Supporting Document Document 1 of CCHD Screening to Reduce

Total Page:16

File Type:pdf, Size:1020Kb

Supporting Document Document 1 of CCHD Screening to Reduce Queen Sirikit National Institute of Child Health Year of nomination 2018 Supporting document Document 1 of CCHD Screening to Reduce Neonatal Mortality in Thailand Content Page Executive Summary 1 Background, Situation and Problem 5 Evaluation of the Initiative 7 Innovations of the Initiative 14 Implementation of the Initiative 19 Stakeholders 24 Resources 26 Monitoring and Evaluation System 28 Results 30 Obstacles and Solutions 33 Benefits and Mutual Benefit 35 Sustainability and Transferability of the Initiative 39 Success Story 42 Lesson Learned 53 Future Challenges 54 Acknowledgement 55 TITLE: CCHD Screening to Reduce Neonatal Mortality in Thailand 1. Executive Summary 1.1 Problem: According to a 2012 World Bank report, the neonatal mortality rate in Thailand was 8.3 per 1,000 live births. This is much higher compared to Malaysia’s 4 per 1,000 live births and Singapore’s 1 per 1,000 live births. One of the Sustainable Development Goals’ (SDGs) targets is to end preventable deaths of newborns and less than 5 years old age which the success confirms by the index mortality rate of children fewer than 5 and neonatal mortality. Because neonatal mortality is approximate 50% of the mortality of children under 5, so that the newborn babies are vulnerable and need to be given special attention. Thailand has also been working to reducing the neonatal mortality rate as the ultimate goal of Thai National Health Service Plan for newborn. Critical congenital heart diseases (CCHD) are prevailing problem worldwide. In Thailand, approximate 1,000 babies are born annually with CCHD, one important cause of Thai’s neonatal mortality. Though, newborn babies undergo routine physical examinations within 24 - 48 hours after delivery, CCHD may not be identified particularly those do not exhibit symptoms. However, after returning home, a neonate with congenital heart disease will develop severe symptoms and die before the family can bring him to the hospital or may arrive at the hospital in the critical condition. CCHD can be severe and the risk of death can become very high, also any number of crippling complications those will leads to other social and economic problems at the individual, family, society and country levels that result due to bereavement from loss of beloved babies or the family need to take care of disable babies. If an infant with congenital heart disease already exhibit severe symptoms, he needs to be taken care of - 1 - at tertiary hospital with the necessary facilities and expertise. A newborn patient with congenital heart disease may also need to remain in the hospital for a longer period of time to receive the needed treatment. As a result, the medical expenses for the family can be extremely high. Another problem is that the longer a congenital heart disease patient has to stay in the hospital, the lower the turnover rate for beds for critically ill patients. Consequently, the overall operation and image of the hospital can be negatively impacted. It can be concluded that overall treatment for newborns with critical congenital heart disease in Thailand was reactive. Thus affect Thailand’s goal of reducing the neonatal mortality rate in Thailand. 1.2 Development of the Initiative The Center of Excellence (COE) in Pediatric Cardiology is one center of excellence of Queen Sirikit National Institute of Child Health (QSNICH), the major public healthcare provider and policy maker for the improvement of healthcare service for newborns and children in Thailand, realizes the problem and commit to end preventable deaths of newborns due to CCHD and serving the Ministry of Public Health (MOPH) policy of reducing Neonatal Mortality. Currently QSNICH provides services to more than 1,300 to 1,400 child patients with congenital heart defects each year or approximately one out of every four such patients across the country because of their ability in doing the complete accurate diagnostic and give them comprehensive treatment. After studying the treatment chain for newborn with CCHD and found that the delayed of diagnosis and treatment is the most important factor that compromised this chain, QSNICH searched for the proactive prevented tool which is the pulse oximetry (PO) screening in newborns that will - 2 - detect those newborns with CCHD before they develop the severe symptoms and be critically ill. The PO screening is a simple, painless, noninvasive, no risk and inexpensive technic, using simple device available in all hospitals, and gives reliable results. All trained health personnel can do the screening. Early detection of heart defects leads to the required proper monitoring and following up with pediatric cardiologists and establishing early treatment will also help decrease morbidity and mortality among these newborns. Since 2002, studies of PO screening have shown a variety of criteria and effectiveness of this screening that has