conferenceseries.com 1482nd Conference
PCOS 2017
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Scientific Tracks & Abstracts Day 1
Page 21 conferenceseries.com Melinda Luke, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
The link between maternal PCOS women and autism Melinda Luke Institute of Integrative Nutrition, USA
large-scale study out of Sweden suggests that women with PCOS have an increased risk of giving birth to children with autism Aspectrum disorder (ASD). As they reported online December 8th, 2015 in Molecular Psychiatry, the team looked at 23,748 individuals with ASD and nearly 209,000 unaffected individuals, all born in Sweden between 1984 and 2007. The group found that ASD was 59 percent more prevalent in children born to women with PCOS a relationship that was independent of PCOS complications such as increased neonatal distress or C-section delivery. The apparent PCOS link may seem odd at first glance. But, it fits with a theory for autism development that centers on androgens–male sex hormones. Many researchers suspect conditions that boost androgen levels or otherwise upset hormone balance during pregnancy may alter fetal brain formation in ways that contribute to social deficits, delayed language and other autism–associated symptoms later in life. The diagram is showing the break in the hormonal layers in the brain. Although ASD is five times more common in boys than in girls, babies born to mothers with PCOS in the study had the same risk regardless of the sex of the child. A different research shows having elevated levels of steroid hormones, (testosterone, progesterone, and cortisol) are found in ASD children. Because some of these hormones are produced in much higher quantities in males than in females, this may help us explain why autism is more common in males. In my lecture, I will talk about ways to minimize the risk and discuss my personal story.
Biography Melinda Luke has her expertise in helping PCOS women from personal experience. She has an Undergrad in Medical Administration and Coding. After starting a family, she has worked for Insulite Laboratories, where she talked with PCOS women all over the world. Then, she went to the Institute of Integrative Nutrition where she has received a certification in Health Coaching. Helping PCOS women is her passion. Her websites and health coaching programs are packed with the latest information.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 23 conferenceseries.com Jimi Sayo, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Hypnosis, neuroscience and epigenetics: Manage PCOS by rewiring conscious beliefs and behavior Jimi Sayo London PCOS Talks Meetup, UK
Statement of the Problem: The motivation and belief system in a PCOS patient to adopt radical lifestyle choices to manage PCOS are challenged by discouraging messages and daily setbacks. The truth is, we’re all hypnotists, affecting people with what we say and how we say it, influenced by suggestions from the media, medical experts, friends and family. The mind will selectively hold on to messages and memories that suit an unconscious but outdated benefit. With PCOS, she who was the fittest and most fertile in famine conditions of the past, was key to the survival of her clan. Today, the ancient advantage has turned on her, creating mental and physical lethargy, stuttering fertility and a struggling endocrine system in a body under-engineered for the gastronomical and toxic excesses of the 21st century. Conclusion & Significance: The good news is the woman with PCOS has the genetic advantages of a warrior mind and body if her unconscious is rewired to reverse the hormonal chaos. Her biological fate is not set in stone, thanks to epigenetics and the power of suggestion through hypnosis, psycho sensory therapies like Havening (amygdala depotentiation therapy), EFT and EMDR. These tools change the thinking environment with a positive knock on effect on behavior and life-style choices that can create and sustain a life free of PCOS. Hypnosis has been used medically since the ancient Sleep Temples of 1700’s Egypt, where deep trance was combined with curative suggestions. In the 1850s, the surgeon, James Esdaile, performed amputations under hypnosis. In the 1960s, David Elman taught hypnosis to medics. Havening is challenging thinking on healing. It’s the 21st Century, and my presentation will demonstrate what the body can do, when the mind tuned for healing.
