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Electronic Supplementary Material (ESI) for Analytical Methods. This journal is © The Royal Society of Chemistry 2021 Supplemental Table 1. List of substances with corresponding elemental composition, exact mass, retention time (RT), minimum screening sensitivity, extraction recovery and the shifts of mass and retention time from three-day validation analysis. Minimum [M+H]+ Mass RT RT Elemental Screening Extraction Substances Exact Shift shift Composition Sensitivity Recovery mass (ppm) (min) (s) (ng/mL) 1,3-Benzodioxolyl-N-methylbutanamine C12H17NO2 208.1332 0.1 3.13 0.8 0.50 96.6% 15β-Hydroxytestosterone C19H28O3 305.2111 -1.1 3.50 -0.3 0.10 87.5% 16β-Hydroxytestoterone C19H28O3 305.2111 -1.1 3.97 0.1 0.25 94.8% 2-(1-Hydroxyethyl) promazine sulfoxide C19H24N2O2S 345.1631 -1.3 3.13 0.5 1.00 41.1% 2-(1-Hydroxypropyl)promazine sulfoxide C20H26N2O2S 359.1788 -1.1 3.35 0.9 2.00 38.5% 2-Aminoheptane C7H17N 116.1434 0.0 2.98 0.1 ND1 89.1% 2α-Hydroxymethylethisterone C22H30O3 343.2268 -1.8 4.35 -0.2 0.25 96.8% 3,4-Methylenedioxyamphetamine C10H13NO2 180.1019 0.1 2.78 0.0 0.50 73.8% 3,4-Methylenedioxypropylamphetamine C13H19NO2 222.1489 -0.9 3.14 0.3 0.10 113.1% 3-Hydroxymepivacaine C15H22N2O2 263.1754 -0.3 2.52 -0.6 0.20 89.2% 3-Hydroxypromazine C17H20N2OS 301.1369 -0.7 3.60 -2.0 0.10 77.9% 3-OH Lidocaine C14H22N2O2 251.1754 1.1 2.42 0.5 0.06 92.4% 4-Chloroamphetamine C9H12ClN 170.0731 0.1 3.27 0.2 ND 91.8% 4-Hydroxypropranolol C16H21NO3 276.1594 -0.7 3.17 2.7 0.20 83.7% 4-Methoxymethamphetamine C11H17NO 180.1383 -0.4 2.96 0.0 0.05 72.7% 5,6-Methylenedioxy-2-aminoindane C10H11NO2 178.0863 0.0 2.56 0.8 0.10 64.2% 6-Dehydroandrostenedione C19H24O2 285.1849 -1.0 4.53 0.8 0.10 96.0% 6-Dehydronandrolone C18H24O2 273.1849 -0.8 4.31 0.1 0.25 98.2% 6-Dehydrotestosterone C19H26O2 287.2006 -1.3 4.49 0.1 0.10 87.3% 7-Aminoclonazepam C15H12ClN3O 286.0742 -1.1 3.23 0.6 0.50 91.5% 7-Aminoflunitrazepam C16H14FN3O 284.1194 -1.2 3.46 0.3 0.10 92.3% 7-Hydroxy Fluphenazine C22H26F3N3O2S 454.1771 0.0 4.11 0.1 2.00 79.0% 7-Hydroxychlorpromazine C17H19ClN2OS 335.0979 -0.8 3.90 0.6 0.20 79.4% 9-Dehydroandrostenedione C19H24O2 285.1849 -1.1 4.68 -0.4 0.10 95.3% 9-Dehydromethyl-testosterone C20H28O2 301.2162 -1.3 4.72 -0.2 0.25 93.3% 9-Dehydrotestosterone C19H26O2 287.2006 -1.3 4.52 -1.7 0.10 87.3% A-796,260 C22H30N2O2 355.2380 -1.3 5.31 -1.6 0.10 87.1% AB Pinaca C18H26N4O2 331.2129 -0.5 4.97 -1.8 0.25 93.0% AB-Fubinaca C20H21FN4O2 369.1721 -1.1 4.65 -1.6 0.10 95.2% Acebutolol C18H28N2O4 337.2122 -1.6 3.15 1.2 0.25 46.7% Acetaminophen C8H9NO2 152.0706 -0.1 2.22 -0.8 1.00 67.1% Acetophenazine C23H29N3O2S 412.2053 -1.6 3.92 1.7 0.25 89.0% Adrenosterone C19H24O3 301.1798 -1.1 4.11 0.4 0.10 96.1% AH-7921 C16H22Cl2N2O 329.1182 -1.4 3.80 2.0 0.25 101.7% Albuterol C13H21NO3 240.1594 0.5 2.20 -0.7 1.00 7.0% Alfentanil C21H32N6O3 417.2609 -0.6 3.85 2.7 0.20 96.8% Alprazolam C17H13ClN4 309.0902 -0.5 4.43 1.8 0.25 90.7% Alprenolol C15H23NO2 250.1802 -0.9 3.66 0.2 0.10 92.1% Altrenogest C21H26O2 311.2006 -1.0 4.99 -0.2 0.10 90.6% AM 2233 C22H23IN2O 459.0928 -0.3 4.00 0.1 0.10 86.6% AM-2201 C24H22FNO 360.1758 -0.6 5.71 -2.8 0.10 107.5% AM-2201 Benzimidazole analog C23H21FN2O 361.1711 -0.6 5.89 -1.3 0.25 105.3% AM-2201 N-(4-hydroxypentyl) Metabolite C24H22FNO2 376.1707 -0.9 5.02 -2.4 0.10 88.0% AM-630 C23H25IN2O3 505.0983 0.1 5.38 -1.7 0.25 75.8% Ambroxol C13H18N2OBr2 376.9859 -1.5 3.26 0.4 ND 96.0% Amiloride C6H8ClN7O 230.0552 -0.8 2.11 -0.1 1.00 2.5% Aminopentamide C19H24N2O 297.1961 -0.6 3.66 0.0 0.10 86.8% Aminorex C9H10N2O 163.0866 -0.6 2.54 0.1 0.10 82.4% Amiphenazole (Diamino-5-phenylthiazole) C9H9N3S 192.0590 -0.4 2.33 0.5 1.00 94.5% Amoxapine C17H16ClN3O 314.1055 -1.0 4.00 1.7 0.25 96.1% Amphetamine C9H13N 136.1121 -0.1 2.76 0.2 NA 74.6% Anastrozole C17H19N5 294.1713 -1.1 4.08 -0.4 0.50 106.4% Androstatriendione C19H22O2 283.1693 -1.1 4.47 -0.1 0.50 93.5% Androstenedione C19H26O2 287.2006 -1.1 4.80 0.6 1.00 94.0% Antipyrine C11H12N2O 189.1022 0.3 3.05 -0.7 0.25 38.2% Apomorphine C17H17NO2 268.1332 -0.2 2.88 1.3 1.00 84.7% Aprindine C22H30N2 323.2482 -1.2 4.60 1.7 0.10 96.4% Aripiprazole C23H27Cl2N3O2 448.1553 -1.0 4.21 0.1 1.00 78.2% Asimilobine C17H17NO2 268.1332 0.0 3.11 0.4 0.10 99.0% Astemizole C28H31FN4O 459.2555 -1.3 3.94 0.1 1.00 81.2% Atenolol C14H22N2O3 267.1703 -1.1 0.82 0.1 ND 0.8% Atropine C17H23NO3 290.1751 -1.0 2.99 1.7 0.10 60.0% Azaperone C19H22FN3O 328.1820 -1.1 3.60 1.3 0.25 80.9% Azelastine C22H24ClN3O 382.1681 -1.6 4.15 0.6 0.25 95.2% Bambuterol C18H29N3O5 368.2180 -1.5 3.41 1.2 0.50 46.4% Benactyzine C20H25NO3 328.1907 -1.2 3.75 1.6 0.10 95.5% Benazepril C24H28N2O5 425.2071 -0.3 4.53 0.4 ND 2.6% Benzoylecgonine C16H19NO4 290.1387 -0.4 2.96 -1.4 20.0 0.3% Benzphetamine C17H21N 240.1747 -0.6 3.83 -0.7 0.05 109.9% Betaxolol C18H29NO3 308.2220 -1.3 3.75 1.4 0.10 96.3% Biperiden