DOCSLIB.ORG

(12) Patent Application Publication (10) Pub. No.: US 2016/0022579 A1 Siegfried (43) Pub

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) Patent Application Publication (10) Pub. No.: US 2016/0022579 A1 Siegfried (43) Pub US 20160022579A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0022579 A1 Siegfried (43) Pub. Date: Jan. 28, 2016 (54) LIQUID COMPOSITIONS CAPABLE OF A619/00 (2006.01) FOAMING AND INCLUDING ACTIVE A63L/96 (2006.01) AGENTS, AND METHODS FOR MAKING OR A613 L/474 (2006.01) DEVELOPNG SAME A613 L/7048 (2006.01) A63L/92 (2006.01) (71) Applicant: MIKA Pharma GmbH A 6LX3/573 (2006.01) (52) U.S. Cl. (72) Inventor: Bernd G. Siegfried, Limburgerhof (DE) CPC ............... A61K 9/122 (2013.01); A61 K31/192 (2013.01); A61 K3I/I67 (2013.01); A61 K (21) Appl. No.: 14/633,929 31/573 (2013.01); A61K 31/196 (2013.01); A61K 31/4174 (2013.01); A61 K3I/7048 (22) Filed: Feb. 27, 2015 (2013.01); A61 K9/0014 (2013.01) Related U.S. Application Data (57) ABSTRACT (63) Continuation of application No. 12/838.737, filed on A liquid composition Suitable for topical use comprising is Jul. 19, 2010, now Pat. No. 9,005,626. provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active (30) Foreign Application Priority Data agent; wherein the liquid composition is capable of mechani cally foaming without an additional propellant; and wherein Jul. 24, 2009 (DE) ..................... 10-2009-034-603.1 upon mechanical foaming of 250 ml of the liquid composition results in a foam with a foam Volume of at least about 400 ml Publication Classification and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as (51) Int. Cl. determined using a SITA foam measurement. Also provided A6 IK 9/12 (2006.01) herein are methods of making disclosed compositions and A6 IK3I/67 (2006.01) methods of use. Patent Application Publication Jan. 28, 2016 Sheet 1 of 19 US 2016/0022579 A1 12OO 1 OOO Mam-m-m-m-MYu-a-wave-m---saw-aw-al-------------was 5 600 -- 1st measurement -- 2nd measurement -- 3rd measurement > w-r-marsaw-awaamhormoxamin-a----------Hermaxx-x-xx-x-x---winnu-mi 400 ----------------...------- ---------- ---.... t i S. 2001 - --- O - - ------- - s ----- - O.O. 5.0 10.0 15.0 2O.O 25.O 300 35.0 time (min) Figure 1 Patent Application Publication Jan. 28, 2016 Sheet 2 of 19 US 2016/0022579 A1 1000 - --------- -- 1st measurement -- 2nd measurement 800 -- 3rd measurement 6 O O 4 O O 200 ------------------------------------- -------- - ------- 3. cap.m.a.s. Im. -- - - - - --- OO 5.0 10.0 15.0 2O.O 25.0 30.O 35.0 time (min) Figure 2 Patent Application Publication Jan. 28, 2016 Sheet 3 of 19 US 2016/0022579 A1 1200 1000 800 6 OO --- 1st measurement | - 2nd measurement 4 O O -H--------------m-m-m-m-ul-------------- --m-mw------umu ---------. -- 3rd measurement 2 OO - --- -- -- f r 0.0 5.0 10.0 15.0 20.0 25.0 30.0 35.0 time (min) Figure 3 Patent Application Publication Jan. 28, 2016 Sheet 4 of 19 US 2016/0022579 A1 1200 - --- 1000 --- or ------ ----------------------- 800 S. ----------------------------------------------- - 600 --- ----- - 1st measurement 5 - 2nd measurement O 400 -------------------------- -- 3rd measurement s S 200 - ------ O -- ------- ... -- r --- O.O 5.O 1O.O 150 200 25 O 30.0 35.0 time (min) Figure 4 Patent Application Publication Jan. 28, 2016 Sheet 5 of 19 US 2016/0022579 A1 1200 1 OOO 800 6O O St n e a S. t re n e nt -- 2nd measurement ... 