DT-MRI Inspection and

Gordon Kindlmann

Scientific Computing and Imaging Institute, School of Computing,

Gordon Kindlmann PhD (finishing) Computer Science, University of Utah

Interested in methods for looking at DT-MRI data and visually communicating its structure

Idea: two aspects of whats called visualization • Acquisition: get the data • Inspection: Show me the data verify data integrity, coordinates, and layout • Visualization: Show me the structures depict the form and character of features in the data • Analysis: extract and quantify features Scientific Computing and Imaging Institute, University of Utah z v1

x y

R=| v1.x | G=| v1.y | B=| v1.z |

st Fractional anisotropy (FA) RGB(1 eigenvector v1)

Scientific Computing and Imaging Institute, University of Utah

Backdrop: FA

Color: RGB(v1)

1 glyph = 1 mm3

Scientific Computing and Imaging Institute, University of Utah Scientific Computing and Imaging Institute, University of Utah

Scientific Computing and Imaging Institute, University of Utah Scientific Computing and Imaging Institute, University of Utah

Scientific Computing and Imaging Institute, University of Utah Scientific Computing and Imaging Institute, University of Utah

Scientific Computing and Imaging Institute, University of Utah Gordon Kindlmann PhD (finishing) Computer Science, University of Utah

Interested in methods for looking at DT-MRI data and visually communicating its structure

Idea: two aspects of whats called visualization • Acquisition: get the data • Inspection: Show me the data verify data integrity, coordinates, and layout • Visualization: Show me the structures depict the form and character of features in the data • Analysis: extract and quantify features Scientific Computing and Imaging Institute, University of Utah

Inspection saves the day

Sagittal slice: cingulum bundle, corpus callosum

Scientific Computing and Imaging Institute, University of Utah Inspection saves the day

Sagittal slice: cingulum bundle, corpus callosum

Scientific Computing and Imaging Institute, University of Utah

Inspection + Visualization Scalar shape metrics (anisotropy) • Barycentric shape space Glyphs • Boxes, spheres, cylinders, superquads • Culling based on anisotropy • Volume visualization • Isosurfaces of shape metrics • Transfer functions of shape

Scientific Computing and Imaging Institute, University of Utah Space of tensor shape v3 λ3 λ1 + λ2 + λ3 = T

λ 3 λ1 = λ2 = λ3 λ2 v 1 λ1 v2 λ2

λ1 λ >= λ >= λ spherical 1 2 3

linear planar

Scientific Computing and Imaging Institute, University of Utah

Scalar shape metrics

Westin, 1997

cs

cl cl cp

Scientific Computing and Imaging Institute, University of Utah Scalar shape metrics

Basser + Pierpaoli, 1996

1 - VR 1 - volume ratio

FA RA fractional anisotropy relative anisotropy

Scientific Computing and Imaging Institute, University of Utah

Glyph shapes

Scientific Computing and Imaging Institute, University of Utah Culling

FA = 0.10

Scientific Computing and Imaging Institute, University of Utah

Culling

FA = 0.15

Scientific Computing and Imaging Institute, University of Utah Culling

FA = 0.20

Scientific Computing and Imaging Institute, University of Utah

Culling

FA = 0.25

Scientific Computing and Imaging Institute, University of Utah Culling

FA = 0.30

Scientific Computing and Imaging Institute, University of Utah

Culling

FA = 0.35

Scientific Computing and Imaging Institute, University of Utah Culling

FA = 0.40

Scientific Computing and Imaging Institute, University of Utah

Culling

FA = 0.45

Scientific Computing and Imaging Institute, University of Utah Culling

FA = 0.50

Scientific Computing and Imaging Institute, University of Utah

Culling

FA = 0.55

Scientific Computing and Imaging Institute, University of Utah Volume Rendering Simple algorithm • Cast rays through volume • Measure tensor, tensor properties • Assign colors and opacities • Composite

DT ⇒ FA, cl, cp Transfer function R, G, B, α

Scientific Computing and Imaging Institute, University of Utah

Volume Rendering

Scientific Computing and Imaging Institute, University of Utah Volume Rendering

Scientific Computing and Imaging Institute, University of Utah

Volume Rendering

Scientific Computing and Imaging Institute, University of Utah