DOCSLIB.ORG

WSC 14-15 Conf 7 Layout

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
WSC 14-15 Conf 7 Layout Joint Pathology Center Veterinary Pathology Services WEDNESDAY SLIDE CONFERENCE 2014-2015 Conference 7 22 October 2014 CASE I: B13-962 (JPC 4049563). performed at that time. The dog presented again in July 2013 with continued hematuria. On Signalment: 10-year-old spayed female Welsh ultrasound, the left renal cortex had a 2.2 cm, corgi dog, Canis familiaris. round, heterogeneous mass with multiple, internal, anechoic regions. History: The dog presented in 2011 for a 6-week history of hematuria. Urine culture was negative Gross Pathology: The renal cortex was and no signs of uroliths were seen on radiographs. extensively disrupted by coalescing, dark red, Ultrasound revealed two, 1.7 mm, mineralized blood-filled nodules ranging from 0.7 x 0.5 x 0.2 foci in the left renal pelvis, but the kidneys were cm to 2.5 x 2 x 2 cm. normal in shape and size. No further workup was Histopathologic Description: Kidney: The renal interstitium is markedly expanded by many, severely dilated, blood-filled vascular spaces lined by mature endothelial cells surrounded by abundant fibrous tissue. Some vascular spaces contain thrombi with fibrin arranged as lines of Zahn separated by red and white blood cells that are occasionally attached to the vascular wall by fibrous tissue. The intervening and adjacent renal parenchyma is markedly atrophic with replacement of many nephrons by fibrosis, many lymphocytes and plasma cells, and variable 1-1. Kidney, Welsh corgi: The cortex is expanded by large, ectatic, thin-walled vessels which efface renal parenchyma. (HE 6.3X) hemorrhage. Remaining tubules 1 WSC 2014-2015 1-2. Kidney, Welsh corgi: Vessels are thin-walled and separated by a 1-3. Kidney, Welsh corgi: Larger vessels are partially occluded with moderate fibrous stroma. (HE 144X) fibrinous thrombi which contain lines of Zahn. (HE 35X) and glomeruli in these areas are often atrophic or telangiectasia in Pembroke Welsh corgis as sclerotic, respectively. Some tubules contain described in the literature characteristically arises proteinaceous fluid. The renal pelvis contains bilaterally with frequent occurrences in other degenerating erythrocytes and brown, granular organs. The clinical history in this case suggests pigment. The more distant renal parenchyma is the lesion is isolated to one kidney; however, the unremarkable apart from congestion. lesion lacks the well-circumscribed appearance of a hemangioma. The signalment and clinical signs Contributor’s Morphologic Diagnosis: Kidney: do not correlate well with a hamartoma, which Renal telangiectasia. implies a congenital proliferation. The diagnosis of vascular malformation reflects these Contributor’s Comment: Renal telangiectasia is inconsistencies and participants’ inability to arrive a rare, non-neoplastic proliferation of blood at a consensus. vessels.3 It has been described in the Welsh corgi as a familial disease, and similar lesions have The pattern of presentation in corgis interestingly been described in cattle, dogs, cats, mink and resembles a familial condition in people known as ferrets.2 Affected corgis typically present for hereditary hemorrhagic telangiectasia (HHT). hematuria and may have bilateral lesions or Also known as Osler-Weber-Rendu disease, this additional lesions in other tissues, such as the autosomal dominant disorder occurs at a rate of 1 liver, duodenum, brain, vertebrae, subcutaneous in 5,000 people and manifests as telangiectasia of tissue, and spleen.3,4 In this case, no contralateral the oral mucosa and arteriovenous malformations or extra-renal lesions were identified by in the lungs, liver and less often brain. Three abdominal ultrasound or at surgery. The primary mutations have been identified in HHT, all with clinical differential in this case was renal protein products influencing the TGF-β hemangiosarcoma. Renal telangiectasia is superfamily.5 differentiated histologically from hemangiosarcoma by the fact that the vascular TGF-β is a growth inhibitor of most epithelial spaces are lined by a bland, mature endothelium cells but a potent stimulator of fibroblasts. Its without mitotic activity or cellular atypia.4 binding to cell-surface receptors leads to phosphorylation of SMAD transcription factors, JPC Morphologic Diagnosis: Kidney: Vascular specifically Co-SMAD & R-SMAD. When malformation with multifocal thrombosis. phosphorylated, these factors overcome SMAD-7 inhibition, thereby promoting transcription and Conference Comment: Conference participants activation of fibroblasts. Additionally and likely discussed three optional diagnoses for this case: pertaining to these vascular lesions, TGF-β is telangiectasia, hemangioma or vascular strongly implicated in the stabilization of nascent hamartoma. The familial lesion of renal blood vessels, following their sprouting and 2 WSC 2014-2015 migration through the finely orchestrated events coordinated by VEGF and the Notch pathway.1 This inheritable condition has serious consequences in people due to their predisposition for hemorrhages and thrombosis. The understanding of disease pathogenesis has also shed new light on the specific molecular interactions of angiogenesis, one of the hallmarks of cancer. The authors speculated on the value of Pembroke Welsh corgis serving as an animal model for vascular malformations over 30 years ago.3 While knockout mice have been developed which reproduce these lesions, this naturally occurring canine model may offer further valuable insight in piecing together the complex interactions of angiogenesis and its role in vascular malformations and neoplasia. Contributing Institution: Tufts Cummings School of Veterinary Medicine Department of Biomedical Sciences 200 Westboro Road North Grafton, MA 01536 http://vet.tufts.edu/dbs/ References: 1. Kumar V, Abbas AK, Fausto N, Aster JC. Tissue renewal, regeneration and repair. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, PA: Elsevier Saunders; 20010:89, 100-101. 2. Maxie MG, Newman SJ. Urinary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. 5th ed. Vol 2. Philadelphia, PA: Elsevier Saunders; 2007:495. 3. Meuten DJ. Tumors of the urinary system. In: Tumors in Domestic Animals. 4th ed. Ames, IA; Iowa State Press; 2002:524. 4. Moore FM, Thornton GW. Telangiectasia of Pembroke Welsh corgi dogs. Vet Pathol. 1983;20(2):203-8. 5. Shovlin CL. Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Reviews. 2010;24:203-219. 3 WSC 2014-2015 CASE II: 1259066 (JPC 4048671). hyperglobulinemia and moderately elevated ALT and AST. Signalment: 6-year-old spayed female Vizsla dog, Canis familiaris. Therapeutic interventions included clindamycin, fluconazole, cytoarabine, and prednisolone at an History: The patient had a 6-month history of immunosuppressive dose. The tentative clinical minor incontinence followed by a 3-month history diagnosis was meningoencephalitis of unknown of recurrent UTI’s, which were treated by the origin with concern about fungal disease or GME. referring veterinarian with estradiol cypionate and The dog was discharged from the hospital 5 days antibiotics respectively (consecutive ampicillin, after admission. During the following 2 weeks, chloramphenicol, cephalexin, and metronidazole). the patient re-presented for weight loss, muscle The patient had a 1-month history of ataxia and wasting, and progressive ataxia leading to progressively more frequent vomiting. She tetraparesis. The patient arrested shortly after presented to Urgent Care Service on 7/27 for presentation to urgent care in lateral recumbency worsening neurologic signs, anorexia, lethargy, and respiratory distress. and PU/PD. Radiographs obtained were inconclusive. The patient was referred for Gross Pathology: At necropsy, the dog was in neurology consult, recommended MRI, and very poor body condition (BCS = 2/9). Her remained for inpatient diagnostic testing and mucous membranes and non-haired pinnae were treatment for 5 days. markedly pale and eyes were recessed. In the kidneys, there were numerous miliary, pale tan, 1 During diagnostic workup, there was mild C5-C6 to 2 mm diameter foci on the capsular surface that disc protrusion noted on cervical myelogram. On often extended in multifocal rays into the post-contrast T1 weighted MR images, there was medullas. Similar minute nodules and streaks meningeal enhancement spinal cord through C1 were throughout the myocardium. In the brain and and ventral to the brain stem and pons, as well as spinal cord, there was moderate purulent subdural faint contrast enhancement in the cerebellum. On exudate (meningoencephalitis). The liver was cerebellomedullary cistern cerebrospinal fluid diffusely friable, and moderately enlarged with aspirate cytology there was a severe mixed rounded edges. The small and large intestines pleocytosis. Neospora and Toxoplasma PCR and were segmentally reddened and thickened with serology, Cryptococcus latex agglutination, and multifocal irregular mucosal ulcerations. Multiple bacterial cultures were all negative. Thoracic lymph nodes are moderately expanded by radiographs were unremarkable. Serum irregular firm to caseated foci. The adrenal biochemistry findings were mild cortices were mildly bilaterally thin (atrophy, consistent with steroid administration). 2-1. Kidney, dog: Linear hypercellular foci replace cortical and 2-2. Kidney, dog: The interstitium is infiltrated and tubules are replaced medullary parenchyma. (HE 7X) by large numbers of macrophages,