3rd measurement 4.O O 200 O.O 5.0 OO 150 2O.O 250 30.0 350 time (min) Figure 5 Patent Application Publication Jan. 28, 2016 Sheet 6 of 19 US 2016/0022579 A1 1200 -- 1 OOO -- --- ------ 800 || -- 1st measurement -- 2nd measurement S ... 3rd measurement a 600 - - T" ...------- vmm-mm-um-m-m-m-m-ul S E 9 S its S. 200 - - - -m-m-m------ -------------w 0 - s ----------.......... r -----...- O.O 5.O 10.0 15.O 2O.O 25.0 3OO 35.0 time (min) Figure 6 Patent Application Publication Jan. 28, 2016 Sheet 7 of 19 US 2016/0022579 A1 1200 WWWWSSM 1 OOO now--- ----------- 800 600 --------------------------- or " -- 1st measurement 5 -o-, 2nd measurement O 400 --- -- 3rd measurement s S. 200 v-M- M-----------------------------M. O ...un-----or- - error- r OO 5.O 10.0 150 200 250 30.0 350 time (min) Figure 7 Patent Application Publication Jan. 28, 2016 Sheet 8 of 19 US 2016/0022579 A1 1200 1000 - 800 : --------------------------------------------------------------------- S www.www.'xw8wimmwww.c. 600 - --------------------------------------- " " -- 1st reasurement -- 2nd measurement 9 -- 3rd measurement a 400 - - ------------------- s S. 200 | ------------------------------------ --- O -or- ---. " O.O 5.O 10.0 15.0 200 25.0 300 350 time (min) Figure 8 Patent Application Publication Jan. 28, 2016 Sheet 9 of 19 US 2016/0022579 A1 1200 - 1 OOO 800 --------...-a------e-r-sorror----useu------------, - 1st eaS feet -- 2nd measurement E | -- 3rd reasurement a 600 ------------------ - - - - ---- -------------------e.---------------------r-----------------m---------- E Eg E 400 --- ets S 2OO u...w....----------- m ---------------------------------- O 0.0 5.O 10.0 15.0 2O.O 250 3O.O 350 time (min) Figure 9 Patent Application Publication Jan. 28, 2016 Sheet 10 of 19 US 2016/0022579 A1 g 800 – ---- ... -- 1st measurement o -- 2nd measurement 2E 600 | -- 3rdric reasurement g ------------ 400 - - ----------- S. 200 -------- M O ar ------or-cro-or-n- 0.0 5.0 10.0 15.0 20.0 25.0 30.0 350 time (min) Figure 10 Patent Application Publication Jan. 28, 2016 Sheet 11 of 19 US 2016/0022579 A1 1200 ---. ------------ ------- 1000 ------ MM ... ----- 800 E 600 - ----------------- um-----m------------------ :rum-ric-owner-winner-writtan...a...s.l...a...covar. --- 1st measurement s -a- 2nd measurement g -- 3rd measurement 400 +- m-m-m- --- s S. 200 O - } : ------------ - - - 0.0 5.0 10.0 15.0 20.0 25.0 30.0 35.0 time (min) Figure 11 Patent Application Publication Jan. 28, 2016 Sheet 12 of 19 US 2016/0022579 A1 1200 . 1000 —- -- 1st measurement | -- 2nd measurement 800 --------- or--or | ---- 3rdouMW&W-WWW-WWWW-8wm-W-WWWrwoxwmwmw-vom measurement E 600 m'W SSM MMM v. M' S st EEs is ESE=E. S. g E 400 - - es S 200 O ~rom s - : O.O 5.0 1.O.O 15.O 200 25.O 3OO 35.O time (min) Figure 12 Patent Application Publication Jan. 28, 2016 Sheet 13 of 19 US 2016/0022579 A1 1200 ---—- - - -—-----------------------------------------------—--- 1OOO 600 ir-r- . 1st measurement - 2nd measurement 400 -- 3rd measurement 2OO car---...