Clinical trial protocol

Title

Phase III Randomized Study of Standard Chemoradiotherapy With Versus Without High-Dose Methotrexate in Pediatric Patients With Newly Diagnosed, Malignant High- Grade Glioma or Diffuse Intrinsic Pontine Glioma

Inclusion Criteria

Ages Eligible for Study: 3 Years - 18 Years, Genders Eligible for Study: Both

DISEASE CHARACTERISTICS:

• Newly diagnosed tumors of the brain or spinal cord, meeting one of the following criteria: • Histologically* confirmed diagnosis of 1 of the following high-grade gliomas: • Glioblastoma (WHOº IV) • Anaplastic astrocytoma (WHOº III) • Gliosarcoma (WHOº III or IV) • Anaplastic oligo-astrocytoma NOTE: *Histological requirement may be waived for other types of brainstem glioma • Radiologically proven diffuse intrinsic pontine glioma • Second malignancy or disseminate metastases or multifocal tumors are allowed if the field of irradiation is not too large • No diffuse metastases making craniospinal irradiation necessary

PATIENT CHARACTERISTICS: • No cardiorespiratory insufficiency requiring medical respiration • No low blood pressure requiring systemic catecholamines • No severe neurological damage (e.g., coma) • No tetraplegia without possibility to communicate • No other poor clinical condition • Not pregnant • Fertile patients must use effective contraception • No hypersensitivity to methotrexate, cisplatin, vincristine, lomustine, or ifosfamide • No other malignancy preceding radiotherapy that does not allow further radiation

PRIOR CONCURRENT THERAPY: • No prior chemotherapy for brain tumor • The following prior therapies are allowed: • Mistletoe • H15 (extract of Boswellia serrata) • Homeopathy therapy with dilution > 4D • Alternative medicine without proven efficacy • No prior radiotherapy for brain tumor • No concurrent alcohol or tobacco consumption • No concurrent participation in another study

Expected number of patients 150

Trial phase Phase III

Orphanet Database. Clinical trial 2006 - 1 http://www.orpha.net/data/eth/DE/ID39846Eng.pdf

Drug Drug: cisplatin Drug: etoposide Drug: ifosfamide Drug: lomustine Drug: methotrexate Drug: prednisone Drug: vincristine

International multicenter study

Purpose

OBJECTIVES

Primary

• Determine if the addition of high-dose methotrexate prior to standard treatment improves survival of patients with malignant high-grade glioma or diffuse intrinsic pontine glioma as compared to standard treatment only.

Secondary • Determine if the addition of high-dose methotrexate, as compared to standard treatment only, improves the tumor response of these patients. • Determine if high-dose methotrexate, compared to standard treatment only, improves the progression-free or event-free survival of these patients. • Determine if high-dose methotrexate, as compared to standard treatment only, improves the health status (quality of life) of these patients. • Determine if consolidation therapy improves the overall, progression-free, or event-free survival rates as compared to the historical control group.

OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to tumor location includes pons (yes vs no) and complete or nearly complete resection (yes vs no).

• Surgery: All patients are encouraged to undergo radical resection of the tumor to reduce intracranial pressure, remove as much tumor tissue as possible, and obtain tumor tissue for histological diagnosis. Within 14 days after surgery, patients proceed to induction chemotherapy. • Patients are randomized to 1 of 2 treatment arms. • High-dose methotrexate with leucovorin calcium: Patients receive high-dose methotrexate IV over 24 hours on days 1 and 15 and leucovorin calcium IV every 6 hours on days 2-3 an 16-17. Patients proceed to chemoradiotherapy 4 weeks later. • Chemoradiotherapy (course 1): Patients undergo external beam radiotherapy once daily, 5 days a week, for approximately 6 weeks. Beginning on the first day of radiotherapy, patients receive cisplatin IV over 1 hour on days 1-5, etoposide IV over 2 hours on days 1-3, and vincristine IV on days 5, 12, 19, 26, and 33. Patients proceed to course 2 of chemoradiotherapy 7 days prior to completion of radiotherapy. • Chemoradiotherapy (course 2): Patients receive ifosfamide IV over 1 hour and cisplatin IV over 1 hour on days 1-5, etoposide IV over 2 hours on days 1-3, and vincristine IV on day 5. Patients proceed to consolidation chemotherapy 4 weeks later. • Arm II: Patients receive chemoradiotherapy courses 1 and 2 as in arm I and proceed to consolidation chemotherapy 4 weeks later. • Consolidation chemotherapy: Patients receive vincristine IV on days 1, 8, and 15, oral lomustine once on day 2, and oral prednisone once daily on days 1-17. Treatment repeats every 6 weeks for up to 8 courses.

Quality of life is assessed 1 week after surgery, after completion of chemoradiotherapy, at 1, 4, and 13 months after completion of consolidation chemotherapy, and then annually for 3 years. After completion of study treatment, patients are followed periodically for 3 years

Orphanet Database. Clinical trial 2006 - 2 http://www.orpha.net/data/eth/DE/ID39846Eng.pdf