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US Environmental Protection Agency Office of Programs

Chemicals Evaluated for Carcinogenic

Potential Annual Cancer Report 2020

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Chemicals Evaluated for Carcinogenic Potential Office of Pesticide Programs U.S. Environmental Protection Agency

Annual Cancer Report 2020

BACKGROUND

What is this list? The following list provides an overview of pesticide chemicals evaluated for carcinogenic potential by EPA’s Pesticide Program through September 2020. The evaluation of many of these chemicals is an ongoing process. Therefore, the information in this list may be subject to change as new and/or additional data are submitted to EPA. This list will be updated annually.

How should the information provided in this list be used? Although this list is available to the public, note that the list represents only the potential carcinogenicity hazard for the chemical with no consideration of exposure information. This list is not intended to be used independent of the full risk assessment for the chemical. When EPA completes a risk assessment on a pesticide, a variety of toxicity information, including potential for noncancer effects (e.g., , developmental and reproductive toxicity, immunotoxicity, etc.) and carcinogenicity, are considered in determining whether to register a pesticide and what requirements for use of the pesticide need to be in place to protect human health. The simple fact of being listed here does not imply that the pesticide poses a significant cancer hazard to the public from use.

What does the report date mean? The date included in the list for each chemical is the date of the most recent review of potential carcinogenicity hazard for that chemical. This date provides a key as to which set of cancer guidelines were used in the review. Note that the classification of potential carcinogenicity generally is not reevaluated unless new data are submitted.

How does EPA review for potential carcinogenicity? In evaluating and describing the potential carcinogenicity of a pesticide, EPA’s Pesticide Program follows the Agency’s Guidelines for Risk Assessment (see https://www.epa.gov/risk/guidelines-carcinogen-risk-assessment for more information). The Health Effects Division of the Pesticide Program performs an independent review of all the available evidence to determine the carcinogenic potential of pesticides.

The results of the independent review are peer-reviewed by the Cancer Assessment Review Committee. This committee recommends a “descriptor” (e.g., likely to be carcinogenic to humans, not likely to be carcinogenic to humans, suggestive evidence of carcinogenic potential) to convey the cancer hazard potential of the compound. This descriptor is also referred to as the cancer classification. The evidence for the human cancer potential and the extent to which a person might be exposed (how much time and to what quantity of the pesticide) will determine how the Agency regulates the pesticide. In some cases, EPA may request a review by the FIFRA Scientific Advisory Panel.

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What does EPA consider in its review of cancer risk? In determining the cancer-causing potential of a chemical, EPA considers the full range of available evidence. This information includes • laboratory animal findings, • studies, • structural relationships with other , and • if available, mode of carcinogenic action information and epidemiologic findings in humans.

All the information is considered in a weight-of-the-evidence approach. In this weight-of- evidence evaluation, EPA undertakes a critical analysis of each available study to determine its quality and reliability. Then the entire body of evidence is integrated and examined for consistency (repeatability of findings in studies), cohesiveness (a logical pattern of responses), and for biological plausibility (i.e., are the observed findings consistent with current understanding of carcinogenic processes). How the Agency determines the cancer potential of a compound can be found at:https://www.epa.gov/risk/guidelines-carcinogen-risk-assessment.

Most of the cancer determinations for pesticides are largely based on laboratory animal studies because, under its statutory authority, EPA requires registrants to submit an extensive range of laboratory studies on pesticides including long-term rodent cancer studies. The findings in laboratory animals are generally assumed to be relevant to humans unless there is evidence to the contrary. When human information is available, EPA would consider that information https://www.epa.gov/risk/human-health-risk-assessment.

When does EPA review pesticides for potential carcinogenicity? EPA reviews studies submitted when a pesticide is proposed for registration. Studies are required in two species (mice and rats) and two sexes (males and females), as well as a battery of mutagenicity assays. These studies are required for all pesticides used on food and some non-food pesticides that could lead to long-term exposures in humans. In future reviews of the pesticide, the cancer classification may be reevaluated if new studies have been submitted.

All existing pesticide tolerances that were in place as of August 1996 were re-assessed for their human health and environmental risks by August 2006 as required by the Food Quality Protection Act of 1996. However, if there was no new information on carcinogenicity, the compound was not re-evaluated simply to determine how it would be described under the 2005 cancer guidelines.

How have the Agency’s cancer assessment guidelines changed? There have been a number of different documents issued by the Agency for cancer evaluation.

• In 1976, EPA issued its first set of principles and interim procedures to guide evaluation of human cancer potential.

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• In 1986, EPA issued guidance, which included a letter system (A-E) for designating degree of carcinogenic potential. O In the 1986 guidelines, hazard identification and the weight-of evidence process focused on tumor findings. O See http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=54933 for a detailed description of this classification system.

• In 1996, EPA released “Proposed Guidelines for Carcinogen Risk Assessment,” which used a weight of evidence narrative and standardized descriptors to replace the 1986 alpha numeric classification to classify carcinogenic potential. O In the 1996 proposal, emphasis was placed on available mode of carcinogenic action information and discussing characterization of hazard, dose-response, and exposure assessments. O The hazard and weight of evidence process embraced an analysis of all relevant biological information and emphasized understanding the agent's mode of action in producing tumors to reduce the uncertainty in describing the likelihood of harm. O See 1996 - http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=55868.

• In 1999, EPA issued a revised version of its 1996 proposal that responded to public and peer review comments, which included: O a framework approach to evaluate the mode of action in the assessment of potential carcinogenesis. O See- http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=54932.

• In March 2005, EPA released its final Guidelines for Carcinogen Risk Assessment (EPA/630/P-03/001B). These guidelines represent the culmination of a long development process, replacing EPA’s original cancer risk assessment guidelines (1986) and its interim final guidelines (1999). Key changes included: O Five weight of evidence descriptors chosen for use in narratives (“Carcinogenic to Humans,” “Likely to Be Carcinogenic to Humans,” “Suggestive Evidence of Carcinogenic Potential,” “Inadequate Information to Assess Carcinogenic Potential,” and “Not Likely to Be Carcinogenic to Humans.”) O Emphasis on analysis of data will precede use of defaults O Improved guidance on modeling and expanded discussions of sensitive subpopulations including children (supplemental guidance) O See https://www.epa.gov/risk/guidelines-carcinogen-risk-assessment.

Why are there several different cancer classifications in the list? As discussed above, EPA’s guidelines for evaluating the potential carcinogenicity of chemicals have been updated over the years to reflect increase transparency in describing the cancer potential of a compound and to reflect the understanding of ways chemicals may cause cancer.

Not all pesticides have been evaluated under EPA’s 2005 Cancer Guidelines. Agency policy states that for risk assessments that were completed before issuance of the 2005 Guidelines, the need for a re-assessment should be determined on a case-by-case basis by the program and that the existing assessment should continue to be considered

3 scientifically sound based on the guidance used when the assessment was completed (https://www.epa.gov/risk/guidelines-carcinogen-risk-assessment.)

How can I find the basis of EPA’s decision regarding the carcinogenicity of a pesticide? The Reregistration Eligibility Decision for each pesticide contains a discussion of the available data and information used in the human health and environmental risk assessments, which includes a description of the evidence used to determine the cancer potential of the chemical. Also, the Cancer Assessment Review Committee report is available by requesting it through the Freedom of Information Act (FOIA) (https://www.epa.gov/foia).

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** Group E-Evidence of Non- 1,2,4-Triazole 288-88-0 600074 Carcinogenicity For Humans. 2/7/2006 1,3-Dibromo-5,5- Not Likely to Be Carcinogenic To dimethylhydantoin 77-48-5 006317 Humans. 8/28/2000 1,3-dichloro-5- 89415- Not Likely to Be Carcinogenic To methylhydantoin 87-2 128826 Humans. 8/28/2000 Not Likely To Be Carcinogenic To 2, 4 - DBA 94-82-6 030801 Humans. 6/13/2003 Group D--Not Classifiable As To 2,4-D + Salts & Esters 94-75-7 030001 Human Carcinogenicity. 1/29/1997 1048373- Group D--Not Classifiable As To 2,4-D Choline 72-3 051505 Human Carcinogenicity. 10/27/2011 2758-42- Not Likely To Be Carcinogenic To 2,4-DB DMA 1 030819 Humans. 7/20/2004 15165- Not Likely To Be Carcinogenic To 2,4-DP-p Salts & Esters 67-0 031402 Humans. 12/5/2013 Group C--Possible Human 2-Benzyl-4-chlorophenol 120-32-1 062201 Carcinogen. 9/5/1995 2-Fluoracetamide 640-19-7 075002 Not Required (Non-Food). 9/20/2018 Group D--Not Classifiable As To 4-aminopyridine 504-24-5 069201 Human Carcinogenicity. 8/6/2007 30560- Group C--Possible Human 19-1 103301 Carcinogen. 5/8/1985 57960- Not Likely To Be Carcinogenic To Acequinocyl 19-7 006329 Humans. 11/13/2003 63114- Group C--Possible Human Acetamide 77-2 111101 Carcinogen. 5/29/1990 135410- Not Likely To Be Carcinogenic To 20-7 099050 Humans. 12/11/2001

34256- Suggestive Evidence Of 82-1 121601 Carcinogenic Potential. 1/3/2007 135158- Not Likely To Be Carcinogenic To Acibenzolar-S-methyl 54-2 061402 Humans. 12/9/1999 Likely To Be Carcinogenic To Humans: At High Doses; Not 62476- Likely To Be Carcinogenic To sodium 59-9 114402 Humans At Low Doses. 7/9/2003