Biography Jimi Sayo has practiced as a Hypnotherapist and Wellness Coach for ten years. She motivates women by reprogramming their desire for change and empowerment. She specializes in education based weight control, coaching her clients to a greater understanding between their nutritional choices, and aligning their past with their present. She combines her skills in therapeutic hypnotherapy, Neuro Linguistic Programming, and Havening to coach her clients to greater self-awareness. She is the host of the online PCOS Summit, and runs the London PCOS Talks Meetup in the United Kingdom.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 24 conferenceseries.com Sara Jacobsen, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
The relationship between surviving childhood abuse and developing PCOS later in life: A Case Study Sara Jacobsen Conceive With Joy, USA
Statement of the problem: One in every 10 women is diagnosed with infertility in the USA. Researchers have studied the relationship between women experiencing childhood abuse and developing PMS, uterine fibroids, endometriosis and pelvic pain. However, not much research has been done on the relationship between experiencing childhood abuse and developing PCOS. This presentation will highlight the potential relationship between experiencing childhood abuse and developing PCOS. This presentation will detail how I, the presenter, healed myself of PCOS through healing my childhood sexual abuse, and through ritual. Lastly, this presentation presents possible viable alternative healing modalities, such as spiritual healing, energy healing, and Shamanism, for women desiring to heal naturally from PCOS. Methodology and theoretical orientation: Our subject, Sara Jacobsen, was diagnosed with PCOS and infertility at age 29. Subject was given treatment of an herbal remedy which she consumed for one month. A month after diagnosis, subject met a Priestess of the fertility Goddess Oshun, and received a spiritual cleaning on her womb by said Priestess. Subject released emotional pain over childhood sexual abuse through spiritual healing work and rituals with the Goddess Oshun, as well as energy healing and Shamanism, over an 8 month period of time. Findings: Subject then went back to her doctor and underwent a trans-vaginal ultrasound again as well as a blood test again. Subject’s physical markers of having PCOS were gone. Conclusion and Significance: The significance of this case study is threefold. 1. To establish the connection between experiencing childhood abuse and later developing PCOS or other gynecological disorders 2. To educate the practitioners in attendance on this phenomenon so they can better educate their patients and 3. To inform practitioners in attendance of possible techniques for patients to naturally heal from PCOS including practicing spiritual healing, energy healing, mindfulness techniques and Shamanism.
Biography Sara Jacobsen is a Natural Fertility Guide, International Board Certified Lactation Consultant, Prenatal and Post-Partum Massage Therapist, Birth and Post-Partum Doula and Energy Healer. Sara has attended home births in East Oakland, California, helped HIV positive mothers breastfeed in South Africa, lectured on C Section Scar Massage at a mother-baby resource center, educated student doulas about the importance of natural fertility, and everything in between. Sara now supports women healing naturally from infertility, PCOS and Endometriosis through her business, Conceive With Joy.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 25 conferenceseries.com Khushbu Agrawal, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
OHSS in IVF treated patient with twin pregnancy complicated with Ovarian Torsion – A Case Presentation Khushbu Agrawal PGIMER, India
Summary: A 29 yrs lady with previous history of spontaneous abortion underwent IVF due to male factor infertility. Twins pregnancy after IVF developed OHSS afterth 8 day of Embryo transfer. Managed conservatively with B/L Pleurocentesis developed large cysts in both the ovaries at 13th weeks of pregnancy. Ultrasound diagnosed Torsion of left ovary. The patient underwent laparotomy with intraoperative finding of torsion on left ovary with clear cyst. B/L ovarian cystectomy was done and ovarian reconstruction done. Patient had fetal demise of one twin and the pregnancy continued as singleton pregnancy.
