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Organic Synthesis Edited by Belakatte Parameshwarappa Nandeshwarappa The book ‘Organic Synthesis - A Nascent Relook’ is a compendium of the recent Organic Synthesis - A Nascent Relook progress in all aspects of organic chemistry including bioorganic chemistry, organo- metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product Organic Synthesis chemistry, catalytic, green chemistry and medicinal chemistry, polymer chemistry, as well as analytical methods in organic chemistry. The book presents the latest A Nascent Relook developments in these fields. The chapters are written by chosen experts who are internationally known for their eminent research contributions. Organic synthesis is the complete chemical synthesis of a target molecule. In this book, special emphasis is given to the synthesis of various bioactive heterocycles. Careful selection of various Edited by topics in this book will serve the rightful purpose for the chemistry community and Belakatte Parameshwarappa Nandeshwarappa the industrial houses at all levels. ISBN 978-1-78985-943-0 Published in London, UK © 2020 IntechOpen © nespix / iStock Organic Synthesis - A Nascent Relook Edited by Belakatte Parameshwarappa Nandeshwarappa Published in London, United Kingdom Supporting open minds since 2005 Organic Synthesis - A Nascent Relook http://dx.doi.org/10.5772/intechopen.83193 Edited by Belakatte Parameshwarappa Nandeshwarappa Contributors Tejpal Singh Chundawat, Naga Sesha Sai Pavan Kumar Chebolu, Yan-Chao Wu, Yun-Fei Cheng, Hui-Jing Li, Davor Margetić, Vjekoslav Štrukil, Badri Nath Jha, Abhinav Raghuvanshi, Nishant Singh, Vitaliy Viktorovich Libanov, Alevtina Anatol’evna Kapustina, Nikolay Pavlovich Shapkin, Tangali Ramanaik Ravikumar Naik, Andivelu Ilangovan, Adarsh Krishna Thumadath Palayullaparambil, Sakthivel Pandaram, Tamilselvan Duraisamy, Jamel Mejri, Youkabed Zarrouk, Majdi Hammami, David Joshua Ferguson © The Editor(s) and the Author(s) 2020 The rights of the editor(s) and the author(s) have been asserted in accordance with the Copyright, Designs and Patents Act 1988. All rights to the book as a whole are reserved by INTECHOPEN LIMITED. The book as a whole (compilation) cannot be reproduced, distributed or used for commercial or non-commercial purposes without INTECHOPEN LIMITED’s written permission. Enquiries concerning the use of the book should be directed to INTECHOPEN LIMITED rights and permissions department ([email protected]). Violations are liable to prosecution under the governing Copyright Law. Individual chapters of this publication are distributed under the terms of the Creative Commons Attribution 3.0 Unported License which permits commercial use, distribution and reproduction of the individual chapters, provided the original author(s) and source publication are appropriately acknowledged. If so indicated, certain images may not be included under the Creative Commons license. In such cases users will need to obtain permission from the license holder to reproduce the material. More details and guidelines concerning content reuse and adaptation can be found at http://www.intechopen.com/copyright-policy.html. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. First published in London, United Kingdom, 2020 by IntechOpen IntechOpen is the global imprint of INTECHOPEN LIMITED, registered in England and Wales, registration number: 11086078, 7th floor, 10 Lower Thames Street, London, EC3R 6AF, United Kingdom Printed in Croatia British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library Additional hard and PDF copies can be obtained from [email protected] Organic Synthesis - A Nascent Relook Edited by Belakatte Parameshwarappa Nandeshwarappa p. cm. Print ISBN 978-1-78985-943-0 Online ISBN 978-1-78985-944-7 eBook (PDF) ISBN 978-1-83880-626-2 We are IntechOpen, the world’s leading publisher of Open Access books Built by scientists, for scientists 4,800+ 123,000+ 135M+ Open access books available International authors and editors Downloads Our authors are among the 151 Top 1% 12.2% Countries delivered to most cited scientists Contributors from top 500 universities TE A NA A LY IV T R I A C L S C BOOK CITATION INDEX I N D E X E D Selection of our books indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI) Interested in publishing with us? Contact [email protected] Numbers displayed above are based on latest data collected. For more information visit www.intechopen.com Meet the editor Dr. Belakatte Parameshwarappa Nandeshwarappa holds an M.Sc. and Ph.D. from Kuvempu University, Karnataka, India. He