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Billings Alexandra TTransgenderransgender aandnd HHIVIV Positively Aware HIV Treatment and Health Alexandra on Hollywood,Billings HIV, and her Chicago roots HormoneHHormorm Therapy and DrugD Interactions Profiles and Personal Stories July / August 2008 HAART 2.0 The Journal of Test Positive Aware Networkk INDICATION never taken HIV medications before or in Cafergot®, Ergomar®), methylergonovine, pediatric patients. cisapride (Propulsid®), pimozide (Orap®), PREZISTA (darunavir) is a prescription medication. ® ® PREZISTA does not cure HIV infection or AIDS, midazolam (Versed ), triazolam (Halcion ), It is one treatment option in the class of HIV ® ® ® and does not prevent passing HIV to others. rifampin (Rifadin , Rifater , Rifamate ), (human immunodeficiency virus) medicines ® Please read Important Safety Information lopinavir/ritonavir (Kaletra ), saquinavir known as protease inhibitors (PIs). ® ® below, and talk to your healthcare professional (Invirase ), lovastatin (Mevacor ), pravastatin PREZISTA is always used with 100 mg ritonavir ® ® to learn more about PREZISTA. (Pravachol ), simvastatin (Zocor ), (Norvir®) in combination with other HIV medicines carbamazepine (Tegretol®, Carbatrol®), for the treatment of HIV infection in treatment- IMPORTANT SAFETY INFORMATION phenobarbital, phenytoin (Dilantin®, Phenytek®), experienced adult patients, such as those with • Do not take PREZISTA if you are allergic or products containing St. John’s wort HIV resistant to more than one PI. to PREZISTA or any of its ingredients, or • Before taking PREZISTA, tell your doctor if • The use of other medications active against ritonavir (Norvir®) you are taking sildenafil (Viagra®), vardenafil your HIV in combination with PREZISTA/ritonavir ® ® • Please refer to the ritonavir (Norvir®) Product (Levitra ), tadalafil (Cialis ), atorvastatin (Norvir®) may increase the likelihood of your ® ® Information (PI and PPI) for additional (Lipitor ), atorvastatin/amlodipine (Caduet ), overall treatment response. Your healthcare ® information on precautionary measures or rosuvastatin (Crestor ). This is not a professional will work with you to find the right complete list of medicines. Be sure to tell combination of other HIV meds • Taking PREZISTA with certain medicines your doctor about all the medicines you are could cause serious and/or life-threatening • The long-term benefits and side effects of taking or plan to take, including prescription side effects or may result in loss of its PREZISTA therapy are unknown at this time. and nonprescription medicines, vitamins, effectiveness. Do not take PREZISTA if It is important that you remain under the care and herbal supplements you are taking the following medicines: of your healthcare professional astemizole (Hismanal®), terfenadine (Seldane®), • Tell your healthcare professional if you are PREZISTA is not approved for the treatment dihydroergotamine (D.H.E.45®, Migranal®), taking estrogen-based contraceptives. PREZISTA of HIV infection in adult patients who have ergonovine, ergotamine (Wigraine®, Ergostat®, might reduce the effectiveness of estrogen- in myself in my doctor Belief { in my care NPCXGQR?*glamk`gl_rgmlugrfLmptgp¥&pgrml_tgp'_lbmrfcpFGTkcbq*k_wfcjn jmucptgp_jjm_b_lbp_gqcrfclsk`cpmdRacjjq, Af\ana\mYdj]kmdlkoal`HJ=RAKL9 lj]Yle]fleYqnYjq&L`]]^^][lg^ HJ=RAKL9l`]jYhqgfnajYddgY\Yf\ L%[]dd[gmfl`YkZ]]f]nYdmYl]\af *klm\a]kl`YldYkl]\*,o]]ck& L`]dgf_%l]jeZ]f]ÕlkYf\ka\] ]^^][lkg^HJ=RAKL9l`]jYhqYj] mfcfgofYll`aklae] Ask your healthcare professional if PREZISTA is right for you. Hd]Yk]nakaluuu,NPCXGQR?,amk based contraceptives. You must take additional Your healthcare professional should perform • The most common side effects include diarrhea, precautions for birth control, such as a condom blood tests prior to and during your treatment nausea, headache, and common cold. If you • Before taking PREZISTA, tell your healthcare with PREZISTA experience these or other symptoms, talk to professional if you have any medical conditions, • Skin rashes ranging from mild to severe or your healthcare professional. Do not stop taking including allergy to sulfa medicines, diabetes, life-threatening have been reported in some PREZISTA or any other medications without first liver problems (including hepatitis B or C) patients receiving a PREZISTA-ritonavir talking to your healthcare professional or hemophilia regimen. Contact your healthcare professional PREZISTA should always be taken twice a day • Tell your healthcare professional if you are if you develop a rash with and at the same time as 100 mg ritonavir ® pregnant or planning to become pregnant, • High blood sugar, diabetes or worsening of (Norvir ), in combination with other anti-HIV or are breastfeeding diabetes, and increased bleeding in people medicines as prescribed