DOCSLIB.ORG

Poster Sessions ALI and Inflammation 0035-0045

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Poster Sessions ALI and Inflammation 0035-0045 S14 19th ESICM Annual Congress – Barcelona, Spain – 24–27 September 2006 Poster Sessions 0037 CRITICAL ROLE OF NEUTROPHIL P21-ACTIVATED KINASE IN LPS-INDUCED ACUTE ALI and inflammation 0035-0045 LUNG INJURY 0035 Reutershan J1, Stockton R2, Zarbock A2, Sullivan G W2, Chang D2,ScottD2,SchwartzMA2,LeyK2 1 PENTRAXIN 3 (PTX3) AND C REACTIVE PROTEIN IN ALI/ARDS: PRELIMINARY University of Tuebingen, Dept. of Anaesthesiology and Intensive Care Medicine, Tuebingen, 2 RESULTS FROM A PROSPECTIVE STUDY Germany, University of Virginia, Robert M. Berne Cardiovascular Research Center, Charlottesville, United States Mauri T1, Coppadoro A1, Bellani G1, Bombino M1, Valentino S2, Patroniti N1, Mantovani A2, Pesenti A1 INTRODUCTION. Excessive recruitment of polymorphonuclear leukocytes (PMNs) into the lung 1Perioperative Medicine and Intensive Care, St Gerardo Hospital, Monza, 2Laboratory of Immunology is critical in the early phase of acute lung injury (ALI/ARDS). Although chemokines and adhesion and Cell Biology, Humanitas Clinical Institute, Rozzano, Italy molecules have been demonstrated to initiate leukocyte-endothelial interaction, pathways which regu- late PMN migration through the alveolo-capillary membrane remain to be identified. Here, we studied INTRODUCTION. PTX3 has recently been described as an acute phase mediator of innate immunity. the role of the small GTPases effector p21-activated kinase (PAK) for PMN migration in LPS-induced Together with C Reactive Protein (CRP), it belongs to the pentraxin superfamily. PTX3 is produced ALI. by a variety of cells, located almost everywhere (e.g. dendritic cells), while CRP is produced only by the liver. PTX3 plays a key role in the activation and the amplification of inflammation. ALI/ARDS is METHODS. LPS-induced PMN migration into the different compartments of the lung was investi- characterized by an important inflammatory reaction, often both local and systemic. gated in wild type male C57Bl/6 mice. PAK activity was inhibited by injecting a specific blocking peptide. A fluorescent blocking peptide was injected to investigate its cellular targets in vivo. PMN METHODS. We enrolled 9 patients affected by ALI/ARDS. We measured PTX3 and CRP levels migration through a layer of pulmonary endothelial cells was investigated to determine the role of neu- on the first 2 days from ICU admission, then every three days for the first month and then once a trophil PAK. To test whether this translates to humans, F-actin polymerization, oxidative burst, and week, until ICU discharge. We also measured PTX3 levels in the bronco alveolar lavage (BAL) fluid. adhesion were investigated in human PMNs. 102 plasma samples and 14 BAL fluids were collected and tested. We registered data on etiology, pulmonary mechanics, gas exchange, systemic inflammation, organs function, blood cells counts and RESULTS. PMN migration into the lung interstitium and alveolar airspace, but not accumulation in outcome at hospital discharge. the pulmonary vasculature was reduced when PAK activity was blocked. Injection of a fluorescently labeled peptide identified leukocytes as a major cellular target for its blocking activity. The majority of RESULTS. PTX3 plasma levels were high and within a very wide range (2.02-3872.64 ng/ml; 111.47 fluorescent PMNs were found in the blood, while no positive PMNs were found in the BAL, indicating ± 467.21 ng/ml), while CRP levels were relatively low and less variable (0.16-49 mg/dl; 15.94 ± 11.14 that PAK-activation was required for PMNs to emigrate from the circulation. In addition, migration mg/dl). The levels of the two mediators showed no correlation. PTX3 was present in BAL fluids in vari- towards a chemotactic gradient was reduced when PAK activity was blocked in PMNs, highlighting a able concentrations (0-19.4 ng/ml; 3.28 ± 5.63 ng/ml). We found a significant