CENTRE FOR IMMUNE REGULATION (CIR) 56 FINAL REPORT 2007–2017 57

Rajesh Grover, The Scripps Oliver Pabst, Hannover Medical Guest lecturer Research Institute, California, US School, Germany A Battle for Survival: Dynamics of the IgA response SEMINAR Chronic Bacterial Infections – Unexpected Consequences Roberta Pelanda, 1DWLRQDO-HZLVK “Transition from program Health and University of Colorado and B Cell Lymphoma and academia to industry” Myeloma – Bacterial Origins? Denver School of Medicine, US The guest lecturer program has been organised by a post- Click your heels: you are The postdoc committee Marc K. Jenkins, University in the land of B cells has also arranged a semi- doc committee with representatives from all the research of Minnesota, US Shimon Sakaguchi, Osaka nar with national speakers JURXSVDW&,57KHFRPPLWWHHKDVLQYLWHGKLJKUDQNHGLQWHU - The CD4+ T cell response to bacterial infection 8QLYHUVLW\-DSDQ who have either performed national researchers to come to Oslo to stay with our centre Molecular basis of regulatory a successful transfer from one or two days to interact with researchers at the centre and Steffen Jung, Weizmann T cell development and their academia to industry or are Institute of Science, Israel JLYHDSXEOLFJXHVWOHFWXUH7KHUHVXOWLVDORQJYLVLWRUOLVWRI functional stability involved in the transition thirty researchers from excellent research institutions all over Macrophages – development process. & tissue specialisation Bernd Schröder, Christian-Albrechts- WKHZRUOG7KHLUNQRZOHGJHDQGH[SHUWLVHKDVFRQWULEXWHG University of Kiel, Germany Øystein Rekdal, CSO, strongly to shape the research at CIR, and several collabora- Ludger Klein, Ludwig Maximilians SPPL intramembrane proteases Universität München, Germany – How they control immune cell Lytix Biopharma, Oslo tive projects and researcher exchange have been initiated as Shaping of the CD4 T cell development and function From bench to bedside DUHVXOWRIWKHVHYLVLWV repertoire by a self- of the central nervous system Michael Sieweke, Centre d'Immuno- oncolytic peptide logie de Marseille-Luminy, France Thomas Seth Kupper, Harvard Beyond stem cells : Marophage Geir Åge Løset, CSO, Medical School, US self renewal and identity Nextera, Oslo T cell memory: new insights Basic research and Caetano Reis e Sousa, industrial translation Committee members 2007–2017 Ralf Küppers, University of The Francis Crick Institute, UK – the ultimate blend Duisburg-Essen, Germany A DaNGeRous talk Agnete Fredriksen, CSO, -DQ7HUMH$QGHUVHQ • Espen Bækkevold • Sudhir Kuman Chauhan • Elena Danilova • Roberto DiNiro • Even Generation and function of about dendritic cells Vaccibody, Oslo Fossum • Dominik Michael Frei • Ramakrishna Gopalakrishnan •7RQH)*UHJHUV •/LVD0*UXEHU •.ULVWLQ6 human memory B cells and Sarah Teichmann, EMBL From PhD to CSO in Clinical Gunnarsen • Peter Huszthy • • • • Nadia Mensali aspects of CLL pathogenesis -RKDQQH7-DFREVHQ 2OH-%/DQGVYHUN 0DULD+/H[EHUJ European Bioinformatics Institute stage Biotech Company – my • Cinzia Progida • Shuo-Wang Qiao • Charlotta Sandin • Omri Snir • Peter Szodoray •,QJHU‘\QHEUnWHQ Ana-Maria Lennon-Duménil, & WT Sanger Institute, UK Institut Curie, France Understanding cellular Coordinating cell migration heterogeneity André Borka, Head hunter, Borka Consulting, Oslo with function: the example Guest lectures of dendritic cells Gabriel D. Victora, Whitehead (Work)Life after PhD within Institute for Biomedical Research, US the pharmaceutical industry, Arne Akbar, University Matthew Collin, Newcastle Michael Dustin, Oxford Vivianne Malmström, Karolinska Darwin in miniature: medical technical equipment College London, UK University, UK University, Kennedy Institute University hospital, Sweden evolution in germinal centers and life science. Advice Defective T Cell Immuno- Human dendritic cells of Rheumatology, UK Dissecting autoimmunity Hedda Wardemann, Deutsches surveillance During Ageing in health and disease T cell signal integration and - T and B cell responses in applications Krebsforschungszentrum, Germany decision making based on Rheumatoid Arthritis Mats Bemark, University Simon J. Draper, University synapses and kinapses The B cell antibody repertoire Ana Kucera, Regional Sales of Gothenburg, Sweden of Oxford, UK Eric Meffre, Yale University, US in health and disease Manager Carl Zeiss AS, Oslo Beyond the bone marrow Development of broadly- Zoltan