been accepted and recommended worldwide, but only few countries have adopted it as a mandatory public service for newborn. The research and development of PO screening was conducted to determine the most appropriate criteria and effectiveness of its implementation across the country by QSNICH and partners. Thus QSNICH initiates the innovative public service “CCHD Screening to Reduce Neonatal Mortality in Thailand” in 2013. The initiative aims to end preventable death of newborn with CCHD in Thailand by implement of the PO screening service in all hospitals providing the newborn delivery across the country. This involves the introduction of the PO screening to all relevant healthcare providers, training them and developing of the innovative interpreting tools to ensure effective detection of newborns with CCHD: the BB wheel interpretative tools, CCHD screening application, and the web- based data collection and system evaluation program for the hospitals implementing CCHD screening to report easily, and convince them that the screening is the procedure that worth to do since it can really save those newborns with CCHD. The PO screening for CCHD has since been adopted and included as public service, added to the routine physical examination for newborns. Furthermore it has been integrated into national newborn service plan to ensure the greatest and fastest of its transferability and sustainability. - 3 - 1.3 Impact of the Initiative The initiative is established in 2013 then continuously expanded its network across the country. Recently the initiative has gained attention and been integrated into the national newborn service plan as the mandatory public service for newborns. The initiative also reaches out to the population by raising awareness, creating public demand to support health and well-being of these vulnerable newborns. It has significantly impacted the lives of the most vulnerable newborns, especially those with CCHD as shown by the evaluating system: 1. The number of hospitals implementing CCHD screening increased from 4 to 208 in 56 provinces 13 healthcare regions of Thailand within 5 years of the initiative, meaning the service provision has expanded to many areas of Thailand and that there is a good trend for partner cooperation. 2. The number of hospitals has grown rapidly after launch of the innovative CCHD screening smart phone application. 3. Newborns receiving screening have risen in number from thousand to hundreds of thousands annually meaning more children’s lives have been saved before it’s too late and that equality in access to the public service is promoted. 4. The number of newborns with positive screening results confirms the ability of health personnel to detect at-risk newborns and give them timely comprehensive lifesaving treatment. 5. the most important impact is the gradual drop in neonatal mortality thanks to the national healthcare service plan for newborns which includes the screening. According to a World Bank report, the rate has decreased from 8.3/1,000 live births in 2012 to 7.3/1,000 live births in 2016. - 4 - 1.4 Challenges of the Future The challenges of the initiative at the end of the Twelfth National Healthcare Development plan are to 1. Expand the PO screening service in newborns to 100% of hospitals providing newborns delivery in Thailand. 2. Have the formal MOU with NSHO to support the operational budget to all hospitals providing the PO screening service in all 13 Thailand’s s as in 13th. 3. Have at least 60% of newborns in Thailand each year receive the PO screening within 24-48 hours before discharging from the hospitals. These will confirm the true success of this innovative public service “CCHD Screening to Reduce Neonatal Mortality in Thailand” and the realization of Thai government, Ministry of Public Health to the Agenda 2030 Sustainable Development Goals and Targets as; SDG3, target3.2, 3.4, 3.8, 3.c and 3.d; SDG1, target 1.1; and SDG10, target10.3. 2. Background, Situation and Problems According to a 2012 World Bank report, the neonatal mortality rate in Thailand was 8.3 per 1,000 live births. This is much higher compared to Malaysia’s 4 per 1,000 live births and Singapore’s 1 per 1,000 live births. One of the sustainable development goals’ (SDGs) targets is to end preventable deaths of newborns and less than 5 years old age which the success confirms by the index mortality rate of children fewer than 5 and neonatal mortality. Because neonatal mortality is approximate 50% of the mortality of children under 5, so that the newborn babies are vulnerable and need to be given special attention. - 5 - Thailand has also been working to reducing the neonatal mortality rate as the ultimate goal of Thai National Health Service Plan for newborn. Congenital Heart Defect (CHD) is a global prevailing problem, the incidence approximately 6-8/1,000 live births from over 730,000 newborns those are about 6,000 to 7,000 each year in Thailand. Among this group 1-1.5/1,000 or approximately 1,000 newborns develop CCHD, a leading cause of neonatal deaths.
