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Guidebook for the Synthesis of Oligonucleotides Product Guide 2015/16 Guidebook for the Synthesis of Oligonucleotides Product Guide 2015/16 www.linktech.co.uk | +44 (0) 1698 849911 | [email protected] Don’t let paperwork Synthesis of oligonucleotides is Opening an online account with LINK is slow down the real complicated enough without the chore easy – and you can place your first order work. of ordering reagents getting in the way. in minutes. Popular products are always Buying oligo reagents from LINK is held in stock, ensuring a fast and Order reagents in simple and straightforward. In the time reliable turnaround from order to seconds for next-day it takes to download a couple of music delivery. And, for many common tracks online, you could be sorted for products, highly attractive multi-pack delivery. next-day delivery, anywhere in mainland discounts are available immediately Europe. online – there’s no need to request a Our extensive catalogue of products for quote. the synthesis of oligonucleotides All of which leaves you to concentrate (including DNA, RNA, PNA and UNA on making your oligos. While we products) has all the reagents you need. concentrate on making your life easier. What’s more, our quality control ensures impeccable consistency of product. Find out more: www.linktech.co.uk | +44 (0) 1698 849911 | [email protected] Guidebook for the Synthesis of Oligonucleotides Product Guide 2015/16 © 2015 Link Technologies Ltd. Unless otherwise specified, no content from this document may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without the prior written permission of Link Technologies Ltd. LINK is a trading name of Link Technologies Ltd. Version 1.2 (16 March 2015) distributed by PDF only. All content was correct at the time of writing, however may be subject to change without notice. Please check www.linktech.co.uk for any updated versions and/or to request a paper copy when available. At LINK, we work to one standard. We manufacture reagents for As one of the biggest specialist oligonucleotide synthesis to an companies in our field, we ensure great And that’s unrivalled level of quality. We control value for money. and check the whole manufacturing exceptional. Our team is made up of passionate, process, repeatedly, at every stage. We committed professionals who deliver put 25 years’ experience in chemistry - the most efficient, helpful service you in particular with respect to oligo could imagine. And don’t just take our synthesis reagents - at your disposal, word for it: when we asked our and whether you want 1g or 1kg, we’re customers to rate our service, the with you all the way. average score was a rather impressive We combine a comprehensive 9.3 out of 10 (we’re working on the catalogue of off-the-shelf materials other 0.7). together with a full bespoke service If it says LINK on the label, you know – including our specification-tailored you can trust it. LINK+ reagents – so you can order precisely what you need, every time. A little bit of history... quality products therefore our QC processes allow for testing of all key raw materials and LINK began operations in 1989 in all intermediates in addition to our final laboratories within Glasgow University products. After QC all batches undergo QA with an initial emphasis on the provision review prior to release. of reagents for DNA synthesis. In 1992 the Company expanded to occupy custom- equipped laboratories in Cumbernauld near Facilities Glasgow. In 2000 we moved to newly-built premises at the Strathclyde Business Park in LINK operates from a single 7500 sq. ft. central Scotland, where we are still located. custom-built facility in central Scotland. In 2008 the upgrading of these facilities to Initially the Company operated primarily as include two large-scale laboratories was a contract manufacturer with a number of completed, giving the company the ability key clients, however in 2001 we launched to manufacture from small, development our first catalogue of reagents offering our scale right up to the kilo scale to meet our manufactured products direct to customers. customers’ growing needs. Since then the catalogue has grown to hundreds of products, many of them unique Our QC operation, and associated QA to us, whilst our custom and contract quarantine areas, are housed in defined business goes from strength to strength. areas of the facility separate from process development and routine manufacturing. Throughout this expansion, the Company goal has remained the same: to provide the Not only do we have a wide variety of in- unique link between scientists working in house analytical techniques such as HPLC, the life sciences and the chemical tools and LCMS-TOF and UV/vis, we also work with technologies that they require. Such a bridge external partners to provide e.g. NMR and forms the basis of the multi-disciplinary fluorescence measurement, enabling us approach vital to the growing