was a Postdoral fellow at the Institute of Fine Chemicals, East China University of Science and Technology, Shanghai. He has published many scientific papers in peer-reviewed journals and presented his research papers at national and international conferences, seminars and workshops. He has edited five books, authored seven specialized books and five book chapters. His main areas of research are organic synthesis, process developments, and medicinal chemistry. He has guid- ed fifty-one dissertation theses for postgraduate students and is currently guiding Ph.D. students. He has fourteen years of teaching experience and three years of industry experience. Dr. Belakatte Nandeshwarappa received several awards such as young scientist, best poster presentation award in recognition for his outstanding contribution to education and research. He is currently working as an Asssociate Professor at DOS in the Chemistry Department, Davangere University, Davangere. Contents Preface III Section 1 Section A 1 Chapter 1 3 Design and Strategic Synthesis of Some β-Carboline-Based Novel Natural Products of Biological Importance by Tejpal Singh Chundawat Chapter 2 15 Synthesis of s- and p-Element Organosiloxanes by Mechanochemical Activation by Vitaliy Viktorovich Libanov, Alevtina Anatol’evna Kapustina and Nikolay Pavlovich Shapkin Chapter 3 27 Recent Advances in Mechanochemical Organic Synthesis by Davor Margetić and Vjekoslav Štrukil Chapter 4 51 Approaches to the Total Synthesis of Puupehenone-Type Marine Natural Products by Yan-Chao Wu, Yun-Fei Cheng and Hui-Jing Li Chapter 5 71 N,N-Dialkyl Amides as Versatile Synthons for Synthesis of Heterocycles and Acyclic Systems by Andivelu Ilangovan, Sakthivel Pandaram and Tamilselvan Duraisamy Section 2 Section B 105 Chapter 6 107 Synthetic Studies of Vitamin B12 by David Joshua Ferguson Chapter 7 125 C▬H Activation Strategies for Heterofunctionalization and Heterocyclization on Quinones: Application in the Synthesis of Bioactive Compounds by Andivelu Ilangovan and Thumadath Palayullaparambil Adarsh Krishna Contents Preface XIII Section 1 Section A 1 Chapter 1 3 Design and Strategic Synthesis of Some β-Carboline-Based Novel Natural Products of Biological Importance by Tejpal Singh Chundawat Chapter 2 15 Synthesis of s- and p-Element Organosiloxanes by Mechanochemical Activation by Vitaliy Viktorovich Libanov, Alevtina Anatol’evna Kapustina and Nikolay Pavlovich Shapkin Chapter 3 27 Recent Advances in Mechanochemical Organic Synthesis by Davor Margetić and Vjekoslav Štrukil Chapter 4 51 Approaches to the Total Synthesis of Puupehenone-Type Marine Natural Products by Yan-Chao Wu, Yun-Fei Cheng and Hui-Jing Li Chapter 5 71 N,N-Dialkyl Amides as Versatile Synthons for Synthesis of Heterocycles and Acyclic Systems by Andivelu Ilangovan, Sakthivel Pandaram and Tamilselvan Duraisamy Section 2 Section B 105 Chapter 6 107 Synthetic Studies of Vitamin B12 by David Joshua Ferguson Chapter 7 125 C▬H Activation Strategies for Heterofunctionalization and Heterocyclization on Quinones: Application in the Synthesis of Bioactive Compounds by Andivelu Ilangovan and Thumadath Palayullaparambil Adarsh Krishna Chapter 8 159 Total Synthesis of Macrolides Preface by Chebolu Naga Sesha Sai Pavan Kumar Chapter 9 181 Catalytic Activity of Iron N-Heterocyclic Carbene Complexes by Badri Nath Jha, Nishant Singh and Abhinav Raghuvanshi Organic synthesis remains one of the frontier challenges in organic chemistry and Chapter 10 207 drives quite an active area of research. It usually refers to a process not involving the Torrefaction of Sunflower Seed: Effect on Extracted Oil Quality aid of biological processes. by Jamel Mejri, Youkabed Zarrouk and Majdi Hammami The development of new synthetic methods for the preparation of organic mol- Chapter 11 217 ecules continues to be an active and exciting area of research in organic chemistry. Therapeutic Significance of 1,4-Dihydropyridine Compounds The discovery and application of new and interesting methods in organic synthesis as Potential Anticancer Agents is vital to the goals of designing shorter, more elegant, and ultimately more reliable by Tangali Ramanaik Ravikumar Naik syntheses of novel heterocycles and natural products. Organic synthesis is the com- plete chemical synthesis of a complex molecule, very often organic molecules, from simple, commercially available precursors. As a scientific discipline, these kinds of synthesis have their formative roots in organic chemistry. The synthesis of hetero- cycles continues
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