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Rediscovering the Art
Rediscovering the art 18 Current VOL. 1, NO. 12 / DECEMBER 2002 p SYCHIATRY Current p SYCHIATRY of lithium therapy James W. Jefferson, MD s a mood stabilizer for patients with bipo- Distinguished senior scientist lar disorder, lithium was the darling of Madison Institute of Medicine, Inc. U.S. psychiatry from the 1970s to well into the 1990s. It then began an ill-deserved, gradual fall from Clinical professor of psychiatry A grace and today could be considered a pharmaceutical University of Wisconsin Medical School endangered species. But why? Did lithium lose effectiveness? Is it too toxic? Is its side effect burden too heavy? Does it interact adversely with too many medicines? Is it too cumbersome to use? Was it just a Lithium is not a fad whose time came fad whose time came and went—a psychiatric pet rock? Did it fall prey to the marketing might behind patent-protected and went. It is a valuable medication drugs? Was it replaced by more effective and safer drugs? You are partially correct if you checked “all of the that belongs in our arsenal for bipolar above,” because all contain a kernel of truth. At the same disorder. time, each is an exaggeration that does grave injustice to a remarkable medication. In addition, psychiatry appears to pay only lip service to convincing evidence that lithium is the only mood stabilizer that reduces the risk of suicide during long-term treatment.1 Some psychiatrists rationalize that “lithium is too diffi- cult to use, so I never prescribe it.”2,3 My response is simply, “try it, and I think you’ll like it.” Measuring serum lithium concentrations is simple, accurate, and inexpensive. -
Theory of Mind Deficit in the Behavioral Variant of Frontotemporal Dementia and in Amyotrophic Lateral Sclerosis: Why Does It Matter?
Open Access Journal of Neurology & Neurosurgery Editorial Open Access J Neurol Neurosurg Volume 1 Issue 1 - December 2015 Copyright © All rights are reserved by Marco Cavallo Theory of Mind deficit in the behavioral variant of frontotemporal dementia and in amyotrophic lateral sclerosis: Why does it matter? Marco Cavallo1,2* 1eCampus University, Novedrate (Como), Italy 2Mental Health Department - Azienda Sanitaria Locale Torino 3, Italy Submission: November 15, 2015; Published: December 02, 2015 *Corresponding author: Marco Cavallo, Neuropsychologist, Researcher at the faculty of Psychology of the eCampus University of Novedrate, Italy, Tel no: +39.3478306430; Email: Editorial stories that explicitly referred to social situations. Our results underlined the needs for further research to gain a deeper Theory of Mind (hereinafter referred to as ToM) is the ability understanding on the possible link between patient’s behavioral to explain and predict other people’s behavior by attributing problems and their limited understanding of social situations. independent mental states to them. It allows us to recognize that mental states such as beliefs, intentions, and desires play a key role in driving and monitoring human behavior. Impairment in associated with ALS, a neurodegenerative disease that from We also aimed at clarifying the nature of the ToM deficits ToM ability can be highly disabling. ToM had been extensively cognitive and neuroimaging points of view appears to share studied in neuropsychiatric conditions such as autism and some relevant -
Social Behaviour Vs. Psychiatric Features Of
Psychiatria Danubina, 2010; Vol. 22, No. 2, pp 179–182 Case report © Medicinska naklada - Zagreb, Croatia SOCIAL BEHAVIOUR VS. PSYCHIATRIC FEATURES OF FRONTOTEMPORAL DEMENTIA Clinical report of two cases Rajka Marija Liščić1 & Aleš Kogoj2 1Institute for Medical Research and Occupational Health, Zagreb, Croatia 2Department of Geriatric Psychiatry, University Psychiatric Hospital, Ljubljana, Slovenia received: 6.10.2009; revised: 12.1.2010; accepted: 9.2.2010 SUMMARY Behavioural disturbances are prominent in frontotemporal dementia (FTD), a focal, non-Alzheimer type of dementia. Although most patients with FTD present with socially inappropriate behaviour, compulsive-like acts, poor insight and disinhibition, the presence of psychiatric features including delusions, hallucinations, and paranoia can lead to a misclassification of FTD as psychiatric disorder. In the absence of cognitive deficits non-experts fail to recognize these social changes as dementia symptoms. We report two individuals who met current clinical criteria for behavioural or frontal variant FTD (bv-FTD), with the aim of distinguishing between psychotic symptoms and the often bizarre personality