Longevity.International Launch Event Virtual Webinar June 23 2021 5:00Pm - 8:00Pm BST Longevity.International Launch Event
Total Page：16
File Type：pdf, Size：1020Kb
Load more
Recommended publications
-
Biogerontology: a Novel Tool to Stay Healthy in Old Age
MoPAct Policy Brief: 5 Biogerontology: a novel tool to stay healthy in old age Policy priority Healthy lifestyle interventions in particular regarding nutrition and vaccination need to be implemented early in life with a lifecourse perspective. Summary: Key findings: • Accumulating evidence from experimental studies shows that aging is not inevitably linked with the development of chronic diseases. • Only 20-25% of healthy life expectancy (HLE) is predetermined by genes; lifestyle and environment play a major role. • Age-associated accumulation of molecular and cellular damage can be prevented or greatly delayed by lifestyle interventions e.g. dietary manipulations. • Classical strategies (e.g. nutrition, exercise, vaccination) require broad communication to public. • Novel strategies (e.g. dietary interventions, novel drugs, stem cells) need successful translation from the understanding of molecular mechanism to animal models to clinic. • To be successful interventions need to be started early Figure 1. Strategies to increase HLE. (1) Classical interventions include nutrition, exercise, vaccination, no smoking/alcohol/drugs. (2) Novel interventions include in life with a life-course perspective. dietary interventions, clearance of senescent and damaged cells, mitohormetics, stem cells, drugs against inflammation, rejuvenation factors from blood, telomeres, Background: epigenetic drugs, chaperons and proteolytic systems (novel interventions adapted from López-Otín et al., Cell 2013). Population aging is progressing fast in all developed countries. Aging is associated with the development of multiple serious chronic illnesses, including type 2 diabetes, hypertension, heart Prevention disease, stroke, cancer, cognitive impairment and increased Prevention prior to the development of age-associated diseases morbidity and mortality from infectious diseases. As people is key for successful aging. -
Supercentenarians Landscape Overview
Supercentenarians Landscape Overview Top-100 Living Top-100 Longest-Lived Top-25 Socially and Professionally Active Executive and Infographic Summary GERONTOLOGY RESEARCH GROUP www.aginganalytics.com www.grg.org Supercentenarians Landscape Overview Foreword 3 Top-100 Living Supercentenarians Overview 44 Preface. How Long Can Humans Live and 4 Ages of Oldest Living Supercentenarians by Country 46 the Importance of Age Validation Top-100 Living Supercentenarians Continental Executive Summary 10 47 Distribution by Gender Introduction. 26 Top-100 Living Supercentenarians Distribution by Age 50 All Validated Supercentenarians Сhapter III. Top-25 Socially and Professionally Active All Supercentenarians Region Distribution by Gender 29 52 Living Centenarians Top-25 Socially and Professionally Active Centenarians All Supercentenarians Distribution by Nations 30 53 Overview Top-25 Socially and Professionally Active Centenarians Longest-Lived Supercentenarians Distribution by Country 31 54 Distribution by Nation Top-25 Socially and Professionally Active Centenarians All Supercentenarians Distribution by Gender and Age 32 55 Gender Distribution Top-25 Socially and Professionally Active Centenarians Сhapter I. Top-100 Longest-Lived Supercentenarians 35 56 Distribution by Type of Activity Chapter IV. Profiles of Top-100 Longest-Lived Top-100 Longest-Lived Supercentenarians Overview 36 57 Supercentenarians Top-100 Longest-Lived Supercentenarians Regional 38 Chapter V. Profiles of Top-100 Living Supercentenarians 158 Distribution by Gender Top-100 Longest-Lived Supercentenarians Distribution by Chapter VI. Profiles of Top-25 Socially and Professionally 40 259 Age Active Living Centenarians and Nonagenarians Сhapter II. Top-100 Living Supercentenarians 43 Disclaimer 285 Executive Summary There have always been human beings who have lived well beyond normal life expectancy, these ‘supercentenarians’ who lived past 110 years of age. -
SENS-Research-Foundation-2019
