and E.C. Anieto. confirm disease states using ELISA, Addis Ababa, Ethiopia. Nnamdi Azikiwe Univ., Nigeria. A.G. Yeshanew, T. Wondemagegn, M. Negash, M. Genetu, P1312 190.69 Aging impairs the cellular immune response to M. Zewdie, L. Wassie and W. Admasu. St. Paul Hosp. acute C. difficile infection. L. Abernathy Close, M. Dieterle Millennium Med. Col., Univ. of Gondar, Ethiopia and Armuer and V. Young. Univ. of Michigan. Hansen Res. Inst., Ethiopia. P1311 190.70 Identification and characterization of P1324 190.57 The Mycobacterium tuberculosis PE11 Escherichia coli genes associated with grazing resistance to induces L-arginine-polyamine biosynthesis pathway and the social amoeba Dictyostelium discoideum. M. Snyder, mediate bacillary survival in macrophages. M. Perez-Vazquez, D. Johnson and D.A. Rasko. Towson N.R. Rameshwaram, P. Singh and S. Mukhopadhyay. Univ. and Univ. of Maryland Sch. of Med. Centre for DNA Fingerprinting & Diagnostics, India. P1313 190.71 Mosaic response of T cells to commensal P1325 190.58 Eosinophils in tick transmitted ehrlichial bacteria derived polysaccharide. C.A. Alvarez, M.B. Jones infection. T.B. Saito and D.H. Walker. Univ. of Texas Med. Br. and B.A. Cobb. Case Western Reserve Univ. Sch. of Med. P1326 190.59 Isolation of a 31 kDa protein in Angiostrongylus P1315 190.72 NKp46+ NK cells regulate brain CD4+ T cells cantonensis from Hawaii and its comparative diagnostic to promote chronic Toxoplasma gondii infection. J.P. Gigley, efficacy to the 31 kDa protein from Thailand and crude D.L. Ivanova and S.L. Denton. Univ. of Wyoming. antigen from Hawaii. S.I. Jarvi, K.A. Snook, K. Cannoles, P1317 190.73 The IL-12- and IL-23-dependent NK-cell S. Quarta, P. Eamsobhana, L. Shepherd, Y. Tagami, response is essential for protective immunity against L. Kaluna, K. Howe, S. Jacquier, C. Niebuhr and secondary Toxoplasma gondii infection. S.L. Denton, D. Bicakci. Univ. of Hawaii, Hilo, Mahidol Univ. and USDA, D.L. Ivanova, T. Mundhenke and J.P. Gigley. Univ. of APHIS. Wyoming. P1327 190.60 Polyfunctional CD4+ T cells specific for P1318 190.74 Innate and adaptive immune interactions in Trypanosoma cruzi can be restored after in vitro treatment Coccidioides infection. K.K. Hoyer and A. Diep. Univ. of with IL-7 and IL-27. M.A. Natale, T. Minning, M.G. Alvarez, California, Merced. B. Lococo, M.C. Albareda, G. Bertocchi, R. Tarleton and S. Laucella. Natl. Inst. of Parasitology, Argentina, CTEGD, Univ. of Georgia and Eva Peron Hosp., Argentina.

110 SUNDAY—POSTER SESSIONS

P1319 190.75 ICOS expression is not required for memory P1224 190.84 TcdB-specific plasma cell and memory B cell T cell formation or maintenance, but does promote Tfh cell responses in recurring Clostridiodes difficile infection- differentiation and the humoral response after secondary associated disease. S. Amadou Amani, T. Shadid, Plasmodium chabaudi chabaudi AS infection. L.E. Latham, J.D. Ballard and M. Lang. Univ. of Oklahoma Hlth. Sci. Ctr. D.J. Wikenheiser and J.S. Stumhofer. Univ. of Arkansas for P1253 190.85 Moringa oleifera treatment induces T-cell Med. Sci. and Univ. of Pittsburgh. activation in Plasmodium chabaudi infection. J. Pilotos, P1222 190.76 The role of neutrophils in Pseudomonas N.C. Mowa and M.M. Opata. Appalachian State Univ. aeruginosa chronic suppurative otitis media. P1225 190.86 Mycobacterium tuberculosis extracellular K.M. Khomtchouk, A. Kouhi and P. Santa Maria. Stanford vesicles induce the formation of granuloma-like structures in Univ. Sch. of Med. an in vitro model. I. Wong-Baeza, V.G. Garc´ıa Paredes, P1320 190.77 Incorporation of genetic diversity provides M. Silva-Miranda, B.P. Ruiz-Sanchez,´ J. Castañeda- protection from cerebral malaria in Mus musculus. Casimiro, A. Hernandez-Solis,´ R. Cicero-Sabido, D. Cornwall and B.D. Evavold. Univ. of Utah and Univ. of J. Seraf´ın-Lopez,´ S. Estrada-Parra and I. Estrada-Garc´ıa. Utah, Dept. of Pathology. Instituto Politecnico´ Nacional, Mexico, Universidad Nacional P1321 190.78 Host resistance to pulmonary Mycobacterium Autonoma´ de Mexico,´ Mexico´ and Hospital General de Mexico´ tuberculosis infection requires CD153 expression. “Dr. Eduardo Liceaga”, Mexico. T.W. Foreman, M. Sallin, K.D. Kauffman, C. Riou, E. Du P1226 190.87 Lymphotoxin b receptor: a crucial role in Bruyn, S. Sakai, S. Hoft, C. Nelson, T. Myers, P. Gardina, Toxoplasma gondii infection. A. Wichert, U. Sorg, A. Sher, R. Moore, T. Wilder-Kofie, I.N. Moore, A. Sette, D. Degrandi and K. Pfeffer. Heinrich-Heine Univ., C.S. Lindestam Arlehamn, R. Wilkinson and D.L. Barber. Duesseldorf, Germany. NIAID, NIH, NEI, NIH, Univ. of Cape Town, South Africa and La Jolla Inst. for Allergy and Immunology. 191. GUT MICROBIOTA AFFECTS ON S P1237 190.79 Tuberculosis boosts HIV-1 production by HOST IMMUNITY U macrophages through IL-10/STAT3 dependent tunneling N nanotube formation. G. Lugo, S. Souriant, L. Balboa, Poster Session M. Dupont, K. Pingris, D. Kviatcovsky, C. Cougoule, SUN. 2:30 PM—EXHIBIT/POSTER HALL C. Lastrucci, A. Bah, R. Gasser, R. Poincloux, B. Raynaud-Messina, T. Al Saati, S. Inwentarz, S. Poggi, P1329 191.1 The gut microbiome can contribute to colon + E.J. Moraña, P. Gonzalez-Montaner,´ M. Corti, B. Lagane, tumor susceptibility via an effect on CD8 T cell responses. A.I- I. Vergne, C. Allers, D. Kaushal, M. Kuroda, M. Sasiain, W. Yu, S. Ho, J. Chen, C. Koumpouras, L. Zhao, O. Neyrolles, I. Maridonneau-Parini and C. Verollet. Inst. de P.D. Schloss, K.A. Eaton and G.Y. Chen. Univ. of Pharmacologie et de Biol. Structurale, France, Inst. of Exptl. Michigan and Univ. of Michigan Med. Sch. Med.-CONICET, Argentina, institut de pharmacologie et de P1330 191.2 The role of oral pathobionts in the fl biologie structurale (IPBS), Ctr. for Genomic Regulation, Ctr. pathogenesis of gastrointestinal in ammation. N. Kamada. de Physiopathologie de Toulouse Purpan, France, INSERM/ Univ. of Michigan. UPS/ENVT, Inst. de Tisioneumonologia uRa} ul´ F. Vaccarezza P1331 191.3 Sensing fungal dysbiosis by gut-resident + Ƈ, Argentina, Division de SIDA, Hospital de Infecciosas Dr. F.J. CX3CR1 mononuclear phagocytes aggravates allergic Muñiz, Argentina, Tulane Natl. Primate Res. Ctr. and Univ. of airway disease. X. Li, I. Leonardi, A. Semon, I. Doron, California, Davis. I.H. Gao, G.G. Putzel, Y. Kim, H. Kabata, D. Artis, P1243 190.80 Infection of the spleen by Chlamydia W.D. Fiers, A.E. Ramer-Tait and I. ILIEV. Weill Cornell muridarum following per-vaginal inoculation causes Med. Col. and Univ. of Nebraska, Lincoln. splenomegaly and is essential for its dissemination into the P1332 191.4 Microbiota-derived butyrate limits the gastrointestinal tract. N. Shillova, S.E. Howe and autoimmune response by promoting follicular regulatory V.H. Konjufca. Southern Illinois Univ. Carbondale. T cells. D. Takahashi, N. Hoshina, J.M. Clarke and P1244 190.81 Role of the protein CagA from Helicobacter K. Hase. Keio Univ. Fac. of Pharmacy, Japan and CSIRO pylori in the modifications of the human B lymphocyte Food and Nutritional Sci., Australia. cytoskeleton. R. Cervantes, Z. Piedra-Quintero, P1333 191.5 Toll-like receptor 2/IL-1b signaling is required C. Sandoval-Montes, M. Amieva, J. Torres-Lopez,´ for sensing and responding to a commensal bacterium at the L. Santos-Argumedo and J.L. Maravillas-Montero. ocular surface. W. Zhu, A. St. Leger, F. Almaghrabi, X. Xu UNAM, Mexico, The Ohio State Univ., ENCB, IPN, Mexico, and R. Caspi. NIH. Stanford Univ., IMSS, Mexico and CINVESTAV-IPN, Mexico. P1334 191.6 Increased duration of antibiotic treatment P1245 190.82 B7x expression on the bronchial epithelium progressively alters gut microbiota and revokes protection delays CD4 T cell priming after Mycobacterium tuberculosis from ocular autoimmunity. R.S. Salvador, R. Horai, ’ infection. S. Sakai, K.D. Kauffman, O. Kamenyeva, X. Zang Y. Jittayasothorn, J. Tang, C. O Huigin, V. Thovarai, and D.L. Barber. NIAID, NIH and Albert Einstein Col. of Med. W. Yuan and R. Caspi. NEI, NIH and NCI, NIH. P1247 190.83 Induction of inflammatory responses in P1335 191.7 Metabolic targeting of microbiota-reactive CD4 fl splenocytes by exosomes released from intestinal epithelial T memory cells as an immunotherapy for in ammatory bowel cells following Cryptosporidium parvum infection. X-M. Chen, disease. Q. Zhao, L.W. Duck and C.O. Elson. Univ. of Y. Wang, Y. Shen, H. Liu, J. Yin, S-T. Zhang, A-Y. Gong, Alabama, Birmingham, Sch. of Med. X. Chen, S. Chen, N.W. Mathy and J. Cao. Creighton Univ. and Chinese Ctr. for Dis. Control and Prevention, China.

111 SUNDAY—POSTER SESSIONS

P1336 191.8 Control of mucosal barrier functions and gut P1348 192.2 Osteopontin promotes survival of intestinal microbiome homeostasis by DUSP6 in colitis. C-Y. Kao, intraepithelial lymphocytes and protects against colitis. C-S. Chang, Y-C. Liao, C-T. Huang, J-W. Ruan, C-M. Lin, A. Nazmi, M.J. Greer, K.L. Hoek, M.B. Piazuelo, T-H. Tan and Y-C. Liao. Natl. Hlth. Res. Inst., Taiwan, Taiwan H-H. Weitkamp and D. Olivares-Villagomez. Vanderbilt and Natl. Cheng Kung Univ., Taiwan. Univ. Med. Ctr. P1337 191.9 Functional characterization of the enteric P1349 192.3 Ulcerative colitis-associated E. coli animal virome. S. Dallari, T. Heaney, A. Rosas and pathobionts potentiate colitis in susceptible hosts. H. Yang, K. Cadwell. New York Univ. Sch. of Med. H.C. Mirsepasi-Lauridsen, C. Struve, J.M. Allaire, P1338 191.10 Effect of sodium butyrate supplementation on E. Bosman, A. Sivignon, W. Vogl, C. Ma, G. Reid, X. Li, the gut microbiome during colorectal cancer. H.R.D. Alrafas, A.M. Petersen, K. Jacobson, S. Gouin, N. Barnich, H. Yu, B.P. Busbee, P. Nagarkatti and M. Nagarkatti. Univ. of South K.A. Krogfelt and B.A. Vallance. Univ. of British Columbia, Carolina Sch. of Med. Canada, Statens Serum Inst., Denmark, Clermont Univ., P1339 191.11 CD160-HVEM signaling in intestinal epithelial France., Lerner Res. Inst., Hvidovre Univ. Hosp., Denmark cells modulates gut microbial homeostasis. G-Y. Seo, and LUNAM Univ., France. J-W. Shui, Z. Mikulski, Q. Wang, D. Takahashi, P1350 192.4 Enhancement of gut barrier function by D.A. Giles, H. Iwaya, A. Sethi, P-H. Kim, H. Cheroutre microbial metabolite, urolithin A via AhR-Nrf2 dependent and M. Kronenberg. La Jolla Inst. for Immunology and pathways in IBD. V.R. Jala, R. Singh, Kangwon Natl. Univ.m, South Korea. S. Chandrashekarappa, S.R. Bodduluri, B.V. Becca, P1341 191.12 Cytokine mediated control of microbiota and B. Hegde, N. Kotla, A.A. Hiwale, T. Saiyed, P. Patel, inflammation in atherosclerosis. E. Koltsova, I. Peshkova, M. Vijay-Kumar, M. Langille, G.M. Douglas, G. Dryden, A. Dzutsev, T. Aghayaev, S. Hazen, G. Trinchieri and X. Cheng, E. Rouchka, S.J. Waigel, H. Alatassi, A. Fatkhullina. Fox Chase Cancer Ctr., NCI, NIH and H-G. Zhang, B. Haribabu and P.K. Vemula. Univ. of Cleveland Clin. Louisville, Univ. of Louisville., Inst. for Stem Cell Biol. and P1342 191.13 Zinc supplementation modulates T helper 17 Regenerative Med., India, Centre for Cellular and Molec. cells via the gut microbiome. S.R. Gordon and S. Vaishnava. Platforms, India, The Univ. of Toledo Col. of Med. and Life Brown Univ. Sci. and Dalhousie Univ., Canada. P1343 191.14 Oral administration of Lactococcus lactis P1352 192.5 Identification of novel loci controlling IBD displayed influenza neuraminidase and ectodomain of matrix susceptibility utilizing the genetic diversity of wild-derived protein 2 induce strong mucosal and systemic immune mice. K.G. Lahue, J. Crothers, B. Lavoie, Q. Fang, responses in chickens. A. Lahiri and A.I. Mallick. Indian G. Mawe and D. Krementsov. Univ. of Vermont. Inst. of Sci. Educ. and Res. Kolkata, India. P1353 192.6 Gut IgA abundance in adult life can protect P1344 191.15 Microbiota metabolites SCFA stimulate from DSS colitis even if maternal IgA received in early life is epithelial migration to promote wound healing through inadequate. S. Gupta, S. Basu, V. Bal, S. Rath and MFGE8 and PAK1. A.J. Bilotta, C. Ma, X. Huang, A. George. Natl. Inst. of Immunology, India and Weill W. Yang, S. Yao and Y. Cong. Univ. of Texas Med. Br. Cornell Med. P1340 191.16 Intestinal IL-17R signaling controls liver P1355 192.7 Targeting gut inflammation inhibits alcohol- inflammation by constraining microbiome-induced TLR9 induced liver disease. Z. Deng, S. Chu, X. Gu and M. Liu. signaling and IL-18 production. P. Castillo, P. Kumar, Univ. of Louisville. T.W. Hand and J.K. Kolls. Univ. of Pittsburgh Sch. of Med. P1356 192.8 Lingo3 interacts with TFF2 to control mucosal and Stony Brook Univ. integrity, type 1 inflammation, and colitic tissue repair. K. Zullo, P1345 191.17 Bacteria in human intestine contribute to Y. Ji, Y. Wei, K. Herbine, N. Maloney, R. Cohen, C. Pastore, mucosal immune function in utero. E. Rackaityte, M. Somsouk, S. Srivatsa, L-Y. Hung, M. Kohanski, J. Halkias, E.M. Fukui, V. Mendoza, E.D. Crawford, N. Cohen and D. Herbert. Univ. of Pennsylvania Sch. of K. Fujimura, T. Burt and SusanV. Lynch. Univ. of Vet. Med., Univ. of California, San Francisco and Perelman California, San Francisco and Chan Zuckerberg Biohub. Sch. of Med., Univ. of Pennsylvania. P1346 191.18 Short- and long-term impact of prebiotic P1357 192.9 Persistent IL-1b signaling aggravates murine supplementation during infancy on immune activity in Wistar enteropathogen, Citrobacter rodentium infection in mice. rats. M.P. Jeffrey, S.T. Clarke, N. Krysa, S.P.J. Brooks, B. Yeoh, P. Saha, R.M. Golonka and M. Vijay-Kumar. M.L. Kalmokoff, J. Green, F. Matias and J.M. Green- Univ. of Toledo Col. of Med. and Life Sci. Johnson. Univ. of Ontario Inst. of Technol., Canada, Univ. P1358 192.10 Maternal immunoglobulin A protects against of Alberta, Canada, Hlth. Canada, Canada and Agr. and Agri- the development of necrotizing enterocolitis in preterm Food Canada, Canada. infants. T.W. Hand, K. Gopalakrishna, B.R. Macadangdang, M. Rogers, J.T. Tometich, J. Ji, 192. IMMUNITY DURING INTESTINAL DISEASE B.A. Firek, R. Baker, A.H.P. Burr, C. Ma, M. Good and M. Morowitz. Univ. of Pittsburgh, David Geffen Sch. of Poster Session Med., UCLA, Univ. of Pittsburgh Sch. of Med., Sch. of Med., SUN. 2:30 PM—EXHIBIT/POSTER HALL Tsinghua Univ., China and Washington Univ., St. Louis. P1359 192.11 Gut antibody deficiency in CD19-/- mice results P1347 192.1 IL-17 receptor and IL-22 receptor signaling in in a spontaneous Celiac-like sprue. A.D. Mohammed and Citrrobacter rodentium infection. Y. Matsunaga, A. Wanek, J.L. Kubinak. Univ. of South Carolina Sch. of Med. K. Song, C. Flemington, T. Clark, J. Bitoun and J. Kolls. Tulane Univ. Sch. of Med.

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P1360 192.12 Indole-3-carbinol prevents murine colitis P1377 193.2 Lactobacillus reuteri reduces the severity of development via an IL-22-dependent mechanism that experimental autoimmune encephalomyelitis in mice by regulates anti-microbial peptides and mucus production. modulating gut microbiota. Y. Liu, B. He, T.K. Hoang, P.B. Busbee, H. Alrafas, N. Dopkins, M. Nagarkatti and X. Tian, C.M. Taylor, E.E. Blanchard, M. Luo, P.S. Nagarkatti. Univ. of South Carolina Sch. of Med. M.B. Bhattacharjee, J. Freeborn, S. Park, J. Couturier, P1363 192.13 Mast cells in patients with hereditary J.W. Lindsey, D.Q. Tran and J.M. Rhoads. Univ. of Texas a-tryptasemia promote HLA-DR expression and a Th2- Hlth. Sci. Ctr., Houston McGovern Med. Sch., Univ. of Texas polarizing microenvironment in the gastrointestinal tract. MD Anderson Cancer Ctr. and Louisiana State Univ. Sch. of J.F. Shirley, J. Drourr, W.T. Edwards, K. Tuna, Med. L.K. Ryan, A. Alli, Y. Tang and S.C. Glover. Univ. of Florida. P1379 193.3 GMCSF-neuroantigen vaccines engender P1361 192.14 Depletion of embryonic macrophages impairs FOXP3+ regulatory T cell responses through low-efficiency vascular development in the murine neonatal small intestine self-antigen recognition events integrated through and increases mortality in an experimental model of necrotizing diminished CD40L-CD40 signaling. C.D. Moorman and enterocolitis. E. Managlia, X. Yan and I.G. De Plaen. Ann and M.D. Mannie. East Carolina Univ. Robert H. Lurie Childrens Hosp. of Chicago. P1503 193.4 The cytoplasmic domain of CTLA-4 control P1362 192.15 Intestinal epithelial cells differentiated from iPS autoimmunity via inducing regulatory T cells. G-R. Kim, cells suppressed bacterial translocation in an organ model of S. Lim, J-U. Lee and J-M. Choi. Hanyang Univ. alcohol-induced intestinal epithelial dysfunction. I. Ito, P1502 193.5 Alcohol consumption leads to sex-specific S. Jacob, S. Suzuki, M. Kobayashi and F. Suzuki. Univ. amelioration of disability in a mouse model of multiple of Texas Med. Br. and Univ. of North Texas Hlth. Sci. Ctr. sclerosis. B. Caslin, A. Karmakar, C. Maguire, P1351 192.16 Chronic immune barrier dysregulation among K. Helmsdoerfer, K. Mohler, S. Kirwin, D. Wylie and women with a history of violence victimization. A. Kohlmeier, E. Melamed. Univ. of Texas, Austin. S L.B. Haddad, T.Z-R. Li, K.A. Brookmeyer, J.M. Baker, P1371 193.6 The effect of Chinese herbal medicine U C.Y. Chen, E.N. Kersh, M.M. Herbst-Kralovetz, compound, CS029, in suppression of dendritic cells and its N M. Hogben, I. Ofotokun and J.E. Kohlmeier. CDC, Emory therapeutic application in experimental autoimmune Univ. Sch. of Med. and Univ. of Arizona. encephalomyelitis. Y-C. Song and H-R. Yen. China Med. P1354 192.17 Mapping the generation and fate of Tregs Univ., Taiwan. associated with recovery of autoimmune disease. D.J. Lee P1374 193.7 Non-redundant requirement for CXCR3 and F. Muhammad. Univ. of Oklahoma Hlth. Sci. Ct. signaling for effective treatment of CNS autoimmunity with P1364 192.18 IFNgand poly(I:C) primed MSCs enhances the type I interferon. J. Chen, W.P. Chong, W. Wang, C. Li, therapeutic effects on DSS induced colitis via enhancing I. Gery and R.R. Caspi. Sun Yat-sen Univ., China and NEI, indoleamine 2, 3-dioxygenase and inducing regulatory T cell NIH. phenotype. J-Y. Lim, D-B. Ryu, S-E. Lee, G. Park and P1370 193.8 Identification of markers of relapse in a C-K. Min. Col. of Med., The Catholic Univ. of Korea, South relapsing-remitting mouse model of multiple sclerosis. Korea. C.A. Chase and T. Forsthuber. Univ. of Texas, San A. P1365 192.19 Optimizing steroid administration in murine P1368 193.9 Efficacies of anti-CD20 antibody and atacicept models of Citrobacter rodentium-induced acute phase colitis. are differentially impacted by B cell maturation antigen in S.T. Clarke, T. Shelton, V. Boras, H. Brumer, C.Q. Wang, neuro-autoimmunity. G. Kumar, R.M. Ko and R.C. Axtell. D.W. Abbott, X. Xing, R.R.E. Uwiera and G.D. Inglis. Oklahoma Med. Res. Fndn. Lethbridge Res. and Develop. Ctr., Canada, Univ. of British P1501 193.10 Human neural stem cells induce central Columbia, Canada and Univ. of Alberta, Canada. nervous system specific regulatory T cells from the ex Treg P1366 192.20 Synergy between T-dependent antibodies and pool and promote repair in models of multiple sclerosis. IL-10 limits susceptibility to inflammatory bowel disease. S.A. Greilach, L.L. McIntyre, J. Hasselmann, S. Othy, A.E. Landuyt, B.J. Klocke, T.R. Schoeb and Q. Nguyen, K. Kessenbrock, M.D. Cahalan, M. Blurton- C.L. Maynard. Univ. of Alabama at Birmingham. Jones, T. Lane and C.M. Walsh. Univ. of California, Irvine P1367 192.21 Short-term antibiotic treatment immediately and Univ. of Utah, Sch. of Med. after weaning prevents spontaneous ileocolitis. C.L. De P1373 193.11 Neuroantigen-specific regulatory CD8+ T cell Ciantis, J.C. Jeschke, M.A. Hadiono, J. Ziegelbauer, responses as a therapy for relapsing autoimmune S. Singh, M. Suchi, N.H. Salzman and C.B. Williams. demyelinating disease. A.A. Brate, F.R. Itani, L.L. Pewe, Med. Col. of Wisconsin. J.T. Harty and N.J. Karandikar. Carver Col. of Med. Univ. of Iowa. 193. ADVANCES IN THERAPEUTIC APPROACHES P1378 193.12 IL-22 and Reg3g overexpression affects FOR NEUROIMMUNOLOGIC DISEASES experimental autoimmune encephalomyelitis severity. A. Eken, M.F. Yetkin, F.Z. Okus, M. Cakir, M.O. Karayigit, Poster Session S. Erdem, Y. Haliloglu, M. Oukka, H. Donmez Altuntas, SUN. 2:30 PM—EXHIBIT/POSTER HALL M. Mirza and H. Canatan. Erciyes Univ., Cumhuriyet Univ. and Univ. of Washington Sch. of Med. P1369 193.1 AS101 ameliorates experimental autoimmune P1500 193.13 The aryl hydrocarbon receptor as a regulator of uveitis by regulating Th1 and Th17 responses and inducing CNS autoimmunity. J. Kenison-White, A. Jhaveri, S. Tezza, Treg cells. S.J. Bing, I. Shemesh, W.P. Chong, D. Nowakowska, D. Sherr and F.J. Quintana. Boston Univ. Y. Jittayasothorn, P.B. Silver, B. Sredni and R.R. Caspi. Sch. of Med., AnTolRx, Inc. and Brigham and Women’s Hosp., NEI, NIH, Bar-Ilan Univ., Israel and Sun Yat-sen Univ., China. Harvard Med. Sch.

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P1372 193.14 Myelin basic protein specific TCR-engineered P1505 194.10 Increased activated platelet binding to T cells in regulatory T cells from multiple sclerosis patients are lung cancer patients is correlated with history of thrombosis. suppressive to MBP-specific T effector cells. A. de Paula C.K. Meikle, A. Meisler, P. Garg, C.A. Kelly, J.A. Jeffries, Alves Sousa, Y.C. Kim, S. Jacobson and D.W. Scott. T. Gao, C.M. Bird, J.C. Willey and R.G. Worth. Univ. of Uniformed Serv. Univ. of the Hlth. Sci. and NINDS, NIH. Toledo. P1375 193.15 Deficiency in B cell maturation antigen reveals P1506 194.11 Preclinical development of natural compound gender differences in experimental autoimmune emodin as an agent to halt breast cancer metastasis. D. Fan, encephalomyelitis. G. Kumar, R.M. Ko and R.C. Axtell. Q. Liu and J. Hodge. Univ. of South Carolina. Oklahoma Med. Res. Fndn. P1507 194.12 RELT stains prominently in B cell lymphomas P1376 193.16 Photobiomodulation therapy regulates the and binds proteins associated with leukemia. J.K. Cusick, production of IL-10 and IFN-g by peripheral blood Y. Alhomsy, G. Talbott, C. Sumida, D. Aghaians, N. Hejazi mononuclear cells and CD4+ T cells isolated from subjects and A. Jacobs. California Univ. of Sci. and Med., California with multiple sclerosis. M. Tolentino, C.C. Cho and Northstate Univ. and Univ. of Hawaii, Hilo. J-A. Lyons. Univ. of Wisconsin, Milwaukee. P1508 194.13 The significance of spontaneously immortalized B lymphocytes from patients with AIDS-related 194. NOVEL TUMOR TARGETS AND THERAPIES non-Hodgkin’s lymphoma and HIV-infected individuals. K. Zhuang, Y. Zhang, L. Zhou, X. Qi, X. Xu, F. Meng, Poster Session Z. Xu, J. Liu, L. Shao, Y. Xiong, H. Ke and X. Gui. Wuhan SUN. 2:30 PM—EXHIBIT/POSTER HALL Univ., China. P1509 194.14 Gemcitabine promotes tumor cell-derived — P1514 194.1 JAML-CAR a mechanism of T cell antitumor inflammatory responses leading to immunosuppression. immunity. J.M. McGraw, D. Witherden and W.L. Havran. C. Ding and J. Yan. Univ. of L.ville. Scripps Res. Inst. P1510 194.15 Tumor exosome mediated immune regulation P1516 194.2 Butyrophilin 3A1 is a dynamic T cell regulator in in colorectal cancer. S. Subramanian, X. Zhao and C. Yaun. ovarian cancer. K.K. Payne, R. Chaurio Gonzalez, J. Perez Univ. of Minnesota. Sanz, C.M. Anadon Galindo, S. Biswas, J.A. Mine, P1511 194.16 Immune characteristics in PBMC of patients A. Perales-Puchalt, E. Tsiganov, T.L. Costich, with hepatitis B virus-associated early-stage hepatocellular C.M. Harro, A.K. Marrs, J. Lajoie, K-P. Li, M. Ophir, carcinoma revealed by mass cytometry. W. Wang, B. Xu, U. Eskiocak, M. Schmidt, D.I. Gabrilovich and L. Qiao, J. Yin, A. Dou, D. Lin, Y. Zang and D. Chen. fi J.R. Conejo-Garcia. Mof tt Cancer Ctr. and Res. Inst., Beijing Youan Hosp., China. Wistar Inst. and Compass Therapeutics. P1512 194.17 Epigenetic mediated immune exhaustion P1524 194.3 Combination of anti-CD40 and anti-PD1 revert persists after successful tuberculosis therapy. A.R. DiNardo, M2 polarization to limit tumor growth in a genetically K. Rajapakshe, T. Nishiguchi, G. Mtetwa, G. Maphalala, engineered bladder cancer mouse model. G. Verdeil, G. Makedonas, C. Coarfa and A.M. Mandalakas. Baylor Col. M. Leblond, C. Imbratta and D.E. Speiser. Univ. of of Med., Baylor-Swaziland Children’s Fndn., Swaziland and Lausanne, Switzerland. Swaziland Ministry of Hlth., Swaziland. P1526 194.4 Inhibition of NK cell-MHCI interactions disrupts P1513 194.18 Antitumor effect of metformin: what about immune homeostasis by activation of the IFNg/IL15 axis Burkett’s lymphoma? X. Wan, G. Zhang, S. Huang, Z. Liu, resulting in augmentation of anti-tumor immunity. L. Liu, Z. Lu and C. Tang. Chinese Acad. of Sci., China. A.K. Panda and E.M. Shevach. NIAID, NIH. P1515 194.19 miRNA signature derived from GBM plasma P1528 194.5 T cell intrinsic mechanisms of resistance to PD- exosomes as a diagnostic biomarker. L.M. Cumba Garcia, 1 checkpoint blockade. M. Krogsgaard, D. Moogk, L. Wang, P. Chanana, A.J. Johnson and I.F. Parney. Mayo Clin. Grad. K. Li, Z. Yuan, J. Weber, I. Osman and C. Zhu. New York Sch. of Biomed. Sci. and Mayo Clin., Rochester, Minnesota. Univ. Sch. of Med., Georgia Inst. of Tech., NYU Med. Ctr. and P1517 194.20 Human intrinsic immunity factor SLFN11 New York Univ. Med. Ctr. promotes cell death upon DNA damages through cleavage fi P1530 194.6 Virus-speci c memory T cells populate tumors of distinct type II tRNAs and inhibition of proteins syntheses and can be repurposed as a tumor immunotherapy. P. Rosato, related to DNA damage responses and repairs. M. Li, E. Kao, S. Wijeyesinghe, M. Stolley, C. Nelson, R.L. Davis, D. Malone, X. Gao, J.Y.J. Wang and M. David. Univ. of L.S. Manlove, C.A. Pennell, B.R. Blazar, C.C. Chen, California, San Diego. M.A. Geller, V. Vezys and D. Masopust. Univ. of Minnesota. P1518 194.21 High-dimension flow cytometry reveals P1531 194.7 Low-dose neoadjuvant chemotherapy comprehensive deviations in immunophenotypes associated - dominates Ki67 quiescent tumor dormancy for an effective with non-response to melanoma immunotherapies. immunotherapy of breast cancer. H. Aqbi, C. Coleman, D.M. Woods, A. Laino, A. Winters, J. Alexandre, M. Idowu and M. Manjili. Virginia Commonwealth Univ. J. Weber and P. Chattopadhyay. New York Univ. Med. Ctr. P1533 194.8 Type I interferon suppresses tumor growth P1519 194.22 The natural human IgG1 mAb Pritumumab through activating the STAT3-granzyme B pathway in tumor- targets cell surface expressed vimentin and inhibits tumor fi in ltrating cytotoxic T lymphocytes. C. Lu, J.D. Klement, growth. M.C. Glassy, I. Babic, R. Mukthavaram, P. Jiang, M.L. Ibrahim, P.S. Redd, G. Zhou and K. Liu. Augusta Univ. N. Nomura, E. Glassy and S. Kesari. Univ. of Calif., San P1504 194.9 The dark side of IL-1: role in prostate cancer Diego, Moores Cancer Ctr., John Wayne Cancer Inst. and progression. O.O. Udartseva and S.O. Gollnick. Roswell Pathology, Inc. Park Cancer Inst. P1520 194.23 The role of nano-particulate carbon black in lung cancer development. C-Y. Chang, R. You and F. Kheradmand. Baylor Col. of Med.

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P1521 194.24 CD146 contributes the metastatic properties P1540 194.37 Hypoxia-inducible factor-1a is upregulated in and antitumor immunity of human colon adenocarcinoma natural killer cells by interleukin-2 and hypoxia via PI3K/mTOR cells. K. Kato, Y. Shimizu and T. Yamazaki. Toyo Univ., signaling pathway. E.R. Cluff, J. Nolan, C. Collins, Japan. A. Varadaraj and N. Rajasekaran. Northern Arizona Univ. P1522 194.25 IFN-g inhibit ALDHbr breast cancer cells in P1541 194.38 Immune cell phenotype and cytokine secretion murine 4T1 tumor model. G. Shi, X. Zhuang, Y. Wu and in mouse breast cancer responding to anti-CD47 antibody R. Heller. Old Dominion Univ. Res. Fndn., Affiliated Hosp. treatment. C.K. wen, J. Elia, L. Loter, T. Rafizadeh, of Jiangsu Univ., China and Sch. of Preclinical Med., Wannan W. Jiang, H. Zhang and X. Yang. BioLegend, Inc. Med. Col., China. P1542 194.39 Enhancing the immune microenvironment by P1523 194.26 Complete workflows allow comprehensive targeting a vascular three prime exonuclease. S. Anand and tumor microenvironment analysis and culture of cell subsets C. Espinosa-Diez. Oregon Hlth. & Sci. Univ. of limited tumor patient samples. C. Evaristo, R. Siemer, P1543 194.40 Quantification of a spectrum of adhesion E. Criado-Moronati, A. Baranska, P. Gert, D. Agorku, molecules in metastatic cancer patient samples using a O. Hardt, D. Vorholt, A. Singh, C. Dose, B. Heemskerk multiplex bead-based immunoassay panel. A. Zhao, and A. Richter. Miltenyi Biotec, Germany. J. Lehmann, B. Sun, W. Jiang and S. Ji. BioLegend, Inc. P1525 194.27 Therapeutic induction of tertiary lymphoid P1544 194.41 TNF superfamily cytokines overcome immune structures in melanoma using STING agonists. evasion in medulloblastoma. R. Wechsler-Reya, M. Chelvanambi, J.L. Taylor, R.J. Fecek and A. Garancher, H. Suzuki, S. Haricharan, M. Beigi Masihi, W.J. Storkus. Univ. of Pittsburgh and Univ. of Pittsburgh J.M. Rusert, P.S. Norris, F. Carrette, M.M. Romero, Sch. of Med. S.A. Morrissy, P. Skowron, F.M.G. Cavalli, H. Farooq, P1527 194.28 Intratumoral delivery of RIG-I agonist induces V. Ramaswamy, S.J.M. Jones, R.A. Moore, A.J. Mungall, robust anti-tumor immune responses. X. Jiang, O. Fedorova, Y. Ma, N. Thiessen, Y. Li, A. Morcavallo, L. Qi, S M. Linehan, H. Dong, A.M. Pyle and A. Iwasaki. Yale Univ. J.J. Henderson, J.R. Crawford, M.L. Levy, J.M. Olson, U Sch. of Med. Y-J. Cho, A. Deshpande, X-N. Li, L. Chesler, M.A. Marra, N P1529 194.29 Deep characterization of tumor O.J. Becher, L.M. Bradley, C.F. Ware and M.D. Taylor. NCI- microenvironments using single cell multi-omics analysis. Designated Cancer Ctr., Sanford Burnham Prebys Med. L. Montesclaros, S.C. Boutet, S.E.B. Taylor, Discovery Inst., Hosp. For Sick Children, Canada, Lester & M.J.T. Stubbington, V. Giangarra, J.K. Lau, J. Sapida, Sue Smith Breast Ctr., Baylor Col. of Med., Infectious and S. Ziraldo, K.A. Pfeiffer, G. Zheng, A.M. Barrio, J.Y. Lee, Inflammatory Dis. Ctr., Sanford Burnham Prebys Med. S. Marrs, K. Wu and T.S. Mikkelsen. 10x Genomics. Discovery Inst., Northwestern Univ., Canada’s Michael P1532 194.30 Histotripsy initiates local and systemic Smith Genome Sci. Centre, Canada, Inst. of Cancer Res., immunological response and reduces tumor burden in United Kingdom, Texas Children’s Hosp., Baylor Col. of Med., breast cancer. A.D. Hendricks, J. Howell, R. Schmieley, Oregon Hlth. & Sci. Univ., Rady Children’s Hosp. and Fred S. Kozlov, A. Simon, S.L. Coutermarsh-Ott, Hutchinson Cancer Res. Ctr. E. Vlaisavljevich and I.C. Allen. Virginia Tech and Virginia- P1545 194.42 Identification and characterization of a unique Maryland Col. of Vet. Med. KLRG1-expressing subset of CD4+FOXP3+ Tregs in non- P1534 194.31 Irreversible electroporation stimulates a pro- small cell lung cancer. D.O. Adeegbe, D. Noyes, inflammatory tumor microenvironment in pancreatic cancer. J. Semidey-Hurtado and W. Gamal. Moffitt Cancer Ctr. R.M. Brock, N.B. White, V.M. Ringel-Scaia, and Res. Inst. S.L. Coutermarsh-Ott, K. Eden, J. Coutri, P1546 194.43 Therapeutic targeting of the N. Manuchehrabadi, R.V.C. Davalos and I.C. Allen. immunosuppressive axis in ovarian cancer using dietary Virginia Polytechnic Inst. and State Univ., Virginia-Maryland supplements. D. Bollino and T.J. Webb. Univ. of Maryland. Col. of Vet. Med. and Res. and Develop., Angiodynamics. P1547 194.44 The NOD-like receptor NLRP12 plays a critical P1535 194.32 Connecting blood and intratumoral Treg role in hepatic inflammation and cancer. H. Zaki and activity in predicting future relapse in breast cancer. S.M.N. Udden. Univ. of Texas Southwestern Med. Ctr. L. Wang. Beckman Res. Inst., City of Hope. P1548 194.45 Inhibition of PI3K promotes anti-tumor immune P1536 194.33 Detection and quantification of circulating responses to mantle cell lymphoma. S.C. Shissler and tumor cells in PBMCs or blood using flow cytometry. M. Lei, T.J. Webb. Univ. of Maryland, Sch. of Med. P. Ye, A. Wang, N. Li and X. Wang. ACEA Biosciences. P1537 194.34 SUMOylation of ROR-gt inhibits IL-17 195. CO-INHIBITORY AND CO-STIMULATORY expression and colon cancer via HDAC2. V.K. Poojary. SIGNALS IN TUMOR THERAPY Baylor Inst. for Immunology Res. P1538 194.35 Targeting the tumor microenvironment with the Poster Session monoclonal antibody Tocilizumab, reduces IgM secretion in SUN. 2:30 PM—EXHIBIT/POSTER HALL Waldenstrom¨ macroglobulinemia. W. Han, S.J. Matissek, D. Jackson, B. Sklavanitis and S.F. Elsawa. Univ. of New P1552 195.1 Humanized PD-1/PD-L1 mice facilitate the Hampshire and Northern Illinois Univ. direct functional comparison of immune checkpoint inhibitors P1539 194.36 Weighted gene co-expression network in vivo. W.J. Barham, S.M. Harrington, X. Liu and H. Dong. analysis of CXCL13, CXCR5, and associated genes in Mayo Clin. + + multiple myeloma. O.O. Adebayo, C.D. Young, K. Carey, P1554 195.2 CD39 CD8 T cells exhibit a distinct phenotype fi fi + C.D. Dill, S.K.K. Nunez, T.L. Griffen, S. Jain and among tumor-in ltrating tumor-antigen-speci c CD8 T cells. J.W. Lillard. Morehouse Sch. of Med. Y. Lee, J. Park, S-H. Park and E-C. Shin. Korea Advanced Inst. of Sci. and Technol., South Korea.

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P1560 195.3 Multidimensional single T cell analysis reveals P1558 195.14 PD-1 expressions on monocytes from patients altered T cell biology upon treatment of murine tumor with with hepatocellular carcinoma differs depending on the checkpoint blockade immunotherapy. S. Rao, A. Kornberg, progression of the cancer. H. Ohama, A. Asai, S. Lin, K. Gharib, L. Koganti, J.A. Garcia-Vilas Garcia, Y. Tsuchimoto, S. Fukunishi and K. Higuchi. Osaka Med. K. Masuda and A. Han. Columbia Univ. Med. Ctr. Col., Japan. P1550 195.4 Human CD96 correlates to NK cell exhaustion P1559 195.15 GITR agonism triggers antitumor immune and predicts the prognosis of human hepatocellular carcinoma. responses through IL-21–expressing follicular helper T cells. C. Sun, H. Sun, H. Wei, R. Sun and Z. Tian. Univ. of Science C-H. Koh, I-K. Kim, T-S. Kang, K-S. Shin, I. Jeon, B. Song, and Technology of China, China. J-M. Lee, J. Im, Y. Kang and C-Y. Kang. Col. of Pharmacy, P1565 195.5 Surface and cytoplasmic tumor cell PD-L1 Seoul Natl. Univ., South Korea and Grad. Sch. of Convergence differentially mediate virulence in ovarian cancer and Sci. and Technol., Seoul Natl. Univ., South Korea. melanoma through mTOR activation. H.G. Hambright, P1562 195.16 Adipocyte PD-L1 modulates PD-1/PD-L1 H.B. Gupta, A.S. Padron, R. Vadlamudi, Y. Chen, checkpoint blockade cancer immunotherapy efficacy. B. Wu, P.A. Osmulski and T.J. Curiel. Univ. of Texas Hlth. Sci. X. Sun, H.B. Gupta, T.J. Curiel and R. Li. George Washington Ctr., San Antonio. Univ. and Univ. of Texas Hlth. Sci. Ctr., San Antonio. P1561 195.6 B cells produce IL-27 to upregulate PD-L1 P1563 195.17 Cell-intrinsic programmed death ligand-1 expression and promote breast cancer development. inhibits cytotoxic chemo, promotes DNA damage repair, and H. Yan, S. Viswanadhapalli, D. Chupp, M. Fernandez, enhances ATM/ATR signaling following exposure to DNA S. Wu, J. Wang, J. Moroney, J. Taylor, J. Im, C. Rivera, damaging agents in bladder, melanoma, and ovarian cancer Y. Luo, J. Liu, G. Sareddy, P. Casali, R. Vadlamudi and cells. A.V. Kornepati, D. Zhang, H.G. Hambright, S.C. Kari, Z. Xu. Univ. of Texas Hlth. Sci. Ctr. San Antonio. Y. Deng, C.A. Clark, H.B. Gupta, R. Chakravarty, Y. Hu, R. Li P1602 195.7 Precisely timed histone deacetylase inhibition and T.J. Curiel. Univ. of Texas Hlth. Sci. Ctr., San Antonio and creates a highly proliferative intratumoral CD8 T cell population George Washington Univ. and sensitizes tumors to checkpoint blockade. T.R. McCaw, P1564 195.18 PD-1 checkpoint therapy promotes pro- M. Liu, M. Li, D. Starenki, S. Cooper, R. Arend, A. Forero, survival phenotype in regulatory T cells in a model of D. Buchsbaum and T.D. Randall. Univ. of Alabama at claudin-low breast cancer. S.C. Vick, C.M. Perou and Birmingham and HudsonAlpha Inst. for Biotech. J.S. Serody. Univ. of North Carolina, Chapel Hill. P1549 195.8 HHLA2 expression in human clear cell renal P1566 195.19 B7H3 regulates tumor-mediated Th1 type cell carcinoma is significantly associated with patient’s immune responses. J.S. Lee, M.E. Kim and J.H. Cho. prognosis and promotes cancer progression. L. Chen and Chosun Univ., South Korea. J. Jiang. Soochow Univ., Taiwan. P1567 195.20 All-trans retinoic acid downregulates NKp30 P1551 195.9 IL-6, IL-8 drive LAG3/PD1 immune ligand B7-H6 on tumor cells transcriptionally and suppression on effector and na¨ıve, peripheral blood CD8+ posttranscriptionally. G. Cao, R. Sun and Z. Tian. Univ. of T cells in cancer patients. A. Somasundaram, A. Cillo, Sci. and Technol. of China, China. L. Oliveri, J. Herman, J. Kirkwood, R.L. Ferris, P1568 195.21 CD73-dependent tumor resistance to agonistic T.C. Bruno and D. Vignali. Univ. of Pittsburgh Sch. of Med. anti-4-1BB therapy through TGF-b. S. Chen, J. Fan, and Univ. Pittsburgh Med. Ctr. Hillman Cancer Ctr. M. Zhang, L. Qin, D. Dominguez, A. Long and B. Zhang. P1553 195.10 Immune checkpoint inhibitors reverse T-cell Feinberg Sch. of Med., Northwestern Univ. and Zhengzhou functional suppression in the bone marrow of a subset of Univ., China. AML patients. E.F. Lind, A.J. Lamble, Y. Kosaka, P1569 195.22 Viral infection induces the upregulation of T. Laderas, L. Brady, F. Huang, B.J. Druker, J.W. Tyner MHC-1 expression in infected cancer cells. S.H. Kim and and S. McWeeney. Oregon Hlth. & Sci. Univ., Seattle Y.W. Jung. Korea Univ., South Korea. Children’s Hosp., Janssen Res. and Develop. and Howard P1570 195.23 Adrenergic stress impairs CD8+T-cell Hughes Med. Inst. activation and effector function, limiting anti-tumor immune P1555 195.11 A novel TNFR2 antibody induces T cell co- responses: an in vivo analysis. G. Qiao, M. Chen, stimulation and promotes durable anti-tumor immunity. M.J. Bucsek, H. Mohammadpour, C.R. MacDonald, J.F. Sampson, R.B. Fulton, V.B. Kurella, J.M. Richards, H.M. Campbell, B.L. Hylander and E.A. Repasky. Roswell A.J. Camblin, C.S. Wong, A. Koshkaryev, J.E. Lulo, Park Cancer Inst. J.A. Qiu, S. Kumar, L. Luus, Y. Jiao, J. Suchy, P1571 195.24 Precocious expression and engagement of S. Grabow, V. Paragas, M. Razlog, L. Xi, M. Muda, mature ab TCR in CD4-CD8- T cell progenitors can drive D.C. Drummond, E.M. Tam and A. Raue. Merrimack NOTCH1 mutation and T-ALL transformation. K.G. Laffey, Pharmaceuticals. R.J. Stiles, M. Ludescher, T.R. Davis, S.S. Khwaja, P1556 195.12 A pan-allele class I MHC prediction tool in mice R.J. Bram, P.J. Wettstein, V. Ramachandran, enables tumor immunology studies. C.I. DeVette, C.E. Johnson, R.D. Hammer, C-R. Shyu, D. Gil and M. Andreatta, A. Welm, M. Nielsen and W.H. Hildebrand. A.G. Schrum. Univ. of Missouri and Mayo Clin. Univ. of Oklahoma Hlth. Sci. Ctr., Univ. Nacional de San P1572 195.25 MyD88 dimerization inhibitors for targeting Mart´ın, Argentina, Univ. of Utah and Tech. Univ. of DenM., diffuse large B cell lymphomas. G.A. Snyder, L. Brown, Kgs. Lyngby, Denmark. C. Faupel, S. Taylor, M. Sherman, R. Beadenkopf, P1557 195.13 D42PD-1 inhibitor acts as a PD-1-independent J. Montague, K. Saikh and Y. Wang. Inst. of Human immunotherapy against human hepatocellular carcinoma. Virology, United States Army Med. Res. Inst. of Infectious Z. Tan, M.S. Chiu, C.W. Yan, X. Yang, Y.C. Wong, Dis. and China Pharmaceutical Univ., China. K. Man, A.S-L. Cheng and Z. Chen. Univ. of Hong Kong and Chinese Univ. of Hong Kong.

116 SUNDAY—POSTER SESSIONS

P1573 195.26 Repression of osteopontin by IRF8 regulates a P1622 196.2 Regulatory cell therapy for Sjogren¨ ’s syndrome novel immunosuppressive checkpoint. J.D. Klement, with E. coli colonization factor antigen I fimbriae. A. Akgul, A.V. Paschall, P.S. Redd, M.L. Ibrahim, C. Lu, D. Yang, A.S. Nelson, M. Maddaloni, C. Hoffman, B. Ella, J.R. Abbott, E. Celis, S.I. Abrams, K. Ozato and K. Liu. Augusta Univ., C. Nguyen and D.W. Pascual. Univ. of Florida. Roswell Park Cancer Inst. and NICHD, NIH. P1618 196.3 Combined PD-1 and LAG-3 blockade together P1574 195.27 The TNFR1/mTNFa signaling axis initiates with HLA-A*0201 epitopes immunotherapy restore the function + tumor-promoting inflammation and is associated with poor of CD8 TRM cells and reduce UV-B induced recurrent ocular outcome in neuroblastoma. J.A. Tomolonis, H. Ngai, herpes in HSV-1 infected “Humanized” HLA transgenic mice. A. Courtney and L.S. Metelitsa. Baylor Col. of Med. L. Benmohamed, P-G.A. Coulon, R. Srivastava and S. Roy. P1575 195.28 Examining the role of mouse Ly-6A as immune Univ. of California, Irvine. checkpoint inhibitor. B.D. Capozzoli, F. Mallon and P1611 196.4 Oral R848 reduces host susceptibility to enteric A.K. Bamezai. Villanova Univ. and Univ. of Pennsylvania. and systemic L. monocytogenes challenge. N. Kayraklioglu, P1576 195.29 Tumor-intrinsic PD-L1 regulates tumor B.H. Horuluoglu, M. Elango, A. Turan and D.M. Klinman. initiating cell virulence and stemness genes, and TCF1+ NCI, NIH. stem-like T cells through Raptor in ovarian cancer, which P1608 196.5 The damage-associated molecular pattern correlates with survival in high grade serous ovarian cancer. molecule cyclophilin A exerts mucosal adjuvanticity following H.B. Gupta, C.E. Murray, J. Deng, T.A.S. Mohammad, intranasal immunization in mice. A. Sen Chaudhuri and X. Zhang, B. Wu, C.A. Clark, G. Sareddy, Y. Chen, Z. Xiang. Hong Kong Polytechnic Univ., China. R. Vadlamudi, R. Li and T.J. Curiel. Univ. of Texas Hlth. P1628 196.6 CD40 ligand multi-trimer antigen fusion protein Sci. Ctr., San Antonio and George Washington Univ. (MagaVax) as a vaccine design for high-level CD8+ T cell P1577 195.30 Host genetic background affects response to responses. R.S. Kornbluth, C. Adase, V.S. Hamilton and immune checkpoint inhibitors in a B16 melanoma model using S. Studer. Multimeric Biotherapeutics, Inc. S diversity outbred mice. J. Hackett, C. McCarthy, M. Muniz, P1607 196.7 Designing pathogen-like particles to augment U A. Malysa, W. Wiesend and H. Gibson. Wayne State Univ. vaccine potency through the induction of broadened and N and Beaumont Hosp. synergistic innate immune responses. R. Toy, P. Pradhan, P1578 195.31 Monitoring PD-1 signaling in tumor infiltrating M.C. Keenum, N. Jhita, E. Blanchard, A. Atalis, N. Narang, lymphocytes. X. Bu, V.R. Juneja, K.M. Mahoney, C. Chukwu, G. Cortes, M.S. Suthar, P. Santangelo, C.G. Renolds, K.A. Mcguire, S. Maleri, P. Hua, B. Zhu, D. Shayakhmetov and K. Roy. Georgia Inst. of Technol. S.R. Klein, E. Greenfield, P. Armand, J. Ritz, A. Sharpe and Emory Univ. Sch. of Med. and G.J. Freeman. Dana-Farber Cancer Inst., Harvard-MIT P1624 196.8 Transduction of retinoic acid-inducible gene 1 Div. of Hlth. Sci. and Technol., Harvard Med. Sch., Dept. of by Ebola virus-like particles enhances antigen-presentation. Immunology, Harvard Med. Sch. and Harvard Med. Sch. and O. Martinez, M.K.E. Ngu, P. Warneke and B. burmeister. Brigham and Women’s Hosp. Winona State Univ. P1579 195.32 TSLP modulates anti-tumor Th2 immunity to P1626 196.9 Per oral inoculation with live or killed melanoma via regulation of the PD-L2/PD-1 axis. J-F. Lai, Chlamydia muridarum induces protection against per-vaginal L. Thompson and S.F. Ziegler. Benaroya Res. Inst. and Juno C. muridarum challenge. N. Shillova, S.E. Howe and Therapeutics. V.H. Konjufca. Southern Illinois Univ. P1600 195.33 The role of the PDL1-PD1 axis in modulating P1610 196.10 PLGA-encapsulated Chlamydia recombinant macrophage responses in the tumor microenvironment. MOMP enhances serum and mucosal Th1 antibodies F. Momen-Heravi. Columbia Univ. Med. Ctr. including memory and effector T-cells via subcutaneous P1601 195.34 PD1 blockade modulates Ca2+ fluxes in T cells prime-boost as compared to the intramuscular priming route of head and neck cancer patients. V.S. Gawali, A.A. Chimote, immunization of mice. R. Sahu, R. Verma, S. Dixit, M. Chirra, E. Janssen, T. Wise-Draper and L. Conforti. Univ. S. Duncan, A. Ipinmoroti, S.R. Singh and V.A. Dennis. of Cincinnati Col. of Med. and Cincinnati Children’s Hosp. Med. Alabama State Univ. Ctr. P1625 196.11 CD4 T Cells modulate the protective vs. P1603 195.35 Regulation of PD-L1 expression in stimulated pathologic response of CD8 T cells during viral infection. antigen specific CD8+ T cells by immunoglobulin 4. E. Luna. Arizona State Univ. P.M. Daftarian and W. Ouerkaxi. MBL International. P1627 196.12 Differences in T cell responses to Bordetella pertussis in adults as a function of whole cell versus acellular 196. CELLULAR AND MOLECULAR MECHANISMS childhood vaccination. R.F. da Silva Antunes, M. Babor, OF VACCINES FOR ENHANCING PROTECTIVE M. Pomaznoy, N. Khalil, M. Cortese, A.J. Mentzer, IMMUNE RESPONSES G. Seumois, C.D. Petro, L.A. Purcell, P. Vijayanand, S. Crotty, B. Pulendran, B. Peters and A. Sette. La Jolla Poster Session Inst. for Immunology, Stanford Univ. Sch. of Med., Wellcome Centre for Human Genet., Regeneron Pharmaceuticals, Inc. SUN. 2:30 PM—EXHIBIT/POSTER HALL and Regeneron Pharmaceuticals Inc. P1617 196.1 Randomized controlled phase 2a study results P1613 196.13 Prophylactic immunization prevents antiviral using anti IL-33 in food allergy. C. Liu, S. Chinthrajah, T cell subversion by a rat hepatitis C-like virus. A. Hartlage, A. Long, S-C. Lyu, M. Londei and K.C. Nadeau. Stanford S. Srinivasa Murthy, A. Kumar, S. Trivedi, P. Dravid, Univ. and AnaptysBio. H. Sharma, C.M. Walker and A. Kapoor. Nationwide Children’s Hosp.

117 SUNDAY—POSTER SESSIONS

P1606 196.14 Unraveling the mechanism of type-1 immunity P1630 196.27 Glycolipid-peptide vaccination induces liver- induction by defective viral genome-derived oligonucleotides. resident memory CD8+ T cells that protect against malaria. D.G. Fisher and C.B. Lopez. Univ. of Pennsylvania. L. Holz, Y.C. Chua, R.J. Anderson, S. Draper, B. Compton, P1620 196.15 The adjuvant effects of MF59 on antigen- J. Li, L. Kedzierski, Z. Wang, T. Osmond, K. Farrand, specific regulatory and effector T cells. P-H. Lin and P.J. Bertolino, D. Bowen, A. Cozijnsen, V. Mollard, H-C. Yang. Natl. Taiwan Univ. Col. of Med., Taiwan. G. McFadden, I. Caminschi, M. Lahoud, K. Kedzierska, P1609 196.16 Effects of high-affinity engineered class II- S.J. Turner, D. Godfrey, I. Hermans, G. Painter and restricted full-length and single-chain CAR-format T cell W.R. Heath. Univ. Melbourne, Australia, Victoria Univ. of receptors specific for a naturally occurring Listeria Wellington, Wellington, New Zealand, Monash Univ., monocytogenes epitope on T cell activation and specificity. Australia, Malaghan Inst. of Med. Res., New Zealand and D. Johnson, S. Myers, W. Magoffin, T. Orton, C.M. Tellez- Centenary Inst. of Cancer Med. and Cell Biol. Frietas, K. Christensen and K.S. Weber. Brigham Young P1631 196.28 A macrophage cell-therapeutic approach Univ. against multi-drug resistant infectious peritonitis. R. Tacke, P1623 196.17 Antigen-specific CD8 T cell response following J. Sun, S. Uchiyama, A. Polovina, J. Luker, V. Nizet and genital chlamydial challenge is a predictive biomarker of D. Nguyen. Cellular Approaches and Univ. of California, San vaccine efficacy in protection against reproductive tract Diego. pathology. A.K. Murthy, K. Warda, L. Moy, T. Musunuri, P1632 196.29 Immunization with Leishmania major centrin N. Bui, E. Wright-McAfee, K.H. Ramsey and W. Li. knock-out (LmCen-/-) parasites induces skin resident Midwestern Univ. memory T cells that plays a role in protection against wild P1605 196.18 Differential infection of dendritic cell subsets by type infection (LmWT). N. Ismail, S. Karmakar, virus-based vaccine platforms. C. Chiale and M.D. Robek. P. Bhattacharya, R. Dey and H.L. Nakhasi. Ctr. for Drug Albany Med. Col. Evaluation and Res., FDA. P1604 196.19 NKT cells induce IgG1 class switch against C. P1633 196.30 Raising endogenous anti-HMGB1 IgM difficile carbohydrate antigens and enhance immunity against antibody for athero-protection in the Apoe-/- mouse model of a live pathogen challenge. M.L. Lang, G.A. Lang, S.A. Amani, atherosclerosis. A. Hariharasubramanian, R. Elangovan, B. Shrestha, T. Shadid, A.F. Gillaspy and J.D. Ballard. Univ. A. Shankar, M. Giacobazzi, A. Broski, A. Panicker, of Oklahoma Hlth. Sci. Ctr. S. Shin, A. Chen and G. Zheng. Univ. of Illinois-Chicago. P1621 196.20 Targeting antigen to lymph node lymphatic endothelial cells under steady-state to promote archiving 197. HOW VIRUSES OVERRIDE THE and memory. C.D. Maulloo, D.S. Wilson, J.A. Hubbell and IMMUNE SYSTEM M.A. Swartz. Univ. of Chicago. P1615 196.21 Enhancement of antigen-specific responses Poster Session following protein vaccination by albumin-Flt3L expanded SUN. 2:30 PM—EXHIBIT/POSTER HALL dendritic cells: potential implications. D. Esquivel, B.K. Lam, B. Lee, M. Tan, T.C. Wu and C-F. Hung. Johns P1636 197.1 Alveolar macrophage dysfunction and Hopkins Univ. Sch. of Med. increased PD-1 expression during chronic SIV infection of P1616 196.22 Controlling germinal center affinity maturation rhesus macaques. R. Hunegnaw, Z. Mushtaq, to rare or hidden epitopes with antibodies. M. Meyer- G. Enyindah-Asonye, T. Hoang and M. Robert-Guroff. NIH. Hermann. Helmholtz Ctr. for Infection Res., Germany. P1662 197.2 HIV-induced production of CCL2 may promote P1619 196.23 Proteogenomic characterization of the specific rapid seeding of the latent HIV reservoir. T.A. Packard, antibody repertoire induced by gold nanoparticles of differing E. Herzig, X. Luo, J.H. Egedal, Z.W. Grimmett, shape and bioMolec. surface: toward the development of K.J. Hasenkrug, N. Roan and W.C. Greene. Gladstone nanoparticle-based vaccines. A. Perez-Potti,´ V. Giannone, Inst. of Virology and Immunology, Aarhus Univ., NIAID, NIH S. Lara, P. Bigini, K.A. Dawson and Y. Yan. Centre for and Univ. of California, San Francisco. BioNano Interactions, Ireland, Uppsala Biomedicinska P1651 197.3 Stochastic HIV gene expression is a novel Centrum, Sweden and Mario Negri Inst., Italy. mechanism for HIV persistence. R.A. Matus Nicodemos, P1614 196.24 Avian IgY antibodies recognize novel Dengue D. Douek and R. Koup. VRC, NIAID, NIH. NS1 epitopes with the ability to neutralize Dengue 2 virus P1635 197.4 NLRX1 facilitates HIV-1 infection of CD4 infection in vitro and in vivo. K.L. O’Donnell, D. Espinosa, T cells by promoting oxidative phosphorylation. H. Guo, M.L. Nilles, E. Harris and D. Bradley. Univ. of North Dakota Q. Wang, L. Wang, E. Rampanelli, X. Chen, S. Chanda, and Univ. of California, Berkeley. L. Su and J.P. Ting. Univ. of North Carolina, Chapel Hill, Univ. P1612 196.25 Evaluation of the safety profile of ssRNA of Amsterdam, The Netherlands and Sanford Burnham Prebys adjuvant derived from the IGR IRES region of CrPV. Med. Discovery Inst. H. Park, H-J. Kim, H.L. Ko, H.W. Kwak, D-H. Won, P1652 197.5 Sphingosine kinase 2 mediates LCMV- + D-B. Hwang, Y-S. Shin, J-W. Yun and J-H. Nam. Catholic induced CD4 T cell suppression and instigates viral Univ. of Korea, South Korea. persistence while preventing immunopathology. P1629 196.26 The inoculation of a-galactosylceramide and C.J. Studstill, C.J. Pritzl, Y-J. Seo, D.Y. Kim, C.Z. Xia, HPV18-E1 protein promote a cytokines profile involved in the J.J. Wolf, M. Vijayan and B. Hahm. Univ. of Missouri, generation of central memory CD8 + T cells. A. Amador, Columbia and Chung-Ang Univ. A.D. Gonzalez-Telona and M. Lizano. Instituto Nacional de P1634 197.6 A Brazilian Zika virus isolate suppresses type I Cancerolog´ıa, Mexico. interferon to establish a sustained infection in immunocompetent mice. R.D. Pardy and M.J. Richer. McGill Univ., Canada.

