JUST U.S. Large Cap Diversified Index (JULCD) Q1 2021
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Prostate Cancer in Focus
PROSTATE CANCER IN FOCUS Current Developments in the Management of Prostate Cancer Section Editor: Andrew J. Armstrong, MD Prostate Cancer Prostate PSMA-Targeted Therapy in Prostate Cancer Scott T. Tagawa, MD, MS Professor of Medicine and Urology Weill Cornell Medicine New York, New York H&O What is prostate-specific membrane agent such as a monoclonal antibody might be able to antigen (PSMA), and what makes it a good target target a tumor without binding to other PSMA-positive for the treatment of prostate cancer? sites owing to its large size and physical inability to reach luminal sites of expression that are separated from the ST PSMA is a cell surface antigen that is expressed to vasculature by tight junctions. a limited degree on certain normal cells in the body but generally is highly overexpressed in the setting of prostate H&O How is PSMA positivity established? cancer. Normal cells that express PSMA are located in the prostate, salivary, and lacrimal glands; the proximal part ST Imaging and biopsy are the main ways to establish of the small intestine; the proximal renal tubules; and PSMA positivity. Multiple imaging modalities are avail- some ganglia. In the setting of prostate cancer, PSMA able worldwide. The agent indium In 111 capromab expression generally increases along with the cancer grade, pendetide (ProstaScint) has been approved for years in and it also increases following hormonal therapy. In addi- the United States, and the US Food and Drug Adminis- tion, PSMA expression tends to be higher in metastatic tration (FDA) approved the use of gallium Ga 68 PSMA- sites than in primary tumors. -
Invest in Your Retirement—And Yourself—Today, with Help from Comcast Corporation Retirement-Investment Plan and Fidelity
Comcast Corporation Retirement-Investment Plan Invest in your retirement—and yourself—today, with help from Comcast Corporation Retirement-Investment Plan and Fidelity. YOUR GUIDE TO GETTING STARTED Invest some of what you earn today for what you plan to accomplish tomorrow. Dear Comcaster: It is our pleasure to offer you the opportunity to participate in the Comcast Corporation Retirement- Investment Plan (the ’Comcast Plan’). Your retirement savings plan offers a convenient, tax-deferred way to save for retirement. As an eligible employee of Comcast Corporation, you will be automatically enrolled in the Plan at a contribution rate of 3% of your pretax eligible earnings. Benefit from: Matching contributions. Comcast helps your contributions grow by matching your 401(k) contributions. Convenience. Your contributions are automatically deducted regularly from your paycheck. Tax-deferred savings opportunities. You pay no taxes on any earnings until you withdraw them from your account, enabling you to keep more of your money working for you now. Tax savings now. Your pretax contributions are deducted from your pay before income taxes are taken out. This means that you can actually lower the amount of current income taxes withheld each period. It could mean more money in your take-home pay versus saving money in a taxable account. Portability. You can roll over eligible savings from a previous employer into this Plan. You can also take your vested account balance with you if you leave the company. Automatic annual increases. Save a little more each year, the easy way — the Annual Increase Program automatically increases your contribution rate by 1% each year up to 10% of your pretax eligible earnings. -
STRS Ohio Smarttalk Newsletter