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 101007- Group D--Not Classifiable As To 06-1 129141 Human Carcinogenicity. 7/15/1996 68424- Not Likely To Be Carcinogenic To ADBAC 85-1 069105 Humans. 12/8/1999 915972- Suggestive Evidence Of Afidopyropen 17-7 026200 Carcinogenic Potential. 1/24/2018 Likely To Be Carcinogenic To Humans: At High Doses; Not 15972- Likely To Be Carcinogenic To 60-8 090501 Humans At Low Doses. 6/27/1997 Group E--Evidence Of Non- 116-06-3 098301 Carcinogenicity For Humans. 7/17/2002 67375- Group C--Possible Human Alpha- 30-8 209600 Carcinogen. 9/11/2012 865318- Not Likely To Be Carcinogenic To Ametoctradin 97-4 119210 Humans. 5/24/2017

Suggestive Evidence Of Ametryn 834-12-8 080801 Carcinogenic Potential. 12/20/2017 129909- Not Likely To Be Carcinogenic To Amicarbazone 90-6 114004 Humans. 8/10/2005 858956- 08-8, 858956- 35-1, 858954- 83-3, 124423- 84-3, 1759-53- Not Likely To Be Carcinogenic To 1 288008 Humans. 11/9/2011 150114- Not Likely To Be Carcinogenic To 71-9 005100 Humans. 7/12/2005 348635- Suggestive Evidence Of Amisulbrom 87-0 016330 Carcinogenic Potential. 12/2/2010 33089- Suggestive Evidence Of 61-1 106201 Carcinogenic Potential. 7/18/2006 Not Likely to Be Carcinogenic to Humans: at Doses that Do Not Alter Rat Thyroid Hormone Amitrole 61-82-5 004401 Homeostasis. 5/11/2006

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE****

Likely to Be Carcinogenic to Anthraquinone 84-65-1 122701 Humans. 10/31/2012 2650-18- Not Likely To Be Carcinogenic To Aquashade 2 110301 Humans. 9/27/2005 3337-71- Group C--Possible Human 1 106901 Carcinogen. 12/6/2001 1912-24- Not Likely To Be Carcinogenic To 9 080803 Humans. 12/13/2000 Avermectin (see 65195- Group E--Evidence Of Non- Emamectin Benzoate) 55-3 122804 Carcinogenicity For Humans. 6/27/1996 Data Are Inadequate For An 68049- Assessment Of Human Azafenidin 83-2 119016 Carcinogenic Potential. 10/18/1999 Not Likely To Be Carcinogenic To Azinphos-methyl 86-50-0 058001 Humans. 4/20/1998 131860- Not Likely To Be Carcinogenic To Azoxystrobin 33-8 128810 Humans. 1/14/1997 98243- Likely To Be Carcinogenic To Benalaxyl-M 83-5 113510 Humans. 12/2/2014 22781- Group E--Evidence Of Non- 23-3 105201 Carcinogenicity For Humans. 12/16/1997 Suggestive Evidence Of Carcinogenicity, But Not 1861-40- Sufficient To Assess Human 1 084301 Carcinogenic Potential. 12/27/2001 17804- Group C--Possible Human Benomyl 35-2 099101 Carcinogen. 9/21/2000 Not Likely To Be Carcinogenic To 741-58-2 009801 Humans. 6/10/1999 25057- Group E--Evidence Of Non- 89-0 275200 Carcinogenicity For Humans. 1/14/1992 177406- Likely To Be Carcinogenic To Benthiavalicarb-isopropyl 68-7 098379 Humans. 10/18/2005 156963- Not Likely To Be Carcinogenic To Benzobicyclon 66-5 215101 Humans. 4/5/2017 Not Likely To Be Carcinogenic To Benzyl Benzoate 120-51-4 009501 Humans. 6/28/2007 68359- Not Likely To Be Carcinogenic To Beta 37-5 118831 Humans. 1/27/2010

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 365400- Suggestive Evidence Of Bicyclopyrone 11-9 018986 Carcinogenic Potential. 9/10/2014 149877- Not Likely To Be Carcinogenic To Bifenazate 41-8 000586 Humans. 8/28/2001 82657- Group C--Possible Human 04-3 128825 Carcinogen. 2/19/2003 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human 584-79-2 004003 Carcinogenic Potential. 12/2/2003 125401- Not Likely To Be Carcinogenic To Bispyrabac Sodium 92-5 078906 Humans. 8/2/2001 55179- Not Likely To Be Carcinogenic To Bitertanol 31-2 117801 Humans. 11/30/2005 581809- Not Likely To Be Carcinogenic To Bixafen 46-3 128400 Humans. 7/18/2018

1303-96- Group E--Evidence Of Non- Borax 4 011102 Carcinogenicity For Humans. 11/24/1993 10043- Group E--Evidence Of Non- 35-3 011001 Carcinogenicity For Humans. 11/24/1993 7440-42- Group E--Evidence Of Non- Boron 8 128945 Carcinogenicity for Humans. 11/24/1993 12008- Not Likely To Be Carcinogenic To Boron Sodium Oxide 41-2 011107 Humans. 12/1/2015 Boron Sodium Oxide, 12280- Not Likely To Be Carcinogenic To Tetrahydrate 03-4 011103 Humans. 12/1/2015 Suggestive Evidence Of Carcinogenicity, But Not 188425- Sufficient To Assess Human Boscalid 85-6 128008 Carcinogenic Potential. 11/14/2002 Group C--Possible Human Bromacil 314-40-9 012301 Carcinogen. 1/13/1993 53404- Group C--Possible Human Bromacil, lithium salt 19-6 012302 Carcinogen. 05/9/2012 63333- Bromethalin 35-7 112802 Classification Not Available. 3/20/2020 1689-84- Group C--Possible Human 5 035301 Carcinogen. 3/12/1997 1689-99- Group C--Possible Human Bromoxynil octanoate 2 035302 Carcinogen. 4/20/2011

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 116255- Group E--Evidence Of Non- Bromuconazole 48-2 120503 Carcinogenicity For Humans. 4/24/1995 Group E--Evidence Of Non- Bronopol 52-51-7 216400 Carcinogenicity for Humans. 6/12/1995 Suggestive Evidence Of Carcinogenicity, But Not 69327- Sufficient To Assess Human 76-0 275100 Carcinogenic Potential. 3/15/2000 23184- Likely to Be Carcinogenic to 66-9 112301 Humans. 2/24/1999 134605- Not Likely To Be Carcinogenic To 64-4 122004 Humans. 7/11/2003 There Are Insufficient Data To 33629- Characterize The Cancer Risk Of Butralin 47-9 106501 Butralin. 9/5/1996 2008-41- Group E--Evidence Of Non- Butylate 5 041405 Carcinogenicity For Humans. 11/25/1992 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not Result In Enhanced Cell 75-60-5 012501 Proliferation. 6/21/2006 95465- Group E--Evidence Of Non- Cadusafos 99-9 128864 Carcinogenicity For Humans. 5/28/1992 2939-80- Group B--Probable Human Captafol 2 081701 Carcinogen. 5/19/1987 Likely To Be Carcinogenic To Humans: At Prolonged, High- Level Exposures; Not Likely To Be Carcinogenic To Humans: At Doses That Do Not Cause Cytotoxicity And Regenerative Captan 133-06-2 081301 Cell Hyperplasia. 9/22/2004 Likely To Be Carcinogenic To 63-25-2 056801 Humans. 2/12/2002 10605- Group C--Possible Human Carbendazim (MBC) 21-7 128872 Carcinogen. 4/7/1989 1563-66- Not Likely To Be Carcinogenic To 2 090601 Humans. 6/17/1997 5234-68- Not Likely To Be Carcinogenic To Carboxin 4 090201 Humans. 6/5/2003 128639- Not Likely To Be Carcinogenic To Carfentrazone-ethyl 02-1 128712 Humans. 5/16/2001

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 500008- Not Likely To Be Carcinogenic To 45-7 090100 Humans. 3/4/2009 6164-98- Group B--Probable Human 3 059701 Carcinogen. 12/20/1985 54593- Group D--Not Classifiable As To 83-8 129006 Human Carcinogenicity. 3/9/1995 Suggestive Evidence Of Carcinogenicity, But Not 122453- Sufficient To Assess Human 73-0 129093 Carcinogenic Potential. 3/18/2003 2536-31- Not Likely To Be Carcinogenic To Chlorflurenol Methyl Ester 4 098801 Humans. 7/10/2006 90982- Not Likely To Be Carcinogenic To Chlorimuron-ethyl 32-4 128901 Humans. 2/5/2009 Not Likely To Be Carcinogenic To Chlormequat chloride 999-81-5 018101 Humans. 6/12/2007 Group B--Probable Human Chloroaniline, p- 106-47-8 017203 Carcinogen. 4/27/1995 Data Are Inadequate For An 2675-77- Assessment Of Human Chloroneb 6 027301 Carcinogenic Potential. 12/18/2003 Not Likely To Be Carcinogenic To Chloropicrin 76-06-2 081501 Humans. 6/30/2010 1897-45- Likely To Be Carcinogenic To Chlorothalonil 6 081901 Humans. 10/20/1997 Group E--Evidence Of Non- Chlorpropham 101-21-3 018301 Carcinogenicity For Humans. 10/11/1994 2921-88- Group E--Evidence Of Non- 2 059101 Carcinogenicity For Humans. 11/23/1993 5598-13- Not Likely To Be Carcinogenic To Chlorpyrifos methyl 0 059102 Humans. 5/17/1999 64902- Group E--Evidence Of Non- Chlorsulfuron 72-3 118601 Carcinogenicity For Humans. 7/17/2002 1861-32- Group C--Possible Human Chlorthal-dimethyl (DCPA) 1 078701 Carcinogen. 2/10/1995 Cholecalciferol 67-97-0 202901 Classification Not Available. 3/24/2020 99129- Not Likely To Be Carcinogenic To Clethodim 21-2 121011 Humans. 9/28/2007 105512- Suggestive Evidence Of Clodinafop-propargyl 06-9 125203 Carcinogenic Potential. 2/8/2006 82697- Group C--Possible Human Clofencet (MON 21200) 71-0 128726 Carcinogen. 7/23/1996

