Proquest Dissertations

Total Page:16

File Type:pdf, Size:1020Kb

Proquest Dissertations Healing herbs and dangerous doctors: Local models and response to fevers in northeast Thailand Item Type text; Dissertation-Reproduction (electronic) Authors Pylypa, Jennifer Jean Publisher The University of Arizona. Rights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Download date 03/10/2021 21:13:09 Link to Item http://hdl.handle.net/10150/290045 HEALING HERBS AND DANGEROUS DOCTORS: LOCAL MODELS AND RESPONSE TO FEVERS IN NORTHEAST THAILAND by Jennifer Jean Pylypa A Dissertation Submitted to the Faculty of the DEPARTMENT OF ANTHROPOLOGY In Partial Fulfillment of the Requirements For the Degree of DOCTOR OF PHILOSOPHY In the Graduate College THE UNIVERSITY OF ARIZONA 2004 UMI Number: 3131631 INFORMATION TO USERS The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleed-through, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. UMI UMI Microform 3131631 Copyright 2004 by ProQuest Information and Learning Company. All rights reserved. This microform edition is protected against unauthorized copying under Title 17, United States Code. ProQuest Information and Learning Company 300 North Zeeb Road P.O. Box 1346 Ann Arbor, Ml 48106-1346 THE UNIVERSITY OF ARIZONA a- GRADUATE COLLEGE As members of the Final Examination Committee, we certify that we have Jennifer Jean Pylypa read the dissertation prepared by entitled Healing Herbs and Dangerous Doctors: Local Models and Response to Fevers in Northeast Thailand and recommend that it be accepted as fulfilling the dissertation requirement for the Degree of Doctor of Philosophy Date J. ^teph^i Lansing Date c 1 zA /rc-n i Ana Teresa Ortiz Date 0 , Nancy Fai^zo Da /hj i'h i-P • o? • O V Mimi Nichter Date Final approval and acceptance of this dissertation is contingent upon the candidate's submission of the final copy of the dissertation to the Graduate College. I hereby certify that I have read this dissertation prepared under my direction and recomm.end that it be accepted as fulfilling the dissertation requirement. Dissertation Director Mark Nichter Date 3 STATEMENT BY AUTHOR This dissertation has been submitted in partial fulfillment of requirements for an advanced degree at The University of Arizona and is deposited in the University Library to be made available to borrowers under rules of the Library. Brief quotations from this dissertation are allowable without special permission, provided that accurate acknowledgment of source is made. Requests for permission for extended quotation from or reproduction of this manuscript in whole or in part may be granted by the head of the major department or the Dean of the Graduate College when in his or her judgment the proposed use of the material is in the interests of scholarship. In all other instances, however, permission must be obtained from the author. SIGNED: 4 ACKNOWLEDGEMENTS This dissertation was made possible through the encouragement, kindness, cooperation, and support of many people. First and foremost, my heartfelt thanks go out to the many people in northeast Thailand who welcomed me with characteristic Isan hospitality, and willingly gave their time to answer my endless stream of questions. Weeraform Phuangtum, Terdsak Phuangtum, and Prakit Phromsakha in particular provided me with extensive assistance in learning about and exploring the area. Tanida Tiengtham and Ratsamee Nitthisong provided both great friendship, and invaluable support in conducting the research. I also owe many thanks to Manop Kanato of Srinakarin Hospital for sponsoring this project, and to Daravone Kittiphanh of Vientiane, Laos for her excellent instruction in both the Lao language and culture as well as her friendship. At home in the United States, Carolyn Smith-Morris deserves my gratitude for her continuous, long-distance support and encouragement via email during my fieldwork. I would also like to thank committee members J. Stephen Lansing, Ana Teresa Ortiz, Nancy Parezo, and Mimi Nichter for their feedback and encouragement throughout my graduate career. Finally, my undying gratitude goes to Mark Nichter, an outstanding mentor, teacher, and friend, whose commitment to my education and training has been beyond measure. This research was also made possible by grants from the Social Sciences and Humanities Research Council of Canada (Award No. 752-97-0631), the National Science Foundation (Grant No. 9816972), the Wenner-Gren Foundation for Anthropological Research (Grant No. 453230), and the Department of Anthropology (Riecker Grant) at the University of Arizona. 