correlation (p<0.05; r critical role for PAK in PMNs. In human PMNs, blocking PAK activity disrupted F-actin polymeriza- 0.673) between the levels of PTX3 in BAL fluid and plasma. PTX3 levels on the first day were sig- tion, static adhesion, and oxidative burst of adherent PMNs. nificantly different between survivors and not-survivors at hospital discharge (p<0.05; 1.310±0.457 log(ng/ml) vs 2.401±0.825 log(ng/ml)). Moreover PTX3 values were significantly higher in patients CONCLUSION. PAK is a critical mediator of LPS-induced PMN migration into the lung and may be with septic shock than in non shock patients (p<0.05; 1.532±0.794 vs 1.223±0.478 log(ng/ml)). PTX3 an attractive target for the treatment of acute lung injury. values were significantly (p<0.05) related to SvO (r -0.316), arterial blood pH (r -0.371) and SOFA 2 REFERENCE(S). 1. Reutershan J, Sequential recruitment of neutrophils into lung and bronchoalve- values (r 0.591). olar lavage fluid in LPS-induced acute lung injury. AJP Lung 2005 289:L807-L815. 2. Stockton RA, CONCLUSION. PTX3 seems to be a key factor for the development, the amplification and the out- p21-activated kinase regulates endothelial permeability through modulation of contractility. JBC 2004 come of this syndrome; the levels of the two mediators appear not to be related, suggesting a possible 279:46621-46630. individual role for each one. Grant acknowledgement. German Research Foundation (grant RE 1683/2-1 to JR) and NIH grant Grant acknowledgement. MIUR, Roma, Italy HL73361 to KL. 0036 0038 NATRIURETIC PEPTIDES FOR THE ASSESSMENT OF SMOKE INHALATION INJURY IMPACT OF TRANSFORMING GROWTH FACTOR BETAˆ 1 AND PROCOLLAGEN III ON THE MORTALITY OF ACUTE RESPIRATORY DISTRESS SYNDROME Reper P A1,VanLoeyKE1 1Critical Care Department, Queen Astrid Hospital, Brussels, Belgium Forel J1,DemoryD1, Guervilly C1,RochA1,MarinV2,ArnalJ3, Donati Y3, Embriaco N1, Gainnier M1, Papazian L1 INTRODUCTION. Smoke intoxication remains a major cause of mortality after smoke inhalation 1Medical Intensive Care Unit, 2Immunology Laboratory, Hˆopitaux Sud Assistance Publique - Hˆopitaux and remains difficult to evaluate by biological markers. de Marseille, Marseille, 3Intensive Care Unit, Hˆopital Font-Pr´e, Toulon, France Increased plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been identified as predictors of cardiac dysfunction and prognosis in congestive heart failure and is- INTRODUCTION. To determine whether blood and bronchoalveolar lavage fluid levels of the TGFβ- chemic heart disease. 1 and the Procollagen III (PIIINP) are associated with the mortality of patients with ARDS. In severe sepsis patients, some data are now available about the possible prognostic value of natriuretic peptides. METHODS. We included 56 patients with ARDS, after patient’s next of kin consent, in a prospec- The aim of the present study was to determine the role of the N-terminal prohormone forms of ANP tive study. Patients were ventilated with a protective mechanical ventilation according to NIH. Bron- (NT-proANP) and BNP (NT-proBNP) after smoke inhalation injury. choalveolar lavages (BAL) and blood samples were performed on the first 48 hrs of ARDS for dosing TGFβ-1 and PIIINP. Survival was registered at day 28. BAL and blood levels of TGFβ-1 and PIIINP METHODS. Retrospective, clinical study in a specialised burn intensive care unit. Population: 9 pa- were compared by Mann-Whitney test. We determined cut-off values of these mediators using ROC tients with severe inhalation injury confirmed by fiberoptic examination and clinical findings (close curves. Multivariate logistic regression was performed to determine the effect of TGFβ-1 and PIIINP space fire, soot on the face and in the mouth; HbCO >10%) and 10 control subjects with no smoke on the risk of death while controlling the effect of age, sexe, SOFA, Lung injury score, PaO2/FiO2, exposure. All the patients had burn wounds < 5 ± 2% TBSA. polymorphonuclear count in BAL. Collection of clinical and demographic data in relation to ANP, BNP, and IL-6 in plasma over a period of 4 days. RESULTS. Table 1 shows the levels of PIIINP in survivors and non survivors. BAL fluid and blood levels of TGFβ-1 were not statistically differents in survivors and nonsurvivors. Table 2 summarizes RESULTS. There was no significant difference between the two groups for age, burn surface area, and the results of the multivariate analysis. medical history. We found a significant increase in ANP (113.7+/-9.9 vs. 13.8+/-1.3 pg/ml) and BNP (81.4+/-3.6 vs. TABLE 1. 