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 74115- Group C--Possible Human Clofentezine 24-5 125501 Carcinogen. 4/3/1990 81777- Not Likely To Be Carcinogenic To 89-1 125401 Humans. 1/31/2001 1702-17- Not Likely To Be Carcinogenic To 6 117403 Humans. 12/20/1999 99607- Not Likely To Be Carcinogenic To Cloquintocet-mexyl 70-2 700099 Humans. 8/31/1999 147150- Group E--Evidence Of Non- Cloransulam-methyl 35-4 129116 Carcinogenicity for Humans. 9/30/1997 210880- Not Likely To Be Carcinogenic To 92-5 044309 Humans. 1/6/2003 6814-58- Likely To Be Carcinogenic To CMNP (Pyrazachlor) 0 207100 Humans. 9/20/2011 68603- Likely to Be Carcinogenic to Cocamide Diethanolamine 42-9 224600 Humans. 10/17/2001 20427- Group D--Not Classifiable As To Copper Compounds 59-2 023401 Human Carcinogenicity. 6/13/2006 Not Likely To Be Carcinogenic To 56-72-4 036501 Humans. 6/25/1999 Group D--Not Classifiable As To , p-Chloro-m- 59-50-7 064206 Human Carcinogenicity. 11/28/1995 15096- Group D--Not Classifiable As To Cryolite 52-3 075101 Human Carcinogenicity. 12/22/1995 99485- Suggestive Evidence Of Cumyluron 76-4 027902 Carcinogenic Potential. 6/11/2008 21725- Group C--Possible Human 46-2 100101 Carcinogen. 7/30/1991 736994- Not Likely To Be Carcinogenic To 63-1 090098 Humans. 3/7/2013 120116- Not Likely To Be Carcinogenic To Cyazofamid 88-3 085651 Humans. 6/3/2009 113136- Not Likely To Be Carcinogenic To Cyclanilide 77-9 026201 Humans. 4/9/1997 1031756- Not Likely To Be Carcinogenic To Cyclaniliprole 98-5 026202 Humans. 4/25/2017 1134-23- Not Likely To Be Carcinogenic To Cycloate 2 041301 Humans. 9/25/2003 180409- Suggestive Evidence Of Cyflufenamid 60-3 555550 Carcinogenic Potential. 12/2/2014 400882- Suggestive Evidence Of Cyflumetofen 07-7 138831 Carcinogenic Potential. 12/30/2013

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 68359- Not Likely To Be Carcinogenic To Cyfluthrin 37-5 128831 Humans. 5/21/2002 122008- Not Likely To Be Carcinogenic To Cyhalofop-butyl 85-9 082583 Humans. 12/20/2007 68085- Group D--Not Classifiable As To 85-8 128867 Human Carcinogenicity. 8/25/1993 Data Are Inadequate For An 13121- Assessment Of Human Cyhexatin 70-5 101601 Carcinogenic Potential. 4/7/2005 57966- Not Likely To Be Carcinogenic To Cymoxanil 95-7 129106 Humans. 1/2/2003 52315- Group C--Possible Human Cypermethrin 07-8 109702 Carcinogen. 9/27/1988 39515- Not Likely To Be Carcinogenic To 40-7 129013 Humans. 12/16/2016 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not 94361- Cause A Mitogenic Response In Cyproconazole 06-5 128993 The Liver. 12/4/2007 121552- Not Likely To Be Carcinogenic To Cyprodinil 61-2 288202 Humans. 1/14/1998 221667- Not Likely To Be Carcinogenic To Cyprosulfamide 31-8 877400 Humans. 2/29/2008 66215- Group E--Evidence Of Non- 27-8 121301 Carcinogenicity For Humans. 1/6/1995

1596-84- Group B--Probable Human Daminozide 5 035101 Carcinogen. 7/26/1991 Not Likely To Be Carcinogenic To Dantochlor (BCDMH) 118-52-5 028501 Humans. 8/14/2000 Group D--Not Classifiable As To Dazomet 533-74-4 035602 Human Carcinogenicity. 12/7/1993 Group D--Not Classifiable As To DEET 134-62-3 080301 Human Carcinogenicity. 1/4/1996 52918- Not Likely To Be Carcinogenic To 63-5 097805 Humans. 9/9/2003 944263- Demiditraz 65-4 577501 Not Required (Non-food). 4/11/2013 13684- Group E--Evidence Of Non- Desmedipham 56-5 104801 Carcinogenicity For Humans. 11/20/1995 Not Likely To Be Carcinogenic To 333-41-5 057801 Humans. 6/17/1997

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE****

1918-00- Not Likely To Be Carcinogenic To 9 029801 Humans. 8/16/2005 104040- Group D--Not Classifiable As To Dicamba BAPMA Salt 79-1 100094 Human Carcinogenicity. 3/29/2016 1194-65- Group C--Possible Human Dichlobenil 6 027401 Carcinogen. 7/18/1995 37764- Not Likely To Be Carcinogenic To Dichlormid 25-3 900497 Humans. 11/15/2005 2008-58- Group D--Not Classifiable As To Dichlorobenzamide, 2,6- 4 027402 Human Carcinogenicity. 11/28/1995 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human 62-73-7 084001 Carcinogenic Potential. 3/1/2000 51338- Likely To Be Carcinogenic To Diclofop-methyl 27-3 110902 Humans. 5/24/2000 Suggestive Evidence Of Dicloran 99-30-9 031301 Carcinogenic Potential. 9/5/2006 145701- Not Likely To Be Carcinogenic To Diclosulam 21-9 129122 Humans. 11/9/1999 Group C--Possible Human 115-32-2 010501 Carcinogen. 6/24/1992 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human 141-66-2 035201 Carcinogenic Potential. 10/18/1999 Didecyl dimethyl ammonium chloride 7173-51- Group E--Evidence Of Non- (DDAC) 5 069149 Carcinogenicity For Humans. 4/11/2000 87130- Suggestive Evidence Of Diethofencarb 20-9 112102 Carcinogenic Potential. 8/27/2015 119446- Suggestive Evidence Of Difenoconazole 68-3 128847 Carcinogenic Potential. 3/1/2007 43222- Group E--Evidence Of Non- Difenzoquat methyl sulfate 48-6 106401 Carcinogenicity For Humans. 5/24/1994 35367- Group E--Evidence Of Non- 38-5 108201 Carcinogenicity For Humans. 4/27/1995 109293- Not Likely To Be Carcinogenic To Diflufenzopyr 97-2 005108 Humans. 3/7/2017 109293- Not Likely To Be Carcinogenic To Diflufenzopyr Sodium 98-3 005107 Humans. 3/7/2017

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 87674- Group C--Possible Human 68-8 129051 Carcinogen. 9/3/2014 163515- Group C--Possible Human Dimethenamid-P 14-8 120051 Carcinogen. 9/3/2014 55290- Group C--Possible Human Dimethipin 64-7 118901 Carcinogen. 1/5/1990 Group C--Possible Human 60-51-5 035001 Carcinogen. 3/26/2002 110488- Not Likely To Be Carcinogenic To Dimethomorph 70-5 268800 Humans. 5/13/1998 Suggestive Evidence Of Dimethoxane 828-00-2 001001 Carcinogenic Potential. 12/21/2000 Not Required Based On The Dimethyl Disulfide, DMDS 624-92-0 029088 Proposed Use Pattern. 12/18/2018 Group D--Not Classifiable To Dimethyl ether 115-10-6 900382 Humans Carcinogenicity. 1/12/1994 16079- Not Likely to Be Carcinogenic To Dimethylhydantoin 88-2 006315 Humans. 8/28/2000 39300- Group E--Evidence Of Non- Dinocap 45-3 036001 Carcinogenicity For Humans. 6/22/1994 Group C--Possible Human 88-85-7 037505 Carcinogen. 6/19/1986 165252- Not Likely To Be Carcinogenic To 70-0 044312 Humans. 3/5/2004 Not Likely To Be Carcinogenic To Diphenylamine 122-39-4 038501 Humans. 4/1/1997 Group E--Evidence Of Non- dibromide 85-00-7 032201 Carcinogenicity For Humans. 5/12/1994 Disodium Not Likely To Be Carcinogenic To methanearsonate 144-21-8 013802 Humans. 7/26/2000 Group E--Evidence Of Non- 298-04-4 032501 Carcinogenicity For Humans. 4/21/1997 3347-22- Suggestive Evidence Of Dithianon 6 099201 Carcinogenic Potential. 2/23/2006 97886- Group E--Evidence Of Non- (MON 7200) 45-8 128994 Carcinogenicity for Humans. 5/29/1997

Diuron 330-54-1 035505 Known/Likely. 5/8/1997 2439-10- Not Likely To Be Carcinogenic To Dodine 3 044301 Humans. 1/24/2008 274671- Not Likely To Be Carcinogenic To Ecolyst 61-3 069089 Humans. 10/19/1999