biotechnology to fully characterise and analyse all our industry. products, intermediates and raw materials. All our oligonucleotide synthesiser reagents LINK now boasts a strong portfolio of joint- products are functionally tested on one venture development projects and research of our in-house oligo synthesisers and the collaborations with a number of companies resulting oligo subsequently analysed. and research institutions worldwide. Society & the environment Our quality guarantee At LINK we are very much aware of our At LINK, we are very customer focused responsibility to the environment and and strive to not only meet but exceed consider the impact of our operations the requirements and expectations of our on society very seriously. We strive to customers. As a measure of this, our Quality minimise our waste production and Management System (QMS) is certified to maximise recycling at all times - whether in ISO9001 standard. our laboratories, canteen, or paper for our marketing materials. While continuing to provide robust and reliable service and products, we are Of course, chemical production will always committed to continual improvement and produce waste but we always ensure that the as such once an improvement project has hazardous material element of what waste been determined, we put together Continual we do produce is properly contained and Improvement Groups consisting of key dealt with responsibly. people to work on the project. Many of these project ideas come from the customer. In We also have an annual charities budget that conjunction with our QMS, our Customer supports charitable organisations chosen Relationship Management (CRM) System by our staff, including Cancer Research UK allows all customer contact (sales, enquiries, (www.cancerresearchuk.org), and, locally, technical support) to be monitored as a the Scottish Centre for Children with Motor means of identifying trends which allows us Impairments (www.craighalbert.org.uk). to act faster in terms of any changes that may be required as a result of a trend, e.g. scale up of a particular product. This then becomes a continual improvement project. Clearly LINK is committed to providing high We just love a demanding At LINK, our catalogue range of oligo the option for custom and bulk reagents is exceptional. But it may not packaging, as well as scheduled customer. be enough for our more specialist deliveries. clients. You know who you are – CMOs, LINK+ reagents take high-end That’s precisely why GMP manufacturers, diagnostic oligo specification to a whole new level. A manufacturers and others. LINK+ evolved. LINK+ product has a base specification You may work to ISO 13485, but you’re set at the highest available on the certainly a customer with highly market, but we’ll adapt it to exactly what specialised, possibly unique, you need – using your test methods if requirements. You need a partner you that’s what you want. We’ll supply a can trust to deliver the highest quality comprehensive analytical report, products, to your exacting standard, via including impurity profiling. And as a managed supply chain. you’d expect, at LINK we’re certified to ISO 9001. Our LINK+ service has been designed just for you. It brings you enhanced So be as demanding as you like. We’ll specification, scaled manufacturing and rise to the challenge. LINK+ reagents Scaled manufacturing Through working with several key clients, LINK’s facilities give us the capability to we have begun the creation of the LINK+ manufacture from the small research gram range of products. These have a high-grade scale right up to kilo scale batches for minimum specification, however this can be commercial manufacture. Other suppliers further customised to your requirements if can offer either end of that spectrum but necessary. Through continued consultation very few can do both. Through tested with customers we will add to this range of process optimisation methods we can scale products over time. Full specifications are up our production, taking your product from available on request, however the headline initial testing right up to early phase clinical values are shown on our website at trials of the oligonucleotide, thus providing www.linktech.co.uk/linkplus. the essential continuity of your supply chain through these stages. Ordering LINK+ reagents As these are specialised products, we Custom and bulk packaging normally manufacture to order therefore We take care to provide our off-the-shelf there will be a short lead time. Stocks are not products in popular pack sizes and packing held in the same way as regular catalogue formats. As your needs grow so do the products, although we do hold residual options available to you. We can supply any stock where appropriate. Pack sizing and manufactured product in bulk quantities, pricing for LINK+ reagents is dependent on with a significant reduction in pricing/gram your specific requirements.
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