Recommended publications
  • Somrat Vol. 11 No. 1 Page 21-32.Pmd
    Asian Biomedicine Vol. 11 No. 1 February 2017; 21 - 32 DOI: 10.5372/1905-7415.1101.535 Original article Perioperative and Anesthetic Adverse events in Thailand (PAAd Thai) incident reporting study: anesthetic profiles and outcomes Somrat Charuluxananan1, Wimonrat Sriraj2, Yodying Punjasawadwong3, Siriporn Pitimana-aree4, Varinee Lekprasert5, Thewarug Werawatganon1, Wirat Wasinwong6, Prapa Ratanachai7, Dujduen Sriramatr8, Sunida Atichat9, Wanna Angkasuvan7, Chuthamat Somchat10, Duangporn Tanutanud11, Thidarat Ariyanuchitkul12, Jaroonpong Choorat13, Krairerk Sintavanuruk14, Jeratkana Janngam15 1Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand 2Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand 3Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand 4Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand 5Department of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand 6Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand 7Department of Anesthesiology, Hatyai Hospital, Songkhla 90110, Thailand 8Department of Anesthesiology, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok 26120, Thailand 9Department of Anesthesiology, Chonburi Regional Hospital, Chonburi 20000, Thailand 10Department of Anesthesiology, Lamphun Hospital, Lamphun
    [Show full text]
  • HIS in Thailand Never Ending Stories Thai Health Information System: of the Development of an Effective Situation and Challenges HIS in Thailand Dr
    Never ending stories of the development of an effective HIS in Thailand Never ending stories Thai Health Information System: of the development of an effective Situation and challenges HIS in Thailand Dr. Pinij Faramnuayphal Supported by : Prince Mahidol Award Foundation under the Royal Patronage Ministry of Public Health World Health Organization The World Health Organization (WHO) identifies fully functional health Mahidol University information system as one of the six important building blocks of high Health Systems Research Institute performing health system. A well-functioning health information system (HIS) is one that ensures the production, analysis, dissemination and Published by: use of reliable and timely information on health determinants, health system performance and health status. All of these components Health Systems Research Institute (HSRI) contribute to a better health policy and planning, health resources allocation, health service delivery and finally, health outcome. With the cooperation of : The importance of health information system is crucial and is Ang Thong Provincial Health Office recognized that countries cannot build a good health system without Bangkok Hospital Group Medical Center it. Strengthening health information system, therefore, has become Bang Phae Hospital one of the most important issues worldwide in a recent decade. Bumrungrad Hospital Public Company Limited The demand on measuring the Millennium Development Goals is National Health Security office an example of the explicit requirements of
    [Show full text]
  • Certification of Quality Management System for Medical Laboratories Complying with Medical Laboratory Standard, Ministry of Public Health
