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April 26-27, 2019 Vancouver Convention Centre East Ballrooms Vancouver, B.C ARVO April 26-27, 2019 Vancouver Convention Centre East Ballrooms Vancouver, B.C. Program Organizers James G. Fujimoto, PhD Massachusetts Institute of Technology Cambridge, Mass. Wolfgang Drexler, PhD Medical University Vienna Vienna, Austria Joel S. Schuman, MD NYU Langone Health, NYU School of Medicine New York, N.Y. Table of Contents Topic Page # Cover…………………………………………………………………………………………………………………... 1 Sponsors………………………………………………………………………………………………………………. 4 Friday Agenda………………………………………………………………………………………………………. 5 Invited Speaker……………………………………………………………………………………………………. 6 Saturday Agenda………………………………………………………………………………………………….. 7 Program Information……………………………………………………………………………………………. 28 Thank you to our sponsors…………….…………………………………………………………………… 30 Paper Session (PDFs) OCT Angiography………………………………………………………………………………………………….. 32 Cellular and Molecular Imaging……………………………………………………………………………. 50 New and Enhanced Technologies…………………………………………………………………………. 66 Artificial Intelligence, Image Processing, and Analysis………………………………………….. 82 Poster Session (PDFs) New Technologies………………………………………………………………………………………………... 101 OCT Angiography…………………………………………………………………………………………………. 141 Artificial Intelligence…………………………………………………………………………………………….. 214 Clinical Imaging……………………………………………………………………………………………………. 287 MRI………………………………………………………………………………………………………………………. 375 Ultrasound…………………………………………………………………………………………………………… 385 Image Guided Surgery………………………………………………………………………………………….. 391 Image Processing and Image Analysis………………………………………………………………….. 399 Biomechanics………………………………………………………………………………………………………. 415 Fluorescence……………………………………………………………………………………………………….. 424 Basic Science………………………………………………………………………………………………………… 431 2019 Imaging in the Eye Conference Friday, April 26, 2019 6:00 – 8:30 PM and Saturday, April 27, 2019 8:00 AM – 5:30 PM Agenda and Program Information Vancouver Convention Centre 999 Canada Place Vancouver, BC V6C 3E1, Canada Please note that the conference syllabus will be available online only to registered attendees. A link will be sent prior to the conference to those that are registered A QRcode linking to the syllabus also will be printed on the registration receipt. ARVO gratefully acknowledges our Imaging in the Eye Conference sponsors. 2019 Imaging in the Eye Conference Agenda April 26 – 27, 2019 Vancouver Convention Centre (East) Ballroom A, B, and C (Conference Level) East 1, 2 and 3 (Meeting Level) Friday, April 26, 2019 4:00 – 9:00 pm Registration Ballroom A Foyer Welcome and Opening Remarks Ballroom A & B Invited Speaker James G. Fujimoto, PhD 6:00 – 6:15 pm Welcome/thank you to the sponsors and opening remarks Joel S. Schuman, MD, FARVO Wolfgang Drexler, PhD Thank you to our sponsors Carl Zeiss Meditec, Wasatch Photonics, Topcon and Optos, Inc. 6:15 – 6:30 pm Introduction of the Invited Speaker James G. Fujimoto, PhD Joel S. Schuman, MD, FARVO Wolfgang Drexler, PhD 6:30 – 7:15 pm OCT in the Diagnosis and Management of Philip J. Rosenfeld, MD, PhD Age-Related Macular Degeneration Bascom Palmer Eye Institute University of Miami Miller School of Medicine 7:15 – 7:25 pm Q&As 7:25 – 7:30 pm Closing remarks James G. Fujimoto, PhD Joel S. Schuman, MD, FARVO Wolfgang Drexler, PhD 7:30 – 8:30 pm Networking Reception Ballroom C We are pleased to welcome Dr. Philip J. Rosenfeld as Opening Invited Speaker at ARVO - 2019 Imaging in the Eye Conference Friday, April 26, 2019 6:30 – 7:30 pm Dr. Rosenfeld is currently Director and Professor of ophthalmology at the Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine. His primary clinical and research interests are in age-related macular degeneration (AMD). He is at the forefront of medical science having spent decades seeking effective therapies for AMD as the principal investigator and study chairman for numerous AMD clinical trials. He was instrumental in the clinical development of anti-VEGF therapies, the use of optical coherence tomography (OCT) guided treatment regimens using anti-VEGF therapy, the clinical development of OCT instruments, and the development and use of novel OCT algorithms for the diagnosis and management of macular diseases. OCT in the Diagnosis and Management of Age-Related Macular Degeneration. OCT is the gold-standard imaging technique for the diagnosis and management of both non-exudative and exudative age-related macular degeneration (AMD). The clinical convergence of OCT and vascular endothelial growth factor inhibitors (anti-VEGF therapy) led to a revolution in the treatment of neovascular and exudative ocular diseases. OCT-guided treatment with anti-VEGF therapy has become the global standard and has resulted in billions of dollars being saved by reducing the need for retreatment. OCT structural imaging