Quarterly investment newsletter for STRS Ohio members participating in the Defined Contribution and Combined Plans SUMMER 2021 STRS Ohio’s Fiscal 2022 Investment Plan calls for returns near expected policy return of 6.84% in the year ahead STRS Ohio Investment staff presented its Investment The Retirement Board’s investment consultants, Callan LLC Plan for the 2022 fiscal year at the June Retirement Board and Cliffwater LLC, reviewed and expressed support for meeting. The plan details staff’s investment strategy for the Investment Plan. The plan is available on the STRS Ohio each asset class in the system’s total fund. Fiscal year 2022 website at www.strsoh.org. STRS Ohio’s plan and forecast began on July 1 and runs through June 30, 2022. The fiscal is designed for a large institutional investor and may 2022 Investment Plan projects a combined overall return not be appropriate to an individual investor’s portfolio among all asset classes to be near STRS Ohio’s expected allocation, time horizon or risk tolerance. Like all economic policy return of 6.84% (assuming the total fund’s current forecasts, it should not be relied upon as an indicator of allocation). The plan forecast calls for a growing U.S. future results. For more personalized assistance, you can economy and for inflation to remain within a tolerable reach a Nationwide Retirement Solutions (NRS) Retirement range during the fiscal year. Specialist toll-free at 866-332-3342. Review your asset allocation Investment Style Asset Classes (allocation) ■ Cash 30% following strong equity market returns ■ Bonds 40% Domestic and international equity returns have been exceptionally CONSERVATIVE ■ Large-cap stocks 16% ■ Mid-cap stocks 4% strong for over a year now. -
Refreshing the Biologic Pipeline 2020
news feature Credit: Science Lab / Alamy Stock Photo Refreshing the biologic pipeline 2020 In the absence of face-to-face meetings, FDA and industry implemented regulatory workarounds to maintain drug and biologics approvals. These could be here to stay. John Hodgson OVID-19 might have been expected since 1996) — a small miracle in itself “COVID-19 confronted us with the need to severely impair drug approvals (Fig. 1 and Table 1). to better triage sponsors’ questions,” says Cin 2020. In the event, however, To the usual crop of rare disease and Peter Marks, the director of the Center for industry and regulators delivered a small genetic-niche cancer treatments, 2020 Biologics Evaluation and Research (CBER) miracle. They found workarounds and also added a chimeric antigen receptor at the FDA. “That was perhaps the single surrogate methods of engagement. Starting (CAR)-T cell therapy with a cleaner biggest takeaway from the pandemic related in January 2020, when the outbreak veered manufacturing process and the first to product applications.” Marks says that it westward, the number of face-to face approved blockbuster indication for a became very apparent with some COVID- meetings declined rapidly; by March, small-interfering RNA (siRNA) — the 19-related files that resolving a single they were replaced by Webex and Teams. European Medicines Agency’s (EMA) issue can help a sponsor enormously and (Secure Zoom meeting are to be added registration of the RNA interference accelerate the development cycle. Before this year.) And remarkably, by 31 December, (RNAi) therapy Leqvio (inclisiran) for COVID-19, it was conceivable that a small the US Food and Drug Administration cardiovascular disease. -
VIRTUS ZEVENBERGEN INNOVATIVE GROWTH STOCK FUND SCHEDULE of INVESTMENTS (Unaudited) MARCH 31, 2021
VIRTUS ZEVENBERGEN INNOVATIVE GROWTH STOCK FUND SCHEDULE OF INVESTMENTS (Unaudited) MARCH 31, 2021 ($ reported in thousands) Shares Value Shares Value Footnote Legend: (1) Non-income producing. COMMON STOCKS—99.0% Industrials—3.9% Communication Services—9.3% Desktop Metal, Inc. (1) Country Weightings† Coursera, Inc.(1) 7,100 $ 320 Class A 359,800 $ 5,361 (1) Uber Technologies, United States 87% Netflix, Inc. 84,500 44,080 (1) Snap, Inc. Class A(1) 586,650 30,676 Inc. 897,900 48,944 Canada 7 Zillow Group, Inc. 54,305 Brazil 5 Class C(1) 434,335 56,307 Israel 1 Information Technology—43.9% Total 100% 131,383 (1) Coupa Software, Inc. 78,450 19,964 † (1) % of total investments as of March 31, 2021. Consumer Discretionary—25.3% fuboTV, Inc. 315,350 6,976 (1) NVIDIA Corp. 107,000 57,131 Airbnb, Inc. Class A 91,100 17,121 (1) Amazon.com, Inc.(1) 15,200 47,030 Okta, Inc. 235,575 51,928 (1) Paylocity Holding Chegg, Inc. 322,325 27,610 (1) (1) Corp. 110,750 19,916 Chewy, Inc. Class A 340,400 28,835 (1) Fiverr International PayPal Holdings, Inc. 198,850 48,289 Ltd.(1) 27,650 6,005 QUALCOMM, Inc. 204,050 27,055 RingCentral, Inc. Lululemon Athletica, (1) (1) Class A 129,800 38,665 Inc. 41,690 12,787 (1) (1) ServiceNow, Inc. 78,325 39,171 MercadoLibre, Inc. 48,225 70,994 (1) Peloton Interactive, Inc. Shopify, Inc. Class A 78,200 86,528 (1) Snowflake, Inc. Class A 336,850 37,876 (1) Tesla, Inc.(1) 162,740 108,699 Class A 110,700 25,381 Sprout Social, Inc. -