5 TABLE OF CONTENTS LIST OF ILLUSTRATIONS 9 LIST OF TABLES 10 ABSTRACT 11 PREFACE 13 L INTRODUCTION 18 Symptom Ambiguity and Comorbidity 21 Malaria 24 Dengue and dengue hemorrhagic fever 27 Acute respiratory infections 30 Diarrheal diseases 33 Cultural and Social Factors in Illness Evaluation 34 Cultural illness classifications 36 Diagnostic flexibility: beyond taxonomic illness categorization 39 Subjunctive thinking and provisional diagnoses 42 Situational factors influencing illness evaluation 44 Strategic dimensions of illness labeling 48 Implications of Illness Interrelationships for Disease Prevention and Prevalence 52 The Research Context: Local Concerns about Febrile Illness in Northeast Thailand 54 The Dissertation: Outline of Chapters 59 11. SETTING AND METHODS 62 The Region: Northeast Thailand 64 Economic and Health Status of Isan 69 The Research Setting: Life and Health Along the Border 74 Village Life 78 6 TABLE OF CONTENTS - Continued Economics, Subsistence, and Migration 83 Family Structure, Gender Relations, and Child Care Patterns 92 The Three Study Villages: Na Di, San Huat, and Nong Tao 99 Methods 105 Summary: Research in the Northeast Thai Context 115 III. TREATMENT RESOURCES: FROM VILLAGE TO HOSPITAL 117 Formal Health Providers 118 Village health volunteers 122 Government health posts 124 Hospitals 126 Malaria clinics 127 Private clinics 129 Informal Sources of Pharmaceuticals 133 Self-medication 134 Mo theuan: informal providers 138 Traditional Practitioners 139 Mo yapheunban: herbalists 141 Mo pao: blowing experts 143 Mo phi/mo tham: spirit experts 144 Community vs. Formal Health Provider Knowledge and Authority 147 IV. MODELS AND MANAGEMENT OF EARLY CHILDHOOD ILLNESSES: DIARRHEAL DISEASES AND ACUTE RESPIRATORY INFECTIONS 151 Part 1. Cultural Models of Fever 152 Part II. Diarrheal Disease 159 7 TABLE OF CONTENTS - Continued Prevalence and transmission in the Thai context 159 Diarrhea as 'illness': local categories and characteristics 166 Cultural conceptions of cause and prevention for diarrheal illness 168 Treatment practices and the use of oral rehydration solution 175 Thai su: diarrhea as infant development 182 Models vs. practice: situational diagnosis and management of thai su 187 Implications of cultural models of diarrhea 193 Part III. Acute Respiratory Infections 195 Prevalence and risk factors 196 Local categories of ARI 198 Cultural models of pneumonia and abnormal breathing 200 Perceived causes of ARI 205 Mothers' management and treatment of ARI 207 Key issues in the ethnography of ARI 211 Childhood Illnesses in Sociocultural Context 213 V. COMMUNITY MODELS, PREVENTION, AND TREATMENT OF VECTOR- BORNE DISEASES: MALARIA AND DENGUE FEVER 218 Part I. Malaria 220 Overview: malaria in Thailand 220 Malaria and malaria control in Lin Mai District 224 Local models of malaria epidemiology and prevention 228 Symptom evaluation, home diagnosis, and treatment 238 Implications of local models of malaria 245 Part II. Dengue and Dengue Hemorrhagic Fever 248 Dengue in global and Thai perspective 248 Approaches to dengue prevention and control 253 Dengue and dengue control in Lin Mai District 260 Local models of dengue epidemiology and prevention 267 Models and management of dengue illness 278 Community participation in prevention: implications of local models of dengue 288 Making Sense of Infectious Disease: Hybrid Models and Diagnostic Complexity 292 8 TABLE OF CONTENTS - Continued VL HEALING HERBS AND DANGEROUS DOCTORS: THE FOLK ILLNESS KHAI MAKMAI 297 Prevalence and Characteristics of Khai Makmai 298 Illness Taxonomies 302 Incompatibility with Foods and Medicines 310 Health Providers and the Mistreatment of Khai Makmai 314 Deaths from Mismanagement of Khai Makmai 318 Treatment Strategies 322 Ambiguous, Provisional, and Situational Diagnoses 329 Illness Interrelationships: Khai Makmai and Diarrhea, ARI, and Malaria.... 335 Khai Makmai and Dengue Fever 340 Discourses of Blame, Responsibility, and Competency 345 Implications of Khai Makmai for the Treatment of Infectious Diseases 351 Vn. CONCLUSIONS 356 Lessons for Health Services Provision and Health Education 356 Lessons for Medical Anthropology 365 APPENDIX A: TRANSLITERATION OF ISAN TERMS 369 APPENDIX B: GLOSSARY OF ISAN TERMS 374 NOTES 381 REFERENCES 401 LIST OF ILLUSTRATIONS FIGURE 1: Map of three primary study villages, Lin Mai Town, and associated health services 101 FIGURE 2: Aedes mosquito breeding sites:
Recommended publications
  • Data-Driven Identification of Potential Zika Virus Vectors Michelle V Evans1,2*, Tad a Dallas1,3, Barbara a Han4, Courtney C Murdock1,2,5,6,7,8, John M Drake1,2,8
    RESEARCH ARTICLE Data-driven identification of potential Zika virus vectors Michelle V Evans1,2*, Tad A Dallas1,3, Barbara A Han4, Courtney C Murdock1,2,5,6,7,8, John M Drake1,2,8 1Odum School of Ecology, University of Georgia, Athens, United States; 2Center for the Ecology of Infectious Diseases, University of Georgia, Athens, United States; 3Department of Environmental Science and Policy, University of California-Davis, Davis, United States; 4Cary Institute of Ecosystem Studies, Millbrook, United States; 5Department of Infectious Disease, University of Georgia, Athens, United States; 6Center for Tropical Emerging Global Diseases, University of Georgia, Athens, United States; 7Center for Vaccines and Immunology, University of Georgia, Athens, United States; 8River Basin Center, University of Georgia, Athens, United States Abstract Zika is an emerging virus whose rapid spread is of great public health concern. Knowledge about transmission remains incomplete, especially concerning potential transmission in geographic areas in which it has not yet been introduced. To identify unknown vectors of Zika, we developed a data-driven model linking vector species and the Zika virus via vector-virus trait combinations that confer a propensity toward associations in an ecological network connecting flaviviruses and their mosquito vectors. Our model predicts that thirty-five species may be able to transmit the virus, seven of which are found in the continental United States, including Culex quinquefasciatus and Cx. pipiens. We suggest that empirical studies prioritize these species to confirm predictions of vector competence, enabling the correct identification of populations at risk for transmission within the United States. *For correspondence: mvevans@ DOI: 10.7554/eLife.22053.001 uga.edu Competing interests: The authors declare that no competing interests exist.
    [Show full text]
  • Species Diversity and Insecticide Resistance Within the Anopheles
    Species diversity and insecticide resistance within the Anopheles hyrcanus group in Ubon Ratchathani Province, Thailand Anchana Sumarnrote, Hans Overgaard, Vincent Corbel, Kanutcharee Thanispong, Theeraphap Chareonviriyaphap, Sylvie Manguin To cite this version: Anchana Sumarnrote, Hans Overgaard, Vincent Corbel, Kanutcharee Thanispong, Theeraphap Chare- onviriyaphap, et al.. Species diversity and insecticide resistance within the Anopheles hyrcanus group in Ubon Ratchathani Province, Thailand. Parasites & Vectors, 2020, 13, pp.525. 10.1186/s13071- 020-04389-4. hal-03083171 HAL Id: hal-03083171 https://hal.archives-ouvertes.fr/hal-03083171 Submitted on 15 Feb 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License Sumarnrote et al. Parasites Vectors (2020) 13:525 https://doi.org/10.1186/s13071-020-04389-4 Parasites & Vectors RESEARCH Open Access Species diversity and insecticide resistance within the Anopheles hyrcanus group in Ubon Ratchathani Province, Thailand Anchana Sumarnrote1, Hans J. Overgaard1,2,3, Vincent Corbel1,2, Kanutcharee Thanispong4, Theeraphap Chareonviriyaphap5 and Sylvie Manguin6* Abstract Background: Members of the Anopheles hyrcanus group have been incriminated as important malaria vectors. This study aims to identify the species and explore the insecticide susceptibility profle within the Anopheles hyrcanus group in Ubon Ratchathani Province, northeastern Thailand where increasing numbers of malaria cases were reported in 2014.