Biography Khushbu Agrawal has completed her MD Postgraduate in Postgraduate Institute of Medical Education and Research (PGIMER), India. During her thesis course, she has conducted this study after seeing the tedious course of therapy, the patient had to go in the institute infertility clinic. With dedication and a hope of having some significant results with reference from the literature, she has performed this study. Currently, she is working in private hospital practicing Obstetrics and Gynecology.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 26 conferenceseries.com 1482nd Conference
PCOS 2017
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Workshop Day 2
Page 32 conferenceseries.com Marjorie E Dixon, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Marjorie E Dixon Anova Fertility and Reproductive Health, Canada
A critical appraisal of PCOS diagnosis and management hat does Polycystic Ovary Syndrome (PCOS) mean for women today? This disorder affects 10-15% of women between Wthe ages of 14 to 44. The luteinizing hormone (LH) and insulin resistance are the most common endocrine aberrations seen in PCOS. Symptoms include irregular or absent period cycles, excess body and facial hair, diabetes, excessive acne, pelvic pain due to cyst, obesity and challenges with pregnancy. However, this shouldn’t deter women from their dream of having children, because it is still possible. During this session, we will examine: the implications of PCOS on health and fertility level; pathophysiology of PCOS and the incidence of PCOS in women who are of reproductive age; current fertility treatments and options available to assist women who are diagnosed with PCOS on getting pregnant: metformin, clomid, Intrauterine Insemination (IUI) and In Vitro Fertilization (IVF); the advantages and disadvantages of birth control on the female reproductive system; diagnostic criteria and assessment of PCOS for better outcomes and how to best prepare a woman with PCOS diagnosis for conception? Our goal is to help you better educate the women in your care with PCOS about their bodies and their options, and to provide those women with realistic hope when it comes to starting and/or growing their families.
Biography Marjorie E Dixon is a graduate of McGill University’s School of Medicine. Following her initial Postgraduate training at the University of Toronto in Obstetrics and Gynecology, she has completed her Postgraduate training at the University of Vermont. Through the American Board of Obstetrics and Gynecology, she achieved her specialty in Reproductive Endocrinology and Infertility. She is an Advocate for women’s health and speaks about fertility nationally and internationally. In 2016, she founded Anova Fertility and Reproductive Health in Toronto, Canada, a world-class centre focused on being the leader in innovation, education and communi- cation for quality, evidence-based, humanized fertility and reproductive care.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 33 conferenceseries.com 1482nd Conference
PCOS 2017
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Scientific Sessions & Abstracts Day 2
Page 34 conferenceseries.com Sonya Patel, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Traditional Chinese medicine treatment options in Indian women with polycystic ovary syndrome Sonya Patel Mirvana Acupuncture and Chinese Herbs, USA
Statement of the Problem: Research on polycystic ovary syndrome (PCOS) in Indian women has started to emerge recently. In western medicine, the same standard of care is applied to this demographic. However, the results are variable and may not offer an effective solution. Unlike other cultures, addressing the Indian diet and phenotypes may be the key to treating this population. Symptoms such as insulin resistance, acanthosis nigricans, hirsutism, infertility, irregular menstruation, and higher testosterone are several symptoms that may manifest in PCOS. It is possible that not these patients that present with the symptoms will be diagnosed with PCOS after routine examination. Some patients may have symptoms but have normal ovulation and ovarian health. Purpose: The purpose of this study is to provide traditional Chinese medicine (TCM) options for PCOS treatment. Eastern medicine considers culture and phenotypes when treating patients which may offer a solution for Indian PCOS patients. TCM can offer treatments which can help to prevent and treat hormonal imbalance in Indian PCOS patients leading to better overall health outcomes. In addition, the TCM view can also better define prevention and early intervention measures which can be taken. TCM methods can also be applied to those with PCOS symptoms but do not have the diagnosis. Methodology & Theoretical Orientation: By analyzing the Indian population diet, lifestyle, and gene-culture coevolution, a trend was discovered. Based upon the emerging commonality of Indian women, a universal TCM diagnosis could be adapted. Though each patient is an individual and TCM diagnosis is based upon this individuality, the common gene that runs through most Indian women is derived. Findings: The common TCM diagnosis for PCOS in Indian women is spleen deficiency and kidney yang deficiency. TCM protocols account for acupuncture treatments, herbal therapy, and diet. These factors are addressed within this paper which may help both eastern and western medicine doctors to better understand and formulate optimal protocols to treat PCOS in this population.