118 SUNDAY—POSTER SESSIONS

P1661 197.7 Impaired T cell activation resulting from IL-33 P1638 197.21 Interaction between HIV-1 integrase and viral induced myeloid derived suppressor cells and IL-10 secreting RNA drives proper virion morphogenesis and is necessary for Tregs is a major determinant of susceptibility to HSV1 infection successful infection. J.L. Elliott, J.E. Eschbach, of the central nervous system. R. Chandran, S. Mendonca D.Q. Lawson, M. Puray-Chavez, D. Townsend, W. Li, and EM. Cantin. City of Hope Beckman Res. Inst. P. Koneru, A.N. Engelman, M. Kvaratskhelia and P1656 197.8 Vaccinia virus E5 is a dominant inhibitor of the S.B. Kutluay. Washington Univ. Sch. of Med., Harvard Med. cytosolic DNA sensor cGAS. N. Yang, Y. Wang, S. Shuman Sch. and Univ. of Colorado Sch. of Med. and L. Deng. Memorial Sloan Kettering Cancer Ctr. P1639 197.22 Longitudinal analysis reveals a dynamic P1647 197.9 Age-dependent susceptibility to virus infection antibody repertoire response to Zika virus infection in is governed by host genetics. V.D. Menachery, convalescent human. F. Gao, X. Lin, L. He, R. Wang, E.T. McAnarney and M.T. Ferris. Univ. of Texas Med. Br., H. Wang, X. Shi, F. Zhang, C. Yin, L. Zhang, J. Zhu and Galveston and Univ. of North C.ina, Chapel Hill. L. Yu. Tsinghua University Sch. of Med., China, Scripps Res. P1653 197.10 High dimensional analysis of the GI tract as a Inst. and Eighth People’s Hosp., Guangzhou Med. Univ., long-term reservoir for chronic viral infection. B.L. Macleod, China. R. Dickson, K. Hezaveh, H.J. Elsaesser, C.J. Guidos and P1650 197.23 Filovirus glycoprotein glycosylation analysis D.G. Brooks. Princess Margaret Hosp., Canada and Hosp. and effects on immunogenicity. B. Martinez and For Sick Children, Canada. S. Bradfute. Univ. of New Mexico. P1655 197.11 New role of Epstein-Barr virus in pathogenesis P1660 197.24 In vivo effects of a4b7 blockade on size of viral of acute and chronic lymphocytic leukemia. V. Laurynenka, reservoirs in SIV-infected rhesus macaques. H. XU. Tulane M. Carter, S. Parameswaran, X. Chen, L.C. Kottyan, Natl. Primate Res. Ctr. M.T. Weirauch and J.B. Harley. Cincinnati Children’s Hosp. P1664 197.25 West-Nile virus replicon particles infect Med. Ctr. 293T cells expressing DC-SIGNR. O. Martinez, H. Kunkel S P1657 197.12 Adiposity augments toxicity of mouse and A. Ludwig. Winona State Univ. U cytomegalovirus. Z. Wang, C. Dunai, C. Le and P1665 197.26 Structural and functional insights of the capsid N W.J. Murphy. Univ. of California, Davis. protein from Zika virus. H. Song, Z. Shang, J. Qi and P1663 197.13 Axl promotes ZIKV entry and modulates G.F. Gao. Chinese Acad. of Sci., China. antiviral state of human Sertoli cells. D.P. Strange, B. Jiyarom, N. Pourhabibi Zarandi, X. Xie, H. Sadri- 198. IMMUNE RESPONSE TO Ardekani, P-Y. Shi and S. Verma. Univ. of Hawaii, Manoa, RESPIRATORY VIRUSES Wake Forest Sch. of Med. and Univ. of Texas Med. Br. P1637 197.14 Quantifying virus escape from T cells in the Poster Session latent HIV reservoir. J.A. Warren, S. Zhou, Y. Xu, M. Moeser, SUN. 2:30 PM—EXHIBIT/POSTER HALL J. Kirchherr, J. Sung, N. Roan, A. Adimora, J. Kuruc, fi C. Gay, D. Margolis, N. Archin, R. Swanstrom and P1675 198.1 A potently neutralizing site III-speci c human N. Goonetilleke. Univ. of North Carolina, Chapel Hill and antibody prevents human metapneumovirus replication in vivo. Univ. of California, San Francisco. J. Mousa, D. Diaz, J. Crabtree, A. Pena-Briseno, Y. Bar- P1648 197.15 A PML-synonymous mutation in MuPyV Peled and R.A. Tripp. Univ. of Georgia. + results in viral escape from a neutralizing monoclonal P1670 198.2 Uncharted territory: the CD4 T cell response antibody. M.D. Lauver, H. Ren, D. Goetschius, to human metapneumovirus. K.D. Lamens, M.C. Rogers, S. Hafenstein and A. Lukacher. Penn State Col. of Med. J.T. Tometich, T.W. Hand and J.V. Williams. Univ. of and Pennsylvania State Univ. Connecticut, Sch. of Med., Vanderbilt Univ. Sch. of Med. P1649 197.16 Evasion of humoral immunity by hepatitis E and Univ. of Pittsburgh Sch. of Med. virus. Z. Feng. The Res. Inst. at Nationwide Children’s Hosp. P1669 198.3 Respiratory syncytial virus strains differentially fl P1654 197.17 HIV-1 envelope glycan composition influences activate the in ammasome eliciting a pathogenic Th17 virus-host interaction. C.E. Hioe, M. Jan, R. Feyznezhad, response. K. Waldstein, K.A. Weiss, S. Hartwig, H. Quick, V. Itri, X. Liu and C. Upadhyay. Icahn Sch. of Med., Mount B. Poudel, P. Gurung and S.M. Varga. Univ. of Iowa. Sinai. P1679 198.4 Relative timing of type I interferon response P1659 197.18 Immunosignatures as a prognostic tool for and virus replication determines disease outcome during LCMV disease duration in mice. A. Tanveer, R. Antia, respiratory virus infection. R. Channappanavar, A. Fehr, S. Johnston, P. Stafford and J.N. Blattman. Arizona State J. Zheng, J. Abrahante, M. Mack, D. Meyerholz and Univ. and Emory Univ. S. Perlman. The Univ. of Tennessee Hlth. Sci. Ctr., Univ. of P1646 197.19 Daidzein and its analogs reactivate HIV Kansas, Carver Col. of Med., Univ. of Iowa, Univ. of Minnesota, replication from latently infected CD4 T cells. L. Liu, Univ. of Regensburg, Bavaria and Univ. of Iowa. J. Liang, X. Lu and Z. Chen. Univ. of Hong Kong. P1671 198.5 Can age-associated B cells contribute to anti- P1658 197.20 Whole genome evolutionary fingerprinting viral immunity? O.A. Kugler-Umana, Y. Kuang, W. Zhang, suggests novel primate gene functions in evolutionary arms P. Devarajan, J. Xia and S.L. Swain. Univ. of Massachusetts races. B.V. Tsu, B. Murrell, M. Daugherty and J. Wertheim. Med. Sch. Univ. of California, San Diego, Karolinska Inst., Sweden and P1667 198.6 Eosinophils undergo temporally regulated fl Sch. of Med., Univ. of California, San Diego. phenotypic and physiologic changes during in uenza A virus infection. A. Samarasinghe, M. Tiwary and K. LeMessurier. Univ. of Tennessee Hlth. Sci. Ctr.

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P1678 198.7 Lung-draining lymph-node-resident memory P1672 198.11 Respiratory syncytial virus disease severity is CD8 T cells mediate local protective immunity. associated with distinct CD8+ T cell profiles. D. Siefker, L. Vu, S.M. Anthony, N. Van Braeckel-Budimir, S. Moioffer, D. You, A. McBride, R. Taylor, T.L. Jones, J.P. DeVincenzo S.M. Hartwig, S.M. Varga, V.P. Badovinac and J.T. Harty. and S. Cormier. Louisiana State Univ., Univ. of Tennessee Carver Col. of Med., Univ. of Iowa. Hlth. Sci. Ctr. and Le Bonheur Children’s Hosp. P1674 198.8 Improved level and longevity of protective P1668 198.12 Differential gene expression profile analysis of immune responses in measles virus with efficient replication RIG-I- versus type I IFN-stimulated primary human nasal in blood and lymphoid tissue. W-H.W. Lin, R.J. Adams and epithelial cells and protection from influenza virus D.E. Griffin. Johns Hopkins Univ. Bloomberg Sch. of Publ. replication. E. Hartmann, V. von Lilien Waldau, Hlth. and Johns Hopkins Univ. Sch. of Med. J.P. Stumpel,¨ J. Ludwig, M. Schlee, C. Coch and P1673 198.9 The role of exchange proteins directly G. Hartmann. Clin. for Otorhinolaryngology, Head and Neck activated by cAMP in respiratory syncytial virus-induced Surgery, Univ. of Bonn, Germany and Univ. of Bonn, Germany. pulmonary pathogenesis. E-J. Choi, J. Ren, W. Wu, P1677 198.13 Unveiling the functional role of hsa-miR-4634 R.P. Garofalo and X. Bao. Univ. of Texas Med. Br. in the innate immunity against respiratory pneumovirus P1676 198.10 Immunoprotection versus immunopathology infection. I.K. Uche and M.A. Guerrero-Plata. Louisiana by type I and III interferon against human metapneumovirus. State Univ. Y. Zhang, J. Xu, M. Miranda-Katz, H.E. Rich, M.L. Manni, P1666 198.14 The influence of the lung virome on pulmonary S. Tollefson, S.N. Sarkar, J.F. Alcorn and J. Williams. Univ. B cells. F. Aihara, M.P. Breen, F. Feng, R. Fearns, of Pittsburgh Sch. of Med., Tsinghua Univ. Sch. of Med., China, J.P. Mizgerd and T.B. Kepler. Boston Univ. Sch. of Med. Children’s Hosp. of Pittsburgh, Univ. Pittsburgh Med. Ctr. and Vanderbilt Univ.

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MAY 13

199. MAJOR SYMPOSIUM G: IMMUNE RESPONSES 201. THE INTERNATIONAL SOCIETY FOR TO EMERGING VIRAL INFECTIONS NEUROIMMUNOLOGY (ISNI) SYMPOSIUM: – Major Symposium FRONTIERS IN NEUROIMMUNOLOGY SOMETHING FOR EVERYONE MON. 8:00 AM—BALLROOM 20D Guest Society Symposium CHAIRS: J. CROWE, JR., S. CHERRY MON. 8:00 AM—ROOM 30AB 8:00 Human B cell responses to emerging viral infections. J. Crowe, Jr. Vanderbilt Univ. CHAIRS: A. BAR-OR, N. ARBOUR 8:35 Using functional genomics to reveal new facets of 8:00 Innate immune mechanisms of synapse remodeling antiviral immunity. S. Cherry. Univ. Pennsylvania. during brain development and learning. 9:10 Breaking and entering: viral infections of host barrier A. Molofsky. Univ. California, San Francisco. surfaces. C.B. Coyne. Univ. of Pittsburgh. 8:40 Regulation of CNS inflammation by astrocytes. 9:45 Broad and potent neutralization of Ebola and Lassa: F. Quintana. Harvard Univ. insights from structural biology. E.O. Saphire. 9:20 How CNS microenvironments shape CNS cell/immune Scripps Res. Inst. cell crosstalk. J. Goverman. Univ. of Washington. 10:20 Immune determinants of severe influenza virus infection. A. Garcia-Sastre. Icahn Sch. of Med., 202. ANTIGEN PROCESSING AND PRESENTATION II Mount Sinai. M 10:55 Adaptive immune response to Dengue and Zika: Block Symposium protection or pathogenesis? S. Shresta. La Jolla O MON. 8:00 AM—ROOM 26AB Inst. for Immunology. N CHAIRS: L. SANTAMBROGIO, K. HASTINGS 200. MAJOR SYMPOSIUM H: REGULATING IMMUNE 8:00 Gettinginthegroove:editingofMHC-Iantigenrepertoires CELL METABOLISM TO REGULATE by molecular chaperones is governed by a network of IMMUNE RESPONSES protein dynamics. N. Sgourakis, A. McShan, K. Natarajan, J. Jiang, J. Park, S. Overall, Major Symposium J.S. Toor, V. Kumirov, D. Flores-Solis, MON. 8:00 AM—BALLROOM 20BC M. Badstubner, E.L. Kovrigin, C.R. Bagshaw, J. Pallesen, E. Procko and D.H. Margulies. Univ. CHAIRS: J.D. POWELL, L. MOREL of California, Santa Cruz, NAIAD, NIH, Univ. of Illinois, 8:00 mTOR links TCR engagement with metabolic Urbana-Champaign, Marquette Univ. and Indiana reprogramming to regulate T cell activation, Univ. (177.31) differentiation, and function. J.D. Powell. Johns 8:15 Molecular mechanisms underlying the glycation Hopkins Univ. induced-impairment of antigen processing and 8:42 Metabolic regulation of autoimmunity in lupus. L. Morel. presentation in diabetic (T2DM) patients and ob/ob Univ. of Florida. mice. L. Santambrogio, C. Clement, M.P. Negroni, 9:24 Itaconate immunology - from one cell to many. P. Nanaware, K. Morozova and L. Stern. Albert M.N. Artyomov. Washington Univ. Sch. of Med. in Einstein Col. of Med. and Univ. of Massachusetts St. Louis. Med. Sch. (177.21) 10:06 Improving immunotherapy of cancer through metabolic 8:30 Parkinson’s disease-related proteins PINK1 and Parkin reprogramming. G.M. Delgoffe. Univ. of Pittsburgh. are major regulators of the immune system. 10:48 Non-canonical autophagy mediates the D. Matheoud, T. Cannon, A. Voisin, immunometabolic program. J. Martinez. NIEHS, A-M. Penttinen, L. Ramet, A. Fahmy, C. Ducrot, NIH. A. Laplante, M-J. Bourque, L. Zhu, A. Le Campion, H. McBride, S. Gruenheid, L-E. Trudeau and M. Desjardins. Ctr. de Recherche du Ctr. Hosp., IMMUNOLOGY 2020TM Canada, McGill Univ., Canada and Universitede´ May 8 – 12, 2020 Montreal,´ Canada. (177.27) Honolulu, HI 8:45 The human NK cell receptor KIR2DS4 detects a We will open the Abstract Submission site in conserved bacterial epitope presented by HLA-C. early November and Registration in mid-December 2019. E.O. Long and M.J.W. Sim. Natl. Inst. of Allergy For updates, go to www.immunology2020.org. and Infectious Dis. (177.24)

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9:00 Wdfy4-deficiency reveals a critical role for cross- 9:45 Lung-migratory dendritic cells traffic into the spleen after presentation in anti-viral and anti-tumor responses. influenza virus infection. M.M. Jenkins, H. Bachus, D.J. Theisen, J.T. Davidson, C.G. Briseño, B. Leon-Ruiz and A. Ballesteros-Tato. Univ. of M. Gargaro, E.J. Lauron, Q. Wang, P. Desai, Alabama at Birmingham, Sch. of Med. (56.18) V. Durai, P. Bagadia, J.R. Brickner, W.L. Beatty, H.W. Virgin, W.E. Gillanders, N. Mossamaparast, 204. B CELL IMMUNITY M.S. Diamond, .D. Sibley, W. Yokoyama, R.D. Schreiber, T.L. Murphy and K.M. Murphy. Block Symposium Washington Univ. in St. Louis, Univ. of Perugia, Vir MON. 8:00 AM—ROOM 31ABC Biotechnology and HHMI. (177.23) 9:15 Investigating a role for HLA-DO in the development of CHAIRS: P. CASALI, L. JUSTEMENT CD4 memory cells. N. Song, R.A. Welsh and 8:00 The bona fide structure of IgM pentamer and its binding S. Sadegh-Nasseri. Johns Hopkins Univ. (177.25) mode with AIM/CD5L molecule. T. Miyazaki, 9:30 The non-classical MHC-II molecule H2-O (DO) is E. Hiramoto and S. Arai. Univ. of Tokyo, Japan. required for efficient recovery from influenza A (123.3) infection. L. Stern and M.M. Jurewicz. Univ. of 8:15 APRIL signaling in human antibody secreting cells Massachusetts Med. Sch. (177.28) promotes cellular response via p38 and differential immediate early gene regulation. S.J. Stephenson, 203. T CELL REGULATION AND FUNCTION M.A. Care, G.M. Doody and R.M. Tooze. Univ. of Leeds, United Kingdom. (123.7) Block Symposium 8:30 CD28 regulates autophagy to enhance plasma cells MON. 8:00 AM—ROOM 33ABC survival. P. Peng, C. Chavel, A. Utley, L. Carlson and K.P. Lee. Roswell Park Cancer Inst. (123.11) CHAIRS: C. KEMPER, S. JAMESON 8:45 Integrative analysis of human memory B cell coding and 8:00 Metabolic shift induced by systemic activation of T cells non-coding transcriptomes. J.B. Moroney, in PD-1-deficient mice perturbs brain monoamines A. Vasudev, J.R. Taylor, H. Zan, A. Pertsemlidis and emotional behavior. M. Miyajima, B. Zhang, and P. Casali. Univ. of Texas Long Sch. of Med., M. Guerrini, Y. Sugiura and S. Fagarasan. UTHealth, San Antonio. (123.14) RIKEN, Japan, Keio Univ. Sch. of Med., Japan and 9:00 TET enzymes augment AID expression via 5hmC Ctr. for Integrative Med. Sci., RIKEN. (56.2) modifications at the Aicda superenhancer. 8:15 Antigen presentation by CD301b+ dermal dendritic cells C-W.J. Lio, V. Shukla, D. Samaniego-Castruita, dictates CD4+ T cell fate. N. Tatsumi, A. Iwasaki and E. Gonzalez Avalos, A. Chakraborty, X. Yue, Y. Kumamoto. Rutgers New Jersey Med. Sch. and D.G. Schatz and A. Rao. La Jolla Inst. for HHMI. (56.9) Immunology and Yale Univ. Sch. of Med. (123.15) 8:30 You are what you eat: CD46 regulated amino acid 9:15 Effects of antiorthostatic suspension, tetanus toxoid, usage dictates T cell function. E.E. West, and CpG on the bone marrow antibody repertoire S. Freeley, M.M. Kaminski, S. Veenbergen, in C57BL/6 mice. T.A. Rettig, N.C. Nishiyama, D-Y. Lee, L. St. John-Williams, J.W. Thompson, M.J. Pecaut and S.K. Chapes. Loma Linda Univ. D.R. Green, S. Scholl-Buergi, D. Karall, M. Huemer and Kansas State Univ. (123.6) and C. Kemper. NHLBI, NIH, Kings Col. London, 9:30 Physiological V(D)J recombination is mediated by RAG United Kingdom, St. Jude Children’s Res. Hosp., scanning of loop-extruded chromatin. Y. Zhang, Erasmus Univ. Med. Ctr., The Netherlands, Duke X. Zhang, Z. Liang, Z. Ba, E. Dring, J. Zurita, Univ., Med. Univ. of Innsbruck, Austria and Univ. A.P. Aiden, E.L. Aiden and F.W. Alt. Western Children’s Hosp., Zurich, Switzerland. (56.10) Michigan Univ. Homer Skryker Sch. of Med., 8:45 Rapid activation of brain resident memory T cells Boston Children’s Hosp. and Baylor Col. of Med. following neurological insults. K. Ayasoufi, (123.18) S. Namen, E. Goddery, Z. Tritz, C.E. Fain, 9:45 Tumor necrosis factor receptor associated factor 3 L. Yokanovich, F. Jin and A.J. Johnson. Mayo regulates B cell antigen receptor signaling. Clin., Mayo Clin. Grad. Sch. of Biomed. Sci. and A.L. Whillock and G.A. Bishop. Univ. of Iowa Mayo Clin., Rochester, Minnesota. (56.20) Carver Col. of Med. (123.2) 9:00 The costimulatory molecule ICOS promotes establishment of resident memory CD8+ T cells. REMINDER C. Peng, H. Borges da Silva, H. Wang and S. Jameson. Univ. of Minnesota. (56.13) 9:15 Secondary stimulation of CD4 T cells generates an exhaustion phenotype. G.S. Wolf and N.J. Singh. Univ. of Maryland, Baltimore. (56.14) 9:30 PD-1 regulates response to bystander activation of memory CD8 T cells. C. Le, C. Dunai, L.T. Khuat and W.J. Murphy. Univ. of California, Davis. (56.17)

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205. MUCOSAL IMMUNITY DURING INFECTION 206. TECHNOLOGICAL INNOVATIONS I Block Symposium Block Symposium

MON. 8:00 AM—ROOM 25ABC MON. 8:00 AM—ROOM 32AB

CHAIRS: M. ABT, J. MIZGERD CHAIRS: Y. SYKULEV, A.M. BURKHARDT 8:00 Identification and characterization of lung commensal 8:00 Pressure enabled drug delivery of anti-CEA CAR-T cells bacteria that modulate immune response in increases intra-hepatic CAR-T tumor penetration and tuberculosis. L. Bernard, A. Colom, M. Cescato, therapeutic index in a murine model of liver C. Cougoule, P. Guilloton, N. Ghebrendrias, metastasis. J.C. Hardaway, L.F. Chai, M. Lopes, F. Capilla, A. Alloy, A. Remot, M. Thomas, B. Rabinowitz, P. Guha, D. Jaroch, B. Cox, P. Langella, O. Neyrolles and G. Lugo-Villarino. R. Knight, J. Zeldis, N.J. Espat and S.C. Katz. Institut de Pharmacologie et de Biologie Structurale, Roger Williams Med. Ctr., TriSalus Life Sci., Inc. France, Centre de Physiopathologie de Toulouse and Sorrento Therapeutics, Inc. (130.1) Purpan, France and INRA, France. (66.2) 8:15 Use of modified peptides for live tracking of peptide- 8:15 Inducible epithelial resistance protects against acute MHCII complexes during antigen-specific T cell- viral infection and subsequent CD8+T cell dendritic cell interactions. J.A. Al Souz, dependent lethal immunopathology. S. Wali, M. Akkaya, R. Kamdar, O. Kamenyeva, J. Kabat, J.R. Flores, D. Goldblatt, M. Tuvim, B.F. Dickey E.M. Shevach and B. Akkaya. NIAID, NIH and Univ. and S.E. Evans. Univ. of Texas MD Anderson of Maryland, Baltimore County. (130.2) Cancer Ctr. (66.3) 8:30 Comprehensive benchmarking of T-cell epitope 8:30 CD4+ resident memory T cells dominate prediction tools. S. Paul and B. Peters. La Jolla immunosurveillance and orchestrate local recall Inst. for Allergy and Immunology. (130.3) responses. L.K. Beura, N.J. Fares-Frederickson, 8:45 High throughput pMHC-I multimer library production E.M. Steinert, M.C. Scott, E.A. Thompson, using chaperone-mediated peptide exchange. K.A. Fraser, J.M. Schenkel, V. Vezys and S. Overall, J.S. Toor, M. Yarmarkovich, S. Hao, D. Masopust. Univ. of Minnesota, Feinberg Sch. of S. Nguyen, A. Sada-Japp, M.R. Betts, J.M. Maris, M Med., Northwestern Univ., Ctr. for Immunology, Univ. P. Smibert and N.G. Sgourakis. Univ. of California, O of Minnesota and Bluebird Bio. (66.21) Santa Cruz, Children’s Hosp. of Philadelphia, New N 8:45 T-cell derived acetylcholine aids host defenses during York Genome Ctr. and Inst. for Immunology, enteric bacterial infection with Citrobacter rodentium. Perelman Sch. of Med., Univ. of Pennsylvania. V.T. Ramirez, I. Brust-Mascher, M.B. Gardner, (130.4) J.A. Sladek, M.G. Gareau and C. Reardon. Univ. 9:00 Imaging cancer immunology: tracking immune cells in of California, Davis, Sch. of Vet. Med. (66.16) vivo with magnetic particle imaging. J. Gaudet, 9:00 Unrelated respiratory infections compromise J. Mansfield and P. Goodwill. Magnetic Insight. established cellular immunity by promoting (130.7) apoptosis of pre-existing lung-resident memory 9:15 Development of sialoglycan recognizing probes with CD8 T cells. S.L. Hayward, Z.R.T. Li, J.L. Lobby, defined specificities: towards exploring the dynamic J.O.P. Eggert and J.E. Kohlmeier. Emory Univ. Sch. mammalian sialoglycome. S. Srivastava, of Med. (66.17) A. Verhagen, B. Wasik, H. Yu, A. Sasmal, 9:15 Acetylcholine and cholinergic lymphocytes in the B. Bensing, N. Khan, Z. Khedri, S. Diaz, immune response to influenza. J.A. Phillips, P. Sullam, N. Varki, X. Chen, C. Parrish and A. Horkowitz and R. Feuer. San Diego State A. Varki. Sch. of Med., Univ. of California, San Univ. (66.20) Diego, Col. of Vet. Med., Cornell Univ., Univ. of 9:30 Repeated respiratory bacterial exposures elicit lung- California, Davis and Sch. of Med., Univ. of resident memory B cells in the absence of California, San Francisco. (130.5) organized tertiary lymphoid tissue. K.A. Barker, 9:30 Genome-wide CRISPR wcreens in primary human N.M. Smith, A.T. Shenoy, I.M.C. Martin, T cells reveal key regulators of immune function. M.R. Jones, L.J. Quinton and J.P. Mizgerd. E. Shifrut, J. Carnevale, A. Ashworth and Boston Univ. Sch. of Med. (66.22) A. Marson. Univ. of California, San Francisco. 9:45 Host immunity modulates efficacy of fecal microbiota (130.6) transplantation treatment of Clostridium difficile 9:45 20,000 layers under the model: Bayesian neural infection. M.C. Abt, E4.G. Pamer, E.R. Littmann, networks improve the robustness of human PBMC I. Zarin and R.A. Carter. Perelman Sch. of Med., classifications using immunologist-encoded bias. Univ. of Pennsylvania and Mem. Sloan Kettering M.A. Velazquez-palafox, I.J. Taylor, J. Spidlen, Cancer Ctr. (66.8) J. Lai, R. Halpert and M. Stadnisky. Flowjo and BD Biosciences. (130.29)

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207. TRANSLATIONAL ADVANCES IN TISSUE 8:15 Enhanced antitumor effects by combining IL-12 gene SPECIFIC AUTOIMMUNITY electrotransfer with anti-PD1 in preclinical metastatic cancer model. G. Shi, C. Lundberg, M. Scott, Block Symposium C. Edelblute and R. Heller. Old Dominion Univ. MON. 8:00 AM—ROOM 30CDE (136.2) 8:30 CD122-selective IL-2 complexes synergize with anti- CHAIRS: L. SOLT, R. AXTELL PD-L1 in B16 melanoma to treat PD-L1KO tumors, 8:00 Genetic and pharmacological modulation of RORa possibly through inducing CD8+TCF-1+Tim3-PD-1+ + regulates TH17-driven inflammatory disorders. CXCR5 stem-like T cells. X. Zhang, J.M. Drerup, L.A. Solt, R. Wang, M. Amir, S. Chaudhari, J. Mendez, A.S. Padron, Y. Deng, H.B. Gupta and S. Campbell, M.B. Bassette, A. Eliason, T.J. Curiel. First Affiliated Hosp., Sun Yat-sen Univ., M.S. Sundrud and T. Kamenecka. Scripps Res. China and UTHealth, San Antonio. (136.3) Inst. (68.11) 8:45 Increasing intratumoral dendritic cells to potentiate anti- 8:15 IFN-b induces IL-6 production by B cells to promote tumor effects of Newcastle disease virus-based TH17-mediated neuroinflammation. A.M. Agasing, immunotherapy. J. Svensson-Arvelund, S. Gawde, N. Siebert, K. Ruprecht, F. Paul and S. Cuadrado-Castano, L. Hammerich, M. Yellin, R.C. Axtell. Oklahoma Med. Res. Fndn. and Charite´ H. Marsh, B.D. Brown, A. Garc´ıa-Sastre and – Universitatsmedizin¨ Berlin, Germany. (68.12) J. Brody. Icahn Sch. of Med., Mount Sinai and 8:30 Human CD39 overexpression or APT102 recombinant Celldex Therapeut. (136.4) apyrase administration enhances Treg and Tr1 cell 9:00 Immunodominant and cryptic tumor neoantigen-specific immunity in inflammatory bowel disease. M. Vuerich, immune responses activated by an armed oncolytic R.J. Robles, S. Mukherjee, A. Xie, R. Harshe, virus expressing a PD-L1 inhibitor . G. Wang. Univ. of A.C. Moss, S.C. Robson and M.S. Longhi. Beth Southern California. (136.5) Israel Deaconess Med. Ctr. (68.13) 9:15 Influenza vaccination administered in the tumor induces 8:45 Anti-CD4/CD8 antibody therapy induces Foxo1 an inflamed tumor microenvironment and reduces transcriptional activity promoting T cell egress from tumor growth. J.H. Newman, B. Chesson, inflamed tissue during type 1 diabetes. M.P. Clark, N. Herzog, P. Bommareddy, S. Aspromonte, C. Kroger, A. Martin and R. Tisch. Univ. of North R. Pepe, R. Estupinian, M. Aboelatta, Carolina, Chapel Hill. (68.14) S. Buddhadev, J. Schenkel, P. Thomas, 9:00 Lipid nanoparticle-mediated delivery of enhanced J. Rudra, A. Silk and A. Zloza. Rutgers Cancer costimulation blockade to prevent type 1 diabetes. Inst. of New Jersey, Univ. of Texas MD Anderson Y. Zhang, J. Wang, X. Calderon-Colon, Cancer Ctr., Massachusetts Inst. of Technol., St. O.N. Tiburzi, M. Iglesias Lozano, J.B. Patrone Jude Children’s Res. Hosp., Washington Univ., St. and G. Raimondi. Johns Hopkins Univ. (68.15) Louis, Harvard Med. Sch. and Rush Univ. Med. Ctr. 9:15 ST8Sia6 generated a2,8-disialic acids mitigate (136.6) hyperglycemia in multiple low dose streptozocin- 9:30 Activation of human immune cells with cowpea mosaic induced diabetes. P. Belmonte, M. Shapiro, virus. M.M. Albakri, V. Beiss, S.N. Fiering, S. McCue, M. Rajcula and V. Smith Shapiro. N.F. Steinmetz and S.F. Sieg. Case Western Mayo Clin. (68.16) Reserve Univ., Univ. of California, San Diego and 9:30 Alpha-synuclein acts as an alarmin to promote dendritic Dartmouth Geisel Sch. of Med. (136.7) cell activation and proinflammatory immune 9:45 Cold ...isnotsocold: CD4+ T cells are active but response. M.M. Alam, D. Yang, A.L. Trivett, suppressed in colorectal cancer. J.M. Jessup. Inova X-Q. Li and J.J. Oppenheim. NCI, NIH. (68.17) Schar Cancer Inst. (136.8) 9:45 Restoring the balance in autoimmunity: the promise of IL-2 mutein. L. Khoryati, M. Nguyet Pham, 209. NATIONAL INSTITUTE OF ARTHRITIS AND M. Sherve, S. Kumari, M. Bogdani, MUSCULOSKELETAL AND SKIN DISEASES D.J. Campbell and M. Gavin. Benaroya Res. Inst. (NIAMS) SYMPOSIUM: SINGLE CELL (68.20) DECONSTRUCTION OF RHEUMATOID SYNOVIUM AND LUPUS KIDNEY BY THE 208. COMBINATION THERAPIES RA/SLE ACCELERATING MEDICINES FOR IMMUNO-ONCOLOGY PARTNERSHIP (AMP) NETWORK Block Symposium NIH-Sponsored Session MON. 8:00 AM—ROOM 29ABCD MON. 10:15 AM—ROOM 26AB CHAIRS: E. STONE, C. FLORES CHAIRS: J. ANOLIK, M. BRENNER 8:00 Inhibition of SHP-1 expands the repertoire of anti-tumor 10:15 AMP approach and what we have learned about RA T cells available to respond to checkpoint blockade synovial pathotypes. J. Anolik. Univ. of Rochester. therapy. J. Snook, A. Soedel and M.A. Williams. 10:39 The immune landscape in the RA synovium. Univ. of Utah. (136.1) S. Raychaudhuri. Brigham and Women’s Hosp. 11:03 The stromal cell landscape in the RA synovium from single cell analysis. M. Brenner. Brigham and Women’s Hosp.

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11:27 New insights into renal resident cells from the AMP 211. T CELL RECEPTOR SIGNALING Lupus Nephritis cohort. C. Putterman. Albert Block Symposium Einstein Col. of Med. 11:41 The immune cell landscape in lupus nephritis kidneys. MON. 10:15 AM—ROOM 31ABC P. Hoover. Broad Inst. CHAIRS: A. SNOW, T-H. TAN 210. BASIC AUTOIMMUNITY: ROLE OF MICROBES 10:15 GTPase-activating protein (RASAL1) associates with ZAP-70 of the TCR and negatively regulates T cell Block Symposium proliferation and anti-tumor immunity. C.E. Rudd, MON. 10:15 AM—ROOM 32AB Y.R. Thaker, M. Raab and K. Strebhardt. Univ. de Montreal, Canada, Univ. of Essex, United CHAIRS: P. KENDALL, A. MANGALAM Kingdom, J.W. Goethe Univ., Germany and W.T. 10:15 Aberrant MDA5 signaling and IFN-b synthesis elicit Goethe Univ., Germany. (184.4) protection from coxsackievirus-accelerated type 1 10:30 Signaling from individual opioid receptors differentially diabetes. S.I. Blum, A.R. Burg, Y-G. Chen and modulates the functional and phenotypic potential of H.M. Tse. Univ. of Alabama, Birmingham and Med. resting and activated human CD8+ T cells. Col. of Wisconsin. (178.7) C. Mazahery, S. Valadkhan and A.D. Levine. 10:30 A single infection with a malaria parasite protects mice Case Western Reserve Univ. (60.8) from lethal autoimmune glomerulonephritis. L. Amo, 10:45 CCDC134 facilitates T cell activation and inflammatory H.K. Kole, B. Scott, I.N. Moore, C-F. Qi, J. Wu, responses by regulating T cell receptor signaling. H. Wang and S. Bolland. NIAID, NIH and J. Huang, T. Zhang, B. Yu, S. Yin and X. Qiu. Comparative Med. Branch, Infectious Dis. Sch. of Basic Med. Sci., Peking Univ. Hlth. Sci. Pathogenesis Section, NIAID, NIH. (178.2) Ctr., China. (186.5) 10:45 Dysbiosis reprograms the differentiation of thymus- 11:00 JNK inhibition by transforming growth factor-b type I derived regulatory T cells. K. Wang, B-H. Yang receptor (TGF-b RI) in T cells. R. Jacks and and W. Fu. Univ. of California, San Diego. (178.16) M. Iwashima. Loyola Univ. Chicago. (184.9) 11:00 Induction of regulatory B cells by bacterial DNA in the 11:15 T-cell signaling in Th17-mediated inflammation. M gut microbiota at early age is beneficial in lupus-prone T-H. Tan and H-C. Chuang. Natl. Hlth. Res. Inst., O mice. Q. Mu, B. Swartwout, X. Cabana-Puig, Taiwan. (124.7) N J. Grieco, T.E. Cecere and X.M. Luo. Virginia 11:30 Molec. background of Orai1 accumulation in the Tech. (178.11) immunological synapse. Or. Vor¨ os,¨ G. Panyi and 11:15 B cells, bugs, bowels, and bones: Bruton’s tyrosine P. Hajdu. Fac. of Med., Univ. of Debrecen, Hungary kinase deficiency alters gut B lymphocyte and Fac. of Dentistry, Univ. of Debrecen, Hungary. populations and IgA recognition of commensal (184.3) bacteria in autoimmune arthritis. R. Bonami, 11:45 TMEM16F regulates bystander TCR-CD3 membrane C. Thurman, L. Nyhoff, B. Barron and binding at the immunological synapse. A. Connolly, P.L. Kendall. Vanderbilt Univ. Med. Ctr. (178.17) R. Panes,` A. Bellemare-Pelletier and E. Gagnon. 11:30 Interactions between the host genome and the gut Univ. of Montreal, Canada. (184.7) microbiome determine susceptibility to CNS 12:00 FOXP3, CD48, and autophagy confer the protection of autoimmune disease. T.L. Montgomery, Q. Fang, CD4 and CD8 human T cells from T cell receptor A. Kunster,¨ H. Busch, C. Teuscher and restimulation-induced cell death. K. Voss, N.M. Lott, D. Krementsov. Univ. of Vermont and Univ. of C. Lake, B.M. Bauman, B. Dorjbal, C.R. Luthers, Lubeck,¨ Germany. (178.3) S. Arjunaraja, C.L. Dalgard and A.L. Snow. 11:45 Linking diet, gut microbiota and autoimmunity: a Uniformed Serv. Univ. of the Hlth. Sci. (184.5) phytoestrogen diet alters the gut microbiota and influences experimental autoimmune 212. REGULATORY MECHANISMS encephalomyelitis (EAE). S.N. Freedman, Block Symposium S. Shahi, K. Zarei, A. Gupta, N. Guseva, A. Bossler, K.L. Legge and A.K. Mangalam. MON. 10:15 AM—ROOM 30AB Carver Col. of Med. Univ. of Iowa and Dept. of CHAIRS: J. LUKENS, E. ZUNIGA Pathology, Univ. of Iowa. (178.13) 12:00 IL-17A control CNS inflammatory disease by regulating 10:15 Dysregulation of lipid metabolism during gram-negative Treg cells through modulation of gut microbiota in sepsis in Mkp-1 deficient mice. A.J. Batty, J. Li, HLA class-II transgenic mice model of multiple X. Wang, W.E. Ackerman, S.G. Kirk, W.M. White, sclerosis (MS). S.K. Shahi, S.N. Freedman, X. Wang, D. Anastasakis, L. Samavati, A.C. Murra, K. Zarei, N.V. Guseva, K.G. Corley, I. Buhimschi, L.D. Nelin, M. Hafner and Y. Liu. A. Bossler, N.J. Karandikar and A.K. Mangalam. Nationwide Children’s Hosp., NIH, NIAMS, NIH and Carver Col. of Med., Univ. of Iowa. (178.14) Ctr. for Molec. Med. and Genet. (187.2) 10:30 The ssDNA exonucleases PLD3 and PLD4 are required to prevent lethal primary HLH-like disease in mice. A.L. Gavin, D. Huang and D. Nemazee. Scripps Res. Inst. (187.6)

125 MONDAY—AM

10:45 Key roles for the innate immune response to genotoxic 10:15 Regulatory cell therapy for Sjogren¨ ’s syndrome with E. stress in neurological disease. J.R. Lukens, coli colonization factor antigen I fimbriae. A. Akgul, C.E. Bellinger, E.L. Frost, M.E. Shaw, A.C. Bolte A.S. Nelson, M. Maddaloni, C. Hoffman, B. Ella, and C.R. Lammert. Univ. of Virginia. (187.7) J.R. Abbott, C. Nguyen and D.W. Pascual. Univ. of 11:00 Deciphering liver environmental signaling pathways for Florida. (196.2) Kupffer cell identity. M. Sakai, T.D. Troutman, 10:30 CD40 ligand multi-trimer antigen fusion protein J.S. Seidman, Z. Ouyang, N.J. Spann, Y. Abe, (MagaVax) as a vaccine design for high-level K. Ego, C.M. Bruni, J.C.M. Schlachetzki, A. Nott, CD8+ T cell responses. R.S. Kornbluth, H. Bennett, J. Chang, B.C.T. Vu, M. Pasillas, C. Adase, V.S. Hamilton and S. Studer. V.M. Link, L. Texari, S. Heinz and C.K. Glass. Multimeric Biotherapeutics, Inc. (196.6) Univ. of California, San Diego. (187.21) 10:45 Designing pathogen-like particles to augment vaccine 11:15 Loss of miR-146a skews the dendritic cell milieu in favor potency through the induction of broadened and of CD8a+CD103+ cross-presenting migratory synergistic innate immune responses. R. Toy, dendritic cells and reduces production of IL-27. P. Pradhan, M.C. Keenum, N. Jhita, P.A. Flynn and E.F. Lind. Oregon Hlth. & Sci. E. Blanchard, A. Atalis, N. Narang, C. Chukwu, Univ. (187.29) G. Cortes, M.S. Suthar, P. Santangelo, 11:30 Chronic viral infection induces metabolic reprograming D. Shayakhmetov and K. Roy. Georgia Inst. of of plasmacytoid dendritic cells. T.T. Greene, Y. Jo Technol. and Emory Univ. Sch. of Med. (196.7) and E. Zuniga. Univ. of California, San Diego. 11:00 Per oral inoculation with live or killed Chlamydia (187.28) muridarum induces protection against per-vaginal 11:45 MCMV-experienced ILC1 acquires an m12-dependent C. muridarum challenge. N. Shillova, S.E. Howe memory response. T.E. O’Sullivan, O-E. Weizman, and V.H. Konjufca. Southern Illinois Univ. (196.9) J.R. Carlyle and J.C-Y. Sun. David Geffen Sch. of 11:15 CD4 T Cells modulate the protective vs. pathologic Med., Univ. of California, Los Angeles, Mem. Sloan response of CD8 T cells during viral infection. Kettering Cancer Ctr. and Univ. of Toronto. (187.8) E. Luna. Arizona State Univ. (196.11) 12:00 A role for allosteric disulfides in regulating the function of 11:30 Differential infection of dendritic cell subsets by virus- human killer cell receptor KIR2DL4. S. Rajagopalan, based vaccine platforms. C. Chiale and M.D. Robek. G. Mastorakos and E.O. Long. LIG, NIAID, NIH. Albany Med. Col. (196.18) (187.9) 11:45 NKT cells induce IgG1 class switch against C. difficile carbohydrate antigens and enhance immunity 213. CELLULAR AND MOLECULAR MECHANISMS against a live pathogen challenge. M.L. Lang, OF VACCINES FOR ENHANCING PROTECTIVE G.A. Lang, S.A. Amani, B. Shrestha, T. Shadid, IMMUNE RESPONSES A.F. Gillaspy and J.D. Ballard. Univ. of Oklahoma Hlth. Sci. Ctr. (196.19) Block Symposium 12:00 Targeting antigen to lymph node lymphatic endothelial cells under steady-state to promote archiving and MON. 10:15 AM—ROOM 25ABC memory. C.D. Maulloo, D.S. Wilson, J.A. Hubbell CHAIRS: D.W. PASCUAL, V.H. KONJUFCA and M.A. Swartz. Univ. of Chicago. (196.20)

126 IMMUNOLOGY 2019™ SPEAKER DISCLOSURES

The American Association of Immunologists (AAI) does not offer CME credits for its annual meetings or programs held at its annual meetings. The AAI, however, requires that audiences at AAI-sponsored meetings or programs be informed of a presenter’s academic and professional affiliations, as well as any significant financial interests or other relationships a presenter may have with any research entity, proprietary or commercial entity producing pharmaceutical products or health care goods, or commercial entity producing products or services used in basic laboratory research.

The intent of disclosure is not to prevent a speaker from presenting or participating in a session, but rather to allow the audience to be fully knowledgeable of affiliations and relationships when evaluating the information being presented. Disclosure of support through federal grants is not required for these purposes.

If an unlabeled use of a commercial product or an investigational use not yet approved for any purpose is discussed during the presentation, the presenter must disclose that the product is not labeled for the use under discussion and/or that the product is still investigational.

Disclosure is required of any relationship that may bias a presentation or which, if known, would give the appearance of bias. These situations include, but are not limited to:

1. Stock, stock options, or bond holdings in a for-profit corporation directly held or indirectly held within a self-directed pension plan 2. Receipt of royalties from for-profit entities 3. Research grants, salary support, in-kind support from for-profit entities 4. Employment (full or part-time) in for-profit entities 5. Consulting fees or other remuneration from for-profit entities 6. Ownership or partnership in a research foundation or for-profit entity 7. Positions of influence such as officer, board member, trustee, or spokesperson for a research foundation, non-profitor for-profit entity 8. Paid speaker in a speakers bureau 9. Member of a Scientific Advisory Group for a foundation or for-profit entity 10. Other

The following presenters have submitted disclosures. The numbers following each name represent the specific relationships above. The number in parentheses represents the session number or abstract number. Disclosure is reprinted here as it was submitted by the presenter; if a presenter is not listed they have no relationships to disclose or did not submit a Speaker Disclosure Form. Invited and Guest Symposia Speakers

Ablasser, A., IFM Therapeutics, LLC – 1, 5, 7 (41) Hafler, D., Bristol-Myers Squibb; Compass Therapeutics; EMD Anderson, A., Aximmune; Compass Therapeutics; Potenza Serono; Genentech; JDRF; Novartis Pharmaceuticals; Therapeutics; Tizona Therapeutics; Zumutor – 5; 9; 9; 9; 9 Proclara Bioscience; Sanofi Genzyme; Versant Venture – 3; 5; (107) 5; 3, 9; 10; 5; 9; 5; 5 (16) August, A., 3M Corporation – 3 (31, 88) Harris, C., Admirx Inc.; GSK; Gyroscope Therapeutics; Iontas; Bhattacharya, D., Forty Seven, Inc.; Sana Biotechnology – 1; 1, 5 Rapharma; Roche – 5, 9; 5; 5; 3; 3; 9 (100) (142) Hartmann, G., Rigontec GmbH – 1, 5 (41) Butts, C., Biogen, Inc. – 4 (31, 49) Hildebrand, W., Pure MHC LLC; Pure Protein LLC; Cherry, S., Merck – 3 (199) Pure Transplant LLC – 1, 2, 5, 6, 7; 1, 2, 5, 6, 7; 1, 2, 5, 6, Collin, M., Genovis AB; Hansa Medical AB – 1, 5; 1, 2, 3, 5 (97, 7 (97, 153) 151, 161) Hornung, V., Inflazome – 9 (41) Conejo-Garcia, J., Anixa Biosciences; Compass Therapeutics – James, S., Merck Pharmaceuticals – 6 (30) 1, 3, 5, 6, 9; 1, 3, 5, 6, 9 (199) Kim, B., AbbVie; Concert; Incyte; Kiniksa; Locus Biosciences; Copper, M., Altor BioScience a NantWorks Company – 3 (160) Menlo; Nuogen Pharma; Pfizer; Regeneron; Sanofi; Crampton, S., Atyr Pharma – 1, 4 (49) Theravance – 5; 5; 5; 5; 1; 5; 6; 5; 5; 5; 5 (141) Crowe, J., Compuvax; GigaGen; IDBiologics; Meissa Vaccines; Locksley, R., Genentech – 9 (141) Moderma; Novavax; Pfizer; Sanofi; Takeda – 9; 9; 6; 9; 3; 5; 5; Maude, S., Kite Pharma; Novartis Pharmaceuticals – 5; 5 (107) 3, 5; 5 (199) Mohanakumar, T., NIH – 3 (33) Delgoffe, G., Bluebird Biok; Pfizer; Pieris Pharmaceuticals; Morel, L., Janssen – 5 (200) TCR2; TTMS, Inc.; Western Oncolytics – 3; 3; 5; 3; 2, 3; 5 (200) Nagler, C., ClostraBio, Inc. – 1, 3 (98) Farber, D., Bristol Myers Squibb – 3 (25) Pickl, W., Astra Zeneca; Biomay AG; EFIS; Novartis; Pfizer – 5; 1; Goldrath, A., Pandion – 1, 5 (142) 7; 5; 5 (151)

127 IMMUNOLOGY 2019™ SPEAKER DISCLOSURES

Powell, J., AbbVie; Bluebird; BMS; Corvus; Dracen: Roers, A., Celgene – 3 (41) Millipore-Sigma; Quadriga; Sityrx – 3; 3; 3; 1, 3, 5; 1, 3, 5; 5; 3, Rosenberg, S., Kite Pharma – 3 (174) 5; 1, 5 (200) Sauer, K., Torque Therapeutics – 1, 4 (49, 97) Quintana, F., AnTolRx. Inc.; Kyn Therapeutics; Synlogics – 1, 5, Smider, V., Indapta Therapeutics; NIH; Taurus Biosciences – 1, 6. 7; 9; 3 – (47, 201) 9; 3; 1, 7 (26) Rast, J., NovAb, Inc. – 1 (26) Snyder, M., NIM NIGMS R25 GM058264; R25 GM110070; HHMI Reed, E., Immucor – 3 (153) – 3; 3; 3 (30) Riddell, S., Juno – a Celgene company; Lyell Immunopharma – 1, Sokol, C., Adeo Health Sciences – 1, 9 (141) 3, 5; 1, 3, 5 (107) Turk, M., Celdara Medical, LLC – 1, 6 (17)

Authors

Acuff, N., BioLegend—4 (52.20, 64.15) Cali, J., Promega Corporation—4 (52.19) Adams, J., Arena Pharmaceuticals—4 (119.31) Camblin, A., Merrimack Pharmaceuticals—4 (195.11) Adase, C., Multimeric Biotherapeutics, Inc.—4 (196.6) Campbell, J., ChemoCentryx, Inc—1, 4 (133.7) Agorku, D., Miltenyi Biotec—4 (134.15, 194.26) Campesato, L.F., Merck—5 (137.3) Ahearn, J., Exagen Diagnostics—2 (182.8) Cao, Y., Genentech Inc.—4 (132.4) Ahmad, G., Torque Therapeutics—4 (71.10) Carambula, R., CEL-SCI Corporation—1 (133.4) Allen, I., Angiodynamics—3 (194.31) Carr, D., Rational Vaccines Inc.—5, 9 (75.19) Alm, K., Phase Holographic Imaging—4 (131.14) Caruso, S., Torque Therapeutics—4 (136.20) Alvarez, C., Boehringer Ingelheim—3 (190.71) Chan, L., Nexcelom Bioscience—4 (130.8) An, W., BioLegend, Inc.—4 (184.6) Chan, S., Genentech Inc.—4 (132.4) Anderson, A., Compass Therapeutics; Potenza Therapeutics; Chan, T., An2H; AstraZeneca; Bristol-Myers Squibb; Eisai; Tizona Therapeutics; Zumutor Biologics—9; 9; 9; 9 (137.15) Gritstone Oncology; Illumina; Personal Genome Diagnostics; Andresen, T., Torque Therapeutics—4; 4 (71.10, 136.20) Pfizer—3; 3; 3; 3; 6; 3; 2; 3 (137.11) Antonchuk, J., STEMCELL Technologies Inc.—4 (71.3) Chanan-Khan, A., Affimed Therapeutics, AG—3 (71.12) Ashworth, A., AstraZeneca—3 (130.6) Chang, D-K., Torque Therapeutics—4 (71.10) Austin, C., Genentech Inc.—4 (132.4) Charo, I., ChemoCentryx, Inc—4 (133.7) Bagwell, C., Fluidigm—5 (131.2) Chen, P., STEMCELL Technologies Inc.—4 (71.3) Bailey, C., NanoString Technologies—4 (131.26) Chhina, V., ChemoCentryx, Inc—4 (133.7) Bailey, M., NanoString Technologies—4 (131.26) Chi, E., Janssen Pharmaceutical Companies of Johnson & Bansal, N., BD Biosciences—4 (131.35) Johnson—4 (57.9) Bansal-Pakala, P., Janssen Pharmaceutical Companies of Chiba, K., Mitsubishi Tanabe Pharma Corporation—4 (132.1) Johnson & Johnson—4 (57.9) Cho, B., Protein Fluidics—4 (51.20) Bao, J., Akadeum Life Sciences—4 (131.1) Chow, K., BioLegend—4 (130.24, 130.25) Baracho, G., BD Biosciences—4 (131.35) Christopher, R., Arena Pharmaceuticals—10 (119.31) Baranov, V., Fluidigm—1, 4 (131.2) Chronopoulou, E., BioLegend, Inc.—4 (184.6) Baranska, A., Miltenyi Biotec—4 (194.26) Chu, S., Molecular Templates—4 (70.21) Bardwell, P., Torque Therapeutics—4 (136.20) Ciemielewski, J., CEL-SCI Corporation—1 (133.4) Barrio, A., 10x Genomics—4 (131.13, 131.4, 194.29) Cobb, B., Boehringer Ingelheim—3 (190.71) Barski, A., Datirium, LLC—6 (125.13) Cooper, L., CellChorus; Ziopharm Oncology—6; 4, 6 (134.2) Barsoumian, H., RadScopal Trademark—6 (136.11) Cornelison, G., Molecular Templates—4 (70.21) Bhandari, R., Celdara Medical LLC—3 (182.37) Cortez, M.A., RadScopal Trademark—6 (136.11) Blanchette, C., Genentech Inc.—4 (132.4) Covey, T., Acerta Pharma B.V.—4 (136.19) Bonissone, S., Digital Proteomics—4 (123.16, 131.23) Cox, B., CoPharm Global Consulting; TriSalus Life Sciences, Boutet, S., 10x Genomics; OneTraction Inc; Fluidigm—4; 7; 10 Inc.—5; 5 (71.1, 130.1) (131.4, 194.29) Crawford, J., Genentech—4 (133.3) Bradford, J., Thermo Fisher Scientific—4 (131.41) Criado-Moronati, E., Miltenyi Biotec—4 (194.26) Brauner, J., Miltenyi Biotec—4 (134.15) Cromwell, E., Protein Fluidics—6 (51.20) Brehm, M., The Jackson Laboratory—3, 5 (126.37) Crosby, C., Arena Pharmaceuticals—4 (119.31) Brieschke, B., Molecular Templates—4 (70.21) Daftarian, P., JSR Life Sciences; MBL International—4; 4 (195.35) Bristol, N., Protein Fluidics—4 (51.20) Dai, B., Genentech inc.—4 (132.4) Brix, L., Immudex—4, 7 (131.13, 131.4) Dang, T., ChemoCentryx, Inc—4 (133.7) Brown, B., iRepertoire—4 (131.24, 131.25, 131.28, 131.6) Darou, S., BioSpherix—4 (131.14) Browning, J., F. Hoffmann-La Roche Ltd; Lupus Research Darwish, M., Genentech Inc.—4 (132.4) Alliance—3; 5 (182.49) Davalos, R., Angiodynamics—3 (194.31) Budhu, S., Agenus—2 (136.23, 137.3) Davidson, B., Luminex Corporation—4 (131.5) Byrne-Steele, M., iRepertoire Inc.—4; 4 (131.6, 131.24, 131.25, Dekker, J., Molecular Templates—4 (70.21) 131.28) Deng, L., Imvaq therapeutics—3, 6, 9 (197.8) Calderon, V., Thermo Fisher Scientific—4 (130.16) Depinet, M., iRepertoire—4 (131.24, 131.25, 131.28)