    [Show full text]
  • Scientific Note
    Journal of the American Mosquito Control Association, 18(4):359-363' 2OOz Copyright @ 2002 by the American Mosquito Control Association' Inc' SCIENTIFIC NOTE COLONIZATION OF ANOPHELES MACULAZUS FROM CENTRAL JAVA, INDONESIA' MICHAEL J. BANGS,' TOTO SOELARTO,3 BARODJI,3 BIMO P WICAKSANA'AND DAMAR TRI BOEWONO3 ABSTRACT, The routine colonization of Anopheles maculatus, a reputed malaria vector from Central Java, is described. The strain is free mating and long lived in the laboratory. This species will readily bloodfeed on small rodents and artificial membrane systems. Either natural or controlled temperatures, humidity, and lighting provide acceptable conditions for continuous rearing. A simple larval diet incorporating a l0:4 powdered mixture of a.i"a beef and rice hulls proved acceptable. Using a variety of simple tools and procedures, this colony strain appears readily adaptable to rearing under most laboratory conditions. This appears to be the first report of continuous colonization using a free-mating sffain of An. maculatus. Using this simple, relatively inexpensive method of mass colonization adds to the short list of acceptable laboratory populations used in the routine production of human-infecting plasmodia. KEY WORDS Anopheles maculatus, Central Java, colonization, larval diet, malaria vector, Indonesia Anop he Ie s (Ce ll ia) maculat us Theobald belongs nificantly divergent in phylogenetic terms from oth- to the Theobaldi group of the Neocellia series, er members of the complex and may represent one which also includes Anopheles karwari (James) and or more separate species awaiting formal descrip- Anopheles theobaldi Giles (Subbarao 1998). The tion (Rongnoparut, personal communication). For An. maculatus species complex is considered an purposes of this article, the Central Java strain will "spe- important malaria vector assemblage over certain be referred to as An.
    [Show full text]
  • The Global Public Health Significance of Plasmodium Vivax Katherine E
    University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Public Health Resources Public Health Resources 2012 The Global Public Health Significance of Plasmodium vivax Katherine E. Battle University of Oxford Peter W. Gething University of Oxford Iqbal R.F. Elyazar Eijkman-Oxford Clinical Research Unit, Jalan Diponegoro No. 69, Jakarta, Indonesia Catherine L. Moyes University of Oxford, [email protected] Marianne E. Sinka University of Oxford See next page for additional authors Follow this and additional works at: http://digitalcommons.unl.edu/publichealthresources Battle, Katherine E.; Gething, Peter W.; Elyazar, Iqbal R.F.; Moyes, Catherine L.; Sinka, Marianne E.; Howes, Rosalind E.; Guerra, Carlos A.; Price, Ric N.; Baird, J. Kevin; and Hay, Simon I., "The Global Public Health Significance of Plasmodium vivax" (2012). Public Health Resources. 366. http://digitalcommons.unl.edu/publichealthresources/366 This Article is brought to you for free and open access by the Public Health Resources at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Public Health Resources by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Authors Katherine E. Battle, Peter W. Gething, Iqbal R.F. Elyazar, Catherine L. Moyes, Marianne E. Sinka, Rosalind E. Howes, Carlos A. Guerra, Ric N. Price, J. Kevin Baird, and Simon I. Hay This article is available at DigitalCommons@University of Nebraska - Lincoln: http://digitalcommons.unl.edu/ publichealthresources/366 CHAPTER ONE The Global Public Health Significance of Plasmodium vivax Katherine E. Battle*, Peter W. Gething*, Iqbal R.F. Elyazar†, Catherine L. Moyes*, Marianne E. Sinka*, Rosalind E. Howes*, Carlos A. Guerra‡, Ric N.