Fehervari, Nature The establishment of B cell From PhD to industry: Patrick C. Wilson, University neutralising vaccines against Publishing Group, US tolerance: of humanized mice the pros and cons and of Chicago, US differentiation the blood-stage infection How to get published: and men and Self-reactive the process behind of human malaria the agony and the ecstasy Human antibody responses Andrea Cerutti, Mount Sinai and gut homeostasis defects School of Medicine, US Deborah Dunn-Walters, Frederic Geissmann, King's Gur Yaari, Bar-Ilan University, Israel Class switching at the King's College London, UK College London, UK Lill Mårtensson-Bopp, University Mining B cell repertoire mucosal interface Spectratype and High Differentiation and functions of Gothenburg, Sweden dynamics from next-generation Throughput Sequencing Autoreactive B cells; a road sequencing studies analysis of B cell repertoire to autoimmune disease? CENTRE FOR IMMUNE REGULATION (CIR) 58 FINAL REPORT 2007–2017 59

Hyun-Dong Chang, Deutsches Thorbald van Hall, Leiden Univer- Tissue control of effector Rheuma-Forschungszentrum Berlin, sity Medical Center, the responses Guest lectures a Leibniz Institute, Germany Tumors with processing defects From human to mouse: Reverse - display novel tumor engineering of a mouse model tory Th to chronic by visiting professors via the non-classical HLA-E for CD and other guests Kristian Hannestad, Oslo Kjetill S. Jacobsen, University Yueh-hsiu Chien, Stanford University Hospital of Oslo University, US CIR has arranged an extensive number of seminars, sympo- Anti-nucleosomal in Genome sequence of Atlantic Gamma Delta T cells: First siums and lectures with external international and national a mouse model for SLE cod reveals a unique immune line of Defense and Beyond Adrian Hayday, King’s College system through the loss of MHC VSHDNHUVRSHQIRUWKHZKROHVFLHQWLÀFHQYLURQPHQWLQ2VOR II function Some of the events have been arranged in collaboration with Peter Cresswell, Yale School London, UK of Medicine, US other research centres in Oslo and the Norwegian Society of The dominant role of body sur- Jørgen Jahnsen, Aker University face epithelia in shaping local T Hospital metabolic regulator co-opted by ,PPXQRORJ\([WHUQDOVSHDNHUVKDYHDOVREHHQLQYLWHGWRRXU cell immunity Treatment goals for IBD human cytomegalovirus VHYHQ&,5UHWUHDWV,QWRWDOLQFOXGLQJWKHJXHVWVLQYLWHGE\WKH Dag O. Hessen, University of Oslo postdoc committee, more than 100 different speakers have Sirpa Jalkanen, University of Turku, Mark M. Davis, Stanford University, The Red Queen principle in Finland - CA, US FRQWULEXWHGWRDFWLYLWLHVLQLWLDWHGE\WKHFHQWUH&HQWUHPHP nature and culture ฀ Systems and its bers have also contributed with a multitude of lectures at the as targets to prevent cancer application to human beings Mark Hogarth, Burnet Institute, growth and spread VHPLQDUVDQGV\PSRVLXPV Australia ฀฀ recognition and applications to Antibody and Fc-receptor Leo James, MRC Laboratory of human responses interactions in humans and Molecular Biology, UK other primates. Implications for Intracellular Antibody Immu- Immunology Taught by the development of vaccines, nity and the Cytosolic Fc Recep- Humans therapeutic antibodies and the tor TRIM21 Sigbjørn Fossum, University Intracellular Immunity: target- External speakers and lectures 2007–2017 of Oslo Trygve Holmøy, Oslo University ing and neutralizing The role of APLEC receptors Hospital inside infected cells in adjuvant induced arthritis The immunology of multiple sclerosis Marc Jenkins, University of William Agace, University of Lund, Richard Blumberg, Harvard Maria Bottermann, MRC Johan Garssen, University of Minnesota, US Sweden Medical School, US Laboratory of Molecular Biology, UK Utrecht and Danone Research Patrick Holt, Telethon Institute The CD4+ T cell response to Intestinal Dendritic cells, reti- Endoplasmic Reticulum Stress Adenoviral gene delivery is Centre for Specialised Nutrition, for Child Health Research in bacterial infection The Netherlands noic acid, and their role in the inhibited by sequential comple- Perth, Australia regulation of intestinal T cell ment-mediated virion inactiva- Immunomodulation by dietary Interactions between innate Imre Kacskovics, Eötvös Loránd Regulation of responses tion and TRIM21 neutralization intervention: the cutting edge and adaptive immunity in University, Hungary Function by Carcinoembryonic