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(Kera-Diet ) Hydrolysate on Hair and Nails. Randomized, Placebo

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(Kera-Diet ) Hydrolysate on Hair and Nails. Randomized, Placebo J Cosmo Trichol 2020, 5:1 Journal of Cosmetology & Trichology DOI: 10.4172/2471-9323.1000140 Research Article Open Access Efficacy and Safety of a Natural Keratin (Kera-Diet®) Hydrolysate on Hair and Nails. Randomized, Placebo-and Benchmark-Controlled Clinical Trial on Healthy Females Part 2 Vincenzo Nobile*, EnzaCestone1, Renaud Sergheraert2, Francesco Tursi1, Joel Duperray2 1Complife Italia Srl, Via Mons.Angelini 21, 27028 San Martino Siccomario, Pavia, Italy 2BCF® Life Sciences, Boisel, 52140 Pleucadeuc, France *Corresponding author: Nobile V, Department of Dermatology, San Martino Siccomario, Pavia, Italy, Tel: 0039 0382 25504, Fax: 0039 0382 536006, E-mail: [email protected] Received: February 03, 2020; Accepted: February 13, 2020; Published: February 21, 2020 Copyright: © 2020 NobileV, et al. This is an open-access article distributed under the terms of the creative commons attribution license which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. Abstract Telogen effluvium (TE) is one of the commonest occurrences in a trichology clinic, with patients claiming excessive hair shedding. TE is so frequent and worrying as to convey urgently the patient to the dermatologist and to extend the complaint even to social blogs on the web worldwide. In its acute (aTE) form, telogen effluvium clinical course duration does not exceed 6 months. The excessive hair shedding typical of aTE is triggered when a large number of hair in the growing phase of the hair cycle (anagen) prematurely and abruptly enter the resting phase (telogen). The duration of the interruption of the anagen hair growth is not noticed by the patient since the mitotically inactive nature of telogen. Hair shedding is noticed by patients only when hair re-enter the anagen phase and a new hair displace the telogen hair from the follicle. The interruption of mitosis, leading to aTE, may occur on account of chemotherapeutic drugs, acute febrile illness, postpartum hormonal changes, hypothyroidism, iron/zinc deficiency, seasonal variation, crash dieting, low protein intake, and malnutrition. aTE can occur in people of any age and ethnicity and is considered to be a quite common condition in either sex. Women are more likely to have lowered quality of life and restricted social contacts as compared to men as a result of hair loss even if the loss of hair becomes a matter of concern in all individuals irrespective of age and sex. Nail plate fragility is a common condition affecting up to 20% of the population, especially women over 50 years of age, characterized by roughness of the surface of the nail plate, tendency of the nail to peel and split, and fragility of the distal nail. According to causative factor, 2 forms of nail fragility can be distinguished: a primary "idiopathic or brittle nail syndrome" form (BNS) and NF secondary to different causes such as inflammatory nail disorders, infections, systemic diseases and general conditions, traumas and alteration of the nail hydration. Nails affected by BNS appear ragged, thin, and dull. The clinical features of BNS include horizontal splits within the nail plate (onychoschizia) and increased longitudinal ridging or splitting (onychorrhexis): the impairment of intercellular adhesive factors of the nail plate is expressed as onychoschizia; while the involvement of the nail matrix is expressed as onychorrhexis. The majority of subjects experiencing BNS indicate that these nail abnormalities are painful, impair daily activities, and may have a negative impact on occupational abilities. In BNS oral supplementation, trace elements and amino acids (especially cysteine) have been reported to be useful to ameliorate the nail plate condition. BNS is also associated with the presence of depressive disorders, indicating a possible impact on the quality of life of those who experience them, similarly to what occurs with hair loss perception. aTE can occur in people of any age and ethnicity and is considered to be a quite common condition in these risk factors are not life threatening, they have a deep impact on the Keywords: Telogeneffluvium; Brittle nail syndrome; Onychoschizia; affected subject’s wellness and its social relationship. Beyond their Nail matrix; Hypothyroidism; Anagen; Hair growth; Keratin biological function, both hair and nails function as a visual advertisement of the subject health, social status and mood. The effects of hair loss on Introduction the subject psychology is nowadays well-documented. In 2001, Hair and nails are daily exposed to challenging conditions, including Williamson and collaborators reported a decrease of the quality of the life