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UCSF UC San Francisco Previously Published Works Title Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Permalink https://escholarship.org/uc/item/5h1736nk Authors Glasgow, Anum Glasgow, Jeff Limonta, Daniel et al. Publication Date 2020-08-04 DOI 10.1101/2020.07.31.231746 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 Anum Glasgowa,1 , Jeff Glasgowb,1 , Daniel Limontac,d , Paige Solomonb, Irene Luib , Yang Zhanga , Matthew A. Nixe , Nicholas J. Rettkob , Shoshana Zhaf , Rachel Yaming, Kevin Kaog, Oren S. Rosenbergf , Jeffrey V. Ravetchg , Arun P. Wiitae , Kevin K. Leungb , Shion A. Limb , Xin X. Zhoub , Tom C. Hobmanc,d,h , Tanja Kortemmea, and James A. Wellsb,i,2 aDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158; bDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; cLi Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada; dDepartment of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada; eDepartment of Laboratory Medicine, University of California, San Francisco, CA 94143; fDepartment of Medicine, University of California, San Francisco, CA 94143; gLaboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10065; hDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2R3, Canada; and iDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158 Edited by David Baker, University of Washington, Seattle, WA, and approved September 29, 2020 (received for review July 31, 2020) An essential mechanism for severe acute respiratory syndrome (ACE2) to enter human cells (3, 4, 8).
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