    Department of Medical Sciences F0715102 Ministry of Public Health Certification of quality management system for medical laboratories complying with Medical Laboratory Standard, Ministry of Public Health Information date on 1 March 2019 new = initial accreditation, r1 = reassessment 1 , TS = Temporary Suspension, P = Process No. HCode Health RMSc Status Medical Laboratory Province Registration Accredited Expiration Region No. Date Date 1 10673 2 2 r1 Uttaradit Hospital Uttaradit 0001/2557 07/08/2017 06/08/2020 2 11159 2 2 r1 Tha Pla Hospital Uttaradit 0002/2557 07/08/2017 06/08/2020 3 11160 2 2 r1 Nam Pat Hospital Uttaradit 0003/2557 07/08/2017 06/08/2020 4 11161 2 2 r1 Fak Tha Hospital Uttaradit 0004/2557 07/08/2017 06/08/2020 5 11162 2 2 r1 Ban Khok Hospital Uttaradit 0005/2557 07/08/2017 06/08/2020 6 11163 2 2 r1 Phichai Hospital Uttaradit 0006/2557 07/08/2017 06/08/2020 7 11164 2 2 r1 Laplae Hospital Uttaradit 0007/2557 07/08/2017 06/08/2020 8 11165 2 2 r1 ThongSaenKhan Hospital Uttaradit 0008/2557 07/08/2017 06/08/2020 9 11158 2 2 r1 Tron Hospital Uttaradit 0009/2557 07/08/2017 06/08/2020 10 10863 4 4 r1 Pak Phli Hospital Nakhonnayok 0010/2557 07/08/2017 06/08/2020 11 10762 4 4 r1 Thanyaburi Hospital Pathum Thani 0011/2557 07/08/2017 06/08/2020 12 10761 4 4 r1 Klong Luang Hospital Pathum Thani 0012/2557 07/08/2017 06/08/2020 13 11141 1 1 P Ban Hong Hospital LamPhun 0014/2557 07/08/2014 06/08/2017 14 11142 1 1 P Li Hospital LamPhun 0015/2557 07/08/2014 06/08/2017 15 11144 1 1 P Pa Sang Hospital LamPhun 0016/2557 07/08/2014 06/08/2017
    [Show full text]
  • Bangkok Anesthesia Regional Training Center
    RoleRole ofof BARTCBARTC (Bangkok(Bangkok AnesthesiaAnesthesia RegionalRegional TrainingTraining Center)Center) IInn cooperationcooperation inin educationeducation andand trainingtraining inin developingdeveloping countriescountries ProfProf TharaThara TritrakarnTritrakarn DirectorDirector ofof BARTCBARTC 14th WCA, Cape Town, South Africa, 3/1/2008 Oslo Center, Norway, 12/1/2008 ShortageShortage ofof anesthesiologistsanesthesiologists AA worldwideworldwide problemsproblems MoreMore seriousserious inin developingdeveloping poorpoor countriescountries MarkedMarked variationvariation amongamong countriescountries EconomyEconomy - Most important determining factors - Three levels of wealth & health - Rich countries (per capita GNP > $ 10,000) - Medium to low (GNP $ 1,000-10,000) - Poor countries (GNP < $ 1,000) RichRich && MediumMedium countriescountries GNPGNP PeoplePeople NumberNumber PeoplePeople perper capitacapita perper ofof perper (US(US $)$) doctordoctor anesthetistsanesthetists anesthetistanesthetist USA 33,799 387 23,300 11,500 Japan 34,715 522 4,229 20,000 Singapore 22,710 667 150 26,600 Hong Kong 23,597 772 150 40,000 Australia 19,313 2170 10,000 Malaysia 3,248 1,477 250 88,000 Thailand 1,949 2,461 500 124,000 Philippines 1,048 1,016 1176 64,600 MediumMedium && PoorPoor CountriesCountries GNPGNP PeoplePeople NumberNumber PeoplePeople perper capitacapita perper ofof perper (US(US $)$) doctordoctor anesthetistsanesthetists anesthetistanesthetist Indonesia 617 6,7866,786 350 591,000591,000 Pakistan 492 2,0002,000 400 340,000340,000
    [Show full text]
  • Cover Tjs 35-4-57