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** Emamectin Benzoate 137512- Not Likely To Be Carcinogenic To (Deoxy Avermectin) 74-4 122806 Humans. 3/19/1998 Not Likely To Be Carcinogenic To 115-29-7 079401 Humans. 1/31/2000 Not Likely To Be Carcinogenic To 145-73-3 038901 Humans. 10/23/2008 66330- Not Likely To Be Carcinogenic To Endothall Amine Salt 88-9 038905 Humans. 12/09/2015 2164-07- Not Likely To Be Carcinogenic To Endothall dipotassium salt 0 038904 Humans. 12/09/2015 106325- 08-0, 133855- Likely To Be Carcinogenic To Epoxiconazole 98-8 123909 Humans. 1/24/2001 Suggestive Evidence Of Carcinogenicity, But Not 28434- Sufficient To Assess Human Esbiothrin 00-6 004007 Carcinogenic Potential. 12/2/2003 66230- Group E--Evidence Of Non- 04-4 109303 Carcinogenicity For Humans. 7/1/1996 162650- Suggestive Evidence Of Ethaboxam 77-3 090205 Carcinogenic Potential. 3/23/2006 55283- Group C--Possible Human Ethalfluralin 68-6 113101 Carcinogen. 9/14/1994 16672- Group D--Not Classifiable As To 87-0 099801 Human Carcinogenicity. 8/15/1994 Group E--Evidence Of Non- 563-12-2 058401 Carcinogenicity For Humans. 1/26/1994 181587- Suggestive Evidence Of Ethiprole 01-9 005550 Carcinogenic Potential. 10/28/2010 26225- Group D--Not Classifiable As To Ethofumesate 79-6 110601 Human Carcinogenicity. 2/24/1994 13194- Likely To Be Carcinogenic To Ethoprop 48-4 041101 Humans. 10/7/1998 Data Are Inadequate For An Assessment Of Human Ethoxyquin 91-53-2 055501 Carcinogenic Potential. 9/11/2019

Ethyl dipropylthiocarbamate Not Likely To Be Carcinogenic To (EPTC) 759-94-4 041401 Humans. 8/31/1999

15

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** Group B--Probable Human Ethylene thiourea (ETU) 96-45-7 600016 Carcinogen. 7/7/1999 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not 80844- Alter Rat Thyroid Hormone 07-1 128965 Homeostasis. 2/8/2006 153233- Not Likely To Be Carcinogenic To Etoxazole 91-1 107091 Humans. 8/7/2003 131807- Not Likely To Be Carcinogenic To Famoxadone 57-3 113202 Humans. 4/16/2003 161326- Not Likely To Be Carcinogenic To Fenamidone 34-7 046679 Humans. 7/12/2002 22224- Group E--Evidence Of Non- 92-6 100601 Carcinogenicity For Humans. 11/23/1993 60168- Not Likely To Be Carcinogenic To 88-9 206600 Humans. 9/5/2001 120928- Not Likely To Be Carcinogenic To Fenazaquin 09-8 044501 Humans. 5/15/2007 114369- Group C--Possible Human Fenbuconazole 43-6 129011 Carcinogen. 4/15/1996 13356- Group E--Evidence Of Non- Fenbutatin-oxide 08-6 104601 Carcinogenicity For Humans. 3/2/1993 126833- Not Likely To Be Carcinogenic To Fenhexamide 17-8 090209 Humans. 3/4/1999 Group E--Evidence Of Non- 122-14-5 105901 Carcinogenicity For Humans. 7/13/1993 9015-56- Suggestive Evidence Of Fenoxaprop-ethyl 9 128701 Carcinogenic Potential. 7/29/2013 72490- Likely To Be Carcinogenic To 01-8 125301 Humans. 12/22/1997 517875- Suggestive Evidence Of Fenpicoxamid (XDE-777) 34-2 082566 Carcinogenic Potential. 8/24/2017 39515- Not Likely To Be Carcinogenic To 41-8 127901 Humans. 12/22/2003 67306- Suggestive Evidence Of Fenpropidin 00-7 012305 Carcinogenic Potential. 6/9/2009 67564- Not Likely To Be Carcinogenic To Fenpropimorph 91-4 121402 Humans. 10/19/2005 473798- Not Likely To Be Carcinogenic To Fenpyrazamine 59-3 090109 Humans. 10/31/2012 134098- Not Likely To Be Carcinogenic To Fenpyroximate 61-6 129131 Humans. 2/19/1997

16

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** Group E--Evidence Of Non- 55-38-9 053301 Carcinogenicity For Humans. 3/11/1996 51630- Group E--Evidence Of Non- 58-1 109301 Carcinogenicity For Humans. 2/10/2003 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human 14484– Carcinogenic Potential; Based Ferbam 64–1 034801 On Ziram Studies. 4/6/2000 120068- Group C--Possible Human 37-3 129121 Carcinogen. 7/18/1995 104040- Not Likely To Be Carcinogenic To 78-0 119011 Humans. 11/16/2005 Suggestive Evidence Of Carcinogenicity, But Not 158062- Sufficient To Assess Human Flonicamid 67-0 128016 Carcinogenic Potential. 2/24/2005 145701- Not Likely To Be Carcinogenic To Florasulam 23-1 129108 Humans. 5/31/2007 1390661- Not Likely To Be Carcinogenic To Florpyrauxifen-benzyl 72-9 030093 Humans. 6/1/2017 69806- Not Likely To Be Carcinogenic To 50-4 122805 Humans. 6/27/2019 79241- Not Likely To Be Carcinogenic To Fluazifop-P-Butyl 46-6 122809 Humans. 6/27/2019 Suggestive Evidence Of Carcinogenicity, But Not 79622- Sufficient To Assess Human Fluazinam 59-6 129098 Carcinogenic Potential. 3/29/2001 272451- Not Likely To Be Carcinogenic To 65-7 027602 Humans. 4/3/2008 181274- Not Likely To Be Carcinogenic To Flucarbazone-sodium 17-9 114009 Humans. 7/19/2000 131341- Group D--Not Classifiable As To Fludioxonil 86-1 071503 Human Carcinogenicity. 9/19/1996 318290- Suggestive Evidence Of Fluensulfone 98-1 050410 Carcinogenic Potential. 5/7/2014 142459- Not Likely To Be Carcinogenic To Flufenacet (Thiaflumide) 58-3 121903 Humans. 7/16/1997 101463- Not Likely To Be Carcinogenic To 69-8 108203 Humans. 8/15/2006 188489- Not Likely To Be Carcinogenic To Flufenpyr-ethyl 07-8 108853 Humans. 6/8/2003

17

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 69770- Not Likely To Be Carcinogenic To 45-2 036007 Humans. 3/6/2012 62924- Not Likely To Be Carcinogenic To Flumetralin 70-3 123001 Humans. 6/21/2007 98967- Group E--Evidence Of Non- Flumetsulam (XRD-498) 40-9 129016 Carcinogenicity For Humans. 3/24/1993 87546- Group E--Evidence Of Non- Flumiclorac pentyl 18-7 128724 Carcinogenicity For Humans. 9/7/1994 103361- 09-7, 141490- Not Likely To Be Carcinogenic To Flumioxazin 50-8 129034 Humans. 2/22/2001 2164-17- Group C--Possible Human Fluometuron 2 035503 Carcinogen. 8/28/1996 239110- Not Likely To Be Carcinogenic To Fluopicolide 15-7 027412 Humans. 12/12/2006 658066- Not Likely To Be Carcinogenic To Fluopyram 35-4 080302 Humans. 5/8/2014 361377- Not Likely To Be Carcinogenic To Fluoxastrobin 29-9 028869 Humans. 1/24/2005 951659- Not Likely To Be Carcinogenic To Flupyradifurone 40-8 122304 Humans. 8/5/2014 59756- Group E--Evidence Of Non- Fluridone 60-4 112900 Carcinogenicity For Humans. 7/1/1985 81406- Not Likely To Be Carcinogenic To 37-3 128968 Humans. 6/26/2003

Fluroxypyr acid (see also 69377- Not Likely To Be Carcinogenic To PC Code 128968) 81-7 128959 Humans. 6/26/2003 56425- Not Likely To Be Carcinogenic To Flurprimidol 91-3 125701 Humans. 9/29/2005 117337- Likely To Be Carcinogenic To Fluthiacet methyl 19-6 108803 Humans. 11/20/1998 958647- Not Likely To Be Carcinogenic To Flutianil 10-4 014018 Humans. 11/1/2017 66332- Group E--Evidence Of Non- Flutolanil 96-5 128975 Carcinogenicity For Humans. 6/9/1994 76674- Not Likely To Be Carcinogenic To Flutriafol 21-0 128940 Humans. 6/1/2009 Not Likely To Be Carcinogenic To 907204- Humans: Below A Defined Dose Fluxapyroxad 31-3 138009 Range. 6/9/2011

18

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** Not Likely To Be Carcinogenic To Humans: At Doses That Do Not Cause An Irritation Response In Folpet 133-07-3 081601 The Mucosal Epithelium. 10/13/2010 108731- Not Likely To Be Carcinogenic To 70-0 123802 Humans. 11/3/2005 Group E--Evidence Of Non- 944-22-9 041701 Carcinogenicity for Humans. 11/10/1993 68157- Not Likely To Be Carcinogenic To Forchlorfenuron 60-8 128819 Humans. 3/11/2008 173159- Not Likely To Be Carcinogenic To Formasulfuron 57-4 122020 Humans. 9/19/2001 23422- Group E--Evidence Of Non- hydrochloride 53-9 097301 Carcinogenicity For Humans. 5/20/1996 39148- Not Likely To Be Carcinogenic To Fosetyl-Al 24-8 123301 Humans. 4/22/1999 98886- Not Likely To Be Carcinogenic To Fosthiazate 44-3 129022 Humans. 9/15/2003 Likely To Be Carcinogenic To Furfural 98-01-1 043301 Humans. 2/6/2014 Likely To Be Carcinogenic To Furfuryl Alcohol 98-00-0 643300 Humans. 2/6/2014 121776- Likely To Be Carcinogenic To Furilazole (MON 13900) 33-8 911596 Humans. 10/15/1999 60568- Group B--Probable Human Furmecyclox 05-0 122601 Carcinogen. 7/3/1985 1373256- G77 () 33-7 128662 Not Required (Non-food). 5/23/2018 76703- Not Likely To Be Carcinogenic To Gamma Cyhalothrin 62-3 128807 Humans. 3/1/2004 22248- Group C--Possible Human Gardona 79-9 083702 Carcinogen. 12/21/2016 1405-41- Not Likely To Be Carcinogenic To Gentamicin Sulfate 0 006325 Humans. 3/21/2007 77182- Not Likely To Be Carcinogenic To -ammonium 82-2 128850 Humans. 5/17/1999 Not Likely to Be Carcinogenic to Glutaraldehyde 111-30-8 043901 Humans. 5/18/2006 1071-83- Not Likely To Be Carcinogenic To 6 417300 Humans. 12/12/2017 9034-40- GnRH 6 116800 Classification Not Available. 5/2/2019

