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2-Phenoxyethanol

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2-Phenoxyethanol 2-Phenoxyethanol sc-238193 Material Safety Data Sheet Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME 2-Phenoxyethanol STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH3 HAZARD INSTABILITY0 SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY: ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS C8-H10-O2, Arosol, "Dowanol EP", "Emeressence 1160", "Emery 6705", "ethylene glycol monophenyl ether", 2-fenoxyethanol, fenyl- cellosolve, "glycol monophenyl ether", "beta-hydroxyethyl phenyl ether", 1-hydroxy-2-phenoxyethane, "phenoxy ethanol", phenoxyethanol, 2-phenoxyethanol, "phenoxyethyl alcohol", phenoxetol, phenoxytol, "phenyl cellosolve", "phenylmonoglycol ether", "rose ether", "ethylene phenoxtol", "fish anaesthetic", "embalming aid" Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 2 Body Contact: 2 Min/Nil=0 Low=1 Reactivity: 2 Moderate=2 High=3 Chronic: 2 Extreme=4 CANADIAN WHMIS SYMBOLS 1 of 11 EMERGENCY OVERVIEW RISK Harmful if swallowed. Irritating to eyes. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. ! At sufficiently high doses the material may be neurotoxic(i. e. EYE ! There is evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Severe inflammation may be expected with pain. SKIN ! Skin contact with the material may damage the health of the individual; systemic effects may result following absorption. ! There is some evidence to suggest that the material may cause mild but significant inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering. ! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. ! Repeated skin exposure to ethylene glycol phenyl ether may result in absorption of harmful amounts. Immediate symptoms may include, headache, lightheadedness, and a general feeling of intoxication. INHALED ! The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. ! Inhalation hazard is increased at higher temperatures. ! Not normally a hazard due to non-volatile nature of product. CHRONIC HEALTH EFFECTS ! Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Exposure to the material may cause concerns for human fertility, on the basis that similar materials provide some evidence of impaired fertility in the absence of toxic effects, or evidence of impaired fertility occurring at around the same dose levels as other toxic effects, but which are not a secondary non-specific consequence of other toxic effects. Ethylene glycol esters and their ethers cause wasting of the testicles, reproductive changes, infertility and changes to kidney function. Shorter chain compounds are more dangerous. Case studies indicate that ethylene glycol phenyl ether (EGPE), is responsible for acute neurotoxic effects as well as chronic solvent- induced brain syndrome with repeated exposure. Constant irritability, impaired memory and depression may occur after 1-2 yr occupational exposure to EGPE. Other symptoms include alcohol intolerance, episodes of tachycardia and dyspnea, problems with balance and rash. Woman fish hatchery workers, constantly exposed to EGPE, underwent neurophysiological testing and were found to have persistent focal cognitive impairment. [Yearbook of Occupational & Environmental Medicine 1991] Excessive exposure may cause haemolysis, thereby impairing the ability of blood to transport oxygen. Congeners are expected to exhibit similar behaviour. Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS NAME CAS RN % ethylene glycol phenyl ether 122-99-6 >98 NOTE: Product may contain residual reactant as ethylene oxide 75-21-8 2 of 11 Section 4 - FIRST AID MEASURES SWALLOWED · IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. · Where Medical attention is not immediately available or where the patient is more than 15 minutes from a hospital or unless instructed otherwise: EYE ! If this product comes in contact with the eyes: · Wash out immediately with fresh running water. · Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. SKIN ! If skin contact occurs: · Immediately remove all contaminated clothing, including footwear · Flush skin and hair with running water (and soap if available). INHALED · If fumes or combustion products are inhaled remove from contaminated area. · Other measures are usually unnecessary. NOTES TO PHYSICIAN ! for poisons (where specific treatment regime is absent): ----------------------------------------------------------------------------------------------------------------BASIC TREATMENT ---------------------------------------------------------------------------------------------------------------- · Establish a patent airway with suction where necessary. · Watch for signs of respiratory insufficiency and assist ventilation as necessary. Treat symptomatically. Section 5 - FIRE FIGHTING MEASURES Vapour Pressure (mmHG): Not Available Upper Explosive Limit (%): Not available. Specific Gravity (water=1): 1.1 Lower Explosive Limit (%): Not available. EXTINGUISHING MEDIA · Water spray or fog. · Foam. FIRE FIGHTING · Alert Emergency Responders and tell them location and nature of hazard. · Wear full body protective clothing with breathing apparatus. GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS · Combustible. · Slight fire hazard when exposed to heat or flame. Combustion products include: carbon dioxide (CO2), other pyrolysis products typical of burning organic material. May emit poisonous fumes. May emit corrosive fumes. FIRE INCOMPATIBILITY ! Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids,chlorine bleaches, pool chlorine etc. as ignition may result. PERSONAL PROTECTION Glasses: Chemical goggles. Gloves: Respirator: Type AX-P Filter of sufficient capacity Section 6 - ACCIDENTAL RELEASE MEASURES MINOR SPILLS · Remove all ignition sources. · Clean up all spills immediately. MAJOR SPILLS ! Moderate hazard. · Clear area of personnel and move upwind. · Alert Emergency Responders and tell them location and nature of hazard. Section 7 - HANDLING AND STORAGE 3 of 11 PROCEDURE FOR HANDLING · DO NOT allow clothing wet with material to stay in contact with skin. The substance accumulates peroxides which may become hazardous only if it evaporates or is distilled or otherwise treated to concentrate the peroxides. The substance may concentrate around the container opening for example. Purchases of peroxidisable chemicals should be restricted to ensure that the chemical is used completely before it can become peroxidised. · A responsible person should maintain an inventory of peroxidisable chemicals or annotate the general chemical inventory to indicate which chemicals are subject to peroxidation. An expiration date should be determined. The chemical should either be treated to remove peroxides or disposed of before this date. · The person or laboratory receiving the chemical should record a receipt date on the bottle. The individual opening the container should add an opening date. · Unopened containers received from the supplier should be safe to store for 18 months. · Opened containers should not be stored for more than 12 months. · Avoid all personal contact, including inhalation. · Wear protective clothing when risk of exposure occurs. RECOMMENDED STORAGE METHODS · Metal can or drum · Packing as recommended by manufacturer. STORAGE REQUIREMENTS · Store in original containers. · Keep containers securely sealed. · No smoking, naked lights or ignition sources. · Store in a cool, dry, well-ventilated area. · Store away from incompatible materials and foodstuff containers. · Protect containers against physical damage and check regularly for leaks. · Observe manufacturer's storing and handling recommendations. Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION EXPOSURE CONTROLS TWA TWA STEL STEL Peak Peak TWA Source Material Notes ppm mg/m! ppm mg/m! ppm mg/m! F/CC ___________ ___________ _______ _______ _______ _______ _______ _______ _______ _______ Canada - ethylene glycol Ontario phenyl ether 25 141 Skin / Peau Occupational (2-Phenoxyethanol / Exposure Limits Phénoxyéthanol) Canada - Alberta ethylene oxide 1 1.8 Occupational (Ethylene oxide) Exposure Limits Canada - British Columbia
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