Guy BERTRAND Professional Address Education Research
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UC San Diego Electronic Theses and Dissertations
UC San Diego UC San Diego Electronic Theses and Dissertations Title Development and Reactivity Studies of Highly Ambiphilic Carbenes Permalink https://escholarship.org/uc/item/57t561ss Author Weinstein, Cory Publication Date 2018 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA, SAN DIEGO Development and Reactivity Studies of Highly Ambiphilic Carbenes A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Chemistry by Cory Michael Weinstein Committee in charge: Guy Bertrand, Chair Michael K. Gilson Joseph M. O’Connor Arnold L. Rheingold Haim Weizman 2018 Copyright Cory Michael Weinstein, 2018 All rights reserved The dissertation of Cory Michael Weinstein is approved, and it is acceptable in quality and form for publication on microfilm and electronically: Chair University of California, San Diego 2018 iii DEDICATION This dissertation is dedicated to my mom Without her endless sacrifices and unconditional love and support Nothing I have ever done would have been possible iv EPIGRAPH “luck is always better than skill at things” -James Murphy but “chance favors the prepared mind” -Louis Pasteur v TABLE OF CONTENTS Signature Page ............................................................................................................................................. iii Dedication ................................................................................................................................................... -
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..f.,5$1______ -~ survey -------) WHO WAS WHO IN KINETICS, REACTION ENGINEERING, AND CATALYSIS CAMI L. JACKSON AND JOSEPH H . HOLLES University of liyoming • Laramie, WY 82071 n the tradition of "Who was Who in Transport Phenom We have tried to include the names that are encountered ena" by Byron Bird in Chemical Engineering Education,CI J frequently in textbooks for both undergraduates and gradu Iwe have developed a similar set of microbiographies for ates (by noted authors such as Levenspiel, Hill, Fogler, and persons in the fields of kinetics, reaction engineering, and Froment and Bischoff). Again, we follow Bird's lead and do catalysis. As noted by Bird, an otherwise typical lecture not include these people simply for authoring books in these can be enlivened by presenting biographical information fields . We do, however, include-where appropriate- famous about the people whose names appear in famous equations, texts written by those scientists and engineers included for dimensionless groups, plots, approximations, and theories . other reasons. We have tried to focus on those persons who The wide variety of applications for this type of information contributed to the science of a field and not just contributed to has been demonstrated by using activity breaks to teach the a specific reaction or system (e.g., Haber and Bosch). While history of our professionl21 and as trading card rewards for contributions to specific reactions or systems are important, academic performance _l31 we elected not to include them in order to limit the scope of With the introduction and widespread acceptance ofWiki the project. Finally, we have tried to include interesting non pedia, basic biographical information on many of the early technical or non-professional information where possible to contributors to the profession of chemical engineering can be show the breadth of these individuals. -
PRATO, Maurizio
Prof. Maurizio Prato Professor of Organic Chemistry, Dipartimento di Scienze Chimiche e Farmaceutiche University of Trieste, Italy and Ikerbasque Professor, CIC BiomaGUNE, San Sebastián, Spain Maurizio Prato graduated in Padova, Italy, where he was appointed Assistant Professor in 1983. He moved to Trieste in 1992, to become Full Professor in 2000. Since the end of 2015, he has been appointed Research Professor at CIC BiomaGUNE in San Sebastián, Spain. His research focuses on the application of all aspects of organic chemistry, synthetic and mechanistic, to build functional materials finalized to solve relevant problems in biology, medicine, and solar energy