Hindawi BioMed Research International Volume 2021, Article ID 9931885, 7 pages https://doi.org/10.1155/2021/9931885 Research Article Effects of Aspirin on Myocardial Ischemia-Reperfusion Injury in Rats through STAT3 Signaling Pathway Zhenjun Wu ,1 Xuewen Li,2 Xiuyue Li,3 and Lihua Yu4 1Cardiology Department, Tianjin Huaxing Hospital, Tianjin 300270, China 2Cadre’s Ward, Characteristic Medical Center of Chinese People’s Armed Police Force 300, Tianjin 300171, China 3Cardiology Department, Xianshuigu Hospital of Jinnan District, Tianjin 300350, China 4Beijing Chaoyang Integrative Medicine Emergency Medical Center, Beijing 100022, China Correspondence should be addressed to Zhenjun Wu;
[email protected] Received 26 March 2021; Accepted 29 June 2021; Published 9 July 2021 Academic Editor: Junyan Liu Copyright © 2021 Zhenjun Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To investigate the role and mechanism of aspirin in myocardial injury induced by myocardial ischemia-reperfusion in rats through STAT3 signaling pathway. Methods. Sixty rats were randomly divided into three groups: the sham operation group, MI/R group, and MI/R+aspirin group (aspirin group). The rats in the sham operation group did not ligate the LAD coronary artery, while the aspirin group ligated the LAD coronary artery, which caused the suture to be loosened after 30 minutes ischemia, and 60 mg/kg aspirin was injected into the tail vein 10 minutes before reperfusion. After three hours of reperfusion, the ultrasound system was used to collect hemodynamic parameters, including ejection fraction (EF%), shortening fraction (FS%), and left ventricular end-systolic pressure (LVESP%) and left ventricular end-diastolic pressure (LVEDP%).