Load more

Recommended publications
  • Paraneoplastic Syndrome Presenting As Giant Porokeratosis in a Patient with Nasopharyngeal Cancer
    Paraneoplastic Syndrome Presenting As Giant Porokeratosis in A Patient with Nasopharyngeal Cancer Fitri Azizah, Sonia Hanifati, Sri Adi Sularsito, Lili Legiawati, Shannaz Nadia Yusharyahya, Rahadi Rihatmadja Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia / Dr. Cipto Mangunkusumo National General Hospital Keywords: porokeratosis, giant porokeratosis, paraneoplastic syndrome, nasopharyngeal Abstract: Giant porokeratosis is a rare condition in which the hyperkeratotic plaques of porokeratosis reach up to 20 cm in diameter. Porokeratosis is characterized clinically by hyperkeratotic papules or plaques with a thread-like elevated border. Although rare, porokeratosis has been reported in conjunction with malignancies suggesting a paraneoplastic nature. Associated malignancies reported were hematopoietic, hepatocellular, and cholangiocarcinoma. We report a case of giant porokeratosis in a patient with nasopharyngeal cancer responding to removal of the primary cancer by chemoradiotherapy. 1 INTRODUCTION regress completely after the treatment of malignancy, suggestive of paraneoplastic syndrome. Porokeratosis is a chronic progressive disorder of keratinization, characterized by hyperkeratotic papules or plaques surrounded by a thread-like 2 CASE elevated border corresponds to a typical histologic hallmark, the cornoid lamella . O regan, 2012) There Mr. SS, 68-year-old, was referred for evaluation of are at least six clinical variants of porokeratosis pruritic, slightly erythematous plaques with raised, recognized with known genetic disorder.1 Some hyperpigmented border of one and a half year clinical variant of porokeratosis has been reported in duration on the extensor surface of both legs. The the setting of immunosuppressive conditions, organ lesions shown minimal response to potent topical transplantation, use of systemic corticosteroids, and corticosteroids and phototherapy given during the infections, suggesting that impaired immunity may last 8 months in another hospital.
    [Show full text]
  • Features of Reactive White Lesions of the Oral Mucosa
    Head and Neck Pathology (2019) 13:16–24 https://doi.org/10.1007/s12105-018-0986-3 SPECIAL ISSUE: COLORS AND TEXTURES, A REVIEW OF ORAL MUCOSAL ENTITIES Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa Susan Müller1 Received: 21 September 2018 / Accepted: 2 November 2018 / Published online: 22 January 2019 © Springer Science+Business Media, LLC, part of Springer Nature 2019 Abstract White lesions of the oral cavity are quite common and can have a variety of etiologies, both benign and malignant. Although the vast majority of publications focus on leukoplakia and other potentially malignant lesions, most oral lesions that appear white are benign. This review will focus exclusively on reactive white oral lesions. Included in the discussion are frictional keratoses, irritant contact stomatitis, and smokeless tobacco keratoses. Leukoedema and hereditary genodermatoses that may enter in the clinical differential diagnoses of frictional keratoses including white sponge nevus and hereditary benign intraepithelial dyskeratosis will be reviewed. Many products can result in contact stomatitis. Dentrifice-related stomatitis, contact reactions to amalgam and cinnamon can cause keratotic lesions. Each of these lesions have microscopic findings that can assist in patient management. Keywords Leukoplakia · Frictional keratosis · Smokeless tobacco keratosis · Stomatitis · Leukoedema · Cinnamon Introduction white lesions including infective and non-infective causes will be discussed
    [Show full text]
  • Progressive Widespread Warty Skin Growths
    DERMATOPATHOLOGY DIAGNOSIS Progressive Widespread Warty Skin Growths Patrick M. Kupiec, BS; Eric W. Hossler, MD Eligible for 1 MOC SA Credit From the ABD This Dermatopathology Diagnosis article in our print edition is eligible for 1 self-assessment credit for Maintenance of Certification from the American Board of Dermatology (ABD). After completing this activity, diplomates can visit the ABD website (http://www.abderm.org) to self-report the credits under the activity title “Cutis Dermatopathology Diagnosis.” You may report the credit after each activity is completed or after accumu- lating multiple credits. A 33-year-old man presented with progres- sive widespread warty skin growths that had been present copysince 6 years of age. Physical examination revealed