Doctor of Pharmacy Fellowship Program
2021-2022 Doctor of Pharmacy Fellowship Program Accelerate your career with one of our 1-year fellowship programs Transformative Therapies Targeting Cancer Seagen Inc. is a global biotechnology company dedicated to discovering, developing, and commercializing transformative YEARS: In oncology for 23+ years cancer medicines to make a meaningful difference in people’s lives. SIZE: Largest biotechnology company ADCETRIS® (brentuximab vedotin) and PADCEV® (enfortumab vedotin-ejfv) use based in the Pacific Northwest the company’s industry-leading antibody-drug conjugate (ADC) technology. ADCETRIS is approved in certain CD30-expressing lymphomas, and PADCEV is EMPLOYEES: 2,200+ employees approved in certain metastatic urothelial cancers. TUKYSA® (tucatinib), a small mole- worldwide cule tyrosine kinase inhibitor, is approved in certain HER2-positive metastatic breast cancers. The company is headquartered in Seattle, Washington area, with loca- PASSION: Helping people with cancer tions in California, Switzerland and the European Union. Beyond our approved prod- ucts, the company has established a pipeline of novel targeted therapies at various stages of clinical testing. OUR MISSION OUR VALUES To discover, develop, and Passion for helping patients commercialize transformative cancer Revolutionizing therapies for people medicines to make a meaningful living with cancer difference in people’s lives. Integrity Honesty, respect and trust guide us Scientific excellence Premier science empowers our passion We have built a strong Diversity, teamwork, and corporate culture around our mutual respect mission and values. Seagen Shared dedication and diverse embodies an entrepreneurial perspectives drive successful spirit that advances collaborations breakthrough therapies, Innovation which is why we are the Entrepreneurial spirit advances leader in antibody-drug breakthrough therapies conjugate technology. -
EXELON CORPORATION EMPLOYEE SAVINGS PLAN (Full Title of the Plan)
Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K ☒ ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended December 31, 2007 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 1-16169 EXELON CORPORATION EMPLOYEE SAVINGS PLAN (Full title of the Plan) EXELON CORPORATION (a Pennsylvania Corporation) 10 South Dearborn Street P.O. Box 805379 Chicago, Illinois 60680-5379 (312) 394-7398 (Name of the issuer of the securities held pursuant to the Plan and the address of its principal executive offices) Table of Contents EXELON CORPORATION EMPLOYEE SAVINGS PLAN INDEX TO FORM 11-K Page No. Report of Independent Registered Public Accounting Firm 1 Financial Statements: Statements of Net Assets Available for Benefits as of December 31, 2007 and 2006 2 Statement of Changes in Net Assets Available for Benefits for the Year Ended December 31, 2007 3 Notes to Financial Statements 4 - 13 Supplemental Schedule: Schedule of Assets (Held at End of Year) as of December 31, 2007, Schedule H, Part IV, Item 4i of Form 5500 14 Note: All other schedules of additional information required by the Department of Labor’s Rules and Regulations for Reporting and Disclosure under ERISA have been omitted because they are not applicable. Exhibit Index 15 Signatures 16 Exhibits 17 Table of Contents REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM To the Participants and the Administrator of the Exelon Corporation Employee Savings Plan: We have audited the accompanying statements of net assets available for benefits of the Exelon Corporation Employee Savings Plan (the “Plan”) as of December 31, 2007 and 2006, and the related statement of changes in net assets available for benefits for the year ended December 31, 2007. -
FTIF - Franklin Global Growth Fund August 31, 2021