6.5+/-0.8 pg/ml) after inhalation injury. Levels of PIIINP (µg/L) in BAL fluid and blood in survivors and non survivors Plasma ANP peaked together with IL-6 and peaks of ANP and IL-6 were significantly correlated Survivors (n=36) Nonsurvivors (n=20) p value (p<0.01). BAL levels of PIIINP 1.7 [0.7-4.1] 5.9 [1.7-24.1] 0.024 CONCLUSION. ANP and BNP increase significantly in patients with severe inhalation injury. Blood levels of PIIINP 7.7 [5.0-10.7] 14.9 [9.3-18.6] 0.001 BNP reflects left ventricular dysfunction and could be related to the potential cardiac depression fol- lowing smoke intoxication and particularly cyanide and carbon monoxyde exposition associated with TABLE 2. hypoxaemic conditions. Results of multivariate analysis for the risk of death determined on inclusion ANP is related to IL-6 production rather than to cardiovascular dysfunction. Odds Ratio (95% CI) p value Further studies are necessary to confirm these preliminary results. Blood levels of PIIINP>=8.95µg/L 4.82 (1.16-20.01) 0.03 BAL levels of PIIINP >=4.0µg/L 4.27 (1.07-16.99) 0.04 CONCLUSION. Early increased levels of Procollagen III Peptide in blood and in BAL fluid, but not levels of Transforming Growth Factor β-1, are associated with an increased risk of death in patient with acute respiratory distress syndrome.
Load more

Recommended publications
  • Civil Society, Government and the Opposition Movements in Poland: the Post-Communist Role Reversal
    e W E E R / Warsaw East European Conferenc e W E E R / Warsaw East European Conferenc INTERNAT I ONAL BOARD : Egidijus Aleksandravičius, Vytautas Magnus University Stefano Bianchini, University of Bologna Miroslav Hroch, Charles University Yaroslav Hrytsak, Ukrainian Catholic University Andreas Kappeler, University of Vienna Zbigniew Kruszewski, University of Texas, El Paso Jan Kubik, Rutgers University Panayot Karagyozov, Sofia University Alexey Miller, Russian Academy of Sciences Richard Pipes, Harvard University Mykola Riabchuk, Kyiv-Mohyla Academy Alexander Rondeli, Georgian Foundation for Strategic and International Studies John Micgiel, Columbia University Barbara Törnquist-Plewa, Lund University Theodore Weeks, Southern Illinois University ED I TOR I AL COMM I TTEE : Jan Malicki, University of Warsaw (Director of the WEEC – Warsaw East European Conference, chair of the Committee) Leszek Zasztowt (chair of the WEEC Board), University of Warsaw Andrzej Żbikowski (secretary of the WEEC Board, University of Warsaw ED I TOR -I N -CH I EF Jerzy Kozakiewicz, University of Warsaw ASS I STANT ED I TOR Konrad Zasztowt, University of Warsaw ISBN: 978-83-61325-32-1 ISSN: 2299-2421 Copyright © by Studium Europy Wschodniej UW 2013 COVER AND TYPOGRAPH ic DES I GN J.M & J.J.M. LAYOUT Jan Malik, “MALGRAF” PR I NT I NG Zakład Graficzny UW, nr zam. 780/2013 Foreword ........................................................................................................... 9 I. POLAND Galia Chimiak, The Evolution of the Vision of Civil Society in Poland ..................... 13 Beata Halicka, The Shifting of Borders in 1945 in Memory of Poles, Germans and 29 Ukrainians ....................................................................................................... Richard J. Hunter, Leo V. Ryan, Economic Transformation and Privatization .......... 37 Magda Stroińska, Civil Society, Government and the Opposition Movements in Po- land: The Post-Communist Role Reversal ..........................................................