by the year 2050, cardiovascular an estimated 25-30 the american 85 percent of adults disease years and older age 85 or older remains the most population will suffer from common cause of 2 1 2 dementia. death in older adults. triple. THE CLOCK IS TICKING. By 2030, annual direct The estimated cost of medical costs associated dementia worldwide was 62% of Americans with cardiovascular $818 billion diseases in the united over age 65 have in 2015 and is states are expected to more than one expected to grow to rise to more than chronic condition.1 3 $2 trillion $818 billion. by 2030.1 References: (1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732407/, (2) https://www.who.int/ageing/publications/global_health.pdf, (3) https://www.cdcfoundation.org/pr/2015/heart-disease-and-stroke-cost-america-nearly-1-billion-day-medical-costs-lost-productivity sens research foundation board of directors Barbara Logan Kevin Perrott Bill Liao Chairperson Treasurer Secretary Michael Boocher Kevin Dewalt James O’Neill Jonathan Cain Michael Kope Frank Schuler 02 CONTENTS 2019 Annual Report 04 Letter From The CEO 06 Outreach & Fundraising 08 Finances 09 Donors erin ashford photography 14 Education 26 Investments 20 Conferences & Events 30 Research Advisory Board 23 Speaking Engagements 31 10 Years Of Research 24 Alliance 32 MitoSENS 34 LysoSENS 35 Extramural Research 38 Publications 39 Ways to Donate cover Photo (c) Mikhail Leonov - stock.adobe.com special 10th anniversary edition 03 FROM THE CEO It’s early 2009, and it’s very late at night. Aubrey, Jeff, Sarah, Kevin, and Mike are sitting around a large table covered in papers and half-empty food containers. -
Died On: April 15, 2017 Place of Death: Verbania FAMOUS AS: SUPERCENTENARIAN
Carlo won the German Cuisine in a box. Thank you to Lynn & Dottie for donating. THANK YOU LODGE SISTER ROSE FOR THE GREAT PHOTOS Learning the Tarentella, Anne There was a Comedian to Entertain us. HAPPY BIRTHDAY TO LODGE SISTERS & BROTHERS CELEBRATING IN NOVEMBER Buon compleanno per alloggiare sorelle & fratelli che festeggiano nel Novembre Simonetta Stefanelli November 30, 1954 ROME, ITALY Simonetta Stefanelli is an Italian actress, entrepreneur and fashion designer. Internationally, she is best known for her performance as Apollonia Vitelli-Corleone in the 1972 film The Godfather, directed by Francis Ford Coppola. Her other roles include appearances in Moses the Lawgiver, Scandal in the Family and Three Brothers. In 1992, Stefanelli made her last film appearance in the drama Le amiche del cuore directed by her then husband Michele Placido. AN ITALIAN ACTRESS BORN IN ROME, SIMONETTA STEFANELLI MADE HER FIRST APPEARENCE IN LA MOGLIE GIAPPONESE AND APPEARED IN SEVERAL ITALIAN FILMS BEFORE APPEARING IN HER FIRST INTERNATIONAL ROLE IN THE GODFATHER, AS APOLLONIA, AT THE AGE OF 16. Simonetta Stefanelli was born on November 30, 1954, in Rome, Lazio, Italy. She started acting in Italian movies as a child artist and was about 16 years old when she was offered the role of ‘Apollonia Vitelli– Corleone’ in the movie ‘The Godfather.’ After her performance in ‘The Godfather,’ she received numerous offers from Hollywood which she turned down, as she feared being stereotyped as a sex symbol. She preferred to continue with her career in Italy and appeared in a number of TV serials and movies, such as ‘The King is the Best Mayor,’ ‘The Big Family,’ and ‘Moses the Lawgiver. -
Shared Ageing Research Models (Sharm): a New Facility to Support Ageing Research
Biogerontology (2013) 14:789–794 DOI 10.1007/s10522-013-9457-0 METHOD Shared Ageing Research Models (ShARM): a new facility to support ageing research Adele L. Duran • Paul Potter • Sara Wells • Tom Kirkwood • Thomas von Zglinicki • Anne McArdle • Cheryl Scudamore • Qing-Jun Meng • Gerald de Haan • Anne Corcoran • Ilaria Bellantuono Received: 5 July 2013 / Accepted: 16 August 2013 / Published online: 2 October 2013 Ó The Author(s) 2013. This article is published with open access at Springerlink.com Abstract In order to manage the rise in life expec- Wellcome Trust, open to all investigators. It collects, tancy and the concomitant increased occurrence of stores and distributes flash frozen tissues from aged age-related diseases, research into ageing has become murine models through its biorepository and provides a strategic priority. Mouse models are commonly a database of live