128 IMMUNOLOGY 2019™ SPEAKER DISCLOSURES

Dervieux, T., Exagen Diagnostics—4, 7 (182.8) He, D., Genentech Inc.—4 (132.4) DiAntonio, A., Disarm Therapeutics—9 (64.1) Heath, W., Avalia Immunotherapies—9 (196.27) Divekar, A., BioLegend—4 (52.20, 64.15) Heemskerk, B., Miltenyi Biotec—4 (194.26) Dose, C., Miltenyi Biotec—4 (130.31, 134.15, 194.26) Heller, R., OncoSec Medical, Inc—1, 9 (136.2) Druker, B., Aileron Therapeutics, Vivid Biosciences; Aptose, Henn, A., BioSpherix—4 (131.14) Blueprint, Third Coast Therapeutics, GRAIL, Beta Cat; Henn, S., BioSpherix—4 (131.14) Burroughs Wellcome Fund; Cepheid; Gilead; Monojul; Herath, K.H.I.N.M., Ministry of Oceans and Fisheries (Project Novartis, Bristol-Meyers Squibb, Pfizer; OHSU, Dana Farber NO. 20172085); Ministry of Oceans and Fisheries, Korea—3; Cancer Institute—9; 1; 7; 9; 9; 5; 3; 2 (195.10) 3; 3 (117.22, 119.10, 187.30, 187.31) Drummond, D., Merrimack Pharmaceuticals—4 (195.11) Hewes, B., Torque Therapeutics—4 (136.20) Dutta, B., AstraZeneca—4 (59.6) Hildebrand, W., Pure MHC—7 (195.12) Eastham-Anderson, J., Genentech Inc.—4 (132.4) Holz, L., Avalia Immunotherapies—3 (196.27) Eaves, A., STEMCELL Technologies Inc.—6; 6 (71.3, 130.14) Hou, X., iRepertoire—4 (131.24, 131.25, 131.28) Ebsworth, K., ChemoCentryx, Inc—4 (133.7) Humeau, L., Inovio Pharmaceuticals—4 (70.4) Edgcomb, S., BPS Bioscience—4 (71.19) Hunsberger, B., Fluidigm—5 (131.2) Eidenschenk, C., Genentech—4 (133.3) Hwang, S-A., Myriad RBM—4 (130.22, 131.26) Eisenhower, M., iRepertoire—4 (131.25, 131.28) Iberg, A., Molecular Templates—4 (70.21) Eisinger, D., Myriad RBM—4 (130.22) Inoue, M., AYUMI Pharmaceutical Corporation; Chugai Elia, J., BioLegend, Inc.—4 (184.6) Pharmaceutical Co.; Noevir Co.—3; 3; 3 (189.3) Elliott, N., Nanostring Technologies—4 (131.26) Jachimowicz, L., ACEA Biosciences—4 (130.17) Ertl, L., ChemoCentryx, Inc—4 (133.7) Jacobsen, K., Immudex—4 (131.13, 131.4) Espat, N.J., IV Diagnostics, Inc.—9; 9 (71.1, 130.1) Jaroch, D., TriSalus Life Sciences, Inc.—1, 4 (71.1, 130.1) Essuman, K., Disarm therapeutics-Washington University—2 Jee, Y., Ministry of Oceans and Fisheries, Korea—3 (187.30, (64.1) 187.31) Evaristo, C., Miltenyi Biotec—4 (130.31, 134.15, 194.26) Jeon, Y-J., Ministry of Oceans and Fisheries (Project NO. Everett, C., Genentech—4 (133.3) 20172085); Ministry of Oceans and Fisheries, Korea—3; 3; 3; 3 Ewen, C., STEMCELL Technologies—4 (130.14) (117.22, 119.10, 187.30, 187.31) Fitzgerald, J., Torque Therapeutics—4 (136.20) Jhaveri, A., AnTolRx—1, 4 (193.13) Flynn, J., Bill and Melinda Gates Foundation; NIH—3; 3 (139.3) Ji, S., BioLegend—4 (130.24, 130.25) Foerster-Marniok, A., Miltenyi Biotec—4 (130.31) Jiang, W., BioLegend—4 (130.24, 130.25) Frank, A., BioSpherix—4 (131.14) Jiao, Y., Merrimack Pharmaceuticals—4 (195.11) Franke, Y., Genentech Inc.—4 (132.4) Johnson, A., Genentech—4 (133.3) Freeman, G., AstraZeneca; Boehringer-Ingelheim; Bristol Myers Johnson, J., Cayman Chemical Company—6 (137.11) Squibb; EMD Serono; Merck; Novartis Roche—10; 10; 10; 10; Jones, B., Janssen R&D—4 (57.9) 10; 10; 10 (195.31) Jones, D., [email protected]—4 (71.10) Frey, A., BioLegend, Inc.—4 (184.6) Jovanovic, V., STEMCELL Technologies—4 (130.14) Fulton, R., Merrimack Pharmaceuticals—4 (195.11) Katz, S., TriSalus LifeSciences, Inc.; TNK Therapeutics, Inc.—3, Gaudet, J., Magnetic Insight—1, 4 (130.7) 9; 3, 9; 3, 9; 3 (71.1, 130.1) Georgiou, G., Aeglea Biotherapeutics Inc—1 (137.11) Kenison-White, J., AnTolRx—1 (193.13) Geretti, E., Torque Therapeutics—4 (136.20) Kennedy, P., Cayman Chemical Company—4 (137.11) Gerhart, R., Thermo Fisher Scientific—4 (126.38) Kim, A., Ministry of Oceans and Fisheries (Project NO. Gert, P., Miltenyi Biotec—4 (194.26) 20172085); Ministry of Oceans and Fisheries, Korea—3; 3; 3 Ghilardi, N., Genentech—4 (133.3) (117.22, 119.10, 187.30, 187.31) Giangarra, V., 10x Genomics—4 (194.29) Kim, H.J., Ministry of Oceans and Fisheries (Project NO. Gijon,´ M., Cayman Chemical Company—4 (137.11) 20172085); Ministry of Oceans and Fisheries, Korea—3; 3; 3 Glimcher, L., Abro and Kaleido Therapeutics; GlaxoSmithKline (117.22, 119.10, 187.30, 187.31) Pharmaceuticals; Quentis Therapeutics; Repare Therapeutics; Knight, R., Sorrento Therapeutics, Inc.—4 (130.1) the Waters Corporation—9; 9; 6; 9; 9 (63.15) Ko, M-O., Ministry of Oceans and Fisheries (Project NO. Godfrey, D., Avalia Immunotherapies—9 (196.27) 20172085); Ministry of Oceans and Fisheries, Korea—3; 3; 3; 3 Goodwill, P., Magnetic Insight—1 (130.7) (117.22, 119.10, 187.30, 187.31) Grabow, S., Merrimack Pharmaceuticals—4 (195.11) Kokaji, A., STEMCELL Technologies Inc.—4; 4 (71.3, 130.14) Greenfield, E., Novartis—10 (195.31) Komori, H., Arena Pharmaceuticals—4 (119.31) Greiner, D., The Jackson Laboratory—3, 5 (126.37) Kornbluth, R., Multimeric Biotherapeutics, Inc.—4, 6 (196.6) Guenther, G., ACEA Biosciences—4 (130.17) Koshkaryev, A., Merrimack Pharmaceuticals—4 (195.11) Guerau-De-Arellano, M., Prelude Therapeutics—2 (119.6) Krogsgaard, M., AgenTus; Agenus; Merck; XCella Biosciences Haller, S., Genentech Inc.—4 (132.4) Inc.—3; 3; 3; 5 (194.5) Hamilton, V., Multimeric Biotherapeutics, Inc.—4 (196.6) KU, C-L., Elixiron Biotech—9 (182.77) Han, J., iRepertoire Inc.—6; 6 (131.6, 131.24, 131.25, 131.28) Kuchroo, V., Celsius Therapeutics; Potenza Therapeutics; Hardt, O., Miltenyi Biotec—4 (134.15, 194.26) Tizona Therapeutics—6; 9; 9 (137.15) Hartmann, G., Rigontec GmbH—10 (198.12) Kumamoto, A., ChemoCentryx, Inc—4 (133.7) Hayer, E., STEMCELL Technologies—4 (130.14) Kumar, S., Merrimack Pharmaceuticals—4 (195.11)

129 IMMUNOLOGY 2019™ SPEAKER DISCLOSURES

Kurella, V., Merrimack Pharmaceuticals—4 (195.11) Meskas, J., Cytapex Bioinformatics, Inc—4 (131.41) Kwieraga, A., BioLegend, Inc.—4 (184.6) Mihindukulasooriya, S.P., Ministry of Oceans and Fisheries, LaBrie, S., Myriad RBM—4 (130.22, 131.26) Korea—3; 3 (117.22, 119.10, 187.30, 187.31) Laddy, D., AERAS—4 (139.3) Mikecz, K., CEL-SCI Corporation—1 (133.4) Laing, S., Genentech—4 (133.3) Mikkelsen, T., 10x Genomics—4 (131.13, 131.4, 194.29) Lambert, J., Quanterix—4 (52.21, 131.11) Milbrandt, J., Chromadex; Disarm Therapeutics (SAB)—10; 9 Lau, J., 10x Genomics—4 (131.4, 194.29) (64.1) Lazar, D., Promega Corporation—4 (52.19) Montesclaros, L., 10x Genomics—4; 1 (131.4, 194.29) Lazarus, R., Genentech Inc.—4 (132.4) Montoya, L., Thermo Fisher Scientific—4 (130.16) Leber, A., Landos Biopharma—4 (132.7) Morrissey, P., Luminex Corporation—4 (131.5) Lee, J., 10x Genomics—4 (131.13, 131.4, 194.29) Mortimer, S., BD Biosciences—4 (131.35) Lee, W., Genentech Inc.—4; 4 (132.4, 133.3) Mouchess, M., Genentech—4 (132.4) Lehmann, J., BioLegend—4 (130.24, 130.25) Muda, M., Merrimack Pharmaceuticals—4 (195.11) LeMar, S., Molecular Templates—4 (70.21) Nakamoto, M., Becton Dickinson—4 (189.18) Li, J., Boehringer Ingelheim—4 (185.16) Narayanan, B., Pfizer—4 (186.16) Li, M., BioLegend, Inc.—4 (184.6) Nardozzi, J., Torque Therapeutics—4 (71.10) Li, N., ACEA Biosciences—4 (130.17) Navert, R., Thermo Fisher Scientific—4 (126.38) Li, S., iRepretoire Inc.—4 (131.24) Newland, D., ChemoCentryx, Inc—4 (133.7) Li, S., Fluidigm—1, 4 (131.2) Nielsen, M., Sir Sciences—7 (195.12) Liang, X., Torque Therapeutics—4 (136.20) Nizet, V., Cellular Approaches—9 (196.28) Liby, K., Reata Pharmaceuticals—3 (135.17) Nowakowska, D., AnTolRx—1, 4 (193.13) Lind, E., Amgen; Celgene; Fluidigm; Janssen; Monojul—3; 3; 8; O’Brien, M., Promega Corporation—4 (52.19) 3; 3 (195.10) O’Connor, R., Nucleus Biologics—3 (131.22) Liu, C., Janssen Pharmaceutical Companies of Johnson & O’Grady, M., Thermo Fisher Scientific—4 (130.16) Johnson—4 (57.9) Oida, T., BioLegend—4 (64.15) Liu, H., iCubate—4 (131.24) Okamoto, K., AYUMI Pharmaceutical Corporation; Chugai Liu, S., ChemoCentryx, Inc—4 (133.7) Pharmaceutical Co.; Noevir Co.—3; 3; 3 (189.3) Loewendorf, A., ImmunoVation—6 (182.64) Olsen, C., Protein Fluidics—4 (51.20) Lomas, W., BD Biosciences—4 (131.35) Ornatsky, O., Fluidigm—1, 4 (131.2) Low, Q., Thermo Fisher Scientific—4 (130.16) Ostruszka, L., Akadeum Life Sciences—4 (131.1) Lu, Y., ACEA Bio—4 (130.17) Ouerkaxi, W., MBL International—4 (195.35) Lulo, J., Merrimack Pharmaceuticals—4 (195.11) Pamer, E., Bristol Myers Squibb; Celgene; Ferring Luus, L., Merrimack Pharmaceuticals—4 (195.11) Pharmaceuticals; MedImmune; Novartis; Seres Therapeutics; Lyons, J., Torque Therapeutics—4; 4 (71.10, 136.20) Seres Therapeutics—10; 10; 10; 10; 10; 10; 2 (66.8) Majonis, D., Fluidigm—1, 4 (131.2) Pan, W., iRepertoire—4 (131.24, 131.25, 131.28) Mali, V., ChemoCentryx, Inc—4 (133.7) Paragas, V., Merrimack Pharmaceuticals—4 (195.11) Malo, K., Inovio Pharmaceuticals—4 (70.4) Park, K., BioLegend, Inc.—4 (184.6) Manfredi, M., KYN Therapeutics—4 (137.3) Patel, A., Digital Proteomics—4 (123.16) Mansfield, J., Magnetic Insight—1 (130.7) Petlakh Co, N., Akadeum Life Sciences—4 (131.1) Manuchehrabadi, N., Angiodynamics—4 (194.31) Pfeiffer, K., 10x Genomics—4 (131.13, 131.4, 194.29) Mao, X., Disarm Therapeutics—2 (64.1) Pietz, N., Miltenyi Biotec—4 (130.31) Marrs, S., 10x Genomics—4 (194.29) Pioli, P., Celdara Medical LLC—3 (182.37) Marsh, H., Celldex Therapeut.—4 (136.4) Pitzka, C., Miltenyi Biotec—4 (130.31) Marson, A., Epinomics; Gilead; Juno; Juno Therapeutics; PACT Posarac, V., STEMCELL Technologies—4 (130.14) Pharma; Sanofi; Spotlight Therapeutics—3; 3; 5; 3; 9; 3; 6 Presa, M., JDRF Fellowship 3-PDF-2014-219-A-N (completed)— (130.6) 3 (115.8) Martinez Becerra, F., Nucleus Biologics—4 (131.22) Pugsley, H., Luminex Corporation—4 (131.5) Masteller, E., Inovio Pharmaceuticals—4 (70.4) Putterman, C., Exagen Diagnostics—3 (182.8) Master, A., Nucleus Biologics—4 (131.22) Qiu, J., Merrimack Pharmaceuticals—4 (195.11) McGovern, K., Kyn Therapeutics—4 (137.3) Quintana, F., AnTolRx—7 (193.13) McMahon, J., ChemoCentryx, Inc—4 (133.7) Racine, J., Diabetes Research Connection; JDRF; JDRF Merghoub, T., Adaptive Biotechnologies; Agenus; Alpha Virus Fellowship 3-PDF-2017-372-A-N; NIH-NIDDK—3; 3; 3; 3 Based Vaccine; Aprea; Bristol Myers Squibb; CD40; (115.5, 115.15, 115.8) Combination therapy of CD40, GITR, OX40, PD-1 and Rajan, S., Genentech—4 (131.19) CTLA-4; CTLA-4; GITR; Immunos Therapeutics; IMVAQ Ramos, H., Molecular Templates—4 (70.21) therapeutics; Infinity Pharmaceuticals, Inc.; Kyn Therapeutics; Raue, A., Merrimack Pharmaceuticals—4 (195.11) Leap Therapeutics, Inc.; Neo Antigen Modeling; Oncolytic Viral Razlog, M., Merrimack Pharmaceuticals—4 (195.11) therapy; OX40; PD-1; Peregrine Pharmeceuticals, Inc.; Pfizer; Regev, A., Celsius Therapeutics; Syros Pharmaceuticals; Surface Oncology—3, 3, 3; 2; 2; 10; 3, 3, 3; 3, 3, 3; 10; 2; 10; 10; Thermo Fisher—6; 9; 9 (137.15) 5, 5, 5; 6; 10, 10; 3, 3, 3; 3, 3, 3; 3, 3, 3; 2; 10; 2; 10; 10; 10; 3, 3, Rene, O., Novartis—4 (133.3) 3; 5, 5, 5; 3, 3 (134.13, 136.23, 137.3) Reyes, A., BioLegend, Inc.—4 (184.6)

130 IMMUNOLOGY 2019™ SPEAKER DISCLOSURES

Richards, J., Merrimack Pharmaceuticals—4 (195.11) Swain, P., Agilent Technologies—4 (56.16) Richter, A., Miltenyi Biotec—4 (130.31, 134.15, 194.26) Swiecki, M., Janssen Pharmaceutical Companies of Johnson & Riordan, D., 10x Genomics—4 (131.4) Johnson—4 (57.9) Robek, M., Carogen Corporation—1 (196.18) Symons, A., Amgen—4 (68.7) Robinson, G., Molecular Templates—4 (70.21) Tacke, R., Cellular Approaches—4 (196.28) Roidan, D., 10x Genomics—4 (131.13) Tajti, G., Miltenyi Biotec Ltd.—10 (131.9) Rooney, C., Cell Genix; Marker; Tessa Therapeutics; Takeuchi, T., Mitsubishi Tanabe Pharma Corporation—3 (132.1) Viracyte—9; 10; 10; 10 (71.9) Tam, C., Genentech Inc.—4 (132.4) Rosenthal, K., CEL SCI—10 (133.4) Tam, E., Merrimack Pharmaceuticals—4 (195.11) Roussey, J., Akadeum Life Sciences—4 (131.1) Taylor, I., BD Biosciences; Becton Dickinson—4; 4 (131.35, Rughwani, P., BioLegend—4 (130.24) 189.18) Rutz, S., Roche; Genentech—1; 4 (57.19, 133.3) Taylor, S., 10x Genomics—4 (131.13, 131.4, 194.29) Sa, S., BD Biosciences—4 (131.35) Tchaicha, J., KYN Therapeutics—4 (137.3) Sabri, N., BioLegend, Inc.—4 (184.6) Tezza, S., AnTolRx—1, 4 (193.13) Sackton, K., Torque Therapeutics—4 (71.10) Thomas, T., STEMCELL Technologies Inc.—4; 4 (71.3, 130.14) Saksena, S., Becton Dickinson—4 (189.18) Thorne, A., Inovio Pharmaceuticals—4 (70.4) Sampson, J., Merimack Pharmaceuticals—4 (195.11) Truong, D., STEMCELL Technologies Inc.—4 (71.3) Santamaria, P., Parvus Therapeutics Inc.—3, 7 (132.17) Tyner, J., Aptose, Array, AstraZeneca, Constellation, Genentech, Sapida, J., 10x Genomics—4 (131.13, 194.29) Gilead, Incyte, Janssen, Seattle Genetics, Syros, Takeda; Sardina, P., Thermo Fisher Scientific—4 (131.41) Vivid Biosciences—3; 6 (195.10) Sasaki, Y., Chromadex; Disarm Therapeutics—10; 2 (64.1) Varadarajan, N., CellChorus—6 (134.2) Sauer, K., Torque Therapeutics—4 (71.10, 136.20) Vaughan, B., 4Life—4 (183.18) Savas-Carstens, J., BioLegend, Inc.—4 (184.6) Vieira-Brock, P., 4Life—4 (183.18) Schall, T., ChemoCentryx, Inc—4 (133.7) Virgin, H., Casma Therapeutics—6 (177.23) Schrantz, N., Thermo Fisher Scientific—1, 4 (126.38) Vorholt, D., Miltenyi Biotec—4 (194.26) Seki, N., Mitsubishi Tanabe Pharma Corporation—4 (132.1) Wagner, D., Op-T, LLC; Op-T-Mune Inc—6; 6; 7 (182.45, 115.4, Selvaraj, P., Metaclipse Therapeutics—6 (70.7) 68.9) Serreze, D., JDRF; NIH grants DK-46266, DK-95735, and Wagner, U., Celltics GmbH—6 (182.51) OD-020351-5022; NIH-NIDDK; NIH-Office of the Director—3; Waid, D., Kyn Therapeutics—4 (68.9) 3; 3; 3; 3 (115.15, 115.5, 115.8) Walter, D., 10x Genomics—4 (131.13, 131.4) Shao, Z., Amgen Inc—4 (68.7) Wang, Y., ChemoCentryx, Inc—4 (133.7) Sharpe, A., AstraZeneca; Boehringer-Ingelheim; Bristol-Myers- Ware, C.F., Boehringer-Ingelheim—3 (185.16) Squibb; EMD-Serono; Merck, EMD-Serono, Boehringer- Warren, S., Nanostring Technologies—4 (131.26) Ingelheim, AstraZeneca, and Novartis. G; Novartis.; Watson, A., STEMCELL Technologies Inc.—4 (71.3) Roche—10; 10; 10; 10; 10; 10; 10 (195.31) Webb, T., Immunaccel, LLC; WebbCures, LLC—5; 6 (194.45) Shirwan, H., FasCure Therapeutics, LLC—6, 7 (71.6) Weber, M., iRepertoire—4 (131.28) Shollenberger, L., Studylog Systems—10 (131.10) Weinstein, A., Exagen—1, 7 (182.8) Shuman, S., Imvaq therapeutics—6, 9 (197.8) Welsh, J., Checkmate Pharmaceuticals; Mavupharma; Molecular Siemer, R., Miltenyi Biotec—4 (134.15, 194.26) Match; OncoResponse; RadScopal Trademark; RefleXion Singh, A., Miltenyi Biotec—4 (194.26) Medical—9; 9; 6; 6; 6; 9 (136.11) Singh, R., ChemoCentryx, Inc—4 (133.7) Widmann, S., BD Biosciences—4 (131.35) Sirenko, O., Molecular Devices, LLC—4 (51.20) Willert, E., Molecular Templates—4 (70.21) Smith, P., AstraZeneca Ltd—4 (134.13) Wolchok, J., Adaptive Biotech; Adaptive Biotechnologies; Song, H-W., BD Biosciences—4 (131.35) Advaxis; Amgen; Apricity; Array BioPharma; Ascentage Soper, D., BioLegend, Inc.—4 (184.6) Pharma; Astellas; Bayer; Beigene; BMS; Bristol Myers Squibb; Spiess, C., Genentech—4 (131.19) Celgene; Chugai; Eli Lilly; Elucida; F Star; Genentech; Imvaq; Srivastava, P., Truvax—6 (58.15) Janssen; Kleo Pharma; Linneaus; MedImmune; Merck; Merck Stadler, P., Quanterix—4 (52.21) Pharmaceuticals; Neon Therapeutics; Ono; Polaris Pharma; Stepniak, D., Thermo Fisher Scientific—1, 4 (126.38) Polynoma; Potenza Therapeutics; Psioxus; Puretech; Stone, E., Aeglea Biotherapeutics Inc—1 (137.11) Recepta; Sellas Life Sciences; Serametrix; Surface Oncology; Strake, B., Janssen Pharmaceutical Companies of Johnson & Syndax; Tizona Pharmaceuticals; Trieza; Xenogeneic DNA Johnson—4 (57.9) Vaccines—5; 1,10; 5; 5; 5; 5; 5; 5; 5; 1, 5, 10; 5; 3, 5; 5; 5; 1, 5, Stubbington, M., 10x Genomics—4 (131.13, 131.4, 194.29) 10; 5; 3, 5; 1, 5, 10; 5; 1, 5, 10; 3, 5; 5; 3; 5; 5; 5; 5; 1, 10; 5; 5; 5; Studer, S., Multimeric Biotherapeutics, Inc.—4 (196.6) 5; 5; 5; 5; 1, 10; 1, 5, 10; 2, 10 (134.13, 36.23, 137.3) Suchy, J., Merrimack Pharmaceuticals—4 (195.11) Wong, A., Inovio Pharmaceuticals—4 (70.4) Sugahara, K., Mitsubishi Tanabe Pharma Corporation—4 (132.1) Sukovich, D., 10x Genomics—4 (131.13) Sun, B., BioLegend—4 (130.24, 130.25) Suto, E., Genentech Inc.—4 (132.4)

131 IMMUNOLOGY 2019™ SPEAKER DISCLOSURES

Wong, C., Merrimack Pharmaceuticals—4 (195.11) Youngheun, J., Ministry of Oceans and Fisheries—3 (117.22, Wong, K-K., Array; AstraZeneca; BMS; Janssen; Merck; 119.10) Novartis; Ono; Pfizer; Takeda; TargImmune—5; 5; 3; 5; 5; 5; 5; Yu, J., STEMCELL Technologies Inc.—4 (71.3) 5; 5; 5 (134.13) Yussman, M., Op-T-Mune Inc—7 (68.9) Woodside, S., STEMCELL Technologies Inc.—4; 4 (71.3, Zahner, S., Thermo Fisher Scientific—4 (126.38) 130.14) Zamarin, D., ACM Biolabs; Biomed Valley Discoveries; Merck; Wu, K., 10x Genomics—4 (194.29) Psioxus Therapeutics; Synlogic Therapeutics; Tesaro; Tizona Xi, L., Merrimack Pharmaceuticals—4 (195.11) Therapeutics—5; 5; 3, 5; 5; 5; 9; 5 (137.3) Yang, N., Imvaq therapeutics—3 (197.8) Zbieg, J., Genentech—4 (133.3) Yang, X., BioLegend, Inc.—4; 4 (52.2, 64.15, 184.6) Zeldis, J., Sorrento Therapeutics, Inc.—1, 4 (130.1) Yau, S., ChemoCentryx, Inc—4 (133.7) Zhang, J., Genentech—4 (133.3) Ye, P., ACEA Bio—4 (130.17) Zhang, P., ChemoCentryx, Inc—4 (133.7) Yee, C., Adaptive Biotechnologies; Parker Institute for Cancer Zhao, A., BioLegend—4 (130.24, 130.25) Immunotherapy; Stand Up to Cancer—9; 3; 3 (189.10) Zhao, X., BioLegend—4 (131.13, 131.4) Yellin, M., Celldex Therapeut—4 (136.4) Zheng, G., 10x Genomics—4 (194.29) Yerden, R., BioSpherix—4 (131.14) Zhu, H., BPS Bioscience—6 (71.19) Yeung, B., BioLegend—4 (131.13, 131.4) Zimmerman, D., CEL SCI Corporation—1, 4, 7 (133.4) Yi, T., Genentech Inc.—4 (132.4) Ziraldo, S., 10x Genomics—4 (194.29) Yolcu, E.S., FasCure Theraputics, LLC—3, 7 (71.6) Zou, W., EMD Serono; Henlix; Lycera; NGM; Synlogic—5; 5; 5; 5; Younger, J., AERAS—4 (131.1) 5 (137.11)

132 AUTHOR/SPEAKER INDEX

The number following each name refers to the abstract number. Numbers following an S refer to the invited speaker session number.

A Ackerman, Margaret, Aguilera-Aguirre, Albakri, Marwah, 136.7 Allen, Irving, 67.7, 128.8, 72.6, 72.9 Leopoldo, 127.13 Albareda, Maria, 190.60 129.11, 182.30, Abba, Martin, 123.19 Acosta, Ometeotl, Ahearn, Joseph, 182.8 Alberola-Ila, Jose, 65.7 194.30, 194.31 Abbasi, Nazia, 125.20 182.78 Ahlmanner, Filip, 138.13 Albin, Tyler, 131.32 Allen, Kaity, 74.12 Abbott, D. Wade, Acres, Megan, 52.14 Ahmad, Ali, 75.14 Albina, Jorge, 62.10 Allen, Marilyn, 132.15 192.19 Acuff, Nicole, 52.20, Ahmad, Faria, 64.23 Albrecht, Randy, 127.18 Allen, Steven, 182.62 Abbott, Derek, 51.21 64.15 Ahmad, Gulzar, 71.10 Alcorn, John, 66.11, Allers, Carolina, 190.79 Abbott, Jeffrey, 196.2 Adams, Robert, 198.8 Ahmad, Javeed, 120.7 190.49, 198.10 Alli, Abdel, 192.13 Abboud, Georges, Adams, Erin J., S78 Ahmad, Nafees, 140.22 Aldridge, Brian, 73.21 Allison, James, 69.10 66.19, 132.12 Adams, John, 119.31 Ahmad, Rasheed, Alegre, Maria-Luisa, Allman, David, 188.3 Abdelhamid, Leila, Adams, Nicholas, 181.18 69.12 Alloy, Annie, 66.2 178.10 63.15, 76.3 Ahmed, Rafi, 56.6 Allushi, Bujana, 178.15 Abdelsamed, Hossam, Alehashemi, Sara, 63.4 Adase, Christopher, Ahmed, S Ansar, 50.4, Alm, Kersti, 131.14 134.14 Alekseev, Andrei, 196.6 50.13 Abdul Qayum, Amina, 124.12, 138.18 Almaghrabi, Fatimah, Ahmed, Yamine, 135.5 185.5 Addorisio, Meghan, Alexander, Amanda, 191.5 133.17 Abdul-Baki, Nawal, Ahmer, Brain, 55.4 180.7 Al-Mansouri, Alreem, 123.4 Adebayo, Olayinka, Ahn, Gi Beom, 134.20 Alexander, Roberta, 66.9 Abe, Brian, 120.33 52.7, 52.8, 181.17, Ahn, Ji Hae, 70.12 182.8 Almasoud, Abe, Yohei, 187.21 194.36 Aiden, Aviva, 123.18 Alexander, Stephen, Abdulrahman, 139.10 Abernathy Close, Lisa, Adeegbe, Dennis, Aihara, Fumiaki, 198.14 74.10 Almeida, Caroline, 190.69 194.42 Ailawadhi, Sikander, Alexander-George, 128.19 Ablasser, Andrea, S41 Ademola, Ayankunle, 71.12, 71.13 Lou-Ella, 188.15 Almeida, Roque, 52.23, Aboelatta, Mones, 120.29 Akahoshi, Doug, 127.10 Alexander-Miller, 190.22 136.6 Aderem, Alan, 75.11 Akanni, Olufemi, 120.29 Martha, 74.13 Almer, Sven, 65.6, Abou-Slaybi, Abdo, Adimora, Adaora, Akbari, Omid, 51.12, Alexandre, Jason, 187.10 117.15 197.14 122.10 194.21 Almo, Steven, 131.8, Abraham, Susamma, Adler, Fred, 180.7 Akbay, Esra, 134.13 Aleynick, Mark, 70.9 182.56 58.4, 127.7 Admasu, Wasihun, Akeus, Paulina, 138.14 Algaissi, Abdullah, Al-Mousa, Hamoud, Abrahante, Juan, 198.4 190.56 Akgul, Ali, 196.2 139.10 52.14 Abramova, Anastasia, Adolacion, Jay R, Akhade, Ajay, 59.6, Alghetaa, Hasan, 67.10 Alonzo, Francis, 190.47 177.5 134.2, 134.6 63.13 Algood, Holly, 117.20 Alqassim, Emad, 137.13 ` Abrams, Scott, 195.26 Adori, Monika, 72.9 Akhter, Anwari, 62.20 Alharbi, Naif, 139.10 Alrafas, Haider, 135.18, Abreu, Rodrigo, 139.19, Adusei, Matthew, 135.9 Aki, Daisuke, 188.14 Al-Harthi, Lena, 117.10 191.10, 192.12 139.23 Afzali, Behdad, 125.5 Akkaya, Billur, 57.17, Alhomsy, Yasmeen, Al-Ramadi, Basel, 50.16 Abrishami, Simin, 118.6 Agarwal, Ruchira, 121.5, 124.8, 128.6 194.12 al-Ramadi, Basel, 66.9 Abt, Michael, 66.8 116.15 Akkaya, Munir, 121.2, Ali, Ayad, 76.7 Alrashed, Fatema, Abuirqeba, Suomia, Agasing, Agnieshka, 130.2, 190.7 Ali, Mohamed, 190.20 181.18 137.7 68.12 Al Abosy, Rose, 58.17 Ali, Shamsideen, 61.6 Al-Sbiei, Achraf, 66.9 Abulkhir, Ayoub, 75.14 Agazio, Amanda, 179.14 Al Hashash, Jana, Ali, Shihabudeen, Alshetaiwi, Hamad, Acevedo-Ochoa, Agemy, Lilach, 135.23 135.5 115.3, 180.19 135.4 Ernesto, 51.3 Aghaians, Dino, 194.12 Al Saati, Talal, 190.79 Aliyeva, Gunay, 182.5 Alt, Frederick, 123.18 Aceves-Ram´ırez, Aghayaev, Turan, Al Seesi, Sahar, 70.13 Al-Janabi, Mohanad, Alt, Frederick W., S96 Maricela, 182.40 191.12 Al Souz, Jafar, 57.17, 138.16 Altay, Gokmen, 131.18, Acharya, Munjal, Aghayev, Turan, 118.2 124.8, 128.6, 130.2 Alkarkoushi, Rasha, 182.27 182.36 Agorku, David, 134.15, Alajlan, Huda, 52.14 185.4, 190.30 Althubaiti, Nouf, 190.48 Acharya, Nandini, 194.26 Alam, Anwar, 120.7 Alkhaleel, Farrah, Altman, Amnon, 76.17 137.15 Agrawal, Anshu, Alam, Md, 68.17 53.13, 183.13 Altunay, Meltem, 187.22 Acharya, Pankaj, 60.6 125.16, 182.36 Alam, Shahid, 190.32 Allaire, Joannie, 192.3 Alvarado, Luigi, 67.11 Achenbach, Alan, Agrawal, Anurodh, Al-amri, Sawsan, Allan, David, 63.15, Alvarez, Carlos, 56.7, 185.10 139.10 139.10 181.28 190.71 Achour, Achouak, Agrawal, Madhur, Alaniz, Robert, 190.31 Allayee, Hooman, Alvarez, Maria, 190.60 65.14 182.25 Alarcon, Pablo, 73.19 122.10 Alves, Sandra, 181.12 Ackart, David, 139.1 Agrawal, Sudhanshu, Alard, Pascale, 61.13, Allegrezza, Michael, Alwayn, Ian, 69.45 Acker, Elizabeth, 62.15 67.4 178.18 138.22 Amadi, Emmanuel, Ackerman, William, Aguilar, Alicia, 51.21 Alatassi, Houda, 192.4 Allen, Christopher, 122.9 187.1, 187.2 Aguilar, Ethan, 69.36 Alazami, Anas, 52.14 123.22 Amador, Alfredo, 196.26

133 AUTHOR/SPEAKER INDEX

Amadou Amani, Anderson, Mark, 129.3, Apparailly, Florence, Assmus, Lisa, 60.7 Bachus, Holly, 56.18, Souwelimatou, 190.84 S39 50.12 Ataca Atilla, Pinar, 71.8 119.26 Amani, Souwelimatou, Anderson, Michele, Appel, Nicole, 138.20 Atalis, Alexandra, 196.7 Badea, Tudor, 52.4, 196.19 53.14 Appelman, Henry, Atamas, Sergei, 132.3 132.3 Amano,Hirofumi,183.16 Anderson, Regan, 120.31 Atasoy, Ulus, 186.13 Badovinac, Vladimir, Amara, Rama, 76.6 196.27 Appleton, Brenna, Atif, Shaikh, 63.13, 117.4, 198.7 Amara, Suneetha, 70.10 Anderson, Ryan, 64.1 116.14 182.68 Badstubner, Mareike, Ambigapathy, Ganesh, Anderson, Stephen, Aqbi, Hussein, 194.7 Atilla, Erden, 71.8 177.31 120.30 59.11 Aragon, Jordon, 182.22 Atkins, Colm, 75.15 Badten, Alexander, Ambrozak, David, 72.6 Ando, Tomoaki, 54.4, Arai, Satoko, 123.3 Atkinson, Carl, 137.5 131.32 Ameel, Cassaundra, 54.8 Arakawa, Ken, 182.88 Atkinson, Donald L., Bae, Hyunsu, 58.10, 190.36 Andrabi, Raiees, 72.8 Araujo,´ Joselio,´ 120.15 185.10 183.11 Amend, Courtney, Andreatta, Massimo, Arava, Sudheer, 115.11 Atkinson, John, 69.21 Bae, Yoe-Sik, 187.3 115.12 195.12 Araya, Paula, 52.1 Atkuri, Kondala, 130.36 Baehr, Carly, 70.18 Americo, Jeffrey, 56.19 Andresen, Thomas, Arbour, Nathalie, Attia, Zayed, 119.4 Baek, Song-Yi, 182.9 Amezcua, Caro, 129.9 71.10, 136.20 182.38, 182.66 Audiger, Cindy, 118.11 Baek, Songjoon, 125.17 Amici, Stephanie, Andrews, Sarah, 72.11, Archin, Nancie, 197.14 Audrito, Valentina, 52.2 Baek, Suk-Hwan, 52.6 119.6, 182.60, 186.9 190.45 Arciniega-Martinez, August, Avery, 55.20, Baeza Ram´ırez, Isabel, Amiel,Eyal, 64.2, 179.15 Andreyev, Alexander, Ivonne Maciel, 67.23 69.4, 140.1, 189.11, 132.11 Amieva, Manuel, 190.81 67.8 Arditi, Moshe, 67.1, S88 Bagadia, Prachi, 118.9, Amir, Mohammed, Andrieu, Guillaume, 120.4, 187.17 Aulakh, Sonikpreet, 177.23 68.11, 183.10 182.87 Arellano, Danna, 138.10 71.12, 71.13 Bagavant, Harini, Amo, Laura, 178.2, Andruszewski, David, Aren, Kathleen, 182.37 Auma, Ann, 120.32 178.15, 180.16 179.1 181.4 Arenas, Angela, 190.31 Aurubin, Carlie, 75.3, Bagdasaryan, Tatef, Amoah, Samuel, 139.17 Angel, Mathew, 139.20 Arend, Rebecca, 195.7 75.9 120.18 Amon, Lynn, 75.11 Angeles Floriano, Arguedas-Jimenez, Austin, Cary, 132.4 Bagley, Jessamyn, Amre, Devendra, 75.14 Tania, 118.18 Laura, 71.16 Avalos, Christian, 69.40 Amrein, Jennifer, 126.21 Angeles, Christina, Argueta, Donovan, 138.17, 138.21 Bagshaw, Clive, 177.31 Amritkar, Amit, 134.2, 138.1 190.15 Avci, Fikri, S161 Baguley, Joshua, 55.18 134.6 Angeletti, Davide, Arjunaraja, Swadhinya, Avery, Lyndsay, 61.9 Bagwell, C., 131.2 An, Dong Sung, 63.3 74.13, 139.20 184.5 Avina, Samantha, 60.20 Bah, Aicha, 190.79 An, Wei, 184.6 Angelo, Michael, 140.14 Armand, Philippe, Aviszus, Katja, 61.10 Bahauddin, Afrin, 68.3 An, Xiaojing, 182.31 Angiari, Stefano, 125.11 195.31 Avitzur, Yaron, 182.39 Bahmanof, Milad, 134.1 An, Xingyue, 134.2, Anguera, Montserrat, Arnett, Eusondia, 62.4, Awasthi, Amit, 124.14 Bailey, Christina, 131.26 134.6 50.2 62.11 Awasthi, Shanjana, Bailey, Keith, 51.13 Anadon Galindo, Anieto, Ezinne, 190.68 Arora, Gunjan, 126.7 64.26 Bailey, Kristina, 62.6 Carmen, 135.25, Anikeeva, Nadia, 130.21 Arora, Simran Kaur, Axtell, Robert, 68.12, Baker, James, 192.16 138.4, 138.22, 194.2 Anitelea, Toni, 61.11, 120.7 193.9, 193.15 Baker, Chandra, 128.8 Anand, Sudarshan, 61.14, 61.19 Arpag-Mcintosh, Sezgi, Ay, Ferhat, 125.4 Baker, Robyn, 192.10 194.39 Ann, Jihae, 134.7 64.10 Ayala, Julio, 55.19 Baker, Rocky, 68.5, Anastasakis, Dimitrios, Anolik, Jennifer, S209 Arriens, Cristina, 182.8 Ayasoufi, Katayoun, 182.72 187.2 Ansa-Addo, Ephraim, Arroyo, Esperanza, 56.20, 76.2, 183.19 Bakke, Brock, 70.5 Anaya, Edgar, 117.14 57.12 182.37 Aycock, Scott, 74.13 Bakre, Abhijeet, 130.19 Anderko, Renee, 76.8 Anthony,Donald,120.32 Artis, David, 191.3 Ayyappan, Prathapan, Bakshi, Mariam, 127.16 Andersen, Anna, 183.18 Anthony, Scott, 129.14, Artyomov, Maxim N., 178.5 Bal, Vineeta, 192.6 Anderson, Albert, 51.15 198.7 S200 Azad, Abul, 62.4, 62.20 Balancio, Ann J Anderson, Amy, 179.9 Antia, Rustom, 76.14, Arumugam, Rajkumar, Azarin, Samira, 138.3 Canonigo, 76.17 Anderson, Ana, 137.15, 197.18 115.3, 180.19 Azevedo, Rita, 57.2 Balboa, Luciana, S107 Antignano, Frann, 58.3, Asai, Akira, 120.14, Azuma, Miyuki, 55.10 190.79 Anderson, Christopher, 130.18 195.14 Baldwin, Cynthia, 73.23 139.24 Antillon,´ Armando, 51.3 Ashwell, Jonathan, Baldwin, Susan, 139.5 Anderson, Colin, 54.14 Antin, Joseph, 69.42 53.12 B Baldwin, William, 69.14 Anderson, Daniel, Antonchuk, Jennifer, Ashworth, Alan, 130.6 Ba, Zhaoqing, 123.18 Balgeman, Alexis, 126.37 71.3 Askanase, Anca, 182.8 Baaten, Bas, 62.8 177.29, 190.36 Anderson, Jane, 61.16 Antonucci, Laura, 125.1 Aslan, Nuray, 74.7 Babic, Ivan, 194.22 Ball, Andrew, 52.21, Anderson, Karen, Anvari, Sara, 55.21 Asokan, Babor, Mariana, 196.12 131.11 131.21 Apetoh, Lionel, 124.14 Mangaiarkarasi, 72.6 Baccarini, Alessia, Ball, Michael, 182.37 Anderson, Kathryn, Apgar, John, 188.4 Asosingh, Kewal, 119.6 138.19 Ballard, Jimmy, 190.84, 126.4 Apostol, April, 118.1 Aspromonte, Salvatore, Bachem, Annabell, 196.19 Anderson, Lindsey, Apovian, Caroline, 136.6 189.1 Ballesteros-Tato, 182.24 182.25 Asselin, Claude, 190.67 Bachman, Kay, 119.27 Andre, 56.18, 119.26

134 AUTHOR/SPEAKER INDEX

Ballweg, Matthew, Barrientos, Jacqueline, Bautista, Jhoanne, Benet, Zachary, 121.15 Bharaj, Preeti, 64.16, 139.14 182.62 129.3 Benevides, Luciana, 139.2 Bally, Alexander, 60.13 Barrington, Robert, Bautista, Bianca, 140.10 190.22 Bharat, Ankit, S33 Balsamo, Joseph, 120.21 Bawadekar, Mandar, Benmohamed, Lbachir, Bhardwaj, Vinnu, 131.38 182.59 Barrio, Alvaro, 131.4, 124.2 196.3 Bhaskaran, Natarajan, Bam, Marpe, 182.20, 131.13, 194.29 Bayik, Defne, 182.21 Bennett, Amelia, 55.20 57.15 185.4 Barron, Alexander, Bazile, Cassandra, Bennett, Hunter, 59.2, Bhatia, Nitasha, 133.16 Bamezai, Anil, 53.2, 182.49 179.13 187.21 Bhatt, Priya, 73.21 68.4, 125.7, 125.8, Barron, Bridgette, Beadenkopf, Robert, Bensing, Barbara, 130.5 Bhatta, Anuja, 184.2 186.7, 195.28 178.17 195.25 Benson, Bryan, 51.21 Bhattacharjee, Banaee, Touka, 69.46 Barros, Claudia,´ 128.19 Beaman, Kenneth, Benveniste, Etty, 52.3, Meenakshi, 193.2 Banchereau, Jacques, Barry, Michael, 177.30 129.10, 137.14 188.1 Bhattacharya, Deepta, 117.19 Barski, Artem, 125.13 Beamer, Celine, S90 Beppu, Lisa, 128.3, 118.17, 121.13, S142 Banda, Nirmal, 133.9 Barsoumian, Beard, K. Scott, 68.5 128.11 Bhattacharya, Parna, Bandey, Irfan, 134.2, Hampartsoum, 136.11 Bearwald, Christoph, Berdnikovs, Sergejs, 196.29 134.6 Barsoumian, 180.9 119.3 Bhattacharya, Bando, Jennifer, 181.28 Hampartsoum B., Beatty, Wandy, 177.23 Berdyshev, Evgeny, Sharmila, 182.13 Bandola-Simon, 71.6 Beaudin, Anna, 53.15, 190.5 Bhattacharyya, Joanna, 135.16 Bartholomaus,¨ Alina, 118.1, 118.13 Berg, Rance, 126.19 Arindam, 135.25 Bandyopadhyay, 130.27 Beaudoin, Frederic, Berger, Alexandra, Bhattacharyya, Mitra, Mohna, 133.6 Bartlett, Hannah, 61.20 73.13 71.11 140.12 Banie,Homayon,122.10 Barutello, Giuseppina, Beaulieu, Aimee, 65.4 Bergmann, Cornelia, Bhattacharyya, Sourya, Banki, Katalin, 115.6 71.4 Beaupre, Michael, 185.3 125.4 Bansal, Abhisheka, Barwick, Benjamin, 181.11 Bergsbaken, Tessa, Bhawan, Jag, 182.49 190.7 50.10, 60.13 Beauseigle, Diane, 189.8 Bhela, Siddheshvar, Bansal, Nidhanjali, Basaraba, Randall, 182.66 Bernard, Lucie, 66.2 57.18 60.19, 131.35 139.1 Beavers, Ashley, 186.8 Bernat, Nestor,´ 72.9 Bhise, Gauri, 67.24, Bansal-Pakala, Bashier, Roya, 130.23 Becca, Baby, 192.4 Bernatchez, Chantale, 189.16 Pratima, 57.9 Bashir, Ghada, 50.16, Becerra-Diaz, Mireya, 134.6 Bi, Kevin, 58.17 Bao, Jianjun, 131.1 66.9 59.15 Bernhagen, Juergen, Bi, Wenwen, 75.1 Bao, Katherine, 67.9 Bashratyan, Roman, Becher, Oren, 194.41 51.9 Bianchi, Frans, 177.7 Bao, Xiaoyong, 198.9 180.2 Beck, Emily, 53.25, Bernstein, David, 76.10 Bianchi, Joana, 57.2 Baracho, Gisele, 60.19, Bassaganya-Riera, 182.84 Bernstein, Kenneth, Biancotto, Angelique,´ 131.35, 131.37 Josep, 132.7 Becker, Kevin, 65.14 182.44 63.4 Baranov, Vladimir, 131.2 Bassani-Sternberg, Becker, Tynan, 131.39 Berrett, Hannah, 65.7 Bibicheff, Darrel, 69.32, Baranowski, Tonilynn, Michal, 70.13 Becker, William, 135.18 Berrien-Elliott, Melissa, 69.33, 116.8 190.36 Bassette, Molly, 68.11 Bedi, Sukandeep, 76.9 Bicakci, Deniz, 190.59 Baranska, Anna, 194.26 Bassham, Susan, 186.11 Bertocchi, Graciela, Bickett, Thomas, 62.12 Barber, Daniel, 190.78, 53.25, 182.84 Bedoui, Sammy, 189.1 190.60 Bieerkehazhi, 190.82 Bassiri, Hamid, 134.17 Begun, Jakob, 69.38 Bertolino, Patrick, Shayahati, 138.18 Bardini, Dhyana Iris, Bastardo Blanco, Behnamfar, Negar, 57.4 196.27 Bigini, Paolo, 196.23 63.6 Daniel, 53.5 Behnsen, Judith, 190.6 Berub´ e,´ A., 181.8 Bilenky, Misha, 55.7 Bardwell, Philip, 136.20 Basu, Srijani, 192.6 Beier, Ulf, 137.1 Berube, Bryan, 139.5 Billiar, Timothy, 183.5 Barham, Whitney, 195.1 Batich, Kristen, 70.20 Beigi Masihi, Meher, Berzofsky, Jay, 134.8 Billingsley, James, 76.6 Barichello, Tatiana, Batista, Nathalia, 140.7 194.41 Beswick, Ellen, 52.9 Bilotta, Anthony, 191.15 63.6, 120.11 Batista, Nathalia V, 74.9 Beiss, Veronique, 136.7 Bettelli, Estelle, 67.24 Bilsborrow, Joshua, Barker, Kimberly, 66.22 Batra, Dhwani, 139.17 Belaid, Djamel, 117.19 Betts, Michael, 51.5, 181.22 Barna, Barbara, 120.21, Batra, Lalit, 71.6 Belkaid, Yasmine, 128.7 121.16, 130.4, 189.7 Bimczok, Diane, 51.6, 187.20 Batty, Abel, 187.1, 187.2 Belkina, Anna, 120.6, Beura,Lalit,66.21,189.9 59.16 Barnett, John, 186.14 Batugedara, Hashini, 182.25 Beuter-Gunia, Cornelia, Binder, Robert, 59.10 Barnich, Nicolas, 192.3 185.9, 190.15 Bell, April, 137.2 126.6 Bing, So Jin, 190.54, Barnstein, Brian, 54.12 Baturin, Dmitry, 52.1 Bellemare-Pelletier, Bevan, Nicola, 130.30 193.1 Baron, Sarah, 120.16 Baudier, Robin, 139.16 Angelique,´ 184.7 Bevins, Charles, 127.10 Binger, Katrina, 189.1 Bar-Or, Amit, 189.7 Bauer, John, 57.21 Bellinger, Calli, 187.7 Bezbradica, Jelena, Biragyn, Arya, 182.35 Bar-Peled, Yael, 198.1 Bauer, Renate, 70.23 Bellinger, Shandra, 60.6 Bird, Cara, 194.10 Barr, Ian, 74.12 Baulch, Janet, 182.36 55.18 Bezman, Natalie, 76.9 Bischof, John, 138.3 Barra, Jessie, 69.19 Bauman, Bradley, 60.9 Belmonte, Paul, 68.16 Bhagat, Anchit, 187.16 Bishop, Gail, 123.2 Barragan, Jessica, Bauman, Bradly, 184.5 Bendix, Maura, 71.11 Bhandari, Rajan, Bissonnette, Nathalie, 133.2 Baumgarth, Nicole, Bendzick, Laura, 136.22 135.17, 182.37 73.13 Barrat, Franck, 180.18 75.25, 123.21 Benedict, Stephen, Bhandoola, Avinash, Biswas, Nivedita, Barrett, Nora A., S141 Baur, Joseph, 137.1 184.2 53.1, 134.3 135.27

135 AUTHOR/SPEAKER INDEX

Biswas, Subir, 135.25, Bodduluri, Sobha, 192.4 Bossowska-Nowicka, Bram, Richard, 195.24 Brooks, David, 197.10 138.4, 138.22, 194.2 Bodogai, Monica, Magdalena, 64.11 Brand, Timothy, 130.11 Brooks, Steve, 191.18 Bitoun, Jacob, 192.1 182.35 Boswell, Andy, 131.19 Brandacher, Gerald, Broski, Annalisa, Bitsaktsis, Constantine, Bogdani, Marika, 207.1 Botelho, Michael, 127.4 69.32, 69.33, 116.8 196.30 139.9 Bohannon, Caitlin, Bothner, Brian, 180.8 Brandfald, Michaela, Brothers, Shannon, Bivona, J.J., 187.26 139.17 Bottini, Nunzio, S169 181.4 52.14 Bjoergen, Haavard, Boiarsky, Jonathan, Bouchard, Michael, Brandon, Wong Han Brovarney, Martin, 119.5 73.6 134.13 190.67 Siang, 138.12 Brown, Brian, 136.4, Bjorkman, Pamela, Boisvert, Natalie, 73.23 Boucher, Justin, 179.13 Brandt, Ludwig, 131.29 138.19 177.6 Bolaños, Natalia, 126.26 Boudina, Sihem, Brandt, Stephanie, Brown, Brittany, 131.6, Bjorkstr¨ om,¨ Niklas, Boldin, Mark, 53.22 185.10, S162 183.17 131.24, 131.25, 51.5, 189.7 Bolland, Silvia, 123.1, Boudinot, Pierre, 121.17 Brar*, Harvinder, 120.13 131.28 Black, Carolyn, 126.32 178.1, 178.2, 179.1 Bouladoux, Nicolas, Brar, Gurpreet, 62.8 Brown, Deborah, 61.7, Black, Paul, 58.18 Bollela, Valdes, 125.10 128.7 Brate, Ashley, 115.9, 139.14 Blackwell, Anne-Gaelle, Bollino, Dominique, Boulares, Hamid, 119.9 193.11 Brown, Jared, 54.14 139.19 194.43 Boulougoura, Afroditi, Bratic*, Nemanja, Brown, Josephine, Blaine, Kelly, 67.22, Bollyky, Paul, 52.15, 182.88 120.13 178.12 119.25 119.14 Bourdon, David, 130.35 Brauner, Janina, 134.15 Brown, Lindsey, 195.25 Blais, Mylene, 73.13, Bolte, Ashley, 187.7 Bourguet, Feliza, 75.24 Bravo-Perez, Daniel, Brown, Melissa A., S16 190.67 Bomberger, Jennifer, Bourque, Marie-Josee,´ 131.19 Brown, Michael, 76.5 Blake, Harrison, 126.10 182.81 177.27 Brayton, Cory, 52.13 Brown, Stephan, Blalock, Emily, 50.10 Bommareddy, Praveen, Boutet, Stephane, Brazeal, Kathleen, 61.7 129.11 Blanchard, Emmeline, 136.6 131.4, 194.29 Brea, Eliott, 134.13 Brown, William, 190.31 196.7 Bommireddy, Bouyer, Donald, Break, Timothy, 128.7 Browning, Jeffrey, Blanchard, Eugene, Ramireddy, 70.7, 190.25, 190.37 Bream, Jay, 52.13 182.49 193.2 71.2 Bowen, Claire, 52.14 Breed, Elise, 53.11, Browning, Lauren, 52.5 Blanchette, Craig, Bonami, Rachel, Bowen, David, 196.27 53.16 Bruiners, Natalie, 125.19 130.21, 132.4 115.14, 178.17 Bowen, William S., 71.6 Breen, Michael, 198.14 Brulet, Jeffrey, 71.7 Blanchfield, Lori, 115.18 Bonenfant, Jeffrey, Bowers, Emily, 118.6 Brehm, Michael, 126.37 Brumer, Harry, 192.19 Blanco, Jesus, 132.17 120.22 Bowlus, Christopher, Brenner, Malcolm, 71.8 Bruni, Cassi, 59.2, Blanco, Luz, 182.21 Bonissone, Stefano, 179.3 Brenner, Michael, S209 187.21 Blasi, Maria, 58.18 123.16, 131.23 Boyaka, Prosper, 55.4, Breshears, Melanie, Bruno, Tullia, 138.15, Blattman, Joseph, 66.6, Bonneau, Richard, 119.4 64.26 195.9 130.13, 131.21, 75.11 Boyd, David, 74.12 Brewer, David, 61.6 Brust-Mascher, Ingrid, 138.20, 197.18 Bonnegarde-Bernard, Boyd, Lisa, 177.15 Brewer, Guy, 139.5 66.16 Blazar, Bruce R., 69.10, Astrid, 55.4 Boyden, Alexander, Brickey, June, 64.12 Brutkiewicz, Randy, 69.35, 69.38, 69.42, Boo, Kyung-Jun, 119.8 115.9 Brickner, Joshua, 177.16 135.6, 194.6, S114 Boodhoo, Dallas, 52.4 Boyer, Mark, 62.1 177.23 Bryant, Clare E., S77 Blenman, Kim, 136.25 Boom, W Henry, 64.24 Boyer, Olivier, 179.6 Brieschke, Brigitte, Bryce, Paul, 126.1 Blethen,Kathryn, 186.14 Booshehri, Laela, 125.1 Boyle, David, 57.4 70.21 Bryceson, Yenan, 65.6, Blish, Catherine, S78 Boothby, Mark, 186.17 Boyson, Jonathan, Brill, Jacob, 177.32 76.10 Bliss-Moreau, Meghan, Boras, Valerie, 192.19 53.21, 65.13 Briney, Bryan, 72.8 Brzostek, Joanna, 189.6 59.4 Borges da Silva, Brabbs, Stuart, 56.6 Brink, Marcel, 69.10 Bshara-Corson, Blixt, Martin, 182.53 Henrique, 56.13 Braciale, Thomas, Brinkworth, Jessica, Savannah, 52.18 Blom, Anna, 137.13, Borges, Valeria, 190.42 129.18 73.21 Bu, Xia, 195.31 S100 Borghesi, Lisa A., S24 Brackett, Craig, 182.70 Briscoe, David, 69.13 Bucala, Richard, 51.9, Blomberg, Bonnie, Borne, Adam, 71.7 Bradford, Delia, 119.5 Briseño, Carlos, 177.23 180.13 121.8, 179.4 Boronina, Tatiana, Bradford, Jolene, 131.41 Bristol, Neil, 51.20 Buchsbaum, Donald, Blossom, Sarah, 50.7 177.14, 177.18 Bradford, Shelby, 59.13 Brix, Liselotte, 131.4, 195.7 Bluestone, Jeffrey, Borst, Oliver, 126.25 Bradfute,Steven,197.23 131.13 Buck, Jessica, 73.23 133.2, 181.4 Bose, Abhishek, 126.17 Bradley, Brenda, 68.5 Brock, Rebecca, 67.7, Buckley, Eilish, 61.20 Bluher,¨ Matthias, 182.51 Bosenberg, Marcus, Bradley, David, 135.27, 182.30, 194.31 Buckner, Jane, 178.5 Blum, Samuel, 178.7 136.25 196.24 Brockstedt, Dirk, 119.5 Buckner, Jane, S16 Blume, Jonas, 57.19 Bosinger, Steve, 76.6 Bradley, Linda, 117.25, Brody, Joshua, 70.9, Bucsek, Mark, 195.23 Blurton-Jones, Mathew, Bosio, Catharine, 67.16 140.6, 187.36, 194.41 136.4, 136.19, 138.19 Buddhadev, Stuti, 136.6 193.10 Bosman, Else, 192.3 Bradley, Nicole, 126.11, Brooke, Christopher, Budhu, Sadna, 136.23, Bobardt, Sarah, 190.15 Boss, Jeremy, 50.10, 140.22 139.20 137.3 Bochicchio, Grant, 51.10, 60.13, 123.8, Bradner, Jay, 69.42 Brookmeyer, Kathryn, Buechel, Heather, 118.3 188.2, 188.9, 188.15 Brady, Lauren, 195.10 192.16 122.3, 128.3 Boczkowski, David, Bossler, Aaron, 178.13, Braile, Mariantonia, Brooks, Stephen, Buekars, Thomas, 136.9 178.14 126.16 181.27 135.30