Biography Sonya Patel has been a licensed Acupuncturist for 15 years in the United States. She is a fellow of the American Board of Oriental Reproductive Medicine, and has been published in medical journals with leading doctors from MD Anderson Cancer Hospital, Baylor College of Medicine, Memorial Hermann, and Michael E DeBakey Veterans Hospital. She is currently pursuing a Doctorate in Acupuncture and Oriental Medicine (DAOM) at the California Institute of Integral Studies. With this additional degree, she hopes to be a better practitioner, and continue to conduct research, and support humanitarian causes. She has written articles, co-authored a book, and contributed to newspapers and magazines, along with being featured on radio shows.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 36 conferenceseries.com Marion Eckert-Krause, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Hooded disease–PCOS: Lifestyle-change with DEBEC-System: First step of health risk reduction Marion Eckert-Krause Fachinstitut für Stoffwechsel und Gesundheit, Austria
Background: Obesity, irregular menstruation, fertility issues, and hair/skin problems as main-factors for PCOS, don´t reflect every symptom of PCOS. Insulin resistance, hyper-cholesterolemia and reduced metabolism lead to far-reaching implications as increased risks of e.g. diabetes, cardiovascular disease, Hashimoto and endometrial cancer. Throughout a woman’s life, PCOS is present, actual without curing. This endocrine-metabolic disorder is multifarious, the root cause yet unknown. Therefore, a defined therapy after early diagnosis is important. Method: Pilot-Case Study, DEBEC-Systematic (Diagnostics-Eating-Balance-Exercise-Coaching) steering physical activity, dietary- change, holistic coaching. Period: 24 months, Endpoint: 15 kg weight-reduction and lifestyle-adaption. Measuring: weight (kg) and girth of waist (cm), hip (cm), neck (cm), BMI, body fat (in %), waist-hip ratio (WHR). Blood test: hormonal status, choles-terol, triglyceride, fasten glucose. Review after 36, 48, 60 months to emblaze sustainability of DEBEC-Method. Results: After 24 month’s therapies: weight reduction 17.1 kg (11 kg within 12 months). Blood test: normal hormonal status (under birth control pill), normal blood sugar level but cholesterol and triglyceride are out of specification (OOS). Contraceptive: Try and Error with Midane, Yasmin, Yaz, Cerazette related to side-effects. Personal: motivated, full of energy, success within her studies. Psychological: learned accepting living with PCOS. Review after 36, 48, 60 months cho-lesterol was still OOS and weight was 61±2 kg (BMI 22.8±1.5). Conclusion: This Pilot Study shows how an individual based therapy with defined mod-ules (DEBEC) can be successful related to health risk reduction suitable for daily use. Fat metabolism was not affected and must be further under control. Because of training about nutrition and exercise, the patient is en-abled for own health management (e.g. weight control in a 2-kg weight scope round BMI 23). Coaching is important for the pa-tient to preserve over a long time-period. Broader evidence based long-term studies are needed to fulfill individual requirements of PCOS-Patients with the DEBEC-Method.
Biography Marion Eckert-Krause is a specialist for metabolic diseases. After training as a Practice Nurse and Garden-er, she has studied Biology and Waste Management, and then she has worked for several years in field of sales before moving to internal sales via key account management. She spent nearly ten years in sales op-erations before earning a Doctorate in Medicine. Since then, she has worked in quality management and began with PCOS research. She has developed the DEBEC-Method and ran several case studies with menopausal/postmenopausal women including PCOS-diagnosed patients. To understand the principle of hair removal, she learnt electrolysis. Since 2012, she is actively joining congresses in Switzerland, Germany and Austria. Her Institute “FISGES” was founded in 2014 to take care of the PCOS-Patients needs with focus on a defined study. Since 2017, she is a Lecturer for Private University of Principality of Liechten-stein (UFL).