ageing mouse colonies available in utilised as they share high homology with humans and the UK and abroad. It also has an online environment show many similar signs and diseases of ageing. (MICEspace) for collation and analysis of data from However, the time and cost needed to rear aged communal models and discussion boards on subjects cohorts can limit research opportunities. Sharing of such as the welfare of ageing animals and common resources can provide an ethically and economically endpoints for intervention studies. Since launching in superior framework to overcome some of these issues July 2012, thanks to the generosity of researchers in but requires dedicated infrastructure. Shared Ageing UK and Europe, ShARM has collected more than Research Models (ShARM) (www.ShARMUK.org) 2,500 tissues and has in excess of 2,000 mice regis- is a new, not-for-profit organisation funded by tered in live ageing colonies. -
Viewer Comments
Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Graphical abstract Authors Christopher D. Wiley, Rishi Sharma, Sonnet S. Davis, ..., Marco Demaria, Arvind Ramanathan, Judith Campisi Correspondence [email protected] (C.D.W.), [email protected] (A.R.), [email protected] (J.C.) In brief Senolytics, transgenic, and pharmacological interventions that selectively kill senescent cells are currently in clinical trials aiming to treat age-related degenerative pathologies. Here, Wiley et al. discover that senescent cells produce multiple signaling lipids known as oxylipins. One oxylipin, dihomo-15d-PGJ2, promotes features of senescence by activating RAS and is released from cells during senolysis, serving as the first biomarker of the Highlights process in culture and in vivo. d Senescent cells make several oxylipins, dihomo- prostaglandins, and leukotrienes d Dihomo-15d-PGJ2 is intracellular during senescence and released during senolysis d Dihomo-15d-PGJ2 activates RAS, promoting senescence and the SASP d Positive feedback between prostaglandins, RAS, and p53 maintains senescence Wiley et al., 2021, Cell Metabolism 33, 1–13 June 1, 2021 ª 2021 Published by Elsevier Inc. https://doi.org/10.1016/j.cmet.2021.03.008 ll Please cite this article in press as: Wiley et al., Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis, Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.03.008 ll Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Christopher D. Wiley,1,2,* Rishi Sharma,1 Sonnet S. Davis,1 Jose Alberto Lopez-Dominguez,1 Kylie P. Mitchell,1 Samantha Wiley,1 Fatouma Alimirah,1 Dong Eun Kim,1 Therese Payne,1 Andrew Rosko,1 Eliezer Aimontche,1 Sharvari M. -
NEBRASKA's CENTENARIANS AGE 107 OR ABOVE — 1867 to 2001
NEBRASKA’S CENTENARIANS AGE 107 OR ABOVE — 1867 to 2001 by E. A. Kral May 1, 2014 update of original published in The Crete News, April 24, 2002, a 40-page supplement Public Announcement for All Nebraskans Effective May 1, 2002, the Nebraska Health Care Association initiated two on-going public service projects on its website to highlight Nebraskans who reach age 107 or above. The NHCA website address is www.nehca.org. First, the NHCA has maintained a roster of living Nebraskans who have attained the age of 107 or above that provides name, birth date, and county in which the person resides. Second, the NHCA has made available access to this updated manuscript version of E. A. Kral’s “Nebraska’s Centenarians Age 107 or Above — 1867 to 2001” but without photographs. Moreover, it has also offered a brief on-going ranking of Nebraska’s supercentenarians in state history, and another document titled “Oldest Twins in Nebraska History.” Relatives, healthcare professionals, and others are asked to notify the NHCA when someone with Nebraska connections reaches age 107 for placement of name, birth date, and county of residence on the living roster. Since age verification may be necessary via census records involving the centenarian’s youth or early adult years, relatives may assist by providing names of parents and location of centenarian during 1900 to 1920. Also please notify the NHCA when the persons on the living roster become deceased so that the roster may be current. The NHCA website address is www.nehca.org and referrals for the living 107-year-old roster may be mailed to Nebraska Health Care Association, 1200 Libra Dr., Ste 100, Lincoln, NE 68512-9332. -