136 AUTHOR/SPEAKER INDEX

Bueno Filho, Roberto, Byeon, Yeongseon, Caminschi, Irina, 196.27 Carlson, Louise, 121.7, Castonguay, Catherine, 52.23 182.85 Camiolo,Matthew,119.1 123.11 140.10 Buetow, Kenneth, Bynoe, Margaret S., Campbell, Edward, Carlsson, Per-Ola, Castro, Ricardo, 125.10 177.32 116.11,S157 69.37 182.47, 182.53 Catalfamo, Marta, Buffolo, Marcio A., Byrne-Steele, Miranda, Campbell, Daniel, 51.7, Carlyle, James, 63.15, 56.11, 72.13, 72.14, 185.10 131.6, 131.24, 52.16, 128.4, 207.1 181.28, 187.8 120.24, 181.23 Buford, Mary, 117.6 131.25, 131.28 Campbell, Evelyn, 67.6 Carmena Moratalla, Cattin-Roy, Alexis,181.1 Buggert, Marcus, 51.5, Byrum, Jennifer, 53.24 Campbell, Heather, Ana, 182.66 Cattley, Russell, 55.16 121.16, 189.7 Byrum, Stephanie, 50.7 195.23 Carmona, Eva, 190.20 Caudle, Yi, 57.1 Buhimschi, Irina, 187.1, Byun, Hae-Ok, 117.24 Campbell, James, 133.7 Carnes, Henry, 190.34 Cauley, Linda, 60.17, 187.2 Campbell, Michelle, Carnevale, Julia, 130.6 66.24, 129.9 Bui, Jack, 181.21 123.23 Carney, Paul, 139.17 Cavalli,Florence,194.41 Bui, Nhi, 196.17 C Campbell, Phil, 69.1 Carns, Mary, 182.37 Cayrol, Corinne, 119.29 Bulysheva, Anna, 64.10 Cabana-Puig, Xavier, Campbell, Sean, 68.11, Carpenter, Dustin, 129.8 Cazenave-Gassiot, Bunnell, Stephen, 184.1 178.10, 178.11 71.7, 183.10 Carpenter, Katherine, Amaury, 122.3 Bunz, Maximilian, Cacicedo, Jose, 182.25 Campesato, Luis 137.7 Cecere, Thomas, 140.15 Cadena, Alexandra, Felipe, 137.3 Carpenter, Susan, S77 50.13, 178.10, 178.11 Burbach, Brandon, 136.11 Campos-Rodriguez, Carpio, Victor, 190.28 Cekanaviciute, Egle, 138.3 Cadena, Anthony, Rafael, 67.23 Carr, Daniel, 75.19 182.13 Burdelya, Lyudmila, 190.33 Campwala, Hinnah, Carr, William, S30 Celis, Esteban, 195.26 182.70 Cadwell, Ked, 190.6 130.30 Carregaro, Vanessa, Cella, Marina, 181.28 Burdine, Marie, 69.26 Cadwell, Ken, 131.3, Camus, Mylene,` 119.29 52.23, 140.20, 190.22 Celli, Jean, 190.6 Burel, Julie, 120.20, 191.9 Canaday, David, 62.14, Carreño, Leandro, 177.1 Cemazar, Maja, 64.10 130.26, 190.50 Caetano, Mauricio, 120.10, 121.16, Carrette, Florent, 194.41 Centore, Joshua, 116.15 Burg, Ashley, 178.7 136.11 140.17 Carrington, Mary, 120.3 Cepeda, Sergio, 65.16 Burgos da Silva, Caffi, Valeria, 73.19 Canatan, Halit, 193.12 Carrithers, Michael, Cepeda, Sergio, 115.25 Marina, 69.34 Cagigi, Alberto, 72.11 Canducci, Filippo, 178.8 182.71 Cephus, Jacqueline, Burkhardt, Amanda, Cahalan, Michael, Cannoles, Kirsten, Carroll, Michael C., S77 119.16 131.32 193.10 190.59 Carter, Chavez, 55.20 Cervantes, Rodrigo, Burlet-Schiltz, Odile, Cai, Jinjin, 185.10 Cannon, Paula, 72.8 Carter, Hannah, S153 190.81 119.29 Cai, Jiyang, 190.25 Cannon, Tyler, 177.27 Carter, Mark, 52.22 Cescato, Margaux, 66.2 Burmeister, Brock, Cai, Shanshan, 62.17 Canter, Robert, 126.27 Carter, Martha, 197.11 Chacon-Salinas,´ 196.8 Cai, Yi, 122.6 Cantin, E., 197.7 Carter, Rebecca, 66.8 Rommel, 179.7 Burns, Jane, 182.61 Cait, Jessica, 55.7 Cantin, Edouard, 63.3 Cartwright, Emily, 129.2 Chai, Louis, 71.1, 130.1 Burns, Jane, 57.4 Cakir, Mustafa, 193.12 Cantor, Harvey, SAP5 Caruso, Santina, 136.20 Chakhtoura, Marita, Burr, Abigail, 185.9 Calbo, Sebastien,´ 179.6 Cantrell, Jason, 131.16, Carvalho, Kleyton, 180.17 Burr, Ansen, 192.10 Calderon, Veronica, 131.20 136.10 Chaki, Sankar, 190.31 Burrack, Adam, 134.9 57.21, 130.16 Cao, Guoshuai, 195.20 Casali, Paolo, 121.11, Chakrabarty, Sagarika, Burrows, Amy, 185.3 Calderon-Colon, Cao, Jianhong, 135.3 123.14, 182.78, 195.6 186.10 Burt, Trevor, 124.9, Xiomara, 68.15 Cao, Jianping, 190.83 Casanova, Israel, 55.19 Chakraborty, Abhijit, 191.17 Cali, James, 52.19 Cao, Jin, 63.15 Cascio, Sandra, 135.5 123.15 Burton, Dennis, 72.8 Callison, Sharon, Cao, Liang, 190.5 Case, Elizabeth, 190.31 Chakraborty, Paramita, Burton, Dennis, S6 131.28 Cao, Ling, 182.46, Case, Laure, 132.14 137.5 Busbee, Brandon, Calmettes, Guillaume, 182.63 Casella, Giacomo, 50.18 Chakraborty, Rana, 191.10 63.3 Cao, Weiping, 139.17 Casero, David, 118.10 126.28 Busbee, Philip, 192.12 Camacho, Daniel, Cao, Wenqiang, 71.15 Cashin, Philippa, 61.16 Chakravarti, Ritu, 182.6 Busch, Hauke, 178.3 119.25 Cao, Yi, 132.4 Casillas-Muñoz, Fidel, Chakravarty, Bush, Erin, 60.5 Camacho, Virginia, Capilla, Florence, 66.2 182.40 Debanjana, 126.9, Bushar, Nicholas, 118.14 Capitini, Christian, 69.39 Caslin, Blaine, 193.5 126.17 186.10 Camacho-Hernandez, Capozzoli, Benjamin, Caslin, Heather, 64.9 Chakravarty, Rekha, Butchar, Jonathan, Alejandro, 68.10, 195.28 Caspi, Rachel, 116.6, 195.17 59.12 70.17, 131.17 Cappello, Paola, 71.4 120.26, 190.54, Chalfant, Charles, 64.9 Butcher, Eric, 52.1 Cambier, John, 121.14, Carambula, Roy, 133.4 191.5, 191.6, 193.1, Chamberlain, Mathew, Butcher, Matthew, 182.68 Carannante, Valentina, 193.7 131.15 128.12 Camblin, Adam, 195.11 131.29 Castañeda-Casimiro, Chambers, Michael, Butchy, Adam, 71.18 Camell, Christina, S168 Carbasse,Aurelia, 50.12 Jessica, 190.86 190.45 Buteyn, Nathaniel, Cameron, Joshua, Cardani, Amber, 129.18 Castellana, Natalie, Chan, Leo, 130.8 59.12 187.15 Care, Matthew, 123.7 123.16 Chan, Marcia, 184.2 Butler, Noah, 190.26 Cameron, Cheryl, Carey, Kaylin, 52.7, Caster, Courtney, 73.2 Chan, Sara, 132.4 Butts, Cherie´ L., S49 140.17 52.8, 181.14, 181.17, Castillo, Eliseo, 128.2 Chan, Syed, 130.26 Buzzai, Anthony, 138.2 Cameron, James, 179.9 194.36 Castillo, Patricia, 191.16 Chan, Timothy, 137.11

137 AUTHOR/SPEAKER INDEX

Chanan-Khan, Asher, Charpentier, John, Chen, Dexi, 194.16 Chen, Yu-Kai, 135.19 Cho, Jae-Ho, 189.4 71.12, 71.13 125.14 Chen, Elijah, 189.6 Chen, Zhiwei, 75.22, Cho, Jun Hwi, 58.7, Chanana, Pritha, Chase, Carol, 193.8 Chen, Eugene, 131.19 195.13, 197.19 195.19 194.19 Chateau, Morgan, 72.8 Chen, Grace Y., S77 Cheng, Alfred, 195.13 Cho, Nam-hyuk, 117.2 Chanda, Sumit, 197.4 Chatham, W., 179.5 Chen, Guobing, 65.14 Cheng, Allen, 74.12 Cho, Nam-Hyuk, 190.25 Chandiran, Karthik, Chatham, Winn, Chen, Guo-Yun, 64.17 Cheng, Chao, 138.1 Cho, Okki, 52.11 60.17, 66.24 179.10, 182.8 Chen, Hui, 56.11 Cheng, Jie, 72.13, Cho, Sung, 186.17 Chandra, Shilpi, 65.1 Chatterjeea, D, S30 Chen, Hung-Lin, 183.1 181.23 Cho, Sunjung, 181.6 Chandra, Tarun, 182.8 Chatterjee, Arindam, Chen, Jake, 179.5 Cheng, Jun Fang, 73.22 Cho, Yong-Bin, 56.22 Chandra, Vivek, 125.4 137.7 Chen, Jiachen, 191.1 Cheng, Liang, 75.1 Cho, Yoon-Jae, 194.41 Chandran, Chatterjee, Shilpak, Chen, Jiangye, 190.16 Cheng, Ni, 187.4 Choa, Ruth, 58.8 Ramakrishna, 197.7 137.5 Chen, Jie, 182.29 Cheng, Xi, 192.4 Chock, Cameron, 128.2 Chandrashekarappa, Chattopadhyay, Pratip, Chen, Jinya, 120.24 Cheng, Zhenyu, 127.2 Choe, Jongseon, 125.9 Sandeep, 192.4 194.21 Chen, Joyce, 134.3 Chernyak, Natalia, Choi, Dong-Hoon, Chandy, K. George, Chattopadhyay, Chen, Jueqi, 63.8 134.7 189.15 138.12 Saurabh, 75.10 Chen, Jun, 116.6, 193.7 Cheroutre, Hilde, 53.3, Choi, Eun, 126.40 Chang, Cheng-Yen, Chatzistamou, Ioulia, Chen, Kong, 131.30, 62.18, 67.18, 124.3, Choi, Eun-Jin, 198.9 194.23 185.4, 190.30 139.7, 139.8, 182.31 129.7, 140.4, 191.11 Choi, Hyejin, 134.13 Chang, Cheong-Hee, Chaudhari, Sweena, Chen, KuanHui, 137.6 Cherry, Sara, S199 Choi, Jae Eun, 126.30, 65.9, S91 68.11 Chen, Ligong, 58.5 Chesler, Louis, 194.41 137.11 Chang, Cherng- Chaudhary, Khushboo, Chen, Lujun, 195.8 Chesson, Brent, 136.6 Choi, Je-Min, 193.4 Shyang, 191.8 183.9 Chen, Meng, 55.1 Cheung, Foo, 63.4 Choi, Jin Kyeong, Chang, Chia-Shiang, Chaudhary, Neelam, Chen, Michelle, 183.15 Cheung, Kei-Hoi, 130.26 123.10, 180.6 57.16, 74.4 130.13, 131.21 Chen, Minhui, 136.27, Chevassus, Hughes, Choi, Nicholas, 121.12 Chang, Christina, 131.40 Chaudhary, Vidyanath, 195.23 50.12 Choi, Seung-Chul, Chang, Christopher, 127.4, 180.18 Chen, Mong-jen, 132.12 Chhabra, Anita, 178.18 66.19, 115.7, 116.4, 54.9 Chaudhuri, Evan, Chen, Ping, 72.13 Chhina, Vicky, 133.7 132.6, 178.12 Chang, De-Kuan, 71.10 136.18 Chen, Priscilla, 71.3 Chi, Ellen, 57.9 Choi, Wanho, 118.4, Chang, Fen-Lei, 165.1 Chauhan, Anil, 188.13 Chen, Rong, 135.11 Chi, Hongbo, 53.5 119.24, 177.4, 177.13 Chang, Hui-Hsin, 124.2 Chaurasia, Bhagirath, Chen, Shuang, 67.1 Chia, Jean-San, 138.8 Choi, Yeo Jin, 134.20 Chang, Hye Young, 185.10 Chen, Siqi, 70.12, Chiale, Carolina, 196.18 Choi, Yongwon, 126.22 75.23 Chaurio Gonzalez, 134.7, 195.21 Chian, David, 119.5 Choi, Youn Soo, 179.11 Chang, Jessie, 139.17 Ricardo, 138.4, Chen, Sisi, 133.10 Chiang, Jeffrey, 183.13 Choi, Yun Hwa, 117.13, Chang, John, 60.14 138.22, 194.2 Chen, Tianmeng, 183.5 Chiarella, Sergio, 119.3 121.10 Chang, Jonathan, Chavan, Sangeeta, Chen, Tse-Ching, Chiba, Kenji, 132.1 Chong, Anita, 69.12, 187.21 133.17 57.16, 74.4 Chicana, Betsabel, 69.20 Chang, Min-Kyung, Chavel, Colin, 118.15, Chen, Wangxue, 139.13 188.16 Chong, Fenny, 182.69 133.13 123.11 Chen, Weiwei, 122.4 Chicco, Maria, 69.32, Chong, Wai Po, 116.6, Chang, Shih-Hsin, Chawdhury, Fatema, Chen, Wendy, 69.46 69.33, 116.8 193.1, 193.7 182.34 120.3 Chen, Xi, 63.15, 70.14, Chigor, Vincent, 122.9 Chongsathidkiet, Chang, Shin-Wen, Chawla, Amanpreet 130.5, 190.46 Chihara, Norio, 124.14 Pakawat, 138.5, 118.3 Singh, 188.19 Chen, Xia, 56.4 Childs, Porscha, 61.6 186.15 Chang, Theresa, 66.5 Chawla, Karan, 75.10 Chen, Xian, 197.4 Chimote, Ameet, 132.8, Chou, Chun, 53.23 Chang, Ti-Cheng, 74.6 Chelluri, Lakshmi Kiran, Chen, Xian-Ming, 195.34 Chou, Ting-Fang, 62.18 Chang, Yu-Ling, 120.13 190.12 Chimski, Paul, 73.2 Chou, Yushang, 134.7 122.15, 126.30 Chelvanambi, Manoj, Chen, Xiaohua, 69.5 Chinnaiyan, Arul, 137.11 Choudhary, Gourav, Chang, Yung, 70.22 194.27 Chen, Xiaoting, 125.13, Chinthrajah, Sharon, 115.6 Channappanavar, Chen, Cheng, 192.16 197.11 196.1 Choudhury, Biswa, Rudragouda, 198.4 Chen, Alyce, 59.4 Chen, Xinchun, 122.6 Chiorazzi, Nicholas, 190.46 Chao, Ti-chun, 185.1 Chen, Angeline, 53.3, Chen, Xiqiang, 190.83 182.62 Chouker,` Alexander, Chapell, Elizabeth, 62.8 129.7, 140.4 Chen, Xiufen, 135.6, Chiou, Joshua, 185.1 182.15 Chapes, Stephen, 123.6 Chen, Aoshuang, 135.21 Chirra, Martina, 195.34 Chow, Kay, 130.24, Chapman, Brittany, 196.30 Chen, Yidong, 195.5, Chitko-McKown, Carol, 130.25 118.8 Chen, Changrong, 195.29 187.13 Chow, Sheryl, 187.15 Chapman, Harold, 50.6, 136.12 Chen, Yi-Guang, 50.9, Chiu, Mei Sum, 195.13 Christensen, Ken, 115.8, 115.15 Chen, Chien-Sin, 117.3 115.20, 116.9, 178.7 Chiu, Yen-Ling, 138.8 196.16 Chapoval, Svetlana, Chen, Ching-Chow, Chen, Yim Ling, 60.5 Cho, Byungrae, 51.20 Christian, David, 122.5, 186.4 117.12 Chen, Ying Jen, 120.34 Cho, Chi, 193.16 190.11, 190.44 Chappell, Elizabeth, Chen, Chunxia, 69.23 Chen, Ying-Han, 131.3 Cho, Hong R., 190.55 Christian, Elena, 137.15 129.13 Chen, Clark, 194.6 Chen, Yuan, 124.1 Cho, Hongsik, 133.18 Christianson, Greg, Charo, Israel, 133.7 Chen, Der-Yuan, 182.34 Chen, Yuanzhong, 69.11 Cho, Hyeseon, 67.11 132.14

138 AUTHOR/SPEAKER INDEX

Christie, John, 138.20 Clement, Cristina, Conforti, Laura, 132.8, Coulon, Pierre- Criswell, Stacey, 69.9 Christman, John, 119.19 177.21 195.34 Gregoire, 196.3 Croft, Michael, 119.17, Christo, Susan, 138.2 Clenet, Marie-Laure, Cong, Yingzi, 191.15 Coupland, Lucy, 183.3 119.20 Christoffersson, Gustaf, 181.8 Connolly, Audrey, 184.7 Courtney, Amy, 195.27 Croker, Ben, 59.4 117.5 Clenet,´ Marie-Laure, Connors, Thomas, Coussens, Paul, 117.21 Crompton, Peter, 126.7, Christopher, Ronald, 182.38 67.21 Coutermarsh-Ott, 190.45 119.31 Cloud, Natalee, 62.15 Conrad, Douglas, 182.1 Sheryl, 67.7, 194.30, Cromwell, Evan, 51.20 Christsensen, Jan, Clouston, Andrew, 69.38 Contreras, Diana, 194.31 Cronk, John, 76.5 129.2 Cluff, Emily, 194.37 119.16 Coutinho-Silva, Cronkite, Alex, 131.3 Chronopoulou, Efthalia, Clutter, Emily, 139.19 Cook, Donald, 51.14, Robson, 185.15 Crooke, Stephen, 60.12 184.6 Co, Pierre, 127.18 117.1, 119.18, 119.23 Coutri, Jenna, 194.31 Crosby, Catherine, Chu, Junjun, 51.1 Coady, Alison, 190.46 Cooper, Kirsten, 53.9 Couturier, Jacob, 193.2 119.31 Chu, Kuan Lun, 74.9 Coarfa, Cristian, 194.17 Cooper, Laurence, Covey, Lori, 58.9, Crossman, David, Chu, Manman, 120.17 Cobb, Brian, 56.7, 134.2 186.16 179.10 Chu, Shaoyou, 70.21 117.18, 190.71, S161 Cooper, Max, 73.1 Covey, Todd, 136.19 Crother, Timothy, 67.1, Chu, Shenghui, 192.7 Cobucci, Ricardo, Cooper, Megan A., Cowper, Shawn, 136.25 120.4, 187.17 Chua, Brendon, 74.12 136.10 S160, S39 Cox, Bryan, 71.1, 130.1 Crothers, Jessica, Chua, Yu Cheng, 196.27 Coburn, Lori, 117.20 Cooper, Rachel, 187.26 Cox, Jesse, 135.15 192.5 Chuang, Huai-Chia, Coch, Christoph, 198.12 Cooper, Sara, 195.7 Cox, Maureen, 117.17 Crotty, Shane, 138.6, 124.7, 132.2 Cockburn, Alana, Cooper, Vaughn, 190.49 Coyne, Carolyn B., 196.12 Chukwu, Chinwendu, 61.14, 61.15, 61.16 Corkey, Barbara, 182.25 S199 Crow, Mary, 50.8 196.7 Cockburn, Ian, 122.1, Corley, Katherine, Cozijnsen, Anton, Crowe Jr., James, S199 Chun, Hye Rin, 119.24 122.14 178.14 196.27 Crowley, Andrew, 72.6 Chung, Doohyun, 122.7 Coden, Mackenzie, Cormier, Stephania, Crabtree, Jackelyn, Crucian, Brian, 182.13, Chung, Eui-Hwan, 64.1 119.3 124.5, 198.11 198.1 182.15 Chung, Lawton, 190.6 Coello, Daniel, 67.20 Cornaby, Caleb, 115.7, Cramer, Robert, 58.1 Cruz Morales, Elisa, Chung, Sangwoon, Cohen, Ezra, 134.1 116.4, 132.6 Crampton, Steve, 129.4 119.19 Cohen, Jeffrey, 76.16 Cornelison, Garrett, 178.1, S49 Csoti, Agota, 131.9 Chupp, Daniel, 121.11, Cohen, Rachel, 192.8 70.21 Crane, Meredith, 62.10, Cua, Daniel, 115.1 182.78, 195.6 Colas, Christophe, Cornwall, Douglas, S101 Cuadrado-Castano, Chupradit, Koollawat, 119.5 190.77 Cranmer, Lisa, 66.10 Sara, 136.4 63.3 Colbert, Robert, 133.11 Correa, Luis, 51.21 Cravo, Emma, 115.6 Cudrici, Cornelia, 52.4 Cicero-Sabido, Raul,´ Cole, Kathryn, 135.15 Correa, Ricardo, 185.16 Crawford, Emily, 191.17 Cuellar, Adriana, 190.86 Cole, Lisa, 134.7 Corselli, Mirko, 189.18 Crawford, James, 133.3 126.26 Ciecko, Ashley, 115.20, Cole, Robert, 177.14 Cortes, Gabriela, 196.7 Crawford, Jeremy, 74.6, Cui, Cheng, 116.3 116.9 Coleman, Cara, 194.7 Cortese, Mario, 196.12 74.12, 134.14 Cui, Haiyan, 177.32 Ciemielewski, Jason, Coler, Rhea, 139.5 Cortez, Maria Angelica, Crawford, John, 194.41 Cui, Kaijun, 117.9 133.4 Collas, Philippe, 60.11 136.11 Crawford, Michael, Cui, Weiguo, 75.3, Cieslik, Marcin, 137.11 Collier, Ai-ris, 182.64 Corti, Marcelo, 190.79 57.11, 57.13 115.20 Ciferri, Claudio, 131.19 Collier, Rashad, 61.12 Corwin, William, 58.15 Crawley, Angela, 64.23 Cui, Xiao-Long, 53.19 Cillo, Anthony, 138.15, Collin, Mattias, S161 Cosimi, A., 69.8 Creasy, Caitlin, 134.6 Cully, Michelle, 137.1 195.9 Collins, Christopher, Coskun, Fatma, 182.32 Creissen, Elizabeth, Cumba Garcia, Luz, Cippa, Pietro, 69.8 182.8 Cosorich, Ilaria, 178.8 62.12 194.19 Ciric, Bogoljub, 50.18 Collins, Cortney, 194.37 Cossette, Patrick, 181.8 Cren, Ma¨ılys, 50.12 Cundiff, Jennifer, 190.6 Clark, Curtis, 195.17, Collins, Natalie, 58.17 Costa, Alex, 188.17 Cresko, William, 53.25, Cunha, Fernando, 195.29 Collins, Sean, 127.10 Costabile, Maurizio, 182.84 190.22 Clark, Emily, 179.13 Collodel, Allan, 63.6 61.2, 61.3, 61.4, 61.5 Criado-Moronati, Elvira, Curcio, Claudia, 71.4 Clark, Joan, 60.7 Colom, Andre,´ 66.2 Costanzo, Anne, 120.33 194.26 Curiel, Tyler, 75.17, Clark, Joseph, 122.5 Colon, Maria, 127.21 Costich, Tara, 138.4 Crinklaw, Austin, 136.3, 136.14, Clark, Matthew, 68.14 Colonna, Marco, 181.28 Costich, Tara Lee, 131.27 136.15, 137.8, 195.5, Clark, Trevon, 192.1 Colpitts, Sarah, 71.11 194.2 Criscitiello, Mike, 73.2, 195.16, 195.17, Clarke, Julie, 191.4 Colvin, Kelley, 52.1 Costin, Adam, 60.7 73.3, 190.61 195.29 Clarke, Sandra, 73.15, Combs, Colin, 120.30 Cottrell, Jessica, 58.14 Crish, James, 58.4, Curran, Michael, 185.2 191.18, 192.19 Comet-Boyaka, Estelle, Cotugno, Nicola, 72.11 127.7 Currey, Mark, 182.84 Clarke, Scott, 57.21 55.4, 119.4 Couch, Brian, 61.7 Crisler, William, 64.19 Curto, Roberta, 71.4 Clarkson, Ben, 180.1 Compton, Benjamin, Coughlin, Paige, 126.3 Crispim-Freitas, Cushman, Taylor, Clauson, Morgan, 126.2 134.8, 196.27 Cougnoux, Antony, Janaina, 136.10 136.11 Clayton, Frederic, Conchon, Sophie, 70.14 133.11 Cristina Seminario, Cusick, John, 194.12 120.31, 182.83 Conejo-Garcia, Jose, Cougoule, Celine, Maria, 184.1 Cutler, Corey, 69.42 Clemens, Bridie, 74.12 135.25, 138.4, 190.79 Cristinziano, Leonardo, Cutler, Gene, 119.5 Clemens, Elene, 74.13 138.22, 194.2, S17 Cougoule, Celine,´ 66.2 126.16 Cyr, Terry, 139.13

139 AUTHOR/SPEAKER INDEX

D Das, Arundhoti, 53.1, delaTorre,Brian,186.12 Delong, Jonathan, 122.5 Devalraju, Kamakshi 134.3 de Lacerda, João, 57.2 Delong, Thomas, Prudhula, 181.19 D’Cruz, Louise M., Das, Dayasagar, 115.11 De Leo, Alessandra, 182.72 Devarajan, S169 Das, Jugal, 56.1 58.18 Delpont, Marion, 50.12 Priyadharshini, Da Costa, Andreia, 57.8 Das, Pankoj, 73.5 de Oliveira, Camila, Delpoux, Arnaud, 138.6 140.10, 198.5 da Silva Antunes, Das, Sabyasachi, 73.1 190.21 DeMarino, Catherine, DeVault, Victoria, 53.21 Ricardo, 196.12 Das, Subha, 69.1 De Paris, Kristina, 76.11 75.16 Devenney, Kyle, 139.9 da Silva, Claudia,´ 57.2 Dasari, Harika, 190.20 de Paula Alves Sousa, Demeules, Melanie,´ Devergne, Odile, Daftarian,Pirouz,195.35 Dash, Chandravanu, Alessandra, 193.14 179.6 182.38 Dagda, Raul, 126.39 136.18 De Plaen, Isabelle, Demir, Necdet, 59.14 DeVette, Christa, 195.12 Dagley, Michael, 60.7 Dash, Pradyot, 74.12 192.14 den Hartigh, Andreas, DeVincenzo, John, Dagostin, Caroline, Daubener,¨ Walter, de Rinaldis, Emanuele, 63.12 124.5, 198.11 63.6 190.62 131.15 DeNardo, David G., Devlin, Cooper, 131.3 Dahlgren, Madelene, Daugherty, Matthew, De Rossi, Andiara, S142 Dey, Anup, 138.6 129.1 127.15, 197.20 181.12 Deng, Jiehui, 134.13 Dey, Ranadhir, 196.29 Dai, Bingbing, 132.4 D’Auria, Sabato, 52.2 De Santana, Alynne Dhaliwal, Sandeep, Dai, Hu, 177.19 Deng, June, 195.29 Karen, 52.23 179.3 Dai, Rujuan, 50.4, 50.13 Davalos, Rafael, 67.7, Deng, Liang, 197.8 Dhanda, Sandeep, Dai, Yang, 180.2 194.31 de Silva, Aruna, 76.12, Deng, Meihong, 183.5 131.16, 131.20 Dai, Yao, 51.13 David, Michael, 194.20 120.20, 140.11, Deng, Meng, 64.12 Dhume, Kunal, 122.8 Daigneault, Audrey, David, Sunil, 62.14, 140.14 Deng, Silu, 190.12 181.8 120.10 De Veaux, Nicholas, Deng, Tianda, 186.2, Dhupar, Rajeev, 187.23 Dailey, Jordan, 54.12 Davidson, Bryan, 131.5 75.11 188.8 Di Nardo, Anna, 54.16, Dakshinamoorthy, Davidson, Jesse, De, Supriyo, 65.14 Deng, Yilun, 136.3, 122.15, 126.30 Gajalakshmi, 130.23 177.23 Deaglio, Silvia, 52.2 136.14, 136.15, Diamond, Betty, 133.17 Dalal, Bhavik, 177.11 Davies, Joanna, 182.24 Dean, Melinda, 58.16, 195.17 Diamond, Michael, Dale, Tim, 130.30 Davis, Beckley, 64.12 182.69, 187.12 Deng, Zhongbin, 192.7 121.13, 177.23 Dalgard, Clifton, 184.5 Davis, Carla, 55.21 Deane, Jonathan, 178.1 Deng, Zihou, 190.16 Diana, Julien, 177.22 Dallari, Simone, 191.9 Davis, Eric, 135.14 DeBenedetto, Matthew, Denis, Gerald, 182.87 DiAntonio, Aaron, 64.1 Dal-Pizzol, Felipe, 63.6, Davis, Ian, 119.4 135.9 Denlinger, Chadrick, Dias, Cinthia, 120.15 120.11 Davis, Jazmyne, 129.17 Debes, Gudrun, 67.17, 187.23 Dias, Joana, 72.6 Dambaeva, Svetlana, Davis, Michael, 63.12 73.14, 129.5 Dennis, Vida, 196.10 Diaz, Alain, 121.8, 179.4 129.10 Davis, Rachel, 194.6 Dechant, Cosette, Dent, Alexander, Diaz, Darren, 198.1 ı Dambrauskas, Davis, Shamara, 63.2 138.5, 186.15 119.15, 121.1, 190.28 D´az, Glorianne, 123.5 Nicholas, 72.9 Davis, Tessa, 195.24 Decker, Donna, 67.22, Denton, Stephen, Diaz, Sandra, 130.5 Damjanovska, Sofi, Davis, William, 133.16 119.25 190.52, 190.53, DiCaudo, David, 177.32 120.32 Dawes, Maisie, 187.13 Degli-Esposti, Mariapia, 190.72, 190.73 Dickerson, Sam, 117.11 Damle, Rohini, 131.16 Dawson, Kenneth, 69.38 DePierri, Kelley, 138.11 Dickey, Burton, 66.3 Dang, Jason, 185.1 196.23 Degrandi, Daniel, Depinet, Mollye, 131.6, Dickey, Laura, 115.10 Dang, Ton, 133.7 Day, Cheryl, 190.39 126.6, 126.18, 127.8, 131.24, 131.25, Dickson,Russell,197.10 Dang, Van Duc, 129.5 D’Cruz, Akshay, 59.4 190.87 131.28 Didier, Elizabeth, Dangl, Jeffery, 64.1 D’Cruz, Louise, 122.3, DeGregori, James, 65.8 Derambure, Celine,´ 126.23 Dangui, Tanushree, 128.3, 128.11 Deguchi, Tsuneo, 50.10 179.6 Diehl, Alexander, 130.26 75.8 De Armas, Lesley, 72.11 Dehnadi, Abbas, 69.8 DeRiso, Elizabeth, Diehl, Sean, 76.12 Danhorn, Thomas, 67.9 De Ciantis, Christopher, Deiters, Alexander, 184.1 Dienz, Oliver, 53.21, Daniels, Brian, 75.15 192.21 71.18 deRoos, Paul, 53.9 65.13 Danos, Abigail, 132.12 de Costa, Luciana, Dekker, Joseph, 70.21 Dervieux, Thierry, 182.8 Diep, Anh, 190.74 Dar, Sajad, 135.30 190.31 DeKrey, Gregory, Desai, Nidhi, 135.28 Dieterle,Michael,190.69 Darby, Amanda, 131.12 de Figueiredo, Paul, 67.19, 188.17 Desai, Pritesh, 177.23 Difilippantonio, Simone, Dargitz, Carl, 130.33 190.31 DeKuiper, Justin, 117.21 Deschene, Karine, 190.1 Darko, Samuel, 189.7 de Jesus, Tristan, Delfino, Teresita, 134.18 73.13 Dikshit, Neha, 63.13 Darley-Usmar, Victor, 116.15 Delgi-Esposti, Mariapia Deshmukh, Hitesh, Dill, Courtney, 52.7, 126.39 de Jesus1, Adriana, A., S78 62.15 52.8, 181.14, 181.17, Darnell, Eli, 119.25 63.4 Delgoffe, Greg, M., Deshmukh, Sachin, 194.36 Darou, Shannon, 131.14 de Jong, Petrus, 117.25 S200, 122.3 63.14, 126.36 Dillman, Adler, 190.15 Darrah, Patricia, 139.3 de Juan, Alba, 117.3 D’Elios, Mario Milco, Deshmukh, Umesh, Dimasi, Tiana, 52.1 Darrow, Morgan, de Kanter, Anne-Floor, 129.12 178.15, 180.16 Dimou, Anastasios, 126.27 177.5 Delker, Don, 120.31 Deshpande, Ani, 194.41 187.23 Darwish, Martine, 132.4 de la Morena, M. Della Vedova, Chris, Desjardins, Michel, DiNardo, Andrew, Das Sarma, Jayasri, Teresa, 120.9 61.5 177.27 62.21, 194.17 126.9, 126.17, 185.3 de la Morena, Maria, Dell’Orso, Stefania, Devalaraja, Samir, 135.7 Dinarello, Charles, Das, Arpita, 122.2 182.32 181.27 DeVallance, Evan, 59.7 52.17, 65.8

140 AUTHOR/SPEAKER INDEX

Dine, Kimberly, 126.17 Donthireddy, Duan, Lihua, 182.29 Eaves, Allen, 58.3, Eisenmesser, Elan, Ding, Chuanlin, 194.14 Laxminarasimha, Duan, Yuanyuan, 60.10 71.3, 130.14, 130.18 65.8 Ding, Sheng-Li, 190.31 58.18 Duarte, Manuel, 115.6 Ebrahimi-Nik, Hakimeh, Eisinger, Dominic, DiPaolo, Richard, 137.7 Doody, Gina, 123.7, Dubinin, Alexandra, 70.13 130.22 DiPasquale, Betsy, 123.23 129.1 Ebsworth, Karen, 133.7 Eitzinger, Simon, 140.12 181.9 Dooms, Hans, 125.2 Dubois, Courtney, Echeverry, Mariana, Eken, Ahmet, 193.12 DiPatrizio, Nicholas, Dopkins, Nicholas, 130.13, 131.21 126.26 Eko, Francis, 126.32 190.15 115.24, 192.12 Duchi, Roberto, 70.14 Ecker, Jeffrey, 139.23 Ekoff, Helena, 130.35 DiRusso, Concetta, Dori, Yoav, 51.5, 189.7 Duck, Lennard, 191.7 Edelblute, Chelsea, Ekong, Udeme, 182.39 58.18 Dorjbal, Batsukh, 184.5 Ducrot, Charles, 177.27 136.2 El Andaloussi, Divangahi, Maziar, Doron, Itai, 191.3 Dudakov, Jarrod, 53.9 Edelson, Brian, 60.2 Abdeljabar, 190.38, 190.27, S154 Dorshkind, Kenneth, Duduskar, Shivalee, Edemobi, Stefan, 190.51, 190.63 Divekar, Anagha, 118.10 63.14, 126.36 121.14, 122.12, el Baghdady, Sarah, 52.20, 64.15 Dorta-Estremera, Duerschmied, Daniel, 182.75 57.6, 67.3 Diwu, Zhenjun, 130.28 Stephanie, 70.15 126.25 Eden, Kristin, 67.7, Elahi, Shokrollah, 57.5, Dixit, Saurabh, 196.10 Dorward, Dave, 57.17, Duhen, Thomas, 51.7 129.11, 182.30, 76.18, 120.2 Dixit, Vishwa, 62.7 128.6 Dukes, April, 61.9 194.31 Elango, Madhivanan, Dixon, Beverly, 117.20 Dose, Christian, Dunai, Cordelia, 56.17, Edgcomb, Stephen, 196.4 Dixon, Karen, 137.15 130.27, 130.31, 69.36, 126.27, 197.12 71.19 Elangovan, Ramya, Dlugolenski, Daniel, 134.15, 194.26 Dunbar, Paul, 74.1 Edlich, Frank, 126.25 196.30 130.19 Doty, Rosalinda, 115.15 Duncan, Heather, 132.8 Edquiban, Marianne, Elia, Jeanne, 184.6, Doan, Ton, 119.3 Dou, Aihua, 194.16 Duncan, Skyla, 196.10 61.21 194.38 Dobin, Alexander, Doucet, Michele, 183.21 Dunn, Patrick, 130.26 Edwards, Bathai, 190.1 Eliason, Amber, 68.11 185.1 Douek, Daniel, 189.7, Dunsmore, Garett, Edwards, James, 137.9 Elkon, Keith, 182.26 Dobosh, Brian, 183.15 197.3 120.2 Edwards, Michael, Ella, Bhagyaraj, 196.2 Dobzanki, Alex, 75.16 Douglas, Gavin, 192.4 Dupont, Maeva, 190.79 50.13 Eller, Silvia, 190.62 Docampo, Melissa, Douglass, Jacqueline, Duquette, Pierre, Edwards, Robert, 190.6 Ellington, Andrew, 71.15 69.34 177.18 182.38 Edwards, Sarah, 130.19 Elliot, Michael, 74.12 Doebel, Thomas, 58.12 Doumbo, Safiatou, Durai, Vivek, 177.23, Edwards, W., 192.13 Elliott, Jennifer, 197.21 Doffinger, Rainer, 52.14 126.7 177.33 Effern, Maike, 138.2 Elliott, Nathan, 131.26 Dogra, Pranay, 60.5, Doumtabe, Didier, 126.7 Durazo-Acuna, Alberto, Egan, Ashley, 190.20 Ellis, Amy, 177.29, 129.8 Dowdell, K., 76.16 70.17 Egan, Josephine, 190.36 Doherty, Edward, Dowling, John, 60.18 Durbin, Anna, 76.12 182.35 Ellis, Jason, 186.13 180.13 Downs, Isaac, 64.20 Durbin, Drew, 136.16 Egawa, Takeshi, 53.23 Elly, Chris, 57.6 Dolina, Joseph, 71.14 Dozmorov, Igor, 120.9, Durdik, Jeannine, Egedal, Johanne, Elmore, Jessica, 55.20 Doloff, Joshua, 126.37 182.32 126.10 66.12, 197.2 Elong Ngono, Annie, Domenico, Joanne, Dragon, Julie, 53.21 Duroux-Richard, Egelston, Colt, 138.17 140.15 52.17 Drake, James, 177.20 Isabelle, 50.12 Egelston, Colt, 138.21 El-Rayes, Bassel, 70.8 Dominguez, George, Drake, Li, 119.27 Durre, Kainath, 119.22 Eggert, Joel, 66.17 Elsaesser, Heidi, 197.10 137.4 Dranka, Brian, 56.16 Durrett, Russell, 71.15 Egilmez, Nejat K., 71.6 Elsawa, Sherine, 64.14, Dominguez, Donye, Draper, Sarah, 196.27 Dutta, Avijit, 57.16, 74.4 Ego, Kaori, 59.2, 194.35 70.12, 134.7, 195.21 Dravid, Piyush, 196.13 Dutta, Bhaskar, 59.6 187.21 Elsayed, Nourhan, Dominguini, Diogo, Drerup, Justin, 136.3, Dutta, Noton, 125.19 Eguchi, Satoru, 118.2 50.16 63.6, 120.11 136.15 Duval, Ana¨ıs, 119.29 Egwuagu, Charles, El-Sherbiny, Yasser, Domrose,¨ Andreas, Drescher, Florian, Duvvuri, Bhargavi, 123.10, 180.6 63.3 190.62 138.10 63.12 Ehinger, Erik, 182.1 Elshikha, Ahmed, Donadi, Eduardo, Drews, Caitlyn, 75.21 Dvorina, Nina, 69.14 Ehtesham, Nasreen 132.12 136.10 Dring, Eddie, 123.18 Dworsky, Meyer, 131.28 Zafar, 120.7 Elson, Charles, 191.7 Dong, Chen, 69.10, Driver, John, 50.9 Dwyer, Gaelen, 69.35 Eibschutz, Liesl, 68.19 Eltahla, Auda, 74.12 128.2 Driver, John P., S32 Dwyer, Jennifer, 115.8 Eich, Christina, 181.4 Eltanbouly, Mohamed, Dong, Haidong, 60.2, Dropulic, Lesia, 76.16 Dzutsev, Amiran, Eickhoff, Christopher, 182.37 195.1 Drourr, Joshua, 192.13 191.12 190.10 Emele, Felix, 190.68 Dong, Han, 63.15 Druey, Kirk, 182.17 Eidenschenk, Celine, Emmons, Tiffany, Dong, Huiping, 194.28 Druker, Brian, 195.10 133.3 137.13 Dong, Lauren, 134.13 Drummond, Daryl, E Eill, Elizabeth, 58.19 Emschermann, Dong, Panpan, 181.20 195.11 Eamsobhana, Eischen, Christine, Frederic, 126.25 Dong, Zack, 182.83 Dryden, Gerald, 192.4 Praphathip, 190.59 181.15 Ende, Zachary, 139.17 Donham, Cristine, Du Bruyn, Elsa, 190.78 Easlick, Juliet, 69.27 Eisenhower, Mary, Endo, Yukinori, 64.7 118.16 Du, Qian, 124.1 Eastham-Anderson, 131.6, 131.25, 131.28 Endsley, Eric, 130.30 Donmez Altuntas, Du, Qiumei, 182.32 Jeffrey, 132.4 Eisenlohr, Laurence, Endsley, Janice, Hamiyet, 193.12 Du, Xiaoping, 187.4 Eaton, Kathryn, 191.1 188.11 127.17, 139.2, 177.17

141 AUTHOR/SPEAKER INDEX

Eng, Hock-Liew, 127.5 Evaristo, Cesar, Fang, XiangMing, 122.4 Fernandes Gabriel, Fisher, Devin, 196.14 Engel, Isaac, 65.3 130.27, 130.31, Fang, Zhou, 126.12 Filipe, 63.6 Fisher, Eva, 126.31 Engel, Jessica, 186.1 134.15, 194.26 Farah, Shady, 126.37 Fernandez, David, 50.8 Fites, J. Scott, 70.19, Engelhard, Victor H., Evavold, Brian, 76.13, Farahi, Farzam, 131.19 Fernandez, Maria, 190.17 S17 115.18, 180.7, Farber, Donna, 60.5, 195.6 Fitzgerald, Jonathan, Engelhardt, Karin, 190.77, S98 67.21, 122.13, 129.8, Fernandez-Cabezudo, 136.20 52.14 Everett, Christine, 133.3 S25 Maria, 50.16, 66.9 Flaherty, Kevin, 182.3 Engelman, Alan, 197.21 Evgy, Yentl, 187.32 Farber, Joshua, 117.23, Ferrante, Andrea, Flaherty, Stephanie, Engkilde-Pedersen, Ewen, Catherine, 183.21 131.39 115.19 Sanne, 182.69 130.14 Fares-Frederickson, Ferrante, Antonio, Flajnik, Martin, 73.3 Enriquez, Josue, 69.3, Exstrom, Drake, 185.15 Nancy, 66.21 126.34 Flavell, Richard, 129.9 69.22 Eze, Emmanuel, 122.9 Farhat, Sepideh, 129.1 Ferrarese, Roberto, Flaveny, Colin, 137.7 Enyindah-Asonye, Farnsworth, Aaron, 178.8 Fleming, Sherry, 126.21 Gospel, 72.2, 72.5, 139.13 Ferraro, Anne Lise, Flemington, Cathy, 75.20, 140.9, 197.1 F Farooq, Hamza, 194.41 126.16 192.1 Eom, John, 177.4 Faatoese, Adam, 61.20 Farr, George, 186.8 Ferreira, Viviana, S100 Fletcher, Paige, 117.6 Epstein, Alan, 122.10 Fa’atoese, Adam, 61.11 Farrand, Kathryn, Ferrill, Rachel, 178.18 Flood, Blake, 135.6 Erb, Carla, 131.30 Fabry, Zsuzsanna, 196.27 Ferrini, Maria, 119.28 Flores, Jose, 66.3 Erdem, Serife, 193.12 51.8, 117.13, 121.10, Farris, Breanne, 115.12 Ferris, Martin, 197.9 Flores-Solis, David, Erdos, Geza, 133.6 190.40 Farris, Eric, 139.14 Ferris, Robert, 138.15, 177.31 Erlebacher, Adrian, Facca, Valerie, 130.18 Farzam-kia, Negar, 195.9 Florez-Vargas, Oscar, 129.3 Facciotti, Federica, 182.66 Ferris, Stephen, 177.33 182.48 Ertl, Linda, 133.7 178.8 Fast, Loren, 136.26 Ferry, Gabrielle, 134.17 Flower, Robert, 58.16, Escano, Jerome, 75.4 Faddy, Helen, 182.69 Fatehchand, Kavin, Feser, Colby, 69.10 182.69 Eschbach, Jenna, Fagarasan, Sidonia, 59.12 Fessler, Michael, 51.14, Floyd, Alexandria, 126.3 197.21 56.2 Fathi, Mohsen, 134.2 187.20 Flynn, JoAnne, 139.3, Esguerra-Lallen, Fahlberg, Marissa, Fatkhullina, Aliia, 118.2, Fest, Scarlett, 55.19 177.29, 182.86, Arlanna, 182.69 126.23 191.12 Feuer, Ralph, 66.20 190.3, 190.33, 190.41 Eshleman, Emily, 64.19 Fahmy, Ahmed, 177.27 Faupel, Ciara, 195.25 Feuerecker, Matthias, Flynn, Patrick, 187.29 Eskiocak, Ugur, 194.2 Fain, Cori, 56.20, 190.19 Faust, Ashley, 116.14 182.15 Flynn, Ryan, 69.42 Espat, N., 71.1 Fairchild, Robert, 55.8, Fazal, Nadeem, 61.6, Feyznezhad, Roya, Foda, Bardees, 115.20, Espat, N. Joseph, 130.1 55.9, 69.14, 69.16 61.12, 61.21, 182.5 197.17 116.9 Espinosa, Diego, Fairgrieve, Marian, Fearns, Rachel, 198.14 Ficht, Thomas, 190.31 Foerster-Marniok, 196.24 63.12 Fecci, Peter, 138.5, Fields, Gregg, 56.3, Anna, 130.31 Espinosa, Gabriel, 73.19 Falach, Reut, 187.32 186.15 180.8 Fogle, Jonathan, 76.11 Espinosa, Joaquin, Falcone, Marika, 178.8 Fecek, Ronald, 194.27 Fields, Travis, 182.89 Folkert, Ian, 135.7 52.1, 181.10 Falik, Nouraiz, 134.13 Federico, Sara, 134.14 Fiering, Steven, 136.7 Fomenko, Ruslan, 55.18 Espinosa-Diez, Falk, Ben, 52.15 Fedorova, Olga, 194.28 Fiers, William, 191.3 Fong, Lawrence, 129.8 Cristina, 194.39 Falo, Louis, 54.5, 133.6 Feeney, Ann, 72.8 Figueroa Pensado, Fonseca, Rephany, Esqueda, Marisol, Falta, Michael, 182.57 Feeny, Margaret E., Monserrat, 132.11 140.20 190.25 Fan, Daping, 59.9, S34 Files, Megan, 139.2 Fontanari, Caroline, Esquivel, Daniel, 70.11, 194.11 Fehniger, Todd, 76.9 Filler, Scott, 190.4 125.10 196.21 Fan, Guang, 69.17, Fehr, Anthony, 198.4 Finck, Brian, 118.17 Fontenot, Andrew, Essman, W., 179.5 120.12 Fehr, Thomas, 69.8 Fine, Noah, S101 182.57, 182.68 Essuman, Kow, 64.1 Fan, Hongkuang, 181.3 Felber, Barbara, 72.4 Fink, Pamela J., S24, Fontenot, Jason, 133.2 Estevez, Alberto, 131.19 Fan, Jie, 62.9, 70.12, Feldman, Tatyana, SAP1 Fontes, Ghislaine, Estrada, Jose, 69.27 122.4, 134.7, 195.21 76.16 Fink, Susan, 63.12 190.27 Estrada-Garc´ıa, Iris, Fan, Ran, 69.29 Felgner, Jiin, 131.32 Finley, Stacey, 64.27 Foo, Juat Chin, 122.3 190.86 Fan, Yiping, 134.14 Felices, Martin, 136.22 Finn, Caroline, 66.13, Ford, David, 137.9 Estrada-Parra, Sergio, Fan, Zhichao, 182.1 Fellon, Corey, 131.32 122.8 Foreman, Taylor, 190.78 190.86 Fan, Zusen, S106 Felton, Jamie, 115.14 Finn, M.G., 60.12 Forero, Andres, 195.7 Estupinian, Ricardo, Fancher, Karen, 130.10 Feng, Feng, 198.14 Finn, Olivera, 71.18, Forkel, Marianne, 136.6 Fanchiang, Shaohsuan, Feng, Xuehuan, 190.31 135.5, 136.17 187.10 Evanko, Stephen, 57.10 Feng, Yongqiang, Finnegan, Ryan, 54.12 Formosa, Luke, 60.7 180.11 Fang, Difeng, 124.13, 131.34 Finnerty, Celeste, Forno, Erick, 66.11 Evans, Katrina, 135.4 188.10 Feng, Zongdi, 197.16 126.13, 187.25 Forsberg, Camilla, Evans, Leonard, 180.2 Fang, Michael, 140.17 Ferguson, Annabel, Finney, Helene, 123.23 118.1, 118.13 Evans, Scott, 66.3 Fang, Min, 74.14 182.31 Firek, Brian, 192.10 Forsberg, Matthew, Evans, Stephanie, Fang, Qian, 178.3, Ferhat, Maroua, 185.10 Firestein, Gary, 57.4 69.39, 116.9 182.86 192.5 Feris, Edmond, 182.79 Fischer, Nicholas, 71.5, Forsthuber, Thomas, Evans, Tyler, 67.16 Fang, Xiang, 68.3 Ferm, Jonathan, 126.21 130.21 123.4, 180.3, 193.8

142 AUTHOR/SPEAKER INDEX

Fortune, Sarah, 190.33, Fu, Mingui, 59.9 Galdiero, Maria Gardner, Edward, 72.12 Geissmann, Frederic, 190.41 Fu, Shuyu, 137.4 Rosaria, 126.16 Gardner, James, 129.3 118.12 Foss, Catherine, 177.14 Fu, Wenxian, 128.10, Gale, Michael, 63.12, Gardner, Jameson, 75.5 Geller, Melissa, 136.22, Foster, Greg, 51.13 178.16, 180.14 74.3 Gardner, Mariana, 66.16 194.6 Fournier, Pierrick, Fu, Xiangdong, 125.20 Galkina, Elena, 121.14, Gareau, Melanie, 66.16 Gelman, Andrew, 69.9, 138.10 Fu, Yang-Xin, 56.21 122.12, 182.75 Garfa, Meriem, 177.22 69.21 Fowell, Deborah, 51.18, Fu, Yongyao, 119.13, Galle, Lauriane, 122.10 Garg, Ankita, 62.13 Gelman, Benjamin, S40 128.5, 128.14, 182.41 Gallego, Juan, 121.6 Garg, Priyanka, 194.10 127.17 Fox, Elizabeth, 130.9 Fuchs, Anja, 118.3 Galle-Treger, Lauriane, Gargaro, Marco, 177.23 Gemmill, Robert, 187.23 Fox, James, 52.13 Fuchs, Bryce, 180.11 51.12 Gariepy, Jean, 71.5 Genardi, Samantha, Fragoso-Soriano, Fugmann, Sebastian, Galli, Cesare, 70.14 Garijo, Olivia, 53.4 190.5 Rogelio, 51.3 73.22 Galli, Stephen, 126.2 Garofalo, Roberto P, Generoso, Jaqueline, França Lodetti, Bruna, Fujii, Chika, 53.23 Gallin, John, 182.17 198.9 63.6, 120.11 63.6 Fujimura, Kei, 191.17 Gallina, Maria, 130.23 Garrett-Thomson, Genetu, Maza, 190.56 Franceschetti, Fujisawa, Takao, Gallucci, Stefania, Sarah, 131.8, 182.56 Geng, Jie, 60.3 Massimo, 131.38 130.35 180.17 Gartland, Julie, 75.10 Gennaro, Maria, 125.19 Franco, Alessandra, Fujita, Mayumi, 52.17 Galvan-Hern´ andez,´ Garton, Joshua, 118.7, Gentile, Marilena, 57.4 Fujiwara, Hideaki, 56.6 Arturo, 51.3 118.8 190.27 Franco, Rafael, 118.18 Fukui, Elle, 191.17 Gama, Lucio, 72.6 Garzon, Hernan, 178.4 George, Anna, 192.6 Frank, Allayna, 131.14 Fukui, Yoshinori, 55.11, Gamache, Awndre, 76.5 Gascoigne, Nicholas, George, Evalyn, 130.11 Franke, Yvonne, 132.4 116.7, 185.12 Gamal, Wael, 194.42 189.6 George, Junu, 50.16 Franklin, Michael, 67.1 Fukunishi, Shinya, Ganchua, Sharie Gashev, Anatoliy, 54.10 Georgiev, Ivelin, 72.7, Franks, Caroline, 71.7 120.14, 195.14 Keanne, 190.33 Gasheva, Olga, 54.10 138.7 Frantz, Fabiani, 125.10 Fukuoka, Yoshihiro, Gandhi, Monika, 183.9 Gasser, Roman, 190.79 Georgiou, George, Frasca, Daniela, 121.8, 54.6 Ganesan, Latha Gattinoni, Luca, 140.2 71.15, 137.11 179.4 Fukutani, Kiyoshi, Prabha, 190.66 Gatzka, Martina, 128.17 Gerberick, Abigail, Fraser, Iain, 59.6 190.22 Gangadharan, Gaudet, Jeff, 130.7 190.66 Fraser, John, 182.69 Fuller, Roberta, 72.8 Achintyan, 138.18 Gaudette, Brian, 188.3 Geretti, Elena, 136.20 Fraser, Kathryn, 66.21 Fulton, Ross, 195.11 Gangappa, Gaudino, Federica, Gerhart, Ryan, 126.38 Frazier, Victoria, 136.9 Fung, Helen, 189.8 Shivaprakash, 139.17 52.2 Gerlic, Motti, 59.4 Freeborn, Jasmin, 193.2 Funk, Christopher, Gangur, Venugopal, Gaudino, Stephen, Germain, Ronald, 59.2, Freeborn, Robert, 55.3 71.17 55.5, 55.6 181.7, 181.11 59.6 Freedman, Samantha, Furlonger, Caren, 71.11 Ganusov, Vitaly, 122.1, Gaulton, Kyle, 185.1 Gerner, Michael, 51.11, 178.13, 178.14 Furr, Kathryn, 69.3, 122.14 Gautam, Shalini, 59.12 58.2 Freeley, Simon, 56.10 69.22 Gao, Fei, 122.6, 197.22 Gauthier, Marc, 119.1 Gershwin, M Eric, 179.3 Freeman, Gordon, Furusawa, Emi, 55.10 Gao, George, 197.26 Gavile, Catherine Ann, Gert, Philipp, 194.26 195.31 Fuss, Ivan, 120.26 Gao, Haoran, 55.5, 55.6 180.7 Gertz, E. Michael, Freilino-Glunt, Maria, Gao, Hongjuan, 119.21 Gavin, Amanda, 178.6, 186.10 187.23 Gao, Iris, 191.3 187.6 Gery, Igal, 193.7 Frelinger, John, S30 G Gao, Min, 179.5 Gavin, Marc, 207.1 Getahun, Andrew, Frentzen, Angela, Gable, Matthew, Gao, Tess, 194.10 Gavre, Adrian, 182.58 121.14, 182.68 70.16, 134.1 115.21, 128.16 Gao, Xia, 194.20 Gavrilin, Mikhail, 62.20 Geurts, Aron, 116.9 Frey, Avery, 184.6 Gabriel, Erin, 182.88 Gao, Xueli, 190.9 Gavrilova, Oksana, Gharib, Karim, 195.3 Frias, Adolfo, 128.3, Gabriel, Sarah, 140.16 Gao, Yuan, 69.44 116.13 Ghassemi, Saba, 128.11 Gabrilovich, Dmitry, Gao, Yuanyuan, 128.7 Gawali, Vaibhavkumar, 131.22 Friberg, Danielle, 187.10 58.18, 137.4, 137.12, Garancher, Alexandra, 195.34 Ghebrendrias, Natsinet, Friedenberg, Steven, 194.2 194.41 Gawde, Saurabh, 68.12 66.2 73.9 Gabrusiewicz, Konrad, Garc´ıa Paredes, V´ıctor Gay, Cindy, 197.14 Ghersi, Dario, 74.7 Friedman, David, 135.8 135.14 Gabriel, 190.86 Gazaniga, Nathalia, Ghilardi, Nico, 133.3 Friedmann-Morvinski, Gadermaier, Gabriele, Garcia, Denisse, 126.31 181.27 Ghimire, Laxman, 62.5, Dinorah, 135.23 70.23 Garcia, Jose, 182.24 Ge, Dongyu, 55.14 62.17, 126.24 Friedrich, Kathleen, Gadina, Massimo, Garcia, K., 52.15 Ge, Linhu, 50.17 Ghofrani, Joshua, 76.4 180.9, 182.51 181.27 Garcia, Myrna, 136.15 Ge, Qing, 53.7, 57.14 Ghoneim, Hazem, Frietze, Seth, 179.15, Gadjeva, Mihaela, Garcia, Niko, 182.22 Geary, Clair, 76.9 134.14 179.16 127.22 Garc´ıa-Contreras, Gebhardt, Thomas, Ghonim, Mohamed, Fritz, Daniel, 64.2 Gagnon, Etienne, 184.7 Rodolfo, 118.18 138.2, 189.1 119.9 Frost, Elizabeth, 187.7 Gajardo, Gonzalo, 73.19 Garc´ıa-Sastre, Adolfo, Geddes-McAlister, Ghosh, Debopam, Fryer, John, 126.5 Gajnayaka, Niranjala, 127.18, 136.4, S199 Jennifer, 127.22 188.11 Fu, Chuntang, 51.1 64.23 Garcia-Vilas Garcia, Geels, Shannon, 57.6 Ghosh, Sarbani, 118.3 Fu, Guo, 189.6 Gal, Yoav, 187.32 Javier, 195.3 Geha, Raif, S39 Giacobazzi, Mario, Fu, Min, 70.3 Galbraith, Matthew, 52.1 Gardina, Paul, 190.78 Geiger, Tamar, 134.6 196.30