    [Show full text]
  • Vectors of Malaria and Filariasis in Indonesia
    VECTORS OF MALARIA AND FILARIASIS IN INDONESIA Hoedojo* ABSTRACT Malaria at present is still one of the important mosquito-borne diseases in Indonesia. The disease is widespread all over the country and involves nearly all islands. Sixteen Anopheles species have been reconfirmed as malaria vectors. They were distributed geographi- cally as follows: Coastal areas and lagoons ----- An sundizicus and An.subpictus Cultivated ricefields and swampy areas ----- An.aconitus, An.barbirostris, Annigerrimus and An .sinensis Forest inland areas in shaded temporary pools, muddy animal wallows and hoof-prints ----- An.balabacensis, An.bancrofti, Anfarauti, An.koliensis and Anpunctulatus Swamp forest edge in ditches with vegeta- ----- An.1etifer and An.1udlowae tion Hilly areas in seepages, streams and clear moving water ----- Anflavirostris, An.maculatus and Anminimus. The species (of most general importance is An.sundaicus, which is restricted) by its preference for brackish water and is prevalent in coastal areas of Java. Their types in behaviour of An.sundaicus appear as follows : 1. Ansumlaicus in South Coast of Java in general. This species is essentially anthropophilic, exophagic and rests outdoor. It shows susceptible to DDT. 2. An.sundaicus in Cilacap, Central Java. This mosquito is a pure anthropophilic form. It bites man in houses and outdoors, rests indoors and is known resistant to DDT. 3. An.sundaicus in Yogyakarta and Purworejo, Central Java. This mosquito is a strong zoophilic species. It rests and prefers to bite outdoors and shows tolerance to DDT. Human filariasis in Indonesia is the result of infection by three endemic species, namely, Wuchereria bancrofti, Brugia malayi, and Brugia timori.W.bancrofti infection is found in both urban and rural areas.
    [Show full text]
  • Aedes Albopictus Diversity and Relationships in South-Western
    Artigas et al. Parasites Vectors (2021) 14:333 https://doi.org/10.1186/s13071-021-04829-9 Parasites & Vectors RESEARCH Open Access Aedes albopictus diversity and relationships in south-western Europe and Brazil by rDNA/ mtDNA and phenotypic analyses: ITS-2, a useful marker for spread studies Patricio Artigas1, Marta Reguera‑Gomez1, María Adela Valero1, David Osca1, Raquel da Silva Pacheco1,2, María Goreti Rosa‑Freitas3, Teresa Fernandes Silva‑do‑Nascimento3, Claudia Paredes‑Esquivel4, Javier Lucientes5, Santiago Mas‑Coma1 and María Dolores Bargues1* Abstract Background: Aedes albopictus is a very invasive mosquito, which has recently colonized tropical and temperate regions worldwide. Of concern is its role in the spread of emerging or re‑emerging mosquito‑borne diseases. Ae. albopictus from south‑western Europe and Brazil were studied to infer genetic and phenetic diversity at intra‑individ‑ ual, intra‑population and inter‑population levels, and to analyse its spread. Methods: Genotyping was made by rDNA 5.8S‑ITS‑2 and mtDNA cox1 sequencing to assess haplotype and nucleo‑ tide diversity, genetic distances and phylogenetic networks. Male and female phenotyping included combined landmark‑and outlined‑based geometric morphometrics of wing size and shape. Results: Specimens from seven populations from Spain, France and Brazil provided 12 cox1 and 162 5.8S‑ITS‑2 haplotypes, with great genetic variability diference between both markers (0.9% vs 31.2%). Five cox1 haplotypes were shared with other countries, mainly Italy, USA and China, but none was shared between Europe and Brazil. The 5.8S‑ITS‑2 showed 2–7 intra‑individual (mean 4.7) and 16–34 intra‑/inter‑population haplotypes (24.7), including haplotypes shared between Spain, France and Brazil.