    [Show full text]
  • National and International Security in Contemporary Changing Reality
    National and International Security in Contemporary Changing Reality SECURITY SCIENCIES FACULTY EDITORIAL SERIES SCIENTIFIC BOARD ANDRZEJ FRYCZ MODRZEWSKI KRAKOW UNIVERSITY National and International Security in Contemporary Changing Reality Part 1 ed by Mieczysław Bieniek, Sławomir Mazur Andrzej Frycz Modrzewski Krakow University Security Sciencies Faculty 2012 / nr 1 Editorial Council of the Andrzej Frycz Modrzewski Krakow University: Klemens Budzowski, Maria Kapiszewska, Zbigniew Maciąg, Jacek M. Majchrowski Andrzej Frycz Modrzewski Krakow University www.ka.edu.pl Scien fi c Board Faculty of Security Studies Andrzej Frycz Modrzewski Krakow University Mieczysław Bieniek (Poland), Henryk Ćwięk (Poland), Edward Gruszka (Poland), Vladimir Janeček (Slovakia), Janusz Kręcikij (Poland), Sławomir M. Mazur – chief (Poland), François Fd Miche (Switzerland), Cindy Miller (USA), Monika Ostrowska (Poland), Eric Pouliquen (France), Michal Pružinský (Slovakia), Jan Widacki (Poland), Karl-Heinz Viereck (Germany) Scien fi c Editor: Mieczysław Bieniek, Sławomir M. Mazur Reviewer: prof. Jarosław Wołejszo, PhD Proof-reading: Gregory White Cover design: Oleg Aleksejczuk On the cover side: reverse of the medal “For Merit to the Andrzej Frycz Modrzewski Krakow University Security Sciencies Faculty” Design and performance: prof. Czeslaw Dźwigaj ISBN 978-83-7571-273-5 Copyright© by Andrzej Frycz Modrzewski Krakow University Kraków 2012 All Rights Reserved. No part of this publica on or its en rety may be reproduced, transmi ed or stored in any manner that allows
    [Show full text]
  • Warsaw East European Review Review European East Warsaw More Information on Recruitment: Volume I1/2012
    Warsaw East European Conference vol. ii/2012 • In the academic year 2012/2013 THE CENTRE FOR EAST EUROPEAN STUDIES will be inviting applications for the following scholarship programs: ◆ The Kalinowski Scholarship Program ◆ Scholarships of the Polish Government for Young Academicians ◆ 25 scholarships to enter the 2-year Master’s Program in Specialist Eastern Studies ◆ The Lane Kirkland Scholarship Program Warsaw East ◆ The Krzysztof Skubiszewski Scholarship European Review Warsaw East European Review Review European East Warsaw More information on recruitment: www.studium.uw.edu.pl volume i1/2012 R Warsaw East European Conference Okl_Warsaw East European Review 2012.indd 1 2012-07-09 08:27:20 e W E E R / Warsaw East European Conferenc e W E E R / Warsaw East European Conferenc INTERNAT I ONAL BOARD : Egidijus Aleksandravičius, Vytautas Magnus University Stefano Bianchini, University of Bologna Miroslav Hroch, Charles University Yaroslav Hrytsak, Ukrainian Catholic University Andreas Kappeler, University of Vienna Zbigniew Kruszewski, University of Texas, El Paso Jan Kubik, Rutgers University Alexey Miller, Russian Academy of Sciences Richard Pipes, Harvard University Mykola Riabchuk, Kyiv-Mohyla Academy Alexander Rondeli, Georgian Foundation for Strategic and International Studies John Micgiel, Columbia University Barbara Törnquist-Plewa, Lund University Theodore Weeks, Southern Illinois University ED I TOR I AL COMM I TTEE : Jan Malicki, University of Warsaw (Director of the WEEC – Warsaw East European Conference, chair of the Committee) Leszek Zasztowt (chair of the WEEC Board), University of Warsaw Andrzej Żbikowski (secretary of the WEEC Board, University of Warsaw ED I TOR -I N -CH I EF Jerzy Kozakiewicz, University of Warsaw ASS I STANT ED I TOR Konrad Zasztowt, University of Warsaw ISBN: 978-83-61325-239 ISSN: 2299-2421 Copyright © by Studium Europy Wschodniej UW 2012 COVER AND TYPOGRAPH ic DES I GN J.M & J.J.M.