143 AUTHOR/SPEAKER INDEX

Giangarra, Valeria, Glimcher, Laurie, 63.15 Gong, Huanle, 69.24, Gracias, Donald, Grimm, Sara, 119.23 194.29 Globus, Ruth, 182.13 69.25 119.17, 119.20 Grimmett, Zachary, Giannone, Valeria, Glover, Sarah, 192.13 Gonzalez Avalos, Graham, Andrea, 131.3 197.2 196.23 Gmyrek, Grzegorz, Edahi, 123.15, 134.3 Graham, Jessica, 57.8 Grisham, Matthew, Gibbs, Jmes, 139.20 75.19, 180.16 Gonzalez, Isaac, 52.18 Graham, Natalie, 53.22 69.3, 69.22 Gibson, David, 189.14 Godarova, Alzbeta, Gonzalez,´ John, 126.26 Graham, Timothy E., Groft, Sarah, 64.24 Gibson, Heather, 195.30 181.26 Gonzalez, Michael, 185.10 Grousd, Jennifer, Gideon, Hannah, 190.41 Goddery, Emma, 56.20, 121.17 Granados, Julio, 120.5, 66.11, 190.49 Giese, Rachel, 136.23 126.5 Gonzalez, Rodrigo, S40 182.79 Grove, Lisa, 58.4, 127.7 Gigley, Jason, 190.52, Godfrey, Dale, 196.27 Gonzalez-de-Peredo, Granrath, Ross, 52.1 Gruenheid, Samantha, 190.53, 190.72, Godin, Steven, 72.13 Anne, 119.29 Grant, Nicole, 177.29 177.27 190.73, S24 Godwin, Matthew, Gonzalez-Martin, Alicia, Gras, Stephanie, 74.12 Grund, Ethan, 180.1 Gigoux, Mathieu, 137.3 55.15 72.8 Grassi, Alessia, 129.12 Grzelak, Ludivine, Gijon,´ Miguel, 137.11 Goepfert, Paul, 76.4 Gonzalez-Montaner,´ Gratz, Iris, 51.7 74.12 Gil Pages, Diana, 68.18 Goetschius, Daniel, Pablo, 190.79 Gravel, Caroline, 139.13 Gu, YuanTong, 58.16 Gil, Anna, 74.7 197.15 Gonzalez-Telona, Ana Gray, Edward, 69.27 Gu, Vivian, 61.19 Gil, Diana, 195.24 Goguet, Emilie, 182.21 Daniela, 196.26 Gray, Jerilyn, 62.15 Gu, Wei, 137.11 Gilbert, Kathleen, 50.7 Gohel, Dhruv, 54.5 Good, Misty, 192.10 Grayson, Mitchell, Gu, Xuemei, 192.7 Gilchrist, Ashley, 74.2 Goiberg, Polina, 130.36 Good-Jacobson, Kim, 55.13 Gu, Yan-Ni, 183.6 Giles, Daniel, 67.8, Gois, Bruna, 120.15 60.7 Greaves, Sarah, 182.57 Guan, Hongbing, 50.17 191.11 Gola, Anita, 59.2 Goodwill, Patrick, 130.7 Green, Douglas, 56.10 Guan, Monica, 134.7 Gilfillan, Susan, 181.28 Goldbach-Mansky, Goonawardhana, Suraj, Green, Judy, 191.18 Guan, Yukun, 128.7 Gilkeson, Gary, 181.3 Raphaela, 63.4, 140.11 Green, Kathy, 58.1 Guay, Frederic, 73.13 Gill, Avinash, 131.19 120.26 Goonetilleke, Nilu, Green, Michael, 137.11 Gubbels Bupp, Gill, Ronald, 68.5 Goldberg, Ben, 72.9 197.14 Green, Patrick, 75.16 Melanie, 50.11, Gillanders, William, Goldberg, Emily, 62.7 Gopal, Radha, 66.11 Green, Richard, 74.3 189.14 177.23 Goldblatt, David, 66.3 Gopalakrishna, Greenbaum, Jason, Gudkov, Andrei, 182.70 Gillaspy, Allison, 196.19 Golden, Jackelyn, Kathyayini, 192.10 65.3, 70.16, 120.20, Guenther, Garret, Gillespie, Alexandria, 140.17 Gopinath, Smita, S101 131.18, 182.27 130.17 73.23 Golding, Amit, 132.15, Goplen, Nick, 129.18 Greene, Kellee, 182.70 Guerau-De-Arellano, Gillespie, Alyssa, 76.5 186.4 Gordon, Brandon, Greene, Trever, 187.28 Mireia, 119.6, 186.9 Gilliland, Frank, 122.10 Golding, Hana, 64.7, 190.51 Greene, Warner, 66.12, Guerau-De-Arellano, Gillis-Buck, Eva, 129.3 64.8 Gordon, John, 182.16 197.2 Miriea, 182.60 Gilpin, Trey, 51.8 Goldman, Naomi, Gordon, Nancy, 135.13 Greenfield, Edward, Guerra-Gomes, Isabel, Gimenez, Fernada, 138.11 Gordon, Sarah, 191.13 195.31 120.15, 140.20 73.20 Goldrath, Ananda W, Gordy, Laura, 60.6 Green-Johnson, Julia, Guerra-Maupome, Gingeras, Thomas, 60.14, 125.6, 138.6, Gorelick, Robert, 191.18 Mariana, 73.16, 73.18 185.1 186.2, 188.8, 189.12, 182.88 Greenman, Dina, 50.8 Guerrerio, Anthony, Gingerich, Aaron, S142 Goronzy, Jorg, 71.15 Greenplate, Allison, 67.15 127.21 Goleniewska, Kasia, Gorry, Michael, 119.1 138.7 Guerrerio, Pamela, Ginsburg, David, 56.6 181.15 Goshu, Bruktawit, 72.14 Greenwell, Cynthia, 182.52 Ginwala, Rashida, Golinski, Marie-Laure, Gosselin, Edmund, 182.55 Guerrero-Plata, Maria, 75.16 179.6 139.6 Greenwood, Dalton, 198.13 Gioia, Louis, 120.33 Gollihar, Jimmy, 71.15 Gothe, Florian, 52.14 137.10 Guerrini, Matteo, 56.2 Girard, Jean-Philippe, Gollnick, Sandra, 194.9 Goto, Motohito, 129.15, Greer, Michael, 192.2 Guevera, Elizabeth, 119.29 Golonka, Rachel, 59.3, 131.31 Gregorczyk, Izabela, 135.24 Giri, Shailendra, 127.19, 192.9 Goto, Ronald, 73.8, 68.2 Gugiu, Gabriel, 177.6 135.30, 183.12 Gomer, Richard, 126.11 177.6 Greilach, Scott, 193.10 Guglielmo, Michael, Giridharan, Vijayasree, Gomes, Ciro, 52.23 Gottlieb, Peter, 182.72 Greiner, Dale, 126.37 182.50 120.11 Gomez, Gabriel, 190.31 Gouin, Sebastien,´ Grieco, Joe, 178.11 Guha, Prajna, 71.1, Giver, Cynthia R, 69.41 Gomez, Gregorio, 54.7 192.3 Griesenauer, Brad, 69.6 130.1 Gizzi, Katiuscia, 52.2 Gomez-Donart, Gould, Timothy, 71.15 Griffen, Tiara, 52.7, Guha, Rajan, 126.7 Glant, Tibor, 133.4 Andrea, 131.7 Goulmamine, Syreen, 52.8, 181.14, 181.17, Gui, Michael, 70.19 Glanz, Anna, 75.10 Gomez-Gutierrez, 189.14 194.36 Gui, Xien, 194.13 Glass, Christopher, Jorge G., 71.6 Goverman, Joan, S201 Griffin, Diane, 198.8 Guidos, Cynthia, 59.2, 187.19, 187.21 Gomez-Mart´ ´ın, Diana, Gowdy, Kymberly, Griffith, Ann, 65.15, 197.10 Glass, Deborah, 57.17 179.7, 179.8 51.14, 187.20 65.16, 115.25 Guilford, Parry, 130.37, Glassy, Mark, 194.22 Gomez-Olarte,´ Sergio, Grabow, Stephanie, Grifoni, Alba, 76.12, 130.38 Glenn, Lindsey, 122.12 126.26 195.11 140.11, 140.14 Guilloton, Pauline, 66.2 Glennon, Moriah, Gong, Ai-Yu, 190.12, Grabowski, Gregory, Grigorova, Irina, Gulati, Aakanksha, 182.22 190.83 181.9 121.15, 125.14 127.14

144 AUTHOR/SPEAKER INDEX

Guldevall, Karolin, Ha, Un-Hwan, 189.13 Hamade,Hussein,129.6 Hardaway, John, 71.1, Hasham, Muneer, 131.29 Haase, Volker, 186.17 Hamamoto, Hidetoshi, 130.1 116.12 Gullicksrud, Jodi, 122.5 Habib, Chloe, 182.25 55.10 Harder, James, 178.18 Hashem, Anwar, Guma, Monica, 125.1 Hackett, Justin, 195.30 Hambleton, Sophie, Harding, Clifford, 64.24 139.10 Gumperz, Jenny, 69.2 Hackney, Joshua, 139.3 52.14 Harding, Jeffrey, 117.13 Hashimi, Marziah, 51.6 Gunasekera, Dilini, Haddad, Lisa, 192.16 Hambright, Heather, Hardman, Blair, 66.23 Hashimoto, Kahoko, 52.13 Haddad, Elie, 182.66 195.5, 195.17 Hardt, Olaf, 134.15, 177.26 Gunasekera, Hadiono, Matthew, Hamel, Yamina, 177.22 194.26 Haskins, Kathryn, 68.5, Suvanthee, 73.21 192.21 Hamerman, Jessica A., Harel, Michal, 134.6 180.2, 182.72 Gunasena, Bandu, Hafenstein, Susan, S142 Harhaj, Ed, 75.16 Hasley, Rebecca, 56.11 120.20 197.15 Hamilton, Betty K., Haribabu, Bodduluri, Hasnain, Seyed Gunn, Michael, 70.20 Hafler, David, 52.15 120.19 192.4 Ehtesham, 120.7 Guo, Fukun, 181.20 Hafler, David A., S16 Hamilton, Ray, 117.6 Haricharan, Svasti, Hassan, Intisar, 126.10 Guo, Haitao, 64.12, Hafner, Markus, 187.1, Hamilton, Thomas, 194.41 Hassan, Mojibade, 197.4 187.2 127.7 Hariff, Melanie, S153 69.41 Guo, Hui, 115.13 Hagan, Cassidy, 52.16 Hamilton, Victoria, 196.6 Hariharasubramanian, Hassan, Oluwatomi, Guo, Lei, 120.17 Hage, Adam, 64.16, Hammer, Gianna, Anjhana, 196.30 55.21 Guo, Yizhan, 69.9 127.13 126.35, 135.1 Haririparsa*, Neda, Hasselmann, Jonathan, Gupta, Aditi, 136.23 Hager, Denver, 133.13 Hammer, Richard, 120.13 193.10 Gupta, Arnab, 135.25 Hager, Gordon, 53.12 195.24 Harley, John, 197.11 Hastings, Karen, 177.32 Gupta, Arnav, 178.13 Hahm, Bumsuk, 74.10, Hammerich, Linda, Harly, Christelle, 53.1 Hattakam, Sararat, Gupta, Gaurav, 52.23, 197.5 70.9, 136.4, 136.19 Harman, Christian, 140.5, 140.15 190.21 Hahn, Bevra, 132.10 Hampel, Kenneth, 65.13 129.9 Hatton, Robin, 124.10 Gupta, Harshita, 75.17, Hai, Rong, 127.20 Hamrah, Pedram, Harms, Robert, 178.5 Haugen, Jessica, 139.1 136.3, 136.14, 136.15, Haidl, Ian, 69.45 117.15 Harper, Jourdan, 64.5 Haughian, James, 137.8, 195.5, 195.16, Haigwood, Nancy, 72.9 Han, Arnold, 195.3 Harriett, Amanda, 135.22 195.17, 195.29 Haines, Robert, 188.9, Han, Ji Won, 120.8 125.16, 139.16 Hauser, Carl, 182.43 Gupta, Rahul, 190.31 188.15 Han,Jian,131.6,131.24, Harrington, Susan, Havran, Wendy, 53.4, Gupta, Rashmi, 182.62 Haining, W. Nicholas, 131.25, 131.28 195.1 60.12, 194.1 Gupta, Rinkesh, 119.17 58.17 Han, Jichang, 138.1 Harris, Claire, S100 Hawkins, Meridith, Gupta, Shagun, 185.1 Hainzl, Heidi, 128.17 Han, Jihye, 57.6, 67.3 Harris, Curtis, 190.1 182.58 Gupta, Suman, 192.6 Hait, Sabrina, 72.2, Han, Saemi, 182.37 Harris, Deshea, 117.15 Hawn, Thomas, 66.10 Gurevich, Irina, 119.14 72.3, 72.5, 75.20 Han, Sang-Bae, 51.17, Harris, Eva, 76.12, Hawse, William, 122.3 Gurram, Rama, 128.12, Hajdu, Peter, 131.9 134.20, 187.11 196.24 Hawthorne, Jenci L., 130.12 Hajdu, Peter,´ 184.3 Han, Seung Hyun, Harrison, David, 69.26 71.6 Gurung, Prajwal, 127.3, Hajjar, Adeline, 127.12 127.24 Harrison, Jenna, 73.3 Hayara Odhiambo, 198.3 Hakem, Razq, 59.4 Han, Weiguo, 194.35 Harro, Carly, 138.22, Felix, 190.39 Guseva, Natalya, Haldar, Malay, 135.7 Han, Xiaozhe, 182.12 194.2 Hayer, Elisha, 130.14 178.13, 178.14 Halder, Ramesh, 126.8, Hanamsagar, Richa, Harshe, Rasika, 68.13, Hayes, Erika, 52.16 Gustafsson, Jenny, 132.5 131.15 182.10 Hayes, Tristan, 69.6, 129.17 Hale, J Scott, 186.3 Hancock, Wayne, Hart, Andrew, 129.4 181.2 Guthmiller, Jenna, 74.6 Haley, Jeaneen, 131.12 69.23, 137.1 Hart, Geoffrey, 76.16 Haymaker, Cara, 134.6 Gutierrez-Gonz´ alez,´ Haliloglu, Yesim, 193.12 Hand, Michelle, 132.9 Hartlage, Alex, 196.13 Haystead, Timothy, Mat´ıas, 177.1 Halimani, Mahantappa, Hand, Timothy, 191.16, Hartman, Douglas, 68.19 Gutierrez-Perez, Irene, 130.36 192.10, 198.2 135.5 Hayward, Sarah, 66.17, 65.6 Halkias, Joanna, Handelman, Samuel, Hartmann, Evelyn, 74.1, 129.2 Guyer, Rebecca, 67.21, 191.17 62.4 198.12 Hazel, Mark, 120.31 122.13 Hall, Benjamin, 62.10 Hangartner, Lars, 72.8 Hartmann, Gunther, S41 Hazen, Stanley, 191.12 Guzman, Jerry, 130.33 Hall, Brenna, 75.7 Hanisch, Philipp, 126.6 Hartwig, Stacey, He, Baokun, 193.2 Gwack, Yousang, 63.3 Hall, Bruce, 57.20, Hansch,¨ Sebastian, 139.11, 198.3, 198.7 He, Cheng, 130.40 Gwin, Kimberly, 53.20 116.16 126.6 Harty, John, 117.4, He, Chuan, 53.19 Gyurova, Ivayla, 76.7, Hall, Rachael, 186.11 Hansell, Peter, 182.47 129.14, 193.11, 198.7 He, Dongping, 132.4 76.10, 122.16 Hall, Samantha, 134.1 Hansen, Louis, 124.4 Harvey, Sarah, 126.34 He, Jianping, 67.11 Hall, Sannette, 62.6 Hansen, Michael, 126.5 Hasan, Farah, 189.10 He, Kun, 119.15 Haller, Susan, 132.4 Hao, Liuyi, 182.33 Hase, Koji, 191.4 He, Linling, 197.22 H Haller, Wolfram, 52.14 Hao, Stephanie, 130.4 Hasegawa, Akihiro, He, Xiao, 177.19, 188.11 Ha, Brendan, 130.15, Hall-Moore, Carla, Hao, Yu, 55.14 177.26 He, Xiumiao, 190.9 131.18, 182.27 126.3 Haque, Ashraful, 186.1 Haseltine, Derek, S23, He, Yan, 182.2 Ha, Jisu, 125.17 Haloul, Mohamed, Haque, Tamara, 54.11 S89 He, Zhaoren, 60.11, Ha, Seung Yeon, 136.13 190.38, 190.63 Harbison, James, Hasenkrug, Kim, 197.2 125.6 Ha, Taekjip, 64.13 Halpert, Richard, 130.29 182.43 Hasgur, Suheyla, 69.29 He, Zhiheng, 124.1

145 AUTHOR/SPEAKER INDEX

He, Ziyuan, 126.23 Heo, MinKyu, 189.15 Hester, Allison, 65.16 Hoebe, Kasper, 181.26, Horkowitz, Alex, 66.20 Head, Kelly, 190.61 Heo, Tae-Hwe, 52.11, Hester, Allison, 65.15, 182.28 Horn, Kadi, 182.22 Heaney, Thomas, 191.9 181.5 115.25 Hoeferlin, L., 64.9 Hornung, Veit, S41 Heath, William, 196.27 Herath, K.H.I.N.M, Hettinga,Angela,119.15 Hoek, Kristen, 192.2 Horuluoglu, Begum, Heatley, Susan, 187.12 187.31 Hewes, Becker, 136.20 Hoellbacher, Barbara, 182.21, 196.4 Hebbandi Nanjundappa, Herath, K.H.I.N.M., Hewitt, Stephen, 70.1 51.7 Hosakote, Yashoda, Roopa, 132.17 187.30 Hewlett, Elise, 182.69 Hoffman, Carol, 196.2 120.27, 120.28 Hedges, Jodi, 127.12 Herath, Kalahe Hewage Hezaveh,Kebria,197.10 Hoffman, Hal, 125.1 Hoshina, Naomi, 191.4 Hedrick, Andria, 64.26 Iresha Nadeeka Hibbert, Joseph, 130.11 Hoffman, Jonathon, Hoshino, Yoshihiko, Hedrick, Catherine, Madushani, 117.22, Hicar, Mark, 120.16 120.16 177.10 182.1 119.10 Hickling, Tim, 130.36 Hoft, Daniel, 137.9, Hossfeld, Austin, 190.66 Hedrick, Catherine, S6 Herbath, Melinda, 51.8, Hickman, Heather, 190.10 Hou, Dan, 50.17 Hedrick, Stephen, 190.40 56.19, 66.14, 75.18, Hoft, Stella, 190.78 Hou, Rong, 55.17 138.6, 188.8 Herberg, Jethro, 182.61 76.15, 139.20 Hogan, Andrew E., Hou, Xiaohong, 131.6, Heemskerk, Bianca, Herbert, De’Broski, Hicks, Sakeenah, S162 131.24, 131.25, 194.26 190.44, 192.8, 126.1, 123.8, 188.2 Hogarty, Michael, 131.28 Hegde, Bindu, 192.4 39, S34 Hiebert, Scott, 60.6 134.17 Houghton, A. McGarry, Hegemann, Johannes, Herbine, Karl, 126.1, Higgins, Jeanette, Hogben, Matthew, 135.3 126.18 190.44, 192.8 182.88 192.16 Houghton, Sean, 134.13 Heid, Bettina, 50.4, Herbst-Kralovetz, Higginson, Cody, 60.12 Hogge, Christopher, Houston, Stan, 120.2 50.13 Melissa, 75.5, 192.16 Higuchi, Kazuhide, 72.1, 72.2, 72.3, 75.20 Howard, Chanie, Heimberger, Amy, Hergerberg, C, S113 120.14, 195.14 Hogquist, Kristin A., 119.25 135.14 Herget, Georg, 53.18 Hii, Charles, 126.34 53.11, 53.16, S113 Howard, Emily, 51.12, Heinz, Sven, 187.21 Herman, James, 195.9 Hildebrand, William, Holbrook, Beth, 74.13 122.10 Heipertz, Erica, 64.5 Hermans, Ian, 196.27 71.15, 195.12 Holian, Andrij, 117.6, Howe, Charles, 180.1 Hejazi, Nazila, 194.12 Hermanson, Payton, Hill, Geoffrey, 69.10, 117.7 Howe, Kathleen, 190.59 Heller, Loree, 64.10 182.26 69.38, 69.42 Holl, Eda, 129.11, 136.9 Howe, Matthew, 76.16 Heller, Nicola, 59.15 Hernandez Escalante, Hill, Timothy, 60.6 Holland, Steven, 137.13 Howe, Philip, 57.12 Heller, Richard, 136.2, Jaileene, 125.2 Hillman, Elizabeth, S88 Hollingsworth, Michael, Howe, Savannah, 67.5, 194.25 Hernandez Perez, Hinchcliff, Monique, 135.15 190.80, 196.9 Hellmers, Linh, 133.16 Sara, 177.12 182.37 Holowka, Thomas, 51.9 Howell, Amy, 177.1 Helmold Hait, Sabrina, Hernandez, Alfredo, Hinderlie, Peter, 136.22 Holstein, Amanda, Howell, Justin, 194.30 72.1, 140.9 51.13 Hioe, Catarina, 197.17 57.17, 124.8 Howell, William, 179.15, Helmsdoerfer, Kristen, Hernandez, Gilberto, Hirahara, Kiyoshi, 54.3 Holt, Marie, 120.33 179.16 193.5 190.43 Hirai, Toshiro, 116.10 Holtz, Nevine, 130.30 Hoxha, Ori, 51.20 Hemann, Emily, 74.3 Hernandez, Gloria, Hiramoto, Emiri, 123.3 Holz, Lauren, 196.27 Hoyer, Katrina, 115.17, Hematti, Peiman, 69.2, 118.1 Hirano, Masayuki, 73.1 Holzel, Michael, 138.2 115.22, 190.74 69.39 Hernandez-Hern´ andez,´ Hirose, Sachiko, 183.16 Homann, Dirk, 76.1 Hozain, Sarah, 58.14 Hemming, Matthew, Jose,´ 51.3 Hirsch, Aspen, 188.17 Honaker, Christa, 73.8 Hritzo, Molly, 186.4 69.42 Hernandez-Solis,´ Hirst, Martin, 55.7 Hong, Huixian, 115.1 Hrusch, Cara, 67.22, Henao-Tamayo, Alejandro, 190.86 Hitomi, Kaori, 62.18 Hong, Jin Tae, 51.17, 119.25 Marcela, 139.5 Herndon, David, Hitosugi, Taro, 60.2 134.20 Hrytsenko, Olga, 70.2 Henden, Andrea, 69.38 126.13, 187.25 Hiwale, Ankita, 192.4 Hong, Li, 130.40 Hsieh, Chyi, 129.17 Henderson, Heidi, 72.9 Herr, Andrew, 181.26, Ho, Chen-Hsuan, Hontecillas, Raquel, Hsieh, Elena, 52.1 Henderson, Jacob, 182.28 135.19 132.7 Hsieh, Li-En, 57.4 194.41 Herrera de la Mata, Ho, I-Cheng, 124.2 Ho¨og,¨ Charlotte, 65.6, Hsieh, Shie-Liang, S79 Henderson, Paul, 70.1 Sara, 65.3, 140.11 Ho, Jonathan, 182.49 187.10 Hsiung, Sunnie, 53.23 Hendricks, Alissa, Herrera, Natalia, 182.56 Ho, Sharon, 191.1 Hoolehan,Walker,53.24 Hsu, Amy, 76.16 194.30 Herro, Rana, 182.1 Hoang, Tanya, 72.1, Hoover, Paul, S209 Hsu, Fan-Chi, 56.15 Henig, Israel, 56.6 Hertwig, Laura, 51.5 72.2, 72.3, 72.5, Hope, Jennifer, 117.25 Hsu, Haoting, 73.23 Henke, Travis, 121.5 Hertz, Alexandria, 75.20, 140.9, 197.1 Hopkins, Forrest, 190.33 Hsu, Hui-Chen, 115.1, Henn, Alicia, 131.14 130.11 Hoang, Thomas, 193.2 Hopp, Christine, 179.5, 179.10 Henriquez, Claudio, Herzenberg, Leonore, Hobbs, Samuel, 117.16 190.45, S34 Hsu, Katharine, 76.3 73.19 188.11 Hodel, Ashley, 182.67 Hoppener,¨ Stephanie, Hsu, Ku-Lung, 71.7 Henriquez, Monique, Herzig, Eytan, 197.2 Hodes, Richard, 53.13, 59.5 Hsu, Martin, 117.13, 117.25 Herzog, Nora, 136.6 183.13 Hor, Jyh Liang, 138.2 121.10 Henry, Brittany, 181.3 Heslop, Helen, 71.8 Hodge, Deborah, S152 Horai, Reiko, 190.54, Hsu, Matthew, 71.19 Henry, Curtis, 65.8 Hess, Christoph, Hodge, Johnie, 194.11 191.6 Hsu, Phillip, 53.19 Henry, William, 62.10 125.15 Hodge, Tracey, 131.12 Hordvik, Ivar, 73.6 Hsu, Yu-Hua, 117.12 Hentze, Hannes, 131.10 Hess, Nicholas, 69.2 Hodgkinson, Suzanne, Horejs-Hoeck, Utta, Hsueh, Eddy, 137.9 Heo, David, 131.22 Hessell, Ann, 72.9 57.20, 116.16, 186.11 70.23 Hu, Anka, 182.12

146 AUTHOR/SPEAKER INDEX

Hu, Hao, 116.5 Huante,Matthew,127.17 I Irvine, Darrell, 121.9 Jacobsen, Elizabeth, Hu, Peisheng, 122.10 Hubbell, Jeffrey, 196.20 Isaacs, John, 179.9 69.9 Iacomini, John, 69.31, Hu, Qianni, 69.45 Huda, Ruksana, 68.3 Ishak, Heather, 119.14 Jacobsen, Kivin, 131.4, 69.40 Hu, Wen-Yuan, 180.2 Hudgens,Edward,73.23 Ishida-Yamamoto, 131.13 Iamsawat, Supinya, Hu, Xiaoyu, 58.5 Hudig, Dorothy, 182.50 Akemi, 126.30 Jacobson, Kenneth, 57.12 Hu, Xintao, 72.4 Huemer, Martina, 56.10 Ishikawa, Tatsuya, 119.18 Ianniello, Alice, 52.2 Hu, Yanfen, 195.17 Huggins, Matthew, 182.73 Jacobson, Kevan, Ibarra, Claudia, 182.8 Hu, Yawen, 187.14 190.19 Iskandar, Mina, 181.18 192.3 Ibba, Salome, 119.9 Hu, Yi, 188.12 Hughes, Michael, 55.7, Islam, S M Shamsul, Jacobson, Scott, 119.5 Ibegbu, Chris, 76.6 Hu, Yinghong, 60.17 58.3 117.24 Jacobson, Steven, Iberg, Aimee, 70.21 Hu, Yi-Zhen, 57.21 Hughes, Phillip, 68.19 Ismaeel, Sana, 63.5 193.14 Ibrahim, Mohammed L., Hu, Zheng, 182.18 Hughes, Travis, 190.41 Ismail, Nahed, 190.38, Jacquier, Steven, 194.8, 195.26 Hua, Ping, 195.31 Hui, Yvonne, 185.4, 190.51, 190.63 190.59 Ibrahim, Safaa, 137.14 Hua, Yuan, 178.18 190.30 Ismail, Nevien, 196.29 Jaffar, Zeina, 119.28 Ibrahimova, Shalala, Hulbert, Chrys, 115.14 Itani, Farah, 193.11 Jagannath, Huang, Duen-Yi, 51.16 182.5 Hulsd¨ unker,¨ Jan, 69.38 Itkin, Max, 51.5, 189.7 Chinnaswamy, 62.14, Huang, Yinghui, Ibsen, Eric, 131.10 Ito, Ichiaki, 126.13, 120.10, 177.17 138.17, 138.21 Hum, Nicholas, 75.24 Icedo-Zamora, 187.25, 192.15 Jagannathan, Sajjeev, Huang, Alex, 51.21 Humeau, Laurent, 70.4 Salvador, 70.17, 125.13 Huang, Chen-Wei, Humrich, Sarah, 125.8 131.17 Ito, Mamoru, 129.15, Jager,¨ Elisabeth, 59.5 135.19 Hunegnaw, Ruth, Ichiya, Tamaki, 187.10 131.31 Jain, Dharmendra, Huang, Chih-Ting, 140.9, 197.1 Idowu, Michael, 194.7 Itri, Vincenza, 197.17 69.12 191.8 Hung, Chen-Yiu, 57.16, Igawa, Satomi, 122.15, Ivanov, Andrey, 187.35 Huang, Ching-Tai, 74.4 126.30 Ivanova, Daria, 190.52, Jain, Dharmendra, 57.16, 74.4 Hung, Chien-Fu, 70.11, Iglesias Lozano, 190.53, 190.72, 69.20 Huang, Deli, 72.8, 196.21 Marcos, 68.15, 69.32, 190.73 Jain, Pooja, 75.16 178.6, 187.6 Hung,Kuo-Hsuan,185.8 69.33, 116.8 Ivarsson, Martin, 51.5 Jain, Reema, 53.9 Huang, Fei, 195.10 Hung, LiYin, 126.1 Ignatowicz, Leszek, 52.5 Ivey, Michael, 190.9 Jain, Rohit, 122.11 Huang, Feng, 50.17 Hung, Li-Yin, 190.44, Iijima, Koji, 55.2 Ivey, Mike, 190.14 Jain, Sanjay, 194.36 Huang, Hai, 135.2 192.8 Iijima, Norifumi, 129.16 Iwanaga, Naoki, 139.7, Jaiswal, Abhinav, 137.3 Huang, Haley, 70.7 Hunka, Julia, 67.17, Ikeda, Yumi, 182.23 139.8 Jaiswal, Anil Kumar, Huang, Haochu, 53.19 73.14 Iliev, Iliyan, 191.3 Iwasaki, Akiko, 56.9, 55.16 Huang, Hsiao Han, Hunsberger, Benjamin, Illing, Patricia, 74.12 62.7, 129.16, 194.28 Jaiswal, Hemant, 60.4 73.22 131.2 Im, Jiyoung, 70.6, Iwashima, Makio, 184.9 Jajja, Mohammad Huang, Hsin-I, 126.35, Hunter, Christopher, 195.15 Iwata, Terri, 64.18 Raheel, 71.2 135.1 122.5, 190.11, S40 Im, John, 121.11, 195.6 Iwaya, Hitoshi, 53.3, Jakobsen, Martin, 66.12 Huang, Huai-Cheng, Huo, Longfei, 135.14 Imam, Tanbeena, 69.6 67.18, 129.7, 191.11 Jala, Venkatakrishna, 57.12 Huppler, Anna, 75.3 Imbratta, Claire, 194.3 Iyer, Gopal, 70.5 192.4 Huang, Huakang, Hurrell, Benjamin, Imperato, Gavin, 133.17 Iyer, Namrata, 67.14 Jamali, Arsia, 117.15 181.11 51.12, 122.10 In, Hyunju, 118.4, Izawa, Kumi, 54.8 Jamann, Hel´ ene,` 181.8 Huang, Jing, 186.5 Hurt, Aeron, 74.12 119.24, 177.4, 177.13 Izumi, Gentaro, 119.23 James, John, 52.14 Huang, Jun, 184.10 Husain, Mushtaq, 140.4 Incarnato, Danny, 52.2 Izzo, Linda, 62.12 James, Judith, 118.7 Huang, Lu, 190.23 Husain-Krautter, Ince, Louise, 117.3 James, Kylie, 186.1 Huang, Min-Nung, 70.20 Sehba, 121.6 James, Richard, 54.1 Incrocci, Ryan, 119.11, J Huang, Nick, 115.6 Huse, Morgan, 76.3 133.13 James, Stephanie, Huang, Nongyu, 117.9 Hussain, Shah, 190.51 Inglis, G. Douglas, Jachimowicz, Lauren, 75.21 Huang, Paul, 133.5 Hussain, Syed-Rehan 73.15, 192.19 130.17 Jameson, Julie, 52.18 Huang, Shih-Jung, A., 55.13 Inoue, Maia, 189.3 Jacks, Ramiah, 184.9 Jameson, Stephen, 57.21 Hussain, Tabinda, 60.7 Insel, Paul, 122.15 Jackson, Benjamin, 76.3 56.13 Huang, Shiran, 194.18 Hutcheon, Carolyn, 59.6 Invernizzi, Pietro, 179.3 Jackson, David, 74.12, Jamieson, Amanda, Huang, Shuyu, 69.10 Huynh, Larry, 182.32 Inwentarz, Sandra, 194.35 62.10, S25 Huang, Stanley, 181.28 Hwang, Da-Bin, 196.25 190.79 Jackson, Dominique, Jamison, Braxton, 68.5 Huang, Tao, 71.7 Hwang, Haun, 186.7 Iovino, Lorenzo, 53.9 183.4 Jan, Muzafar, 197.17 Huang, Weishan, 55.20, Hwang, Mi-Hyun, 185.3 Ip, Blanche, 182.25 Jackson, Ruaidhri, Janardhan, 69.4, 140.1, 189.11 Hwang, Shen-An, Ipinmoroti, Ayodeji, 129.9 Kyathanahalli, 51.14 Huang, Wendy, 125.20 130.22, 131.26 196.10 Jackson, Taryn, 57.21 Jang, Nayoon, 117.2 Huang, Xiangsheng, Hwu, Patrick, 134.6 Ippolito, Gregory, 71.15 Jackson, Tim, 130.30 Jang, Young-Saeng, 191.15 Hyde, Michael, 69.40 Iqbal, Salma, 64.23 Jackson, William, 67.2 Huang, Xing, 120.17 Hylander, Bonnie, Irani, Vashti, S34 119.21 Janga, Sarath, 69.6 Huang, Yina, 138.1 136.27, 195.23 Irazoqui, Javier, 64.6 Jacob, Sam, 192.15 Janoff, Edward, 72.12 Huang, Zhaofeng, 124.1 Hyzny, Eric, 122.3, Iritani, Brian, 64.18 Jacobs, Aaron, 194.12 Janowska, Iga, 53.18 Huang, Zhe, 121.4 128.3, 128.11 Irons, Eric, 188.6 Jacobs, Jesica, 115.18 Jansen, Nicole, 130.27

147 AUTHOR/SPEAKER INDEX

Janssen, Edith, 181.26, Ji, Xiaoping, 134.16 Johnson, Kaitlin, 75.3, Juneja, Vikram, 195.31 Kamada, Nobuhiko, 195.34 Ji, Xin, 131.33 75.9 Jung, Bock-Gie, 63.7 191.2 Jaroch, David, 71.1, Ji, Yingbiao, 190.44, Johnson, Lexus, 134.4 Jung, Da-Eun, 187.11 Kambayashi, Taku, 130.1 192.8 Johnson, Marc, 74.10 Jung, Da-Jung, 121.3 58.8, 69.4, 126.1 Jaroszewski, Jerzy, Jia, Ping, 190.21 Johnson, Margarete, Jung, Ho-Hyun, 177.2 Kamdar, Rahul, 130.2 68.2, 73.10 Jia, Yiqun, 190.64 60.12 Jung, Jae, 63.3 Kamenecka, Theodore, Jarvi, Susan, 190.59 Jian, Dan, 55.5 Johnson, Matthew, Jung, Minho, 126.40 68.11, 183.10 Jasiecka-Mikolajczyk, Jiang, Jiansheng, 182.65, 184.8 Jung, Yong Woo, Kamenyeva, Olena, Agnieszka, 73.10 177.15, 177.31 Johnson, Paul, 76.6 189.13, 195.22 75.18 Jasiecka-Mikołajczyk, Jiang, Jingting, 195.8 John-Stewart, Grace, Jung, Yu-Jin, 139.12, Kamenyeva, Olena, Agnieszka, 68.2 Jiang, Pengfei, 194.22 66.10 139.18 57.17, 124.8, 130.2, Jaspan, Heather, 72.10 Jiang, Ruo-Lan, 128.2 Johnston, Stephen, Jurewicz, Mollie, 177.28 190.82 Jassem, Nuhad, 61.21 Jiang, Shaowei, 178.9 197.18 Jurutka, Peter, 66.6 Kaminski, Marcin, 56.10 Jay, Bryanna, 75.10 Jiang, Timothy, 60.9 Joldrichsen, Marisa, Jutila, Mark, 127.12 Kampen, Robert, Jean-Pierre, Makheni, Jiang, Wei, 120.1 119.4 186.10 181.11 Jiang, Weiping, 130.24, Joly, Pascal, 179.6 Kamradt, Thomas, S41 Jee, Y., 187.30 130.25, 194.38, Joly, Rifka, 61.21 K Kanashiro, Alexandre, Jee, Youngheun, 187.31 194.40 Jondle, Christopher, Kabashima, Kenji, 182.82 Jeffrey, Michael, 191.18 Jiang, Xiaodong, 129.9, 75.3, 75.9 126.33 Kancharla, Aravind, Jeffreys, Sean, 123.4 194.28 Jones, Albert, 125.2, Kabat, Juraj, 57.17, 137.8 Jeffries, Joseph, 194.10 Jiang, Xiaoling, 136.12 182.25 124.8, 128.6, 130.2 Kandar, Bojidar, 182.70 Jenkins, Meagan, 56.18 Jiao, Jing, 137.1 Jones, Brian, 57.9 Kabata, Hiroki, 191.3 Kandefer, Rachel, Jenks, Scott, 50.10 Jiao, Yang, 195.11 Jones, Derek, 188.3 Kabbout, Mohamed, 182.70 Jensen, Federico, Jimenez´ Mart´ınez, Jones, Devin, 64.3, 70.1 Kane, Lawrence, 184.1 123.19 Mar´ıa C., 55.19 117.11, 128.8 Kaber, Gernot, 52.15 Kanegaye, John, Jensen, Isaac, 117.4 Jin, Dong-Yan, 127.4, Jones, Douglas, 71.10 Kadavallore, Asha, 182.61 Jensen, Michael, 71.16 127.6 Jones, Helen, 181.26 186.12 Kang, Byunghyun, Jensen, Peter, 177.19, Jin, Fang, 56.20, 76.2, Jones, Kylee, 130.13, Kader, Muhamuda, 67.11 188.11 126.5, 183.19 131.21 190.51, 190.63 Kang, Hee, 122.17 Jeon, Insu, 70.6, 195.15 Jin, Ge, 181.25 Jones, Mark, 56.7, Kaech, Susan, 60.17, Kang, Inkyung, 180.11 Jeon, Saebom, 126.15 Jin, Liliang, 62.5, 62.17, 117.18, 190.71 66.24, 129.9, S17 Kang, Insoo, 181.22, Jeon, Y., 187.30 126.24 Jones, MaryJane, Kaempf, Andy, 120.12 S91 Jeon, You-Jin, 117.22, Jin, Wenjie, 140.17 55.15, 190.8 Kaforou, Myrsini, Kang, Karen, 131.32 119.10, 187.31 Jin, Ye, 115.21, 128.16 Jones, Matthew, 66.22 182.61 Kang, Kyung-Sun, Jeong, Brian, 119.3 Jin, Yining, 55.5, 55.6 Jones, Stephen, 129.1 Kagan, Valerian, 58.18 182.9 Jeong, Hana, 187.24 Jittayasothorn, Yingyos, Jones, Steven, 194.41 Kahn, Daniel, 182.64 Kang, Kyung-Won, Jeong, hYUNJU, 180.6, 191.6, 193.1 Jones, Tamekia, 198.11 Kain, Lisa, 120.33 56.22 183.11 Jiyarom, Boonyanudh, Jones, Thomas, 131.1 Kaitani, Ayako, 54.8 Kang, Lan, 58.5 Jeong, Seong-Un, 197.13 Joo, Dong Jin, 120.8 Kakugawa, Kiyokazu, Kang, Sang W., 190.55 177.2, 177.3 Jo, Jay Hyun, 58.12 Jorapur, Aparna, 119.5 53.3, 62.18, 67.18 Kang, Sang-Moo, Jeong, Soyoung, 127.24 Jo, Myung Hyun, 64.13 Jordan, Kimberly, 52.1 Kalabokis, Vassilios, 139.12, 139.18 Jeong, Young-Jin, 52.11 Jo, Yeara, 185.7, 187.28 Jordan, Martha, 69.4 124.4 Kang, Shin Myung, Jeong, Yunhee, 126.22 Joe, Bina, 182.6 Jorgensen, Christian, Kalams, Spyros, 72.7 136.13 Jergovic, Mladen, 189.2 Johnson, Jeffrey, 51.15 50.12 Kalayjian, Robert, Kang, Tae Jin, 119.8 Jerome, Jacob, 59.7 Johnson, Aaron, 56.20, Jorgensen, Rick, 55.5, 120.32 Kang, Tae-Seung, 70.6, Jeschke, Jonathan, 76.2, 126.5, 183.19, 55.6 Kale, Sagar, 119.15 195.15 192.21 190.19, 194.19 Joseph, Biju, 182.82 Kalia, Vandana, 60.15, Kang, Yu Jeong, 51.17 Jessup, J., 70.1, 136.8 Johnson, Adam, 71.16, Joseph, Igietseme,, 71.16, 181.24 Kania, Anna, 123.8, Jeyaseelan, 133.3 126.32 Kalies, Axel, 57.19 188.15 Samithamby, 62.5, Johnson, Cory, 195.24 Joshi, Hemant, 117.14 Kalinina, Olga, 69.37 Kanneganti, Thirumala- 62.17, 126.24 Johnson, Deborah, Jost, Stephanie, 76.4 Kallies, Axel, 125.18, Devi, 64.25, 74.8, Jeziorski, Eric, 50.12 196.16 Joubert, Isabella, 70.23 140.16, 189.1 187.5 Jha, Vibha, 72.12 Johnson, De’sha, Jovanovic, Vida, 130.14 Kalmokoff, Martin, Kant, Shashi, 132.8 Jhaveri, Aditi, 193.13 190.70 Joyce, Sebastian, 60.6, 191.18 Kantor, Aaron, 188.11 Jhita, Navdeep, 196.7 Johnson, Erica, 126.28 73.2 Kaluna, Lisa, 190.59 Kao, Cheng-Yuan, Ji, Ju, 58.16 Johnson, Jarrod, 75.11 Juarez, Patricia, 138.10 Kalunian, Kenneth, 191.8 Ji, Junyi, 192.10 Johnson, Jeffrey, Judge, Sean, 126.27 182.8 Kao, Elaine, 194.20 Ji, Liangliang, 58.5 137.11 Julio Faller, Cristiano, Kalyanasundaram, Kaplan, Barbara, Ji, Niannian, 136.14 Johnson, Jenny, 56.7 63.6 Shiva, 61.20 180.12 Ji, Shaoquan, 130.24, Johnson, John, 190.44 Jun, Chang-Duk, 56.5 Kam, Lance, 128.18 Kaplan, Daniel, 116.10 130.25, 194.40 Johnson, Joseph, 52.21 June, Carl, 134.4 Kam, Yoonseok, 56.16 Kaplan, Mariana, 182.21

148 AUTHOR/SPEAKER INDEX

Kaplan, Mark, 69.6, Kauffman, Keith, Kenison-White, Khomtchouk, Kelly, Kim, Pyeung-Hyeun, 119.13, 122.12, 128.5, 190.78, 190.82 Jessica, 193.13 190.76 67.2, 191.11 128.14, 181.2, 182.41 Kaufmann, Eva, 190.27 Kennedy, Paul, 137.11 Khoriaty, Rami, 56.6 Kim, Sang Hoon, 195.22 Kapoor, Amit, 196.13 Kaur, Deepinder, 190.35 Kennedy, Rebekah, Khoryati, Liliane, 207.1 Kim, Sang Yong, 185.9 Karabin, Nicholas, Kaur, Jaspreet, 126.34 55.3 Khuat, Lam, 56.17, Kim, Sang-Hyun, 177.3 132.15 Kaur, Kamaljeet, 119.26 Kennedy-Darling, Julia, 69.36 Kim, Seyoung, 56.22 Karageorgos, Spyridon, Kaur, Pali, 182.67 130.23 Khurana, Priya, 134.17 Kim, Sojeong, 189.15 134.17 Kaushal, Deepak, Kennelley, Hannah, Khwaja, Shariq, 195.24 Kim, Soohyun, S91 Karakousis, Petros, 190.79 51.21 Kibiy, Angela, 182.88 Kim, Stephanie, 56.6 125.19 Kawai, Tatsuo, 69.8 Kenyon, Amanda, 61.2 Kijak, Julie, 117.13, Kim, Tae-Jin, 56.21 Karall, Daniela, 56.10 Kawakami, Yu, 54.4, Kenyon, Lawrence, 121.10 Kim, Wooseob, 123.12 Karandikar, Nitin, 183.8 126.17 Killeen, Meaghan, 125.3 Kim, Ye Seon, 187.3 57.11, 57.13, 115.9, Kay, Alexander, 62.21 Kepler, Thomas, 198.14 Kim*, Jean, 120.13 Kim, Yong Chan, 193.14 178.14, 193.11 Kaye, Jonathan, 53.1, Kern, Philip, 182.25 Kim, Areum, 119.10, Kim, Yong-Hee, 57.22, Karasuyama, Hajime, 186.12 Kerr, Katie, 73.11 187.31 69.15 126.2 Kayentao, Kassoum, Kersh, Ellen, 192.16 Kim, Bong-Hyun, 67.11 Kim, Yoo, 182.35 Karayigit, Mehmet, 126.7 Kesari, Santosh, 194.22 Kim, Bong-Sung, 51.9 Kim, You-Me, 121.3 193.12 Kayraklioglu, Neslihan, Keselman, Aleksander, Kim, Brian S., 133.5, Kim, Young, 134.19, Karbach, Susanne, 182.21, 196.4 59.15 S141 135.26 181.4 Kaza, Vaidehi, 69.30 Kessenbrock, Kai, Kim, Dae, 197.5 Kim, Youngjun, 191.3 Karbarz, Emily, 119.5 Kazemian, Majid, 69.6, 135.4, 193.10 Kim, Dong Hyun, 181.6 Kim, Youngsoo, 187.11 Karcz, Tadeusz, 117.1, 125.5, 125.15 Kessler, Patricia, 185.3 Kim, Dong-Eon, 124.15 Kim, Yu Ri, 119.8 119.18 Ke, Fang, 121.15 Ketcham, John, 119.5 Kim, Doyoung, 58.12 Kimbara, Michelle, Kargl, Julia, 135.3 Ke, Hengning, 194.13 Khadka, Roman, 76.2, Kim, Ellen, 177.15 71.19 Kari, Suresh, 137.8, Keating, Rachael, 74.6 183.19 Kim, Eunsoo, 55.4, Kimura, Koki, 182.7 195.17 Kedzierska, Katherine, Khalaf, Omar, 190.31 119.4 Kinard, Jessica, 67.15 Karimi, Mobin, 69.4 74.12, 196.27 Khalil, Mirna, 50.12 Kim, Ga-young, 187.24 King, Aspen, 67.19 Karin, Michael, 125.1, Kedzierski, Lukasz, Khalil, Natalie, 196.12 Kim, Gil-Ran, 193.4 King, Irah, 190.27, S154 190.6 196.27 Khan, ANM Nazmul, Kim, H.J., 187.30 King, Lindsay, 130.36 Karki, Rajendra, 187.5 Kee, Barbara, 65.2, 137.13 Kim, Hee Jung, 181.5 King, Philip, 125.14 Karlsson Hedestam, 65.10 Khan, Arshad, 62.14, Kim, Heejoo, 115.10, King, Rodney, 188.18 Gunilla, 72.9 Kee, Sydney, 185.5 120.10, 177.17 186.3 Kink, John, 69.39 Karmakar, Aditi, 193.5 Keefe, Caitlin, 75.21 Khan, Aslam, 185.13 Kim, Hong-Il, 190.25 Kinkhabwala, Ali, 130.27 Karmakar, Subir, Keegan, Achsah, Khan, Deena, 50.4 Kim, Hye sun, 117.2 Kinner-Bibeau, Lauren, 196.29 119.21, 186.4 Khan, Naazneen, 130.5 Kim, Hye Young, 122.7 59.10 Karpova, Tatiana, 56.11 Keele, Brandon, 72.6 Khan, Nargis, 190.27 Kim, Hye-Jung, 196.25 Kinsella, Sinead,´ 53.9 Karpurapu, Manjula, Keenan, Lisa, 52.22 Khan, Pavana, 187.18 Kim, Hye-Ran, 56.5 Kinuthia, Jon, 66.10 119.19 Keenum, M., 196.7 Khan, Reas, 126.17 Kim, Hyo Jin, 117.22 Kirchenbaum, Greg, Karpus, William, 117.13 Keesen, Tatjana, Khan, Shahanshah, Kim, Hyoung-Pyo, 139.19, 139.23 Karsalia, Ritesh, 125.7 120.15, 140.20 187.34 118.5 Kirchherr, Jenn, 197.14 Kartashov, Andrey, Keeter, William, 121.14, Khan, Shaheen, 182.32 Kim, Hyun Young, Kiripolsky, Jeremy, 125.13 122.12, 182.75 Khan, Wasif, 179.13 127.24 180.10 Kasakura, Kazumi, Keezer, Mark, 181.8 Khan, Zafar, 75.16 Kim, Hyung Sook, Kirk, Allan, 186.10 54.4, 183.8 Keller, Ashleigh, 189.5 Khanal, Santosh, 52.1 51.17, 134.20 Kirk, Sean, 187.1, 187.2 Kashanchi, Fatah, Kelley, Holden, 62.20 Khanam, Arshi, 140.19 Kim, Il-Kyu, 195.15 Kirkwood, John, 195.9 75.16 Kelliher, Michelle, 59.4 Khandekar, Durga, Kim, Jaemoo, 139.15 Kirou, Kyriakos, 50.8 Kasperek, Eileen, Kelly, Clare, 194.10 70.10 Kim, Jong Hoon, 120.8 Kirschner, Denise, 180.10 Kelly, Joseph, 129.9 Khanna, Kamal, 126.14 Kim, Joohyung, 179.11 182.86 Kasprzak, Victoria, 54.1 Kelly, Nancy, 120.9 Kharlampieva, Kim, Joseph, 130.23 Kirwin, Stefanie, 193.5 Kastenschmidt, Jenna, Kelly, Ryan, 53.4 Eugenia, 69.19 Kim, Junhyong, 126.22 Kirychuk, Shelley, 183.20 Kelly-Scumpia, Kindra, Kharwadkar, Rakshin, Kim, Juyang, 190.55 119.30 Katafiasz, Dawn, 62.6 58.13, 120.25 119.13, 128.5, 128.14 Kim, Ki-Hye, 139.12, Kish, Danielle, 55.8, 55.9 Katano, Ikumi, 131.31 Kelsall, Brian, 67.11 Khatua, Atanu, 63.2 139.18 Kishimoto, Hidehiro, Katara, Gajendra, Kelsey, Lauren, 130.30 Khayumbi, Jeremiah, Kim, Kun Woo, 136.13 130.32 129.10, 137.14 Kemboi, Edna, 186.17 190.39 Kim, Kyong Hoon, Kissel, Lee, 121.10 Katepalli,Madhu,190.31 Kemeny, Hanna, 186.15 Khedri, Zahra, 130.5 189.13 Kita, Hirohito, 55.2, Kathuria, Noshin, 117.23 Kemper, Claudia, Kheradmand, Farrah, Kim, Kyungjae, 177.2 119.27 Katırcı, Ertan, 59.14 56.10, 125.5, 125.15, 194.23 Kim, Mi Eun, 58.7, Kita, Yoshihiro, 182.42 Kato, Kazunori, 194.24 S77 Khetani, Vikram, 182.88 195.19 Kitaura, Jiro, 54.8 Katz, Haley, 69.18 Kendall, Peggy, 115.14, Khiew, Stella, 69.12 Kim, Minhyung, 181.22 Kitoh, Akihiko, 126.33 Katz,Steven,71.1,130.1 178.17 Khodoun, Marat, 132.8 Kim, Miriam, 115.2 Kiuchi, Masahiro, 54.3

149 AUTHOR/SPEAKER INDEX

Kiwanuka, Kasalina, Kobayashi, Makiko, Konradt, Christoph, Kozlov, Shawn, 194.30 Kugadas, Abirami, 54.13 126.13, 187.25, 122.5 Kozlovskaya, Veronika, 127.22 Kiyono, Hiroshi, 54.3 192.15 Konstantinidis, Lukas, 69.19 Kugler-Umana, Olivia, Klapholz, Max, 137.15 Kobayashi, Tetsuro, 53.18 Kozon, Nathan, 119.5 198.5 Klasener,¨ Kathrin, 58.12 Konuk, Esma, 59.14 Kraft, Peter, 126.25 Kuhn, Thomas, 131.39 75.25 Kobayashi, Yasuhiro, Kopin, David, 70.20 Kraig, Ellen, 115.25 Kuhns, Douglas, 182.17 Kleiman, Eden, 179.13 181.28 Kopp, Sarah, 140.3 Kraj, Piotr, 52.5 Kuipers, Hedwich, Klein, Bruce, 70.19, Kobayshi, Takao, 55.2 Koppang, Erling Olaf, Kramer, Jill, 180.10 52.15, 119.14 190.17 Kobie, James, 72.9 73.6 Kramer, Kevin, 138.7 Kulkarni, Devesha, Klein, John, 50.1 Koble, Jessica, 190.14 Korbutt, Gregory, 69.19 Kranz, David, 177.30 129.17 Klein, Sarah, 195.31 Kodal, Behiye, 136.22 Kordbacheh, Farzaneh, Kraus, Aurora, 73.5 Kulkarni, Hrishikesh, Klein, Walter, 120.22 Koganti, Lahari, 195.3 183.3 Kraus, Felix, 60.7 69.21 Kleinerman, Eugenie, Koh, Byunghee, Koreth, John, 69.42 Krauthauser,¨ Susanne, Kulkarni, Smita, 75.17, 135.13, 187.16 119.13, 128.14 Korn, Thomas, 181.4 130.27 120.3 Kleinschnitz, Christoph, Koh, Choong-Hyun, Kornberg, Adam, 195.3 Kreisel, Daniel, 69.9, Kulshrestha, Arpita, 126.25 70.6, 195.15 Kornbluth, Jacki, 127.9 69.21 137.14 Kleinstein, Steven, Koh, June-Young, 120.8 Kornbluth, Richard, Krementsov, Dimitry, Kumamoto, Alice, 133.7 130.26 Kohanski, Michael, 196.6 50.3, 178.3, 187.26, Kumamoto, Yosuke, Klement, John, 195.26 192.8 Kornepati, Anand, 192.5 56.9 Klement, John D., 194.8 Kohl,¨ Jorg,¨ 181.9 195.17 Krempski, James, 55.2 Kumar, Ajay, 65.9 Klicznik, Maria, 51.7 Kohlmeier, Alison, 51.15 Korotchenko, Evgeniia, Kreutz, Marina, 137.1 Kumar, Amrendra, 60.6, Kline, Douglas, 135.21 Kohlmeier, Jacob, 70.23 Kreymborg, Katharina, 73.2 Kline, Justin, 135.6 66.17, 74.1, 76.14, Korrer, Michael, 134.19 69.10 Kumar, Amrita, 139.17 Klinman, Dennis, 129.2, 192.16, S25 Korty, Patricia, 116.13 Krieger, Stephanie, Kumar, Anil, 129.5 182.21, 196.4 Kohn, Alison, 54.9 Kosaka, Yoko, 195.10 182.15 Kumar, Arvind, 196.13 Klocke, Barbara, Kojetin, Douglas, 68.6 Kosaloglu Yalcin, Krikki, Ioanna, 128.17 Kumar, Ashok, 64.23, 192.20 Kokaji, Andy, 58.3, Zeynep, 70.16 Krishack, Paulette, 127.19, 183.12 Klonowski, Kim, 128.15 71.3, 130.14, 130.18 Kosaloglu-Yalcin, 67.22, 119.25 Kumar, Dharmendra, Klopfenstein, Nathan, Kokkinou, Efthymia, Zeynep, 134.1 Kroeger, Jodi, 138.22 66.4 64.4 65.6, 187.10 Kosanke, Stanley, 64.26 Kroger, Charles, 68.14 Kumar, Gaurav, 193.9, Klotz, Stephen, 126.11, Kolawole, Elizabeth, Koshkaryev, Alexander, Krogfelt, Karen, 192.3 193.15 140.22 76.13 195.11 Krogsgaard, Michelle, Kumar, Jai, 120.24, Knight, Katherine, Kolbe, Jess, 190.9 Kosiewicz, Michele, 194.5 181.23 69.37, 119.11, 190.47 Kole, Hemanta, 178.1 178.18 Kronenberg, Mitchell, Kumar, Pawan, 181.7, Knight, Robert, 130.1 Kole, Hemanta K, Kosik, Ivan, 139.20 62.18, 65.1, 65.3, 181.11, 191.16 Knodler, Leigh, 190.6 178.2, 179.1 Kosikova, Martina, 67.8, 131.18, 140.4, Kumar, Princy, 182.88 Knoell, Daren, 62.6 Koleva, Petya, 57.5 139.20 182.27, 191.11 Kumar, Sandeep, Knoop, Kathryn, 126.3 Koliesnik, Ievgen, Kossenkov, Andrew, Kronman, Chanoch, 195.11 Knopick, Peter, 135.27 52.15, 119.14 118.2 187.32 Kumar, Sudeep, 139.6 Knott, Jeffery, 67.20 Kolitz, Jonathan, Kotb, Malak, 120.30 Krueger, Janna, 136.24 Kumar, Vipin, 57.10, Knowlton, Hannah, 182.62 Kotera, Ryoma, 177.26 Krummel, Matthew, 132.5 132.14 Kolling, Fred, 138.1 Koti, Madhuri, 182.19 129.1 Kumari, Namita, 187.35 Knox, James, 51.5 Kolls, Jay, 139.7, 139.8, Kotla, Niranjan, 192.4 Krummel, Max, S17 Kumari, Swarnima, Ko, Eunju, 72.5, 75.20 181.7, 182.81, Kotsimbos, Tom, 74.12 Krupnick, Alexander S., 207.1 Ko, Eun-Ju, 140.9 191.16, 192.1 Kottilil, Shyam, 140.19 69.9 Kumirov, Vlad, 177.31 Ko, Hae Li, 196.25 Koltsova, Ekaterina, Kottyan, Leah, 197.11 Kryczek, Ilona, 137.11 Kundu, Soumya, Ko, M., 187.30 118.2, 191.12 Kouhi, Ali, 190.76 Krymskaya, Ludmila, 126.17 Ko, Mi-Ok, 117.22, Komatsu, Chiaki, 69.46 Koumpouras, Charles, 72.13 Kunimura, Kazufumi, 119.10, 187.31 Kominsky, Scott, 183.21 191.1 Krysa, Nicole, 191.18 55.11 Ko, Naomi, S162 Komiyama, Takuya, Koup, Richard, 72.6, Krzych, Urszula, 190.48 Kunisawa, Jun, 54.3 Ko, Rose, 193.9, 193.15 55.10 197.3 Ku, Cheng-Lung, Kunkel, Hannah, 197.25 Ko, Yi-An, 139.21 Komori, H., 53.4, 119.31 Koutsakos, Marios, 182.77 Kunning, Sheryl, 138.15 Ko, Young ji, 117.2 Koneru, Pratibha, 74.12 Kuan, Rebecca, 190.50 Kuns, Rachel, 69.38 Kobayashi, Daichi, 197.21 Kovacs, Krizstian, Kuang, Yi, 198.5 Kunster,¨ Axel, 178.3 177.26 Kong, Heidi, 58.12 121.10 Kubinak, Jason, 192.11 Kunz, Natalia, 125.5, Kobayashi, Katsunori, Kong, Ling-Yuan, Kovrigin, Evgenii, Kubo, Masato, 54.3 125.15 55.10 135.14 177.31 Kuchroo, Vijay, 124.14, Kuo, Ping-Chang, 165.1 Kobayashi, Koichi, Konjufca, Vjollca, 67.5, Kowal, Corinne, 120.32 137.15, S16 Kurashima, Yosuke, 190.31, 190.61 190.80, 196.9 Koyama, Motoko, 69.38 Kuczma, Michal, 52.5 54.3 Kobayashi, Koichi S., Konnikova, Liza, 67.12 Koylas, Nicholass, 55.20 Kudo, Eriko, 62.7 Kurd, Nadia, 60.14 64.20 Kono, Dwight, 132.5 Koylass, Nicholas, 184.1 Kuehn, Hyesun, 76.16 Kurella, Vinodh, 195.11