conversion. He was the recipient of an ERC Advanced Research Grant, European Research Council, 2008 and has become a Member of the National Academy of Sciences (Accademia Nazionale dei Lincei) in 2010. Has published more than 500 papers on international peer reviewed Journals, with a total of around 40,000 citations and an h-index of 105 (google scholar) or 95 (web of science). Has been invited to more than 200 conferences and workshops in the last 10 years as a plenary or keynote speaker, and has given more than 50 invited talks in Universities or research centers all around the world. PROFESSIONAL CAREER 1978 Laurea degree, University of Padova, Department of Organic Chemistry 1983-92 Assistant professor in Organic Chemistry, University of Padova 1986-1987 Postdoctoral fellow: Yale University, New Haven, USA, Chemistry Department 1991-1992 Visiting scientist, University of California, -
YEARBOOK Medicinal Chemistry in Europe
EFMC YEARBOOK Medicinal Chemistry in Europe EFMC-ISMC 2020 EFMC-YMCS 2020 EFMC-ASMC’19 Basel, Switzerland Basel, Switzerland EFMC-YMCS 2019 September 6-10, 2020 September 10-11, 2020 Special reports EFMC International Symposium on Medicinal Chemistry Basel, CH September 6-10, 2020 SESSIONS AND SESSION COORDINATORS EFMC AWARD LECTURES CHEMICAL BIOLOGY THERAPEUTIC AREAS – The Nauta Pharmacochemistry Award – The UCB-Ehrlich Award for Excellence in Medicinal CARBOHYDRATE RECOGNITION AND DRUG DESIGN ADDRESSING NEGLECTED AND EMERGING VIRAL Chemistry Alexander Titz (Helmholtz Institute for Pharmaceutical DISEASES WITH SMALL MOLECULES AFMC Session – The Prous Institute-Overton and Meyer Award for New Sciences, DE) Esin Aki-Yalçin (Ankara University, TR) Technologies in Drug Discovery CHEMICAL APPROACHES TO STEM CELL BREATHING LIFE INTO INHALED DRUG DISCOVERY: DIFFERENTIATION ICBS Session CHALLENGES AND BREAKTHROUGHS TO THE CLINIC EFMC PARTNER PRIZES Colin Pouton (Monash University, AU) ACSMEDI Session Nicole Goodwin(GSK, US) – The IUPAC-Richter Prize in Medicinal Chemistry CHEMICAL PROBES FOR TARGET DISCOVERY AND – The Klaus Grohe Prize VALIDATION CHEMICAL TOOLS AND DRUG DISCOVERY FOR Gyorgy Keseru (Hungarian Academy of Sciences, HU) NEUROINFLAMMATION EUCHEMS Session EFMC PRIZE LECTURES Sonsoles Martin-Santamaria (Biological Research Center, ES) MOLECULAR IMAGING TOOLS FOR CHEMICAL BIOLOGY Valle Palomo (CIB, ES) NEW STRATEGIES AND AGENTS FOR TARGETING – EFMC Prize for a Young Medicinal Chemist in Industry GRAMNEGATIVE PATHOGENS – EFMC Prize -
Curriculum Vitae
Curriculum Vitae Cinzia Chiappe received Laurea (cum laude) and PhD degrees from the University of Pisa, Italy, in 1985 and 1989, respectively. After a two years period at the Regional Agency for Environmental Protection, she moved to the Department of Bioorganic Chemistry (University of Pisa) as a researcher. Since 2002 she is Full Professor of Organic Chemistry at the University of Pisa. Her primary research interests focus on the ionic liquids (ILs) chemistry and their application. Using the tools of physico- organic chemistry her research group is dedicated to obtain information on ILs and their physico-chemical and biological properties, often correlating experimental results with theoretical calculations. In this field, she has developed several projects that using these “designer solvents” as novel media and catalysts have allowed to develop new and more sustainable chemical processes affording a lot of new compounds and materials. Goal of her research work is indeed to develop new classes of optimized ILs to apply as solvents and/or catalysts in real-world problems: in other words to provide more effective chemical reactions or to develop novel platforms for more efficient extractions, separations and, in general, energy-saving processes. She has been several times principal investigator for research programs funded by Consiglio Nazionale delle Ricerche (CNR), MIUR (Prin 2003), Fundations (CaRiPi “Sviluppo di Nuovi Liquidi Ionici da Utilizzare come Additivi nell’Industria delle Vernici” 2008-2009, CaRiPi “Nuovi sistemi polimerici con funzionalità elettriche ed ottiche ottenuti per micro e nano-dispersione adesiva e loro impiego come materiali e dispositivi per applicazioni intelligenti” 2011-2014), Regione Toscana (Innovazione ed ecocompatibilità nella tintura di tessuti in poliestere e bambù, 2008) and European Community (Iolisurf, 2007-2011; SWAN-Icare 2012-2016). -