    [Show full text]
  • Final List of Participants
    Plenipotentiary Conference (PP-06) Antalya, 6-24 November 2006 Final list of participants 1) Member States 2) Observers - Resolution 99 (PP-98) 3) Observers - United Nations and its Specialized Agencies 4) Observers - Regional Telecommunication Organizations 5) Observers - Recognized Operating Agencies (CV229) invited pursuant to Number 269E of the Convention 6) Observers - Scientific or Industrial Organizations (CV229) invited pursuant to Number 269E of the Convention 7) Observers - Regional and other International Organizations (CV231) invited pursuant to Number 269E of the Convention vendredi, 24. novembre 2006 Page 1 of 48 1) MEMBER STATES Afghanistan C H.E. Mr Mr. Amirzai SANGIN, Minister of Communications, Ministry of Communications, [email protected], Box: 621 CA H.E. Mr Mr. Baryalai HASSAM, Deputy Minister " Technical ", Ministry of Communications, [email protected], Box: 282 D Mr Mr. Ajmal AYAN, Director of Research & Development, Ministry of Communications, [email protected], Box: 283 D Mr Oliver ODZIGGEL, Advisor to Atra, Ministry of Communications, [email protected], Box: 3397 Albania C Mr Etion KAPEDANI, Director of Information Technology, Delegation of Albania, [email protected], Box: 3345 D Mr Hydajet KOPANI, Executive Director, Delegation of Albania, [email protected], Box: 3346 D Mr Arian SINOIMERI, Tre Board Memeber, Telecommunication Regulatory Entity, [email protected] Algeria C H.E. Mr Boudjemaa HAICHOUR, Ministre de la Poste et des Technologies de l'information et de la Communication, Ministère
    [Show full text]
  • Hubert Bals Fund
    International Film Festival Rotterdam Hubert Bals Fund Annual Report 2015-2016 Table of Contents Brief overview 2015-2016 5 Appendix 18 Background Hubert Bals Fund 7 Organisation and selection committee 18 Activities and Results 11 Statement of Income and Expenditure 18 Selection Process 11 HBF selected projects 21 Funding film projects 11 HBF Harvest at IFFR 2016 25 Festival circulation and distribution 13 Circulation overview of HBF-supported films 26 HBF network 17 Credits 35 2 3 Ixcanul, Jayro Bustamante, Guatemala, 2015 Filmmakers’ Stories: Felipe Guerrero Brief overview of Colombian filmmaker Felipe Guerrero 2015-2016 has just turned forty. He has been The Hubert Bals Fund (HBF) started out as a pioneer. Since 1988, the editing documentaries for many years. HBF has helped talent from Africa, Asia, Latin America, the Middle East At International Film Festival Rotterdam, and parts of Eastern Europe to make their film dreams reality. The success he presented his third film: Oscuro of HBF-backed films in Rotterdam and abroad is proof of the synergetic animal. A film that follows the journeys effectiveness of the three-stage rocket launcher made up of International of three women forced by the violence Film Festival Rotterdam, CineMart and HBF. of war to flee their homes and survive in the rainforest. Like his previous two films, Oscuro Since its foundation in 1988, the Fund has contributed to Financial situation 1,103 projects from Asia, Africa, Latin America, the Middle The HBF is supported by the Creative Europe MEDIA animal (literally: dark animal) is about East and parts of Eastern Europe.