between food and pharma asthma pathogenesis: new per- Accelerating antibody discov- Antigen Adhesion Molecule 1: Maria Therese Ahlen, The Arctic Søren Buus, University of spectives from studies on acute ery using transgenic animals Marcos González-Gaitán, University of Norway Copenhagen, Denmark exacerbations overexpressing the neonatal Fc and Cancer University of Geneva, Switzerland Fighting FNAIT – murine receptor as a result of aug- Treg-mediated control of models and antibody prophy- The immunobiology of the (not HLA class I predictors and large Sara endosomes during mented humoral immunity IgE-mediated acute phase laxis so) neonatal Fc receptor (FcRn) scale HLA tetramer capabilities asymmetric cell division responses?? for IgG in antigen presentation Frits Koning, Paul Antony, University of *DUHWK*ULIÀWKV University of Oslo Medical Centre, The Netherlands Bana Jabri, University of Maryland, School of Medicine, US IBD pathogenesis human T cell responses Development of biodegradable - Chicago, US Restoring immune function Drug hypersensitivity caused nanoparticles enclosing anti- react between HLA-DQ8 and Juan Bonifacino, NIH, US Host, environment and of tumor associated antigen by alteration of the MHC-pre- biotics against Mycobacterium the Type-1 diabetes-associated Mechanisms of CD4 Down- microbes, a love-hate triangle sented self-peptide repertoire tuberculosis in macrophages ฀฀ regulation by the Nef protein recurrence of melanoma Intraepithelial lymphocytes Harald Carlsen, University of Oslo system at the frontier of adaptive and Christian Kurts, University of Bonn, Switzerland David Artis, University of Optical imaging of gene innate immunity Pennsylvania, US regulation in living mice Signal 0 chemokines enhance Mechanisms of immuno- ฀ regulation at barrier surfaces CENTRE FOR IMMUNE REGULATION (CIR) 60 FINAL REPORT 2007–2017 61

Olivier Lantz, Institut Curie, France Jenny Mjösberg, Karolinska Gøri Perminov, Ahus University Jeffrey V. Ravetch, The Rockefeller Jo Spencer, King's College, Genetic and functional MAIT cells, an evolutionarily Institutet, Sweden Hospital University, New York, US London, UK, interactions between MHC conserved T cell subset with Heterogeneity and plasticity of Mucosal macrophages and reg- Novel roles for IgG glycans From bone marrow to gut-asso- and NK receptors anti-bacterial reactivity innate lymphoid cells in tissue ulatory T cells in pediatric IBD ciated lymphoid tissue; a novel Maria Rescigno, European Institute route in human B cell develop- Histocompatibility Complex Antonio Lanzavecchia, Institute Susan K. Pierce, National Institute of Oncology in Milan, Italy ment (MHC) for Research in Biomedicine, Allan Mowat, University of Allergy and Infectious Diseases, Bacteria as anticancer agents Switzerland of Glasgow, UK National Institutes of Health, US and Probiotics: friends or foes? Jon Sponheim, Oslo University Hendrik Veelken, University Dissecting the human antibody Local control of dendritic cell The acquisition of immunity in Hospital Dendritic cells in the gut: direc- of Leiden, the Netherlands response to pathogens and self and macrophage heterogeneity malaria tors or players of the immune The B-Cell Receptor and antigens in intestinal homeostasis and Regulating the initiation of response? Anne Spurkland, University of Oslo Pathogenesis of B-Cell Lym- antigen-driven B cell responses phomas: A Functional Immu- Jeanette Leusen, University Medi- Dendritic cell-epithelial cell HLA association in multiple nopathology Perspective of cal Center Utrecht, Netherland, Jacques Neefjes, Netherlands A Tale of a Tail Wagging the cross-talk in bacterial handling sclerosis Lymphoid Neoplasia Inside-out regulation of Fc Cancer Institute, The Netherlands Dog. On the generation, main- in the gut receptors; consequences for How Salmonella causes cancer tenance and activation of Harald A. Stenmark, University of 2-photon imaging to visualize Gestur Vidarsson, University antibody therapy of cancer and the epidemics of gallblad- memory B cells Oslo and Oslo University Hospital dendritic cells in the gut of Amsterdam, The Netherlands der carcinoma in India Ubiquitin-mediated endosomal Borrowing from Peter to Regulated IgG Fc-glycosylation Sten Linnarsson, Karolinska sorting - role in growth factor A Genome-wide multidimen- Pay Paul: Why Immunity Mark Shlomchik, University of Institutet, Stockholm, Sweden