and behaviour change found in FTD. Also we review the literature on the noncognitive neuropsyhiatric manifestation of this disorder. Clinical findings presented, and a literature review, indicate that psychotic symptoms are rare in FTD. Better awareness of behavioural symptoms in clinical practice is necessary in order to avoid misdiagnosis of FTD as psychiatric disorder. Key words: bv-frontotemporal dementia - behavioural disturbances - psychotic symptoms * * * * * INTRODUCTION and paranoia) must be distinguished from the often bizarre personality and behaviour changes of FTD. The With baby boomers now reaching late middle age, overlap between FTD and psychotic symptoms exists degenerative diseases are becoming an increasingly and therefore may lead to misleading diagnoses. -
The Dual Effect of Lithium on Inflammatory Bowel Disease and Bipolar Disorder: a Review
ISSN: 2638-3535 Madridge Journal of Clinical Research Review Article Open Access The Dual Effect of Lithium on Inflammatory Bowel Disease and Bipolar Disorder: A Review Gabriel DeSouza, Halford G Warlick IV, and Vincent S Gallicchio* Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA Article Info Abstract *Corresponding author: Lithium has been the gold standard for treatment of bipolar disorder since the mid- Vincent S Gallicchio 20th century. Lithium, at low doses, gained popularity as the first-line treatment of this Department of Biological Sciences disorder. Eventually, lithium became part of many successful treatment plans for bipolar 122 Long Hall Clemson University and depressed patients, leading to more focused research on basic and applied Clemson, South Carolina pharmacological effects of this drug. However, the evidence that lithium can reduce USA inflammation by inhibiting glycogen synthase kinase 3 – beta (GSK3β) enzyme which is E-mail: [email protected] linked to autoimmune and inflammatory disorders, and cancer is still emerging. Therefore, this review examines whether inflammatory conditions such as Inflammatory Received: April 19, 2019 Accepted: November 27, 2019 Bowel Disease (IBD) have a higher occurrence rate of mental illness in comparison to the Published: December 6, 2019 population presenting with IBD without the co-pathology of mental illness. This investigation explored lithium’s beneficial effects in IBD when evaluated either in animal Citation: DeSouza G, Warlick IV HG, models or in IBD patients with or without chronic mental illness. Further research must Gallicchio VS. The Dual Effect of Lithium on be conducted to evaluate for significant evidence of its antipsychotic and anti- Inflammatory Bowel Disease and Bipolar Disorder: A Review. -
Use of Antipsychotic Drugs and Lithium in Mania
BRITISHJOURNAL OF PSYCHIATRY %20%2001), 01), 178 %suppl. 41), s14s148^ 8^ s156 Use of antipsychotic drugs and lithium in mania experience over the following 30 years indi- cated that lithium is far short of an ideal treatment, even when administered expertly JOHN COOKSON to `concordant' patients. There is a striking difference between the results of early con- trolled trials and the outcome on lithium in open clinical practice, where a smaller pro- portion of patients appear to be `lithium re- sponders'; some even doubt the validity of the clinical trials %Moncrieff, 1997). The benefits of lithium therapy have to be balanced against the difficulties in its Background Studies highlighting the Mania or a manic episode is a severe phase management ± with poor compliance in pa- difficulties associated withlithium suggest in the course of bipolar disorders, the con- tients with bipolar disorder and the occur- dition termed `manic±depressive illness' by rence of withdrawal mania ± and the risks that the role of antipsychotic drugs and Kraepelin in the 19th century. A contem- of side-effects and toxicity %Cookson, mood stabilisersin bipolardisorder should porary textbookdescribed the difficulty of 1997). The latter includes the possibility be reconsidered. managing a patient with mania ± using of permanent neurological sequelae with drugs of limited efficacy, mainly sedative cerebellar damage %Schou, 1984). Aims Toreview the efficacyandmode or anaesthetic, such as chloral and ur- Since the 1970s anticonvulsant drugs, of action of antipsychotic drugsin mania, ethane, or potentially toxic drugs, such as first carbamazepine and more recently and to consider the differences between potassium bromide. The sedative anticon- valproate and, in open studies, lamotrigine officialguidelines and routine clinical vulsant paraldehyde was also used. -
Psychotic Symptoms in Frontotemporal Dementia: a Diagnostic Dilemma?