numerous verrucous papules on the face and neck along with Figure 1. H&E, original magnification ×40. Figure 2. H&E, original magnification ×40. verrucous, tan-pink papules and plaques diffuselynot scattered on the trunk, arms, and legs. A biopsy of a lesion on the neck Dowas performed. H&E, original magnification ×200. The best diagnosisCUTIS is: a. condyloma acuminatum b. epidermodysplasia verruciformis c. herpesvirus infection d. molluscum contagiosum e. verruca vulgaris PLEASE TURN TO PAGE 99 FOR DERMATOPATHOLOGY DIAGNOSIS DISCUSSION Mr. Kupiec is from the State University of New York (SUNY) Upstate Medical University, Syracuse. Dr. Hossler is from the Departments of Dermatology and Pathology, Geisinger Medical Center, Danville, Pennsylvania. The authors report no conflict of interest. Correspondence: Patrick M. Kupiec, BS, 50 Presidential Plaza, Syracuse, NY 13202 ([email protected]). 82 CUTIS® WWW.CUTIS.COM Copyright Cutis 2017. No part of this publication may be reproduced, stored, or transmitted without the prior written permission of the Publisher.
    [Show full text]
  • Inflammatory Skin Disease Every Pathologist Should Know
    Inflammatory skin disease every pathologist should know Steven D. Billings Cleveland Clinic [email protected] General Concepts • Pattern recognition – Epidermal predominant vs. dermal predominant • Epidermal changes trump dermal changes – Distribution of the inflammatory infiltrate • Superficial vs. superficial and deep • Location: perivascular, interstitial, nodular – Nature of inflammatory infiltrate • Mononuclear (lymphocytes and histiocytes) • Mixed (mononuclear and granulocytes) • Granulocytic • Correlation with clinical presentation • Never diagnose “chronic nonspecific dermatitis” Principle Patterns: Epidermal Changes Predominant • Spongiotic pattern • Psoriasiform pattern – Spongiotic and psoriasiform often co-exist • Interface pattern – Basal vacuolization • Perivascular infiltrate or • Lichenoid infiltrate Principle Patterns: Dermal Changes Predominant • Superficial perivascular • Superficial and deep perivascular • Interstitial pattern – Palisading granulomatous – Nodular and diffuse • Sclerosing pattern • Panniculitis • Bullous disease • Miscellaneous Spongiotic Dermatitis • Three phases – Acute – Subacute – Chronic • Different but overlapping histologic features Spongiotic Dermatitis • Acute spongiotic dermatitis – Normal “basket-weave” stratum corneum – Pale keratinocytes – Spongiosis – Spongiotic vesicles (variable) – Papillary dermal edema – Variable superficial perivascular infiltrate of lymphocytes often with some eosinophils – Rarely biopsied in acute phase Spongiotic Dermatitis • Subacute spongiotic dermatitis – Parakeratosis
    [Show full text]
  • Cutaneous Adverse Reaction to Infliximab: Report of Psoriasis Developing in 3 Patients
    THERAPEUTICS FOR THE CLINICIAN Cutaneous Adverse Reaction to Infliximab: Report of Psoriasis Developing in 3 Patients Gregg A. Severs, DO; Tara H. Lawlor, DO; Stephen M. Purcell, DO; Donald J. Adler, DO; Robert Thompson, MD Infliximab is a chimeric immunoglobulin G1k nfliximab is a chimeric immunoglobulin monoclonal antibody against tumor necrosis fac- G1k monoclonal antibody (75% human and tor a (TNF-a), a proinflammatory cytokine that I 25% mouse origin) against tumor necrosis participates in both normal immune function and factor a (TNF-a). It neutralizes the biologic activity the pathogenesis of many autoimmune disorders. of TNF-a by directly binding to soluble and trans- Treatment with infliximab reduces the biologic membrane TNF-a molecules in the plasma and activities of TNF-a and thus is indicated in the on the surface of macrophages and T cells in dis- treatment of rheumatoid arthritis, Crohn disease, eased tissue. The binding destroys these TNF-a ankylosing spondylitis, psoriatic arthritis, plaque molecules via antibody-dependent cellular toxicity psoriasis, and ulcerative colitis. and complement-dependent cytotoxic mechanisms. To our knowledge, there have been 13 case Thus, infliximab decreases the actions of TNF-a, reports of new-onset psoriasis, psoriasiform der- which include induction of proinflammatory cyto- matitis, and palmoplantar pustular psoriasis that kines such as interleukins (IL) 1 and 6; enhancement developed during treatment with infliximab. We of leukocyte migration by increasing endothelial layer report 3 additional cases of biopsy-proven new- permeability and expression of adhesion molecules onset psoriasis that developed while the patients by endothelial cells and leukocytes; activation of underwent treatment with infliximab for inflamma- neutrophil and eosinophil functional activity; induc- tory bowel disease.