    ISSN 0125-6068 TheThai Journal of SURGERY Official Publication of the Royal College of Surgeons of Thailand www.surgeons.or.th/ejournal Volume 35 October-December 2014 Number 4 ORIGINAL ARTICLES 121 Comparison between Ventriculoatrial Shunt and Ventriculoperitoneal Shunt: Revision Rate and Complications Korrapakc Wangtanaphat, Porn Narischart 126 Open Surgical Management of Atherosclerotic Aortoiliac Occlusive Diseases (AIOD) Type 1 Anuwat Chantip 130 “Sawanpracharak” Connector: A Single Tube Intercostal Drainage Connector Wanchai Manakijsirisuthi 134 The Trainee’s Operative Experiences for General Surgery in Thailand Potchavit Aphinives CASE REPORT 139 Mitral and Tricuspid Valve Replacement in Uncommon Case of Situs Inversus with Dextrocardia Nuttapon Arayawudhikul, Boonsap Sakboon, Jareon Cheewinmethasiri, Angsu Chartirungsun, Benjamaporn Sripisuttrakul ABSTRACTS 143 Abstracts of the 39th Annual Scientific Congress of the Royal College of Surgeons of Thailand, 10-13 July 2014, Ambassador City Jomtien Hotel, Jomtien, Pattaya, Cholburi, Thailand (Part II) 169 Index Secretariat Office : Royal Golden Jubilee Building, 2 Soi Soonvijai, New Petchaburi Road, Huaykwang, Bangkok 10310, Thailand Tel. +66 2716 6141-3 Fax +66 2716 6144 E-mail: [email protected] www.surgeons.or.th The THAI Journal of SURGERY Official Publication of the Royal College of Surgeons of Thailand Vol. 35 October - December 2014 No. 4 Original Article Comparison between Ventriculoatrial Shunt and Ventriculoperitoneal Shunt: Revision Rate and Complications Korrapakc Wangtanaphat, MD Porn Narischart, MD Prasat Neurological Institute, Department of Medical Services, Ministry of Pubic Health, Bangkok, Thailand Abstract Background and Objective: Hydrocephalus is a common problem in neurosurgical field. In current clinical practice guidelines, ventriculoatrial shunt and ventriculoperitoneal shunt are recommended treatment options. No previous study reported differences between two procedures in term of complications and revision rates.
    [Show full text]
  • January 08-11 Pp01
    ANDAMAN Edition Volume 18 Issue 2 January 8 - 14, 2011 Daily news at www.phuketgazette.net 25 Baht Booze ban hits park tourists Teen stabbing sparks alcohol ban in national parks By Atchaa Khamlo derstand and have given us very Standard procedure is for staff good co-operation. The situation to ask people trying to bring alco- THE directors of several national is under control,” he said. hol into the park to leave it with parks in the Andaman region say Most of those warned about officers during their visit, he said. they have received good compli- drinking in the park were Thais, “We prefer to ask people for ance with the ban on alcohol in- but a few were foreigners. their co-operation rather than side parks that came into effect “As the park is quite expansive, threaten them with punishment. It on December 27. sometimes people might be drink- seems our public relations cam- Natural Resources and Envi- ing inside without our being aware paign is going well, as most people ronment Minister Suwit Khunkitti of it,” he added. just drink Coke or water,” he said. issued the ban immediately follow- Two signs declaring the park “Most foreigners understand ing the December 26 stabbing an alcohol prohibition zone are quite well. Not many of them drink murder of a student by a group of now being constructed and should whiskey, but some like to drink drunken schoolmates camping at go up at both entrances very soon, beer. But they don’t seem to have Khao Yai National Park in Surat along with a third sign to go up in any problem with alcohol being Thani.
