Downregulated ATP6V1B1 expression acidifies the intracellular environment of cancer cells leading to resistance Title to antibody-dependent cellular cytotoxicity( Dissertation_全文 )
Author(s) Nishie, Mariko
Citation 京都大学
Issue Date 2021-01-25
URL https://doi.org/10.14989/doctor.k22887
Right
Type Thesis or Dissertation
Textversion ETD
Kyoto University Research article
Downregulated ATP6V1B1 expression acidifies the intracellular environment of cancer cells leading to resistance to antibody-dependent cellular cytotoxicity
Running title: Intracellular acidification and loss of antitumor immunity
Mariko Nishie1, Eiji Suzuki1, Masakazu Hattori2, Kosuke Kawaguch1, Tatsuki R. Kataoka3,
Masahiro Hirata3, Fengling Pu1, Takeshi Kotake1, Moe Tsuda1, Ayane Yamaguchi1, Tomoharu
Sugie4, Masakazu Toi1
1Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto,
Japan
2Department of Immunosenescence Graduate School of Medicine, Kyoto University, Kyoto, Japan
3Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
University, Kyoto, Japan
4Department of Breast Surgery, Kansai Medical University, Osaka, Japan
Financial support
This research was supported by a grant from the Japan Society for the Promotion of Science
(KAKENHI Grant Number 24591901).
Corresponding author: Eiji Suzuki