signalling and cell migration sional siRNA screen to reveal to Malaria is so Slow to be Pittsburgh, US Unbiased cell-type discovery pathways controlling MHC Acquired NETworks in Lupus: T-B or not Ioana Visan, Senior Editor using large-scale single-cell Nils Christian Stenseth, University Nature Immunology class II antigen presentation T-B, DC is the question of Oslo RNA-seq Philippe Pierre, Centre d'Immunol- From bench to publishing High throughput analysis ogie de Marseille-Luminy (CIML), Germinal Center Selection and Plagues: Past, Present and Eric O. Long, – an editorial perspective National Institute of of MHC class II antigen France the Development of Memory B Future Allergy and Infectious Diseases, presentation and how to and Plasma Cells Sally Ward, University of Texas – National Institutes of Health, US A role for the ER stress Andreas Strasser, The Walter make sense of it pathways in dsRNA innate Southwestern Medical Center, US Regulation of NK cell activation How does autoimmunity get and Eliza Hall Institute of Medical A science career? Smart responses started? Mechanistic and thera- Research, Australia FcRn as a global regulator of Annalisa Macagno, Institute moves? peutic implications IgG levels: from single molecule Hidde Ploegh, Whitehead Institute The role of apoptosis in tumor for Research in Biomedicine, imaging to the development Biophysical techniques used to for Biomedical Research, US Development and Function of development and cancer therapy Switzerland of therapeutics Memory B Cells Interplay between immunity Per Thor Straten, Copenhagen Analytic vaccinology and the positioning of late endo- The role of FcRn in IgG homeo- and infectious agents Activation and regulation of University Hospital, Denmark human cytomegalovirus infec- somes and how motor proteins stasis: from protein engineering autoreactive B cells: the mye- tion: from humoral immunity to do the job Fiona Powrie, University of Oxford, T cells; magic bullets in cancer to imaging single molecules loid connection vaccine design UK therapy? David Nemazee, The Scripps Activating Autoreactive B Cells: Inger Helene Madshus, University Host microbial interactions in Kunchithapadam Swaminathan, - Research Institute, US Roles of Tolls, T Cells, and Time of Oslo the intestine and their break- National University of Singapore, ses of FcRn and IgG using high Novel phospholipase family resolution microscopy: implica- Endocytic downregulation of Ziv Shulman, The Weizmann Insti- Singapore proteins in innate immunity disease ErbB proteins tute of Science, Israel Happy marriages among bio- tions for antibody engineering B cell tolerance : Genetics and Gut reactions: Immune path- Dynamic signaling by T follicu- physical techniques Bernard Malissen, Centre d'Immu- vaccinology Kai Wucherpfennig, Harvard ways in the intestine in health lar helper cells during germinal Medical School, Boston, US nologie de Marseille-Luminy (CIML), and disease Pavel Tolar (MRC National Insti- France Johanna Olweus, Oslo University center B cell selection tute for Medical Research, UK) Mechanism of HLA-DM induced Hospital peptide exchange in the MHC Integrative biology of T cell Erlend Smeland, University of Oslo Mechanical extraction of anti- activation and Harnessing skin Manipulating dendritic cells and Oslo University Hospital gens from the B cell immune class II antigen presentation to tease out cancer-targeted T pathway dendritic cells Regulatory mechanisms that Evidence for involvement of synapse: a unique way to meas- cells control intestinal homeostasis the BCR in diffuse large B-cell The Earliest Events in T Luisa Mearin, Leiden University lymphoma development cell Activation Medical Center, The Netherlands Petra Paul, the Netherlands Cancer Gwendalyn Randolph, Washington John Trowsdale, University of Institute, The Netherlands Prevention of coeliac disease: University School of Medicine, US Devin Sok, The Scripps Research Cambridge, UK Isolation of rare memory B Report from an ongoing pediat- The MHC class II pathway Lymphatic transport and Institute, California, US Regulation of MHC genes cells for the generation of of antigen presentation: A therapeutic antibodies ric trial and proteins genome-wide screen and what comes after Exploring mononuclear phago- Genetics and functions of cytes in mouse and man antibodies and their conserved genes in the leukocyte epitopes receptor complex