Thrombopoietin Receptor Agonist Eltrombopag Prevents Insulin Resistance and Synaptic Pathology via HIF1α/COX2/Sirt1 Signaling Pathway he yu Wenzhou Medical University First Aliated Hospital: The First Aliated Hospital of Wenzhou Medical University xuebao wang Wenzhou Medical College First Aliated Hospital: The First Aliated Hospital of Wenzhou Medical University leping liu Wenzhou Medical College First Aliated Hospital: The First Aliated Hospital of Wenzhou Medical University baihui chen Wenzhou Medical College First Aliated Hospital: The First Aliated Hospital of Wenzhou Medical University shuya feng Wenzhou Medical College First Aliated Hospital: The First Aliated Hospital of Wenzhou Medical University xiaoai lu Wenzhou Medical University First Aliated Hospital: The First Aliated Hospital of Wenzhou Medical University ruimin you Wenzhou Medical University First Aliated Hospital: The First Aliated Hospital of Wenzhou Medical University Saidan Ding (
[email protected] ) Wenzhou Medical University First Aliated Hospital Research Keywords: cognitive impairment, synapse, Thrombopoietin, eltrombopag, insulin resistance Posted Date: March 19th, 2021 DOI: https://doi.org/10.21203/rs.3.rs-308317/v1 Page 1/30 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 2/30 Abstract Background: Insulin resistance has been reported to be closely correlated with the pathogenesis of MHE. The mechanism underlying the effects of thrombopoietin receptor agonist eltrombopag (ELT) on synaptic