150 AUTHOR/SPEAKER INDEX

Kuroda, Marcelo, Lai, Jen-Feng, 195.32 Langille, Morgan, 192.4 Lawrence, Theodore, Lee, Jaewon, 117.2 126.23, 190.79 Lai, Laijun, 68.8, 116.3 Langlois, Ryan, 74.3 137.11 Lee, Jaewoong, 53.22 Kurosky, Alexander, Lai, Zhi-Wei, 115.6 Langsdorf, Chris, 57.21 Lawrence, Travis, Lee, Jea-Ik, 136.13 120.27, 120.28 Laidlaw, Elizabeth, Lanier, Lewis, 76.9, 115.22 Lee, Jeeho, 57.6, 67.3 Kurt, Robert, 135.9 182.88 129.8 Lawson, Dana, 197.21 Lee, Jeong-Mi, 70.6, Kuruc, JoAnn, 197.14 Laing, Bridie, 61.11, Lanka, Manasa, 134.1 Lawson, Louise, 139.16 195.15 Kutluay, Sebla, 197.21 61.19 Lannigan, Joanne, 69.9 Lawson, Mark, 58.6 Lee, Joey, 71.14 Kv, Santosh, 115.11 Laing, Steven, 133.3 Lanzavecchia, Antonio, Laxman, Bharathi, 67.22 Lee, Jong S., 190.55 Kvaratskhelia, Laino, Andressa, 194.21 133.2 Lay, Fang -Yun, 138.8 Lee, Josephine, 131.4, Mamuka, 197.21 Laiosa, Michael, S90 Lapinski, Philip, 125.14 Lazar, Dan, 52.19 131.13, 194.29 Kviatcovsky, Denise, Lajoie, Jason, 194.2 Laplante, Annie, 177.27 Lazarevic, Vanja, Lee, Josh, 186.1 190.79 Lake, Camille, 60.9, Lara, Sandra, 196.23 128.7, S158 Lee, Jounghyun, 128.18 Kvorjak, Michael, 71.18, 184.5 Larange, Alexandre, Lazarus, Robert, 132.4 Lee, Jun Sik, 58.7, 135.5 Lakhan, Ram, 53.10 67.18, 124.3, 140.4 Lazrak, Amina, 69.34 195.19 Kwak, Chaewon, 139.15 Lakhani, Baneen, 61.21 Larochelle, Andre, Le Campion, Armelle, Lee, Katharine, 129.1 Kwak, Hye Won, 196.25 Lakhdari, Omar, 126.4, 67.11 177.27 Lee, Kelvin, 118.15, Kwieraga, Amanda, 187.19, 190.43 Larochelle, Catherine, Le Friec, Gaelle, 125.5, 121.7, 123.11 184.6 Lakkis, Fadi, S33 181.8, 182.38, 182.66 125.15 Lee, Kun Ho, 182.85 Kwon, Bongjae, 125.9 Lakshmi, Bhavana, Larocque, Louise, Le Gall, Sylvie, 120.3 Lee, Kyoung-Hee, Kwon, Byungsuk, 63.13 139.13 Le Luduec, Jean- 64.20 190.55 Lakshmipathy, Uma, Larregina, Adriana, Benoˆıt, 76.3 Lee, Kyung-Mi, 56.21 Kwon, Ick chan, 117.2 130.33 54.5, 133.6 Le Page, Lauren, 73.23 Lee, Michael, 180.17 Kye, Yoon-Chul, 189.4 Laky, Karen, 67.15, Larsen, David, 134.8 Le, Catherine, 56.17, Lee, Mimi, 181.27 182.52 Larsen, Sasha, 139.5 69.36, 197.12 Lee, Renee, 185.15 Lalani, Almin, 58.9 Larson, Cameron, 75.7 Le, Khoa, 72.8 Lee, Sang-Myeong, L Lam, Brandon, 70.11, Larson, Erica, 190.36 Le, Thi Hong Nga, 56.22 La Gruta, Nicole, 60.7 196.21 Laskowitz, Daniel, 120.19 Lee, Sangsin, 122.7 La Porta, James, 186.16 Lam, Jonathan, 123.21 186.15 Leal, Joseph, 51.11 Lee, Seungeun, 53.16 Laageide, Leah, 115.9 Lam, Wing, 118.17 Lastrucci, Claire, 190.79 Leber, Andrew, 132.7 Lee, Sophia, 131.19 Labombarde, Jocelyn, Lamb, Tracey, 190.29 Latham, Leah, 190.75 Leblond, Marine, 194.3 Lee, Sung Kyun, 187.3 74.6 Lambert, Jeremy, Lathwal, Sushil, 69.1 Lebrilla, Carlito, 179.3 Lee, Sung-Eun, 192.18 LaBrie, Samuel, 52.21, 131.11 Lattanzio, Frank, 122.12 Lee, Peter P., 138.17, Lee, Won-Woo, 181.6 130.22, 131.26 Lamble, Adam, 195.10 Lau, Colleen, 76.9 138.21 Lee, Woojong, 70.5 Labuda, Jasmine, Lambracht-Washington, Lau, Joseph, 188.6 Lee Costich, Tara, Lee, Wyne, 132.4, 190.13 Doris, 70.3 Lau, Julia, 131.4, 194.29 138.22 133.3 Lacal, Juan Carlos, Lambris, John, 126.25 Laubach, Susan, 55.1 Lee, Adrian, 187.23 Lee, Ye Ji, 115.2 125.1 Lamens, Kristina, 198.2 Laucella, Susana, Lee, Andrew, 70.12, Lee, Yongjoon, 195.2 Lacey, Neal, 140.2 Lammert, Catherine, 190.60 134.7 Lee, Young-Tae, 139.18 LaCourse, Sylvia, 66.10 187.7 Laufer, Terri, 129.4 Lee, Brandon, 70.11, Lee, Yu-Na, 139.12 Laddy, Dominick, 139.3 Lampe, Anna, 139.14 Lauffenburger, 196.21 Lee-Kirsch, Min A., S41 Laderas, Ted, 195.10 Lampe, Kristin, 181.26 Douglas, 182.25 Lee, Chanju, 58.10 Leem, Galam, 136.13 Ladomersky, Erik, Lan, Jie, 75.12, 140.21 Lauing, Kristen, 137.2 Lee, Chong-Kil, 177.2, Lees, Christopher, 137.2 Lan, Joung-Liang, Laurent, Cyril, 182.38 177.3 69.10 Ladowski,Joseph,69.27 182.34 Laurent-Rolle, Maudry, Lee, Choong-eun, Leeth, Caroline, 116.12 Laffey, Kimberly, 195.24 Landon, Mark, 130.33 127.18 187.24 Leffler, Nancy, 120.21 LaFleur, Caitie, 182.22 Landuyt, Ashley, 192.20 Lauricella, Amanda, Lee, Darren, 192.17 Leger, Anthony, 120.26, Lafuse, William, 62.3 Lane, Clifford, 72.13, 135.9 Lee, Diane Da-Hyun, 190.54, 191.5 Lafyatis, Robert, 177.8 72.14 Lauron, Elvin, 177.23 128.9 Legewie, Larissa, Lagane, Bernard, Lane, Jerome, 134.1 Laurynenka, Viktoryia, Lee, Duck- Yeon, 56.10 126.6, 127.8 190.79 Lane, Thomas, 115.10, 197.11 Lee, Eun-Hyung, 50.10 Leggat, David, 190.45 Lahav, Boaz, 181.8 193.10 Lauver, Matthew, Lee, F. Eun-Hyung, Legge, Kevin, 139.11, Lahaye, Xavier, 75.11 Lang, Cara, 135.26 181.25, 197.15 123.20, 181.16 178.13 Lahiri, Aritraa, 191.14 Lang, Gillian, 196.19 Lauzon, Karoline, 73.13 Lee, Hong Kyung, Lehman, Michael, 67.11 Lahiri, Asha, 126.2 Lang, Ian, 62.15 Lavender, Paul, 125.5, 51.17, 134.20 Lehmann, Jason, Lahoud, Mireille, 196.27 Lang, Mark, 190.84 125.15 Lee, Howard, 189.15 130.24, 130.25, Lahti, Jill, 180.20 Lang, Xueting, 137.11 Lavoie, Brigitte, 192.5 Lee, Hyun Woong, 194.40 Lahue, Karrie, 192.5 Lange, Philip, 75.9 Lavoie, Jessie, 139.13 75.23 Lehrke, Michael, 53.17 Lai, Binbin, 186.3 Lange, Rachel, 188.18 Lawrence, Audrey, 68.4 Lee, Hyunji, 183.11 Lei, Ming, 134.16, Lai, Dengming, 122.4 Langella, Philippe, 66.2 Lawrence, Donald, Lee, Hyunsu, 180.6 194.33 Lai, Janice, 130.29, Langer, Harald, 126.25 127.9 Lee, Jae Geun, 120.8 Leite, Jefferson, 140.20 131.40 Langer, Robert, 126.37 Lawrence, Laurel, 74.1 Lee, Jae-Ung, 193.4 Lelliott, Patrick, 183.3

151 AUTHOR/SPEAKER INDEX

Lemaˆıtre, Florent, Li, Haibo, 69.17 Li, Yiming, 183.5 Lim, Seon-Ah, 56.21 Littman, Dan, 75.11 182.66 Li, Heng, 120.17 Li, Ying, 129.18 Lin, Chiao-Mei, 191.8 Littmann, Eric, 66.8 LeMar, Sara, 70.21 Li, Hongchuan, 59.11 Li, Yingqiu, 184.11 Lin, Chien-Wei, 115.20 Liu, Qinying, 185.2 Lemasson, Isabelle, Li, Hua, 127.11 Li, Yiwen, 69.41, 69.43, Lin, Chung Hao, 120.34 Liu, Baoyu, 115.18 75.16 Li, Jasmine, 196.27 70.8 Lin, Chun-Yen, 57.16, Liu, Cailian, 137.3 LeMessurier, Kim, 198.6 Li, Jiang, 120.22, 185.9 Li, Yong, 59.9 74.4 Liu, Changbao, 57.9 Lenardo, Michael, 52.14 Li, Jing, 127.1 Li, Yu, 60.20, 182.44 Lin, Dongdong, 194.16 Liu, Chao Lien, 120.34 Leng, Lin, 51.9 Li, Jinhui, 187.1, 187.2 Li, Yue, 190.27 Lin, Edwin, 120.31, Liu, Chengyu, 130.12 Lennard Richard, Mara, Li, Jiong, 52.10, 59.1, Li, Yuting, 54.5 182.83 Liu, Cherie, 196.1 181.3 117.9, 182.74 Li, Zheng-Rong, 74.1, Lin, Furong, 190.31 Liu, Chi, 117.12 Lenz, Laurel, 64.19 Li, Juan, 190.12 76.14 Lin, Jian-Da, 131.3 Liu, Chung Heng, 179.3 Leonard, Stephanie, Li, Jun, 115.1, 185.16 Li, Zhifeng, 182.82 Lin, Jianhong, 188.12 Liu, Dongyuan, 138.15 55.1 Li, Ju-Pi, 182.34 Li, Zhigang, 62.9 Lin, Jianxin, 54.13, Liu, Feng, S162 Leonard, Warren, Li, Kaito, 194.5 Li, Zhonghan, 185.1 115.12, 123.1 Liu, Fengjie, 64.7, 64.8 54.13, 115.12, 123.1 Li, Kun-Po, 194.2 Li, Zhong-Yin, 65.10 Lin, Jin Ping, 52.15 Liu, Fu-Tong, 183.1 Leonardi, Irina, 191.3 Li, Lei, 56.8 Li, Zihai, 57.12 Lin, Kou-I, 139.21 Liu, Haiyan, 69.7, 135.10 Leon-Ruiz, Beatriz, Li, Lichao, 180.6 Li, Zr, 66.17 Lin, Kuo-I, 185.8 Liu, Hong, 121.1 55.12, 56.18, 119.26 Li, Lingyun, 137.9 Liadi, Ivan, 134.2 Lin, Nina, 120.6 Liu, Hongna, 131.24 Lepsy, Chris, 130.36 Li, Lucy, 51.21 Liang, Jianguo, 197.19 Lin, Philania, S158 Liu, Hsin Yu, 76.17 Lesage, Sylvie, 118.11 Li, Manqing, 194.20 Liang, Jia-Qi, 184.11 Lin, Philiana, 139.3 Liu, Hua, 190.83 Lesinski, Gregory, 70.8 Li, Mei, 195.7 Liang, Shu, 65.3, 186.6 Lin, Pin-Hung, 196.15 Liu, Jianguo, 55.17 Lessard, Martin, 73.13, Li, Mei Mei, 67.21 Liang, Xiaoyan, 136.20 Lin, Qingshun, 183.16 Liu, Jianyun, 177.16 190.67 Li, Michael, 184.6 Liang, Yuejin, 75.4, Lin, Shili, 62.4 Liu, Jinbiao, 194.13 Leu, Yu-Wei, 64.21 Li, Min, 67.15 190.25, 190.37 Lin, Sijie, 195.3 Liu, Juan, 133.12 Leung, Charlotte, 188.4 Li, Minghong, 135.7 Liang, Yurong, 187.4 Lin, Tong-Jun, 127.11 Liu, Junhao, 195.6 Leung, Gabriel, 118.13 Li, Mingyang, 57.14 Liang, Zhuoyi, 123.18 Lin, Tsun-Mei, 127.5 Liu, Kaifeng, 69.13 Leung, Jacqueline, Li, Na, 133.10 Liao, Chu-Bin, 135.19 Lin, Wai, 62.8 Liu, Kebin, 194.8, 195.26 131.3 Li, Nan, 62.16 Liao, Fuyi, 69.21 Lin, Wan-Chi, 51.14 Liu, Li, 197.19 Leung, Jennifer, 63.3 Li, Nancy, 130.17, Liao, Jinfang, 130.28 Lin, Wan-Wan, 51.16 Liu, Longding, 120.17 Leung, Patrick, 179.3 134.16, 194.33 Liao, Kangsheng, Lin, Wei, 116.2 Liu, Lvyan, 194.18 Levack, Russell, 188.5, Li, Ning, 124.1 133.12 Lin, Wen-Hsuan, 198.8 Liu, Mei, 136.12 188.18 Li, Peng, 67.11, 123.1 Liao, Kuo Chen, 120.34 Lin, Xiaohe, 197.22 Liu, Meilian, 128.2 Leviatan Ben-Arye, Li, Pengfei, 181.3 Liao, Peng, 137.11 Lin, Xionghao, 187.35 Liu, Min, 192.7 Shani, 70.14 Li, Qingtian, 51.1 Liao, Wei, 183.2 Lin, Xun, 181.7, 181.11 Liu, Mingyong, 195.7 Levin, Michael, 182.61 Li, Quan_Zhen, 74.6, Liao, Yang, 125.18 Lin, Yi-Ting, 117.12 Liu, Peter, 190.25 Levine, Alan, 56.12, 120.9 Liao, Yi-Chu, 191.8 Lin, Yujun, 68.8, 116.3 Liu,Qing,115.13,194.11 60.8 Li, Quanzhen, 69.30 Libby, Stephen, 64.18 Lind, Evan, 120.12, Liu, Queping, 118.12 Levine, Mark, 133.11 Li, Rong, 195.16, Libermann, Towia, 187.29, 195.10 Liu, Rebecca, 137.11 Levitin, Hanna, 60.5 195.17, 195.29 182.17 Lindenberg, Valesca, Liu, Shanrun, 179.5, Levy, Michael, 194.41 Li, Shanping, 126.7 Liby, Karen, 135.17 126.18 179.10 Lewinsohn, David, Li, Shuai, 134.13 Lichte, Jens, 126.18 Lindestam Arlehamn, Liu, Sheng, 55.3 190.50 Li, Shulin, 135.14 Lichti, Cheryl, 180.5 Cecilia, 120.20, Liu, Shirley, 133.7 Lewis, Carlessia, 74.6 Li, Song, 131.24 Licona-Limon, Paula, 190.50, 190.78 Liu, Susan, 183.15 Lewis, Gavin, 122.10 Li, Stephen, 131.2 118.18 Lindforss, Ulrik, 65.6 Liu, Tianju, 182.3 Lewis, Josh, 115.6 Li, Tiantian, 56.4, 190.16 Lied, Alexandra, 120.3 Lindsey, J William, 193.2 Liu, Xia, 137.9 Lewis, Kathryn, 138.1 Li, Ting, 133.12 Lifson, Jeffrey, 72.6 Lindskog, Elinor, 138.13 Liu, Xiao, 182.74 Ley, Ariel, 123.20 Li, Tong, 72.13 Lifson, Jeffrey D., 72.13 Lindstedt, Anders, 52.19 Liu, Xiaomei, 197.17 Ley, Klaus, 182.1 Li, Wei, 66.19, 75.12, Ligeiro, Dario,´ 57.2 Linehan, Melissa, Liu, Xiaowei, 70.22 Li, Jin-fen, 51.15 115.7, 132.6, 140.21 Liggitt, Denny, 64.18 194.28 Liu, Xin, 62.1, 195.1 Li, Tiger, 192.16 Li, Weidang, 196.17 Lightman, Shivana, Lingwood, Daniel, Liu, Yuen-Joyce, 64.20 Li, Ailin, 136.11 Li, Wen, 197.21 121.7 139.22 Liu, Yun-Cai, 57.6, 67.3, Li, Bing, 69.46 Li, Wenjuan, 72.8, Liley, Helen, 187.12 Link, Verena, 187.21 188.14 Li, Changgui, 139.13 139.25 Liligeto, Urijah, 130.34, Lio, Chan-Wang, 123.15 Liu, Yusen, 187.1, 187.2 Li, Chaofan, 60.2 Li, Xiang, 65.14 130.37, 182.80 Lionakis, Michail, 128.7, Liu, Yuying, 193.2 Li, Chuanyou, 190.65 Li, Xiao-Nan, 194.41 Lillard, James, 52.8, 190.4 Liu, Zhaoping, 131.7 Li, Chunmei, 193.7 Li, Xiao-qing, 68.17 181.13, 181.14, Lipke, Peter, 126.11 Liu, Zhonghua, 63.9 Li, Dan, 188.10 Li, Xiaoxia, 192.3 181.17, 194.36 Lipscomb, Jonathan, Liu, Zhongshan, 138.18 Li, Gaopeng, 137.11 Li, Xin, 191.3 Lim, Min Hui, 138.17, 51.15 Liu, Zirui, 55.14 Li, Guangming, 71.20, Li, Xuguang, 139.10 138.21 Lira, George, 136.10 Liu-Bryan, Ru, 125.1 75.1 Li, Yan, 182.14 Lim, Ji-Young, 192.18 Little, Alexander, 65.12 Lizano, Marcela, 196.26 Li, Guangqiang, 60.10 Li, Yihang, 73.11 Lim, Sangho, 193.4 Little, Amie, 189.14 Llorens, Braulio, 56.12

152 AUTHOR/SPEAKER INDEX

Lloyd, Jessica, 60.12 Lopez, Rafael, 190.14 Lukacher, Aron, 181.25, Ma, Congrong, 192.10 Magod, Prerna, 135.23 Lo Conte, Marta, 178.8 Lopez, Raphael, 190.9 197.15 Ma, David, 69.8 Magoffin, Wyatt, 196.16 Lo Verso, Luca, 73.13 Lopez-Ortega,´ Orestes, Lukens, John, 187.7 Ma, Dennis, 135.4 Maguire, Cole, 193.5 Lo, Richard, 122.10 51.3 Luker, Andrea, 119.7 Ma, Jasmin, 182.24 Mahajan, Swapnil, Lo, Tzu-Han, 183.1 Lorenzo, Melvin, 67.7 Luker, Jennifer, 196.28 Ma, Jiadai, 117.25, 130.20, 131.16, Lobby, Jenna, 66.17, Loschwitz, Jennifer, Lukin, Kara, 61.10 187.36 131.20, 131.27 74.1 127.8 Lulo, James, 195.11 Ma, Jianping, 75.1 Mahata, Sushil, 117.5 Lobby, Jenny, 129.2 Loter, Lorraine, 194.38 Lumaquin, Dianne, 76.3 Ma, Jing, 178.18 Mahe, Perrine, 50.12 Lobritto, Steve Lobritto, Lott, Nathaniel, 184.5 Lumbard, Keith, 182.88 Ma, Jinxia, 52.13 Mahendra, Ankit, 134.2 182.39 Lotze, Michael, 187.23 Luna, Evelyn, 196.11 Ma, Kaiwen, 122.12 Mahesh, Seema, 119.2 Locker, Kathryn, Louahem, Djamel, 50.12 Lund, Frances, 51.10 Ma, Lina, 69.21 Mahgoub, Bayan, 69.9 181.26, 182.28 Loudovaris, Thomas, Lund,Jennifer,57.8,S25 Ma, Royce, 71.8 Mahmood, Arslan, Locksley, Richard M., 74.12 Lund, Sean, 187.19, Ma, Shengyun, 125.20 182.82 S141 Louis-Plence, Pascale, 190.43 Ma, Shoubao, 69.24, Mahoney, Katheleen, Lococo, Bruno, 190.60 50.12 Lundberg, Cathryn, 69.25 195.31 Lodi, Alessia, 125.1 Lounsbury,Nicolas,59.6 136.2 Ma, Weiwei, 71.20 Mai, Xuyen, 187.15 Lodoen, Melissa, 190.6 Love, James, 128.20 Lundborg, Luke, 67.13 Ma, Wenji, 129.8 Maiello, Pauline, 139.3, Loewendorf, Andrea, Lovell, Gillan, 130.30 Luo, Bao, 115.1, 179.5 Ma, Yussanne, 194.41 190.3, 190.36 182.64 Low, Jun Siong, 129.9 Luo, Claire, 125.20 Maassen, Sjors, 177.7 Maier, Lisa, 182.68 Loffredo, Stefania, Low, Quentin, 130.16 Luo, Jaidi, 182.31 Maazi, Hadi, 122.10 Mailard, Ivan, 69.42 126.16 Lowen, Anice, 76.14 Luo, Jing, 132.16 Macadangdang, Maillard, Ivan, 69.10 Logandha Lownik, Joseph, 119.7 Luo, Mei, 51.1 Benjamin, 192.10 Mailliard, Robbie, 76.8 Ramamoorthy Lu, Yan, 130.17, 134.16 Luo, Meng, 193.2 MacDonald, Cameron, Majidi, Shabnam, 137.7 Premlal, Ashmitaa, Lu, Cheng-You, 133.14 Luo, Xiaoyu, 197.2 195.23 Majonis, Daniel, 131.2 65.3, 70.16 Lu, Chunwan, 194.8, Luo, Xin, 178.10, 178.11 MacDonald, Kelli, 69.42 Major, Amy, 116.14, Lohmueller, Jason, 195.26 Luo, Xunrong, S33 Mace, Emily, 62.21 182.59 136.17 Lu, Hongxiang, 135.11 Luo, Yang, 116.1, 133.1 Macedo,ˆ Bruna, 140.20 Majumder, Parimal, Loke, P’ng, 131.3 Lu, Li-Fan, 134.3 Luo, Yiliao, 195.6 Machado, Yoan, 70.23 60.13 Lolis, Elias, 51.9 Lu, Peiyuan, 60.13 Luo, Zhengkang, 182.53 Mack, Douglas, 182.68 Mak, Tak, 117.17 Lomas, Woodrow, Lu, Ran, 50.4 Luo, Zhenkan, 182.47 Mack, Matthias, 198.4 Makaryan, Sahak, 64.27 131.35 Lu, Shiping, 182.81 Luo, Zhenwu, 120.1 Mackay, Laura, 138.2 Makedonas, George, Lombaba, Noelle, Lu, William, 136.17 Luong, Nhungoc, 75.2 Mackel, Joseph, 190.8 182.15, 194.17 131.19 Lu, Wuyuan, 66.5 Luthers, Christopher, MacKenzie, Tippi, Makhov, Petr, 118.2 Lomueller, Jason, 71.18 Lu, Xiaofan, 197.19 184.5 129.3 Malaer, Joseph, 134.12 Londei, Marco, 196.1 Lu, Xiaoxiao, 53.1 Lutz, Cathleen, 130.10, Mackey, Emily, 54.2, Maleche-Obimbo, Londregan, Jennifer, Lu, Xinping, 183.21 132.14 54.15 Elizabeth, 66.10 138.11 Lu, Yih-Kaung, 177.32 Luu, Hanh, 119.9 Macleod, Bethany, Maleri, Seth, 195.31 Long, Alan, 70.12, Lu, Ying, 183.13 Luus, Lia, 195.11 197.10 Malherbe, Delphine, 134.7, 195.21 Lu, Zhen, 194.18 Luzina, Irina, 132.3 MacNabb, Brendan, 72.9 Long, Andrew, 196.1 Lu, Zhongyan, 72.4 Luznik, Leonard, 69.42 135.6, 135.21 Malhotra, Anil, 121.6 Long, Eric, 76.16, Lu, Ziyang, 69.44 Lv, Jiyang, 182.73 Maddaloni, Massimo, Mali, Venkat, 133.7 134.5, 177.24, 187.9 Lubinsky, Cody, 132.9 Ly, Quan, 135.15 196.2 Malik, Brian, 138.1 Long, Sarah, 180.11 Lucar, Olivier, 76.4 Lyadova, Irina, 120.18 Madden, Matthew, Mallal, Simon, 140.14 Longhi, Maria Serena, Lucas, Anna, 69.35 Lynch, Nicholas, 137.10 Mallappa, Mahesh, 68.13, 182.10, 182.43 Lucas, Sasha, 75.11 182.54 Madenspacher, 119.2 Longnecker, Richard, Lucendo, Alfredo, Lynch, Susan, 191.17 Jennifer, 51.14 Mallarpu, Chandra 140.3 120.31 Lyons, David, 133.15 Madi, Asaf, 124.14, Shekar, 120.13 Longo, Valter, S168 Lucero-Diaz, Pedro Lyons, Jeri-Anne, 137.15 Mallick, Amirul, 191.14 Lonnberg, Tapio, 186.1 Alejandro, 68.10, 193.16 Madiraju, Charitha, Mallon, Francine, 68.4, Loo, Chin San, 128.1 70.17, 131.17 Lyons, Jesse, 71.10, 120.13 195.28 Lood, Christian, 63.12 Luciani, Fabio, 74.12 136.20 Madrigal, Ariel, 125.4, Malloy, Allison, S101 Loots, Gabriela, 118.16 Ludescher, Melissa, Lyons-Cohen, Miranda, 131.18, 182.27, 186.6 Malmberg, Karl- Lopes, Mikayla, 71.1, 195.24 51.14, 117.1 Madugula, Kiran, 75.16 Johann, S160 130.1 Ludwig, Anika, 197.25 Lyu, Jun, 188.10 Maehara, Akie, 54.8 Malo, Courtney, 76.15, Lopez Moyado, Issac, Ludwig, Janos, 198.12 Lyu, Shu-Chen, 196.1 Mage, Michael, 177.15 126.5 134.3 Lugo, Geanncarlo, Magilnick, Nathaniel, Malo, Kirsten, 70.4 Lopez, Carolina, 196.14 190.79 53.22 Malone, Dane, 194.20 Lopez, Charlie, 64.5 Lugo-Villarino, M Magnusen, Albert, Maloney, Nicole, 192.8 Lopez, Diego, 53.15, Geanncarlo, 66.2 Ma, Caixia, 192.3 181.9 Malur, Anagha, 120.21, 118.1 Lui, Wai Yin, 127.6 Ma, Che, 139.21 Magnuson, Michael, 187.20 Lopez, Genghis, 187.12 Luka, Marine, 75.11 Ma, Chunyan, 191.15 133.13 Malysa, Agnes, 195.30

153 AUTHOR/SPEAKER INDEX

Mammadova, Vafa, Marcella, Simone, Martin, Rebecca, 119.7, Mathews, Clayton, McBride, Andrew, 182.5 126.16 136.21 115.16 198.11 Mamonkin, Maksim, Marches, Radu, 117.19 Martinez Becerra, Mathews, Lisa, 69.28, McBride, Heidi, 177.27 71.8 Marcovecchio, Paola, Francisco, 131.22 69.35 McCall, Jamie, 186.14 Man, Kwan, 195.13 182.1 Martinez, Britney, Mathy, Nicholas, McCann, Taylor, 118.13 Man, Si Ming, 63.10 Marcucci, Guido, 53.22 197.23 190.12, 190.83 McCarthy, Claire, Manafi, Amir, 69.9 Marcus, Robert, 131.15 Martinez, Danielle, Matias, Fernando, 195.30 Managlia, Elizabeth, Marcus, Sarah, 117.13, 126.20 191.18 Mccauley, Caroline, 192.14 190.40 Martinez, Gustavo, Matiski, Lawrence, 131.3 Manago’,Antonella,52.2 Margolis, David, 197.14 189.5 70.22 McCauley, James, Manakkat Vijay, Margulies, David, Martinez, Ivan, 186.14 Matissek, Stephan, 139.9 Godhev, 188.19 177.15, 177.31 Martinez, Jennifer, 64.14, 194.35 McCaw, Tyler, 195.7 Mandal, Gunjan, 135.25 Mariani,Thomas,139.24 S200 Matkins, Victoria, 118.14 McCloud, Rebecca, Mandalakas, Anna, Maricic, Igor, 57.10, Martinez, Mercedes, Matsubara, Keisuke, 71.7 62.21, 194.17 132.5 182.39 116.7 McClune, Madison, Mandikian, Danielle, Maridonneau-Parini, Martinez, Osvaldo, Matsubara, Toshiyuki, 56.6 131.19 Isabelle, 190.79 196.8, 197.25 130.32 McClure, Keaton, 73.21 Mandoiu, Ion, 70.13 Marinelli, Michael, 66.11 Martinez-Fernandez, Matsumoto, Masrissa, McConville, Malcolm, Manel, Nicolas, 75.11 Mariño, Alejandro, Diana, 135.24, 131.19 60.7, 189.1 Manfredi, Mark, 137.3 126.26 182.40 Matsumura, Fumio, 51.2 McCoy, Laura, 72.8 Mangalam, Ashutosh, Maris, John, 130.4 Martinez-Paniagua, Matsunaga, Yasuka, McCue, Shaylene, 178.13, 178.14 Markert, Mary, 182.32 Melisa, 134.2, 134.6 192.1 53.17, 56.15, 68.16, Mangani, Davide, Markiewicz, Mary, Martini, Sheridan, Mattapallil, Mary, 116.6, 135.8 137.15 115.16 131.20 120.26, 190.54 McCullough, Peter, Manguso, Robert, 58.17 Markiewski, Maciej, Martinon, Daisy, 187.17 Matthews, Helen, 52.14 136.16 Manhas, Kavita, 66.6 S100 Martyanov, Viktor, Mattila, Joshua, 62.2, McDaniel Mims, Manick, Brian, 124.4 Markman, Janet, 120.4 182.37 62.19, 182.86, 190.2 Brianyell, 69.22 Manilay, Jennifer, 65.5, Markovics, Adrienn, Marubayashi, Sachie, Mattila, Pieta, 177.12 McDaniel, Brianyell, 118.16, 188.16 133.4 119.5 Mattoo, Abid, 70.1 69.3 Manjili, Masoud, 194.7 Marks, Kathryne, 115.19 Maruyama, Sandra, Matus Nicodemos, McDaniel, Jonathan, Manlove, Luke, 194.6 Marquardt, Kristi, 50.5, 190.22 Rodrigo, 197.3 71.15 Mann, Lovepreet, 140.8, 180.2 Marvin, Jennifer, 182.59 Matute-Briseno, Jose McDermott, Adrian, 62.14, 120.10 Marquez-Lago, Mascola, John, 72.6 Antonio, 68.10, 70.17, 72.11, 190.45 Manna, Alak, 71.12, Tatiana, 119.26 Maslanka, Jeff, 138.11 131.17 McDermott, Meghan, 71.13 Marquez-Manriquez, Maslanka, Tomasz, 68.2 Matyjaszewski, 136.16 Mannering, Stuart, Juan, 68.10, 70.17, Maslanka,´ Tomasz, Krzysztof, 69.1 McDonald, Christine, 74.12 131.17 73.10 Maude, Shannon, S107 127.7 Manni, Michelle, 198.10 Marra, Marco, 194.41 Mason, Andrew, 182.39 Mauler, Maximilian, McDonald, David, 52.14 Mannie, Mark, 193.3 Marrero, Idania, 57.10, Masopust, David, 126.25 McDonald, Keely, Manno, Emma, 72.11 132.5 66.21, 189.9, 194.6 Maulloo, Chitavi, 196.20 129.17, 181.28 Mansfield, Jim, 130.7 Marrs, Aubrey, 194.2 Masri, Joumana, 181.4 Mauner, Aaron, 182.4 McFadden, Geoffrey, Mansour, Michael, Marrs, Samuel, 194.29 Massarotti, Elena, 182.8 Mauvais, François- 196.27 70.19, 127.22 Marsh, Henry, 136.4 Massilamany, Xavier, 177.22 McGargill, Maureen Mantero, Julio, 182.49 Marshak Rothstein, Chandirasegaran, Mawe, Gary, 192.5 Ann, 74.6 Mantis, Nicholas, 66.25 Ann, 136.16 115.3, 180.19 Maximova, Anna, 72.6 McGavern, Dorian, Manuchehrabadi, Marshak-Rothstein, Massion, Pierre, 138.7 Maxwell, Tyler, 75.21 140.2 Navid, 194.31 Ann, 179.12 Masteller, Emma, 70.4 Maynard, Craig, 192.20 McGeachy, Mandy, Manzi, Susan, 182.8 Marshall, Jean, 69.45 Master, Alyssa, 131.22 Maz, Mitra, 124.8 S16 Mao, Kairui, 124.13, Marshall, Lisa, 119.5 Mastio, Jerome, 137.4 Mazahery, Claire, 60.8 McGettigan, Shannon, 188.10 Marshall, Michaela, Mastorakos, George, Mazgaeen, Lalita, 127.3 129.5 Mao, Xianrong, 64.1 190.4 187.9 Mazzola, Francesca, McGill, Jodi, 73.16, Maphalala, Gugu, Marshall, Pamela, 66.6 Masuda, Kazuya, 195.3 52.2 73.18 62.21, 194.17 Marson, Alexander, Mata, Carlos, 52.14 Mazzurana, Luca, 65.6, McGill, Jodi L., S32 Maradiaga, Nidia, 54.2 124.9, 130.6 Matalon, Sadis, 55.15, 187.10 McGill, Mahalia, 50.3 Maravillas-Montero, Martens, Gregory, 69.27 119.26 Mboko, Wadzanai, McGovern, Karen, 137.3 Jose,´ 51.3 Martin, Aaron, 68.14 Matemo, Daniel, 66.10 139.17 McGowan, Jenna, 182.6 Maravillas-Montero, Martin, Allison, 182.68 Matheoud, Diana, McAnarney, Eileen, McGraw, Joseph, 194.1 Jose´ Luis, 118.18, Martin, Ian, 66.22 177.27 197.9 Mcguire, Kathleen, 179.7, 179.8, 190.81 Martin, Maureen, 120.3 Mathers, Alicia, 125.3 McArdle, Andrew, 195.31 Marcelain, Katherine, Martin, Patricia, 190.6 Mathew, Porunelloor, 182.61 McGuirk, Paul, 186.8 177.1 Martin, Paul J., 69.11 134.12 McArdle, Sara, 67.8 McHugh, Kevin, 66.11

154 AUTHOR/SPEAKER INDEX

McIntyre, Laura, 135.4, Meikle, Claire, 194.10 Mi, Qing-Sheng, 118.12 Min, Hyungyu, 123.12 Modestino, Luca, 126.16 193.10 Meiler, Svenja, 130.27 Mi, Tian, 50.10, 123.8, Minazzato, Gabriele, Modis, Yorgo, 52.14 McIntyre, Tina, S152 Meininger, Cynthia, 188.2 52.2 Modlin, Robert, 58.13, McKarns, Susan, S90 54.10 Miaw, Shi-Chuen, Minchinton, Robyn, 120.25 McKay, Mary, 181.9 Meisler, Adam, 194.10 117.12 187.12 Modrak, Samantha, McKee, Amy, 182.68 Meissner,Torsten,64.20 Michael A, Thomas, Mine, Jessica, 138.22, 65.12, 134.10 McKee, Krisha, 72.6 Melamed, Esther, 193.5 72.1 194.2 Moeser, Adam, 54.2, McKenna, Kyle, 136.16 Melchinger, Wolfgang, Michaux, Justine, 70.13 Minn, Andy, 134.4 54.15, 73.11, S32 McKenna, Mary, 71.8 69.10 Michell, Danielle, Minning, Todd, 190.60 Moeser, Matthew, McKillop, William, 71.11 Mellins, Elizabeth, 116.14 Minter, Ross, 52.1, 197.14 McKinstry, Karl, 66.13, 188.11 Michelsen, Kathrin, 181.10 Mohamed, Attia, 61.8 66.19, 122.8 Mellor, Andrew, 179.9 129.6 Miorin, Lisa, 127.18 Mohamed, Yassir, 50.16 McLaughlin, Erin, 55.12 Melo, Mariane, 121.9 Mielcarska, Matylda, Miozzo, Pietro, 128.6 Mohammad, Tabrez, McLaughlin, Taryn, Melo, Paulo, 185.14 64.11 Miranda, Kathryn, 195.29 190.39 Menachery, Vineet, Mifsud, Nicole, 74.12 183.4, 185.6 Mohammadpour, Hemn, McLellan, Jason, 139.11 197.9 Migliore, Frank, 133.16 Miranda, Nadia, 52.18 136.27, 195.23 Mcleod, Cara, 133.16 Menager,´ Mickael,¨ 75.11 Mihindukulasooriya, Miranda-Katz, Margot, Mohammed, Ahmed, McMahon,Jeffrey,133.7 Mendes, Muriel, 131.11 S.P., 187.30, 187.31 198.10 192.11 McManus, Daniel, 75.18 Mendez, Jenny, 136.3, Mihindukulasooriya, Mirchia, Kanish, 180.1 Mohammed, Amira, McManus, Daniel, 56.19 136.15 Suyama, 117.22, Mirkin, Chad, 70.12, 67.10 McNagny, Kelly, 55.7, Mendiola, Carolina, 119.10 134.7 Mohammed, Zahraa, 58.3 118.18 Mikecz, Katalin, 133.4 Miron, Michelle, 60.5 54.7 McNally, Jonathan, Mendonca, Stacee, Miki, Haruka, 119.20 Mirpuri, Julie, 66.4 Mohan, Arjun, 120.21 122.16 197.7 Mikkelsen, Jacob, 66.12 Mirsepasi-Lauridsen, Mohanty, Subhasis, McNamee, Eoin, 182.4 Mendoza, Ryan, 54.14 Mikkelsen, Tarjei, Hengameh, 192.3 181.22 McNerney, Kevin, Mendoza, Ventura, 131.4, 131.13, 194.29 Mirza, Meral, 193.12 Mohler, Kailey, 193.5 134.17 124.9, 191.17 Miklos, David, 69.42 Mishina, Margarita, Mohn, William, 55.7 McPeek, Matthew, Mendy, Angelico, 66.11 Mikulin, Joseph, 126.29 139.17 Moioffer, Steven, 198.7 187.20 Meng, Fengzhen, Mikulski, Zbigniew, Mishra, Amarjit, 55.16 Molin, Magnus, 130.35 McShan, Andrew, 194.13 182.1, 191.11 Mishra, Manoj, 181.13 Moliva,Juan,62.3,62.20 177.31 Mengozzi, Giulio, 52.2 Milbrandt, Jeffrey, 64.1 Mishra, Rabi, 74.7 Mollard, Vanessa, McSorley, Stephen, Menikou, Stephanie, Milcarek, Christine, Miskov- Zivanov, 196.27 190.13 182.61 123.9 Natasa, 135.5 Molleken,¨ Katja, 126.18 McVicker, Graham, Menk, Ashley, 122.3 Miles, Darryl, 182.55 Miskov-Zivanov, Molodtsov, Aleksey, 131.18, 182.27 Menon, Ashwathi, 70.7 Millan, Alberto, 65.5 Natasa, 71.18 138.1 McWeeney, Shannon, Menon, Hari, 136.11, Miller, Aaron, 134.1 Mistri, Somen, 53.21, Molofsky, Anna Victoria, 195.10 177.32 Miller, Brian, 58.17 65.13 S201, 129.1 McWilliams, Jennifer, Menoret, Antoine, Miller, Jacqueline, 182.1 Mistry, Sejal, 130.23 Molony, Ryan, 62.7 52.1 63.14, 126.36 Miller, Jeffrey, 136.22 Mitchell, Angela, 182.57 Moltke, Jacob, S141 Meador, Lydia, 177.32 Mentzer, Alexander, Miller, Jessica, 182.19 Mitra, Ramkrishna, Momen-Heravi, Mealey, Robert, 73.20 196.12 Miller, Joseph, 120.22 181.15 Fatemeh, 195.33 Meaney, Connor, 178.9 Merchand-Reyes, Miller, Louis, 190.7 Mittal, Aarti, 120.22 Monaghan, Kelly, Mechler, Claire, 190.9, Giovanna, 59.12 Miller, Marcia, 73.8, Mittal, Suresh, 139.17 115.12 190.14 Merghoub, Taha, 177.6 Mittelstadt, Paul, 53.12 Monaghan, Sean, 62.10 Medeiros, Alexandra, 134.13, 136.23, 137.3 Miller, Maxine, 69.46 Mittelsteadt, Kristen, Mongini, Patricia, 182.62 183.17 Merica, Rebecca, Miller, Michelle, 135.5, 128.4 Monhanakumar, Medin, Jeffrey, 71.11 182.50 136.17 Miyadera, Hiroko, Thalachallour, S33 Medina Contreras, Merly, Liza, 73.4 Miller, Mindy, 67.9 177.10 Monlish, Darlene, 118.3 Oscar, 118.18 Meskas, Justin, 131.41 Miller, Stephen, 68.5 Miyairi, Satoshi, 69.14 Montague, Justin, Medina, Carlos, 52.15, Messing, Melina, 58.3 Mills, Cole, 182.22 Miyajima, Michio, 56.2 195.25 119.14 Messmer, Michelle, 58.2 Mills, Devin, 182.58 Miyashin, Michiyo, 55.10 Montealegre, Medina, Kay, 53.20 Metelitsa, Leonid, Mills, Kathleen, 67.22 Miyazaki, Toru, 123.3 Sebastian, 177.5 Mehrkens, Brittney, 195.27 Mills, Kingston, 125.11 Mizes, Alicia, 59.10 Montecalvo, Angela, 190.34 Metidji, Amina, 51.4 Mills, Steven, 60.20 Mizgerd, Joseph, 51.14, 184.1 Mehrotra,Shikhar, 137.5 Metten, Madeline, 67.19 Milner, J., 60.14, 138.6 66.22, 198.14 Montecino-Rodriguez, Mehrpouya-Bahrami, Meuth, Sven, 126.25 Milner, J. Justin, 189.12 Mjosberg,¨ Jenny, 65.6, Encarnacion, 118.10 Pegah, 69.6, 185.6 Meyer, Everett, 52.15 Mimche, Patrice, 190.29 187.10 Monteiro, Freddy, 64.1 Mehta, Monika, 189.6 Meyer-Hermann, Min, Booki, 119.12, Mo, Feiyan, 71.8 Monterio, Clarice, 67.4 Mehta, Satish, 182.15 Michael, 196.22 120.19 Mo, Sasa, 181.20 Montero, Leslie, 134.1 Mei, Congjin, 181.20 Meyerholz, David, 198.4 Min, Chang-Ki, 192.18 Mo, Yufei, 75.22 Montesclaros, Luz, Mei, Linda, 53.21 Mhatre, Siddhita, 182.13 Min, Daeun, 58.10 Mockus, Taryn, 181.25 131.4, 194.29

155 AUTHOR/SPEAKER INDEX

Montgomery, Courtney, Morris, Venetia, 67.8 Mudalagiriyappa, Murooka, Thomas, Nair, Meera, 120.22, 178.15 Morrison, Holly, 129.11, Srinivasu, 190.17 190.21 185.9, 190.15, S169 Montgomery, Ruth, 182.30 Mueller, Ernie, 131.12 Murphy, Anne, 125.1 Nair, Smita, 136.9 181.22 Morrison, Juliet, 127.18 Mueller, Kevin, 116.9 Murphy, Joanne, 184.1 Nair, Vinod, 139.20 Montgomery, Theresa, Morrison, Sherie, Mueller, Scott, 138.2 Murphy, Kenneth, Nakamoto, Margaret, 178.3 118.10 Muenzer, Patrick, 177.23, 177.33 131.40, 189.18 Montoya, Leticia, 130.16 Morrissey, Philip, 131.5 126.25 Murphy, Sarah, 189.14 Nakanishi, Yukihiro, Montoya, Maria, 62.4 Morrissy, Sorana, Mufazalov, Ilgiz, 181.4 Murphy, William, 56.17, 139.16 Moogk, Duane, 194.5 194.41 Muhammad, Fauziyya, 69.36, 126.27, 197.12 Nakano, Hideki, 51.14, Moon, Eun Yi, 117.8 Morrocchi, Elena, 72.11 192.17 Murra, Alexandra, 117.1, 119.18, 119.23 Moon, James, 119.14, Morse, Christina, 177.8 Mukai, Kaori, 126.2 178.14 Nakayama, Hideorshi, 119.25 Morse, Herbert, 123.1 Mukerjee, Ananda, Murray, Clare, 195.29 130.32 Moon, Jun-Hyeok, 177.3 Mortimer, Stefanie, 64.23 Murray, Gina, 187.20 Nakayama, Toshinori, Moon,Sol,124.6,124.11 60.19, 131.35, 131.40 Mukherjee, Neelam, Murre, Cornelius, 54.3, 177.26 Moore, Eugene, 140.14 Moseman, E. Ashley, 136.14 60.11, 125.6 Nakhasi, Hira, 196.29 Moore, Ian N, 178.2 66.7 Mukherjee, Samiran, Murrell, Ben, 72.8 Nallapothula, Dhiraj, Moore, Rashida, 190.78 Moses, Stephanie, 68.13, 182.10 Murrell, Benjamin, 182.73 Moore, Richard, 194.41 179.12 Mukhopadhaya, 197.20 Nam, Jae-Hwan, 196.25 Moorman, Cody, 193.3 Moshayedi, Aref, Arunika, 127.14, Murrray, Annie, 190.24 Namen, Shelby, 56.20 Mora, Conchi, 180.20 129.13 190.35 Murthy, Ashlesh, 196.17 Nanaware, Padma, Morais, Rayanne, Moskovljevic, Milica, Mukhopadhyay, Murthy, Supriya, 59.5 177.9, 177.21 136.10 177.18 Pamela, 69.38 Muschen, Markus, 53.22 Nanjappa, Moran, Gabriel, 73.19 Moss, Alan, 68.13, Mukhopadhyay, Mushtaq, Zuena, 72.2, Somashekarappa, Moran, Michael, 76.7 182.10 Sangita, 190.57 72.3, 197.1 190.17 Moraña, Eduardo, Mossamaparast, Nima, Mukthavaram, Rajesh, Musial, Shawn, 53.21 Naqvi, Kubra, 127.17 190.79 177.23 194.22 Musunuri, Tarakarama, Naqvi, Nilofer, 120.7 Morandini, Ana Mosure, Sarah, 68.6 Mukundan, Santhosh, 196.17 Naradikian, Martin, Carolina, 185.15 Motamedi, Melika, 120.30 Muzzio, Damian, 123.19 134.1 Morawski, Peter, 51.7 76.18 Muller, Yannick, 133.2 Myers, Jay, 51.21 Narain, Sonali, 182.8 Morcavallo, Alaide, Motley, Samantha, 51.7 Mullins, Genevieve, Myers, Sheldon, 196.16 Narang, Neha, 196.7 194.41 Motta, Vinicius, 136.24 115.17, 115.22 Myers, Timothy, 190.78 Narasimhan, Balaji, Moreau, Joshua, 71.11 Motu, Lakin, 61.19 Mullins, James, 72.4 139.11 Morel, Laurence, 66.19, Mou, Zhirong, 190.21 Munawara, Usma, Narasipura, Srinivas, 115.7, 116.4, 132.6, Mouchess, Maria, 132.4 126.34 N 117.10 132.12, 178.12, S200 Mountz, John, 115.1, Mundhenke, Tiffany, Na, Hye Young, 118.4, Narayanan, Bitha, Morel, Penelope, 179.5, 179.10 190.73 119.24, 177.4, 177.13 186.16 115.21, 128.16 Mousa, Jarrod, 198.1 Mungall, Andrew, Nadeau, Kari, 119.1, Nardozzi, Jonathan, Morelli, Adrian, 133.6 Moussa, Maha, 72.13 194.41 119.14, 196.1 71.10 Morenikeji, Olanrewaju, Moustaki, Ardiana, Muniz, Maria, 195.30 Nadella, Vinod, 58.12 Narsale, Aditi, 182.24 73.17 134.14 Munkarah, Adnan, Nadig, Satish, 137.5 Narvaez-Miranda, Moreno, Javier, 139.7, Moutsopoulos, Niki, 135.30 Nadler, Jerry, 122.12 Janiret, 186.9 139.8 S169 Munn, David, 69.10 Nag, Mukta, 76.11 Nasarre, Cecile, 187.23 Morey, Alison, 60.11 Mowa, Nathan, 190.85 Muñoz Valle, Jose Nagai, Hideaki, 177.10 Nascimento, Amanda, Morgan, Roxroy, 65.2 Mowen, Kerri, 140.8 Francisco, 135.24 Nagai, Shigenori, 55.10 119.30 Mori, Tomi, 120.12 Moxham, Sarah, 53.2 Munoz, Luis, 70.7 Nagao, Keisuke, 58.12 Nasouf, Luqman, 120.22 Moriarty, Alina, 121.14, Moy, Lindsay, 196.17 Muñoz-Valle, Jose,´ Nagao, Mizuho, 130.35 Nasrullayeva, Gulnara, 122.12, 182.75 Moya, Rosa, 182.24 182.40 Nagarkatti, Mitzi, 67.10, 182.5 Morikis, Vasilios, 64.13 Moya, Zoila, 128.20 Munter, Hans, 190.27 135.18, 183.4, 185.4, Natale, Maria, 190.60 Morissette, Bruno, Moyron-Quiroz, Juan, Muntjewerff, Elke, 185.6, 190.30 Natarajan, Kannan, 73.13 128.20 117.5, 177.7 Nagarkatti, Prakash, 177.15, 177.31 Morita, Craig, 138.16 Mtetwa, Godwin, 62.21, Mura, Thibault, 50.12 115.24, 138.9, Natrajan, Ayithan, Morley, Sharon, 117.14 194.17 Murakami, Akikazu, 182.20, 183.14, 140.19 Morman, Rosemary, Mu, Hong-Hua, 178.9 130.32 191.10, 192.12 Natwick, Dean, 127.10 65.10 Mu, Qinghui, 178.10, Murakata, Yoshiko, Nagasaka, Reina, 119.3 Naudion, Sophie, 52.14 Moroney, Justin, 178.11 74.15 Nagler, Cathryn, 67.6, Nava Estrada, Griselda, 123.14, 195.6 Mucciolo, Gianluca, Murali, Ramachandran, S98 132.11 Morowitz, Michael, 71.4 186.12 Nagy, Gregory, 186.9 Nava, Porfirio, 118.18 192.10 Muchena, John, 179.3 Muralidharan, Nagy, Nancy, 64.24 Navarro-Hernandez, Morozova, Kateryna, Muchiri, Benson, Abenaya, 139.13 Nagy, Tamas, 127.21 Itze, 51.3, 179.8 177.21 190.39 Muranski, Pawel, 52.5 Naidoo, Rishendran, Navert, Robert, 126.38 Morris, Robert, 135.30 Muda, Marco, 195.11 Murasaki, Sayuri, 54.3 182.69 Navid, Fatemeh, 133.11

156 AUTHOR/SPEAKER INDEX

Nazmi, Ali, 192.2 Ng, Xuan Rui, 138.12 Nilles, Matthew, 135.27, Nurieva, Roza, 124.12, Oh, Jiyoung, 53.8, 68.1 Ndunga, Francis, S34 Ngai, Ho, 195.27 196.24 138.18 Oh, Karin, 73.2 Ndao, Malick, 126.3 Ngo, Hanh, 74.10 Ning, Huan, 55.17 Nwankwo, Anthony, Oh, Kyu Seon, 125.17 Neal, Lori, 190.14 Ngu, Mee Kee Esther, Nishiguchi, Tomoki, 140.9 Ohama, Hideko, Neary, Bridget, 50.10 196.8 62.21, 194.17 Nyamajenjere, Tsitsi, 120.14, 195.14 Nedley, Neil, 50.14, Nguyen, Breanna, Nishimura, Hiroyuki, 181.9 Ohno, Tatsukuni, 55.10 50.15 133.11 183.16 Nyangahu, Donald, Ohtsuji, Mareki, 183.16 Nedospasov, Sergei, Nguyen, Cuong, 196.2 Nishimura, Marc, 64.1 72.10 O’Huigin, Colm, 191.6 126.2 Nguyen, Dang, 181.8 Nishiyama, Nina, 123.6 Nyhoff, Lindsay, Oida, Takatoku, 64.15 Nee, Kevin, 135.4 Nguyen, Deborah, Niu, Xinying, 66.4 115.14, 178.17 Ojcius, David, 185.15 Neef, Tobias, 68.5 196.28 Nizet, Victor, 181.21, Nziza, Nadege, 50.12 Ojo, Oluwagbemiga, Neela, Venkata Sanjeev Nguyen, Doan, 123.20, 185.1, 190.43, 179.5, 179.10 Kumar, 181.19 181.16 190.46, 196.28 Okal, Abood, 119.5 Neeld, Dennis, 60.13 Nguyen, Dzung, 128.20 Njikan, Samuel, 139.5 O Okamoto, Kazuo, 189.3 Nefedova, Yulia, 137.4 Nguyen, Felicia, 66.10 Nocito, Cassandra, O.A.T., Alli, 120.29 Okamura, Tomotaka, Negash, Markos, 190.56 Nguyen, Hong, 61.2, 132.9 O`Rourke, John, 52.22, 74.15 Negatu, Seble, 51.18 138.6, 189.12 Noda, Taisei, 55.10 131.7 Okan, Aslı, 59.14 Negris, Olivia, 119.11 Nguyen, Nu Z., 190.55 Nolan, Garry, S40 O’Brien, Dana, 59.17 Okazaki, Hideki, 183.16 Negron, Austin, 123.4 Nguyen, Quang Tam, Nolan, Joshua, 194.37 O’Meara, Connor, 183.3 O’Ketch, Marvin, 75.7 Negroni, Maria Pia, 119.12 Nolz, Jeffrey, 117.16 Oaks, Zachary, 115.6 Okumura, Ko, 54.8 177.21 Nguyen, Quy, 135.4, Nomura, Natsuko, Obajemu, Adeola, Okunnu, Busola, 126.19 Neidleman, Jason, 193.10 194.22 182.48 Okus, Fatma, 193.12 66.12 Nguyen, Quynh, 186.2, Nookala, Sita M, 70.15 O’Barr, Stephen, 187.15 Oladipupo, Favour, Nekhai, Sergei, 187.35 188.8 Nookala, Suba, 120.30 Oberle, Suzan, 71.19 123.10 Nelin, Leif, 187.1, 187.2 Nguyen, Son, 51.5, Nordgren, Tara, 185.9 Oberst, Andrew, 58.2 Olatunde, Adesola, Nellikappallil, Jose, 64.5 130.4, 189.7 Nording, Henry, 126.25 Obregon-Henao, 190.29 Nelman, Mayra, 182.15 Nguyen, Thi, 74.12 Norris, Karen A., S158 Andres, 139.1 Olayemi, Gbemi, Nelson, Alexander, Nguyen, Thomas, 65.14 Norris, Paula, 194.41 O’Brien, Donalee, 133.16 123.17 Nguyen, Tina, 182.64 Norton, Elizabeth, 182.69 Oldham, Austin, 67.12 Nelson, Alfreda, 68.18 Nguyen, Vinh, 52.4, 125.16, 139.7, 139.8, O’Brien, Grace, 136.16 Olferiev, Mikhail, 50.8 Nelson, Andrew, 196.2 132.3 139.16 O’Brien, Martha, 52.19 Olin, Brandy, 51.11 Nelson, Christine, Nguyen, Vu, 182.30 Nosaka, Nobuyuki, Ochs, Bjorn,¨ 53.18 Olivares-Villagomez, 57.18, 190.78, 194.6 Nguyet Pham, Minh, 187.17 O’Clair, Belinda, 130.30 Danyvid, 117.20, Nelson-Filho, Paulo, 207.1 Notarangelo, Luigi, O’Connell, Jennifer, 192.2 181.12 Ni, Jing, S160 52.14 182.35 Olive, Andrew, S154 Nemazee, David, 72.8, Nian, Hong, 133.10 Nott, Alexi, 187.21 O’Connor, Brian, 67.9 Oliveira, Valeria,´ 136.10 139.25, 178.6, 187.6 Nicholas, Dequina, Nouri-Shirazi, Mahyar, O’Connor, James, Oliveri, Lauren, 195.9 Nenasheva, Tatiana, 58.6, 182.25 69.18 122.1, 122.14 Oliviero, Salvatore, 52.2 120.18 Nichols, James, 180.12 Novack, J., S30 O’Connor, Roddy, Olk, Sandra, 61.12 Nepom, Gerald, 52.15 Nicholson, Lindsay, Noval Rivas, Magali, 131.22 Ollmann Saphire, Erica, Netherby, Colleen, 72.12 67.1 O’Connor, Shelby, S199 181.25 Nicholson, Lowell, 70.20 Novelli, Francesco, 177.29, 190.2, 190.36 Olman, Mitchell, 58.4, Neumann, Christian, Nicolasen, Mara, 117.5 71.4 O’Donnell, Joanne, 59.4 127.7 57.19 Nicosia, Michael, 186.8 Nowakowska, O’Donnell, Kyle, 196.24 Olmo-Fontanez,´ Neuper, Theresa, 70.23 Niebergall, Emily, Dominika, 193.13 Odunsi, Kunle, 137.13 Angelica,´ 62.20 Nevell, Julian, 182.64 53.25, 182.84 Nowakowska, Oehrle, Katherine, Olofsson, Karl, 131.29 Nevin, James, 58.15 Niebuhr, Christopher, Malgorzata, 139.16 62.15 Olsen, Cathy, 51.20 Newberry, Rodney, 190.59 Nowell, Cameron, 59.4 Oesterreich, Steffi, Olshansky, Moshe, 126.3, 129.17, 181.28 Nielsen, Jens, 134.6 Noyes, David, 194.42 187.23 60.11 Newcomb, Dawn, Nielsen, Morten, Nuccio, Sean-Paul, Oestreich, Kenneth, Olson, Alex, 120.6 119.16 130.20, 195.12 190.6 64.3, 117.11, 124.6, Olson, James, 194.41 Newland, Dale, 133.7 Niemela, Julie, 76.16 Nundel, Kerstin (Kiefer), 124.11, 128.8, 188.7 Olson, Julie, 75.2 Newman, Jenna, 136.6 Nieto, Jane Eyre, 55.19 179.12 O’Flanagan, Stephen, Olson, Margaret, 134.9 Newsom-Stewart, Niino, Kerri, 54.1, 126.2 Nunez, Sha’Kayla, 138.3 Olson, Matthew, 69.6 Catherine, 135.9 Nikbakht, Neda, 129.5 52.7, 52.8 Ofotokun, Igho, 192.16 Olszewski, Michal, Neyrolles, Olivier, 66.2, Nikitina, Irina, 120.18 Nunez, Sha’kayla, Ogbonna, Oluchi, 180.6 190.9, 190.14 190.79 Nikolajczyk, Barbara, 181.17 O’Grady, Mike, 130.16 Oltz, Eugene M., S98 Ng, Andrew, 119.5 182.25 Nunez, Sha’Kayla, Oh, Hyoungbin, 186.10 Olvera-Rodriguez, Ng, Hang Pong, 187.33 Nikolich-Zugich, Janko, 194.36 Oh, In Soo, 75.23 Felipe, 138.10 Ng, Melissa, 124.9 121.9, 189.2 Nuñez-´ Alvarez,´ Carlos, Oh, Jangsuk, 123.1 O’Mara, Mary, 188.11 Ng, Perry, 55.5, 55.6 Nikulina, Nadya, 130.23 179.7 Oh, Ji Eun, 129.16 Omer, Bilal, 71.9

