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W O 201 1/094579 A2
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau „ (10) International Publication Number (43) International Publication Date 4 August 2011 (04.08 .2011) W O 201 1/094579 A2 (51) International Patent Classification: (74) Agent: NATH, Gary, M., et al. a ; The Nath Law Group, A61K 36/06 (2006.01) A61P 29/00 (2006.01) 112 S. West Street, Alexandria, Virginia 22314 (US). A61P 3/10 (2006.01) A61P 11/00 (2006.01) (81) Designated States (unless otherwise indicated, for every A61P 19/02 (2006.01) A61P 17/06 (2006.01) kind of national protection available): AE, AG, AL, AM, A61P 1/16 (2006.01) A61P 25/16 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, A61P 9/10' (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US201 1/022976 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (22) International Filing Date: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 28 January 201 1 (28.01 .201 1) NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (25) Filing Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 61/282,376 29 January 2010 (29.01 .2010) US GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, (71) Applicants (for all designated States except US): NEW ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, CHAPTER INC. -
C3gc42589d1.Pdf
Electronic Supplementary Material (ESI) for Green Chemistry. This journal is © The Royal Society of Chemistry 2014 Supporting Information Highly Efficient, NiAu-catalyzed Hydrogenolysis of Lignin into Phenolic Chemicals Jiaguang Zhang, Hiroyuki Asakura, Jeaphianne van Rijn, Jun Yang, Paul Duchesne, Bin Zhang, Xi Chen, Peng Zhang, Mark Saeys* and Ning Yan* Contents 1 Materials ............................................................................................................................................. 3 2 Synthesis of substrates ....................................................................................................................... 3 2.1 Organosolv Lignin ......................................................................................................................... 3 2.2 2‐phenoxy‐1‐phenethanol ........................................................................................................... 3 2.3 2‐(2‐methoxyphenyl)oxy‐1‐phenethanol ..................................................................................... 4 2.4 2‐(2,6‐dimethoxyphenyl)oxy‐1‐phenethanol ............................................................................... 4 2.5 1‐benzyloxy‐2‐methoxybenzene .................................................................................................. 4 3 Catalyst preparation and reaction ...................................................................................................... 4 3.1 Catalyst preparation .................................................................................................................... -
European Patent Office of Opposition to That Patent, in Accordance with the Implementing Regulations
(19) TZZ __T (11) EP 2 416 766 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 31/045 (2006.01) A61K 45/06 (2006.01) 09.04.2014 Bulletin 2014/15 A61K 8/34 (2006.01) A61P 17/00 (2006.01) A61P 17/16 (2006.01) A61Q 19/00 (2006.01) (2006.01) (2006.01) (21) Application number: 09701247.0 A23L 1/30 A23L 2/02 A23L 2/39 (2006.01) A23C 9/13 (2006.01) A23C 11/10 (2006.01) A61Q 5/02 (2006.01) (22) Date of filing: 09.04.2009 A61Q 11/00 (2006.01) A61Q 15/00 (2006.01) A61Q 17/04 (2006.01) A61Q 19/02 (2006.01) A61K 8/02 (2006.01) A61Q 19/04 (2006.01) (86) International application number: PCT/EP2009/054336 (87) International publication number: WO 2009/087242 (16.07.2009 Gazette 2009/29) (54) COMPOSITIONS COMPRISING TRANS-TERT-BUTYL CYCLOHEXANOL AS SKIN IRRITATION- REDUCING AGENT ZUSAMMENSETZUNGEN MIT TRANS-TERT-BUTYL-CYCLOHEXANOL ALS MITTEL ZUR REDUZIERUNG VON HAUTREIZUNGEN COMPOSITIONS COMPRENANT DU TRANS-TERT-BUTYL CYCLOHEXANOL EN TANT QU’AGENT RÉDUISANT L’IRRITATION CUTANÉE (84) Designated Contracting States: • KROHN, Michael AT BE BG CH CY CZ DE DK EE ES FI FR GB GR 64653 Lorsch (DE) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL • ZINKE, Holger PT RO SE SI SK TR 64646 Heppenheim (DE) (43) Date of publication of application: (74) Representative: Eisenführ Speiser 15.02.2012 Bulletin 2012/07 Patentanwälte Rechtsanwälte PartGmbB Postfach 10 60 78 (73) Proprietor: Symrise AG 28060 Bremen (DE) 37603 Holzminden (DE) (56) References cited: (72) Inventors: EP-A2- 0 755 910 WO-A1-97/22332 • VIELHABER, Gabriele WO-A1-2008/117254 US-A- 2 927 127 75008 Paris (FR) • OERTLING, Heiko • SYMRISE GMBH & CO KG ET AL: "Trans-tert- 1012 Lausanne (CH) butyl cyclohexanol as skin irritation-reducing • GÖMANN, Claudia agent" RESEARCH DISCLOSURE, MASON 37640 Warbsen (DE) PUBLICATIONS, HAMPSHIRE, GB, vol. -
Supplements with Anti-Cancer Activity
COMPLEMENTARY THERAPIES FOR PETS WITH CANCER The approach to helping pets that have been diagnosed with cancer goes beyond surgery, chemotherapy or radiation, and palliative care. There are a number of other options to support and treat pets with cancer, which can be used in conjunction with the conventional methods, or which be employed on their own. The goals are generally to slow or stop the progression of cancer, and provide the pet the best quality of life possible for the longest period of time. In order to do this, the steps are: 1) Provide the best diet possible (return to the Kali’s Wish Info Hub for more diet info). 2) Supply specific nutrients and supplements that are the best combination to strengthen the pet’s immune system and support the whole body. 3) Provide supplements and nutraceuticals to slow or stop the cancer. 4) Make lifestyle changes that will help support the pet’s health. Supplements with Anti-Cancer Activity There is ever increasing research into supplements and nutraceuticals (purified extracts usually from plants) that have anti-cancer activity. The mechanisms by which most supplements work against cancer are: 1) Inducing apoptosis - causing the cancer cell to break apart and die; occurs by various mechanisms. 2) Anti-angiogenesis—blocks the formation of blood vessels in the tumour, so that it can’t receive nutrients and oxygen, and can’t grow easily. 3) Pro-angiogenesis—supports formation of blood vessels (sometimes useful to help penetration of herbs into the center of tumour masses, and can increase oxygen in anoxic environments). -
Kidney Function Indices in Mice After Long Intake of Agaricus Brasiliensis Mycelia (= Agaricus Blazei , Agaricus Subrufescens ) Produced by Solid State Cultivation
OnLine Journal of Biological Sciences 9 (1): 21-28, 2009 ISSN 1608-4217 © 2009 Science Publications Kidney Function Indices in Mice after Long Intake of Agaricus brasiliensis Mycelia (= Agaricus blazei , Agaricus subrufescens ) Produced by Solid State Cultivation 1,5Dalla Santa Herta Stutz, 5Rubel Rosália, 5Vitola Francisco Menino Destéfanis, 2Leifa Fan, 3Tararthuch Ana Lucia, 4Lima Filho Cavalcante José Hermênio, 4Figueiredo Bonald Cavalcante, 1Dalla Santa Osmar Roberto, 1Raymundo Melissa dos Santos, 5Habu Sasha and 5Soccol Carlos Ricardo 1Department of Food Engineering, Midwest State University, Street Simeão Camargo de Varela de Sá, 03; CEP: 85040-080, Guarapuava, Paraná, Brazil 2Institute of Horticulture, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China 3Department of Physiology, Federal University of Paraná, Jardim das Américas, CEP: 81531-990, Curitiba, Paraná,Brazil 4Department of Medical Pathology, Federal University of Paraná 5Bioprocess Engineering and Biotechnology Division, Federal University of Paraná, Jardim das Américas, Cx Postal 19031, CEP: 81531-990, Curitiba, Paraná, Brazil Abstract: Problem statement: Agaricus brasiliensis (= Agaricus blazei , Agaricus subrufescens ) or Sun mushroom has widespread use for potential health benefits such anti-tumor and immunomodulatory effects. Studies detected that others edible mushrooms affected renal metabolism and despite the widespread use of A. brasiliensis there are no studies that address biological effects on the renal function indices after their oral administration. Therefore, this study had as objective to verify the effects on kidney function indices after long intake of A. brasiliensis mycelium. Approach: Wheat grains was cultured during 18 days with Agaricus brasiliensis mycelium by solid state culture and used for chown formulation. Groups of female Swiss mice (20 per group) were fed during 14 weeks with 100 and 50% of the formulated feed denominated A100 and A50, respectively. -