    [Show full text]
  • Incidental Focal Acantholytic Dyskeratosis in the Setting of Rosacea
    Letter to the Editor http://dx.doi.org/10.5021/ad.2013.25.4.518 Incidental Focal Acantholytic Dyskeratosis in the Setting of Rosacea Sang-Yeon Park, Hae Jin Lee, Jae Yong Shin, Sung Ku Ahn Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea Dear Editor: direct immunofluorescence (Fig. 2). In the serial sections, Focal acantholytic dyskeratosis (FAD) was first described we observe the same findings. Differential diagnosis for by Ackerman1 in 1972 as a distinct histopathological pat- the possibility of polymorphous light eruption, systemic tern associated with various cutaneous conditions, and lupus erythematosus, contact dermatitis, and dermatitis with classic histopathological findings including supra- artefacta should be considered. But given these clinical basal clefting, hyperkeratosis and parakeratosis, and the and histopathological features, a diagnosis of rosacea with presence of acantholytic and dyskeratotic cells at the FAD was reached. The patient was then admitted to epidermis. While FAD can be observed in many various hospital for treatment with doxycycline 100 mg and cutaneous lesions including benign and/or malignant antihistamines. After one week, the lesions had remarka- epithelial lesions, fibrohistiocytic lesions, inflammatory bly improved. The patient was then discharged, and lesions, melanocytic and/or follicular lesions2-4. These continued on the same therapeutic regimen for an histopathological findings may also extend into the additional month, bythe time all lesions were nearly surrounding tissues, which often appear to be clinically resolved. normal. A 42-year-old woman was presented to our To date, the etiology of FAD has been attributed to department with multiple erythematous pruritic papules numerous sources including hormones, viral infection, and tiny vesicles on her face.
    [Show full text]
  • ECZEMA) Shankar Pratap K
    Research Article International Ayurvedi c Medical Journal ISSN:2320 5091 A HISTOPATHOLOGICAL STUDY ON LEECH APPLICATION IN THE MANAGEMENT OF VICARCIKA (ECZEMA) Shankar Pratap K. M.1 Rao Dattatreya 2 Sai Prasad 3 1Dept. of Shalya Tantra , Santhigiri Ayurvedic College , Palakkad, Kerala, India 2Dept. of Shalya Tantra, S.V. Ayurvedic College, Tirupati , Andhra Pradesh , India 3Dept. of Pathology, S. V. Medical College, Tirupati, Andhra Pradesh, India ABSTRACT To assess the efficacy of Leech application in the management of Vicarcik a (Eczema) with Histopathological study, the present study with 10 patients having the classical symptoms of Vicarcika, were randomly selected as per the inclusion and exclusion criteria from O.P.D. & I.P.D. sections of Shalya department, S.V. Ayurvedic Hospital, Tirupati. Minimum 4 sittings of Leech application was carried out with seven days interval. Total duration of treatment was 6 weeks. Biopsy samples were collected from the lesion site before and after treatment. Histopathological examination was done by the pathologist. In eczema (dermatitis) the leech application therapy gives excellent response by reducing the inflammatory component, hyperkeratosis, spongiosis, irregular acanthosis and by evoking a granulation tissue response in the dermis and in most of the cases with complete recovery from the lesion. Most of the cases in the study were chronic dermatitis and sebhoric keratosis, almost all local/focal pigmented lesion is totally relieved by leech therapy especially in cases of sebhoric keratos is. In the present study it was found that, leech application evokes significant changes at histological level specifically in reduction of inflammatory component, hyperkeratosis, spongiosis and irregular acanthosis.