Year Book - 2020
YEAR BOOK - 2020 2020 YEAR BOOK 01 YEAR BOOK - 2020 YEAR BOOK - 2020 ACKNOWLEDGEMENT THE EDITORS The Editorial Team is very thankful to all who helped Nineta Hrastelj (Editor-in-Chief), creating and shaping the 2020 Yearbook, in particular Jelena Lazić (Managing Editor), to Pilar Goya, EuChems President (2018-2020). Laura Jousset Every effort has been made in preparing this publi- cation. Nevertheless, the authors, the editors, and the publisher disclaim the liability for the accuracy of information, references, recommendations, and for any printing errors. PUBLISHER & COPYRIGHT All rights reserved (including those of translating into other languages). No part of this publication European Chemical Society (EuChemS) aisbl may be reproduced in any form – by photo prin- Rue du Trône 62 ting, microfilming, or by any other means – nor 1050 Brussels, Belgium transmitted or translated into a machine language +32 2 289 25 67 without written permission of the publisher. www.euchems.eu [email protected] © EuChemS aisbl Transparency Register: 03492856440-03 @EuChemS ISBN (PDF online) 978-2-9601655-7-9 ISBN (printed version) 978-2-9601655-8-6 CONTENT © design by Mathilde Glocheux, Aupluriel Editorial 4 General Assembly 6 Executive Board 8 Policy Initiatives 10 Fostering European Chemistry 16 Science Communication 24 Awards 26 Events 30 Professional Networks 36 Member Societies and Supporting Members 56 02 03 YEAR BOOK - 2020 YEAR BOOK - 2020 take place at the University of Chemistry and With the aim of further extending our collabora- Technology, in Prague, on the 3rd July where it tion with other organisations, we have recent- all started 50 years ago. -
N E W S L E T T E R Euchems Future Strategy
EuCheMSEuCheMSSeptember 2009 NEWSLETTER EuCheMS future strategy New EYCN steering group Having served nearly one year as Presi- The annual European Young Chemistry Net- dent, it is clear to me that EuCheMS has work (EYCN) Delegate Assembly took place on come a long way as a European Association 10 to 11 March 2009 during this year’s through developing its strong science base Frühjahrsymposium in Essen, Germany. With and pursuing effective EU policy activity. the Swedish Chemical Society as a new mem- However, organisations need to look to the ber EYCN now consists of 21 member societies future and EuCheMS is no exception. and one affiliated member society. In addi- Now increasingly seen as an essential tion, the Delegate Assembly elected a new partner in European science initiatives, steering committee for the next two years. EuCheMS is also taking a more strategic ap- Nevertheless, the new steering committee proach to encouraging professional devel- EuCheMS President Luis Oro. has a challenging task ahead, as the first opment and networking, enhancing com- steering committee was largely responsible munication and recognition and improving • enhance recognition of EuCheMS by for the creation of EYCN. its decision-making structures. As agreed by member societies and their individual Taking into account previous experience, the Executive Committee in April, seven members (Chair: Franco De Angelis, some amendments were made to the EYCN Task Groups are helping to Italian Chemical Society), rules concerning posts in the steering group. A • establish and implement a sustainable • explore the feasibility of establishing a new position of an advisor was added to the policy development activity EuCheMS academy of chemistry steering committee, which will be occupied (Chair: Rodney Townsend, Royal Society (Chair: Jay Siegel, Swiss Chemical Society), by the former chair Csaba Janáky. -
Annual Meeting – Minutes 2011