Opinion of the Scientific Committee on Consumer Safety on O
SCCS/1575/16 Final version of 6 October 2016 Version S Scientific Committee on Consumer Safety SCCS OPINION ON Phenoxyethanol The SCCS adopted this opinion at its 2nd plenary meeting on 6 October 2016 SCCS/1575/16 Final version of the Opinion on Phenoxyethanol ___________________________________________________________________________________________ About the Scientific Committees Two independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. They are: the Scientific Committee on Consumer Safety (SCCS), the Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) The Scientific Committees review and evaluate relevant scientific data and assess potential risks. Each Committee has top independent scientists from all over the world who are committed to work in the public interest. In addition, the Commission relies upon the work of the European Food Safety Authority (EFSA), the European Medicines Agency (EMA), the European Centre for Disease prevention and Control (ECDC) and the European Chemicals Agency (ECHA). SCCS The Committee, on request of Commission services, provides Opinions on questions concerning health and safety risks (notably chemical, biological, mechanical and other physical risks) of non-food consumer products (e.g. cosmetic products and -
2-Phenoxyethanol
PATIENT INFORMATION SHEET 2-Phenoxyethanol (P-025) Your patch testing results indicate that you have a contact allergy to 2-Phenoxyethanol . It is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it. i What is 2-Phenoxyethanol and where is it found? This chemical is used as a fixative for perfumes, as well as a bactericide, an insect repellent, a topical antiseptic, a solvent for cellulose acetate, dyes, inks and resins. It can also be found in germicides, pharmaceuticals, cosmetics and in some preservatives. Further research may identify additional product or industrial usages of this chemical. i What else is 2-Phenoxyethanol called? This chemical can be identified by different names, including: 1‐Hydroxy ‐2‐phenoxyethane Emery 6705 Phenoxyl ethanol 2‐hydroxyethyl phenyl ether Ethanol ‐2‐phenoxy Phenoxytol Arosol Ethylene glycol phenyl ether Phenoxetol b‐Hydroxyethyl phenyl ether Ethylene glycol mono phenyl ether Phenoxyethyl alcohol Beta ‐phenoxyethyl alcohol Glycol monophenyl ether Phenylmonoglycol ether Dowanol ep, eph Phenyl cellosolve Rose ether Emeressence 1160 Phenoxethol This may not be a complete list as manufacturers introduce and delete chemicals from their product lines. THINGS YOU CAN DO TO HELP MANAGE YOUR CONTACT ALLERGY Be vigilant read the product label. Always take the time to read the ingredient listing on product packages. This should be your first step each time you purchase a product as manufacturers sometimes change product ingredients. If you have any concerns ask your pharmacist or your doctor. Test the product first. If you have purchased a new product you should test it on a small skin area to see if you get a reaction before using the product on larger skin areas. -
Compounds from Wild Mushrooms with Antitumor Potential
