Early On® Michigan Established Conditions Established conditions indicate automatic eligibility for Early On supports and services. Established conditions must be diagnosed by an appropriate health care or mental health provider and documented in a medical or other record (i.e., a Child Abuse Prevention and Treatment Act (CAPTA) referral that references a medical diagnosis). Conditions include but are not limited to, the following:

1. Congenital Anomalies 1.6. Digestive System • Other chromosomal anomalies such as 1.1. Central Nervous System • Esophageal atresia/ tracheoesophageal fistula microdeletions and • Agenesis of the corpus • Gastroschisis duplications callosum • Hirschsprung’s disease • Holoprosencephaly 3. Infectious Conditions • Omphalocele • Hydrocephalus w/o spina • Pyloric stenosis 3.1. Congenital Infections bifida • HIV/AIDS • Microcephalus 1.7. Genital & Urinary Organs • Syphilis • Spina bifida w/o • Hypospadias and • TORCH: anencephaly epispadias o Toxoplasmosis 1.2. Eye, Ear, Face, and Neck • Renal agenesis o Other agents • Craniofacial syndromes 1.8. Musculoskeletal System o Rubella such as: • Achondroplasia o Cytomegalovirus o Pierre Robin sequence • Arthrogryposis o Herpes simplex o Treacher Collins • Congenital hip dislocation • Cytomegalovirus (CMV) syndrome • Lower limb reduction • Other congenital • Anopthalmos deformities infections such as Zika • Anotia/microtia • Upper limb reduction 3.2. Acquired Infections • CHARGE syndrome deformities • Bacterial meningitis • Congenital cataract • Other congenital • Encephalitis • Craniosynostosis anomalies of the • Poliomyelitis • Micropthalmos musculoskeletal system • Viral meningitis

1.9. Other and Unspecified 1.3. Heart and Circulatory System 4. Endocrine/Metabolic • Bardet-Biedl syndrome • Aortic valve atresia and Disorders • Fragile X syndrome stenosis 4.1. Mucopolysaccharidosis • Coarctation of aorta 2. Chromosomal Anomalies • Hunter syndrome • Hypoplastic left heart • Angelman syndrome • Hurler syndrome • Patent ductus arteriosus • Cri-du-Chat syndrome • Maroteaux-Lamy (PDA) • DiGeorge syndrome syndrome • Tetralogy of Fallot (Velo-cardio-facial • Sanfilippo syndrome • Other serious congenital syndrome) • Scheie syndrome heart defects • Kleinfelter syndrome • Sly syndrome 1.4. Respiratory System • Prader-Willi syndrome • Trisomy 21 (Down 4.2. Enzyme Deficiency • Choanal atresia syndrome) • Biotinidase deficiency • Diaphragmatic hernia • Trisomy 13 (Patau • Medium-chain acyl-CoA • Lung agenesis-hypoplasia syndrome) dehydrogenase deficiency 1.5. Cleft Lip & Palate • Trisomy 18 (Edwards (MCAD) • Cleft palate w/o cleft lip syndrome) • Oculocerebrorenal • Cleft lip w/ and w/o cleft • Turner syndrome syndrome (Lowe palate • Williams syndrome syndrome)

Wednesday, June 2, 2021 1 Note: The Endocrine/Metabolic Disorders Category also includes all disorders tested for in the Michigan Newborn Screening Program. Early On® Michigan Established Conditions Established conditions indicate automatic eligibility for Early On supports and services. Established conditions must be diagnosed by an appropriate health care or mental health provider and documented in a medical or other record (i.e., a Child Abuse Prevention and Treatment Act (CAPTA) referral that references a medical diagnosis). Conditions include but are not limited to, the following:

4.3. Abnormalities of Amino Acid 4.10. Hemoglobinopathies • Intraventricular Metabolism • Sickle cell disease hemorrhage (grades 3 & • Argininosuccinic • Thalassemia (major and 4) minor) aciduria/Citrullinemia 5.1.d. Degenerative Disorders • Homocystinuria 4.11 Abnormalities of the Thyroid • Acute disseminated • Infant Phenylketonuria Hormone encephalomyelitis (PKU) • Cockayne syndrome • Maple syrup urine disease • Congenital • Friedreich’s ataxia • Methylmalonic acidemia hypothyroidism • Gangliosidosis (MMA) 4.12. Peroxisomal Disorders • Leigh’s disease • Ornithine • Adrenoleukodystrophy • Leukodystrophy transcarbamylase (OTC) (ALD) • Schilder’s disease deficiency • Cerebrohepatorenal • Tay-Sachs disease 4.4. Abnormalities of syndrome (Zellweger 5.1.e. Neurocutaneous Disorders Carbohydrate Metabolism syndrome) • Ectodermal dysplasia • Galactosemia • Peroxisomal biogenesis • Incontinentia pigmenti • Glycogen storage disease disorders • Neurofibromatosis • Pompe disease • Rhizomelic chondrodysplasia • Sturge-Weber syndrome 4.5. Abnormalities of Lipid punctata • Tuberous sclerosis Metabolism • Xeroderma pigmentosa 5. Other Disorders/Diseases • Gaucher disease 5.1.f. Malignancies • Niemann-Pick disease 5.1. Neurological Disorders • Intracranial tumors and 4.6. Abnormalities of the 5.1.a Neuromotor/Muscle other malignancies of the Purine/Pyrimidine Metabolism Disorders central nervous system • Lesch Nyhan syndrome • Cerebral palsy 5.1.g. Head and Spinal Cord • Congenital myasthenia 4.7. Abnormalities of the Trauma • Kernicterus Parathyroid • Fracture of vertebral • Muscular dystrophies column with or without • Untreated • Paralysis spinal cord lesions hyperparathyroidism • Periventricular • Shaken baby syndrome • Untreated leukomalacia hypoparathyroidism • Traumatic brain injury • Spinal muscular atrophy 4.8. Abnormalities of the Pituitary • Torticollis 5.1.h. Hypoxic/Anoxic Brain Injury • Hyperpituitary 5.1.b. Cerebrovascular Disease • Hypopituitary • Hypoxic ischemic • Cerebral arterial encephalopathy (newborn thrombosis 4.9. Abnormalities of encephalopathy) • Cerebral embolus Adrenocortical Function • Near drowning • Congenital adrenal thrombosis hyperplasia • Cerebral venous 5.2. Vision Impairment • Hyperadrenocortical thrombosis • Amblyopia function 5.1.c. Brain Hemorrhages • Cortical visual impairment (CVI) • Hypoadrenocortical • Intracranial hemorrhage function • Low vision (20/70) • Nystagmus Wednesday, June 2, 2021 2 Note: The Endocrine/Metabolic Disorders Category also includes all disorders tested for in the Michigan Newborn Screening Program. Early On® Michigan Established Conditions Established conditions indicate automatic eligibility for Early On supports and services. Established conditions must be diagnosed by an appropriate health care or mental health provider and documented in a medical or other record (i.e., a Child Abuse Prevention and Treatment Act (CAPTA) referral that references a medical diagnosis). Conditions include but are not limited to, the following:

• Retinopathy of 9. Chronic Illness • Diagnosed regulatory prematurity (ROP) disorders 9.1. Medically Fragile (stage 3 - stage 5) • Disorders of affect • Visual field loss • Renal insufficiency • Maltreatment/deprivation disorder 6. Hearing Deficiency 9.2. Medical Illness • Bronchopulmonary • Mixed disorders of • Auditory neuropathy emotional expressiveness • Bilateral or unilateral dysplasia • Cancer • Post-traumatic stress hearing loss of ≥ 25 dB at disorder (PTSD) 2+ frequencies between • Chronic hepatitis 500-4000 Hz • Connective tissue • Mixed hearing loss disorders • Permanent conductive • Cystic fibrosis hearing loss • Diabetes • Sensorineural hearing loss • Immune disorders (ex. • Waardenburg syndrome juvenile arthritis) • Failure to thrive 7. Other Fetal/Placental • Renal failure Anomalies • Very low birth weight • Twin to twin transfusion (<1500 grams or 3.3 lbs.) syndrome • Chronic asthma – • Umbilical cord prolapse moderate to severe • Intrauterine growth 8. Exposures Affecting restriction (IUGR) Fetus/Child • Small for gestational age 8.1. Prenatal (<10% weight for age) • Fetal alcohol exposure (SGA) • Fetal drug exposure 10. Developmental Delay • Diagnosed maternal phenylketonuria (PKU) 10.1. Pervasive Developmental Disorders 8.2. Postnatal • Autism spectrum disorder • Lead – venous blood lead • Childhood disintegrative level at or above disorder reference value recommended by the CDC 10.2. Rett Syndrome (currently 5 µg/dL)* 10.3. Regulatory Disorders of • Following CDC Sensory Processing recommendations for • Hyposensitive/ mercury and other hypersensitive neurotoxic chemicals • Sensory seeking/ diagnosed at elevated impulsive exposure levels 11. Mental Health Conditions

• Adjustment disorders *MDHHS rounds values 4.5 or • Depression of infancy and greater to 5 µg/dL early childhood

Wednesday, June 2, 2021 3 Note: The Endocrine/Metabolic Disorders Category also includes all disorders tested for in the Michigan Newborn Screening Program.