by your healthcare with hemophilia have been reported in patients professional. PREZISTA should also be taken – The effects of PREZISTA on pregnant women with food (the type of food is not important). or their unborn babies are not known. You taking protease inhibitor medicines like PREZISTA and your healthcare professional will need to • Changes in body fat have been seen in some decide if taking PREZISTA is right for you patients taking anti-HIV medicines. The cause You are encouraged to report negative – You should not breastfeed if you have HIV or and long-term health effects of these conditions side effects of prescription drugs to the are taking PREZISTA are not known at this time FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. • Liver problems, which may be life-threatening, • As with other protease inhibitors, taking have been reported with the use of PREZISTA. PREZISTA may strengthen the body’s immune It was not always clear if PREZISTA caused response enabling it to begin to fight infections Please see Important Patient Information on these liver problems. Patients with liver disease that have been hidden. Patients may experience the next page. such as hepatitis B and hepatitis C may have signs and symptoms of inflammation that can Distributed by: Tibotec Therapeutics/Division of Ortho Biotech Products, L.P. include swelling, tenderness or redness Bridgewater, New Jersey 08807-0914 worsening of their liver disease with PREZISTA. ©2008 Tibotec Therapeutics 04/08 28PRZ0089 PREZIS1472 IMPORTANT PATIENT INFORMATION PREZISTA™* (darunavir) Tablets Do not take PREZISTA if you: • are allergic to darunavir or any of the other ingredients in PREZISTA Patient Information about • are allergic to ritonavir (NORVIR®) • take any of the following types of medicines because you could PREZISTA (pre-ZIS-ta) experience serious side effects: for HIV (Human Immunodeficiency Virus) Infection Generic name: darunavir (da-ROO-nuh-veer) Type of Drug Examples of Generic Names (Brand Names) Antihistamines astemizole (Hismanal®) ALERT: Find out about medicines that should NOT be taken with (to treat allergy symptoms) terfenadine (Seldane®) PREZISTA. Please also read the section “Who should not take PREZISTA?”. Ergot Derivatives dihydroergotamine Please read this information before you start taking PREZISTA. Also, (to treat migraine (D.H.E. 45®, Migranal®) read the leaflet each time you renew your prescription, just in case and headaches) ergonovine anything has changed. Remember, this leaflet does not take the place ergotamine (Wigraine®, Ergostat®, of careful discussions with your doctor. You and your doctor should ® ® discuss your treatment with PREZISTA the first time you take your Cafergot , Ergomar ) medicine and at regular checkups. You should remain under a doctor’s methylergonovine care when using PREZISTA and should not change or stop treatment Gastrointestinal Motility Agent cisapride (Propulsid®) without first talking with a doctor. (to treat some digestive conditions) WHAT IS PREZISTA? ® PREZISTA is an oral tablet used for the treatment of HIV (Human Neuroleptic pimozide (Orap ) (to treat psychiatric conditions) Immunodeficiency Virus) infection in adults. HIV is the virus that causes AIDS (Acquired Immune Deficiency Syndrome). PREZISTA Sedative/hypnotics midazolam (Versed®) is a type of anti-HIV drug called a protease (PRO-tee-ase) inhibitor. (to treat trouble with sleeping triazolam (Halcion®) HOW DOES PREZISTA WORK? and/or anxiety) PREZISTA blocks HIV protease, an enzyme which is needed for HIV to CAN PREZISTA BE TAKEN WITH OTHER MEDICATIONS?** multiply. When used with other anti-HIV medicines, PREZISTA may Tell your doctor about all the medicines you take including prescription reduce the amount of HIV in your blood (called “viral load”) and and nonprescription medicines, vitamins, and herbal supplements, increase your CD4 (T) cell count. HIV infection destroys CD4 (T) cells, including St. John’s wort (Hypericum perforatum). PREZISTA and many which are important to the immune system. The immune system helps other medicines can interact. Sometimes serious side effects will fight infection. Reducing the amount of HIV and increasing the CD4 (T) happen if PREZISTA is taken with certain other medicines (see “Who cell count may improve your immune system and, thus, reduce the risk should not take PREZISTA?”). of death or infections that can happen when your immune system is Tell your doctor if you are taking estrogen-based contraceptives. weak (opportunistic infections). PREZISTA is always taken with and at ® PREZISTA might reduce the effectiveness of estrogen-based the same time as 100 mg of ritonavir (NORVIR ), in combination with contraceptives. You must take additional precautions for birth control other anti-HIV medicines.
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