    [Show full text]
  • Natural Human Plasmodium Infections in Major Anopheles Mosquitoes in Western Thailand
    UC Irvine UC Irvine Previously Published Works Title Natural human Plasmodium infections in major Anopheles mosquitoes in western Thailand. Permalink https://escholarship.org/uc/item/11m8r7dj Journal Parasites & vectors, 9(1) ISSN 1756-3305 Authors Sriwichai, Patchara Samung, Yudthana Sumruayphol, Suchada et al. Publication Date 2016-01-13 DOI 10.1186/s13071-016-1295-x Peer reviewed eScholarship.org Powered by the California Digital Library University of California Sriwichai et al. Parasites & Vectors (2016) 9:17 DOI 10.1186/s13071-016-1295-x RESEARCH Open Access Natural human Plasmodium infections in major Anopheles mosquitoes in western Thailand Patchara Sriwichai1, Yudthana Samung1, Suchada Sumruayphol1, Kirakorn Kiattibutr1,5, Chalermpon Kumpitak5, Anon Payakkapol1, Jaranit Kaewkungwal2, Guiyun Yan3, Liwang Cui4 and Jetsumon Sattabongkot5* Abstract Background: The Thai-Myanmar border is a remaining hotspot for malaria transmission. Malaria transmission in this region continues year-round, with a major peak season in July-August, and a minor peak in October-November. Malaria elimination requires better knowledge of the mosquito community structure, dynamics and vectorial status to support effective vector control. Methods: Adult Anopheles mosquitoes were collected using CDC light traps and cow bait in 7 villages along the Thai-Myanmar border in January 2011 - March 2013. Mosquitoes were determined to species by morphological characters. Plasmodium-positivity was determined by circumsporozoite protein ELISA. Results: The 2986 Anopheles mosquitoes collected were assigned to 26 species, with Anopheles minimus sensu lato (s.l.) (40.32 %), An. maculatus s.l. (21.43 %), An. annularis s.l. (14.43 %), An. kochi (5.39 %), An. tessellatus (5.26 %), and An. barbirostris s.l.
    [Show full text]
  • Observations on Nocturnal Biting Activity and Host Preference of Anophelines Collected in Southern Thailandi
    Journal of the American Mosquito Control Association, l2(l):52_57, 1996 OBSERVATIONS ON NOCTURNAL BITING ACTIVITY AND HOST PREFERENCE OF ANOPHELINES COLLECTED IN SOUTHERN THAILANDI RAMPA RATTANARITHIKUL.,3 EUI KONISHI3 INo KENNETH J. LINTHICUM, ABSTRACT. Over a l3-month period, 5,127 adrlt female mosquitoes were collected on human bait during multiple collecting periods between 1800 and 06O0 h in 5 villages in southern Thailand. There were marked differences in the biting activity ofdifferent species at each ofthe villages studied. Anopheles maculatus and, Anopheles sawadwongporni were collected most often at dusk or in the first hours of darkness between 1800 and 2100 h. Although specimens of Anopheles dirus were collected consistently between 1900 and 0400 h, peak collections were made between 2000 and 2300 h. Anopheles minimus was collected consistently throughout the night without a clearly discernible peak. Of more than 2,40O Anopheles mosquitoes collected in CDC light traps, 133 specimens (5.4Vo) contained blood, nearly all of which was identified by enzymeJinked immunosorbent assay (ELISA) to be of bovine origin. Ten spec- imens contained blood from more than one host species. INTRODUCTION to villages in Phetchaburi, Prachaup Khiri Khan, and Chumphon provinces in southern Thailand Although Anopheles dirus Peyton and Harri- near the Myanmar border. Details concerning son and Anopheles minimus Theobald are con- climate, geography, and human and animal pop- sidered to be the principal vectors of malaria ulations at the collection sites are presented in throughout much of Thailand (Rosenberg et al. an accompanying paper (Rattanarithikul et al. 1990), little is known about the ecology of an- 1996b).
