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Table S6. Names and Functions of 44 Target Genes and 4 Housekeeping Genes Assessed for Gene Expression Measurements

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Table S6. Names and Functions of 44 Target Genes and 4 Housekeeping Genes Assessed for Gene Expression Measurements Table S6. Names and functions of 44 target genes and 4 housekeeping genes assessed for gene expression measurements. Gene Gene name Function Category Reference CD45 CD45 (leukocyte common antigen) Regulation of T-cell and B-cell antigen receptor signaling Adaptive NCBI, UniProt HIVEP2 Human immunodeficiency virus typeI enhancer2 Transcription factor, V(D)J recombination, MHC enhancer binding Adaptive (Diepeveen et al. 2013) HIVEP3 Human immunodeficiency virus typeI enhancer3 Transcription factor, V(D)J recombination, MHC enhancer binding Adaptive (Diepeveen et al. 2013) IgM-lc Immunoglobulin light chain Recognition of antigen or pathogen Adaptive NCBI, UniProt Integ-Bt Integrin-beta 1 Cell signaling and adhesion of immunoglobulin Adaptive NCBI, UniProt Lymph75 Lymphocyte antigen 75 Directs captured antigens to lymphocytes Adaptive (Birrer et al. 2012) Lympcyt Lymphocyte cytosolic protein 2 Positive role in promoting T-cell development and activation Adaptive NCBI, UniProt TAP Tap-binding protein (Tapasin) Transport of antigenic peptides, peptide loading on MHC I Adaptive NCBI, UniProt AIF Allograft inflammation factor Inflammatory responses, allograft rejection, activation of macrophages Innate (Roth et al. 2012) Calrcul Calreticulin Chaperone, promotes phagocytosis and clearance of apoptotic cells Innate NCBI, UniProt Cf Coagulation factor II Blood clotting and inflammation response Innate (Birrer et al. 2012) IL8 Interleukin 8 Neutrophil chemotactic factor, phagocytosis, inflammatory activity Innate NCBI, UniProt Intf Interferon induced transmembrane protein 3 Negative regulation of viral entry into host cell, antiviral response Innate NCBI, UniProt Kin Kinesin Intracellular transport Innate (Roth et al. 2012) LectptI Lectin protein type I Pathogen recognition receptors (C-type lectin type I) Innate NCBI, UniProt LectpII Lectin protein type II Pathogen recognition receptors (C-type lectin type II) Innate NCBI, UniProt Nramp Natural resistance-assoc macrophage protein Macrophage activation Innate (Roth et al. 2012) Pepdgly Peptidoglycan recognition protein II Recognition of peptidoglycan on bacteria (gram+) cell wall Innate NCBI, UniProt Tranfe Transferrin Iron withholding (prevents bacterial outgrowth) Innate NCBI, UniProt Tspo Translocator protein Inflammatory response Innate (Roth et al. 2012) Hsp60 Heat shock protein 60 Chaperone, general stress response Innate/stress (Roth et al. 2012) Ck7 Chemokine 7 Chemotaxis for leukocytes, monocytes, neutrophils, blood cells Innate & Adaptive NCBI, UniProt Ik-cytokine Ik cytokine(RED-protein) Inhibits interferon gamma mediated downregulation of MHCII Innate & Adaptive NCBI, UniProt IL10 Interleukin 10 Regulation of macrophage activity, supresses lymphocyte response Innate & Adaptive (Birrer et al. 2012) LPS-TNF LPS-induced TNF-α factor (LITAF) Mediating cytokine (TNF-α ) expression in LPS-induced response Innate & Adaptive NCBI, UniProt Tyroprot Tyroproteinkinase Cytokine receptor signaling pathway, T and B cell activation Innate & Adaptive NCBI, UniProt C1Q-sco Recognition sub-component (C1q) C1q complex, helps in forming antigen-antibody complex Complement NCBI, Wikipedia C3 Complement component 3 Opsonization of bacteria, activation of complement system Complement (Birrer et al. 2012) C9 Complement component 9 Membrane attack complex (MAC), lysis of bacteria Complement (Roth et al. 2012) TAF8 Transcription-initiation-factor 8 Transcription factor positive regulation of transcription Transcription factor NCBI, UniProt ASH2 Histone methyltransferase (ASH2) Histone methyltransferase (SET1-ASH2 complex) Histone modification NCBI, UniProt TPR Lysine-specific demethylase 6A Histone demethylation (H3K27me3) Histone modification NCBI, UniProt JmjC-PHD Lysine-specific-demethylase 5B Histone demethylation (demethylates'Lys-4'(H3K4me)) Histone modification NCBI, UniProt NO66 Lysine-specific-histone demethylase NO66 Histone demethylation (demethylates'Lys-4'(H3K4me),(H3K36me)) Histone modification NCBI, UniProt HDAC1 Histone deacetylase 1-like Histone deacetylation (hydrolysis of N(6)-acetyl-lysine residues) Histone modification NCBI, UniProt HDAC3 Histone deacetylase 3-like Histone deacetylation (hydrolysis of N(6)-acetyl-lysine residues) Histone modification NCBI, UniProt HDAC6 Histone deacetylase 6-like Histone deacetylation (deacetylation lysine residues of core histones) Histone modification NCBI, UniProt BROMO Histone-acetyltransferase (KAT2A) Histone acetylation (KAT2B-bromodomain) Histone modification NCBI, UniProt MYST1 Histone-acetyltransferase (HAT1) Histone acetylation (MYST1-domain) Histone modification NCBI, UniProt DnMt1 DNA-Methyltransferase 1 DNA methyltransferase (C5-methylcytosine)-maintenance methylation DNA-methylation NCBI, UniProt DnMt3a DNA-Methyltransferase 3a DNA methyltransferase (C5-methylcytosine)-de novo methylation DNA-methylation NCBI, UniProt DnMt3b DNA-Methyltransferase 3b DNA methyltransferase (C5-methylcytosine)-de novo methylation DNA-methylation NCBI, UniProt HemK2 HemK-methyltransferase family member 2 DNA methyltransferase (N6-methyladenine) DNA-methylation NCBI, UniProt N6admet N(6)-adenine-specific DNA methyltransferase 2 DNA methyltransferase (N6-methyladenine) DNA-methylation NCBI, UniProt DDP-gly DDP-glycosyltransferase Metabolisation process (natural glyosidic linkages) Housekeeping NCBI, UniProt G6PD Glucose 6-phosphate dehydrogenase (G6PD) Metabolisation process (pentose phosphate pathway) Housekeeping NCBI, UniProt Ribop Ribosomal protein Translation process Housekeeping NCBI, UniProt Ubi Ubiquitin Labels regulatory proteins for degradation Housekeeping (Birrer et al. 2012) References Birrer, S.C., Reusch, T.B., Roth, O., 2012. Salinity change impairs pipefish immune defence. Fish Shellfish Immunol. 33, 1238–1248. Diepeveen, E., Roth, O., Salzburger, W. 2013. Immune-related function of the HIVEP gene family in East African cichlid fishes. G3-Genes Genom. Genet. 3, 2205–2217. Roth, O., Klein, V., Beemelmanns, A., Scharsack, J.P., Reusch, T.B., 2012. Male pregnancy and biparental immune priming. Am. Nat. 180, 802–814. .
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