FTIF - Franklin Global Growth Fund August 31, 2021 FTIF - Franklin Global Growth August 31, 2021 Fund Portfolio Holdings The following portfolio data for the Franklin Templeton funds is made available to the public under our Portfolio Holdings Release Policy and is "as of" the date indicated. This portfolio data should not be relied upon as a complete listing of a fund's holdings (or of a fund's top holdings) as information on particular holdings may be withheld if it is in the fund's interest to do so. Additionally, foreign currency forwards are not included in the portfolio data. Instead, the net market value of all currency forward contracts is included in cash and other net assets of the fund. Further, portfolio holdings data of over-the-counter derivative investments such as Credit Default Swaps, Interest Rate Swaps or other Swap contracts list only the name of counterparty to the derivative contract, not the details of the derivative. Complete portfolio data can be found in the semi- and annual financial statements of the fund. Security Security Shares/ Market % of Coupon Maturity Identifier Name Positions Held Value TNA Rate Date G6095L109 APTIV PLC 70,000 $10,653,300 3.09% N/A N/A 045327103 ASPEN TECHNOLOGY INC 58,000 $7,511,000 2.18% N/A N/A BRIGHT HORIZONS FAMILY SOLUTIONS 109194100 49,000 $7,142,240 2.07% N/A N/A INC BROADRIDGE FINANCIAL SOLUTIONS 11133T103 46,000 $7,922,120 2.30% N/A N/A INC 124765108 CAE INC 360,000 $10,394,547 3.01% N/A N/A CHARLES RIVER LABORATORIES 159864107 27,000 $11,984,220 3.47% N/A N/A INTERNATIONAL -
Attribution Report
Quarterly Review As of 06/30/2021 MassMutual Equity Opportunities Fund* Wellington Management Company LLP | T. Rowe Price & Associates, Inc. I SHARE CLASS TICKER: MFVZX Fund Objective: This Fund seeks growth of capital over the long-term. Sector Weightings: Defines what % of each sector this fund holds Portfolio Attribution: Describes how fund manager sector and stock compared to its benchmark listed here. weighting decisions affected returns. Fund Russell 1000® Index QTD YTD 30 1 20 0 10 -1 Percent of Portfolio Value Added vs. Benchmark (%) 0 -2 Cash Cash Utilities Utilities Energy Energy Materials Materials Financials Financials Industrials Industrials Real Estate Real Estate Health Care Health Care Comm. Services Comm. Services Consumer Discr. Consumer Discr. Information Tech. Information Tech. Consumer Staples Consumer Staples Sector Attribution Details: Quarterly Portfolio Commentary: Sector Fund Weight QTD YTD Communication Services 1.43 -0.32 -0.49 Laurie Goodreau, CFA Investment Director Consumer Discretionary 10.11 -0.07 -0.56 Investment Experience: 30 Years Consumer Staples 16.85 -0.21 -1.20 Energy 1.79 -0.20 -0.55 Financials 17.39 0.40 0.74 HIGHLIGHTS • The Russell 1000 Index outpaced all three Russell value indexes and its Health Care 17.40 -0.71 -0.52 lower capitalization indexes in core while trailing the Russell 1000 Industrials 13.20 -0.05 -0.23 Growth and the Russell Mid-Cap Growth Indexes. Information Technology 7.77 -0.66 0.33 • All economic sectors of the Index delivered positive absolute returns except the utility sector. Materials 4.12 -0.12 -0.25 • Sector allocation was negative due to an overweight to consumer Real Estate 3.20 0.07 0.12 staples and an underweight to information technology. -
Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund a (Acc) USD This Fund Is Managed by Franklin Templeton International Services S.À R.L
31 May, 2021 Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD This fund is managed by Franklin Templeton International Services S.à r.l. EFC Classification Equity Biotechnology Price +/- Date 52wk range 40.80 EUR 0.13 28/05/2021 36.82 50.31 Issuer Profile Administrator Franklin Templeton International Services S.