International Psychogeriatrics (2015), 27:4, 531–539 C International Psychogeriatric Association 2014. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. doi:10.1017/S1041610214002580 Psychotic symptoms in frontotemporal dementia: a diagnostic dilemma? ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Maria Landqvist Waldö,1 Lars Gustafson,1 Ulla Passant1 and Elisabet Englund2 1Section of Geriatric Psychiatry, Department of Clinical Sciences, Lund University, Klinikgatan 22, Lund SE-221 85, Sweden 2Section of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, SE-221 85, Sweden ABSTRACT Background: Frontotemporal dementia (FTD) constitutes a spectrum of neurodegenerative disorders associated with degeneration of, predominantly, -
The Road from Estrangement to Reconciliation
The Road From Estrangement to Reconciliation The Road from Estrangement to Reconciliation 15 Week Program Participant Name: ___________________________________ Date: _____________________________________________ Twitter: https://twitter.com/#!/Gatehouse_The Facebook: https://www.facebook.com/TheGatehouseChildAbuseInvestigationSupportSite YouTube: https://www.youtube.com/user/GatehouseThe?feature= Instagram: @thegatehousetoronto 1 The Road From Estrangement to Reconciliation Contents WEEK ONE – The Road From Estrangement to Reconciliation ............................................................................. 4 Introduction ............................................................................................................................................................. 5 4 Possible Outcomes .............................................................................................................................................. 5 The Pain of Estrangement ..................................................................................................................................... 6 The Roots of Estrangement................................................................................................................................... 6 Embracing Paradox ................................................................................................................................................. 7 WEEK TWO: Building a Self: The Importance of Autonomy ................................................................................ -
The ICD-10 Classification of Mental and Behavioural Disorders : Clinical Descriptions and Diagnostic Guidelines
ICD-10 ThelCD-10 Classification of Mental and Behavioural Disorders Clinical descriptions and diagnostic guidelines | World Health Organization I Geneva I 1992 Reprinted 1993, 1994, 1995, 1998, 2000, 2002, 2004 WHO Library Cataloguing in Publication Data The ICD-10 classification of mental and behavioural disorders : clinical descriptions and diagnostic guidelines. 1.Mental disorders — classification 2.Mental disorders — diagnosis ISBN 92 4 154422 8 (NLM Classification: WM 15) © World Health Organization 1992 All rights reserved. Publications of the World Health Organization can be obtained from Marketing and Dissemination, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel: +41 22 791 2476; fax: +41 22 791 4857; email: [email protected]). Requests for permission to reproduce or translate WHO publications — whether for sale or for noncommercial distribution — should be addressed to Publications, at the above address (fax: +41 22 791 4806; email: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. -
Intergenerational Estrangement Between Older Parents And
Every family: Intergenerational estrangement between older parents and their adult-children Kylie Beth Agllias BSW (Hons), UoN, AUST. A thesis submitted for the degree of Doctor of Philosophy (Social Work) University of Newcastle School of Humanities and Social Science May 2011 Declaration This thesis contains no material which has been accepted for the award of any other degree or diploma in any university or other tertiary institution and, to the best of my knowledge and belief, contains no material previously published or written by another person, except where due reference has been made in the text. I give consent to this copy of my thesis, when deposited in the University Library, being made available for loan and photocopying subject to the provisions of the Copyright Act 1968. Signed:............................................................. Date:.................................................. i Acknowledgements A mind that is stretched to a new idea never returns to its original dimension (Oliver W. Holmes) Some suggest the proof of a good thesis is when the examiner knows the student learnt something. However, the main lessons are the ones witnessed by supervisors, family, and friends, the lessons most often excluded from the text. I would like to thank the following people who witnessed and supported my doctoral journey and the associated life lessons: To my doctoral supervisors, mentors and colleagues, Professor Mel Gray and Doctor Jill Gibbons, I cannot thank you enough for your encouragement, guidance, and faith. You ‘saw me’ well before I knew myself. To my wonderfully generous, loving, amusing, and busy family, James, Kara, Paige, and Tyson, I love you. You are my world. -
Adult Child-Parent Relationships: Predicting Physical and Emotional Estrangement