19

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 943831- Not Likely To Be Carcinogenic To Halauxifen-methyl 98-9 117501 Humans. 3/21/2016 Halosulfuron methyl 100784- Not Likely To Be Carcinogenic To (MON 1200) 20-1 128721 Humans. 2/26/1998 69806- Group B--Probable Human Haloxyfop-methyl 40-2 125201 Carcinogen. 9/18/1989 79983- Group C--Possible Human Hexaconazole 71-4 128925 Carcinogen. 1/21/1999 Hexavalent Chromium 18540- 021101; Likely to Be Carcinogenic to (CrVI) 29-9 068302 Humans. 7/1/2009 51235- Group D--Not Classifiable As To 04-2 107201 Human Carcinogenicity. 7/27/1994 78587- Likely To Be Carcinogenic To Hexythiazox 05-0 128849 Humans. 9/2/2009 135590- Not Likely To Be Carcinogenic To HOE107892 91-9 811800 Humans. 11/24/1998 67485- Group C--Possible Human 29-4 118401 Carcinogen. 3/28/1991 Group C--Possible Human Hydrogen Cyanamide 420-04-2 014002 Carcinogen. 9/15/1993

Hydrogen Cyanide 74-90-8 045801 Classification Not Available. 9/18/2018 41096- Group D--Not Classifiable As To 46-2 486300 Human Carcinogenicity. 6/8/1995 10004- Not Likely To Be Carcinogenic To Hymexazol 44-1 129107 Humans. 12/3/2015 35554- Likely To Be Carcinogenic To Imazalil 44-0 111901 Humans. 12/7/1999 58594- Likely To Be Carcinogenic To Imazalil sulfate 72-2 111902 Humans. 7/5/2018 81405- Group D--Not Classifiable As To Imazamethabenz 85-8 128842 Human Carcinogenicity. 6/11/1987 114311- Not Likely To Be Carcinogenic To Imazamox 32-9 129171 Humans. 2/27/1997 81334- Group E--Evidence Of Non- 60-3 129041 Carcinogenicity For Humans. 9/27/1995 81334- Group E--Evidence Of Non- 34-1 128821 Carcinogenicity For Humans. 10/5/1995 81335- Not Likely To Be Carcinogenic To Imazaquin Acid 37-7 128848 Humans. 10/31/2005 81335- Not Likely To Be Carcinogenic To Imazethapyr 77-5 128922 Humans. 1/31/2002

20

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 122548- Not Likely To Be Carcinogenic To Imazosulfuron 33-8 118602 Humans. 3/13/2009 105827- Group E--Evidence Of Non- 78-9 129099 Carcinogenicity For Humans. 11/10/1993 72963- 72-5 004006 Not Required (Non-food). 8/31/2016 950782- Not Likely To Be Carcinogenic To 86-2 080818 Humans. 4/22/2010 173584- Not Likely To Be Carcinogenic To 44-6 067710 Humans. 7/17/2000 Sodium Metabisulfite Is Currently Not Classifiable (Group 3) As To Its Inorganic Sulfites (Sodium 7681-57- Carcinogenicity To Humans Metabisulfite) 4 111409 (IARC 1992). 3/23/2020 Sulfur Dioxide Is Currently Not Classifiable (Group 3) As To Its Inorganic Sulfites (Sulfur 7446-09- Carcinogenicity To Humans Dioxide) 05 077601 (IARC 1992). 3/23/2020

1352994- Not Likely To Be Carcinogenic To Inpyrfluxam 67-2 090114 Humans. 7/1/2020 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not Alter Rat Thyroid Hormone Iodomethane 74-88-4 000011 Homeostasis. 11/10/2005 144550- Not Likely To Be Carcinogenic To Iodosulfuran 36-7 122021 Humans. 1/5/2004 125225- Not Likely To Be Carcinogenic To Ipoconazole 28-7 125618 Humans. 5/28/2008 36734- Likely To Be Carcinogenic To Iprodione 19-7 109801 Humans. 2/26/1998 140923- Likely To Be Carcinogenic To Iprovalicarb 17-7 098359 Humans. 4/11/2002 25311- Group E--Evidence Of Non- Isofenphos 71-1 109401 Carcinogenicity For Humans. 1/13/1998 875915- Not Likely To Be Carcinogenic To Isofetamid 78-9 270000 Humans. 9/24/2014 Group C--Possible Human Isophorone 78-59-1 047401 Carcinogen. 9/2/1999 881685- Likely To Be Carcinogenic To Isopyrazam 58-1 129222 Humans. 2/2/2011

21

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 224049- Not Likely To Be Carcinogenic To Isotialnil 04-1 129130 Humans. 9/25/2019 82558- Suggestive Evidence Of Isoxaben 50-7 125851 Carcinogenic Potential. 10/7/2008 163520- Not Likely To Be Carcinogenic To Isoxadifen-ethyl 33-0 823000 Humans. 1/29/2001 141112- Likely To Be Carcinogenic To Isoxaflutole 29-0 123000 Humans. 9/30/1997 6980-18- Not Likely To Be Carcinogenic To Kasugamycin 3 230001 Humans. 8/17/2005 55965- Group D--Not Classifiable As To Kathon 886 84-9 107106 Human Carcinogenicity. 5/18/1995 119515- Not Likely To Be Carcinogenic To KBR 3023 38-7 070705 Humans. 6/9/1999 143390- Likely To Be Carcinogenic To Kresoxim-methyl 89-0 129111 Humans. 8/19/1999 Likely To Be Carcinogenic To Humans: At High Doses; Not 77501- Likely To Be Carcinogenic To 63-4 128888 Humans At Low Doses. 10/17/2006 91465- Group D--Not Classifiable As To Lambda cyhalothrin 08-6 128897 Human Carcinogenicity. 9/12/2002 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human 58-89-9 009001 Carcinogenic Potential. 11/29/2001 Group C--Possible Human 330-55-2 035506 Carcinogen. 11/20/2001 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human 121-75-5 057701 Carcinogenic Potential. 4/28/2000 Group E--Evidence Of Non- Maleic hydrazide 123-33-1 051501 Carcinogenicity For Humans. 11/10/1993 8018-01- Group B--Probable Human Mancozeb 7 014504 Carcinogen. 7/7/1999 173662- Not Likely To Be Carcinogenic To Mandestrobin 97-0 036603 Humans. 4/25/2016 374726- Not Likely To Be Carcinogenic To Mandipropamid 62-2 036602 Humans. 1/21/2009 12427- Group B--Probable Human Maneb 38-2 014505 Carcinogen. 7/7/1999

22

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** MB46513 (photodegradate 120067- Not Likely to Be Carcinogenic to of Fipronil) 83-6 600050 Humans. 12/6/2000 Not Likely To Be Carcinogenic To MCPA + Salts 94-74-6 030501 Humans. 10/29/2003 Not Likely To Be Carcinogenic To MCPB Acid 94-81-5 019201 Humans. 10/1/2008 6062-26- Not Likely To Be Carcinogenic To MCPB Sodium Salt 6 019202 Humans. 10/24/2005 Suggestive Evidence Of Carcinogenicity, But Not 16484- Sufficient To Assess Human -P 77-8 129046 Carcinogenic Potential. 3/13/2003 70630- Not Likely To Be Carcinogenic To Mefenoxam 17-0 113502 Humans. 5/17/2000 1417782- Not Likely To Be Carcinogenic To Mefentrifluconazole 03-6 122000 Humans. 4/11/2019

53780- Not Likely To Be Carcinogenic To Mefluidide 34-0 114001 Humans. 5/30/2007 Group D--Not Classifiable As To Melamine 108-78-1 777201 Human Carcinogenicity. 7/21/1993 110235- Likely To Be Carcinogenic To Mepanipyrim 47-7 288203 Humans. 4/20/2004 24307- Not Likely To Be Carcinogenic To Mepiquat Chloride 26-4 109101 Humans. 2/19/2003 Meptyldinocap (DE- Group E--Evidence Of Non- 126/Dinocap II) 131-72-6 036000 Carcinogenicity For Humans. 3/17/2009 Group C--Possible Human Mercaptobenzothiazole, 2- 149-30-4 051701 Carcinogen. 11/19/1992 208465- Not Likely To Be Carcinogenic To Mesosulfuron methyl 21-8 122009 Humans. 3/4/2004 104206- Not Likely To Be Carcinogenic To 82-8 122990 Humans. 4/12/2001 139968- Not Likely To Be Carcinogenic To 49-3 281250 Humans. 1/24/2006 57837- Group E--Evidence Of Non- Metalaxyl 19-1 113501 Carcinogenicity for Humans. 4/20/1994 Suggestive Evidence Of Metaldehyde 108-62-3 053001 Carcinogenic Potential. 6/23/2005 Likely To Be Carcinogenic To 137-42-8 039003 Humans. 5/14/2009 125116- Not Likely To Be Carcinogenic To Metconazole 23-6 125619 Humans. 4/14/2006