combined with OCT angiographic imaging have eliminated the clinical need for dye-based angiography in managing AMD, while the use of novel algorithms has provided all the tools a clinician needs to diagnose and manage AMD. Most recently, swept-source OCT angiography has allowed us to study the choriocapillaris, a vital vascular layer that previously couldn’t be routinely imaged, yet is thought to play a pivotal role in the development and progression of AMD. 2019 Imaging in the Eye Conference Agenda April 26 – 27, 2019 Vancouver Convention Centre (East) Ballroom A, B, and C Conference Level East 1, 2 and 3 Meeting Level Saturday, April 27, 2019 7:00 am – 2:00 pm Registration Ballroom A Foyer 7:00 am – 8:00 am Morning Coffee Meeting Room Foyer 8:00 – 8:15 am Opening remarks/Thank you to the James G. Fujimoto, PhD sponsors Joel S. Schuman, MD, FARVO Wolfgang Drexler, PhD OCT Angiography Ballroom A & B Moderators: Yali Jia and Ruikang Wang 8:15 – 8:30 am Optical coherence tomography angiography Qinqin Zhang, R. Wang based capillary velocimetry on the human retina 8:30 – 8:45 am Single-volume wide-field optical coherence Xiang Wei, T. Hormel, Y. Guo, S. tomographic angiography enabled by 400- Pi, Y. Jian, Y. Jia kHz swept source laser and bidirectional scanning protocol 8:45 – 9:00 am Reference-Based OCT Angiography Richard Rosen, J.S. Andrade Romo, Perfusion Density Mapping for Identifying M.V. Castanos Toral, D.B. Zhou, P. Acute and Chronic Changes in Eyes with Garcia, A. Barash, R. Weitz, T.Y. Chui Retinopathy over Time 9:00 – 9:15 am Ultrahigh-speed OCTA imaging of the Justin Migacz, R. Zawadzki, R. Jonnal, J. choriocapillaris around drusen at 1.6 MHz Werner 9:15 – 9:30 am 3D shape representation of OCT Jiong Zhang, Qiao, Yuchuan; Sharifi Angiography images Sarabi, mona; Khansari, Maziyar M.; Gahm, Jin K.; Kashani, Amir H.; Shi, Yonggang 9:30 – 9:45 am Automatic 3D Vessel analysis framework for Mona Sharifi Sarabi, Zhang, Jiong; Gahm, Optical Coherence Tomography Jin K.; Kashani, Amir; shi, Yonggang Angiography (OCTA) 9:45 – 10:00 am Rodent retinal circulation organization and Shaohua Pi, Wei, Xiang; Cepurna, location revealed by visible light OCT William; You, Qisheng; Huang, David; Morrison, John; Jia, Yali 10:00 – 10:30 AM - Morning break and Poster Presentations East Room 1, 2, and 3 Cellular and Molecular Imaging Ballroom A & B Moderators: Kostandinka Bizheva and Bin Yang 10:30 – 10:45 am Non-contact cell-detail real-time full-field Viacheslav Mazlin, Xiao, Peng; Scholler, OCT: capabilities and potential clinical Jules; Mecê, Pedro; Grieve, Kate; Irsch, applications of the novel anterior eye Kristina; Fink, Mathias1; Boccara, Claude. imaging tool. 10:45 – 11:00 am Label-free retinal cell imaging with dynamic Jules Scholler, Groux, Kassandra; Fink, full-field OCT. Mathias; Boccara, Claude; Grieve, Kate. 11:00 – 11:15 am Label-Free Imaging of Bipolar Cell Axons in Hyungsik Lim, Bucinca-Cupallari, Festa. Fresh Retina by Second-Harmonic Generation. 11:15 – 11:30 am Molecular Landscape of the Human Macula Kevin Schey; Anderson, David M.; by High-Resolution Imaging Mass McKinney, Kate H.; Messinger, Jeffrey D.; Spectrometry. Patterson, N. H.; Spraggins, Jeffrey M.; Curcio, Christine. 11:30 - 11:45 am Real-time measurement of lamina cribrosa Ian Sigal; Lee, PoYi; Brazile, Bryn; Lam, and sclera collagen architecture and Po; Zhu, Ziyi; Hua, Yi; Yang, Bin. mechanics at sub-micron resolution. 11:45 am – 12 Extended focus, 250 kHz SD-OCT for in-vivo Zohreh Hosseinaee; HAN, LE; Marchand, noon imaging of the cellular structure of the Paul J.; Bizheva, Kostadinka. human cornea. 12:00 – 12:15 pm Non-contact, laser-based confocal Michele Pascolini, Carraro, Federico; microscope for corneal imaging. Codogno, Nicola; Minozzi, Mattia; Pajaro, Ronnye; Tiso, Christian; Menin, Giulia; Pajaro, Simone; Tanassi, Cesare. 12:15 – 1:30 PM - Lunch break and Poster Presentations East Room 1, 2, and 3 New and Enhanced Technologies Ballroom A & B Moderators: Ian Sigal and Philip Rosenfeld 1:30 – 1:45 pm Towards a handheld and low-cost full-field Helge Sudkamp; Koch, Peter; Hillmann, OCT system for aberration corrected Dierck; Münst, Michael; vom Endt, imaging. Malte; von der Burchard, claus3; Roider, Johann; Birngruber, Reginald; Hüttmann, Gereon 1:45 – 2:00 pm 250 kHz, 1.6 µm axial resolution SD-OCT for Kostadinka Bizheva; Hosseinaee, Zohreh; in-vivo imaging of the human retina. HAN, LE 2:00 – 2:15 pm Spectral reflectivity of the ex vivo mouse Danielle Harper; Glösmann, Martin; retina revealed by hyperspectral confocal Gröger, Marion; Baumann, Bernhard microscopy 2:15 – 2:30 pm Waveform analysis and vessel type Leo Puyo; Paques, Michel; Fink, identification in the retina with laser Mathias; Sahel, Jose; Atlan, Michael Doppler holography 2:30 – 2:45 pm Adaptive optics
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