    [Show full text]
  • Sierra Leone (1997) and the Gambia (2017)
    Maria Opoku-Aikins A COMPARATIVE STUDY OF ECOWAS’ INTERVENTIONS IN LIBERIA (1989), SIERRA LEONE (1997) AND THE GAMBIA (2017) Faculty of Social Sciences Master’s Thesis January 2019 ABSTRACT Maria Opoku-Aikins: A Comparative Study of ECOWAS’ Interventions in Liberia (1989), Sierra Leone (1997) and The Gambia (2017) Master’s Thesis Tampere University Master’s Programme in Peace, Mediation and Conflict Research January 2019 Since the post-cold war era, West Africa has been experiencing violent intra- state conflicts which have escalated to extreme levels and lasted over decades at a time, which led to serious security threats in the region. ECOWAS, created initially with an objective of promoting economic integration and development in West Africa, amended its mandate to include conflict management. Since its establishment, ECOWAS has engaged in several interventions in its member states, of which Liberia, Sierra Leone and The Gambia are part and were researched in this study. The purpose of this study was to evaluate ECOWAS and its regional conflict prevention strategies, as well as make inquiries into ECOWAS’ policies for reducing security threats in the region. The study employed a qualitative approach to identify the similarities and differences between these three interventions; to determine the challenges faced in each intervention and to determine if ECOWAS took measures to address these challenges prior to subsequent interventions. The findings of the study showed that the conflicts in Liberia and Sierra Leone, which occurred in the early 1990’s, had similar causes, such as subdivisions among ethnicities, extreme political marginalization, poor democratic management and economic hardship. In both cases, the UN had to intervene before the conflicts could be resolved.
    [Show full text]
  • Other Minds Records
    http://oac.cdlib.org/findaid/ark:/13030/c8wq0984 Online items available Guide to the Other Minds Records Alix Norton, Jay Arms, Madison Heying, Jon Myers, and Kate Dundon University of California, Santa Cruz 2018 1156 High Street Santa Cruz 95064 [email protected] URL: http://guides.library.ucsc.edu/speccoll Guide to the Other Minds Records MS.414 1 Contributing Institution: University of California, Santa Cruz Title: Other Minds records Creator: Other Minds (Organization) Identifier/Call Number: MS.414 Physical Description: 399.75 Linear Feet (404 boxes, 15 framed and oversized items) Physical Description: 0.17 GB (3,565 digital files, approximately 550 unprocessed CDs, and approximately 10 unprocessed DVDs) Date (inclusive): 1918-2018 Date (bulk): 1981-2015 Language of Material: English https://n2t.net/ark:/38305/f1zk5ftt Access Collection is open for research. Audiovisual media is unavailable until reformatted. Digital files are available in the UCSC Special Collections and Archives reading room. Some files may require reformatting before they can be accessed. Technical limitations may hinder the Library's ability to provide access to some digital files. Access to digital files on original carriers is prohibited; users must request to view access copies. Contact Special Collections and Archives in advance to request access to audiovisual media and digital files. Publication Rights Property rights for this collection reside with the University of California. Literary rights, including copyright, are retained by the creators and their heirs. The publication or use of any work protected by copyright beyond that allowed by fair use for research or educational purposes requires written permission from the copyright owner.