23

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 10265- Not Likely To Be Carcinogenic To 92-6 101201 Humans. 2/12/1998 Group C--Possible Human 950-37-8 100301 Carcinogen. 2/19/1988 2032-65- Group D--Not Classifiable As To 7 100501 Human Carcinogenicity. 3/2/1993 403640- Methiozolin 27-7 090088 Not Required (Non-Food). 5/30/2019

16752- Group E--Evidence Of Non- 77-5 090301 Carcinogenicity For Humans. 10/25/1996 161050- Not Likely To Be Carcinogenic To Methoxyfenozide 58-4 121027 Humans. 7/1/1999 Not Likely To Be Carcinogenic To Methyl bromide 74-83-9 053201 Humans. 6/20/2001 Methyl isothiocyanate 6317-18- Likely to be Carcinogenic To (MITC) 6 068103 Humans 2/22/2018 Not Likely To Be Carcinogenic To Methyl 298-00-0 053501 Humans. 12/1/1997 9006-42- Group B--Probable Human Metiram 2 014601 Carcinogen. 7/7/1999 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not 240494- Cause A Mitogenic Response In 70-6 109709 The Liver. 7/26/2007

51218- Not Likely To Be Carcinogenic To 45-2 108801 Humans. 11/6/2017 220899- Suggestive Evidence Of Metrafenone 03-6 000325 Carcinogenic Potential. 7/6/2006 21087- Group D--Not Classifiable As To 64-9 101101 Human Carcinogenicity. 5/16/1995 74223- Not Likely To Be Carcinogenic To Metsulfuron methyl 64-6 122010 Humans. 3/14/2002 7786-34- Not Likely To Be Carcinogenic To 7 015801 Humans. 5/17/2000 Group C--Possible Human MGK 264 113-48-4 057001 Carcinogen. 6/7/1995 Suggestive Evidence Of Carcinogenicity, But Not 2212-67- Sufficient To Assess Human Molinate 1 041402 Carcinogenic Potential. 12/14/2000

24

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 609346- Not Likely To Be Carcinogenic To Momfluorothrin 29-4 016331 Humans. 12/2/2014

71526- Likely To Be Carcinogenic To MON 4660 07-3 600046 Humans. 12/9/1999 Monosodium acid 2163-80- Not Likely To Be Carcinogenic To methanearsonate (MMA) 6 013803 Humans. 7/26/2000 Not Likely To Be Carcinogenic To Morpel 326 136-45-8 047201 Humans. 5/12/2015 5902-95- Not Likely To Be Carcinogenic To MSMA- salt 4 013806 Humans. 12/14/2000 88671- Group E--Evidence Of Non- Myclobutanil 89-0 128857 Carcinogenicity For Humans. 6/16/1994 15165- Not Likely to Be Carcinogenic to NAA potassium salt 79-4 056003 Humans. 3/14/2012 Group E--Evidence Of Non- 300-76-5 034401 Carcinogenicity For Humans. 8/31/1994 Naphthalene 91-20-3 055801 Classification Not Available. 12/26/2018

15299- Not Likely To Be Carcinogenic To Napropamide 99-7 103001 Humans. 7/7/2005 Group D--Not Classifiable As To Naptalam Sodium Salt 132-67-2 030703 Human Carcinogenicity. 9/7/1994 2122-70- Not Likely To Be Carcinogenic To Napthalene Acetates 5 056008 Humans. 3/5/2009 Not Likely To Be Carcinogenic To Nicarbazin 330-95-0 085712 Humans. 12/2/2015 111991- Group E--Evidence Of Non- Nicosulfuron 09-4 129008 Carcinogenicity For Humans. 9/1/1998 Not Likely To Be Carcinogenic To Humans at doses that do not result in CAR activation as 1929-82- indicated by Cyp2b10 Nitrapyrin 4 069203 expression. 5/8/2018 27314- Group C--Possible Human Norflurazon 13-2 105801 Carcinogen. 11/2/1990 116714- Not Likely To Be Carcinogenic To Novaluron 46-6 124002 Humans. 2/4/2004

121451- Likely To Be Carcinogenic To Noviflumuron 02-3 118204 Humans. 10/17/2017

25

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** Not Likely To Be Carcinogenic To Humans: Quantification Of Cancer Risk Is Not Required Since The NOAEL Selected For The Chronic RfD Would Address The Concerns For The Precursor Orthophenylphenol (see Events Leading To Development also PC 064104) 90-43-7 064103 Of Bladder And Liver Tumors. 10/12/2005 Not Likely To Be Carcinogenic To Humans: Quantification Of Cancer Risk Is Not Required Since The NOAEL Selected For The Chronic RfD Would Address Orthophenylphenol, the Concerns For The Precursor Sodium salt (see also PC Events Leading To Development 064103) 132-27-4 064104 Of Bladder And Liver Tumors. 10/12/2005 213464- Suggestive Evidence Of Orthosulfamuron 77-8 108209 Carcinogenic Potential. 10/26/2006 19044- Likely To Be Carcinogenic To Oryzalin 88-3 104201 Humans. 6/25/2003 19666- Likely To Be Carcinogenic To Oxadiazon 30-9 109001 Humans. 5/1/2001 77732- Group C--Possible Human Oxadixyl 09-3 126701 Carcinogen. 1/4/1989 23135- Group E--Evidence Of Non- 22-0 103801 Carcinogenicity For Humans. 11/5/1996 Not Likely To Be Carcinogenic To Oxydemeton-methyl 301-12-2 058702 Humans. 7/24/1997 42874- Likely To Be Carcinogenic To Oxyfluorfen 03-3 111601 Humans. 4/20/2010 Group D--Not Classifiable As To Human Oxytetracycline 79-57-2 006304 Carcinogenicity. 11/1/2016 2058-46- Group D--Not Classifiable As To Oxytetracycline 0 006308 Human Carcinogenicity. 12/18/1992 7179-50- Group D--Not Classifiable As To Oxytetracycline Calcium 2 006321 Human Carcinogenicity. 11/1/2016 2439-01- Group B--Probable Human Oxythioquinox 2 054101 Carcinogen. 2/15/1996 76738- Group D--Not Classifiable As To Paclobutrazol 62-0 125601 Human Carcinogenicity. 6/23/1994 Not Likely To Be Carcinogenic To Paradichlorobenzene 106-46-7 061501 Humans. 6/5/2007

26

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 30525- Group B--Probable Human Paraformaldehyde 89-4 043002 Carcinogen. 9/24/2008 Group D--Not Classifiable As To Paranitrophenol 100-02-7 056301 Human Carcinogenicity. 5/14/1996 1910-42- Group E--Evidence Of Non- dichloride 5 061601 Carcinogenicity For Humans. 4/19/2000 Group C--Possible Human Parathion, ethyl- 56-38-2 057501 Carcinogen. 9/11/1991 1114-71- Not Likely To Be Carcinogenic To Pebulate 2 041403 Humans. 12/7/1998 40487- Group C--Possible Human 42-1 108501 Carcinogen. 7/24/1992 494793- Suggestive Evidence Of Penflufen 67-8 100249 Carcinogenic Potential. 3/30/2011 Suggestive Evidence Of Carcinogenicity, But Not 219714- Sufficient To Assess Human Penoxulam 96-2 119031 Carcinogenic Potential. 3/24/2004 Pentachloronitrobenzene Group C--Possible Human (PCNB) 82-68-8 056502 Carcinogen. 12/18/1992 Group B--Probable Human Pentachlorophenol 87-86-5 063001 Carcinogen. 1/3/1991 183675- Suggestive Evidence Of Penthiopyrad 82-3 090112 Carcinogenic Potential. 10/18/2011 52645- Suggestive Evidence Of 53-1 109701 Carcinogenic Potential. 1/13/2020 106700- Suggestive Evidence Of Pethoxamid 29-2 090208 Carcinogenicity Potential 4/15/2019 13684- Group D--Not Classifiable As To Phenmedipham 63-4 098701 Human Carcinogenicity. 4/28/1993 Suggestive Evidence Of Carcinogenicity, But Not 32289- Sufficient To Assess Human PHMB 58-0 111801 Carcinogenic Potential. 7/16/2003 Group E--Evidence Of Non- 298-02-2 057201 Carcinogenicity For Humans. 12/30/1993 2310-17- Not Likely To Be Carcinogenic To 0 097701 Humans. 8/12/1999 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human 732-11-6 059201 Carcinogenic Potential. 10/27/1999

27

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 13171- Group C--Possible Human 21-6 018201 Carcinogen. 5/31/1989 96182- Group E--Evidence Of Non- Phostebupirim 53-5 129086 Carcinogenicity For Humans. 4/27/1993 1918-02- Group E--Evidence Of Non- Acid 1 005101 Carcinogenicity For Humans. 4/1/1994 Picloram Acid Ethylhexyl 26952- Group E--Evidence Of Non- Ester 20-5 005103 Carcinogenicity for Humans. 4/1/1994 Picloram Acid Potassium 2545-60- Group E--Evidence Of Non- Salt 0 005104 Carcinogenicity for Humans. 4/1/1994 Picloram Acid 6753-47- Group E--Evidence Of Non- Triisopropanolamine Salt 5 005102 Carcinogenicity for Humans. 4/1/1994 117428- Suggestive Evidence Of Picoxystrobin 22-5 129200 Carcinogenic Potential. 11/15/2011 Data Are Inadequate For An 243973- Assessment Of Human Pinoxaden 20-8 147500 Carcinogenic Potential. 5/18/2005 Group C--Possible Human Piperonyl butoxide 51-03-6 067501 Carcinogen. 6/7/1995