C21H29NO 312.2322 -1.3 4.15 1.7 0.25 90.6% Bisoprolol C18H31NO4 326.2326 -1.3 3.64 1.3 0.10 89.2% Bolasterone C21H32O2 317.2475 -1.9 4.95 0.3 0.10 89.0% Boldenone C19H26O2 287.2006 0.2 4.51 1.3 0.05 103.9% Boldenone Acetate C21H28O3 329.2111 -2.6 5.44 1.2 0.10 96.7% Boldine C19H21NO4 328.1543 -1.3 2.84 1.8 0.25 101.3% Boldione C19H24O2 285.1849 -1.0 4.53 0.6 0.10 96.0% Bromazepam C14H10BrN3O 316.0080 -1.1 3.99 1.6 0.25 94.0% Brombuterol C12H18Br2N2O 364.9859 -1.3 3.45 -1.0 ND 98.2% Bromhexine C14H20Br2N2 375.0066 -1.2 4.78 -1.0 ND 39.1% Bromocriptine C32H40BrN5O5 654.2286 -0.4 4.55 1.7 1.00 78.9% Brompheniramine C16H19BrN2 319.0804 -1.0 3.78 1.0 0.25 92.4% Brotizolam C15H10BrClN4S 392.9571 -1.4 4.58 1.3 ND 95.4% Budesonide C25H34O6 431.2428 -1.3 4.63 -0.4 1.00 104.4% Buflomedil C17H25NO4 308.1856 -1.1 3.36 0.9 0.10 87.2% Bumetanide C17H20N2O5S 365.1166 -1.7 4.58 0.4 20.0 5.5% Buphedrone C11H15NO 178.1226 -0.2 2.89 -0.3 0.05 122.3% Bupivacaine C18H28N2O 289.2274 -0.5 3.74 0.9 0.10 99.7% Buprenorphine C29H41NO4 468.3108 -0.4 4.06 1.0 ND 81.6% Bupropion C13H18ClNO 240.1150 -0.7 3.59 1.1 0.25 120.7% Buspirone C21H31N5O2 386.2551 -0.8 3.69 -2.0 0.20 97.6% Butorphanol C21H29NO2 328.2271 -0.1 3.54 -0.2 0.20 95.6% Butylone C12H15NO3 222.1125 -1.1 2.93 0.1 0.25 100.0% Caffeine C8H10N4O2 195.0877 0.3 2.72 -0.1 1.00 40.6% Calusterone C21H32O2 317.2475 -2.2 5.05 0.3 0.25 85.5% Canrenone C22H28O3 341.2111 -2.3 4.82 0.3 0.25 106.7% Capsaicin C18H27NO3 306.2064 -1.0 5.06 0.9 0.10 92.4% Carazolol C18H22N2O2 299.1754 -1.3 3.39 1.4 0.10 95.1% Carbamazepine C15H12N2O 237.1022 -0.9 4.14 0.6 0.10 93.0% Carbinoxamine C16H19ClN2O 291.1259 0.1 3.66 1.1 0.50 88.5% Carfentanil C24H30N2O3 395.2329 -0.5 4.08 -0.8 0.20 97.7% Carisoprodol C12H24N2O4 261.1809 -0.7 4.27 0.9 0.10 88.6% Carteolol C16H24N2O3 293.1860 -1.3 2.60 0.1 1.00 25.4% Carvedilol C24H26N2O4 407.1965 -1.7 4.04 0.7 0.25 92.0% Cathinone C9H11NO 150.0913 0.1 2.47 -1.1 ND 94.4% Celecoxib C17H14F3N3O2S 382.0832 -1.6 5.17 0.9 1.00 82.5% Celiprolol C20H33N3O4 380.2544 -1.3 3.41 0.8 0.25 30.4% Cetirizine C21H25ClN2O3 389.1627 -1.5 4.20 2.0 NA 2.7% Chlordiazepoxide C16H14ClN3O 300.0898 -0.8 4.22 1.0 0.10 98.6% Chlorprothixene C18H18ClNS 316.0921 -1.3 4.46 1.3 0.50 78.5% Chlorthalidone C14H11ClN2O4S 339.0201 -0.7 3.26 1.0 ND 77.5% Cimaterol C12H17N3O 220.1444 -2.7 2.17 -0.5 0.50 52.3% Cimetidine C10H16N6S 253.1230 -1.8 2.17 -1.9 ND 13.8% Cinnarizine C26H28N2 369.2325 -0.2 4.86 