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 37 conferenceseries.com Khushbu Agrawal, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Polycystic ovarian syndrome and infertility: A randomize control trial for clomiphene citrate stair-step protocol Khushbu Agrawal PGIMER, India
Statement of the Problem: Infertility in women with Polycystic Ovarian Syndrome (PCOS) is a matter of concern in reproductive medicine. Ovulation Induction with Clomiphene Citrate (CC) is a first line treatment given in different doses. Researchers have reported that escalating the dose of CC in the same cycle after knowing the follicle size (also called stair-step protocol) is more effective than increasing it in the subsequent cycle (also called traditional protocol). However, the literature is sparse, and this study purpose is to bring light to a different and better method of using CC. Methodology & Theoretical Orientation: A Randomized Control Trial was done in women receiving CC for OI as a stair-step protocol (SSP) in the study group the dose of CC was increased gradually from 50 mg to 150 mg when the follicle size was insufficient to look for ovulation and later pregnancy. The study group was compared to control group where the dose was increased in next cycle after every failure of the previous dose. Findings: The women in study group using SSP has higher ovulation rate and pregnancy rate. The duration of treatment was significantly shorter in study group. The dose of 100 mg was the most effective dose for OI in either group. Conclusion & Significance: By using SSP, effective treatment is provided in significantly shorter time in without any detrimental effect on ovulation and pregnancy rates Women with PCOS and Infertility are benefitted using SSP.
Biography Khushbu Agrawal has completed her MD Postgraduate in Postgraduate Institute of Medical Education and Research (PGIMER), India. During her thesis course, she has conducted this study after seeing the tedious course of therapy, the patient had to go in the institute infertility clinic. With dedication and a hope of having some significant results with reference from the literature, she has performed this study. Currently, she is working in private hospital practicing Obstetrics and Gynecology.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 38 conferenceseries.com Felice Gersh, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Beyond pain pills and antidepressants: The nutritional approach to pain and mood issues for women with PCOS Felice Gersh Integrative Medical Group of Irvine, USA
omen with PCOS generally have more emotional suffering and physical pain than does the average woman. They have more Wanxiety and depression, more arthritis and tendinitis, more headaches, and more irritable bowel syndrome. This presentation will discuss the issues of pain and mood disorder in women with PCOS, and how they are closely linked and are greatly related to both the nutritional status and the endemic inflammation of the gut in women with PCOS. The evolving world of "nutritional psychiatry" recognizes that the brain is intricately linked to gut health, and that gut inflammation, and the resultant impaired gut barrier (leaky gut), result in systemic endotoxemia and consequently more mood disorders and hypersensitivity to pain stimuli. Women with PCOS are greatly impacted by various pain syndromes and anxiety. Women generally have heightened pain sensitivity and develop significantly more mood disorders than do men, which relates to the role of estrogen in both gut and brain wellbeing. Women with PCOS generally are more inflamed and have more gut dysbiosis. My presentation will bring all bodily systems together into a clear and cohesive focus, centered upon hormonal balance and the detection of nutritional deficiencies and gut dysbiosis, factors which lie at the center of mood disorders and chronic pain for women with PCOS.