157 AUTHOR/SPEAKER INDEX

Omilusik, Kyla, 60.14, Osmulski, Pawel, 195.5 Painter, Gavin, 134.8, Papanna, Ramesha, Parks, Christopher, 138.6, 189.12 Ostrand-Rosenberg, 196.27 62.14, 120.10 177.30 Omosun, Yusuf Suzanne, S98 Pais, Roshan, 126.32 Papillion, Amber, 119.26 Parney, Ian, 194.19 Omosun, 126.32 Ostruszka, Leo, 131.1 Pak, HuiSong, 70.13 Papinska, Joanna, Parra-Ortega, Israel, On, Kathy, 122.11 O’Sullivan, Timothy, Pak, Hyo-Kyung, 51.19 178.15, 180.16 118.18 Onabajo, Olusegun, 187.8 Pal, Sarit, 54.10 Papp, Audrey, 62.4 Parra-Reyna, Brenda, 182.48 Oswald, Douglas, Pal, Srabani, 182.70 Paragas, Violette, 182.40 O’Neill, Katelyn, 126.31 117.18 Palacio, Nicole, 75.8 195.11 Parrish, Colin, 130.5 O’Neill, Luke, 58.11, Ota, Takayuki, 139.25 Palaga, Tanapat, 64.21 Paraiso, Hallel, 165.1 Parry, Christian, 187.35 125.11 Ota, Yuko, 73.3 Pallesen, Jesper, Parameswaran, Sreeja, Partida-Sanchez, Onfelt, Bjorn, 131.29 Otero, Dennis, 117.25, 177.31 197.11 Santiago, 59.12 Ong, Seow Theng, 187.36 Pallikkuth,Suresh,72.11 Pardo, Julian, 69.6 Parween, Farhat, 138.12 Othy, Shivashankar, Palma, Paolo, 72.11 Pardoll, Drew, 115.23 117.23 Ongalo, Joshua, 190.39 193.10 Palmeira, Pedro Pardy, Ryan, 197.6 Paschall, Amy, 195.26 Ongoiba, Aissata, 126.7 Ott, Jeannine, 73.3 Henrique, 120.15 Pares, Albert, 132.17 Pascual, David, 196.2 Ontiveros, Carlos, Ott, Martina, 135.14 Palmer, Mitchell, 73.16 Parikh, Bijal, 75.6 Pascual, Virginia, 62.11 Otterbein, Leo, 182.43 Palomino, Gustavo, Parikh, Kathan, 71.9 117.19 Onwuha-Ekpete, Lillian, Ouedraogo,´ Oumarou, 136.10 Parikh, Samir, 182.17 Pasillas, Martina, 59.2, 56.3, 180.8 181.8 Palsson-McDermott, Parish, Christopher, 187.21 Onyema, Oscar, 69.9 Ouerkaxi, Wushouer, Eva, 125.11 183.3 Pastar, Irena, 126.31 Ootomo, Takuya, 195.35 Pamer, Eric, 66.8 Parish, Tanya, 139.5 Pastore, Christopher, 177.26 Oukaa, Mohamed, Pan, Diganta, 122.2 Park, Areum, 121.3 126.1, 190.44, 192.8 Opata, Michael, 190.24, 189.16 Pan, Jingxi, 131.36 Park, Byung, 120.12 Patel, Akshay, 53.2 190.85 Oukka, Mohamed, Pan, Keqing, 182.12 Park, Chan-Sik, 51.19 Patel, Anand, 123.16 Ophir, Michael, 194.2 67.24, 193.12 Pan, Shuai, 130.40 Park, Chung-Gyu, Patel, Deven, 130.28 Opiyo, Stephen, 55.4 Ouyang, Zhengyu, Pan, Wenjing, 131.6, 57.22 Patel, Paresh, 192.4 Oppenheim, Joost, 59.2, 187.21 131.24, 131.25, Park, Eun Jae, 51.17 Patel, Preeyam, 67.9 68.17 Overall, Sarah, 130.4, 131.28 Park, Eun Jung, 126.15 Patel, Sehrish, 60.20 Oravecz-Wilson, 177.31 Panda, Abir, 194.4 Park, Gayoung, 56.21 Patel, Shivani, 66.11 Katherine, 56.6 Overton, James, Pandey, Ahwan, 52.1 Park, Gyeongsin, Patel, Sima, 137.4 Orhan, Eda, 59.14 130.26, 131.16, Pandey, Aseem, 190.31 192.18 Patel, Sweta, 118.14 Oriss, Timothy, 119.1, 131.20 Pandey, Manoj, 181.9 Park, Heon, 64.18 Patil, Veena, 185.1 119.15 Owens, Charles, 69.46 Pandher, Upkar, 119.30 Park, Hong-Jai, 181.22 Patnaik, Anuja, 186.10 Ormseth, Michelle, Oya, Yoshihiro, 57.17 Pandiyan, Pushpa, Park, HwanHee, 182.9 Patras, Kathryn, 190.43 116.14 Ozato, Keiko, 138.6, 57.15 Park, Hye Jung, 120.8 Patrick, Kristin, 189.14 Ornatsky, Olga, 131.2 195.26 Pando, Alejandro, Park,Hyeongjun,196.25 Patrick, Michael, 65.14 Orndorff, Samantha, 136.26 Park, Jeong Woo, Patrone, Julia, 68.15 73.4 Pandori, William, 190.6 127.24 Patterson, Dillon, 50.10, Orozco, Robin, 140.8 P Pandy, Shilpi, 72.9 Park, Jeongho, 122.5 188.2 Ortega, Sterling, 182.55 Packard, Thomas, Pandya, Shivani, Park, Ji Soo, 118.4, Patterson, John, 50.7 Ortega-Blake, Ivan,´ 66.12, 197.2 119.15 119.24, 177.4, 177.13 Patterson, Jordan, 51.3 Paczesny, Sophie, 69.6 Panes,` Rebecca,´ 184.7 Park, Jihye, 177.31 182.39 Ortiz-Carpena, Jorge, Padilla Gutierrez, Jorge Panfil, Amanda, 75.16 Park, Jun Woo, 119.8 Pau, Alice, 182.88 129.1 Ramon,´ 135.24 Pang, Zheng, 127.2 Park, Jung-Eun, 73.12 Paudel, Sagar, 62.5, Ortiz-Navarrete, Padilla-Gutierrez,´ Panicker, Anjali, 196.30 Park, Junsik, 195.2 62.17, 126.24 Vianney, 118.18 Jorge, 182.40 Pankratz, Jennifer, Park, Kyueon, 184.6 Paul, Amber, 182.13 Orton, Taylor, 196.16 Padler-Karavani, 130.27 Park, Paul, 69.42 Paul, Friedemann, Osan, Jaspreet, 131.39 Vered, 70.14 Panneerseelan- Park, Seo, 140.3 68.12 Osborn, Mark, 69.10 Padron, Alvaro, 136.3, Bharath, Leena, Park, Seon-young, Paul, Sinu, 120.23, Osborne, Douglas, 136.15, 195.5 182.25 58.10 130.3 52.17 Paez, Patrick, 54.12 Pannier, Angela, Park, Simone, 138.2 Paulus, Aneel, 71.12, Osborne, Lisa, 66.23 Pagano, Patrick, 59.7 139.14 Park, Sinyoung, 193.2 71.13 Osborne, Melissa, Pahar, Bapi, 122.2 Panoskaltsis-Mortari, Park, Soojin, 139.18 Pavelko, Kevin, 126.5 120.32 Pahwa, Savita, 72.11 Angela, 69.10 Park, Su-Hyung, Pavlakis, George, 72.4 Osborne-Nishimura, Pai, Fu-Tzu, 133.14 Pantouris, Georgios, 136.13, 189.15, 195.2 Pavlov, Valentin, Erin, 64.1 Paidipally, Padmaja, 51.9 Park, Sung-Gyoo, 133.17 O’Shea, John, 140.2 66.15, 66.18, 181.19 Panwar, Bharat, 186.6 182.85 Pawar, Hitesh, 50.1 Osman, Iman, 194.5 Paige, Christopher, Panyi, Gyorgy, 131.9 Park, Sung-Kyun, Payne, Kyle, 135.25, Osman, Wissam, 71.11 Panyi, Gyorgy,¨ 184.3 123.13 138.4, 138.22, 194.2 182.60 Paik, Wonbeom, 69.37, Papadimitriou, John, Park, Sungtae, 69.6 Paynich, Mallory, 65.3 Osmond, Taryn, 196.27 190.47 132.3 Park, Yeon-Hwa, 181.5 Paz, Katelyn, 69.42

158 AUTHOR/SPEAKER INDEX

Pazare, Amar, 177.11 Perez, Rebecca, 123.4 Pham, Andrew, 52.1 Pitt, David, 52.15 Pourhabibi Zarandi, Pear, Warren, 60.16 Perez, Tamara, 67.8 Pham, Duy, 124.10 Pitzka, Christina, Nima, 197.13 Pearlman, Eric, 190.4 Perez-Cruz,´ Magdiel, Phan, Anh, 124.5 130.31 Pourpe, Stephane, Pease, Larry, 177.30 52.15 Phan, Anthony, 190.11 Pizutelli, Vanessa, 66.5 137.3 Pecaut, Michael, 123.6 Perez-Potti,´ Andre,´ Phan, Quynh, 190.4 Pizzato, Hannah, Poursine-Laurent, Peck, Misty, 190.1 196.23 Phan, Sem, 182.3 118.17 Jennifer, 75.6 Pecor, TIffany, 139.5 Perez-Sanz, Jairo, Phillips, Ashlee, 75.24 Plas, David, 181.26 Powell, Jonathan, S200 Pedram, Michael, 138.22 Phillips, Elizabeth, Plaza, Anita, 73.19 Powell, Michael, 64.3, 185.15 Perez-Vazquez, Marta, 140.14 Plumlee, Courtney, 124.6, 124.11, 188.7 Pedros, Christophe, 190.70 Phillips, Joy, 66.20 72.10 Powell, Micheal, 128.8 76.17 Perfect, John, 190.9 Phuah, Jia Yao, 190.2 Poggi, Susana, 190.79 Powis, Garth, 117.25 Pedroza Gonzalez,´ Perl, Andras, 115.6 Phung, Wilson, 131.19 Pohl, Calvin, 54.2 Pradhan, Pallab, 196.7 Mariana, 135.24 Perlman, Stanley, Piazuelo, M. Blanca, Pohl, Jan, 139.17 Pradhan, Suman, Peebles, Jr., Ray, 140.13, 183.7, 198.4 192.2 Poholek, Amanda, 130.33 181.15 Perot,´ Brieuc, 75.11 Piccirillo, Ann, 122.3 119.15, 128.11 Prado De Maio, Diego, Peel, Jessica, 51.10 Perota, Andrea, 70.14 Piccoli, Luca, 133.2 Poincloux, Renaud, 186.16 Pegu, Amarendra, 72.6 Perou, Charles, 195.18 Pichilingue-Reto, 190.79 Prakash, Annamneedi, Pei, Han Zhong, 52.6 Perros, Alexis, 182.69 Patricia, 120.9 Poinsatte, Katie, 182.55 119.8 Peikert, Tobias, 190.20 Perry, Joseph, 122.5 Pichugin, Alexander, Pokkali, Supriya, 139.3 Prasad, Sudhir, 120.13 Peixoto, Rephany, Persidsky, Yuri, 132.9 190.48 Polanco, Jonilee, Prat, Alexandre, 120.15 Persky, Leah, 182.25 Piecychna, Marta, 51.9 131.39 182.38, 182.66 Pelanda, Roberta, Person, Anthony, 124.4 Piedra-Quintero, Politano, Gianfranco, Pratap, Harsh, 72.12 179.14 Pertsemlidis, Zayda, 190.81 52.2 Pratt, Arthur, 179.9 Pelletier, Marc, 186.8 Alexander, 123.14 Pierce, Spencer, Polovina, Anya, 196.28 Pratumchai, Pelluard, Fanny, 52.14 Pervolarakis, Nicholas, 139.23 Poltorak, Alexander, Isaraphorn, 121.4, Peltier, Daniel, 56.6 135.4 Pierce, Susan, 121.2, 63.11 140.8 Pena, Mirna, 121.2 Peshkova, Iuliia, 118.2, 121.5, 128.6, 190.7, Polz, Robin, 51.2 Pravetoni, Marco, 70.18 Pena-Briseno, Alma, 191.12 190.45 Pomaznoy, Mikhail, Premawansa, Sunil, 198.1 Pestka, James, 117.6 Pierer, Matthias, 180.9 120.20, 130.15, 140.11 Penaloza-MacMaster, Petenkova, Anastasia, Piersma, Sytse, 75.6 131.27, 190.50, Presa, Maximiliano, Pablo, 75.8, 140.12 127.22 Pierson, Duane, 182.15 196.12 115.8 Pene, Jerome, 50.12 Peter, Cara, 182.6 Pierson, Mark, 189.9 Pone, Egest, 131.32 Prescher, Martin, 127.8 Peng, Bi-Hung, 139.10 Peters, Bjoern, 55.1, Pietrzak, Maciej, 52.5, Ponnana, Meenakshi, Presman, Diego, 53.12 Peng, Changwei, 56.13 70.16, 71.14, 120.20, 62.4 120.13 Price, Madeline, 123.8, Peng, Guangyong, 120.23, 130.3, 130.15, Pietz, Nicole, 130.31 Poo, Haryoung, 139.15 188.15 137.9 130.20, 130.26, Pihl, Riley, 120.6 Poojary, Venuprasad, Price, Robert, 138.9 Peng, Guiying, 55.14 131.16, 131.18, Pilewski,Joseph,182.31 194.34 Prince, Lawrence, Peng, Junmin, 53.19 131.20, 131.27, 134.1, Pilewski, Kelsey, 72.7, Pookot, Deepa, 119.5 126.4, 187.19, 190.43 Peng, Mary, 50.8 134.11, 140.11, 138.7 Poole, April, 182.88 Pritzl, Curtis, 197.5 Peng, Paul, 70.9 140.14, 182.27, 186.6, Piliponsky, Adrian, Poon, Grace, 130.18 Prizant, Hen, 51.18 Peng, Peng, 123.11 190.50, 196.12, S153 54.1, 126.2 Poonia, Bhawna, Procko, Erik, 177.31 Peng, Tien, 129.1 Petersen, Andreas, Pillai, Meenu, 74.6 140.19 Proctor, Elizabeth, Peng, Weiqun, 65.14 192.3 Pillay, Santhoshan, Popescu, Maria, 188.5 182.25 Penna, Vinay, 57.7, Peterson, Theodore, 76.11 Popik, Waldemar, 63.2 Prodeus, Aaron, 71.5 116.13 53.6 Pillers, Michelle, 131.12 Popovich, Dillon, Prokunina-Olsson, Pennamen, Perrine, Petlakh Co, Nadia, 131.1 Pilling, Darrell, 126.11 182.37 Ludmila, 182.48 52.14 Petro, Christopher, Pilotos, Jennifer, Porcelli, Steven, 177.1 Provosty, William, Pennell, Christopher, 196.12 190.85 Porrett, Paige, 189.17 139.16 194.6 Petronilho, Fabricia, Piñeiros Alvarez, Annie Porritt, Rebecca, 120.4 Puerta, Concepcion,´ Penttinen, Anna-Maija, 120.11 Rocio, 185.14 Porter, Christopher, 126.26 177.27 Pevzner, Pavel, 131.38 Pinfold, Esther, 61.19 52.1 Pugsley, Haley, 131.5 Pepe, Russell, 136.6 Pewe, Lecia, 117.4, Pingris, Karine, 190.79 Porter, Edith, 67.20 Pulendran, Bali, 196.12 Pepin, Deanna, 55.7 193.11 Pinilla, Clemencia, Porter, Katelyn, 72.8 Pullen, Nicholas, Perales-Puchalt, Pfaller, Christian, 182.57 Posadas, Edwin, 120.4 133.15, 135.22 Alfredo, 138.22, 183.19 Pioli, Patricia, 135.17, Posarac, Vesna, Punch, Patrick, 188.6 194.2 Pfeffer, Klaus, 126.6, 182.37 130.14 Puni, Ron, 61.11 Perelas, Apostolos, 126.18, 127.8, 190.87 Pioli, Peter, 118.10 Postma, Britten, 117.6 Puray-Chavez, Maritza, 58.4 Pfeiffer, Katherine, Pipkin, Matthew, 138.6 Pot, Caroline, 124.14 197.21 Perelson, Alan, 72.6 131.4, 131.13, 194.29 Pires, Karla M., 185.10 Potter, Ashley, 116.12 Purcell, Anthony, 74.12 Perez Sanz, Jairo, Pham, Michael, 121.14, Pisanelli, Giuseppe, Poudel, Barun, 127.3, Purcell, Lisa, 196.12 138.4, 194.2 182.75 127.18 198.3 Purohit, Suman, 135.25

159 AUTHOR/SPEAKER INDEX

Putterman, Chaim, Qureshi, Mohamed, Rajapakshe, Kimal, Rana, Sabhya, 190.19 Ray, Jessica, 117.7 182.8, S209 50.16 194.17 Rana, Tariq, 185.1 Ray, Prabir, 119.1 Putty, Trishni, 126.34 Qureshi, Mahboob, Rajaram, Murugesan, Rancan, Chiara, 129.8 Ray, Rashmi, 135.20 Putzel, Gregory 119.22 62.3, 190.66 Randall, Troy, 123.8, Rayalam, Srujana, Garbe`s, 191.3 Rajasekaran, 195.7 182.58, 182.89 Pyaram, Kalyani, 65.9 Narendiran, 194.37 Randolph, Gwendalyn, Rayasam, Aditya, Pyle, Anna, 194.28 R Rajcula, Matthew, 133.5 117.13, 121.10 Raab, Monika, 184.4 53.17, 56.15, 68.16, Randolph, Gwendalyn Rayavara Kempaiah, Rabinovich, Gabriel, 135.8 J., S175 Kempaiah, 120.28 Q 63.14, 126.36 Rajput, Mrigendra, 73.11 Rane, Sushmita, Rayavara, Kempaiah, Qadri, Ayub, 63.5, Rabinowitz, Benjamin, Rajsbaum, Ricardo, 140.21 120.27 63.13 71.1, 130.1 64.16, 127.13 Rangel-Moreno, Javier, Raybuck, Ariel, 186.17 Qeadan, Fares, 52.9 Rabinowitz, Joshua, Raju, Nagarajan, 138.7 182.68 Raychaudhuri, Qi, Cheng-Feng, 178.2 137.1 Rakesh, Prateek, Rani, Reena, 181.9 Kumarkrishna, Qi, Jianxun, 197.26 Rachubinski, Angela, 186.11 Ranjan, Priya, 139.17 120.26 Qi, Jun, 69.42 52.1 Ram, Sanjay, 137.13, Ransier, Amy, 189.7 Raychaudhuri, Qi, Lin, 194.41 Racine, Jeremy, 50.6, 190.46 Ransohoff, Richard, Soumya, S209 Qi, Xiaodong, 70.22 115.5, 115.8, 115.15 Ramachandran, 51.21 Raynaud-Messina, Qi, Xiaoying, 194.13 Rackaityte, Elze, Venkataraman, Rao, Anjana, 65.3, Brigitte, 190.79 Qi, Xiulan, 119.21, 186.4 191.17 195.24 123.15, 131.18, Raynor, Jackson, 134.9 Qian, Hongyan, 182.2 Racz, Greta, 131.9 Ramakrishna, 134.3, 182.27 Razlog, Maja, 195.11 Qian, Jun, 137.2 Rada, Balazs, 127.21 Chandran, 63.3 Rao, Anna, 65.6, Read, Kaitlin, 64.3, Qian, Xiaoning, 190.31 Radhakrishnan, Ramakrishnan, 187.10 117.11, 124.6, Qian, Youcun, 127.23 Rajesh, 66.15, 181.19 Parameswaran, Rao, Ganesh, 135.14 124.11, 128.8, 188.7 Qiao, Guanxi, 136.27, Radhakrishnan, Rajesh 116.15 Rao, Mekhala, 54.5 Reagan, John, 136.26 195.23 Kumar, 66.18 Ramalingam, Suresh, Rao, Ramesh, 131.38 Reagin, Katie, 128.15 Qiao, Luxin, 194.16 Radio, Nicholas, 187.23 70.7 Rao, Samhita, 195.3 Reardon, Colin, 66.16 Qin, Hongwei, 52.3, Raffaelli, Nadia, 52.2 Raman, Lakshmi, Rao, Xiaoquan, 182.29 Reber, Laurent, 126.2 188.1 Raffatellu, Manuela, 182.55 Rapecki, Stephen, Rebollar-Ruiz, Xochitl Qin, Jing, 72.13 190.6 Ramanan, Meera, 123.23 Abril, 67.23 Qin, Lei, 70.12, 124.12, Raffin, Caroline, 133.2 182.89 Rase, Viva, 135.22 Redd, Priscilla S., 134.7, 185.11, 195.21 Rafizadeh, Tannaz, Ramapriyan, Rishab, Rasheed, Mustafa, 194.8, 195.26 Qin, Qing-Ming, 190.31 194.38 136.11 124.6, 124.11 Redden, Catherine, Qin, Yue, 185.1 Raghavan, Malini, 60.3 Ramaswamy, Vijay, Rasi, Valerio, 190.10 122.17 Qiu, Connie, 180.17 Ragheb, Jack, 186.10 194.41 Rasko, David, 190.70 Reddy, Jay, 115.3, Qiu, James, 195.11 Rahaman, Rafid, 182.6 Ramer-Tait, Amanda, Rasouli, Javad, 50.18 180.19 Qiu, Xiaoyan, 186.5 Rahkola, Jeremy, 72.12 191.3 Rast, Jonathan, S26 Reddy, Pavan, 56.6 Qu, Ganlin, 132.6 Rahman, Mohammad, Rameshwaram, Rath, Jan, 135.4 Redelman, Doug, Quach, Alex, 126.34 140.9 Nagender, 190.57 Rath, Satyajit, 192.6 182.50 Quarnstrom, Clare, Rahman, Mohammad Ramet, Lauriane, Rathinam, Chozha, Redmond, David, 57.18 Arif, 72.5, 75.20 177.27 53.10, 187.27 134.13 Quarta, Stefano, 190.59 Rahman, Negar, 64.26 Ramezani-Rad, Rathinam, Vijay, 63.14, Redmond, Sarah, 61.8 Queener, Ashley, 119.3 Rahman, Sheikh, 76.6 Parham, 185.16, 126.36 Reed, Elaine, S153 Queva, Timothy, 50.15 Rahman, Ziaur, 121.12 188.4 Rathkey, Joseph, 51.21 Reed, Madison, 177.18 Quick, Hannah, 198.3 Rai, Kanti, 182.62 Ramirez Celis, Nora, Rathmell, Jeffrey, 60.2, Reed-Maldonado, Quiding Jarbrink,¨ Rai, Vivek, 135.20 130.9 117.20, 119.16, Amanda, 130.11 Marianne, 138.13, Raimondi, Giorgio, Ramirez Suastegui, 137.10 Reese, Valerie, 139.5 138.14 68.15, 69.32, 69.33, Ciro, 186.6 Ratliff, Michelle, 118.7 Reeves, R. Keith, 76.4 Quilter, Gale, 61.22 116.8 Ramirez, Ciro, 65.1 Rattan, Ramandeep, Refaeli, Yosef, 69.10 Quinet, Robert, 133.16 Raj, Prithvi, 120.9, Ramirez, Francisco, 135.30, 183.12 Refai, Mohammed, Quinlan, Anna, 115.8 182.32 50.14, 50.15 Raudonis, Renee, 180.8 Quinn, Kylie, 60.7 Rajagopalan, Ramirez, Valerie, 66.16 127.2 Regev, Aviv, 124.14, Quinn, William, 137.1 Govindarajan, 190.34 Ramm, Georg, 60.7 Raue, Andreas, 195.11 137.15 Quintana, Francisco J., Rajagopalan, Sumati, Ramos, Hilario, 70.21 Raval, Forum, 182.25 Regla-Nava, Jose, 193.13, S201 S47 187.9 Rampanelli, Elena, Ravindranathan, Sruthi, 140.5, 140.15 Quinton, Lee, 66.22 Rajakaruna, Harshana, 197.4 71.17 Rehan, Virender, Quirino, Gustavo, 122.14 Ramsay, Joshua, 73.20 Ravindranathan, Sruthi, 122.10 190.42 Rajala, Johanna, Ramsey, Haley, 137.10 70.8, 71.2 Reid, Gregor, 192.3 Qulieva, Feride, 59.14 177.12 Ramsey, Kyle, 196.17 Rawluk, Justyna, 53.18 Reilly, Christopher, Quon, Sara, 125.6, Rajan, Sharmila, Ramsey-Goldman, Rawson, Travis, 59.13 178.10 138.6 131.19 Rosalind, 182.8 Ray, Anuradha, 119.15 Reiner, Steven, 124.13

160 AUTHOR/SPEAKER INDEX

Reinhardt, R Lee, 67.9 Richards, Jennifer, Robert-Guroff, Marjorie, Rogers, Meredith, 198.2 Rostomily, Clifford, 59.6 Reis, Edimara, 126.25 195.11 72.1, 72.2, 72.3, 72.5, Rohatgi, Soma, 190.32 Rosu-Myles, Michael, Remot, Aude, 66.2 Richards, Michael, 75.20, 140.9, 197.1 Rohlfing, Michelle, 139.13 Rempala, Grzegorz, 74.12 Roberts, David, 186.10 55.13 Roth, Theodore, 124.9 62.4 Richardson, Anthony, Roberts, Kevan, 119.28 Roidan, Daniel, 131.13 Rothschild, Daniel, Ren, Gang, 186.3 190.49 Roberts, Lydia, 67.16 Rojano, Elba, 180.3 129.11 Ren, Heather, 181.25, Richardson, Shakyra, Robertson, Amicha, Rollins, Meagan, 138.3 Rothstein, Thomas, 197.15 126.32 190.27 Romain, Gabrielle, 121.6 Ren, Jinghua, 135.2 Richer, Martin, 197.6 Robinson, Catherine, 134.2 Rouchka, Eric, 192.4 Ren, Junping, 198.9 Richner, Justin, 121.13 57.20, 116.16, 186.11 Romantseva, Tatiana, Roudko, Vladimir, 70.9 Ren, Liming, 73.2 Richter, Anne, 130.31, Robinson, Cory, 59.13, 64.7, 64.8 Roussey, Jon, 131.1 Renavikar, Pranav, 134.15, 194.26 190.18 Rome, Kelly, 60.16 Rousso-Noori, Liat, 57.11, 57.13 Richwalls, Lacee, 66.11 Robinson, Garrett, Romero, Laura, 126.31 135.23 Rendahl, Aaron, 73.9 Richwine, Madison, 70.21 Romero, Maria, 121.8, Roux, Cecilia, 71.4 Rene, Olivier, 133.3 116.12 Robinson, John, 138.22 179.4 Roy Chowdhury, Renelt, Mark, 124.4 Rickert, Robert, 188.4 Robinson, Jonathan, Romero, Megan, 194.41 Sougata, 135.25 Renfro, Zachary, 126.10 Riddell, Stanley, S107 134.6 Romero, Natalia, 56.16 Roy, Krishnendu, 196.7 Renolds, Carol, 195.31 Ridgway, William, Robinson, KaReisha, Romero, Sandra, 179.7 Roy, Soumen, 190.1 Renrick, Ariana, 136.18 182.28 117.10 Rommereim, Leah, Roy, Soumyabrata, Repasky, Elizabeth, Riethoven, Jean-Jack, Robinson, Rachel, 59.6 196.3 136.27, 195.23 115.3, 180.19 180.3 Rong, Yinghui, 66.25 Roysam, Badrinath, Resendiz´ Mora, Albany, Riffelmacher, Thomas, Robinson, Sage, 134.8 Rooks, Kelly, 182.69 134.2, 134.6 132.11 67.8 Robinson, Sarah, 125.8 Rooney, Cliona, 71.9 Royzman, Kristina, Resendiz-Albor, Aldo Riggs, James, 138.11 Robison, Amanda, Roopenian, Derry, 75.21 Arturo, 67.23 Riha, Nathan, 135.27 127.12 116.12 Rozenblatt-Rosen, Orit, Resiliac, Jenny, 55.13 Riley, John, 67.17, Robledo-Avila, Frank, Rooryck, Caroline, 137.15 Reth, Michael, 75.25 73.14 59.12 52.14 Ruan, Jhen-Wei, 191.8 Rettig, Trisha, 123.6 Rinaldi, Stefano, 72.11 Robles, Ana, 190.1 Roque Simões, Lutiana, Rucevic, Marijana, Reuven, Eliran, 70.14 Rinaldo, Charles, 76.8 Robles, Omar, 119.5 63.6 120.3 Reyes, Alfonso, 184.6 Ringel, Alison, S168 Robles, Rene’, 68.13, Rosa-Campos, Rudd, Christopher, Reyes, Estefany, 53.22 Ringel-Scaia, Veronica, 182.10 Alexandre, 185.16 136.24, 184.4 Reyes, Leticia, 70.5 67.7, 194.31 Robson, Simon, 68.13, Rosas, Adriana, 191.9 Rudra, Jai, 136.6, Reyes, Ryan, 136.14, Rinke, Andrew, 182.3 182.10, 182.43 Rosas-Delgado, Martin 139.2, 177.17 136.15 Riordan, Daniel, 131.4 Rocca, Salvatore, 72.11 Orlando, 70.17 Ruenjaiman, Vichaya, Reyes-Vargas, Riou, Catherine, 190.78 Roche, Paul, 135.16 Rosati, Margherita, 72.4 64.21 Eduardo, 177.19 Riou, Gaetan, 179.6 Rockman, Steve, 74.12 Rosato, Pamela, 189.9, Ruffin, Ayana, 138.15 Reynolds, Joseph, Risinger, April, 137.8 Rockwell, Cheryl, 55.3 194.6 Rughwani, Priyanka, 53.6, 115.19 Rissin, David, 52.21 Rockwood, Stephen, Rose, Aaron, 182.67 130.24 Reynolds, Mack, 190.9 Ritter, Gerd, 136.23 130.10 Rose, Kira, 118.8 Ruiz-Sanchez,´ Bibiana Reynoso, Glennys, Ritz, Jerome, 69.42, Rodgers, Mark, 190.36 Rose, Uriel, 190.1 Patricia, 190.86 56.19, 66.14, 75.18, 195.31 Rodgers, William, 53.24 Roselino, Ana, 52.23 Runtsch, Marah, 58.11, 76.15 Rivara, Kathryn, 51.13 Rodin, William, 138.13, Rosenberg, Roger, 70.3 125.11 Rha, Min-Seok, 120.8 Rivera, Carlos, 121.11, 138.14 Rosenberg, Steven, Rupert, Adam, 182.88 Rhee, Stephanie, 69.42 195.6 Rodriguez del Villar, 134.11 Ruprecht, Klemens, Rheinlaender, Rivera, Gonzalo, Ryan, 70.22 Rosenberg, Steven A., 68.12 Johannes, 126.25 190.31 Rodr´ıguez, Ayda, S174 Rus, Horea, 52.4 Rhoads, J Marc, 193.2 Rivera, Kristian, 131.39 126.26 Rosenthal, Kenneth, Rus, Violeta, 132.3 Rhoads, Jillian, 182.59 Rivera-Mariani, Felix, Rodriguez, Princess, 133.4 Rusert, Jessica, 194.41 Ribbeck, Katharina, 55.18 179.15, 179.16 Rosenzweig, Sergio, Russ, Brendan, 60.11, S161 Rivera-Nieves, Jesus, Roe, Denise, 177.32 76.16 125.6 Ribeiro Junior, Silvio 67.13 Roe, Mandi, 59.16 Ross, Kathleen, 139.11 Russell, David, 190.23 Renato, 63.6 Rivera-Torruco, Roede, James, 54.14 Ross, Ted, 139.19, Russell, Marsha, 139.13 Ricci, Eric, 136.17 Guadalupe, 118.18 Roederer, Mario, 139.3 139.23 Russell, William, 190.31 Riccio, Rachel, 140.3 Rives, Alexander, 75.11 Roers, Axel, S41 Rossi, Paolo, 72.11 Russo, Ashley, 63.14, Rice, Laura, 63.3 Rizzetto, Simone, 74.12 Roesler, Alexander, Rossi, Robert, 117.19 126.36 Rice-Ficht, Allison, Rizzi, Marta, 53.18 121.5, 128.6 Rossjohn, Jamie, 74.12 Rutz, Sascha, 57.19, 190.31 Roan, Nadia, 66.12, Roessing, Anna, 125.12 Rossol, Manuela, 59.5, 133.3, 134.18 Rich, Helen, 66.11, 197.2, 197.14 Roga, Stephane,´ 119.29 180.9, 182.51 Ryan, Andrew, 127.15 198.10 Robb, Renee, 69.38 Rogers, Geoffrey, 72.8 Rostami, Ryan, John, 54.11, Richard, Lyndsay, Robbins, Paul, 134.11 Rogers, Matthew, Abdolmohamad, 54.12, 54.13, 64.9, 190.24 Robek, Michael, 196.18 192.10 50.18 185.5

161 AUTHOR/SPEAKER INDEX

Ryan, Lisa, 192.13 Saito, Tais, 127.17, Sanchez, Michelle, Santosa, Endi, 76.3, Savas-Carstens, Jan, Ryan, Michael, 60.7 139.2, 190.58 126.20 76.9 184.6 Rydyznski, Carolyn, Saiyed, Taslimarif, Sanchez-Lopez, Elsa, Santos-Argumedo, Savic, Sinisa, 63.3 122.16 192.4 125.1, 190.6 Leopoldo, 179.7, Savona, Michael, Ryes, Luz, 69.27 Sakai, Mashito, 59.2, Sanchez-Salguero,´ 179.8, 190.81 137.10 Ryu, Da-Bin, 192.18 187.19, 187.21 Erick, 179.7 Santosh, Swetha, 51.12 Savova, Virginia, Ryu, Seul Hye, 118.4, Sakai, Shunsuke, Sanderford, Victoria, Sanvito, Francesca, 131.15 119.24, 177.4, 190.78, 190.82 120.21 178.8 Sawhney, Megha, 63.4 177.13 Sakr, Sharif, 135.30 Sanders, Katherine, Sanz, Ignacio, 50.10, Saxena, Amit, 182.8 Saksena, Suraj, 131.37, 137.9 179.5 Sayin, Ismail, 121.16, 189.18 Sandey, Maninder, Sanz, Iñaki, 123.20, 140.17 S Sakurai, Tetsuya, 55.16 181.16 Scala, Sara, 126.16 Sa, Silin, 131.35 185.12 Sandhu, Simran, 117.11 Saphire, Erica, S199 Scanga, Charles, Saadi, Fareeha, 126.9, Sala, Ester, 180.20 Sandler, Stellan, Sapida, Jerald, 131.13, 139.3, 177.29, 190.2, 126.17 Salazar, Luis, 55.19 182.47, 182.53 194.29 190.36 Saavedra-Avila,´ Noem´ı Salek-Ardakani, Sandor, Matyas, 51.8, Sapoznikov, Anita, Scarneo, Scott, 68.19 Alejandra, 180.20 Shahram, 66.19 117.13, 121.10, 187.32 Schaafsma, Evelien, Saba, Julie, 74.10 Salgado Barrero, 190.40 Sarajlic, Muamera, 182.37 Sabikunnahar, Oscar, 53.16 Sandoval, Wendy, 70.23 Schafer, Carolina, Sabikunnahar, Salgado, Helio, 182.82 131.19 Sardina, Patricia, 177.1 187.26 Salgar, Shashikumar, Sandoval-Montes, 131.41 Schaffer,¨ Alejandro, Sabo, Tamar, 187.32 130.11 Claudia, 190.81 Sareddy, Gangadhara, 186.10 Sabri, Nazila, 184.6 Salimi, Nima, 131.20 Sandquist, Ivy, 139.7, 195.6, 195.29 Schaffer,¨ Tilman, Sachs, Abraham, Salina, Ana, 183.17 139.8 Sargsyan, Ashot, 126.25 134.11 Salinas, Irene, 73.5, Sandstrom,¨ Niklas, 185.10 Schall, Thomas, 133.7 Sackton, Kate, 71.10 S32 131.29 Sarkar, Saumendra, Scharer, Christopher, Sacramento, La´ıs, Salinger, Ari, 124.2 Saney, Celia, 123.20, 198.10 50.10, 51.10, 123.8, 190.22 Saljoughian, Noushin, 181.16 Sarkar, Surojit, 60.15, 188.2, 188.9, 188.15 Sada-Japp, Alberto, 190.66 Sanford, Larry, 182.75 71.16, 181.24 Schartner, Jill, 134.18 130.4 Sallin, Michelle, 190.78 Sangare, Kotou, 72.1 Sarr, Demba, 127.21 Schatz, David, 123.15 Sadee, Wolfgang, 62.4 Salloum, Jillian, 55.5 Sankaranarayanan, Sarvetnick, Nora, 178.5 Schauder, David, Sadeghi, Fatemeh, Salter-Cid, Luisa, S49 Ishwarya, 122.10 Sasabe, Jumpei, 115.20 134.2 Salvador, Ryan, 191.6 Sannula, Kesavardana, 129.15 Scheel-Toellner, Sadegh-Nasseri, Salzer, Ulrich, 53.18 74.8 Sasaki, Hajime, 69.8 Dagmar, 179.9 Scheherazade, Salzman, Nita, 192.21 Sant, Sneha, 74.12 Sasaki, Yo, 64.1 Scheffold, Alexander, 177.14, 177.18, Samaniego Castruita, Sant’Angelo, Derek, Sasiain, Maria del 57.19 177.25 Daniela, 134.3 57.10, 58.9 Carmen, 190.79 Scheiblhofer, Sandra, Sadissou, Ibrahim, Samaniego-Castruita, Santa Maria, Peter, Sasmal, Aniruddha, 70.23 136.10 Daniela, 123.15 190.76 130.5 Scheidegger, Adam, Sadraei, Atieh, 126.37 Samarani, Suzanne, Santamaria, Pere, Sasmal, Dibyendu, 120.30 Sadri-Ardekani, 75.14 132.17 184.10 Scheiermann, Hooman, 197.13 Samarasinghe, Amali, Santamaria-Chavez, Sastry, Jagannadha, Christoph, 117.3 Safonova, Yana, 198.6 Monica Miguel, 67.23 70.15 Schell, Stephanie, 131.38 Samavati, Lobelia, Santambrogio, Laura, Sather, Noah, 72.9 121.12 Sag, Duygu, 187.22 52.12, 187.2 177.21 Sato, Shinichi, 182.42 Scheller, Jurgen,¨ 51.2 Sage, Peter, 69.42 Sambhara, Santana, Alynne, Satyajit, Rath, 126.10 Schelmbauer, Carsten, Saha, Asim, 69.10 Suryaprakash, 140.20 Sauer, Karsten, 71.10, 181.4 Saha, Piu, 59.3, 192.9 139.17 Santangelo, Philip, 136.20, S49 Schenffeldt, Andres, Saha, Shravasee, 71.5 Sampson, James, 196.7 Saultz, Jennifer, 120.12 73.19 Saha, Siddhartha, 195.11 Santhanam, Saunders, Brian, 133.5 Schenkel, Alan, 182.22 67.24, 189.16 Sampson, John, 70.20 Ramasamy, 59.12 Saunders, Eleanor, Schenkel, Jason, Saha, Sudeshna, Sams, Clarence, Santiago, Mario, 179.14 60.7 66.21, 136.6 190.46 182.15 Santibañez,´ Alvaro,´ Sauret, Emilie, 58.16 Schenten, Dominik, Sahoo, Anupama, Samten, Buka, 63.7 177.1 Sauter, Manuela, 75.7 124.12, 138.18 Samuel, James, 190.31 Santoro, Jennifer, 55.13 126.25 Scheraga, Rachel, Sahoo, Manoranjan, Samuels, Janaiya, Santos Tino, Ariana, Sautto, Giuseppe, 58.4, 127.7 137.14 182.58 51.15 139.19, 139.23 Schiessl, Viktoria, 70.23 Sahu, Rajnish, 196.10 Sanchez, Darren, 70.5 Santos, Leonardo, Savage, Hannah, 75.25 Schjerven, Hilde, Saikh, Kamal, 195.25 Sanchez, Helia, 121.11 190.42 Savan, Ram, 59.6, 179.15, 179.16 Sainz-Rueda, Nestor, Sanchez, Jerick, 119.5 Santos, Radleigh, 74.3, 127.15 Schlachetzki, 182.25 Sanchez, Kristina, 75.24 182.57 Savani, Rashmin, 66.4 Johannes, 187.21

162 AUTHOR/SPEAKER INDEX

Schlee, Martin, 198.12, Schulte, Wibke, 51.9 Semon, Alexa, 191.3 Seumois, Gregory, Sharma, Himanshu, S41 Schulten, Veronique,´ Semwal, Manpreet, 65.1, 65.3, 120.20, 196.13 Schlegel, Karolina, 55.1, 120.23 65.15, 65.16 120.23, 131.18, Sharma, Madhav, 130.27 Schulz, Laura, 76.16 Sen Chaudhuri, Arka, 140.11, 186.6, 135.12 Schlesinger, Larry, Schuster, Iona, 69.38 196.5 190.50, 196.12 Sharma, Neekun, 62.3, 62.4, 62.11 Schwardt, Nicole, 58.12 Sen, Ganes, 185.3 Seumois, Gregory,´ 115.16 Schloss, Patrick, 191.1 Schwartz, Jennifer, Senda, Takashi, 60.5, 182.27 Sharma, Prabhat, Schlums, Heinrich, 135.9 129.8 Seyed-Razavi, Yashar, 182.65 76.10 Schwartz, Lawrence, Sengupta, Deepanwita, 117.15 Sharma, Purnima, Schmachtenberg, 54.6 188.11 Sgourakis, Nikolaos, 190.6 Sabine, 130.27 Schwartzberg, Pamela, Sengupta, Monideepa, 130.4, 177.31 Sharma, Rohit, 190.21 Schmidt, Marcel, 120.24 140.2 137.7 Shaaban, Aimen, Sharma, Sandhya, 71.9 Schmidt, Michael, 194.2 Schwarz, Jacob, 119.5 Sengupta, Shouvonik, 122.17 Sharma, Siddhartha, Schmiechen, Zoe, Schwerk, Johannes, 119.6, 186.9 Shabaneh, Tamer, 120.33 182.52 127.15 Sengupta, Soumini, 135.17 Sharov, Alexei, 65.14 Schmiedel, Benjamin, Sciume,` Giuseppe, 125.7 Shadid, Tyler, 190.84, Sharpe, Arlene, 69.42, 125.4, 182.27 181.27 Sengupta, Srona, 196.19 122.10, 195.31 Schmiel, Shirdi, 50.5 Scofield, Barbara, 177.18 Shafiei Jahani, Pedram, Shashidharamurthy, Schmieley, Rebecca, 165.1 Sengupta, Upasana, 51.12 Rangaiah, 182.58, 194.30 Scordo, Julia, 62.20 180.20 Shafran, Jordan, 182.89 Schmitt, Lutz, 127.8 Scott, Bethany, 178.1, Seo, Gil Ju, 63.3 182.87 Shaw, Albert, 181.22 Schmitt, Pauline, 178.2, 179.1 Seo, Gooyoung, 65.1 Shah, Javeed, 66.10 Shaw, Laura, 188.8 119.29 Scott, David, 193.14 Seo, Goo-Young, Shah, Palak, 52.13 Shaw, Mariah, 187.7 Schmitz, Elizabeth, Scott, Evan, 132.15 191.11 Shah, Pranav, 52.12 Shaw, Rebecca, 189.10 119.15 Scott, Megan, 136.2 Seo, Hyungseok, 134.3 Shah, Roshan, 182.82 Shayakhmetov, Dmitry, Schmuke, Jon, 131.12 Scott, Melanie, 190.51 Seo, Jun-Young, 177.4 Shahbaz, Shima, 57.5, 196.7 Schnaider Ramos Scott, Milcah, 66.21 Seo, Kwang-Won, 120.2 Shcheglova, Tatiana, Junior, Erivan, 185.15 Scott, Tamara, 187.18 182.9 Shahi, Shailesh, 70.13 Schneberger, David, Scott-Browne, James, Seo, Young-Jin, 56.22, 178.13, 178.14 Sheehan, Patrick, 190.7 119.30 65.3 197.5 Shaikh, Kiran, 61.21 Sheh, Alexander, 52.13 Schnederman, Sylvia, Seabrook, Melanie, Seong, Ju-won, 119.8 Shakya, Arvind, 115.10 Shelef, Miriam A., 124.2 129.10 71.11 Seong, Rho, 123.12 Shalek, Alex, 190.41 Shelite, Thomas, 190.25 Schneider, David, S154 Sebastian, Aimy, 75.24 Sepahi, Ali, 73.5 Shalek, Alex, S6 Shelton, Tara, 192.19 Schneider, Elizabeth, Seberll, Thomas, 51.6 Separovic, Lea, 130.18 Shallberg, Lindsey, Shemesh, Itay, 193.1 57.15 Seder, Robert, 139.3, Seraf´ın-Lopez,´ Jeanet, 122.5, 190.11 Shen, Chao-Bin, 183.6 Schoeb, Trenton, S158 190.86 Shamskhou, Elya, Shen, Hao, 66.1 192.20 Sedlacek, Abigail, Serdyuk, Yana, 120.18 119.14 Shen, Lisong, 69.17 Schoenberger, 59.10 Sereti, Irini, 182.88 Shan, Lianyu, 190.21 Shen, Rongfong, 64.7 Stephen, 71.14, Sedy, John R., 129.13 Serezani, Carlos, Shang, Zifang, 197.26 Shen, Xiao, 182.44 134.1 Seely, Spencer, 190.29 117.20, 185.14 Shankar, Archana, Shen, Yufeng, 129.8 Schoenhals, Jonathan, Sefik, Esen, 129.9 Serezani, Henrique, 196.30 Shen, Yujuan, 190.83 136.11 Segal, Benjamin, 64.4, 183.17 Shankar, Malini, 118.8 Sheng, Huiming, 57.10 Schoenherr, Elleanour, 190.14 Serody, Jonathan, Shankarkumar, Aruna, Shenoy, Anukul, 66.22 67.19 Segal, Brahm, 137.13 69.10, 195.18 177.11 Shepherd, Laura, Schoettle, Louie, 131.21 Seger, Philip, 66.11 Serody, Jonathon, Shanker, Anil, 136.18 190.59 Schoettle, Louis, 130.13 Seidman, Jason, 59.2, 69.42 Shannon, John, 56.19, Shepherd, Nicole, Scholl, Kathryn, 119.1 187.21 Serra, Pau, 132.17 66.14, 75.18 140.21 Scholl-Buergi, Sabine, Seki, Noriyasu, 132.1 Serreze, David, 50.6, Shao, Kun, 132.17 Sher, Alan, 124.13, 56.10 Seliga, Alecia, 132.9 50.9, 115.5, 115.8, Shao, Liang, 194.13 190.78 Schrankel, Catherine, Selin, Liisa, 74.7 115.15 Shao, Qi, 138.3 Sher, Taimur, 71.12, S26 Sell, Amanda, 137.11 Sethi, Ashu, 65.3, Shao, Wenhai, 59.8 71.13 Schrantz, Nicolas, Sellers, Brian, 63.4 191.11 Shao, Zhifei, 68.7 Sherafat, Elham, 70.13 126.38 Selvaraj, Periasamy, Setliff, Ian, 72.7 Shapiro, Michael, Shereck, Evan, 76.16 Schreiber, Robert, 70.7, 71.2 Sette, Alessandro, 57.4, 53.17, 68.16, 135.8 Sheriff, Dauda, 61.6 177.23 Selvaratnam, Johanna, 70.16, 76.12, 120.20, Shapiro, Virginia, 56.15 Sherman, Linda, 50.5, Schreurs, Ann-Sofie, 53.14 120.23, 130.20, Sharland, Alexandra, 140.8 182.13 Seman, Brittany, 59.13, 130.26, 131.16, 57.20, 186.11 Sherman, Matthew, Schrum, Adam, 68.18, 190.18 131.20, 131.27, Sharma, Alpana, 195.25 195.24 Semenova, Nina, 64.10 134.11, 140.11, 115.11 Sherr, David, 193.13 Schuettpelz, Laura, Semidey-Hurtado, Jon, 140.14, 186.6, 190.50, Sharma, Anisha, 121.5 Sherve, McKenna, 118.3 194.42 190.78, 196.12 Sharma, Bhesh, 187.5 207.1

163 AUTHOR/SPEAKER INDEX

Sheth, Mili, 139.17 Shlomchik, Mark, Sieck, Gary, 190.19 Singh, Aparajita, 194.26 Skountzou, Ioanna, Shevach, Ethan, 51.4, 121.13 Siefker, David, 124.5, Singh, Baljit, 119.30 126.28 57.7, 57.17, 69.15, Shmiedel, Benjamin, 198.11 Singh, Brenal, 126.1 Skowron, Patryk, 194.41 116.13, 124.8, 130.2, 131.18, 186.6 Sieg, Scott, 136.7 Singh, Divya, 131.18, Slade, Chris, 128.15 194.4 Shollenberger, Lisa, Siegel, Paul, 73.8 182.27 Sladek, Jessica, 66.16 Shi, Guilan, 136.2, 131.10 Siemer, Ramona, Singh, Gagan, 51.13 Slaughter, Joseph, 194.25 Shores, Lucas, 56.19 134.15, 194.26 Singh, Gurkirat, 75.21 138.3 Shi, Guixiu, 182.2 Shornick, Laurie, 127.9, Sierra, Gloria, 70.15 Singh, Harinder, 188.19 Slisarenko, Nadia, Shi, Lei, 56.4 S30 Siewert, Christiane, Singh, Harjeet, 134.2 126.23 Shi, Lingting, 128.18 Shorokhova, Violetta, 130.27 Singh, Jaskirat, 130.23 Sliz, Anna, 181.26 Shi, Pei-Yong, 197.13 120.18 Sika-Paotonu, Dianne, Singh, Jaspreet, 183.12 Small, Annabelle, Shi, Wei, 72.6, 125.18 Shotts-Schroeder, 61.11, 61.14, 61.15, Singh, Narendra, 183.4 126.34 Shi, Xuanling, 197.22 Kristin, 179.14 61.16, 61.17, 61.18, Singh, Nevil, 56.14 Smalling, Rana, 185.10 Shibasaki, Yasuhiro, Shouval, Dror, 67.12 61.19, 61.20, 130.34, Singh, Parul, 125.5, Smelkinson, Margery, 121.17 Shresta, Sujan, 140.5, 130.37, 130.38, 125.15, 190.57 128.6 Shibuya, Rintaro, 140.15, S199 182.80 Singh, Prashant, Smibert, Peter, 130.4 126.33 Shrestha, Binu, 196.19 Silberger, Daniel, 117.19 Smider, Vaughn, S26 Shiferaw, Ayalnesh, Shrestha, Pradeep, 124.10 Singh, Rajbir, 192.4 Smith Shapiro, Virginia, 76.6 69.1, 71.6 Siliciano, Robert, Singh, Rajesh, 181.13 68.16 Shifrut, Eric, 130.6 Shu, Qiang, 122.4 177.18 Singh, Rajinder, 133.7 Smith, Amber, 74.11 Shillova, Nita, 67.5, Shuai, Zongwen, 179.3 Silk, Ann, 136.6 Singh, Ram, 126.8, Smith, Carson, 121.16 190.80, 196.9 Shubin, Nicholas, 54.1, Silk, Tarik, 134.13 132.10, 182.73, Smith, Deandra, 62.6 Shim, JaeHyuck, 126.2 Silva Angulo, Fabiola, 182.76 Smith, Fauna, 75.25 179.12 Shufesky, William, 62.12 Singh, Selina, 192.21 Smith, Keith, 52.1 Shimada, Kenichi, 67.1, 133.6 Silva, Anushka, 135.4 Singh, Shree, 196.10 Smith, Kenneth, 52.14 187.17 Shui, Jr-Wen, 62.18, Silva, Emanuelly, Singh, Sneha, 127.19 Smith, Loretta, 190.1 Shimizu, Chisato, 191.11 136.10 Singh, Sukhvinder, Smith, Margaret, 182.61 Shukla, Manisha, Silva, João, 52.23, 120.3 190.24 Shimizu, Takao, 182.42 190.32 140.20, 190.22 Singh, Sukhwinder, Smith, Mindy, 56.11 Shimizu, Yoji, 138.3 Shukla, Rhythm, 127.14 Silva, Raquel, 181.12 51.2 Smith, Nicole, 66.22 Shimizu, Yui, 194.24 Shukla, Sudhanshu, Silva, Silvano, 128.19 Singh, Tej Pratap, Smith, Paul, 134.13 Shimodaira, Yosuke, 116.15 Silva-Miranda, Mayra, 183.21 Smith, Susan, 182.69 129.6 Shukla, Supriya, 64.24 190.86 Singh, Udai, 138.9 Smith, Timothy, 136.21 Shimojo, Guilherme, Shukla, Vipul, 123.15 Silver, David, 122.3 Singh, Udai P. Singh, Smith, Tyler, 71.8 182.82 Shulten, Veronique, Silver, Phyllis, 193.1 185.4 Smith, Wesley, 131.33 Shin, Eui-Cheol, 120.8, 186.6 Silvestre, Isabel, 126.39 Singh, Vipul, 62.14, Smith-Gagen, Julie, 136.13, 195.2, S91 Shultz, Leonard, 126.37 Sim, Kyu Young, 120.10 182.50 Shin, Eui-Chul, 189.15 Shum, Eleen, 60.19 182.85 Singh, Vishal, 59.3 Smits, Sander, 127.8 Shin, Hyun soo, 118.4, Shum, Thomas, 71.9 Sim, Malcolm, 177.24 Singha, Santiswarup, Sneller, Michael C., 119.24, 177.4, 177.13 Shuman, Stewart, Simms, Colin, 52.5 132.17 72.13 Shin, Hyun-Jin, 73.12 197.8 Simon, Alex, 194.30 Sinha, Sushmita, 57.11, Snook, Jeremy, 136.1 Shin, Kwang-Soo, 70.6, Shun, Chia-Tung, Simon, Scott, 51.13, 57.13, 182.11 Snook, Kirsten, 190.59 195.15 117.12 64.13 Sirenko, Oksana, 51.20 Snow, Andrew, 60.9, Shin, Min Sun, 181.22 Shwetank, ., 181.25 Simons, Diana, 138.17, Siska, Peter, 137.1 184.5 Shin, Myungsun, 71.7 Shyu, Chi-Ren, 195.24 138.21 Sisouvanthong, Chad, Snyder, Annelise, 58.2 Shin, Soomin, 196.30 Siak, Jay, 120.26 Simpson, Destiny, 131.37 Snyder, Deann, 127.12 Shin, Sunny, 62.1 Sibley, L., 177.23 53.24 Sivangala Thandi, Snyder, Greg, 195.25 Shin, Yoo-Sub, 196.25 Sidar, Barkan, 51.6 Sims, Peter, 60.5 Ramya, 66.15, 66.18, Snyder, Julia, 64.2 Shindler, Kenneth, Siddique, Imteaz, Sinclair, Jan, 52.14 181.19 Snyder, Mark, 60.5, 126.17 131.40 Sindi, Suzanne, 65.5 Sivignon, Adeline, 67.21 Shirazi, Roksana, Siddiqui, Sana, 61.12 Singarapu, Maneendra, 192.3 Snyder, Michelle, 61.1, 58.13, 120.25 Sidiq, Tabasum, 64.20, 120.13 Sjolander,¨ Anders, 190.70, S30 Shirley, James, 192.13 190.31 Singel, Kelly, 137.13 130.35 Snyder-Cappione, Shirwan, Haval, 69.1, Sidney, John, 57.4, Singer, Durga, 118.6 Skadow, Mathias, 57.7 Jennifer, 120.6 71.6 70.16, 76.12, 120.23, Singer, Katrin, 137.1 Skak Schøller, Amalie, Soberman, Roy, 186.12 Shissler, Susannah, 134.11, 140.14 Singer, Meromit, 137.15 129.2 Socha, Piotr, 73.10 194.45 Sidorov, Sviatoslav, Singh, Kailash, 182.47, Skakuj, Kacper, 70.12 Soedel, Ashleigh, 136.1 Shiva, Sruti, 125.12 62.7 182.53 Sklavanitis, Brandon, Sohn, Moah, 118.4, Shivagouda Patil, Sidwell, Tom, 125.18 Singh, Akhilesh, 67.24, 194.35 119.24, 177.4, 177.13 Veena, 140.4 Siebenlist, Ulrich, 60.4 189.16 Skopelja-Gardner, Sohn, Seonghyang, Shive, Carey, 120.32 Siebert, Nadja, 68.12 Singh, Anurag, 136.27 Sladjana, 182.26 117.24

164 AUTHOR/SPEAKER INDEX

Soiffer, Robert, 69.42 Sorrentino, Dario, Srivastava, Ruchi, Stewart, Taryn, 190.29 Su, Helen, S39 Sojar, Hakimuddin, 182.30 196.3 Stewart, Elizabeth, Su, Hua, 76.16 120.16 Sosa Hernandez,´ Srivastava, Saurabh, 134.14 Su, Lishan, 71.20, 75.1, Sok, Devin, 72.8 V´ıctor, 179.8 130.5 Stewart, Isabel, 115.5 197.4 Sokke Umeshappa, Soto, Hortensia, 128.20 Srivatsa, Sriram, 192.8 Stienne, Caroline, Su, Maureen, S16 Channakeshava, Sottile, Rosa, 76.3 Srour, Hayat, 55.18 129.13 Su, Min, 68.8, 116.3 132.17 Soulillou, Jean-Paul, St. John-Williams, Lisa, Stier, Matthew, 181.15 Su, Yale, 59.17 Sokol, Caroline L., S141 70.14 56.10 Stiles, Robert, 195.24 Su, Zhaoliang, 60.1, Solang,¨ Charlotte, Souriant, Shanti, 190.79 Staback, Franklin, Stoddard, Jennifer, 135.11 182.53 Soussi-Gounni, 116.15 76.16 Suarez, Lina, 178.4 Soliman, Eman, 187.20 Abdelilah, 190.21 Stadler, Patrizia, 52.21 Stoffel, Kevin, 69.36, Suarez, Yaravi, 73.21 Solis, Norma, 190.4 Southern, Brian, 58.4, Stadnisky, Michael, 126.27 Suarez-Ramirez, Soloff, Adam, 187.23 127.7 130.29 Stohl, William, 129.5 Jenny, 60.17, 66.24 Solouki, Sabrina, 140.1, Soveg, Frank, 127.15 Stadtmueller, Beth, Stolley, James, 189.9 Subramanian, Gayatri, 189.11 Spann, Nathanael, 177.6 Stolley, Michael, 57.18, 75.10 Solt, Laura, 68.6, 68.11, 59.2, 187.21 Stafford, Phillip, 197.18 194.6 Subramanian, Naeha, 183.10 Sparkes, Amanda, 71.5 Stagg, John, 136.24 Stone, Colleen, 115.10 59.6, 63.13 Somasundaram, Sparrelid, Ernesto, 51.5 Stalter, Lily, 52.9 Stone, Everett, 137.11 Subramanian, Ashwin, 195.9 Spartz, Ellen, 134.9 Stambas, John, 130.19 Stone, Sara, 51.10 Subbaya, 194.15 Somerville, John, Spear, Camarie, 53.21 Stamps, Jamsine, Storkus, Walter, 194.27 Suchi, Mariko, 192.21 138.11 Spector, Stephen, 129.6 Stowe, Ann, 182.55 Suchy, James, 195.11 Sommer, Miriam, 62.13 Stan, Radu, 56.19 Strake, Brandy, 57.9 Sue, Lishan, 66.5 182.51 Speir, Mary, 59.4 Standiford, Miranda, Strandt, Helen, 70.23 Sugahara, Kunio, 132.1 Somsouk, Ma, 192.8 Speiser, Daniel, 194.3 180.1 Strange, Daniel, 197.13 Sugiura, Yuki, 56.2 Son, YoungMin, 60.2, Spekker-Bosker, Katrin, Stanford, Marianne, Stras, Stephanie, 67.12 Suhail, Hamid, 183.12 135.28 190.62 70.2 Stratmann, Thomas, Suin, Jing, 124.4 Sonia, 127.4 Spencer, Charles, Stanton, Rebecca, 180.20 Sujino, Tomohisa, Song, Kejing, 182.81 126.20 187.23 Straub, Adam, 59.7 129.15 Song, Boyeong, 70.6, Spencer, David, 72.9 Starenki, Dmytro, 195.7 Strbo, Natasa, 126.31 Sukovich, David, 195.15 Sperling, Anne, 67.22, Stateman, Ariel, 55.18 Strebhardt, Klaus, 184.4 131.13 Song, Christina, 181.28 119.25 Staubert,¨ Claudia, 59.5 Strewe, Claudia, 182.15 Sule, Gautam, 178.1 Song, Hao, 197.26 Sperrazza, Stephanie, Steele, Chad, 55.15, Strickland, Ashley, Sullam, Paul, 130.5 Song, Hye-Won, 60.19, 133.13 190.8 59.15 Sullenger, Bruce, 136.9 131.35 Spidlen, Josef, 130.29 Steeno, Greg, 130.36 Strobel, Sarah, 59.5 Sullivan, Kelly, 52.1, Song, InYoung, 74.7 Spiess, Christoph, Steffens, Nora, 126.6, Strober, Warren, 181.10 Song, Jianxun, 56.1 131.19 127.8 120.26 Sullivan, Patrick, Song, Jikui, 127.20 Sredni, Benjamin, 193.1 Stegman, Molly, 190.34 Strodel, Birgit, 127.8 182.25 Song, Jin Yong, 187.11 Sreekumar, Bharath, Steinel, Natalie, 73.7 Stromnes, Ingunn, Sullivan, Peter, 71.16 Song, Kejin, 192.1 64.3, 124.6, 124.11, Steinert, Elizabeth, 134.9 Sultan, Muthanna, Song, Meredith, 138.3 128.8, 188.7 66.21 Strutt, Tara, 66.19, 74.2 183.14 Song, Nianbin, 177.14, Srikanth, Sonal, 63.3 Steinman, Lawrence, Struve, Carsten, 192.3 Sumida, Cara, 194.12 177.25 Srinivasa Murthy, 52.15 Stuart, John, 133.18 Sumida, Hayakazu, Song, Qingxiao, 69.11 Satyapramod, 196.13 Steinmetz, Nicole, Stubbington, Michael, 182.42 Song, Sihong, 132.12 Srinivasamani, 136.7 131.4, 131.13, 194.29 Summers, Daniel, 64.1 Song, Wenxin, 58.5 Anupallavi, 185.2 Stein-Thoeringer, Stubelius, Alexandra, Summers, Scott A., Song, Ying-Chyi, 193.6 Srinivasan, Christoph, 69.34 125.1 185.10 Song, Yinhong, 136.12 Madhuwanti, 71.8 Stephens, Laura, Studer, Sean, 196.6 Sumpter, Steilan, 183.4 Song, Yuan, 69.7, Srinivasan, Mythily, 139.11 Studstill, Caleb, 74.10, Sumpter, Tina, 54.5, 135.10 182.54 Stephens, Robin, 197.5 133.6 Song, Yuleum, 74.10 Srinivasan, R. Sathish, 190.28 Stumhofer, Jason, Sun, Bing, 64.22 Sonsalla, Shelly, 70.5 180.16 Stephenson, Sophie, 190.75 Sun, Binggang, 130.24, Soon, Sioe Fei, 186.1 Sriram, Krishna, 122.15 123.7, 123.23 Stumpel,¨ Jan Phillip, 130.25, 194.40 Soong, Lynn, 190.25, Sriram, Uma, 132.9 Stepniak, Dariusz, 198.12 Sun, Bo, 124.2 190.37 Srivastav, Sudesh, 126.38 Sturgill, Ian, 126.27 Sun, Cheng, 195.4 Soper, Brian, 182.67 122.2 Stern, Lawrence, 177.9, Sturtz, Alexandria, Sun, Guoqing, 75.12 Soper, David, 184.6 Srivastava, Amitabh, 177.21, 177.28 190.26 Sun, Hongwei, 140.2 Sorci, Leonardo, 52.2 124.14 Sternberg, Luise, Su, Andrew, 120.33 Sun, Hui-lung, 53.19 Sorg, Ursula, 190.87 Srivastava, Pramod, 120.23, 134.1 Su, An-Jey, 69.46 Sun, Jiaren, 75.4, Sorini, Chiara, 178.8 58.15, 70.13 Steven, Cate, 71.15 Su, Chen, 184.8 190.37 Soroosh, Pejman, Srivastava, Rajneesh, Stevens, James, Su, Dongming, 53.8, Sun, Jie, 60.2, 74.5, 51.12, 122.10 69.6 139.17 68.1 129.18, 135.28