Adult Child-Parent Relationships: Predicting Physical and Emotional Estrangement Brianne Pragg Penn State University Abstract It is often assumed that the relationship between parents and children are involun- tary and stable throughout the life course. However, a growing literature on the estrangement of adult children from their parents finds that this is not always the case. The current study uses Waves I – IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine the predictors of different dimensions of adult child-parent estrange- ment. Physical and emotional estrangement are rarely considered separately in quantitative studies, but this study will explore these dimensions of estrangement separately and con- sider whether the predictors vary between types of estrangement and by gender of both the children and the parents. Acknowledgements This research was supported by funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development to the Population Research Institute at The Pennsylvania State University for Population Research Infrastructure (R24HD041025) and Family Demography Training (T-32HD007514). 1 It is often assumed that parents and their children have unconditionally supportive relationships throughout the life course. However, studies on intergenerational relationships have found that the relationships between parents and their adult children are not always positive (Blake 2017). A growing literature on parent-child estrangement has found that some relationships between adult parents and their children are physically and/or emotion- ally distant, and others are dissolved entirely (Blake 2017). Depending on the measure or typology of estrangement used, studies estimate that between four and 27 percent of adult children report having strained relationships or no contact with their parents, making it a fairly common occurance over the life course (Agllias 2017; Gilligan et al. -
Early-Onset Parkinson's Disease Caused by PLA2G6 Compound
CASE REPORT published: 21 August 2019 doi: 10.3389/fneur.2019.00915 Early-Onset Parkinson’s Disease Caused by PLA2G6 Compound Heterozygous Mutation, a Case Report and Literature Review Ting Shen 1,2,3, Jing Hu 1,2, Yasi Jiang 2,3, Shuai Zhao 1,2, Caixiu Lin 1,2, Xinzhen Yin 1,2, Yaping Yan 1,2, Jiali Pu 1,2, Hsin-Yi Lai 2,3* and Baorong Zhang 1,2* 1 Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China, 2 Department of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University, Hangzhou, China, 3 Key Laboratory of Biomedical Engineering of Ministry of Education, Qiushi Academy for Edited by: Advanced Studies, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China Ruey-Meei Wu, National Taiwan University, Taiwan Reviewed by: PLA2G6 has been certified as a causative gene in patients with autosomal recessive Yih-Ru Wu, early-onset Parkinson’s disease (EOPD). We reported an EOPD case caused by Chang Gung Memorial Hospital, Taiwan PLA2G6 gene mutation, and performed neurological examination, genetic analysis, Chin-Hsien Lin, and multimodal neuroimaging to describe this phenotype. A compound heterozygous National Taiwan University, Taiwan mutation c.991G>T/c.1472+1G>A was detected in this patient. Heterozygous for the *Correspondence: c.991G>T and c.1472+1G>A were separately detected in his parents. Pathogenicity Hsin-Yi Lai [email protected] of these two mutations were predicted according to the American college of medical Baorong Zhang genetics and genomics (ACMG) guideline. -
Schizophrenia and Frontotemporal Dementia: Shared Causation?
International Review of Psychiatry, April 2013; 25(2): 168–177 Schizophrenia and frontotemporal dementia: Shared causation? MICHA Ł HARCIAREK 1 , DOLORES MALASPINA2 , TAO SUN3 & ELKHONON GOLDBERG4 1 Division of Clinical Psychology and Neuropsychology, Institute of Psychology, University of Gdansk, Poland, 2 Department of Psychiatry, New York University School of Medicine, New York, USA, 3 Department of Cell and Developmental Biology, Cornell University Weill Medical College, New York, USA, 4 Department of Neurology, New York University School of Medicine, New York, USA Abstract The relationship between specifi c genes and particular diseases in neuropsychiatry is unclear, and newer studies focus on shared domains of neurobiological and cognitive pathology across different disorders. This paper reviews the evidence for an association between schizophrenia and frontotemporal dementia, including symptom similarity, familial co-morbidity, and neuroanatomical changes. Genetic as well as epigenetic fi ndings from both schizophrenia and frontotemporal demen- tia are also discussed. As a result, we introduce the hypothesis of a shared susceptibility for certain subgroups of schizo- phrenia and frontotemporal dementia. This common causation may involve the same gene(s) at different stages of life: early in schizophrenia and late in frontotemporal dementia. Additionally, we provide a rationale for future research that should emphasize both genetic and cognitive parallels between certain forms of schizophrenia and frontotemporal dementia in a synergistic, coordinated way, placing both in the context of aberrant lateralization patterns. Introduction of what constitutes a ‘ disorder ’ in neuropsychiatry, The relationship between specifi c genes and particu- and invited the revision of, and departure from, tra- lar diseases in neuropsychiatry remains unclear, and ditional diagnostic taxonomies.