    [Show full text]
  • Diffuse Drug-Induced Dermatitis Following Sclerotherapy for Telangiectasias Libby MW, Caitlin WH, Deniz OA and Heller JA*
    Case Report iMedPub Journals Journal of Vascular and Endovascular Surgery 2016 http://www.imedpub.com/ Vol.1 No.3:17 DOI: 10.21767/2573-4482.100017 Diffuse Drug-Induced Dermatitis following Sclerotherapy for Telangiectasias Libby MW, Caitlin WH, Deniz OA and Heller JA* Department of Surgery, Johns Hopkins Vein Center, Johns Hopkins Medical Centers, Baltimore, USA *Corresponding author: Jennifer A Heller, 10755 Falls Road, Pavilion 1 Suite 360, Lutherville, MD 21903, Tel: 4105500415; Email: [email protected] Received date: June 14, 2016; Accepted date: July 26, 2016; Published date: August 02, 2016 Copyright: © 2016 Libby MW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Sclerotherapy is an effective treatment modality for the management of lower extremity telangiectasias. Although localized dermatologic reactions are known complications of this procedure, systemic reactions are rare. Here, we present a case of a diffuse drug eruption following sclerotherapy for the treatment of bilateral lower extremity telangiectasias. Salient clinical and physical exam findings are described. Management strategies for the treatment of drug eruptions are outlined. This is the first case report that we know of describing a diffuse drug eruption associated with sclerotherapy. It is important to recognize the possibility of diffuse drug eruptions secondary to sclerotherapy treatment so that expectant management may be initiated expeditiously in affected patients. Figure 1: Drug eruption following sclerotherapy. The patient was referred for evaluation by a dermatologist, Case Report who initially diagnosed diffuse dermatitis based on clinical A 64-year-old woman with hypertension and bilateral lower exam.
    [Show full text]
  • JMSCR Vol||07||Issue||03||Page 281-286||March 2019
    JMSCR Vol||07||Issue||03||Page 281-286||March 2019 www.jmscr.igmpublication.org Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.51 Histopathological Evaluation of Collagen Profiles in Spongiotic Dermatitis Authors Anjali Patankar, Ramya Gandhi*, Erli Amel Ivan Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Puducherry, 605 107 India *Corresponding Author Dr Ramya Gandhi Associate Professor, Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Puducherry, 605 107, India Email: [email protected], Mobile no- 9787740891 Abstract Context: Spongiotic Dermatitis is a common clinical condition also known as eczema, characterized by rashes and itching further may progress to scarring. The terms eczema and dermatitis are often used interchangeably to denote a polymorphic inflammatory reaction pattern involving the epidermis and dermis. Spongiosis refers to intraepidermal edema. Aim: To assess the orientation of collagen in eczematous spongiotic dermatitis. Material and Methods: The present study was done in the Department of Pathology, Sri Manakula Vinayagar Medical College, Pondicherry. Sixty diagnosed cases of spongiotic dermatitis diagnosed over a period of five years were taken in the study. Orientation of collagen was evaluated using Masson’s trichrome stain. Results: Spongiotic dermatitis occurred in all age groups but commonly seen in middle age to elderly. Male to female ratio was 1:1.2 The most common symptom was itching (85%) followed by scaling (63.3%). Most common site was upper extremities (80%). subacute cases were predominantly seen (38.3%) followed by chronic cases (33.3%).
    [Show full text]
  • Trichoscopic Findings in Various Scalp Alopecias Unilateral Truncal Acne AEr Laminectomy Armoured Keloid Werner's Syndrome: a Rare EnTy
    JDA IJCD Indian Journal of Clinical Dermatology ` 800 - Jaipur Volume 2 | Issue 1 | May 2019 Four Monthly HIGHLIGHTS Sunscreens: The Current Scenario Trichoscopic Findings in Various Scalp Alopecias Unilateral Truncal Acne Aer Laminectomy Armoured Keloid Werner's Syndrome: A Rare Enty Clin of ica al l D rn e u r o m J a t n o a l i o d g n y I A Publication of Jaipur Dermatology Association Clin of ica JDA al l D rn e u r o m J a t n o INDIAN JOURNAL OF a l i o d g n y I CLINICAL DERMATOLOGY A Publication of Jaipur Dermatology Association EDITORIAL BOARD EDITORS DR. DINESH MATHUR DR. U S AGARWAL Prof & Head, Dept. of Skin, JNU Medical College Senior Professor, Ex. Sr. Prof & Head, Dept. of Skin, Dept. of Skin, STD & Leprosy STD & Leprosy, SMS Medical College Ex. Principal & Controller, Ex. Pro VC, RUHS SMS Medical College & Hospital, Jaipur Email: [email protected] Email: [email protected] EXECUTIVE EDITOR Dr. Puneet Agarwal Assistant Professor, Dept. of Skin, STD & Leprosy, SMS Medical College & Hospital, Jaipur Email: [email protected] ASSISTANT EDITORS Dr. Naushin Aara Assistant Professor Dept. of Skin, STD & Leprosy, SMS Medical College & Hospital, Jaipur Email: [email protected] Dr. Taniya Mehta Ex. Senior Resident Dept. of Skin, STD & Leprosy, SMS Medical College & Hospital, Jaipur Email: [email protected] JDA Indian Journal of Clinical Dermatology | Volume 02 | Issue 01 | May 2019 i Clin of ica JDA al l D rn e u r o m J a t n o INDIAN JOURNAL OF a l i o d g n y I CLINICAL DERMATOLOGY A Publication of Jaipur Dermatology Association Volume 02 | Issue 01 | August 2019 COPYRIGHT The entire contents of the Indian Journal of Clinical Dermatology are protected under Indian and International copyrights.