-------------- ---— — — -r-sna. 50 1 OO 150 2O.O 25.O 3OO 35.O time (min) Figure 13 Patent Application Publication Jan. 28, 2016 Sheet 14 of 19 US 2016/0022579 A1 1200 - --------- ------- - - 1000 - - 800 -------- ------- - - - - 1st measurement --a | -- 2nd measurement -- 3rd measurement Sc. 600 -------- ... --- c) E 2 9 400 (vs. ---------------- 200 - - - - ------ m - - - - - - s-- - - - - --- ...W---- -- O - ------- ----- -r T -- run-- : 0.0 50 10.0 150 200 25.0 30.0 35.0 time (min) Figure 14 Patent Application Publication Jan. 28, 2016 Sheet 15 of 19 US 2016/0022579 A1 12OO -------- 1OOO l ---- res-Ferra ara-a-a====Es==ss-seas-s-s-s-s-s-s-s------ 8OO --- mmM ----------- M - Mammam - M. 5 | -----------------------M.--...--------------armw 600 mm M. maa SMWM -- 1st measurement ----, 2nd measurer ent E 400 - -- 3rd measurement t S 200 - O | : O.O 5.O 1O.O 15.O 2O.O 25.O 3OO 350 time (min) Figure 15 Patent Application Publication Jan. 28, 2016 Sheet 16 of 19 US 2016/0022579 A1 1200 1OOO 800 - 2 E 600 - - wo-wrim-X-rw-w-X-rm-------xx-cc-awww.twin-ex-xx-xx-x-------.- - - 1st measurement 5 | -- 2nd measurement aO 400 - ----. 3rd measurement s S 2OO mmM O - I p-r- OO 5.O 1O.O 15.O 2O.O 250 3O.O 35.O time (min) Figure 16 Patent Application Publication Jan. 28, 2016 Sheet 17 of 19 US 2016/0022579 A1 1200 1000 - -------------------------------m-m-m-m-m-m- 800 1. 600 ------- - 1st measurement 5 -- 2nd reasurement g -- 3rd measurement E 400 - --- -- 4th measurement (ts S. -- 5th measurement 200 wuwassetesveterosoretirestro-o-o-o-wross-orie,--- 0 - for- I 0.0 5.0 10.0 15.O 2O.O 250 3O.O 35.0 time (min) Figure 17 Patent Application Publication Jan. 28, 2016 Sheet 18 of 19 US 2016/0022579 A1 -- 1st measurement -as-, 2nd measurement -- 3rd measurement 4O O - " ------or-o- 2OO -------...ru------ 0.0 5.0 10.0 150 20.0 25.0 30.0 35.0 time (min) Figure 18 Patent Application Publication Jan. 28, 2016 Sheet 19 of 19 US 2016/0022579 A1 1200 Tri- ----- - - - - - - - - - - - - - - - ----------------------------- 1000 -------------- - - - - - - - - - - ------------ wom 800 5 film-m-m-m-m-on-count cy 600 - -e- 1st measurement 5 -a- 2nd measurement O 400 - 3rd measurement es S. 200 - - O I --------------.... ...--—----------- OO 5.O 10.0 15.0 2O.O 250 3OO 35.0 time (min) Figure 19 US 2016/0022579 A1 Jan. 28, 2016 LIQUID COMPOSITIONS CAPABLE OF maceutically active liquid and one then attempts to foam it by FOAMING AND INCLUDING ACTIVE varying the mechanical foaming technique, in particular, by AGENTS, AND METHODS FOR MAKING OR varying the air pressure, the geometry and configuration of DEVELOPING SAME the foam head and the valve of a particular foam applicator. However, such a development process for foamable, origi RELATED APPLICATION nally liquid, pharmaceutical compositions is very time inten sive and may suffer from a drawback such that a foam differ 0001. This application is a continuation of U.S. Ser. No. ing in composition and essentially inhomogeneous can result 12/838,737 filed Jul. 19, 2010, which claims priority to Ger from varying the configuration of the aforementioned param man patent application DE10-2009-034-603.1, filed Jul.