23103- Likely To Be Carcinogenic To 98-2 106101 Humans. 7/13/2005 29232- Pirimiphos-methyl 93-7 108102 Cannot Be Determined. 1/29/1998 Data Are Inadequate for an 214710- Assessment of Human Polymeric Betaine 34-6 103679 Carcinogenic Potential. 10/3/2006 Likely To Be Carcinogenic To 7778-50- 068302; Humans: See Hexavalent Potassium dichromate 9 021101 Chromium (CrVI). 7/1/2009 23031- Not Likely To Be Carcinogenic To 36-9 128722 Humans. 6/27/2003 86209- Group D--Not Classifiable As To Primisulfuron-methyl 51-0 128973 Human Carcinogenicity. 5/3/1990 67747- Group C--Possible Human 09-5 128851 Carcinogen. 7/1/1988 32809- Group B--Probable Human Procymidone 16-8 129044 Carcinogen. 4/5/1991 29091- Group C--Possible Human Prodiamine 21-2 110201 Carcinogen. 6/10/1991 41198- Group E--Evidence Of Non- 08-7 111401 Carcinogenicity For Humans. 2/6/1996

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 127277- Not Likely To Be Carcinogenic To Prohexadione 53-6 112600 Humans. 4/14/2000 1610-18- Group D--Not Classifiable As To 0 080804 Human Carcinogenicity. 11/25/1992 7287-19- Group E--Evidence Of Non- Prometryn 6 080805 Carcinogenicity For Humans. 7/26/1994

23950- Not Likely To Be Carcinogenic To Pronamide 58-5 101701 Humans. 12/2/2014 1918-16- Likely To Be Carcinogenic To 7 019101 Humans. 10/16/1997 Propamocarb 25606- Not Likely To Be Carcinogenic To hydrochloride 41-1 119302 Humans. 5/31/2000 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human 709-98-8 028201 Carcinogenic Potential. 6/19/2001 2312-35- Group B--Probable Human Propargite 8 097601 Carcinogen. 7/23/1992 Not Likely To Be Carcinogenic To Propazine 139-40-2 080808 Humans. 12/8/2005 31218- Not Likely To Be Carcinogenic To Propetamphos 83-4 113601 Humans. 10/31/1998

60207- Group C--Possible Human Propiconazole 90-1 122101 Carcinogen. 9/11/1992

12071- Likely to Be Carcinogenic to Propineb 83-9 522200 Humans. 2/11/2013

Group B--Probable Human 114-26-1 047802 Carcinogen. 6/17/1996

181274- Not Likely To Be Carcinogenic To Propoxycarbazone-Sodium 15-7 122019 Humans. 4/6/2004

Group B--Probable Human Propylene Oxide 75-56-9 042501 Carcinogen. 7/31/2006

189278- Suggestive Evidence Of Proquinazid 12-4 044502 Carcinogenic Potential. 4/24/2013

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** Data Are Inadequate For An 94125- Assessment Of Human Prosulfuron 34-5 129031 Carcinogenic Potential. 1/24/2000 178928- Not Likely To Be Carcinogenic To Prothioconazole 70-6 113961 Humans. 12/31/2007 1228284- Not Likely To Be Carcinogenic To Pydiflumetofen 64-7 090110 Humans. 12/13/2017 123312- Likely To Be Carcinogenic To Pymetrozine 89-0 101103 Humans. 9/22/1999 175013- Not Likely To Be Carcinogenic To Pyraclostrobin 18-0 099100 Humans. 2/15/2007 129630- Likely To Be Carcinogenic To Pyraflufen ethyl 19-9 030090 Humans. 10/8/2002 365400- Suggestive Evidence Of Pyrasulfotole 11-9 000692 Carcinogenic Potential. 5/17/2007 1698-60- Not Likely To Be Carcinogenic To Pyrazon 8 069601 Humans. 7/28/2005 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not 8003-34- Cause A Mitogenic Response In 7 069001 The Liver. 2/14/2008 96489- Group E--Evidence Of Non- Pyridaben 71-3 129105 Carcinogenicity For Humans. 5/11/1994 179101- Not Likely To Be Carcinogenic To Pyridalyl 81-6 295149 Humans. 8/3/2004 55512- Not Likely To Be Carcinogenic To Pyridate 33-9 128834 Humans. 1/24/2000 Not Likely To Be Carcinogenic To Humans: At Levels That Do Not 337458- Alter Rodent Hormone Pyrifluquinazon 27-2 555555 Homeostasis. 6/21/2012 Not Likely To Be Carcinogenic To Humans at Doses that Do Not 53112- Alter Rat Thyroid Hormone Pyrimethanil 28-0 288201 Homeostasis. 1/3/2012 688046- Not Likely To Be Carcinogenic To Pyriofenone 61-9 028828 Humans. 12/14/2011 95737- Group E--Evidence Of Non- 68-1 129032 Carcinogenicity For Humans. 8/15/1995 123343- Group C--Possible Human Pyrithiobac-sodium 16-8 078905 Carcinogen. 9/5/1995

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE****

Not Likely To Be Carcinogenic To Humans: At Doses That Do Not Cause Urinary Bladder Calculi 447399- Formation Resulting In Cellular Pyroxasulfone 55-5 090099 Damage Of The Urinary Tract. 5/17/2011 422556- Not Likely To Be Carcinogenic To Pyroxsulam 08-9 108702 Humans. 7/12/2007 84087- Group D--Not Classifiable As To Quinchlorac 01-4 128974 Human Carcinogenicity. 8/26/1992 124495- Not Likely To Be Carcinogenic To Quinoxyfen 18-7 055459 Humans. 1/28/2003 76578- Group D--Not Classifiable As To Quizalofop ethyl 14-8 128711 Human Carcinogenicity. 3/17/1988 100646- Group D--Not Classifiable As To Quizalofop-P-ethyl 51-3 128709 Human Carcinogenicity. 8/18/2016 10453- Likely To Be Carcinogenic To 86-8 097801 Humans. 5/25/2005 122931- Not Likely To Be Carcinogenic To Rimsulfuron 48-0 129009 Humans. 2/19/1998 Group E--Evidence Of Non- 83-79-4 071003 Carcinogenicity For Humans. 10/5/1988 372137- Not Likely To Be Carcinogenic To (BAS 800 H) 35-4 118203 Humans. 7/22/2009 Suggestive Evidence Of Carcinogenicity, But Not 28434- Sufficient To Assess Human S-Bioallethrin 00-6 004004 Carcinogenic Potential. 12/2/2003 874967- Suggestive Evidence Of Sedaxane 67-6 129223 Carcinogenic Potential. 5/4/2017 74051- Not Likely To Be Carcinogenic To 80-2 121001 Humans. 3/19/2003 Not Likely To Be Carcinogenic To 122-34-9 080807 Humans. 4/14/2005 87392- Not Likely To Be Carcinogenic To s-Metolachlor 12-9 108800 Humans. 11/6/2017

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE****

50723- Group E--Evidence Of Non- Sodium bentazon 80-3 103901 Carcinogenicity For Humans. 1/14/1992 Sodium Cyanide 143-33-9 074002 Classification Not Available. 9/18/2018

Sodium Fluoroacetate 62-74-8 075003 Not Required (Non-Food). 9/20/2018

7775-19- Not Likely To Be Carcinogenic To Sodium Metaborate 1 011104 Humans. 12/1/2015 15922- Group D--Not Classifiable As To Sodium omadine 78-8 088004 Human Carcinogenicity. 5/16/1995 Sodium Tetraborate 1330-43- Not Likely To Be Carcinogenic To Anhydrous 3 011112 Humans. 12/1/2015 Sodium Tetraborate 12179- Not Likely To Be Carcinogenic To Pentahydrate 04-3 011110 Humans. 12/1/2015 1072957- Suggestive Evidence Of Solatenol 71-1 122305 Carcinogenic Potential. 9/30/2014 187166- 40-1; 187166- Not Likely To Be Carcinogenic To Spinetoram 15-0 110008 Humans. 9/20/2007 131929- Not Likely To Be Carcinogenic To 60-7 110003 Humans. 7/18/2002 148477- Likely To Be Carcinogenic To Spirodiclofen 71-8 124871 Humans. 6/10/2004 283594- Not Likely To Be Carcinogenic To Spiromesifen 90-1 024875 Humans. 5/21/2008 203313- Not Likely To Be Carcinogenic To Spirotetramat 25-1 392201 Humans. 3/26/2009 118134- Not Likely To Be Carcinogenic To Spiroxamine 30-8 120759 Humans. 11/14/2003 7745-89- Starlicide 3 009901 Not Required (Non-food). 7/17/2018 Streptomycin 57-92-1 006306 Classification Not Available. 12/12/2017

3810-74- Streptomycin Sesquisulfate 0 006310 Classification Not Available. 12/12/2017

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** Strychnine 57-24-9 076901 Classification Not Available. 3/18/2020 122836- Group E--Evidence Of Non- 35-5 129081 Carcinogenicity For Humans. 5/7/1996 81591- Group E--Evidence Of Non- Sulfosate 81-3 128501 Carcinogenicity For Humans. 7/26/1994 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not Cause Urinary Bladder Calculi 141776- Formation Resulting In Cellular Sulfosulfuron 32-1 085601 Damage Of The Urinary Tract. 12/16/2008