    [Show full text]
  • Economic Burden of Hospitalization with Acute Wheezing in Preschool Children: a Multi-Center Study
    Economic Burden of Hospitalization with Acute Wheezing in Preschool Children: A Multi-Center Study Paskorn Sritipsukho MD*,**, Khlongtip Matchimmadamrong MD***, Sasawan Chinratanapisit MD****, Jitladda Deerojanawong MD***** * Center of Excellence in Applied Epidemiology, Thammasat University, Pathumthani, Thailand ** Division of Allergy, Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, Thailand *** Department of Pediatrics, Saraburi Hospital, Saraburi, Thailand **** Department of Pediatrics, Bhumibol Adulyadej Hospital, Bangkok, Thailand ***** Division of Respiratory disease and intensive care, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Background: Wheezing is an important health problem in Thailand especially among preschool age. Objective: The aim of this study was to estimate costs of wheezing for hospitalization in preschool children under patient, provider, and societal perspectives. Material and Method: Two hundred and thirty-four participants who were admitted with acute wheezing at 4 hospitals including Thammasat University Hospital, Saraburi Hospital, Bhumibol Adulyadej Hospital and King Chulalongkorn Memorial Hospital during July 2014 to June 2015 were included in the present study. Data from hospital financial database and caregivers’ expenses were collected. Cost-to-charge ratio method was employed for valuation of direct medical costs. Informal care costs were determined by human capital approach. Results: The means of patient, provider and societal costs per admission were 3,020 THB (SD = 6,632 THB), 18,126 THB (SD = 16,898 THB), and 20,269 THB (SD = 20,537 THB) respectively. The main cost component in provider and societal perspective were accommodation costs during admission. Informal care cost was a major cost component for direct non- medical costs. The economic burden of acute wheezing admission of preschool children in Thailand was estimated as 759 million THB per year.
    [Show full text]
  • Resistance Patterns Selected by Nevirapine Vs
    Resistance Patterns Selected by Nevirapine vs. Efavirenz in HIV-Infected Patients Failing First-Line Antiretroviral Treatment: A Bayesian Analysis Nicole Ngo-Giang-Huong1,2,3*, Gonzague Jourdain1,2,3, Billy Amzal1,2, Pensiriwan Sang-a-gad4, Rittha Lertkoonalak5, Naree Eiamsirikit6, Somboon Tansuphasawasdikul7, Yuwadee Buranawanitchakorn8, Naruepon Yutthakasemsunt9, Sripetcharat Mekviwattanawong10, Kenneth McIntosh3,11, Marc Lallemant1,2,3, for the Program for HIV Prevention and Treatment (PHPT) study group" 1 Institut de Recherche pour le De´veloppement (IRD) UMI 174 - PHPT, Marseilles, France, 2 Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, 3 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, 4 Ratchaburi Hospital, Ratchaburi, Thailand, 5 Maharat Nakonratchasima Hospital, Nakonratchasima, Thailand, 6 Samutprakarn Hospital, Samutprakarn, Thailand, 7 Buddhachinaraj Hospital, Pitsanuloke, Thailand, 8 Chiang Kham Hospital, Chiang Kham, Thailand, 9 Nong Khai Hospital, Nong Khai, Thailand, 10 Pranangklao Hospital, Bangkok, Thailand, 11 Division of Infectious Diseases, Children’s Hospital, Boston, Massachusetts, United States of America Abstract Background: WHO recommends starting therapy with a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs), i.e. nevirapine or efavirenz, with lamivudine or emtricitabine, plus zidovudine or
    [Show full text]
  • วารสาร พยาบาลสาร Nursing Journal ปีที่ 47 ฉบับที่ 1 มกราคม-มีนาคม พ.ศ