    [Show full text]
  • Essays on Attractiveness of Multinational Corporations Nikolay Anguelov Clemson University, [email protected]
    Clemson University TigerPrints All Dissertations Dissertations 8-2012 Essays on Attractiveness of Multinational Corporations Nikolay Anguelov Clemson University, [email protected] Follow this and additional works at: https://tigerprints.clemson.edu/all_dissertations Part of the Public Policy Commons Recommended Citation Anguelov, Nikolay, "Essays on Attractiveness of Multinational Corporations" (2012). All Dissertations. 989. https://tigerprints.clemson.edu/all_dissertations/989 This Dissertation is brought to you for free and open access by the Dissertations at TigerPrints. It has been accepted for inclusion in All Dissertations by an authorized administrator of TigerPrints. For more information, please contact [email protected]. ESSAYS ON ATTRACTIVENESS OF MULTINATIONAL CORPORATIONS _______________________________________________________ A Dissertation Presented to The Graduate School of Clemson University _______________________________________________________ In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Policy Studies, _______________________________________________________ by Nikolay G. Anguelov August 2012 ______________________________________________________ Accepted by: Dr. Aleda V. Roth, Committee Co-Chair Dr. William A. Ward, Committee Co-Chair Dr. Holley Ulbrich Dr. Joseph Stewart Jr. Dr. Jeffrey Fine ABSTRACT This dissertation analyzes selected policies designed to attract foreign direct investment (FDI) as a means of economic growth. The focus is on multinational corporations (MNCs)
    [Show full text]
  • Strasbourg, 21 May 2010
    Strasbourg, 3 September 2010 CDMC(2010)008 Français Pdf STEERING COMMITTEE ON THE MEDIA AND NEW COMMUNICATION SERVICES (CDMC) ______ 12th meeting from 8 to 11 June 2010 Council of Europe, Agora building, Strasbourg (Room G02) Meeting report ______ Executive summary During the meeting, the CDMC: - finalised a draft declaration on the digital agenda for Europe and submitted it to the Committee of Ministers for adoption; - finalised a draft declaration on the management on the Internet protocol address resources in the public interest and submitted it to the Committee of Ministers for adoption; - finalised a draft declaration on network neutrality and submitted it to the Committee of Ministers for adoption; _________________________________ This document will not be distributed at the meeting. Please bring this copy. Ce document ne sera pas distribué en réunion. Prière de vous munir de cet exemplaire. CDMC(2010)008 2 - adopted comments on Parliamentary Assembly Recommendation 1906(2010) on Rethinking creative rights for the Internet age; - agreed on a lists of experts for its ad hoc advisory groups on the protection of neighbouring rights, pending the obtention of a negotiating mandate by the European Commission that will condition the continuation of the work; - took note of progress made by the Committee of Experts on New Media, the Ad Hoc Advisory Group on Cross-Border Internet and the Ad Hoc Advisory Group on Public Service Media Governance; - following a presentation on the European Commission’s Public value test (Amsterdam test), held an exchange of views with the representative of the EC on the subject; - decided to set up a small informal working group to explore possible guidance to review their national anti-terrorism legislation and practice and their impact on freedom of expression; - agreed on proposals made in respect of mainstreaming gender issues in its work.