Division of Analytical Chemistry European Association for Chemical and Molecular Sciences 2011 Annual Meeting 42 nd Meeting of EuCheMS-DAC Sunday, September 11, 2011 Time: 9.00 am. - 2.00 pm. Venue: Belgrade, Congress Center Sava, Room 9, Ground floor Minutes of the Meeting Participants Austria Prof. W. Buchberger * Austrian Society of Analytical Chemistry Brazil Prof. S. Cadore Brazilian Chemical Society Cyprus Dr. C. P. Kapnissi - Christodoulou * Pancyprian Union of Chemists Czech Rep. Prof. J. Barek* Czech Chemical Society Denmark Dr. J. Andersen* Danish Chemical Society France Dr. C. Rolando* Societé Chimique de France Germany Prof. R. Salzer* Gesellschaft Deutscher Chemiker Dr. E.-H. Korte Deutsche Bunsen-Gesellschaft für Physikalische Chemie Greece Prof. M. Karayannis * Association of Greek Chemi sts Hungary Prof. G. Horvai* Hungarian Chemical Society Division of Analytical Chemistry European Association for Chemical and Molecular Sciences Israel Prof. D. Mandler The Israel Chemical Society Italy Prof. L. Sabbatini* Italian Chemical Society Poland Prof. M. Jarosz* Polish Chemical Society Romania Dr. A-J. Stoica* Romanian Chemical Society Prof. R.-I. v an Staden Romanian Chemical Society Russia Prof. B. Ya. Spivakov * Russian Academy of Sciences Prof. S.N. Shtykov Medeleev Russian Chemical Society Serbia Prof. S. Ražić* Serbian Chemical Society Prof. I. Popovi ć Serbian Chemical Society Slovakia Prof. J. Labuda* Slovak Chemical Society South Africa Prof. K. van Staden South African Chemical Society Spain Prof. R. Tauler Catalan Chemistry Society Sweden Prof. B. Karlberg* Swedish Chemical Society U.K. Prof P . Worsfold* Royal Society of Chemistry Prof. D.T. Burns Royal Society of Chemistry 25 participants representing 20 countries. -
Article Mesoionic Carbene-Breslow Intermediates As Super Electron Donors: Application to the Metal-Free Arylacylation of Alkenes
ll Article Mesoionic carbene-Breslow intermediates as super electron donors: Application to the metal-free arylacylation of alkenes Wei Liu, Adam Vianna, Zengyu Zhang, ..., Mohand Melaimi, Guy Bertrand, Xiaoyu Yan [email protected] (G.B.) [email protected] (X.Y.) Highlights Breslow intermediates derived from mesoionic carbenes are super electron donors A mesoionic-carbene-catalyzed arylacylation of alkenes is described Facile construction of complex carbonyl compounds from simple substrates Breslow intermediates derived from mesoionic carbenes (BIMICs) are highly reductive species able to reduce iodoarenes under ambient condition. The reductive power of BIMICs allows for the use of mesoionic carbenes as powerful catalysts in the inter- and intramolecular arylacylation of alkenes. Liu et al., Chem Catalysis 1,1–11 June 17, 2021 ª 2021 Elsevier Inc. https://doi.org/10.1016/j.checat.2021.03.004 Please cite this article in press as: Liu et al., Mesoionic carbene-Breslow intermediates as super electron donors: Application to the metal-free arylacylation of alkenes, Chem Catalysis (2021), https://doi.org/10.1016/j.checat.2021.03.004 ll Article Mesoionic carbene-Breslow intermediates as super electron donors: Application to the metal-free arylacylation of alkenes Wei Liu,1 Adam Vianna,2 Zengyu Zhang,1 Shiqing Huang,1 Linwei Huang,1 Mohand Melaimi,2 Guy Bertrand,2,3,* and Xiaoyu Yan1,* SUMMARY The bigger picture Classical N-heterocyclic carbenes (NHCs), such as thiazolylidenes, N-Heterocyclic carbenes (NHCs) 1,2,4-triazolylidenes, and imidazol(in)-2-ylidenes, are powerful or- have been demonstrated to be ganocatalysts for aldehyde transformations through the so-called powerful organocatalysts for Breslow intermediates (BIs). -
Articles – Part 1: Principle of Measurements and Instrument Evaluation
Atmos. Meas. Tech., 9, 1721–1742, 2016 www.atmos-meas-tech.net/9/1721/2016/ doi:10.5194/amt-9-1721-2016 © Author(s) 2016. CC Attribution 3.0 License. LOAC: a small aerosol optical counter/sizer for ground-based and balloon measurements of the size distribution and nature of atmospheric particles – Part 1: Principle of measurements and instrument evaluation Jean-Baptiste Renard1, François Dulac2, Gwenaël Berthet1, Thibaut Lurton1, Damien Vignelles1, Fabrice Jégou1, Thierry Tonnelier3, Matthieu Jeannot1,4, Benoit Couté1, Rony Akiki3, Nicolas Verdier5, Marc Mallet6, François Gensdarmes7, Patrick Charpentier8, Samuel Mesmin8, Vincent Duverger1, Jean-Charles Dupont9, Thierry Elias10, Vincent Crenn2, Jean Sciare2, Paul Zieger11, Matthew Salter11, Tjarda Roberts1, Jérôme Giacomoni4, Matthieu Gobbi4, Eric Hamonou2, Haraldur Olafsson12, Pavla Dagsson-Waldhauserova12,13, Claude Camy-Peyret14, Christophe Mazel15, Thierry Décamps15, Martin Piringer16, Jérémy Surcin1, and Daniel Daugeron17 1LPC2E-CNRS, Université d’Orléans, 3A Avenue de la Recherche Scientifique, 45071 Orléans, France 2LSCE-CEA, Institut Pierre Simon Laplace, CEA Saclay 701, 91191 Gif-sur-Yvette, France 3Environnement-SA, 111 Boulevard Robespierre, BP 4513, 78304, Poissy, France 4Groupe Aerophile, 106 Avenue Felix Faure, 75015 Paris, France 5Centre National d’Etudes Spatiales (CNES), DCT/BL/NB, 18 Avenue Edouard Belin, 31401 Toulouse CEDEX 9, France 6Laboratoire d’Aérologie, Université Paul Sabatier, 14 Avenue Edouard Belin, 31400 Toulouse, France 7Institut de Radioprotection et de -