à r.l. The Fund aims to achieve capital appreciation by investing principally in equity securities Address 8A, rue Albert Borschette 1246 of biotechnology companies and discovery research firms mainly located in the US. City Luxembourg Tel/Fax +352 46 66 67 212 Chart 5 year Website www.franklintempleton.lu General Information ISIN LU0109394709 Fund Type Capitalization 50 Quote Frequency daily Quote Currency USD 45 Currency USD Foundation Date 03/04/2000 40 Fund Manager Wendy Lam Legal Type Investment company according to Luxembourg law 35 UCITS Yes Financial Year End 30/06/2020 30 Fund size 1,786,183,025.88 USD Minimal Order 5,000.00 USD 25 Costs 20 Entry fee 5.75 % 2017 2018 2019 2020 2021 Infront Finance Exit fee 0.00 % 38 Days 200 Days Operation costs 1.50 % Ongoing charges 1.83 % Fund Returns 2016 2017 2018 2019 2020 2021 Returns -15.18 2.77 -12.34 36.10 16.74 -8.55 Category Average Category Ranking / / / / / / 40 20 s e u l a V 0 -20 2016 2017 2018 2019 2020 2021 Returns Category Average Fund Ratios (end previous month) Timing YTD 1 month 6 months 1 year 3 year 5 year Performance Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD -4.26 % 0.75 % 10.52 % 23.66 % 12.07 % 10.78 % Volatility Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD 15.27 % 22.74 % 21.59 % 31 May, 2021 Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD This fund is managed by Franklin Templeton International Services S.à r.l. -
Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund a (Acc) USD This Fund Is Managed by Franklin Templeton International Services S.À R.L
22 February, 2021 Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD This fund is managed by Franklin Templeton International Services S.à r.l. EFC Classification Equity United States Health Care Price +/- Date 52wk range 48.62 EUR 0.68 19/02/2021 26.23 50.31 Issuer Profile Administrator Franklin Templeton International Services S.à r.l. The Fund aims to achieve capital appreciation by investing principally in equity securities Address 8A, rue Albert Borschette 1246 of biotechnology companies and discovery research firms mainly located in the US. City Luxembourg Tel/Fax +352 46 66 67 212 Chart 5 year Website www.franklintempleton.lu General Information ISIN LU0109394709 Fund Type Capitalization 50 Quote Frequency daily Quote Currency USD 45 Currency USD Foundation Date 03/04/2000 40 Fund Manager Wendy Lam Legal Type Investment company according to Luxembourg law 35 UCITS Yes Financial Year End 30/06/2020 30 Fund size 1,605,796,760.42 USD Minimal Order 5,000.00 USD 25 Costs 20 Entry fee 5.75 % 2017 2018 2019 2020 2021 Infront Finance Exit fee 0.00 % 38 Days 200 Days Operation costs 1.00 % Ongoing charges 1.83 % Fund Returns 2016 2017 2018 2019 2020 2021 Returns -15.18 2.77 -12.34 36.10 16.74 9.00 Category Average -7.83 7.56 1.62 26.74 12.02 4.75 Category Ranking 215 / 251 238 / 288 303 / 319 34 / 384 102 / 443 68 / 508 40 20 s e u l a V 0 -20 2016 2017 2018 2019 2020 2021 Returns Category Average Fund Ratios (end previous month) Timing YTD 1 month 6 months 1 year 3 year 5 year Performance Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD 0.22 % 0.22 % 13.91 % 34.21 % 10.46 % 12.16 % Volatility Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD 22.42 % 22.76 % 21.80 % 22 February, 2021 Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD This fund is managed by Franklin Templeton International Services S.à r.l. -
Federated Hermes Kaufmann Large Cap Fund
Federated Hermes Kaufmann Large Cap Fund 6/30/21 Fund description The fund seeks to provide capital appreciation by investing primarily in securities of large-cap companies. Utilizing an intensive, bottom-up security selection process, the fund focuses on companies that exhibit Fund facts positive growth characteristics. Performance inception date Average annual total returns (%) Performance shown is before tax. 12/5/07 Expense ratio* Since Before After Benchmark 3-month YTD 1-year 3-year 5-year 10-year inception waivers waivers Russell 1000® Growth Index R6 Shares 11.44 8.77 30.55 21.52 20.24 16.28 13.08 0.87 0.78 Morningstar category Institutional Shares 11.45 8.73 30.45 21.43 20.17 16.23 13.23 0.93 0.84 Large Growth A Shares (NAV) 11.36 8.57 30.11 21.13 19.86 15.94 12.94 1.18 1.09 Lipper classification A Shares (MOP) 5.24 2.61 22.96 18.87 18.52 15.28 12.47 1.18 1.09 Multi-Cap Growth Funds Benchmark 11.93 12.99 42.50 25.14 23.66 17.87 – – – Fund assets 50 $4.6 billion 42.50 41.70 Ticker symbols 40 R6 Shares - KLCSX 30.45 30 25.14 23.66 Institutional Shares - KLCIX 22.56 21.98 21.43 20.17 17.87 A Shares - KLCAX 20 16.23 15.99 Total returns (%) 11.93 C Shares - KLCCX 11.45 10.28 10 R Shares - KLCKX Key investment team 0 Hans Utsch 3-month 1-year 3-year 5-year 10-year Tom Brakel, M.D.