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Modified Amino Acids Data Sheet

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Modified Amino Acids Data Sheet Data Sheet Modified Amino Acids Innovative chemicals for process intensification in cell culture media Sulfo-Cysteine Sodium Salt Emprove® EXPERT Modified amino acids are in-house manufactured amino Product Information acid derivatives with specific properties enabling the Chemical Name L-Cysteine S-sulfate Sodium Salt intensification of cell culture processes. sesquihydrate Together with the companion product Phospho-Tyrosine CAS Number 150465-29-5 disodium salt, the new modified amino acid Sulfo- Molecular weight 250,23 Cysteine sodium salt can be used as replacement for Chemical Formula C3H6NNaO5S2 ·1.5H2O cysteine to generate highly concentrated, neutral pH Physicochemical feeds. Both modified amino acids eliminate the need Information for alkaline feeds, which are normally applied to ensure pH Value 5.0 - 8.0 (10g/L, H2O, RT) solubility and stability of the unmodified amino acids tyrosine and cysteine. Solubility Up to 1.3M (H2O, RT) Utilization of just one single, neutral pH feed is a revolutionary idea to simplify fed-batch processes. It optimizes the application by reducing the number of necessary feeds and corresponding materials, while also reducing pH spikes. It also allows the development of formulations which are stable at room temperature. The use of modified amino acids can furthermore have positive impacts on cell culture duration or productivity. The high feed concentration achievable using modified amino acids allows to lower the feed volume addition in biopharmaceutical manufacturing and thus may bring an increase in titer. In addition to showing strong positive characteristics for the use in biopharmaceutical processes, there is no impact of using modified amino acids on mAb glycosylation and charge variants. On top of that, sulfo-cysteine enables a significant reduction of fragmentation and trisulfide bonds linkages in IgG and therefore a better protein quality. The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada. Main Feed L-Tyr/L-Cys Feed Main Feed pH 5-6 high pH, neutral pH, high conc. Tyr/Cys high conc. Tyr/Cys Basal Medium Basal Medium Process simplification neutral pH, with incorporation of neutral pH, low conc. Tyr/Cys modified amino acids low conc. Tyr/Cys into one neutral pH main feed. • Unmodified cysteine and tyrosine require • Single addition of the modified amino acids, separate alkaline feed to be soluble (Tyr) at neutral pH, with the primary feed reduces and stable (Cys) at room temperature contamination risk and simplifies process • Multiple feed additions can increase • Stable feed solutions improve bioproduction contamination risk while also being less and require no additional pH adjustment preferred for larger scale bioproduction Benefits Ordering Information • Reduced complexity in fed-batch process Description Cat. No. • High concentrations of modified cysteine in main L-Cysteine S-sulfate Sodium Salt sesquihydrate 1.37116.0100 feeds at neutral pH Emprove® EXPERT – 100g › Simplify the process L-Cysteine S-sulfate Sodium Salt sesquihydrate 1.37116.1000 ® › Optimize productivity Emprove EXPERT – 1kg › Reduce total volume addition L-Cysteine S-sulfate Sodium Salt sesquihydrate 1.37116.5000 Emprove® EXPERT – 5kg • Prevention of caustic shocks in the bioreactor due to high pH feeds • More convenient preparation process with less contamination risks • Reduction of recombinant protein fragmentation and decrease in trisulfide bond content • Higher feed stability at room temperature • Supply Chain Transparency - Emprove® Expert documentation helps you meet the latest regulatory requirements • Vast knowledge base for application and technical support to integrate the product to your processes To place an order or receive technical assistance In the U.S. and Canada, call toll-free 1-800-645-5476 For other countries across Europe and the world, please visit: EMDMillipore.com/offices For Technical Service, please visit: EMDMillipore.com/techservice MilliporeSigma.com © 2018 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved. MilliporeSigma, the vibrant M, SAFC, and Emprove are Lit. No. MS_DS2120EN Ver. 2.0 trademarks of Merck KGaA, Darmstadt, Germany or its affiliates. All other trademarks are the property of their respective owners. Detailed 2018-11546 information on trademarks is available via publicly accessible resources. 05/2018.
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