Load more

Recommended publications
  • Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report
    Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
    [Show full text]
  • United States Patent (19) 11 Patent Number: 5,253,711 Mondshine (45) Date of Patent: Oct
    USOO525371 1A United States Patent (19) 11 Patent Number: 5,253,711 Mondshine (45) Date of Patent: Oct. 19, 1993 54) PROCESS FOR DECOMPOSING 2,268,215 12/1941 Kerr ...................................... 127/33 POLYSACCHARDES IN ALKALINE 3,167,510 /1965 Alter ..... sa as A8 a X8 a P. 252/8.551 3,655,644 4/1972 Durand ........................... 106/21 X AQUEOUS SYSTEMS 3,935,187 1/1976 Speakman ........................... 536/102 75 Inventor: Thomas C. Mondshine, Houston, 4,202,795 5/1980 Burnham et al. ............... 166/308 X Tex. 4,552,668 11/1985 Brown et al. ................... 166/300X Lachenal et al. ..................... 162/25 Assignee: Texas United Chemical Corp., 4,787,959 11/1988 (73) Primary Examiner-George A. Suchfield Houston, Tex. Attorney, Agent, or Firm-Roy F. House 21 Appl. No.: 844,167 57 ABSTRACT 22 Filed: Mar. 2, 1992 Alkaline earth metal or transition metal peroxides are (51) int. Cli.............................................. E21B 43/26 used as a delayed breaker in alkaline aqueous fluids 52) U.S. C. .................................... 166/300; 166/308; containing a water soluble hydrophilic polysaccharide 252/8.551; 252/326 polymer hydrated therein. The peroxide is activated by (58) Field of Search ............................... 166/300, 308; increasing the temperature of the fluid. The invention is 252/8.551, 326,358; 536/41, 80, 88 particularly useful for the delayed break of hydraulic 56) References Cited fracturing fluids containing hydroxypropyl guar poly c. U.S. PATENT DOCUMENTS i,953,398 4/1934 Eskew ................................... 536/41 10 Claims, No Drawings 5,253,711 1. 2 G. W. Hawkins, and H. D. Brannon, Feb.
    [Show full text]
  • Chemical List
    1 EXHIBIT 1 2 CHEMICAL CLASSIFICATION LIST 3 4 1. Pyrophoric Chemicals 5 1.1. Aluminum alkyls: R3Al, R2AlCl, RAlCl2 6 Examples: Et3Al, Et2AlCl, EtAlCl2, Me3Al, Diethylethoxyaluminium 7 1.2. Grignard Reagents: RMgX (R=alkyl, aryl, vinyl X=halogen) 8 1.3. Lithium Reagents: RLi (R = alkyls, aryls, vinyls) 9 Examples: Butyllithium, Isobutyllithium, sec-Butyllithium, tert-Butyllithium, 10 Ethyllithium, Isopropyllithium, Methyllithium, (Trimethylsilyl)methyllithium, 11 Phenyllithium, 2-Thienyllithium, Vinyllithium, Lithium