HCB 524 — Transhumanism
HCB 524 Special Topic in Bioethics Fall Semester, 2019. Tuesdays 6-8:30pm. Instructor of Record: Adam Sepe, MA, MLS(ASCP)cm [email protected] Course Description: Transhumanism and [Human?] Dignity. Throughout human history — and prehistory for that matter — technological advancement has drastically altered every aspect of human life. Most of us will say that many advents — such as cooking and the wheel — have been largely, if not entirely, beneficial. Would we say the same of all technology? Surely each of us can list technologies that have, in the very least, some considerable downsides. So while history and experience can tell us that some technologies are beneficial and that some other technologies are harmful, how can we know what kind of impact future technology will have? For now we can’t, and so all we can do is try, to the best of our ability, to imagine such futures and develop our technology with these considerations in mind. ‘Transhumanism’ refers a diverse collection of ideas that have one at least thing in common: through future technology, humanity will be fundamentally altered to an unprecedented degree. Some even believe there will come a time when, through our own action, the word ‘human’ will be obsolete; that we will be succeeded by entities (or an entity) for which ‘human’ does not apply. Most people who identify as transhumanists are, to varying degrees, proponents of such technology. They are in favor of such alterations and they argue that these will be beneficial. In this course, we will take a critical look at transhumanist claims. -
Searching for the Secrets of the Super Old More and More People Are Living Past 110
NEWSFOCUS AGING Searching for the Secrets Of the Super Old More and more people are living past 110. Can they show us all how to age gracefully? They were born when the years still started Perls of Boston University with “18.” They survived global traumas such School of Medicine, head as World War I, World War II, and the Great of the New England Cen- Depression. They didn’t succumb to pan- tenarian Study and its new demic flu, polio, AIDS, Alzheimer’s disease, National Institutes of or clogged arteries. Supercentenarians, or Health–funded spinoff, the people who’ve survived to at least age 110, are New England Supercente- longevity champions. narian Study. Researchers suspect that some Living to 100 is unlikely enough. Accord- of the oldsters included in the tally had already he requires three types of verification: proof ing to one estimate, about seven in 1000 peo- died and that others—or their relatives—were of birth, preferably a birth certificate; proof ple reach the century milestone. And at that lying about their ages. Drawing on Medicare of death, if the person is no longer alive; and age, the odds of surviving even one more year enrollment figures, two U.S. government “continuity” documentation, such as a dri- are only 50–50, says James Vaupel, director of actuaries put the number of supercentenarians ver’s license or marriage certificate, that the Max Planck Institute for Demographic in the year 2000 at a mere 105. And in 2002, shows that the putative supercentenarian is Research in Rostock, Germany. Making it 139 people claiming to be at least 110 were the person listed in the birth record. -
Syllabus 2018
FINAL DRAFT Summer One Semester 2018 HCB 504 BIOTECHNOLOGY: Special Topics Room 067 Mondays, Tuesday, Thursdays 6 – 8:30 pm Instructor of Record: Migdal, Kobba, Post Phyllis Migdal, MD MA [email protected] Timothy Kobba MA [email protected] Stephen Post PhD [email protected] Course Description: Dignity and Biomedical Aspirations – Therapy, Enhancement & Transhumanism The three “supers” of transhumanism are not just “science fiction.” Super-longevity, super-happiness, and super-intelligence, along with perfect babies, are works-in-progress at the interface of “old” evolved human nature as we have known it and technical progress toward the posthuman of our own creation. With the astonishing biotechnological powers that are increasingly reshaping nature and human nature, are we in a “transitional state” (transhumanism) en route to a redesigned posthuman future in which current limitations are overcome? Four centuries ago, Francis Bacon announced the biological utopia of the future in his The New Atlantis, replete with fountains of youth and chimeras. The term “transhumanism” was originally coined by the British biologist philosopher Julian Huxley in a 1957 essay to capture the ways in which social institutions could supplant evolution in refining and improving the species, as could technology. Sensory perception, emotive ability, cognitive capacity, health and life spans could all be augmented. The term was taken over in the 1990s by British philosopher Max More, who began defining the principles -