THE WORLD's Most Influential Scientific Minds 2014
ONY GENTILE T S/ R REUTE THE WORLD’S MOST INFLUENTIAL SCIENTIFIC MINDS 2014 “ Research is to see what everybody else has seen, and to think what nobody else has thought.” — Albert Szent-Gyorgyi (1893 – 1986) Physiologist and Nobel Prize recipient Cover Image: The sun is viewed through a telescope at the Vatican Observatory in Castelgandolfo, south of Rome, June 23, 2005. In the sleepy lakeside village of Castelgandolfo, away from the noise and haste of Rome, the Vatican is helping to train tomorrow’s astronomers, regardless of their religious beliefs. For the past 20 years, the Vatican Observatory, one of the world’s oldest astronomical institutes, has selected young, promising scholars for courses at the papal summer palace. INtrodUCTION Who are some of the best and brightest scientific minds of our time? Thomson Reuters answers this question, as it has The second section of researchers lists some in the past, by analyzing data using its Web of 3,200 individuals who published the greatest Science and InCites platforms to determine which number of highly cited papers in one of 21 broad researchers have produced work that is most fields, 2002-2012. Highly cited papers rank in frequently acknowledged by peers. the top 1% by citations for their field and year of publication. Both hot papers and highly cited These highly cited researchers were determined papers are featured in the Essential Science by analyzing at citation data over the last 11 years Indicators database of Thomson Reuters. to identify those who published the highest- impact work (2002—2012 and 2012—2013). -
Organometallic Chemistry and Applications
Chemistry 462 Fall 2017 MYD Organometallic Chemistry and Applications Note: Organometallic Compounds and Complexes Contain a M-C Bond. Organometallic chemistry timeline 1760 Louis Claude Cadet de Gassicourt investigates inks based on cobalt salts and isolates Cacodyl from cobalt mineral containing arsenic 1827 William Christopher Zeise produces Zeise's salt; the first platinum / olefin complex 1848 Edward Frankland discovers diethylzinc 1863 Charles Friedel and James Crafts prepare organochlorosilanes 1890 Ludwig Mond discovers nickel carbonyl 1899 Introduction of Grignard reaction 1899 John Ulric Nef discovers alkylation using sodium acetylides. 1900 Paul Sabatier works on hydrogenation of organic compounds with metal catalysts. Hydrogenation of fats kicks off advances in food industry; see margarine! 1909 Paul Ehrlich introduces Salvarsan for the treatment of syphilis, an early arsenic based organometallic compound 1912 Nobel Prize Victor Grignard and Paul Sabatier 1930 Henry Gilman works on lithium cuprates, see Gilman reagent 1951 Walter Hieber was awarded the Alfred Stock prize for his work with metal carbonyl chemistry—(but not the Nobel Prize). 1951 Ferrocene is discovered 1963 Nobel prize for Karl Ziegler and Giulio Natta on Ziegler-Natta catalyst: Polymerization of olefins 1965 Discovery of cyclobutadieneiron tricarbonyl 1968 Heck reaction 1973 Nobel prize Geoffrey Wilkinson and Ernst Otto Fischer on sandwich compounds 1981 Nobel prize Roald Hoffmann and Kenichi Fukui for expression of the Woodward-Hoffman Rules 2001 Nobel prize W. S. Knowles, R. Noyori and Karl Barry Sharpless for asymmetric hydrogenation 2005 Nobel prize Yves Chauvin, Robert Grubbs, and Richard Schrock on metal-catalyzed alkene metathesis 2010 Nobel prize Richard F. Heck, Ei-ichi Negishi, Akira Suzuki for palladium catalyzed cross coupling reactions The following slides are meant merely as examples of the catalytic processes we will explore later this semester.