Biography Felice Gersh is a Board Certified in both OB/GYN and in the new specialty of Integrative Medicine. She has graduated from the prestigious Fellowship in Integrative Medi- cine at the University of Arizona School of Medicine, received her Undergraduate degree from Princeton University, and her Medical degree from the USC School of Medi- cine. She has graduated as the top female student and was invited to join Alpha Omega Alpha, the elite medical honor society, open only to the top 5% of medical student graduates. She subsequently taught for over a dozen years as a Clinical Assistant Professor of OB/GYN at the Keck USC School of Medicine, has been the recipient of numerous awards, is a renowned national and international Lecturer, a Researcher, the author of book chapters and articles on women's health, has been featured on many web summits, webinars, and podcasts, and is currently writing a book on PCOS. She serves on several medical advisory boards, for medical industry and for non-profits, and is a sought-after forensic medical expert. She works alongside her team of lifestyle and holistic practitioners at the Integrative Medical Group of Irvine, where she is the Medical Director.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 39 conferenceseries.com 1482nd Conference
PCOS 2017
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Scientific Sessions & Abstracts Day 3
Page 40 conferenceseries.com Keshena Patterson, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
I have PCOS too, but it doesnt define me or you! Keshena Patterson Author and Advocate, Houston Texas USA, USA
ral Synopsis: I am Keshena Patterson and I’ve been through the emotional journey of PCOS(polycystic ovarian syndrome). OLiving trapped in a body with your hormones out of whack is an experience that I would never wish on anybody, but it taught me something important too: To keep my head up, to stay positive, and to stay spiritual as I surpass my goals and turned my life around more than I ever thought could be possible. My talk will consist of when I was diagnosed, all of the symptoms I faced and still do. The many dark years I experienced letting the condition take over my life. I will also speak about when I decided to turn it around, take better care of myself, learn self awareness and change the things I could. The decisions I made changed my life a great deal and I will encourage the audience to do the same. I will also do a crowd participation activity that will allow everyone to focus on something about themselves they enjoy and keep it at the center of their day to help them stay focused and positive! Biography Keshena has a Bachelors Science in Radiology Technology. She has worked as a Radiology Technologist for over 7 years. She has experience in a variety of positions including a leadership role. She now works as a Clinical Education Specialist for Siemens Healthineers. She is also a respected independent author publishing a part memoir, part informational non fiction book about her journey with PCOS(polycystic ovarian syndrome) called “I Kept My Smile, From A Girl To A Woman With: PCOS”. Her passion is self-love, patient care, raising awareness for PCOS, and to support and encourage women and young girls with PCOS to be fearless and take control. She is also a motivational speaker and has written publications in her career field and the PCOS community.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 42 conferenceseries.com Michelle Cooke, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
N-acetylcysteine: A multi-dimensional approach for the treatment of PCOS Michelle Cooke Reproductive Wellness, Australia
olycystic ovarian syndrome (PCOS) has been previously considered to be primarily a gynecological health issue with a reproductive Pendocrinology presentation of imbalanced sex hormones. However, further research has highlighted the multifaceted nature of PCOS involving several endocrine releasing glands beyond the realm of the hypothalamic-pituitary-ovarian axis. The endocrine releasing glands potentially involved as part of this multi-glandular syndrome are the thyroid, hypothalamus, pituitary, adrenals (hypothalamic-pituitary-adrenal axis) and the pancreas. Apart from these glands, the liver is often impacted in those with PCOS. Abnormal lipoprotein profile can be found, typically including low high-density lipoproteins (HDL), elevated low-density lipoproteins (LDL), elevated triglycerides, elevated total cholesterol and low apoprotein A-12. The prevalence of non-alcoholic fatty liver disease (NAFLD) is considerable in conditions correlated with insulin resistance (IR) which is a common feature of PCOS. It is speculated that NAFLD is a hepatic indicator of metabolic syndrome. Metabolic syndrome and IR are both an increasingly common finding in a PCOS presentation. Considering the multi-dimensional nature of PCOS; a treatment protocol needs to address all factors to successfully treat and manage this complex syndrome. N-acetylcysteine (NAC) is just one of many nutritional medicines that is considered an effective adjunctive therapy for the treatment of PCOS. NAC is a sulfur containing derivative from the amino acid L-cysteine and is a precursor to glutathione. This lecture will uncover the diverse actions of NAC, beyond that of purely