acetylide ethylenediamine 12 complex, Lithium (trimethylsilyl)acetylide, Lithium phenylacetylide 13 1.4. Zinc Alkyl Reagents: RZnX, R2Zn 14 Examples: Et2Zn 15 1.5. Metal carbonyls: Lithium carbonyl, Nickel tetracarbonyl, Dicobalt octacarbonyl 16 1.6. Metal powders (finely divided): Bismuth, Calcium, Cobalt, Hafnium, Iron, 17 Magnesium, Titanium, Uranium, Zinc, Zirconium 18 1.7. Low Valent Metals: Titanium dichloride 19 1.8. Metal hydrides: Potassium Hydride, Sodium hydride, Lithium Aluminum Hydride, 20 Diethylaluminium hydride, Diisobutylaluminum hydride 21 1.9. Nonmetal hydrides: Arsine, Boranes, Diethylarsine, diethylphosphine, Germane, 22 Phosphine, phenylphosphine, Silane, Methanetellurol (CH3TeH) 23 1.10. Non-metal alkyls: R3B, R3P, R3As; Tributylphosphine, Dichloro(methyl)silane 24 1.11. Used hydrogenation catalysts: Raney nickel, Palladium, Platinum 25 1.12. Activated Copper fuel cell catalysts, e.g. Cu/ZnO/Al2O3 26 1.13. Finely Divided Sulfides: Iron Sulfides (FeS, FeS2, Fe3S4), and Potassium Sulfide 27 (K2S) 28 REFERRAL
    [Show full text]
  • Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set
    MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,645,535 B2 Zyck Et Al
    USOO6645535B2 (12) United States Patent (10) Patent No.: US 6,645,535 B2 Zyck et al. (45) Date of Patent: *Nov. 11, 2003 (54) METHOD OF MAKING COATED CHEWING FR 2 635 441 2/1990 GUMPRODUCTS CONTAINING WARIOUS FR 2 706 771 6/1993 ANTACIDS GB O 934,596 8/1963 GB O 963 518 7/1964 GB 1489,832 10/1977 (75) Inventors: Daniel J. Zyck, North Riverside, IL GB 2181646 A 4/1987 (US); Michael J. Greenberg, IT O2173487 7/1997 Northbrook, IL (US); David G. IT O1293655 3/1999 Barkalow, Deerfield, IL (US); Scott W. JP 1991-112450 5/1991 Marske, LaGrange, IL (US); Philip G. JP 1991-251533 11/1991 Schnell, Downers Grove, IL (US); JP 1994-303911 11/1994 Philip Mazzone, Griffith, IN (US) JP 1996-19370 1/1996 JP 86/242561 10/1996 (73) Assignee: WM. Wrigley Jr. Company, Chicago, KR 94-2868 4/1994 WO WO 84/02271 6/1984 IL (US) WO WO 90/12511 11/1990 WO WO 90/12583 11/1990 (*) Notice: Subject to any disclaimer, the term of this WO WO 92/06680 4/1992 patent is extended or adjusted under 35 WO WO95/OOO38 1/1995 U.S.C. 154(b) by 53 days. WO WO95/OOO39 1/1995 WO WO95/10290 4/1995 This patent is Subject to a terminal dis WO WO 96/OOO70 1/1996 claimer. WO WO 96/03975 2/1996 WO WO 97/21424 6/1997 WO WO 97/24036 6/1997 (21) Appl. No.: 09/747,323 WO WO 98/231.65 6/1998 (22) Filed: Dec.