946578- Suggestive Evidence Of 00-3 005210 Carcinogenic Potential. 4/26/2012 2699-79- Not Likely To Be Carcinogenic To Sulfuryl fluoride 8 078003 Humans. 5/24/2001 35400- Group E--Evidence Of Non- Sulprofos 43-2 111501 Carcinogenicity for Humans. 3/26/1996 26002- Not Likely To Be Carcinogenic To Sumithrin 80-2 069005 Humans. 5/30/2006 102851- Not Likely To Be Carcinogenic To Tau-fluvalinate 06-9 109302 Humans. 9/29/2005 21564- Group C--Possible Human TCMTB (Busan 72) 17-0 035603 Carcinogen. 8/28/1996 107534- Group C--Possible Human Tebuconazole 96-3 128997 Carcinogen. 9/15/1993 112410- Group E--Evidence Of Non- 23-8 129026 Carcinogenicity For Humans. 8/29/1994 Suggestive Evidence Of Carcinogenicity, But Not 119168- Sufficient To Assess Human 77-3 090102 Carcinogenic Potential. 7/15/2002

34014- Group D--Not Classifiable As To 18-1 105501 Human Carcinogenicity. 3/1/1993 83121- Suggestive Evidence Of Teflubenzuron 18-0 129048 Carcinogenic Potential. 7/1/2015 79538- Not Likely To Be Carcinogenic To 32-2 128912 Humans. 5/30/2012 Suggestive Evidence Of Telone 542-75-6 029001 Carcinogenic Potential. 9/26/2019

33

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 335104- Suggestive Evidence Of Tembotrione 84-2 012801 Carcinogenic Potential. 5/22/2007 Data Are Inadequate For An 149979- Assessment Of Human Tepraloxydim 41-9 121005 Carcinogenic Potential. 2/27/2001 5902-51- Group E--Evidence Of Non- Terbacil 2 012701 Carcinogenicity For Humans. 9/30/1994 13071- Group E--Evidence Of Non- 79-9 105001 Carcinogenicity For Humans. 3/9/1994 5915-41- Group D--Not Classifiable As To 3 080814 Human Carcinogenicity. 8/24/1994 Group C--Possible Human Terbutryn 886-50-0 080813 Carcinogen. 3/3/1988 2593-15- Likely To Be Carcinogenic To Terrazole 9 084701 Humans. 4/4/2019 Likely To Be Carcinogenic To 961-11-5 083701 Humans. 3/7/2002 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not 112281- Cause A Mitogenic Response In Tetraconazole 77-3 120603 The Liver. 4/2/2013

7696-12- Group C--Possible Human 0 069003 Carcinogen. 12/11/1989 Likely To Be Carcinogenic To Humans: At High Doses; Not Likely To Be Carcinogenic To Thiabendazole 148-79-8 060101 Humans At Low Doses. 3/8/2002

111988- Likely To Be Carcinogenic To 49-9 014019 Humans. 10/31/2012 153719- Not Likely To Be Carcinogenic To 23-4 060109 Humans. 6/13/2005 117718- Suggestive Evidence Of Thiazopyr (MON 13200) 60-2 129100 Carcinogenic Potential. 12/6/2007 51707- Not Likely To Be Carcinogenic To Thidiazuron 55-2 120301 Humans. 8/31/2005 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not Cause Urinary Bladder Calculi 317815- Formation Resulting In Cellular Thiencarbazone-methyl 83-1 015804 Damage Of The Urinary Tract. 2/29/2008

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PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE****

79277- Not Likely To Be Carcinogenic To Thifensulfuron methyl 27-3 128845 Humans. 12/12/2006 28249- Group D--Not Classifiable As To Thiobencarb (Bolero) 77-6 108401 Human Carcinogenicity. 6/10/1996 Thiocyclam hydrogen 31895- Group D--Not Classifiable As To oxalate 22-4 128868 Human Carcinogenicity. 9/15/1994 59669- Group B--Probable Human Thiodicarb 26-0 114501 Carcinogen. 6/10/1996 23564- Likely To Be Carcinogenic To Thiophanate-methyl 05-8 102001 Humans. 8/24/1999 Not Likely To Be Carcinogenic To Thiram 137-26-8 079801 Humans. 4/14/2003 1220411- Not Likely To Be Carcinogenic To Tiafenacil 29-9 012311 Humans. 7/13/2020 330459- Not Likely To Be Carcinogenic To Tioxazafen (MON 102100) 31-9 074752 Humans. 9/5/2019

57018- Tolclofos-methyl 04-9 128905 Not Required (Non-food). 3/22/2012 129558- Not Likely To Be Carcinogenic To Tolfenpyrad 76-5 090111 Humans. 6/3/2010 928783- Suggestive Evidence Of Tolpyralate 29-3 573101 Carcinogenic Potential. 1/18/2017

Likely To Be Carcinogenic To Tolyfluanid 731-27-1 309200 Humans. 6/18/2002 Not Likely To Be Carcinogenic To Humans: At Doses That Do Not 210631- Alter Rat Thyroid Hormone Topramezone 68-8 123009 Homeostasis. 5/19/2005 Suggestive Evidence Of Carcinogenicity, But Not 87820- Sufficient To Assess Human Tralkoxydim 88-0 121000 Carcinogenic Potential. 6/30/2004

118712- 89-3 129140 Not Required (Non-food). 6/1/2018

35

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 43121- Group C--Possible Human Triadimefon 43-3 109901 Carcinogen. 12/4/1996 55219- Group C--Possible Human Triadimenol 65-3 127201 Carcinogen. 1/29/1988 2303-17- Group C--Possible Human Triallate 5 078802 Carcinogen. 1/12/1994 82097- Group E--Evidence Of Non- Triasulfuron 50-5 128969 Carcinogenicity For Humans. 2/27/1991 112143- Not Likely To Be Carcinogenic To Triazamate 82-5 128100 Humans. 12/1/1997 101200- Group C--Possible Human Tribenuron methyl 48-0 128887 Carcinogen. 7/14/1989 Likely To Be Carcinogenic To Humans: At High Doses; Not Likely To Be Carcinogenic To Tribufos 78-48-8 074801 Humans At Low Doses. 5/22/1997

14275- Group D--Not Classifiable As To Tributyltin maleate 57-1 083118 Human Carcinogenicity. 3/31/2005 Likely To Be Carcinogenic To Humans: At High Doses; Not Likely To Be Carcinogenic To Trichlorfon 52-68-6 057901 Humans At Low Doses. 7/15/1999

55335- Group D--Not Classifiable As To 06-3 116001 Human Carcinogenicity. 5/9/1996 3380-34- Not Likely To Be Carcinogenic To 5 054901 Humans. 1/4/2008 41814- Not Likely To Be Carcinogenic To Tricyclazole 78-2 120201 Humans. 4/1/2014 58138- Group C--Possible Human Tridiphane 08-2 123901 Carcinogen. 4/22/1986 141517- Not Likely To Be Carcinogenic To Trifloxystrobin 21-7 129112 Humans. 6/16/1999 290332- Not Likely To Be Carcinogenic To Trifloxysulfuron 10-4 119009 Humans. 7/22/2003 Not Likely To Be Carcinogenic To Humans: At Dose Levels That Do Not Cause A Significant 1263133- Induction In CYP2B Enzyme Triflumezopyrim 33-0 129210 Activity. 8/10/2017 68694- Group E--Evidence Of Non- Triflumizole 11-1 128879 Carcinogenicity For Humans. 8/10/1993

36

PC REPORT CHEMICAL CAS NO.* CANCER CLASSIFICATION*** CODE** DATE**** 1582-09- Group C--Possible Human 8 036101 Carcinogen. 4/11/1986 126535- Group C--Possible Human Triflusulfuron-methyl 15-7 129002 Carcinogen. 5/28/1996 Suggestive Evidence Of Carcinogenicity, But Not 26644- Sufficient To Assess Human Triforine 46-2 107901 Carcinogenic Potential. 6/29/2004

95266- Not Likely To Be Carcinogenic To Trinexapac-Ethyl 40-3 112602 Humans. 9/5/2008 Triphenyltin hydroxide Group B--Probable Human (TPTH) 76-87-9 083601 Carcinogen. 5/24/1990 131983- Not Likely To Be Carcinogenic To Triticonazole 72-7 125620 Humans. 6/15/2006 55406- Not Likely to Be Carcinogenic to Troysan polyphase (IPBC) 53-6 107801 Humans. 12/4/1996 Group B--Probable Human UDMH 57-14-7 600018 Carcinogen. 7/26/1991 111578- Group E--Evidence Of Non- UMP-488 (PAL 6000) 32-6 129025 Carcinogenicity for Humans. 5/6/1994 83657- Group C--Possible Human Uniconazole 22-1 128976 Carcinogen. 10/11/1990 83657- Group C--Possible Human Uniconazole-P 17-4 138976 Carcinogen. 10/11/1990 283159- Not Likely To Be Carcinogenic To Valifenalate 90-0 128200 Humans. 5/2/2019

50471- Group C--Possible Human 44-8 113201 Carcinogen. 6/20/2000 1330-20- Not Likely To Be Carcinogenic To Xylene (dimethyl-benzene) 7 086802 Humans. 3/6/2009 52315- Group C--Possible Human Zeta-Cypermethrin 07-8 129064 Carcinogen. 9/27/1988 Suggestive Evidence Of Carcinogenicity, But Not Sufficient To Assess Human Ziram 137-30-4 034805 Carcinogenic Potential. 2/6/2003

156052- Not Likely To Be Carcinogenic To Zoxamide 68-5 101702 Humans. 2/7/2001

37

*CAS No: a chemical identifier designated by the Chemical Abstracts Service **PC Code: a unique chemical identifier used by the Office of Pesticide Programs ***Cancer Classification: Simple descriptors used to express conclusions regarding the carcinogenic hazard potential of a chemical based on all relevant information, which is usually laboratory studies. These phases changed over time, as the Agency's guidance for carcinogenicity assessment was updated and revised.

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