correcting sex hormone imbalance in women suffering with PCOS. Biography Michelle Cooke is an experienced Naturopath specializing in fertility, preconception, pregnancy, ART support, post-natal health and reproductive endocrinology. She offers a holistic treatment approach encompassing various complementary and alternative medicine (CAM): nutritional medicine, western herbal medicine and homoeopathy in conjunction with dietary and lifestyle advice. She has 17 years’ experience within the health industry. She has completed her Bachelor of Health Science (Complementary Medicine) at Charles Sturt University in 2010 and the Advanced Diploma of Naturopathy at Nature Care College in 2006. She is the Founder and the Director of Reproduc- tive Wellness, a naturopathic practice specialising in reproductive endocrinology located in Melbourne, Australia.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 43 conferenceseries.com Paul Stanciu, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Does PCOS increase the risk of developing endometrial cancer? Paul Stanciu Oncology Center of North London, UK
olycystic Ovarian Syndrome is an endocrine disorder encountered in 4-18% of all women at reproductive age. On the other Pside, endometrial cancer is one of the most common gynecological cancers in developed countries. About 25% of women with EC are pre-menopausal and 5% of all cases are diagnosed at ages younger than 40 years. In 1949, Speert was the first to suggest the association between PCOS and EC. Women with PCOS present several risk factors for EC: unopposed estrogen exposure of the endometrium increases the risk for endometrial hyperplasia and cancer, but there is also obesity, insulin resistance, diabetes, nulliparity, and progesterone resistance. Until the end of the last century several studies that support this association were published. Most of this studies lack control groups and the number of the subjects was too small. One recent study from UK shows an increased endometrial expression of genes involved in insulin signaling pathway (IGF1, IGFBP1 and PTEN) for women with PCOS and EC. Also, Cyclin D1 expression was shown to be significantly increased in the endometrial cancers associated with PCOS. Recent meta- analysis show women with PCOS are three times more likely to develop EC. This translates into a lifetime risk of 9% for developing EC compared with only 3% in the general population. Danish Cohort Study published in 2015 found an almost fourfold increased risk for endometrial cancer. Considering that, early endometrial cancer detection and treatment are associated with more than 86% survival rate at 5 years, this association calls for implementation of risk-reducing measures and sustained screening programs. Biography Paul Stanciu has completed his residency training in Obstetrics and Gynecology in Romania. He obtained his PhD from Victor Babes University of Medicine and Pharmacy from Timisoara, Romania. He did an Oncological Gynecology Fellowship with St. James’s Hospital in Dublin, Ireland and now he is fellow with one of the busiest Oncology Center of North London area at Watford. He has published several papers regarding minimally invasive techniques used to treat gynecological malignancies and has a great interest in fertility sparing surgery for oncologic patients.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
Page 44 conferenceseries.com Erika Toth, Endocrinol Metab Syndr 2017, 6:6 (Suppl) DOI: 10.4172/2161-1017-C1-020
3rd World Congress on Polycystic Ovarian Syndrome November 15-17, 2017 | San Antonio, USA
Depression, anxiety and satisfaction with life in patients with polycystic ovary syndrome Erika Toth MSc, MA, University of Szeged, Hungary
ue to the nature of the condition, PCOS patients suffer both from primary and secondary psychological consequences. DThe primary psychological consequences stem from the hormonal imbalance, while the secondary psychological consequences follow the emotional burden patients face. Despite this phenomenon, medical treatment of PCOS often only focuses on the physiological sypmtoms, and psychological problems remain untreated. Psychological problems however often impact the physiological symptoms, thus worsening the condition. A recent study conducted at our university aimed to explore this multidimensional syndrome, and its relation with depression, anxiety, satisfaction with life, self-efficacy and certain demographic variables. Analyzing data of women with and without PCOS, significant difference was observed in their values of depression and satisfaction with life. No significant difference was found related to their values of anxiety, self-efficacy and their demographic values. The result of the research project suggests that screening and prevention of depression should be part of PCOS treatment, and patients need accurate information about the long-term risks associated with this condition in order to achieve a sustainable lifestyle change. Biography Erika Toth is a clinical and health psychologist, focusing on health psychology in the area of obstetrics & gynecology.
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Endocrinol Metab Syndr, an open access journal PCOS 2017 Volume 6, Issue 6 (Suppl) ISSN: 2161-1017 November 15-17, 2017
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