    [Show full text]
  • EUROPEAN PHARMACOPOEIA 10.0 Index 1. General Notices
    EUROPEAN PHARMACOPOEIA 10.0 Index 1. General notices......................................................................... 3 2.2.66. Detection and measurement of radioactivity........... 119 2.1. Apparatus ............................................................................. 15 2.2.7. Optical rotation................................................................ 26 2.1.1. Droppers ........................................................................... 15 2.2.8. Viscosity ............................................................................ 27 2.1.2. Comparative table of porosity of sintered-glass filters.. 15 2.2.9. Capillary viscometer method ......................................... 27 2.1.3. Ultraviolet ray lamps for analytical purposes............... 15 2.3. Identification...................................................................... 129 2.1.4. Sieves ................................................................................. 16 2.3.1. Identification reactions of ions and functional 2.1.5. Tubes for comparative tests ............................................ 17 groups ...................................................................................... 129 2.1.6. Gas detector tubes............................................................ 17 2.3.2. Identification of fatty oils by thin-layer 2.2. Physical and physico-chemical methods.......................... 21 chromatography...................................................................... 132 2.2.1. Clarity and degree of opalescence of
    [Show full text]
  • Chemical Names and CAS Numbers Final
    Chemical Abstract Chemical Formula Chemical Name Service (CAS) Number C3H8O 1‐propanol C4H7BrO2 2‐bromobutyric acid 80‐58‐0 GeH3COOH 2‐germaacetic acid C4H10 2‐methylpropane 75‐28‐5 C3H8O 2‐propanol 67‐63‐0 C6H10O3 4‐acetylbutyric acid 448671 C4H7BrO2 4‐bromobutyric acid 2623‐87‐2 CH3CHO acetaldehyde CH3CONH2 acetamide C8H9NO2 acetaminophen 103‐90‐2 − C2H3O2 acetate ion − CH3COO acetate ion C2H4O2 acetic acid 64‐19‐7 CH3COOH acetic acid (CH3)2CO acetone CH3COCl acetyl chloride C2H2 acetylene 74‐86‐2 HCCH acetylene C9H8O4 acetylsalicylic acid 50‐78‐2 H2C(CH)CN acrylonitrile C3H7NO2 Ala C3H7NO2 alanine 56‐41‐7 NaAlSi3O3 albite AlSb aluminium antimonide 25152‐52‐7 AlAs aluminium arsenide 22831‐42‐1 AlBO2 aluminium borate 61279‐70‐7 AlBO aluminium boron oxide 12041‐48‐4 AlBr3 aluminium bromide 7727‐15‐3 AlBr3•6H2O aluminium bromide hexahydrate 2149397 AlCl4Cs aluminium caesium tetrachloride 17992‐03‐9 AlCl3 aluminium chloride (anhydrous) 7446‐70‐0 AlCl3•6H2O aluminium chloride hexahydrate 7784‐13‐6 AlClO aluminium chloride oxide 13596‐11‐7 AlB2 aluminium diboride 12041‐50‐8 AlF2 aluminium difluoride 13569‐23‐8 AlF2O aluminium difluoride oxide 38344‐66‐0 AlB12 aluminium dodecaboride 12041‐54‐2 Al2F6 aluminium fluoride 17949‐86‐9 AlF3 aluminium fluoride 7784‐18‐1 Al(CHO2)3 aluminium formate 7360‐53‐4 1 of 75 Chemical Abstract Chemical Formula Chemical Name Service (CAS) Number Al(OH)3 aluminium hydroxide 21645‐51‐2 Al2I6 aluminium iodide 18898‐35‐6 AlI3 aluminium iodide 7784‐23‐8 AlBr aluminium monobromide 22359‐97‐3 AlCl aluminium monochloride
    [Show full text]
  • Topical Pharmaceutical Compositions
    Europâisches Patentamt 0 085 579 ® ê European Patent Office @ Publication number: B1 Office européen des brevets ® EUROPEAN PATENT SPECIFICATION @ Date of publication of patent spécification: 06.05.87 ® Intel.4: A 61 K 45/06, A 61 K 31/195, A 61 K 31/20, A 61 K 31/375, (H) Application number: 83300531.7 A 61 K 31/585, A 61 K 31/19, © Date offiling: 02.02.83 A 61 K 31/61, A 61 K 31/355, A 61 K 31/715, A 61 K 33/30, A 61 K 35/78 (54) Topical pharmaceutical compositions. (§) Priority: 03.02.82 US 345204 (73) Proprietor: EFAMOL LIMITED 12th Floor Moor House London Wall London EC2Y 5HE (GB) (§) Date of publication of application: 10.08.83 Bulletin 83/32 ® Inventor: Horrobin, David Frederick P.O.Box 10 Nuns Island (§) Publication of the grant of the patent: Montréal H3E 1 J8 (CA) 06.05.87 Bulletin 87/19 Inventor: Lieb, Julian 41 Village Lane Bethany Connecticut 06525 (US) (S) Designated Contracting States: AT BE CH DE FR GB IT Ll LU NL SE (74) Représentative: Cockbain, Julian Roderick Michaelson et al - (§) Références cited: Frank B. Dehn & Co. European Patent Attorneys EP-A-0 068854 Impérial House 15-19, Kingsway US-A-3 639 625 London WC2B 6UZ (GB) US-A-4328243 CÛ O) in LO oo o o Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted.