1.4 1.00 34.1% Cisapride C23H29ClFN3O4 466.1903 -1.1 3.98 0.5 0.25 93.7% Citalopram C20H21FN2O 325.1711 -1.1 3.90 1.5 1.00 97.7% Clenbuterol C12H18Cl2N2O 277.0869 0.3 3.30 0.4 0.04 94.6% Clobazam C16H13ClN2O2 301.0738 -1.1 4.65 1.0 0.25 98.9% Clomipramine C19H23ClN2 315.1623 -1.0 4.49 1.2 0.50 81.9% Clonazepam C15H10ClN3O3 316.0484 -1.1 4.36 0.7 1.00 94.8% Clonidine C9H9Cl2N3 230.0246 -1.1 2.63 1.8 0.25 94.8% Clopamide C14H20ClN3O3S 346.0987 -1.2 3.64 0.6 0.25 97.5% Clostebol C19H27ClO2 323.1772 -2.0 5.00 0.5 ND 95.9% Clozapine C18H19ClN4 327.1371 -1.2 3.88 1.2 ND 107.4% Cocaethylene C18H23NO4 318.1700 -1.1 3.67 1.2 0.10 98.1% Cocaine C17H21NO4 304.1543 -1.1 3.45 -0.3 0.10 98.1% Cotinine C10H12N2O 177.1022 0.0 2.02 0.0 0.10 10.4% Cyclobenzaprine C20H21N 276.1747 -0.3 4.20 1.3 0.25 91.3% Danazol C22H27NO2 338.2115 -1.8 5.37 0.6 0.10 76.9% Dembrexine C13H17Br2NO2 377.9699 -1.6 3.17 -0.1 ND 94.8% Deoxycorticosterone C21H30O3 331.2268 -1.1 4.65 -0.7 1.00 101.8% Deracoxib C17H14F3N3O3S 398.0781 -1.0 4.78 1.1 2.00 83.6% Desalkylflurazepam C15H10ClFN2O 289.0539 -0.2 4.55 0.5 1.00 100.5% Deserpidine C32H38N2O8 579.2701 -0.1 4.41 0.9 1.00 82.1% Desipramine C18H22N2 267.1856 -0.3 4.17 -0.1 0.20 91.2% Desmethylmetoprolol C14H23NO3 254.1751 -1.0 2.66 -0.4 2.00 27.0% Desonide C24H32O6 417.2272 -1.5 4.17 0.0 0.10 97.6% Desoximetasone C22H29O4F 377.2123 -1.7 4.30 -0.2 0.25 105.1% Despropionylfentanyl C19H24N2 281.2012 0.7 3.91 1.8 0.10 95.1% Detomidine C12H14N2 187.1230 1.1 3.42 0.4 0.20 91.2% Dexamethasone C22H29FO5 393.2072 -0.1 4.18 1.0 ND 90.5% Dextromethorphan C18H25NO 272.2009 -0.8 3.74 -2.3 0.10 98.0% Dextrorphan C17H23NO 258.1852 -0.5 3.14 0.6 0.10 100.3% Dezocine C16H23NO 246.1852 -0.3 3.21 0.4 0.20 98.7% Dibucaine C20H29N3O2 344.2333 -1.0 4.34 0.4 0.25 92.4% Dichlorisone acetate C23H28Cl2O5 455.1387 -1.0 4.97 0.6 1.00 98.0% Diclofenac C14H11Cl2NO2 296.0240 0.1 5.16 0.2 ND 26.0% Dicyclomine C19H35NO2 310.2741 -0.8 4.88 1.2 0.25 66.5% Diethylpropion C13H19NO 206.1539 -0.4 2.95 0.0 ND 139.4% Dihydrocapsaicin C18H29NO3 308.2220 -1.2 5.17 0.3 0.10 81.2% Dihydrocodeine C18H23NO3 302.1751 -1.2 2.55 0.1 0.10 71.1% Dihydromorphine C17H21NO3 288.1594 -1.0 1.40 -0.1 0.25 30.7% Diphenhydramine C17H21NO 256.1696 -0.9 3.77 0.7 0.10 104.9% Dobutamine C18H23NO3 302.1751 -1.1 2.96 0.8
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    US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist.
  • Customs Tariff - Schedule