    [Show full text]
  • Mutations in the Voltage-Gated Sodium Channel Gene of Anophelines And
    Silva et al. Parasites & Vectors 2014, 7:450 http://www.parasitesandvectors.com/content/7/1/450 REVIEW Open Access Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review Ana Paula B Silva1, Joselita Maria M Santos1 and Ademir J Martins2,3* Abstract Constant and extensive use of chemical insecticides has created a selection pressure and favored resistance development in many insect species worldwide. One of the most important pyrethroid resistance mechanisms is classified as target site insensitivity, due to conformational changes in the target site that impair a proper binding of the insecticide molecule. The voltage-gated sodium channel (NaV) is the target of pyrethroids and DDT insecticides, used to control insects of medical, agricultural and veterinary importance, such as anophelines. It has been reported that the presence of a few non-silent point mutations in the NaV gene are associated with pyrethroid resistance, termed as ‘kdr’ (knockdown resistance) for preventing the knockdown effect of these insecticides. The presence of these mutations, as well as their effects, has been thoroughly studied in Anopheles mosquitoes. So far, kdr mutations have already been detected in at least 13 species (Anopheles gambiae, Anopheles arabiensis, Anopheles sinensis, Anopheles stephensi, Anopheles subpictus, Anopheles sacharovi, Anopheles culicifacies, Anopheles sundaicus, Anopheles aconitus, Anopheles vagus, Anopheles paraliae, Anopheles peditaeniatus and Anopheles albimanus) from populations of African, Asian and, more recently, American continents. Seven mutational variants (L1014F, L1014S, L1014C, L1014W, N1013S, N1575Y and V1010L) were described, with the highest prevalence of L1014F, which occurs at the 1014 site in NaV IIS6 domain.
    [Show full text]
  • Proorarol Hoolor, OHO Also Contains an Illustrated Taxonomic Voy to 1' St,Rries of Anonheline Larvae
    DOCTIMFVT RFSUMF FP 011. bU4 010 hug Tratt, Farry P. olanovici-, Chr-trr 3. Vorkook or thc T(lcntificati.or of Arotl--0,,E /Arva. Frolim3nary TssuP. "757-7TT1770!: National Cor,munical,le r'isqarr Cor,tc'rU.T1"V), Atlanta, C.a. r'' ft 'Ar-7 rF. ,T117.-r frn. F'TCH Frrq ?rico "17-4n.'70 VC-.Lr) 7)",C77nTr" Autoinstructional Ai6s, *Tiolooy, rrtonloiv, Occunators Flucatior, e-rt!F;tructionAl tcrials, *Prouramerl !,"atcrials, Public "caltl, *-axonory APFTI'AC- This self-insfructional hooklot el«.7i_on(,1 to crahlo malarial control workors to iArntify the larvAr of "rnol'v'r1,*" snociPs that arc imnor+art ralaria vectors. -0 feat -urns of 410 larvae aro illustratoA in 9 proorArol hoolOr, OHO also contains an illustrated taxonomic voy to 1' st,rries of anonheline larvae. olossary and asl-,ort 1,ihliortrary arm (PI) ,,,. ,-,,;. ,:"-.4. - . .'?' ::,-,..1,..- -''' '''',-,'-,.' '-'.-:' '- - -..'.--. --.. '... , , . ,. -..,--: .,-, ','''.:-5.f'1.if!.''' f*.c' ,',,',--''.. ,t ',...','', ''. .,....,, ,. ,r.,. re ,, , ;' , .'s,''../,' ,' 4;',1-!,--17.0"t ' k c'-- i;,' -...-:' '.,;'".4. ,...'',... ''.*,',...'' .:ff' 4 , , ,',.';'. -(:;',. "-0 ...,...".."4.,!, ,.,, ,1"..,'', ''4'.' ' P''''''''-' '' ,:44.,./A t;;A:-.,, , . , , ..,. f- . I....., t'' ''...'1'.'''.:''') , "..f A '. -,;1 ,4.: , '4> ,r . .:,11 ."' t A.'.'.'e -,', .1...."'1".'L.'"`.. -. ' , 4 ,0 , i, i ' ''. .4 ; .1' i'''',. '. ." 5.' '''':): ...17;' '-!:,, 44''''''''''41I' ''' ';'°Ii , ,!.11,7, ' : . ' ,',1 o ), %' ' 11', , 1, , RKBOOK ON THkIDENTIFICATION):'...,% :c4F.y! '1;- .,. ANOPHELES LA V I `4"ie' 4- 51 i k. 4 5t , ,t; I4 '1 .! f.1if",fi ' 4 *"*4*"1 ) 4, , ", .."4' : '' r " . c , ., . , % .; r ,; . , f./ . 4, .;!4;.:; )4: r .1.4 '" .:; . ,..- 4,''"' . ..,-, , jj 4' ,C. -',..; . /* 4. ',.! 4/ ,.'0, . '. ' ''*. ',"' '',... '.0, 7'.........10'' 00 4,- -t,p 'Jos,*".