Longevity Fitness Financial and Health Dimensions Across the Life Course Advisory Board TABLE OF
Longevity Fitness Financial and Health Dimensions Across the Life Course Advisory Board TABLE OF Peter A. Lichtenberg, PhD, Mary D. Naylor, PhD, RN, FAAN Surya Kolluri, MBA ABPP, FGSA, Chair Marian S. Ware Professor in Gerontology Managing Director, Policy, Planning, and Thought Leadership CONTENTS Director, Institute of Gerontology Director, NewCourtland Center for Director, Merrill Palmer Skillman Institute Transitions and Health Retirement and Personal Wealth Solutions Distinguished University Service Professor School of Nursing Bank of America Professor, Department of Psychology University of Pennsylvania Wayne State University Philadelphia, Pennsylvania Detroit, Michigan Milind M. Shrikhande, Michael Finke, PhD, CFP PhD, MBA Professor of Wealth Management Clinical Professor, Department of Finance Program Director, Wealth Management J. Mack Robinson College of Business Certified Professionals Georgia State University Frank M. Engle Distinguished Chair in Atlanta, Georgia Economic Security The American College of Financial Services Bryn Mawr, Pennsylvania Acknowledgments This report was developed by The Gerontological Society of America and supported by Bank of America. About The Gerontological Society of America and National Academy on an Aging Society The Gerontological Society of America (GSA) is the oldest and largest international, interdisciplinary scientific organization devoted to research, education, and practice in the field of aging. The principal mission of the Society—and its 5,500+ members—is to advance the study of aging and disseminate information among scientists, decision makers, and the general public. GSA’s policy institute, the National Academy on an Aging Society, conducts and compiles research on issues related to population aging and provides information to the public, the press, policymakers, and the academic community. -
Chapter 9. Myths of Life Extension
Chapter 9. Myths of Life Extension Ever since humans became fully aware that they will get old and die, individuals must have wondered about the possibility of extending longevity, or achieving immortality on earth. This has resulted in innumerable myths relating to supposed examples of life-extension, one of the most notable being the 969 year lifespan of Methuselah, as recorded in the Bible. Christian fundamentalists are liable to say that in those days people lived much longer than they do today! These are many other claims, and far too many to list here. The Guiness Book of Records has stated that maximum lifespans of people and animals are some of the hardest records to document. Some of the claims of human longevity have occurred in the 20th century, and as in some cases they were initially accepted by scientists, and they provide good examples of how people are deceived. Many people living in the Caucasus region of the ex-Soviet Union claimed their ages were over 120 years, or even 160 years. There was even a touring troup of centenarian dancers, so it is not surprising the claims received wide publicity, and also wide acceptance. The oldest people were usually males which is intrinsically unlikely as human females live longer that males. Careful scrutiny of these cases, particularly by the gerontologist Zhores Medvedev, has shown that none are backed up by reliable records. In some cases, individuals took on the identity of their father, in others they exaggerated their age to escape military conscription, or they simply added on years, because the societies in which they lived respected the wisdom and experience of very old people.