    [Show full text]
  • Alphabetical Listing of ATC Drugs & Codes
    Alphabetical Listing of ATC drugs & codes. Introduction This file is an alphabetical listing of ATC codes as supplied to us in November 1999. It is supplied free as a service to those who care about good medicine use by mSupply support. To get an overview of the ATC system, use the “ATC categories.pdf” document also alvailable from www.msupply.org.nz Thanks to the WHO collaborating centre for Drug Statistics & Methodology, Norway, for supplying the raw data. I have intentionally supplied these files as PDFs so that they are not quite so easily manipulated and redistributed. I am told there is no copyright on the files, but it still seems polite to ask before using other people’s work, so please contact <[email protected]> for permission before asking us for text files. mSupply support also distributes mSupply software for inventory control, which has an inbuilt system for reporting on medicine usage using the ATC system You can download a full working version from www.msupply.org.nz Craig Drown, mSupply Support <[email protected]> April 2000 A (2-benzhydryloxyethyl)diethyl-methylammonium iodide A03AB16 0.3 g O 2-(4-chlorphenoxy)-ethanol D01AE06 4-dimethylaminophenol V03AB27 Abciximab B01AC13 25 mg P Absorbable gelatin sponge B02BC01 Acadesine C01EB13 Acamprosate V03AA03 2 g O Acarbose A10BF01 0.3 g O Acebutolol C07AB04 0.4 g O,P Acebutolol and thiazides C07BB04 Aceclidine S01EB08 Aceclidine, combinations S01EB58 Aceclofenac M01AB16 0.2 g O Acefylline piperazine R03DA09 Acemetacin M01AB11 Acenocoumarol B01AA07 5 mg O Acepromazine N05AA04
    [Show full text]
  • Facile Fabrication of Oxygen-Releasing Tannylated Calcium Peroxide Nanoparticles
    materials Article Facile Fabrication of Oxygen-Releasing Tannylated Calcium Peroxide Nanoparticles Ji Sun Park, Yeong Jun Song, Yong Geun Lim and Kyeongsoon Park * Department of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi 17546, Korea; [email protected] (J.S.P.); [email protected] (Y.J.S.); [email protected] (Y.G.L.) * Correspondence: [email protected]; Tel.: +82-31-670-3357 Received: 16 July 2020; Accepted: 31 August 2020; Published: 1 September 2020 Abstract: This study reports a new approach for the facile fabrication of calcium peroxide (CaO2) nanoparticles using tannic acid (TA) as the coordinate bridge between calcium ions. Tannylated-CaO2 (TA/CaO2) nanoparticles were prepared by reacting calcium chloride (CaCl2) with hydrogen peroxide (H2O2) in ethanol containing ammonia and different amounts of TA (10, 25, and 50 mg). The prepared TA/CaO2 aggregates consisted of nanoparticles 25–31 nm in size. The nanoparticles prepared using 10 mg of TA in the precursor solution exhibited the highest efficiency for oxygen generation. Moreover, the oxygen generation from TA (10 mg)/CaO2 nanoparticles was higher in an acidic environment. Keywords: calcium peroxide; tannic acid; oxygen generation 1. Introduction The delivery of sufficient amounts of oxygen to transplanted cells and 3D-engineered tissues remains among the main challenges in the field of cellular engineering [1]. Oxygen deficiency in these cells results in poor extracellular matrix deposition, cell death, and tissue necrosis [2]. Moreover, hypoxic tumor cells in solid tumor tissues are more resistant to radiation and chemotherapy [3,4]. Therefore, the prevention of hypoxia in 3D scaffolds during transplantation and in solid tumors during cancer therapy is essential for enhancing therapeutic effects.