    พยาบาลสาร : Nursing Journal คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ วารสาร พยาบาลสาร Nursing Journal ปีที่ 47 ฉบับที่ 1 มกราคม-มีนาคม พ.ศ. 2563 • Volume 47 No.1 January-March 2020 ISSN 0125-5118 ที่ปรึกษา (Consultant) ศาสตราจารย์ ดร.วิภาดา คุณาวิกติกุล คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Wipada Kunaviktikul, PhD, RN, FAAN Faculty of Nursing, Chiang Mai University ผู้ช่วยศาสตราจารย์ ดร.จุฑารัตน์ มีสุขโข คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Jutarat Mesukko, PhD, RN Faculty of Nursing, Chiang Mai University ที่ปรึกษากองบรรณาธิการ (Editorial Advisors) ศาสตราจารย์เกียรติคุณ ดร.วิจิตร ศรีสุพรรณ อดีตนายกสภาการพยาบาล Wichit Srisuphan, DrPH, RN Professor ศาสตราจารย์ ดร.ประนอม โอทกานนท์ ศาสตราจารย์ Pranom Othagnont, RN, M.E.D.,Ed.D. Professor ศาสตราจารย์ ดร.สมจิต หนุเจริญกุล ศาสตราจารย์ Somchit Hanucharurnkul, PhD, RN Professo บรรณาธิการ (Editor) ศาสตราจารย์ ดร. อารีวรรณ กลั่นกลิ่น คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Areewan Klunklin, PhD, RN Faculty of Nursing, Chiang Mai University รองบรรณาธิการ (Associate Editor) รองศาสตราจารย์ ดร.นันทพร แสนศิริพันธ์ คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Nantaporn Sansiriphun, PhD, RN, APN Faculty of Nursing, Chiang Mai University กองบรรณาธิการ (Editorial Board) ศาสตราจารย์ ดร.รุจา ภู่ไพบูลย์ คณะพยาบาลศาสตร์ มหาวิทยาลัยมหิดลศาสตราจารย์ Rutja Phuphaibul, DNS, RN Faculty of Nursing, Mahidol University ศาสตราจารย์ ดร.วีณา จีระแพทย์ คณะพยาบาลศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย Veena Jirapaet, PhD, RN Faculty of Nursing, Chulalongkorn University ศาสตราจารย์ ดร.วารุณี ฟองแก้ว คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Warunee Fongkaew,
    [Show full text]
  • Blood Group Genomics
    BLOOD GROUP GENOMICS Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of 36 blood group alleles among 396 Thai samples reveals region-specific variants Philaiphon Jongruamklang,1 Christoph Gassner,2 Stefan Meyer,2 Aksarakorn Kummasook,3 Marion Darlison,1 Chayanun Boonlum,4 Surin Chanta,5 Beat M. Frey,2 Martin L. Olsson,1,6* and Jill R. Storry 1,6* lood group antigen polymorphism shows great BACKGROUND: Blood group phenotype variation has variation in different world populations. The been attributed to potential resistance to pathogen reason for this is not completely understood; invasion. Variation was mapped in blood donors from however, it has been attributed to both Lampang (northern region) and Saraburi (central region), B Thailand, where malaria is endemic. The previously unknown blood group allele profiles were characterized ABBREVIATIONS: MALDI-TOF MS 5 matrix-assisted laser and the data were correlated with phenotypes. The high desorption/ionization time-of-flight mass spectrometry; PCR- incidence of the Vel-negative phenotype previously ASP 5 polymerase chain reaction with allele-specific reported in Thais was investigated. primers; SNP(s) 5 single nucleotide polymorphism(s). STUDY DESIGN AND METHODS: DNA from 396 From 1Hematology and Transfusion Medicine, Department of blood donors was analyzed by matrix-assisted laser Laboratory Medicine, Lund University, Lund, Sweden; desorption/ionization–time-of-flight mass spectrometry. 2Molecular Diagnostics & Research (MOC), Blood Transfusion Outliers were investigated by serology and DNA Service Zurich,€ Zurich-Schlieren,€ Switzerland; 3Department of sequencing. Allele discrimination assays for SMIM1 Medical Technology, School of Allied Health Sciences, rs1175550A/G and ACKR1 rs118062001C/T were University of Phayao, Phayao, Thailand; 4Transfusion Medicine, performed and correlated with antigen expression.