    [Show full text]
  • Anopheline Species Complexes in South and South-East Asia WHO Library Cataloguing-In-Publication Data World Health Organization, Regional Office for South-East Asia
    SEARO Technical Publication No. 57 Vector-borne diseases are a major health problem in the South-East Asia Region and in other parts of the world. There are about 4 500 mosquito species in existence; species belonging to the Anopheles genus transmit malaria. Combating malaria is part of the Millenium Development Goals, and vector control is a key strategy both regionally and globally. Therefore, the review and dissemination of information on vector species is critically important. Most of the anophelines that are involved in the transmission of malaria in South and South-East Asia have been identified as species complexes. Members of a species complex are reproductively isolated evolutionary units with distinct gene pools and, hence, they differ in their biological characteristics. In 1998, WHO published Anopheline species complexes in South-East Asia. New identification tools have been developed since then, and therefore this updated edition is being published. It summarizes work that has been done on anopheline cryptic species and will be highly valuable to researchers, field entomologists and malaria- control programme managers. AAnnoopphheelliinnee SSppeecciieess CCoommpplleexxeess iinn SSoouutthh aanndd SSoouutthh--EEaasstt AAssiiaa ISBN 978-92-9022-294-1 9 7 8 9 2 9 0 2 2 2 9 4 1 SEARO Technical Publication No. 57 Anopheline Species Complexes in South and South-East Asia WHO Library Cataloguing-in-Publication data World Health Organization, Regional Office for South-East Asia. Anopheline Species Complexes in South and South-East Asia. 1. Anopheles 2. Species Specificity 3. Sibling Relations 4. Insect Vectors 5. South-East Asia 6. Asia, Western ISBN 978-92-9022-294-1 NLM Classification No.
    [Show full text]
  • Abdu Phd Thesis 2016
    Investigating the role of glutathione and glutathione biosynthetic genes in the adaptation of Anopheles gambiae to insecticides By Habibu Usman Abdu BSc, MSc A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in the School of Science, Engineering and Technology, Abertay University Dundee, United Kingdom NOVEMBER, 2015 DEDICATION This thesis is dedicated to my beloved parents; Late Alhaji Usman Abdu and Late Hajiya Binta Bala, Whose guidance and love shall never be forgotten, may their gentle souls rest in peace Ameen Habibu, U.A - ii- Abertay University, Dundee, UK AUTHOR’S DECLARATION I, HABIBU USMAN ABDU declare that this thesis is my own, unaided work. It is being submitted for the Degree of Doctor of Philosophy at the Abertay University, Dundee, United Kingdom. It has not been submitted before for any degree or examination in any other University. 29th day of March, 2016 (Signed) Address: 2L, Malcolm Street Dundee, DD4 6SG United Kingdom Habibu, U.A - iii- Abertay University, Dundee, UK CERTIFICATION I certify that HABIBU USMAN ABDU, a PhD candidate has undertaken all the work described herein and is based on the original work done at the Abertay University, Dundee in partial fulfilment for the requirements for the award of Doctor of Philosophy in Molecular Entomology. This has not previously formed the basis for the award of any degree, diploma, associateship, fellowship or any similar title and represents an independent work on the part of the candidate. (Signature of the Principal Supervisor) Dr Deeni Y. Yusuf, School of Science, Engineering and Technology (SSET), Dundee, DD1 1HG, United Kingdom Habibu, U.A - iv- Abertay University, Dundee, UK ACKNOWLEDGMENTS First of all, my ultimate gratitude is to Almighty Allah (S.W.A) who has given me life, excellent health, which I have always enjoyed and guided me through this research work.
    [Show full text]