bioRxiv preprint doi: https://doi.org/10.1101/2020.08.27.269795; this version posted August 28, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Manuscript BioRxiv Investigation of anti-IgLON5-induced neurodegenerative changes in human neurons Mattias Gamre1,2, Matias Ryding1,2, Mette Scheller Nissen1,2,3, Anna Christine Nilsson4, Morten Meyer1,2,5, Morten Blaabjerg1,2,3,5 1Neurobiological Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. 2Department of Neurology, Odense University Hospital, Odense, Odense, Denmark 3Department of Clinical Research, Odense University Hospital, Odense, Denmark 4Department of Clinical Immunology, Odense University Hospital, Odense, Denmark 5BRIDGE – Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark Number of pages: 12 Number of figures: 4 Keywords: IgLON5, Autoimmune encephalitis, neurodegeneration, inflammation, Tau Corresponding author Professor Morten Blaabjerg, MD, PhD Department of Neurology Odense University Hospital J.B. Winsløws Vej 4 5000 Odense C Denmark Phone: (+45) 6541 2457 E-mail:
[email protected] Page 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.08.27.269795; this version posted August 28, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license.