    [Show full text]
  • Aw-Poster-Pongsak Pirom-0629
    Poster #0629 HEPATITIS B VIRUS DNA LEVEL CHANGES IN HBeAg+ PREGNANT WOMEN RECEIVING TDF FOR PREVENTION OF MOTHER-TO-CHILD TRANSMISSION IRD-CMU PHPT CROIConference on Retroviruses Nicole Ngo-Giang-Huong1, Nicolas Salvadori2, Woottichai Khamduang2, Tim R. Cressey2, Linda J. Harrison3, Luc Decker1, Camlin Tierney3, Jullapong Achalapong4, and Opportunistic Infections Trudy V. Murphy5, Noele Nelson5, George K. Siberry6, Raymond T. Chung7, Stanislas Pol8, Gonzague Jourdain1, for the iTAP study group 1IRD, Chiang Mai, Thailand, 2Chiang Mai University, Chiang Mai, Thailand, 3Harvard University, Boston, MA, USA, 4Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, 5CDC, Atlanta, GA, USA, 6USAID, Arlington, VA, USA, 7Massachusetts General Hospital, Boston, MA, USA, 8Cochin Hospital, Paris, France Background HBV DNA load measurements • 12% (19 of 161) did not achieve 5.3 log10 IU/ml at delivery; References • Population: all women assigned to the TDF arm + a randomly the median (range) HBV DNA for these women was 8.3 • High hepatitis B virus (HBV) DNA levels and positive hepatitis (7.1 to 9.1) log IU/mL at baseline, 7.4 (4.7 to 8.6) at • Sarin SK, Kumar M, Lau GK, et al. Asian-Pacific clinical practice guidelines on selected subset of 50 women assigned to the placebo arm 10 B e antigen (HBeAg-an indicator of rapid viral replication and 32-weeks, 7.0 (3.9 to 8.5) at 36 weeks and 7.8 (5.3 to 8.9) the management of hepatitis B: a 2015 update. Hepatol Int 2016;10:1-98. • European Association for the Study of the Liver. Electronic address eee, high level of HBV DNA) are the main markers of risk for • Timing: at baseline (28 weeks gestation), at Weeks 32 and at delivery.
    [Show full text]
  • Clinical Epidemiology of 7126 Melioidosis Patients in Thailand and the Implications for a National Notifiable Diseases Surveilla
    applyparastyle “fig//caption/p[1]” parastyle “FigCapt” View metadata, citation and similar papers at core.ac.uk brought to you by CORE Open Forum Infectious Diseases provided by Apollo MAJOR ARTICLE Clinical Epidemiology of 7126 Melioidosis Patients in Thailand and the Implications for a National Notifiable Diseases Surveillance System Viriya Hantrakun,1, Somkid Kongyu,2 Preeyarach Klaytong,1 Sittikorn Rongsumlee,1 Nicholas P. J. Day,1,3 Sharon J. Peacock,4 Soawapak Hinjoy,2,5 and Direk Limmathurotsakul1,3,6, 1Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 2 Epidemiology Division, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand, 3 Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford, Oxford, United Kingdom, 4 Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 5 Office of International Cooperation, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand, and 6 Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Background. National notifiable diseases surveillance system (NNDSS) data in developing countries are usually incomplete, yet the total number of fatal cases reported is commonly used in national priority-setting. Melioidosis, an infectious disease caused by Burkholderia pseudomallei, is largely underrecognized by policy-makers due to the underreporting of fatal cases via the NNDSS. Methods. Collaborating with the Epidemiology Division (ED), Ministry of Public Health (MoPH), we conducted a retrospec- tive study to determine the incidence and mortality of melioidosis cases already identified by clinical microbiology laboratories nationwide. A case of melioidosis was defined as a patient with any clinical specimen culture positive for B.
    [Show full text]