    [Show full text]
  • Review of the Literature
    Review Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature Gürkan Kaya 1,*, Aysin Kaya 2 and Jean-Hilaire Saurat 2 1 Departments of Dermatology and Clinical Pathology, University Hospital of Geneva, 1205 Geneva, Switzerland 2 Department of Clinical Pharmacology and Toxicology, University of Geneva, 1205 Geneva, Switzerland; [email protected] (A.K.); [email protected] (J.-H.S.) * Correspondence: [email protected] Received: 24 June 2020; Accepted: 29 June 2020; Published: 30 June 2020 Abstract: In recent weeks, several reports have emerged of skin lesions with different clinical presentations in COVID-19 cases. All dermatologists should be aware of these cutaneous lesions, which may be early clinical symptoms of infection. We reviewed the literature on cutaneous manifestations in the PubMed database from December 2019 and June 2020. From the cases described as case reports or series in 57 recent articles, it appears that skin lesions (i) are highly varied, (ii) may not be related to the severity of the condition and (iii) resolve spontaneously in a few days. The frequency of these lesions in COVID-19 patients varies between 1.8% and 20.4%. The major clinical forms described were maculopapular eruptions, acral areas of erythema with vesicles or pustules (pseudochilblain), urticarial lesions, other vesicular eruptions and livedo or necrosis. The lesions were mainly localized in the trunk and extremities. The majority of patients were male, aged between 4.5 and 89 years. A minority of the patients were children presenting with acral, chilblain-like lesions, papulo-vesicular eruptions or Kawasaki disease-like pediatric inflammatory multisystem syndrome.
    [Show full text]
  • Actinic Keratosis Squamous Cell Carcinoma in Situ
    Prepared by Kurt Schaberg Keratinocyte tumors Actinic Keratosis Precancerous , risk of malignancy ~8-20% per year (progresses to SCC); Due to chronic sun exposure Rough scaly plaque; typically due to sun exposure Tx : liquid nitrogen, 5-FU, shave, curettage • Atypical keratinocytes in lower third of epidermis • Alternating orthokeratosis and parakeratosis • Sparing of cutaneous adnexa • Solar elastosis in dermis Squamous cell carcinoma in situ (aka Bowen’s disease) • No epidermal maturation • Atypical cells at all levels of the epidermis Loss of granular layer • Epidermis appears disorganized Squamous Cell Carcinoma Second most common form of skin cancer (20% of cutaneous malignancies) Locally destructive; metastatic potential Tx: Depends on size, location and depth of invasion: Excision, Mohs micrographic surgery, Radiation • Nests of atypical squamous cells arise from the epidermis and invade the dermis • Evidence of squamous differentiation (keratinization and intercellular bridges) • Dyskeratotic cells = squamous differentiation Risk factors for metastasis (high risk): • Often associated with AK or SCCIS - location (ear, lip) • Findings that suggest invasion - size (>2 cm) • Jagged interface with dermis - depth • Aberrant deep keratinization - evidence of perineural invasion - evidence of desmoplastic • Single cells invasion features Variants: Keratoacanthoma - well-differentiated variant of SCC that spontaneously regresses in most cases. Typically composed of large, crateriform (cup-like) lesion filled with abundant keratin debris
    [Show full text]