    [Show full text]
  • 3.2.2 Table B: List of Dangerous Goods in Alphabetical Order the Following
    Copyright © United Nations, 2008 3.2.2 Table B: List of dangerous goods in alphabetical order The following Table B is an alphabetical list of the substances and articles which are listed in the UN numerical order in Table A of 3.2.1. It does not form an integral part of ADN. It has been prepared, with all necessary care by the Secretariat of the United Nations Economic Commission for Europe, in order to facilitate the consultation of Annexes A and B, but it cannot be relied upon as a substitute for the careful study and observance of the actual provisions of those annexed Regulations which, in case of conflict, are deemed to be authoritative. NOTE 1: For the purpose of determining the alphabetical order the following information has been ignored, even when it forms part of the proper shipping name: numbers; Greek letters; the abbreviations "sec" and "tert"; and the letters "N" (nitrogen), "n" (normal), "o" (ortho) "m" (meta), "p" (para) and "N.O.S." (not otherwise specified). NOTE 2: The name of a substance or article in block capital letters indicates a proper shipping name (see 3.1.2). NOTE 3: The name of a substance or article in block capital letters followed by the word "see" indicates an alternative proper shipping name or part of a proper shipping name (except for PCBs) (see 3.1.2.1). NOTE 4: An entry in lower case letters followed by the word "see" indicates that the entry is not a proper shipping name; it is a synonym. NOTE 5: Where an entry is partly in block capital letters and partly in lower case letters, the latter part is considered not to be part of the proper shipping name (see 3.1.2.1).
    [Show full text]
  • ACCGE 2015 Abstracts Ebook
    Table of Contents Introduction/Plenary Correlated Electron Crystals 1 Detector Materials: Scintillators and Semiconductors (ACCGE) 1 Fundamentals of Crystal Growth (ACCGE) 1 III-V Nitride, SiC, and Other Wide Bandgap Materials (Joint ACCGE/OMVPE) 1 Second Symposium on 2D Electronic Materials (Joint ACCGE/OMVPE) 1 Correlated Electron Crystals 2 Detector Materials: Scintillators and Semiconductors (ACCGE) 2 Fundamentals of Crystal Growth (ACCGE) 2 III-V Nitride, SiC, and Other Wide Bandgap Materials (Joint ACCGE/OMVPE) 2 Second Symposium on 2D Electronic Materials (Joint ACCGE/OMVPE) 2 Detector Materials: Scintillators and Semiconductors (ACCGE) 3 Fundamentals of Crystal Growth (ACCGE) 3 III-V Nitride, SiC, and Other Wide Bandgap Materials (Joint ACCGE/OMVPE) 3 Second Symposium on 2D Electronic Materials (Joint ACCGE/OMVPE) 3 Poster Session 1 III-Vs on Silicon (Joint ACCGE/OMVPE) 1 Young Author and AACG Awards Detector Materials: Scintillators and Semiconductors (ACCGE) 4 Fundamentals of Crystal Growth (ACCGE) 4 III-Vs on Silicon (Joint ACCGE/OMVPE) 2 Second Symposium on 2D Electronic Materials (Joint ACCGE/OMVPE) 4 III-V Nitride, SiC, and Other Wide Bandgap Materials (Joint ACCGE/OMVPE) 4 Nonlinear Optical and Laser Host Materials (ACCGE) 1 Thin Film Growth, Epitaxy, and Superlattices (Joint ACCGE/OMVPE) 1 Second Symposium on 2D Electronic Materials (Joint ACCGE/OMVPE) 5 III-V Nitride, SiC, and Other Wide Bandgap Materials (Joint ACCGE/OMVPE) 5 Materials for Photovoltaics and Energy Technology (Joint ACCGE/OMVPE) 1 Nonlinear Optical and
    [Show full text]