Compounds from Wild Mushrooms with Antitumor Potential Isabel C.F.R. Ferreira1,*, Josiana A. Vaz1,2,3,4,5, M. Helena Vasconcelos2,5 and Anabela Martins1 1CIMO-Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Sta. Apolónia, 1172, 5301-855 Bragança, Portugal. 2IPATIMUP- Institute of Molecular Pathology and Immunology of the University of Porto, Portugal. 3Escola Superior de Saúde, Ins- tituto Politécnico de Bragança, Av. D. Afonso V, 5300-121 Bragança. 4CEQUIMED-UP, Research Center of Medicinal Chemistry, University of Porto, Portugal. Laboratory of Microbiology, 5Faculty of Pharmacy, University of Porto, Portugal. Abstract: For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom prepara- tions are regarded as a tonic, that is, they have beneficial health effects without known negative side-effects and can be moderately used on a regular basis without harm. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of compounds which are modulators of tu- mour cell growth. Furthermore, they may have potential as functional foods and sources of novel molecules. We will review the com- pounds with antitumor potential identified so far in mushrooms, including low-molecular-weight (LMW, e.g. quinones, cerebrosides, isoflavones, catechols, amines, triacylglycerols, sesquiterpenes, steroids, organic germanium and selenium) and high-molecular-weight compounds (HMW, e.g. homo and heteroglucans, glycans, glycoproteins, glycopeptides, proteoglycans, proteins and RNA-protein com- plexes). -
Sustainable Sourcing : Markets for Certified Chinese
SUSTAINABLE SOURCING: MARKETS FOR CERTIFIED CHINESE MEDICINAL AND AROMATIC PLANTS In collaboration with SUSTAINABLE SOURCING: MARKETS FOR CERTIFIED CHINESE MEDICINAL AND AROMATIC PLANTS SUSTAINABLE SOURCING: MARKETS FOR CERTIFIED CHINESE MEDICINAL AND AROMATIC PLANTS Abstract for trade information services ID=43163 2016 SITC-292.4 SUS International Trade Centre (ITC) Sustainable Sourcing: Markets for Certified Chinese Medicinal and Aromatic Plants. Geneva: ITC, 2016. xvi, 141 pages (Technical paper) Doc. No. SC-2016-5.E This study on the market potential of sustainably wild-collected botanical ingredients originating from the People’s Republic of China with fair and organic certifications provides an overview of current export trade in both wild-collected and cultivated botanical, algal and fungal ingredients from China, market segments such as the fair trade and organic sectors, and the market trends for certified ingredients. It also investigates which international standards would be the most appropriate and applicable to the special case of China in consideration of its biodiversity conservation efforts in traditional wild collection communities and regions, and includes bibliographical references (pp. 139–140). Descriptors: Medicinal Plants, Spices, Certification, Organic Products, Fair Trade, China, Market Research English For further information on this technical paper, contact Mr. Alexander Kasterine ([email protected]) The International Trade Centre (ITC) is the joint agency of the World Trade Organization and the United Nations. ITC, Palais des Nations, 1211 Geneva 10, Switzerland (www.intracen.org) Suggested citation: International Trade Centre (2016). Sustainable Sourcing: Markets for Certified Chinese Medicinal and Aromatic Plants, International Trade Centre, Geneva, Switzerland. This publication has been produced with the financial assistance of the European Union. -
Preventive Effect of Food Mushrooms Against Herpetic Or
Annals of Case Reports & Reviews doi: 10.39127/2574-5747/ACRR:1000204 Research Article Donatini B, et al. Annal Cas Rep Rev: ACRR-204 Preventive Effect of Food Mushrooms Against Herpetic or SARS-Cov-2 Infections (Running title: Effect of mushrooms against viral infections) Donatini Bruno*, Le Blaye Isabelle Medecine Information Formation (Research). 40 rue du Dr Roux, 51350 Cormontreuil; France *Corresponding author: Dr Donatini Bruno, gastroenterology-hepatology, 40 rue du Dr Roux, 51350 Cormontreuil France. Tel: 06-08-58-46-29. Citation: Donatini B and Isabelle LB (2021) Preventive Effect of Food Mushrooms Against Herpetic or SARS-Cov-2 Infections. Annal Cas Rep Rev: ACRR-204. Received Date: 24 February 2021; Accepted Date: 01 Mach 2021; Published Date: 08 March 2021 Abstract Background: Some mushrooms possess strong immunostimulating properties and may prevent the occurrence of viral infections. Objective: Assess whether oral intake of food mushrooms may decrease the incidence of herpetic or SARS-COV-2 infections. Methods: Descriptive retrospective epidemiological study with data collected during routine gastroenterological consultations in patients with a high risk of viral infections and who are recommended to take mushrooms. Compliant and non-compliant groups are compared. Results: 186 patients are included. 