    Customs Tariff - Schedule

    CUSTOMS TARIFF - SCHEDULE 99 - i Chapter 99 SPECIAL CLASSIFICATION PROVISIONS - COMMERCIAL Notes. 1. The provisions of this Chapter are not subject to the rule of specificity in General Interpretative Rule 3 (a). 2. Goods which may be classified under the provisions of Chapter 99, if also eligible for classification under the provisions of Chapter 98, shall be classified in Chapter 98. 3. Goods may be classified under a tariff item in this Chapter and be entitled to the Most-Favoured-Nation Tariff or a preferential tariff rate of customs duty under this Chapter that applies to those goods according to the tariff treatment applicable to their country of origin only after classification under a tariff item in Chapters 1 to 97 has been determined and the conditions of any Chapter 99 provision and any applicable regulations or orders in relation thereto have been met. 4. The words and expressions used in this Chapter have the same meaning as in Chapters 1 to 97. Issued January 1, 2020 99 - 1 CUSTOMS TARIFF - SCHEDULE Tariff Unit of MFN Applicable SS Description of Goods Item Meas. Tariff Preferential Tariffs 9901.00.00 Articles and materials for use in the manufacture or repair of the Free CCCT, LDCT, GPT, UST, following to be employed in commercial fishing or the commercial MT, MUST, CIAT, CT, harvesting of marine plants: CRT, IT, NT, SLT, PT, COLT, JT, PAT, HNT, Artificial bait; KRT, CEUT, UAT, CPTPT: Free Carapace measures; Cordage, fishing lines (including marlines), rope and twine, of a circumference not exceeding 38 mm; Devices for keeping nets open; Fish hooks; Fishing nets and netting; Jiggers; Line floats; Lobster traps; Lures; Marker buoys of any material excluding wood; Net floats; Scallop drag nets; Spat collectors and collector holders; Swivels.
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE

    )&F1y3x PHARMACEUTICAL APPENDIX to THE

    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
  • NINDS Custom Collection II

    NINDS Custom Collection II

    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
  • Determination of 17 Hormone Residues in Milk by Ultra-High-Performance Liquid Chromatography and Triple Quadrupole Mass Spectrom

    Determination of 17 Hormone Residues in Milk by Ultra-High-Performance Liquid Chromatography and Triple Quadrupole Mass Spectrom

    No. LCMSMS-065E Liquid Chromatography Mass Spectrometry Determination of 17 Hormone Residues in Milk by Ultra-High-Performance Liquid Chromatography and Triple Quadrupole No. LCMSMS-65E Mass Spectrometry This application news presents a method for the determination of 17 hormone residues in milk using Shimadzu Ultra-High-Performance Liquid Chromatograph (UHPLC) LC-30A and Triple Quadrupole Mass Spectrometer LCMS- 8040. After sample pretreatment, the compounds in the milk matrix were separated using UPLC LC-30A and analyzed via Triple Quadrupole Mass Spectrometer LCMS-8040. All 17 hormones displayed good linearity within their respective concentration range, with correlation coefficient in the range of 0.9974 and 0.9999. The RSD% of retention time and peak area of 17 hormones at the low-, mid- and high- concentrations were in the range of 0.0102-0.161% and 0.563-6.55% respectively, indicating good instrument precision. Method validation was conducted and the matrix spike recovery of milk ranged between 61.00-110.9%. The limit of quantitation was 0.14-0.975 g/kg, and it meets the requirement for detection of hormones in milk. Keywords: Hormones; Milk; Solid phase extraction; Ultra performance liquid chromatograph; Triple quadrupole mass spectrometry ■ Introduction Since 2008’s melamine-tainted milk scandal, the With reference to China’s national standard GB/T adulteration of milk powder has become a major 21981-2008 "Hormone Multi-Residue Detection food safety concern. In recent years, another case of Method for Animal-derived Food - LC-MS Method", dairy product safety is suspected to cause "infant a method utilizing solid phase extraction, ultra- sexual precocity" (also known as precocious puberty) performance liquid chromatography and triple and has become another major issue challenging the quadrupole mass spectrometry was developed for dairy industry in China.
  • Part I Biopharmaceuticals