lifestyle, environmental factors, and adverse medications effects. All and restricted social contacts, correlated with symptoms of depression, in these conditions have an impact on both the hair and nails appearance subjects of both sexes affected by various forms of hair loss [2] with a [1]. Although most of the hair and nails altered condition caused by more severe psychological impact among women than in men [3, 4]. The J Cosmo Trichol, an open access journal Volume 6 • Issue 1 • 1000165 ISSN:2471-9323 Citation: Nobile V (2020) A Comparative Study between Topical 5% Minoxidil and Topical “Redensyl, Capixyl, and Procapil” Combination in Men with Androgenetic Alopecia. J Cosmo Trichol 6: 140. doi:10.4172/2471-9323.1000165 same applies to nails. In 1966, DeJong and collaborators, in a study with dermatologist. According to the inclusion criteria laid down in the study 1728 patients with psoriasis reported that the the 51.8% the subjects had protocol, the subjects were of general good health, aged between 30 and pain caused by the nail changes and that the most of them were 60 years old, had no alimentary/eating disorders (i.e. bulimia, restricted in their daily activities [5]. Elewski showed in 93 patients with psychogenic eating disorders, etc.), and known history of metabolic onychomycosis that 92% reported negative psychosocial and/or physical syndrome. The study excluded food intolerances/allergy, effects and 44% had a negative self-image [6]. Acute telogen effluvium pharmacological treatments known to interfere with the test product or (aTE) and the brittle nails syndrome (BNS) are the commonest having an effect on metabolism, participation in another similar study, occurrences in a trichology/dermatology clinic. Subjects affected by unwillingness or inability to comply with the requirements of the study aTE claim excessive hair shedding extending their compliant even to protocol, history for radiotherapy/chemotherapy treatments, and scalp social blogs on the web worldwide [7]. aTE can occur in people of any surgery (e.g. hair transplantation), pregnancy or intention to become age and ethnicity and is a quite common condition in either sex. The pregnant, lactation, The study further excluded subjects using food BNS is a common condition involving nail plate fragility. BNS affect up supplements containing active ingredients having an influence on hair to 20% of the population especially women over 50 years of age. loss/growth and on nail plate, oestrogen-progesterone contraception or According to causative factor, two forms of nail fragility can be hormonal treatment therapies within 3 months before study start, identified: a primary "idiopathic or brittle nail syndrome" form (BNS) systemic treatments (e.g. retinoids, anti- mitotic, cytotoxic drugs other and nail fragility (NF) secondary to different causes such as than antineoplastic, anti-androgens, androgens, anti-epileptic agents, inflammatory nail disorders, infections, systemic diseases and general interferon alpha) affecting the hair growth taken for more than 4 conditions, traumas and alteration of the nail hydration [8]. The clinical consecutive weeks during the last 24 weeks before inclusion visit, and features of BNS include horizontal splits within the nail plate systemic or local androgenetic alopecia treatment or product, taken or (onychoschizia) and increased longitudinal ridging or splitting applied (Minoxidil, Aminexil, Finasteride, Dutasteride, cosmetic solution (onychorrhexis): the impairment of intercellular adhesive factors of the or capsules with vitamin B, zinc, caffeine) for more than 4 consecutive nail plate is expressed as onychoschizia; while the involvement of the weeks during the last 24 weeks before the inclusion visit, and subjects nail matrix is expressed as onychorrhexis [9]. having excessive and/or fluctuating hair shedding for more than 6 months. Subjects were asked to refrain from change their hair style and to The use of dietary supplements is increasingly reported worldwide, and cut their nails 7 days before and after each checkpoint. Hair dyeing was scientists and health professionals agree that dietary supplements can be not allowed during all the study period under certain conditions beneficial to human health. An online survey All subjects were given a three-month supply of the test product (Kera- on health professionals, conducted online by Ipsos Public Affairs for the Diet®, BCF® Life Sciences, Boisel, 56140Pleucadeuc, France). Subjects Council for Responsible Nutrition (CRN), found that the 66% of the were instructed to ingest 4 four capsules per day (1000 mg/day), two at surveyed dermatologist (n=300) recommend dietary supplements to breakfast and two at dinner, for a total period of 90 days. After the basal patients [10]. Despite the relationship between the nutrition
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