165 AUTHOR/SPEAKER INDEX

Sun, Joseph, 63.15, Svatek, Robert, 136.14 Tai, Joyce, 182.26 Tang, Yilang, 181.4 Teijaro, John, 121.4, 76.3, 76.9, 187.8, S78 Svensson, Valentine, Tajti, Gabor, 131.9 Tang, Ying, 192.13 140.8 Sun, Joshua, 196.28 186.1 Takahashi, Daisuke, Tangye, Stuart, 74.12 Tekkam, Srinivas, 60.12 Sun, Mengxi, 65.10 Svensson-Arvelund, 191.4, 191.11 Tanno, Hidetaka, 71.15 Telfer, Janice, 73.23 Sun, Ren, 62.8, 63.3 Judit, 136.4, 136.19 Takahashi, Kazuko, Tantin, Dean, 115.10, Tellez-Frietas, Claudia, Sun, Rui, 195.20 Svoronos, Nikolaos, 183.16 186.3 196.16 Sun, Shaocong, 64.12 138.22 Takahashi, Naofumi, Tanveer, Ammar, Telmer, Cheryl, 135.5 Sun, Shao-Cong, Swain, Pamela, 56.16 126.23 197.18 Teng, Don, 74.12 135.14 Swain, Steve, 59.16 Takahashi, Riichi, Tanwar, Shalini, 51.4 Teng, Xiangyu, 132.6 Sun, Xiaoli, 59.2 Swain, Susan, 140.10, 129.15 Tao, Mi-Hua, S79 Teng, Xiu, 52.10, 59.1, Sun, Xin, S141 198.5 Takahashi, Takeshi, Tao, Ying, 182.29 117.9, 182.74 Sun, Xinghui, 115.3, Swanson, Joel, 125.14 131.31 Tao, Zhihua, 71.19 Tenner, Andrea J., S48 180.19 Swanson-Mungerson, Takamori, Ayako, 54.8 Taplitz, Randy, 120.20 Terabe, Masaki, 134.8 Sun, Xinguo, 182.33 Michelle, 133.13 Takamura, Shiki, 129.2 Tarakanova, Vera, Terada, Lence, 69.30 Sun, Xiujie, 195.16 Swanstrom, Ronald, Takasato, Yoshihiro, 75.3, 75.9 Terkeltaub, Robert, Sun, Xizhang, 182.26 197.14 54.3 Tareen, Semih, 133.2 125.1 Sun, Yaping, 56.6 Swarts, Jessica, 57.8 Takayanagi, Hiroshi, Targ, Sasha, 123.22 Teryek, Matthew, 189.8 Sun, Ying, 179.3 Swartwout, Brianna, 189.3 Tarleton, Rick, 190.60 Tesar, Peter, 182.69 Sun, Zuoming, 124.1 178.10, 178.11 Takazawa, Ikuo, 53.3, Tarr, Phillip, 126.3 TeSlaa, Tara, 137.1 Sunagar, Raju, 139.6 Swartz, Adam, 70.20 124.3 Tartey, Sarang, 64.25 Testerman, Traci, Sundrud, Mark, 68.11 Swartz, Melody, 133.5, Takeda, Kazuyo, Taruselli, Marcela, 185.4, 190.30 Sundstrom,¨ Patrik, 196.20 139.20 185.5 Teuscher, Cory, 178.3 138.13 Swartzendruber, Julie, Takeuchi, Tsutomu, Tasker, Carley, 66.5 Texari, Lorane, 187.21 Sung, Alexander, 119.11 132.1, 182.23 Tatomir, Alexandru, Teyton, Luc, 120.33, 182.50 Sweazey, Robert, 165.1 Takizawa, Fumio, 52.4, 132.3 S78 Sung, Jiaren, 190.25 Sweeney, Shannon, 121.17 Tatsumi, Naoya, 56.9 Tezza, Sara, 193.13 Sung, Julia, 197.14 125.1 Talay, Oezcan, 119.5 Tauber, Rebecca, Thaker, Youg Raj, Sung, Myong-Hee, Sweet, David, 64.24 Talbot, Guylaine, 73.13 131.16 184.4 125.17 Swidergall, Marc, 190.4 Talbott, George, 194.12 Taubert, Stefan, 64.6 Thalhamer, Josef, Sung, Sun-Sang, 132.3 Swieboda, Dominika, Talley, Sarah, 69.37 Tavares, Lucas, 190.22 70.23 Sung, Young Chul, 126.28 Talmadge, James, Taves, Matthew, 53.12 Thangavelu, 189.15 Swiecki, Melissa, 57.9 135.15 Tayade, Chandrakant, Govindarajan, 69.10 Sungur, Pelin, 59.5 Syed, Fahim, 140.21 Talpos-Caia, Ana, 132.3 182.19 Thapa, Puspa, 60.5, Sunyer, J. Oriol, 121.17 Sykes, David, 70.19, Talukdar, Priyanka, Taylor, Savannah, 67.21, 122.13, 129.8 Suresh, M., 70.5, 127.22 62.2 195.25 Thaventhiran, James, 190.17 Sykes, Stephen, 118.2 Talwar, Harvinder, Taylor, Alison, 136.24 52.14 Suryadevara, Naveen Sykulev, Yuri, 130.21 52.12 Taylor, Austin, 56.6 Theall, Brandon, 121.2, Chandra, 73.2 Symons, Antony, 68.7 Tam, Christine, 132.4 Taylor, Christopher, 121.5, 128.6 Suryadevara, Szabo, Peter, 60.5, Tam, Eric, 195.11 193.2 Theisen, Derek, 177.23 Naveenchandra, 60.6 129.8 Tam, Jason, 64.12 Taylor, Gregory, 126.35 Thelen, Kyan, 73.11 Suryawanshi, Amol, Szabolcs, Paul, 69.5 Tam, Miguel, 128.20 Taylor, Ian, 60.19, Thiault, Nicolas, 53.3, 55.16 Szanto, Tibor, 131.9 Tamagnone, Luca, 130.29, 131.35, 129.7, 140.4 Sustar, Vid, 177.12 Szasz, Taylor, 117.14 186.4 189.18 Thiel, Jens, 53.18 Suthar, Mehul, 196.7 Sze, Sing-Hoi, 190.31 Tan, Haiyan, 53.19 Taylor, Jared, 63.1 Thiessen, Nina, 194.41 Suto, Eric, 132.4 Szeponik, Louis, 138.14 Tan, Marietta, 70.11, Taylor, Jennifer, 194.27 Thomas Babu, Sarah, Sutoh, Yoichi, 73.1 Szeto, Gregory, 132.15 196.21 Taylor, Julia, 121.11, 66.4 Sutton, Caroline, Szybut, Clare, 130.30 Tan, Tse-Hua, 124.7, 123.14, 195.6 Thomas, Bolaji, 73.17 125.11 Szymczak-Workman, 132.2, 191.8, S79 Taylor, Michael, 194.41 Thomas, James, Sutton, William, 72.9 Andrea, 184.1 Tan, Yin Fei, 118.2 Taylor, Patricia, 69.10 115.14 Suwankitwat, Tan, Zhiwu, 195.13 Taylor, Ryleigh, 198.11 Thomas, Lisa, 129.6 Nutthakarn, 64.18 Tanaka, Lena, 182.26 Taylor, Sarah, 131.4, Thomas, Muriel, 66.2 Suzuki, Fujio, 126.13, T Tanaka, Yuki, 126.1 131.13, 194.29 Thomas, Paul, 74.6, 187.25 Tabdili, Yasmine, Tang, Alice, 184.8 Taylor, Tiffany, 186.13 74.12, 134.14, 136.6 Suzuki, Hiromichi, 177.18 Tang, Chao, 194.18 Tchaicha, Jeremy, Thomas, Rachel, 53.8, 194.41 Tabib, Tracy, 177.8 Tang, Huanyu, 69.44 137.3 68.1 Suzuki, Katsuya, 132.1, Tacke, Robert, 196.28 Tang, Jihong, 191.6 Tcyganov, Evgenii, Thomas, Rajan, 69.23, 182.23 Tada, Yuma, 135.7 Tang, Lydia, 140.19 137.12 182.65 Suzuki, Masataka, Taffet, Steven, 58.19 Tang, Rong, 115.13 Tector, Mathew, 69.27 Thomas, Ranjeny, 129.15 Tagami, Yaeko, 190.59 Tang, William, 140.15 Tectro, Joseph, 69.27 69.38 Suzuki, Sumihiro, Tahimic, Candice, Tang, Yangyang, Teichmann, Sarah, Thomas, Seddon, 192.15 182.13 130.40 186.1 117.1, 119.23

166 AUTHOR/SPEAKER INDEX

Thomas, Terry, 58.3, Tiwari, Shashi, 185.1 Torres-Lopez,´ Javier, Tsai, Chih-Ming, 185.1 Tyner, Jeffrey, 195.10 71.3, 130.14, 130.18 Tiwari-Heckler, Silpa, 190.81 Tsai, Mindy, 126.2 Tyring, Stephen, Thomas, Wendy, 63.12 182.43 Torres-Ruiz, Jiram, Tsay, Gregory J, 182.34 140.17, 179.2, 182.15 Thomassen, Mary, Tiwary, Meenakshi, 179.7, 179.8 Tse, Hubert, 63.1, Tyurin, Vladimir, 58.18 120.21, 187.20 198.6 Torres-Velez, 69.19, 178.7 Tyznik, Aaron, 131.37 Thompson, Brooke, Tiziani, Stefano, 125.1 Fernando, 66.25 Tseng, Chien-Te, 119.30 Tkacheva, Olga, 133.6 Toth, Marta, 129.8 139.10 Thompson, Emily, 66.21 Tlacuilo, Alberto, 135.24 Touchette, Vincent, Tseng, Yung-Chieh, U Thompson, J. Will, 56.10 To, Tsun, 135.7 190.67 139.21 Uberti, Benjamin, 73.19 Thompson, Lucas, Todd, Alexandra, 139.1 Touma, Danielle, 58.14 Tsetkov, Andrey, 62.14 Uche, Ifeanyi, 198.13 195.32 Todd, Betsy, 117.14 Tourdot, Sophie, Tsiagbe, Vincent, 60.20 Uchiyama, Satoshi, Thompson, Paul T., Todd, John-Paul, 72.6 130.36 Tsiganov, Evgenii, 196.28 124.2 Toka, Felix, 64.11 Townsend, Dana, 194.2 Udartseva, Olga, 194.9 Thomsen, Allan, 129.2 Tokarz, Debra, 187.20 197.21 Tsintzas, Dionysios, Uddback, Ida, 129.2 Thomsen, Emil, 66.12 Tokmina-Lukaszewska, Toy, Randall, 196.7 119.2 Udden, Sm, 194.44 Thoner, Tim, 189.14 Monika, 180.8 Traba, Javier, 121.2, Tsu, Brian, 197.20 Ufermann, Christoph- Thorne, Amy, 70.4 Tokmina-Roszyk, 121.5, 128.6 Tsuchimoto, Yusuke, Martin, 190.62 Thornthwaite, Jerry, Dorota, 56.3, 180.8 Tracey, Kevin, 133.17 120.14, 195.14 Ugur, Zeynep, 66.24 120.29 Tokunaga, Katsushi, Trageser, Nicholas, Tsuda, Hidetoshi, 69.16 Uhrlaub, Jennifer, 121.9 Thornton, Angela, 57.7, 177.10 182.70 Tsuha, Avery, 126.2 Uiese, Tina, 61.11, 116.13 Tokunaga, Keli, 182.50 Tram, Cynthia, 70.2 Tsukahara, Narutoshi, 61.14 Thota, Rukman, 134.1 Tolentino, Miguel, Tram, Van Thi Ngoc, 130.32 Ukah, Tobechukwu, Thounaojam, Menaka, 193.16 120.34 Tsung, Allan, 135.2 181.1 136.18 Tollefson, Sharon, Tran, Danh, 137.5 Tu, Chia-Hung, 117.12 Ulezko Antonova, Alina, Thovarai, Vishal, 191.6 198.10 Tran, Dat, 193.2 Tu, Sha, 115.13 69.41 Thrum, Stephan, Toma, Clara, 60.14, Tran, Giang, 57.20, Tu, Wenwei, 140.18 Ulloa, Luis, 182.82 182.51 138.6, 189.12 116.16, 186.11 Tuan, Chih-Hsuan, Ulrich, Benjamin, Thurman, Christina, Tomalka, Jeffery, Tran, Holly, 62.10 138.8 119.13, 128.5, 128.14 178.17 116.15 Tran, Vuvi, 190.55 Tuazon, Jasmine, 76.7 Ulrich, Peaches, Thurman, Joshua, S6 Tomalka, Jeffrey, 51.21 Traore, Boubacar, Tuder, Rubin, 182.68 130.13, 131.21 Thurmond, Stephanie, Tomaso, Tony d., S26 126.7, 190.45 Tumanov, Alexei, 67.8 Unanue, Emil, 116.5, 127.20 Tometich, Justin, Trauth, Amy, 61.1 Tumuluru, Sravya, 180.5 Thwe, Phyu, 64.2 192.10, 198.2 Treeful, Amy, 73.9 135.21 Unuvar Purcu, Duygu, Tian, Di, 71.20 Tomic-Canic, Marjana, Trembath, Andrew, Tuna, Kubra, 192.13 187.22 Tian, Fenghua, 182.55 126.31 115.16 Tung, John-Paul, 182.69 Upadhyay, Chitra, Tian, Xiangjun, 193.2 Tominello, Tyler, Tremoulet, Adriana, Tuo, Wenbin, 127.16 197.17 Tian, Yuan, 140.11 190.51, 190.63 182.61 Tuomilehto, Jaakko, Upadhyay, Ranjan, Tian, Zhigang, 195.4, Tomita, Beverly, 124.2 Trent, Brandon, 190.25, 181.18 70.9, 138.19 195.20 Tomolonis, Julie, 190.37 Turan, Aslihan, 196.4 Urano, Emiko, 74.15 Tiburzi, Olivia, 68.15 195.27 Trezise, Del, 130.30 Turatti, Aline, 52.23 Urban, Stina, 117.4 Tieu, Tam, 187.18 Tonc, Elena, 53.23 Tridandapani, Turk, Mary Jo, 135.17, Urdahl, Kevin, 72.10, Tikoo, Shweta, 122.11 Tong, Chenxi, 136.12 Susheela, 59.12 138.1, S17 185.1 Tilstam, Pathricia, 51.9, Tong, Li, 120.24 Trinchieri, Giorgio, Turley, Alexandra, 55.3 Uruno, Takehito, 185.12 180.13 Tonui, Joan, 190.39 69.38, 190.1, 191.12 Turnbull, Bryan, 74.3 Utley, Adam, 123.11 Ting, Jenny, 64.12, Toor, Jugmohit, 130.4, Tripathi, Deepak, 66.15, Turnbull, Isaiah, 118.3 Utzschneider, Daniel, 197.4 177.31 66.18, 181.19 Turner, Jackson, 125.14 140.16 Tinoco, Roberto, 140.6 Toothaker, Jessica, Tripp, Ralph, 127.21, Turner, Joanne, 62.3 Uwiera, Richard, 192.19 Tippalagama, Rashmi, 67.12 130.19, 198.1 Turner, Lucas, 122.17 Uyttenhove, Catherine, 120.20 Tooze, Reuben, 123.7, Tritz, Zachariah, 56.20 Turner, Stephen, 60.11, 136.23 Tiriveedhi, 123.23 Trivedi, Sheetal, 196.13 125.6, 189.1, 196.27 Uzel, Gulbu, 76.16 Venkataswarup, Toro, Jessica, 177.1 Trivett, Anna, 68.17 Turnquist, Heth, 69.28, Uzonna, Jude, 190.21 70.10 Torosian, Leona, 135.4 Troilo, Arianna, 53.18, 69.35, 118.14, 125.12 Tirouvanziam, Torrelles, Jordi, 62.3, 129.12 Tuttle, Kathryn, 181.10 Rabindra, 183.15 62.20 Troutman, Ty, 59.2, Tuvim, Michael, 66.3 V Tisch, Roland, 68.14 Torres Santiesteban, 187.21 Tvinnereim, Amy R., Vacharathit, Vimvara, Titov, Anton, 66.19, Gretel, 135.17 Trtiz, Zachariah, 76.2 181.19 52.13 132.6 Torres, Annabel, 184.8 Trudeau, Louis-Eric, Tward, Aaron, 129.1 Vadlamudi, Ratna, Tivitmahaisoon, Torres, Kevin, 137.4 177.27 Tweed, Jefferson, 195.5, 195.6, 195.29 Parcharee, 119.5 Torres, Raul, 179.14 Truman, Richard, 73.2 182.55 Vaillant, Maud, 179.6 Tivon, Yaniv, 71.18 Torres, Vaneesa, Truong, Danielle, 71.3 Tyler, Christopher, Vainio, Marika, 177.12 Tiwari, Charu, 190.66 182.55 Truong, Phuong, 126.2 67.13 Vaipuna, Kalilea, 61.20

167 AUTHOR/SPEAKER INDEX

Vaipuna, Tevita, 61.11 van der Windt, Dirk, Vella, Anthony, 63.14, Vijaykrishna, Vuerich, Marta, 68.13, Vaishnava, Shipra, 135.2 126.36 Dhanasekaran, 74.12 182.10 67.14, 191.13 Van Endert, Peter, Vella, Jennifer, 138.1 Vijay-Kumar, Matam, Vyas, Kanan, 50.7 Vaitaitis, Gisela, 68.9, 177.5, 177.22 Velu, Vijayakumar, 76.6 59.3, 192.4, 192.9 Vyas, Radha, 184.8 115.4, 182.45 Van Etten, Kathrine, Vemula, Praveen, Vilchis, Armando, Valadkhan, Saba, 60.8 73.21 192.4 118.18 Valanparambil, Rajesh, Van Kaer, Luc, 60.6 Venables, Thomas, Villinger, Francois, 76.6 W 56.6 Van Keulen, Virginia, 65.15, 65.16 Vinay Pandey, Ram, Waddell, Nicola, 69.38 Valantine, Hannah, S88 190.20 Venhoff, Nils, 53.18 65.6 Wadesworth, Marc, Valderrama, Andres, van Oers, Nicolai, Venkatachalam, Violet, Pierre-Christian, 190.41 181.21 120.9, 182.32 Karthikkumar, 66.9 133.11 Wadsworth, Angela, Valdes´ Alvarado, Van Schaik, Erin, Verdaguer, Joan, Virgen-Slane, Richard, 119.5 Emmanuel, 135.24 190.31 180.20 185.16 Waggoner, Stephen, Valdes-Alvarado,´ van Snick, Jacques, Verdeil, Gregory, 194.3 Virgin, Herbert, 177.23 76.7, 76.10, 122.16 Emmanuel, 182.40 136.23 Verdugo-Meza, Visvabharathy, Wagner, Carl, 66.6 Valdez, Yanet, 130.18 Vance, Jordan, 59.13, Andrea, 138.10 Lavanya, 190.5 Wagner, David, 68.9, Valdovino-Gonzalez, 190.18 Vergne, Isabelle, Viswanadhapalli, 115.4, 182.45 Alan, 131.18, 182.27 Vangipuram, Ramya, 190.79 Suryavathi, 195.6 Wagner, Ulf, 59.5, Valeff, Natalin, 123.19 140.17 Verhagen, Andrea, Vita, Alexandra, 133.15 182.51 Valencia, Clint, 118.13 Vankayalapati, 130.5 Vita, Randi, 130.20, Waid, Dan, 68.9, 115.4, Valentin, Anibal, 123.5 Ramakrishna, 66.15, Verma, Navin Kumar, 130.26, 131.16, 182.45 Valentin, Antonio, 72.4 66.18, 181.19 138.12 131.20 Waigel, Sabine, 192.4 Valentine, Kristen, Vann, Lewis, 132.14 Verma, Nirupama, Vithoulkas, George, Wainwright, Derek, 115.17, 115.22 Varadaraj, Archana, 57.20, 116.16, 186.11 119.2 137.2 Valenzuela, Alicia, 194.37 Verma, Richa, 196.10 Vived, Celia, 180.20 Waisman, Ari, 181.4 130.10 Varadarajan, Navin, Verma, Saguna, 197.13 Vizcarra, Edward, Waithman, Jason, Valera, Isela, 182.76 134.2, 134.6 Verollet, Christel, 190.79 140.15 138.2 Valeri, Maria, 190.6 Varelias, Antiopi, 69.38 Verstichel, Greet, 53.3, Vlaisavljevich, Eli, Wakeland, Edward, Valfort, Aurore-Cecile, Varga, Steven, 139.11, 140.4 194.30 120.9 137.7 198.3, 198.7 Vestbostad, Johanne, Vlodavsky, Israel, 52.15 Wakim, Linda, 74.12 Valizadegan, Negin, Vargas, Joselin, 182.48 179.16 Vogl, Wayne, 192.3 Wakita, Daiko, 67.1, 73.21 Varkhande, Suraj, 51.7 Vetizou, Marie, 69.38, Vohra, Naila, 131.12 120.4 Vallance, Bruce, 192.3 Varki, Ajit, 190.46 190.1 Voic, Hannah, 76.12 Wakley, Alexa, 182.63 Valle, Yeminia, 135.24 Varki, Nissi, 130.5, Vezys, Vaiva, 57.18, Voisin, Aurore, 177.27 Waldrip, Zachary, 69.26 Valle-Delgadillo, 181.21 66.21, 194.6 Voisin, Benjamin, 58.12 Waldstein, Kody, 198.3 Yeminia, 182.40 Varney, Melinda, Viajar, Sharon, 131.19 Volfson Sedletsky, Wali, Shradha, 66.3 Valle-Rios, Ricardo, 186.14 Vian, Laura, 181.27 Victoria, 125.2 Walker, Ameae, 137.6 118.18 Varnum, Stella, 187.26 Vick, Sarah, 195.18 Volin, Michael, 133.13 Walker, Christopher, Valli, Eduardo, 125.16, Varriale, Antonio, 52.2 Vickers, Kasey, 116.14 Vollmer, David, 183.18 196.13 139.16 Vasanthakumar, Victor, Lisa, 69.18 Vomund, Anthony, Walker, David, 190.58 Valluri, Vijaya Lakshmi, Ajithkumar, 125.18 Vidal-Pedrola, Gemma, 180.5 Walker, Matthew, 119.3 181.19 Vasudev, Anusha, 179.9 von Lilien Waldau, Walker, Wendy, 64.5 Valujskikh, Anna, 123.14 Vidanagama, Vanessa, 198.12 Wall, Valerie, 180.11 69.14, 69.16, 69.29, Vatan, Linda, 137.11 Dhammika, 120.20 von Moltke, Jacob, Wallace, Callen, 122.3 186.8 Vaughan, Brent, 183.18 Vieira, Ana, 57.2 S141 Wallace, Daniel, 182.8 Van Acker, Aline, Vazquez-meves, Vieira-Brock, Paula, Vong, Allen, 140.10 Waller, Alexandra, 71.2, 187.10 Guelaguetza, 187.35 183.18 Vorholt, Daniela, 194.26 71.17 Van Braeckel-Budimir, Veenbergen, Sharon, Vignali, Dario, 76.7, Vor¨ os,¨ Orsolya, 184.3 Waller, Edmund, 69.41, Natalija, 198.7 56.10 138.15, 195.9, S107 Vos, Duncan, 121.6 69.43, 70.8 Van de Water, Judy, Veerman, Brent, 182.6 Vijay, Rahul, 190.26 Voskoboynik, Katie, Walser-Kuntz, Debby, 130.9 Veglia, Filippo, 58.18 Vijayan, Madhuvanthi, 186.16 187.18 van den Bogaart, Geert, Veiga, Diogo, 117.19 74.10, 197.5 Voss, James, 72.8 Walsh, Craig, 135.4, 117.5, 177.7 Veillette, Andre, 53.21 Vijayan, Saptha, 64.20, Voss, Kelsey, 60.9, 193.10 van den Brink, Marcel, Vela Patiño, Sandra, 190.61 184.5 Walsh, Matthew, 69.34 132.11 Vijayanand, Vozenilek, Aimee, 126.22 van den Elsen, Peter J., Velayutham, Pandurangan, 65.1, 120.35 Walter, Dagmar, 131.4, 64.20 Murugesan, 125.12 65.3, 120.20, 120.23, Vu, Annette, 134.17 131.13 Van der Gracht, Esme, Velazquez,´ Henry, 125.4, 131.18, 131.27, Vu, BaoChau, 59.2, Walter, Fruzsina, 51.8 67.8 55.19 140.4, 140.11, 182.27, 187.21 Wan, Edwin, 115.12 van der Heide, Verena, Velazquez-palafox, 186.6, 190.50, 196.12, Vu, Luan, 124.5, 198.11 Wan, Jie, 60.1 76.1 Miguel, 130.29 S142 Vu, Tam, 130.9 Wan, Jon, 120.10

168 AUTHOR/SPEAKER INDEX

Wan, Jun, 177.16 Wang, Qi-Long, 184.11 Wani, Khursheed, 64.6 Wedel, Johannes, 69.13 Wenzel, Sally, 119.1 Wan, Li, 64.1 Wang, Qiming, 50.6 Ward, Brant, 54.6 Wedemeyer, Heiner, Werbel, Tyler, 126.30 Wan, Qingqing, 57.6, Wang, Qinghong, 55.17 Warda, Katerina, 51.5 Werner, Lael, 67.12 67.3 Wang, Qingling, 130.40 196.17 Weerapana, Eranthie, Wertheim, Joel, 197.20 Wan, Xiaochun, 194.18 Wang, Qingyang, Ware, Carl F., 62.8, 124.2 Wertheimer, Anne, Wan, Xiaoxiao, 116.5, 191.11 129.13, 185.16, Wehr, Claudia, 53.18 140.22 180.5 Wang, Qiuling, 177.23 194.41 Wei, Chungwen, 50.10 West, Erin, 56.10 Wan, Yisong, 128.13 Wang, Ran, 68.11 Ware, Timothy, 71.7 Wei, Haiming, 195.4 Westall, Glen, 74.12 Wanek, Alanna, 192.1 Wang, Rongfu, 51.1 Wargo, Jennifer A., S17 Wei, Hairong, 188.1 Westfall, Sydney, Wang, Qiang, 69.12 Wang, Ruoke, 197.22 Warnatz, Klaus, 53.18 Wei, Ruihua, 133.10 186.14 Wang, Andrew, 131.33 Wang, Shengjun, 60.1 Warneke, Paul, 196.8 Wei, Shuang, 137.11 Wettstein, Peter, Wang, Andy, 134.16, Wang, Shu, 59.4 Warner, Barbara, 126.3 Wei, Xiaoqiong, 52.10, 195.24 194.33 Wang, Shuhua, 70.8 Warner, Marcie, 61.9 59.1, 117.9, 182.74 Wewers, Mark, 62.20 Wang, Bowen, 59.17 Wang, Shuya, 70.12 Warr, Alex, 66.10 Wei, Yingying, 182.29 Weyand, Cornelia, Wang, Boxiao, 127.20 Wang, Song, 183.6 Warren, Joanna, Wei, Yun, 192.8 S168 Wang, Chang, 192.19 Wang, Wei, 185.7 197.14 Weidtkamp-Peters, Whale, Kevin, 123.23 Wang, Chao, 124.14 Wang, Weikan, 53.8, Warren, Sarah, 131.26 Stefanie, 126.6 Whary, Mark, 52.13 Wang, Chaoqun, 129.1 68.1 Waseem, Tayab, Weilhammer, Dina, Wheeler, Daniel, Wang, Chaunmin, Wang, Wei-Le, 53.22 121.14, 122.12, 75.24 131.16, 131.20 57.20, 186.11 Wang, Weili, 132.13 182.75 Weinstein, Arthur, Wheeler, Ryan, S149 Wang, Chuanping, 63.9 Wang, Weimin, 137.11 Washam, Charity, 50.7 182.8 Wherry, E. John, Wang, Chyung-Ru, Wang, Weiwei, 69.17, Washington, Allen, Weirauch, Mathew, 126.22, 189.17 190.5 120.12 181.21 125.13 Whillock, Amy, 123.2 Wang, Esther, 119.25 Wang, WeiWei, 193.7 Washington, Kia, 69.46 Weirauch, Matthew, Whitall, Laura, 179.8 Wang, Fang, 182.48 Wang, Wenjing, 194.16 Washington, M., 117.20 197.11 White, Brandie, 131.18, Wang, Guan, 136.5 Wang,Wenjuan,190.16 Wasik, Brian, 130.5 Weisberg, Andrea, 182.27 Wang, Guixia, 182.18 Wang, Xiantao, 187.1, Wassie, Liya, 190.56 56.19 White, Natalie, 67.7, Wang, Guoshun, 187.2 Watanabe, Masashi, Weiskopf, Daniela, 194.31 187.33 Wang, Xiaoning, 69.11 53.13 76.12, 140.11, 140.14 White, Steven, 67.22 Wang, Haichen, 186.15 Wang, Xiaoxia, 135.3 Waters, Ray, 73.16 Weiss, Kayla, 198.3 White, Theresa, 115.21, Wang, Haifeng, 178.10 Wang, Xin, 57.21 Watford, Wendy, Weiss, Kelly, 119.6 128.16 Wang, Haiguang, 56.13 Wang, Xuan, 181.3 128.15 Weiss, Richard, 70.23 White, Tommi, 68.18 Wang, Haiting, 132.6 Wang, Xue, 127.8 Watkin, Levi, 55.21 Weissler, Katherine, White, William, 187.1, Wang, Hong, 138.16 Wang, Yajing, 195.25 Watkins, Simon, 122.3 182.52 187.2 Wang, Hongsheng, Wang, Yan, 56.8, 128.7 Watowich, Stephanie, Weitkamp, Joern- Whitehead, Gregory, 123.1, 178.2, 179.1 Wang, Yang, 190.12, 135.14 Hendrik, 192.2 117.1, 119.18, 119.23 Wang, Jake, 136.25 190.83 Watson, Ashley, 71.3 Weizman, Orr-El, 76.3, Whitfield, Michael, Wang, Jean, 194.20 Wang, Yi, 197.8 Watson, Ian, 136.24 187.8 182.37 Wang, Jeffrey, 119.9 Wang, Yidan, 75.8, Watters, Aaron, 75.11 Weldon, Caroline, Whitlock, Benjamin, Wang, Jialu, 68.15 140.12 Watts, Tania, 74.9, 52.22, 131.7 76.3 Wang, Jian, 135.14 Wang, Yifei, 59.10 140.7 Wellman, Laurie, Whyte, Julia, 61.19 Wang, Jianyong, Wang, Ying-Ting, 140.5 Watzl, Carsten, S160 182.75 Wichert, Anne, 190.87 131.19 Wang, Yingyun, 134.18 Waugh, Katherine, Wells, Andrew, 69.23, Widmann, Stephanie, Wang, Jinghua, 124.4 Wang, Yitong, 69.41 52.1, 181.10 182.65, 184.8 60.19, 131.35, 131.37 Wang, Jingwei, 121.11, Wang, Yong, 69.46 Weaver, Casey, Wells, Jakob, 190.63 Wiesend, Wendy, 195.6 Wang, Yongan, 55.14 119.14, 124.10 Wellstein, Anton, 195.30 Wang, Jingyi, 178.9 Wang, Yu, 133.7 Webb, Carol, 118.7, 120.24 Wight, THomas, 52.15, Wang, Jocelyn, 182.41 Wang, Yueqiang, 53.1 118.8 Welm, Alana, 195.12 180.11 Wang, Julie, 57.3, Wang, Zeping, 190.4 Webb, Lindsay, 119.6, Welner, Robert, 118.14 Wijewickrama, Ananda, 116.1, 133.1, 133.8 Wang, Zhen, 52.10, 182.60, 186.9 Welsh, James, 136.11 140.11 Wang, Junmei, 189.10 59.1, 117.9, 182.74 Webb, Tonya, 194.43, Welsh, Robin, 177.14, Wijeyesinghe, Sathi, Wang, Ke, 178.16, Wang, Zheng, 60.2 194.45 177.25 189.9, 194.6 180.14 Wang, Zheng-Yu, 69.27 Weber, Daniel, 131.6 Wen, Chiao, 194.38 Wikenheiser, Daniel, Wang, Lei, 194.32 Wang, Zhenping, 54.16, Weber, Jeffrey, 194.5, Wen, Jinsheng, 140.15 190.75 Wang, Lin, 194.5 122.15, 126.30 194.21 Wendoh, Jerome, 72.10 Wiklund, Martin, 131.29 Wang, Liqing, 69.23 Wang, Zhi, 190.64 Weber, K. Scott, 196.16 Weng, Nan-Ping, 65.14 Wikramanayake, Wang, Lisheng, 139.13 Wang, Zhongfang, Weber, Michele, 131.28 Weninger, Wolfgang, Tongyu, 126.31 Wang, Meiying, 182.73 196.27 Wechsler, Michael, 122.11 Wilcox, Paul, 57.20, Wang, Min, 62.4 Wang, Zhuang, 50.4 120.31, 182.83 Wenk, Markus, 122.3 116.16 Wang, Peng, 125.3 Wang, Ziming, 69.36, Wechsler-Reya, Wente-Roth, Traci, Wilder-Kofie, Temeri, Wang, Qi, 197.4 197.12 Robert, 194.41 131.12 190.78

169 AUTHOR/SPEAKER INDEX

Wildner, Sabrina, 70.23 Wondemagegn, Tadlo, Wu, Fengting, 177.18 Xia, Ying, 75.12, 140.21 Yamamoto, Kazuko, Wiley, Mark, 190.15 190.56 Wu, Guoping, 124.4 Xiang, Zou, 196.5 51.14 Wilfahrt, Drew, 56.15 Wong Baeza, Carlos, Wu, Haiyan, 130.28 Xiao, Hanxi, 181.24 Yamamura, Asami, Wilking, James, 51.6 132.11 Wu, Hongyu, 190.16 Xiao, Hui, 56.4, 190.16 187.19, 190.43 Wilkinson, Daniel, Wong Ram´ırez, Carlos, Wu, Jianjun, 180.15 Xiao, Tsan, 63.9 Yamanouchi, Jun, 138.5, 186.15 132.11 Wu, Jianlin, 133.12 Xiao, Yangming, 65.15 132.17 Wilkinson, Robert, Wong, Ashley, 70.4 Wu, Juan, 178.2, 179.1 Xiao, Zhengguo, 56.8 Yamashiro, Shigeko, 190.78 Wong, Bernice, 122.3 Wu, Kevin, 194.29 Xie, Anyan, 68.13, 51.2 Willert, Erin, 70.21 Wong, Brian, 119.5 Wu, Lan, 60.6 182.10 Yamashita, Michifumi, Willey, James, 194.10 Wong, Chinn, 74.12 Wu, Lihong, 50.17 Xie, Chen, 187.13 67.1 Williams, Calvin, 192.21 Wong, Christina, 195.11 Wu, LongJun, 76.2 Xie, Hang, 139.20 Yamazaki, Takumi, Williams, Carmen, Wong, Eileen, 182.86 Wu, Ming-Shiang, Xie, Markus, 119.15, 194.24 51.14 Wong, Junmei, 182.54 117.12 121.1 Yamazaki, Yasuhiro, Williams, Grace, 61.19 Wong, Kwok-Kin, Wu, Qi, 115.1, 179.5, Xie, Ping, 58.9, 186.16 52.14 Williams, John, 198.2, 134.13 179.10 Xie, Wei, 58.5 Yan, Chi Wing, 195.13 198.10 Wong, Rachel, 121.13 Wu, Qian, 62.3, 190.66 Xie, Xuping, 197.13 Yan, Hao, 70.22, Williams, Linus, 69.31 Wong, Yik Chun, 195.13 Wu, Qiongwen, 120.17 Xie, Zhihui, 182.17 130.13 Williams, Matthew, Wong-Baeza, Isabel, Wu, Renee, 177.33 Xie, Zhonghui, 117.9 Yan, Hui, 121.11, 195.6 115.10, 136.1, 186.3 190.86 Wu, Shang-Gin, 131.24 Xie, Zhongping, 127.11 Yan, Jun, 135.14, Williams, R Michael, Woo, Jin Seok, 63.3 Wu, Shin-Rong, 56.6 Xin, Gang, 75.3 194.14 120.5, 182.79 Woo, Minkyu, 73.21 Wu, Shuai, 121.11, Xing, Changsheng, Yan, Min, 127.11 Williamson, Peter, Wood III, William, 65.14 195.6 51.1 Yan, Nan, 180.15 190.14 Wood, David, 190.10 Wu, Shu-Wei, 56.8 Xing, Xiaohui, 192.19 Yan, Xiaocai, 192.14 Wilmore, Joel, 188.3 Wood, Steven, 130.39 Wu, T.C., 70.11, 196.21 Xing, Yan, 190.25 Yan, Yan, 196.23 Wilson, David, 196.20 Woodfin, Anne, 50.11 Wu, Tianfu, 179.2 Xiong, Yong, 194.13 Yan, Yu-xin, 52.21, Wilson, Neco, 73.11 Woodman, Scott, 134.6 Wu, Ting-Ting, 62.8 Xu, Bin, 194.16 131.11 Wilson, Nicolette, 189.8 Woods, David, 194.21 Wu, Tuoqi, 140.2 Xu, Huanbin, 197.24 Yan, Zhaoqi, 52.3, Wilson, Patrick, 74.6 Woods, Jonathan, Wu, Wells, 64.7 Xu, Huaxi, 60.1, 135.11 188.1 Wilson, R. Paul, 129.5 67.24, 189.16 Wu, Wenzhe, 198.9 Xu, Jingda, 135.14 Yan, Zhen, 130.20 Wilson, Timothy, 126.29 Woodside, Steven, Wu, Xiang, 128.2 Xu, Jintao, 190.9, Yanamandra, Ananta, Winans, Thomas, 115.6 58.3, 71.3, 130.14, Wu, Xiaobo, 69.21 190.14 70.15 Winchell, Caylin, 190.3 130.18 Wu, Xiaojin, 69.24 Xu, Jiuyang, 198.10 Yandell, Mark, 120.31, Windsor, Jana, 182.55 Woolard, Matthew, Wu, Xiaorong, 68.3 Xu, Meizhen, 130.40 182.83 Winfield, Malika, 132.9 120.35 Wu, Yanhong, 194.25 Xu, Miaomiao, 60.10 Yang, Anne, 61.20 Wingard, Christopher, Workalemahu, Wu, Yaxu, 75.1 Xu, Rong, 189.17 Yang, Bi-Huei, 128.10, 187.20 Grefachew, 138.16 Wu, Yee Ling, 123.17 Xu, Tianhao, 189.5 178.16 Wingender, Gerhard, Workman, Gail, 180.11 Wu, Yen-Fei, 185.8 Xu, Xiao-ning, 71.20 Yang, Bingyu, 69.24 65.11 Worth, Randall, 194.10 Wu, Yexin, 57.21 Xu, Xiaoyan, 190.54, Yang, Bobae, 118.5 Winslow, Gary, 188.5, Worthington, Atesh, Wu, Yi, 59.18 191.5 Yang, Dafeng, 195.26 188.18 118.13 Wu, Yin, 64.17 Xu, Xiqiu, 194.13 Yang, Darong, 64.17 Winters, Aidan, 194.21 Wozniak, Daniel, 190.66 Wu, Yue, 129.18 Xu, Yichi, 63.15 Yang, De, 68.17 Wise-Draper, Trisha, Wright, Victoria, 182.61 Wunderlich, Thomas, Xu, Yinyan, 197.14 Yang, Eunjeong, 117.2 195.34 Wright, Jacqueline, 181.4 Xu, Yun, 62.10 Yang, Guo-Xiang, Witherden, Deborah, 179.13 Wustrow, David, 119.5 Xu, Zhenjian, 57.3 179.3 53.4, 60.12, 194.1 Wright, Nathan, 182.16 Wylie, Dennis, 193.5 Xu, Zhenming, 121.11, Yang, Huan, 133.17 Witt, Michelle, 59.13, Wright-McAfee, Erika, Wyman, Brandon, 115.6 195.6 Yang, Huang-Yu, 190.18 196.17 Wynne-Jones, Erica, Xu, Zhigang, 140.15 115.23 Witte, David, 181.9 Wroblewska, 66.14 Xue, Dan, 177.8 Yang, Hung-Chih, Witztum, Joseph, 59.2 Aleksandra, 138.19 Wysocki, Christian, Xue, Li, 130.36 196.15, S79 Wolchok, Jedd, 134.13, Wu, Beibei, 63.3 182.32 Yang, Hyungjun, 192.3 136.23, 137.3 Wu, Bing, 128.13 Yang, Jianbo, 56.4 Wolf, Gideon, 56.14 Wu, Bogang, 195.16, Y Yang, Jie, 63.9 Wolf, Jennifer, 74.10, 195.29 X Yadava, Koshika, Yang, Jihyun, 139.15 197.5 Wu, Chao-Yi, 115.23 Xi, Lihui, 195.11 119.14 Yang, Jing, 75.12, Wolf-Dennen, Kerri, Wu, Cheng-Jang, 134.3 Xia, Jingya, 198.5 Yagita, Hideo, 183.16 140.21 135.13 Wu, Chia-Chi, 54.16, Xia, Chuan, 74.10, Yakovenko, Olga, Yang, Jun-Qi, 181.20 Wolfgang, Michael, 122.15, 126.30 197.5 63.12 Yang, Kai, 53.5, 121.1 118.17 Wu, Chung-An, 123.22 Xia, Houjun, 137.11 Yalaka, Bharathi, 115.3, Yang, Lily, 71.2 Won, Dong-Hoon, Wu, Chung-Yi, S79 Xia, Junrong, 137.15 180.19 Yang, Liping, 75.6 196.25 Wu, Daniel, 182.24 Xia, Mei, 190.10 Yamabhai, Montarop, Yang, Meixiang, Won, Hye-ji, 57.22 Wu, Depei, 69.25 Xia, Xueqing, 135.14 140.15 180.14

170 AUTHOR/SPEAKER INDEX

Yang, Ning, 197.8 Yeshanew, Addisu, You, Zhiping, 130.36 Yukawa, Masashi, Zayats, Romaniya, Yang, PingAr, 115.1, 190.56 Younai, Ashkaan, 119.5 125.13 190.21 179.5, 179.10 Yetkin, Mehmet, 193.12 Younes, Ahmed, Yun, Cheol-Heui, Zbieg, Jason, 133.3 Yang, Se-Hwan, 189.15 Yeung, Bertrand, 131.4, 136.11 127.24, 189.4 Zebrowski, Elizabeth, Yang, Ting, 127.11 131.13 Young, Corey, 52.7, Yun, Jun-Won, 196.25 120.32 Yang, Tze-Pin, 135.19 Yeung, Frank, 131.3 52.8, 181.14, 181.17, Yunis, Edmond J., Zeiser, Robert, 69.10, Yang, Wei, 52.3, 188.1, Yeung, Stephen, 126.14 194.36 120.5, 182.79 69.38 190.25 Yewdell, Jonathan, Young, Katharine, Yushchenko, Dmytro, Zeldis, Jerome, 130.1 Yang, Wenjing, 191.15 56.19, 74.13, 139.20 138.3 130.27 Zellner, Matthew, 119.7 Yang, Xiaoming, 182.20 Yi, Ae-Kyung, 133.18 Young, Matthew, 140.5, Yussman, Martin, 68.9 Zemans, Rachel, 51.14 Yang, Xifeng, 52.20, Yi, Tangsheng, 132.4 140.15 Yuzefpolskiy, Zeng, Defu, 69.11 64.15, 128.20, 184.6, Yilmaz, Ozlem, 185.15 Young, Vincent, 190.69 Yevgeniy, 60.15, Zeng, FanLian, 52.10, 194.38 Yim, Aldrin, 64.1 Youngblood, Ben, 71.16, 181.24 182.74 Yang, Xinxiang, 195.13 Yin, Dengping, 69.12 134.14 Zeng, Weiguang, 74.12 Yang, Xuexian, 128.2 Yin, Bingnan, 51.1 Younger, John, 131.1 Zeng, Yan, 136.12 Yang, Yang, 132.17, Yin, Chibiao, 197.22 Youngheun, Jee, Z Zenke, Yukari, 116.10 188.11 Yin, Deling, 57.1 117.22, 119.10 Zafar, Jawad, 128.8 Zenkov, Viktor, 122.1, Yang, Yi, 116.10 Yin, Dengping, 69.20 Yu, Amy, 191.1 Zaghouani, Habib, 122.14 Yang, Yong-Guang, Yin, Jianhai, 190.83 Yu, Biaoyi, 186.5 181.1 Zeppa, Joseph, 139.3 182.18 Yin, Jiming, 194.16 Yu, Bingfei, 125.6, Zahner, Sonja, 67.8, Zeumer, Leilani, 132.12 Yang, Yu-Sang Yin, Sha, 186.5 138.6, 188.8 126.38 Zeumer-Spataro, Sabrina, 121.9 Yin, Zhengqin, 69.44 Yu, Cheng-Rong, Zaidi, Mohammad, 70.8 Leilani, 115.7 Yang, Zening, 120.17 Yin, Zhinan, 60.10, 123.10, 180.6 Zaiken, Michael, 69.42 Zewdie, Martha, 190.56 Yang, Zhiyong, 123.22 132.16 Yu, Guan, 180.10 Zaitseva, Marina, 64.7, Zhai, Lijie, 137.2 Yangming, Xiao, 65.16, Yip, Victor, 131.19 Yu, Hai, 70.14, 130.5 64.8 Zhang, Baihao, 56.2 115.25 Yirsaw, Alehegne, 73.23 Yu, Haisheng, 75.1 Zajac, Cynthia, 56.6 Zhang, Bin, 53.22, 58.5, Yao, Chen, 140.2 Yokanovich, Lila, 56.20 Yu, Hongbing, 192.3 Zak, Jaroslav, 121.4 70.12, 134.7 Yao, Jie, 182.39 Yokoyama, Jason, Yu, I-Chen, 165.1 Zakem, Jerald, 133.16 Zhang, Chengxin, 117.9 Yao, Suxia, 191.15 71.16 Yu, Jeanna, 177.18 Zakharov, Pavel, 116.5, Zhang, Chenyu, 135.9 Yao, Yi, 118.12 Yokoyama, Wayne M, Yu, Jessie, 71.3 180.4, 180.5 Zhang, Chi, 64.20 Yarmarkovich, Mark, 75.6, 177.23, S24 Yu, Jhang-Sian, 117.12 Zaki, Hasan, 187.34, Zhang, Deyi, 136.14, 130.4 Yokozeki, Hiroo, 55.10 Yu, Jiaming, 51.1 194.44 195.17 Yasui, Masato, 129.15 Yolcu, Esma, 69.1 Yu, Jiyeon, 126.22 Zaman, Mohammad, Zhang, Faya, 65.12 Yasutomi, Yasuhiro, Yolcu, Esma S., 71.6 Yu, Kevin, 129.1 180.4 Zhang, Fei, 70.22 74.15, 139.4 Yong-Woo, Kim, 51.19 Yu, Lan, 183.6 Zamarin, Dmitriy, 137.3 Zhang, Fuchun, 197.22 Yates, Kathleen, 58.17 Yoo, Sae-Mi, 182.9 Yu, Lei, 197.22 Zamboni, Dario, 190.42 Zhang, Guang-Xian, Yau, Jessica, 134.8 Yoo, Bora, 116.17 Yu, Miao, 50.17 Zambuzi, Fabiana, 50.18 Yau, Simon, 133.7 Yoo, Sungyoung, Yu, Qigui, 75.12 125.10 Zhang, Guizhong, Yaun, Ce, 194.15 181.22 Yu, Qing, 116.17 Zan, Hong, 121.11, 194.18 Ye, Cheng, 50.9 Yoon, Hee Jung, 126.15 Yu, Quigui, 140.21 123.14, 182.78 Zhang, Haiju, 57.1 Ye, Jung-Hsuan, 138.8 Yoon, Jeesang, 128.9 Yu, Xiaoqing, 135.25, Zanetti, Maurizio, Zhang, Haohai, 182.10 Ye, Peifang, 130.17, Yoon, Sung Sik, 117.8 138.4 135.29 Zhang, Hong, 194.38 134.16, 194.33 Yoon, Taewon, 133.18 Yu, Xu, 120.3 Zang, Aiping, 56.4 Zhang, Hongji, 135.2 Ye, Richard, 187.4 Yopes, Margot, 67.21 Yu, Xue-Zhong, 57.12 Zang, Xingxing, 69.10, Zhang, Hongjuan, Ye, Siying, 130.19 Yorek, Matthew, 127.3 Yu, Yeon-sil, 182.9 185.9, 190.82 137.11 Yeager, Michael, 52.1 Yosef, Nir, 124.14 Yu, Yueh-Hsiang, Zang, Yunjin, 194.16 Zhang, Hongwei, Yeasmin, Shaila, 67.13 Yoshida, Maiko, 130.32 139.21 Zangari, Paola, 72.11 117.23, 183.21 Yeckes, Alyson, 186.12 Yoshida, Tomomi, Yu, Zhihong, 55.15, Zanotti, Brian, 133.13 Zhang, Huajia, 135.3 Yee, Cassian, 189.10 138.6 119.26 Zapardiel-Gonzalo, Zhang, Huan, 69.44 Yellin, Michael, 70.9, Yoshimoto, Keiko, Yu, Zouzou, 136.12 Jose, 131.18, 182.27 Zhang, Huang-Ge, 136.4 132.1, 182.23 Yuan, Fang, 178.18 Zarei, Kasra, 178.13, 192.4 Yen, Hung-Rong, Yoshimura, Masami, Yuan, Jinzhou, 60.5 178.14 Zhang, Hui, 134.10 133.14, 193.6 187.14 Yuan, Wuxing, 191.6 Zarin, Isma, 66.8 Zhang, Huiyuan, Yen, Jui-Hung, 165.1 Yoshimura, Satoshi, Yuan, Ye, 132.12 Zarlenga, Dante, 127.16 124.14, 137.15 Yeo, Gene, 125.20 50.18 Yuan, Yulin, 179.2 Zarling, Stasya, 190.48 Zhang, Jian, 115.13, Yeoh, Beng San, 59.3, Yoshiyama, Takashi, Yuan, Zhou, 194.5 Zarnitsyna, Veronika, 181.15 192.9 177.10 Yue, Lei, 127.11 76.14 Zhang, Jibin, 73.8, Yerden, Randy, 131.14 You, Dahui, 124.5, Yue, Xiaojing, 123.15 Zarozinski, Christopher, 177.6 Yerneni, 198.11 Yuen, Kit-San, 127.4, 52.21 Zhang, Jing, 124.1 Saigopalakrishna, You, Gihoon, 121.3 127.6 Zawieja, David, 54.10 Zhang, Jingbo, 132.13 69.1 You, Ran, 194.23 Yuhoi, Jessica, 61.19 Zawislak, Carolyn, 76.9 Zhang, Juan, 133.3

171 AUTHOR/SPEAKER INDEX

Zhang, Kai, 185.7 Zhang, Yichuan, 68.15 Zheng, Huiwen, 120.17 Zhou, Wei, 181.20 Zhuang, Xiufen, 194.25 Zhang, Li, 75.13 Zhang, Yongxi, 194.13 Zheng, Jian, 140.13, Zhou, Xiaofei, 62.4 Zhuang, Yuxin, 133.12 Zhang, Linda, 53.19 Zhang, Youjie, 182.6 183.7, 198.4 Zhou, Xiaoying, 119.1 Zicari, Sonia, 72.11 Zhang, Long, S106 Zhang, Yu, 52.14, Zheng, Jiaying, 76.2 Zhou, Xikun, 127.1 Ziegelbauer, Jennifer, Zhang, Lu, 64.12 123.18, 198.10 Zheng, Mingzhu, Zhou, Xing, 179.3 192.21 Zhang, Minghui, 195.21 Zhang, Yuxia, 186.10 124.13, 188.10 Zhou, Yu, 133.2 Ziegenfuss, Marc, Zhang, Nu, 183.2 Zhang, Zemin, S106 Zheng, Song, 57.3, Zhou, Zhanxiang, 182.69 Zhang, Peisheng, 138.1 Zhao, Amy, 130.24, 116.1, 133.1, 133.8 182.33 Ziegler, Steven, 195.32 Zhang, Penglie, 133.7 130.25, 194.40 Zheng, Xiaoqun, 75.12 Zhu, Baogong, 195.31 Zielinska-Kwiatkowska, Zhang, Ping, 69.38 Zhao, Haiyan, 121.13 Zheng, Xiufen, 59.17 Zhu, Bibo, 60.2, 74.5, Anna, 189.16 Zhang, Qiang, 188.2 Zhao, Hong, 71.6 Zheng, Ye, 128.1 129.18, 135.28 Zimmerman, Daniel, Zhang, Qiong, 185.1 Zhao, Jianjun, 188.12 Zheng, Yi, 181.20 Zhu, Cheng, 194.5 133.4 Zhang, Ray, 183.13 Zhao, Keiji, 186.3 Zheng, Zhichao, 50.17 Zhu, Chengsong, 69.30 Zinselmeyer, Bernd, Zhang, Rong, 64.22 Zhao, Kelei, 127.1 Zheng, Zhong, 53.19 Zhu, Cuilin, 59.17 133.5, 180.5 Zhang, Ruixuan, 129.18 Zhao, Lili, 191.1 Zhong, Hong, 134.13 Zhu, JiaLou, 122.6 Ziraldo, Solongo, Zhang, Sai, 57.10 Zhao, Lu, 133.10 Zhong, Jixin, 182.29 Zhu, Jiang, 197.22 194.29 Zhang, Sara, 131.36 Zhao, Qin, 130.28 Zhong, Wei, 182.33 Zhu, Jie, 71.19 Zloza, Andrew, 136.6, Zhang, Shengnan, Zhao, Qing, 191.7 Zhong, Yajie, 116.6 Zhu, Jinfang (Jeff), 177.17 185.11 Zhao, Qingnan, 135.14 Zhong, Zhenyu, 125.1 124.13, 128.12, Zoccoli-Rodriguez, Zhang, Tianzhuo, 186.5 Zhao, Tuantuan, 182.44 Zhou, Angela, 140.7 130.12, 188.10, S142 Victoria, 132.7 Zhang, Weici, 179.3 Zhao, Wenming, 74.14 Zhou, Bing, 125.20 Zhu, Jing, 116.12 Zong, Xinying, 131.34 Zhang, Wenliang, 198.5 Zhao, Xianda, 194.15 Zhou, Gang, 194.8 Zhu, Jingru, 69.41 Zou, Jia, 51.1 Zhang, Wensheng, Zhao, Xiang, 189.6 Zhou, Gengming, Zhu, Lei, 177.27 Zou, Song, 117.9 69.46 Zhao, Xin, 64.22 182.73 Zhu, Li, 74.14 Zou, Weiping, 137.11 Zhang, Xian, 181.3 Zhao, Xinbin, 58.5 Zhou, Hong, 52.10, Zhu, Min, 182.25 Zsiros, Emese, 137.13 Zhang, Xiang, 178.18 Zhao, Xinfang, 131.4, 59.1, 182.74, 185.11 Zhu, Shang, 50.17 Zullo, Kelly, 192.8 Zhang, Xiaorong, 50.17 131.13 Zhou, Jiajia, 137.11 Zhu, Sining, 58.9 Zuluaga-Ramirez, Zhang, Xin, 133.16 Zhao, Yanding, 138.1 Zhou, Jie, 128.20, Zhu, Wenjie, 190.54, Viviana, 132.9 Zhang, Xin-Tian, Zhao, Yangzhi, 124.12 137.4, S106 191.5 Zuniga, Elina, 185.7, 190.12, 190.83 Zhao, Yang-Zhi, 138.18 Zhou, Jing, 116.17 Zhu, Xiaodong, 135.3 187.28 Zhang, Xinwei, 53.7 Zhao, Yanxia, 188.14 Zhou, Julie, 56.7 Zhu, Yanfang, 182.1 Zuniga, Joaquin, 120.5, Zhang, Xinyue, 75.17, Zhen, Yuxuan, 59.8 Zhou, Li, 118.12, 133.8, Zhu, Yangyang, 188.14 182.79 136.3, 136.15, 195.29 Zheng, Grace, 194.29 194.13 Zhu, Ying, 69.7 Zurita, Jeffrey, 123.18 Zhang, Xinyun, 66.1 Zheng, Guoxing, Zhou, Lining, 135.11 Zhu, Zhaohui, 134.10 Zwezdaryk, Kevin, Zhang, Xiuyue, 127.1 196.30 Zhou, Qin, 128.2 Zhu, Ziang, 120.24 125.16 Zhang, Xue, 69.28 Zheng, Handong, 128.2 Zhou, Runhong, 75.22 Zhuang, Ke, 194.13 Zwick, Danny, 69.29 Zhang, Xuhua, 60.18 Zheng, Huaping, 52.10, Zhou, Shuntai, 197.14 Zhuang, Xiaoxuan, Zygmunt, Marek, Zhang, Yan, 131.33 59.1, 117.9, 182.74 Zhou, Tong, 182.18 134.5 123.19

172 NOTES NOTES