156 patients are compliant. The long-term intake of Coriolus versicolor, Phellinus linteus, Grifola Frondosa or Ganoderma lucidum significantly decreases the global risk of viral infection (89.4% versus 13.3%; p<0.001). More specifically, this intake decreases the risk of COVID-19 (7.7% versus 13.4%; p<0.001), herpetic flares (3.2% versus 39.1%; p<0.01) and of polyps or HPV-induced lesions (0.7% versus 6.7%; p<0.001). -
Allantoin Cream Pharmicell Co., Ltd. Disclaimer
LUXURY CELL PERFORMANCE SERUM- allantoin cream Pharmicell Co., Ltd. Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies. ---------- ACTIVE INGREDIENT Active ingredient : ALLANTOIN 0.5% INACTIVE INGREDIENT Inactive ingredients : WATER, HUMAN BONE MARROW STEM CELL CONDITIONED MEDIA, GLYCERIN, DIPROPYLENE GLYCOL, HYDROGENATED POLYDECENE, NEOPENTYL GLYCOL DICAPRATE, CYCLOPENTASILOXANE, CYCLOHEXASILOXANE, CAPRYLIC/CAPRIC TRIGLYCERIDE, DIPENTAERYTHRITYL HEXA C5-9 ACID ESTERS, CETEARYL ALCOHOL, GLYCERYL STEARATE SE, HYDROGENATED LECITHIN, CITRUS PARADISI (GRAPEFRUIT) FRUIT EXTRACT, BEESWAX, POLYGONUM MULTIFLORUM ROOT EXTRACT, ARTEMISIA PRINCEPS LEAF EXTRACT, PORTULACA OLERACEA EXTRACT, PANAX GINSENG ROOT EXTRACT, ASPARAGUS COCHINCHINENSIS ROOT EXTRACT, TOCOPHERYL ACETATE, 1,2-HEXANEDIOL, PHENOXYETHANOL, XANTHAN GUM, CARBOMER, DIPOTASSIUM GLYCYRRHIZATE, ALTHAEA ROSEA ROOT EXTRACT, ALOE BARBADENSIS LEAF EXTRACT, GANODERMA LUCIDUM (MUSHROOM) EXTRACT, GRIFOLA FRONDOSA EXTRACT, INONOTUS OBLIQUUS (MUSHROOM) EXTRACT, SPARASSIS CRISPA EXTRACT, PHELLINUS LINTEUS EXTRACT , POTASSIUM HYDROXIDE, CERAMIDE 3, ADENOSINE, LAVANDULA ANGUSTIFOLIA (LAVENDER) OIL, MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL, EUCALYPTUS GLOBULUS LEAF OIL, GERANIUM MACULATUM OIL, ROSMARINUS OFFICINALIS (ROSEMARY) LEAF OIL, MENTHA PIPERITA (PEPPERMINT) OIL PURPOSE Purpose : Skin Protectant WARNINGS Warnings : Harmful if swallowed. Avoid contact with the eyes. Keep out of reach of children. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. KEEP OUT OF REACH OF CHILDREN KEEP OUT OF REACH OF CHILDREN INDICATIONS & USAGE Indication and usage : After using the eye cream, take a proper amount of the serum, and spread it outward from the inward of the face and tap the skin lightly for absorption. -
Item Name Ingredients
ITEM NAME INGREDIENTS Collagen Cream -150 Ml Aqua (Water) Cetearyl Alcohol Butylene Glycol Cetearyl Ethylhexanoate Ethylhexyl Stearate Caprylic/Capric Triglyceride Cetearyl Glucoside Soluble Collagen Phenoxyethanol Parfum (Fragrance) Chlorphenesin Polyacrylate-13 Ethylhexylglycerin Polyisobutene Benzoic Acid Hydrolyzed Soybean Fiber Dehydroacetic Acid Sodium Hydroxide Sorbitan Isostearate Polysorbate 20 Sorbic Acid CI 17200 (Red 33) Benzyl Salicylate Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde Alpha-Isomethyl Ionone Citronellol Eugenol Hyaluronic Cream-150 Ml Aqua (Water) Cetearyl Alcohol Hexyl Laurate Diethylhexylcyclohexane Di-PPG-3 Myristyl Ether Adipate Glycerin Avena Sativa (Oat) Kernel Protein Cyclopentasiloxane Cetearyl Glucoside Butyrospermum Parkii (Shea Butter) Phenoxyethanol Cyclohexasiloxane Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Palmitoyl Proline Sodium Hyaluronate Alteromonas Ferment Filtrate Magnesium Palmitoyl Glutamate Sodium Palmitoyl Sarcosinate Parfum (Fragrance) Chlorphenesin Squalane Butylene Glycol Isohexadecane Polysorbate 60 Ethylhexylglycerin Sodium Hydroxide Benzoic Acid Hydroxypropyl Cyclodextrin Dehydroacetic Acid Sorbitan Isostearate Palmitoyl Tripeptide-38 BHT Hexyl Cinnamal Linalool Alpha-Isomethyl Ionon Limonene Hydroxycitronellal Hydroxyisohexyl 3- Cyclohexene Carboxaldehyde Citronellol Silicium Cream -150 Ml Aqua (Water) Glycerin Propanediol Simmondsia Chinensis (Jojoba) Seed Oil Pentaerythrityl Tetraethylhexanoate Glyceryl Stearate Cocoglycerides Dicaprylyl Carbonate Butyrospermum