    Part I Biopharmaceuticals

    1 Part I Biopharmaceuticals Translational Medicine: Molecular Pharmacology and Drug Discovery First Edition. Edited by Robert A. Meyers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 3 1 Analogs and Antagonists of Male Sex Hormones Robert W. Brueggemeier The Ohio State University, Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Columbus, Ohio 43210, USA 1Introduction6 2 Historical 6 3 Endogenous Male Sex Hormones 7 3.1 Occurrence and Physiological Roles 7 3.2 Biosynthesis 8 3.3 Absorption and Distribution 12 3.4 Metabolism 13 3.4.1 Reductive Metabolism 14 3.4.2 Oxidative Metabolism 17 3.5 Mechanism of Action 19 4 Synthetic Androgens 24 4.1 Current Drugs on the Market 24 4.2 Therapeutic Uses and Bioassays 25 4.3 Structure–Activity Relationships for Steroidal Androgens 26 4.3.1 Early Modifications 26 4.3.2 Methylated Derivatives 26 4.3.3 Ester Derivatives 27 4.3.4 Halo Derivatives 27 4.3.5 Other Androgen Derivatives 28 4.3.6 Summary of Structure–Activity Relationships of Steroidal Androgens 28 4.4 Nonsteroidal Androgens, Selective Androgen Receptor Modulators (SARMs) 30 4.5 Absorption, Distribution, and Metabolism 31 4.6 Toxicities 32 Translational Medicine: Molecular Pharmacology and Drug Discovery First Edition. Edited by Robert A. Meyers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 4 Analogs and Antagonists of Male Sex Hormones 5 Anabolic Agents 32 5.1 Current Drugs on the Market 32 5.2 Therapeutic Uses and Bioassays
  • A10 Anabolic Steroids Hardcore Info

    A10 Anabolic Steroids Hardcore Info

    CONTENTS GENERAL INFORMATION 3 Anabolic steroids – What are they? 4 How do they Work? – Aromatisation 5 More molecules – More problems 6 The side effects of anabolic steroids 7 Women and anabolic steroids 8 Injecting steroids 9 Abscesses – Needle Exchanges 10 Intramuscular injection 11 Injection sites 12 Oral steroids – Cycles – Stacking 13 Diet 14 Where do steroids come from? Spotting a counterfeit 15 Drug Information – Drug dosage STEROIDS 16 Anadrol – Andriol 17 Anavar – Deca-Durabolin 18 Dynabolon – Durabolin – Dianabol 19 Esiclene – Equipoise 20 Primobolan Depot – Proviron – Primobolan orals – Pronobol 21 Sustanon – Stromba, Strombaject – Testosterone Cypionate Testosterone Enanthate 22 Testosterone Propionate – Testosterone Suspension 23 Trenbolone Acetate – Winstrol OTHER DRUGS 24 Aldactone – Arimidex 25 Clenbuterol – Cytomel 26 Ephedrine Hydrochloride – GHB 27 Growth Hormone 28 Insulin 30 Insulin-Like Growth Factor-1 – Human Chorionic Gonadotrophin 31 Tamoxifen – Nubain – Recreational Drugs 32 Steroids and the Law 34 Glossary ANABOLIC STEROIDS People use anabolic steroids for various reasons, some use them to build muscle for their job, others just want to look good and some use them to help them in sport or body building. Whatever the reason, care needs to be taken so that as little harm is done to the body as possible because despite having muscle building effects they also have serious side effects especially when used incorrectly. WHAT ARE THEY? Anabolic steroids are man made versions of the hormone testosterone. Testosterone is the chemical in men responsible for facial hair, deepening of the voice and sex organ development, basically the masculine things Steroids are in a man. used in medicine to treat anaemia, muscle weakness after These masculine effects surgery etc, vascular are called the androgenic disorders and effects of testosterone.