    [Show full text]
  • Pdf Annual Report 2011
    OSA Yearbook 2011 Ochranný svaz autorský pro práva k dílům hudebním, o.s. OSA (Society for the Protection of the Rights of Music Authors and Publishers) has administered the economic copyrights of composers, lyricists, their heirs, and publishers since 1919; is a civic association based on a not-for-profit principle; OSA’s income from collective management is not the company’s profit but the income of individual copyright holders whose works are used in the given year; protects the rights of authors against the users of musical works and helps authors obtain fair royalties for the use of their musical works; pays royalties regularly within scheduled deadlines four times a year; under reciprocal agreements with foreign societies of authors, ensures the collection of royalties for the use of the works of authors and publishers represented by OSA abroad; all the royalty fees collected from users of musical works are distributed among local and foreign rights holders, after deduction of justified expenses; helps users acquire the right to use music legally; one place = global repertoire – users need not ask composers and lyricists individually for permission to use their musical works; offers tens of millions of pieces from all around the world based on contracts of representation; offers musical works of nearly 7 thousand Czech authors and publishers over 1 million foreign authors; supports numerous musical projects via the OSA Partnership and the OSA Music Foundation. 3 Table of content 4 Foreword 5 About Us 8 Organisational structure 8
    [Show full text]
  • Vol. 10 Numer 4 2016
    ISSN 1897-5577 Ius Novum Vol. 10 Numer 4 2016 październik–grudzień KWARTALNIK WYDZIAŁU PRAWA I ADMINISTRACJI UCZELNI ŁAZARSKIEGO WARSZAWA 2016 RADA NAUKOWA / ADVISORY BOARD prof. dr hab. Maria Kruk-Jarosz, Uczelnia Łazarskiego (przewodnicząca) prof. dr hab. Sylvie Bernigasud, l’Université Lumière Lyon 2 (Francja) prof. dr hab. Vincent Correia, Université Paris-Sud, Université de Poitiers (Francja) prof. dr hab. Bertil Cottier, Università della Svizzera Italiana w Lugano (Szwajcaria) prof. dr hab. Regina Garcimartín Montero, Universidad de Zaragoza (Hiszpania) prof. dr Juana María Gil Ruiz, Universidad de Granada (Hiszpania) prof. dr hab. Stephan Hobe, Cologne University (Niemcy) prof. dr hab. dr h.c. Brunon Hołyst, Uczelnia Łazarskiego prof. dr hab. Michele Indellicato, Università degli Studi di Bari Aldo Moro (Włochy) prof. dr hab. Hugues Kenfack, Université Toulouse 1 w Tuluzie (Francja) prof. dr hab. ks. Franciszek Longchamps de Bérier, Uniwersytet Jagielloński prof. dr hab. Pablo Mendes de Leon, Leiden University (Holandia) prof. dr hab. Adam Olejniczak, Uniwersytet Adama Mickiewicza w Poznaniu prof. dr Ferdinando Parente, Università degli Studi di Bari Aldo Moro (Włochy) prof. dr hab. Grzegorz Rydlewski, Uniwersytet Warszawski prof. dr hab. Vinai Kumar Singh, New Delhi, Indian Society of International Law (Indie) prof. dr hab. Gintaras Švedas, Vilniaus Universitetas (Litwa) prof. dr hab. Anita Ušacka, sędzia Międzynarodowego Trybunału Karnego w Hadze (Holandia) dr Ewa Weigend, Instytut Prawa Karnego Max-Plancka we Freiburgu (Niemcy)
    [Show full text]
  • Final Report of the Panel of Experts on South Sudan
    United Nations S/2017/326 Security Council Distr.: General 13 April 2017 Original: English Letter dated 13 April 2017 from the Panel of Experts on South Sudan established pursuant to Security Council resolution 2206 (2015) addressed to the President of the Security Council The members of the Panel of Experts established pursuant to Security Council resolution 2206 (2015), whose mandate was extended pursuant to resolution 2290 (2016), have the honour to transmit herewith, in accordance with paragraph 12 (d) of resolution 2290 (2016), the final report on their work. The report was provided to the Security Council Committee established pursuant to resolution 2206 (2015) concerning South Sudan on 16 March 2017 and was considered by the Committee on 29 March 2017. The Panel would appreciate if the present letter and the report were brought to the attention of the members of the Security Council and issued as a document of the Council. (Signed) Klem Ryan Acting Coordinator Panel of Experts on South Sudan (Signed) Andrews Atta-Asamoah Expert (Signed) Payton Knopf Expert (Signed) Andrei Kolmakov Expert (Signed) Anna Oosterlinck Expert 17-04364 (E) 190417 *1704364* S/2017/326 Final report of the Panel of Experts on South Sudan Summary The de facto collapse of the transitional government of national unity envisaged in the Agreement on the Resolution of the Conflict in the Republic of South Sudan of August 2015, as described in the Panel’s reports of September and November 2016 (S/2016/793 and S/2016/963), has left South Sudan with a political arrangement between the President, Salva Kiir, and the First Vice-President, Taban Deng Gai, that does not meaningfully include significant segments of the opposition, other political factions and many influential non-Dinka community leaders.
    [Show full text]