DOCSLIB.ORG

PHENOLIC COMPOUNDS and PARTHENOLIDE PRODUCTION from in Vitro CULTURES of Tanacetum Parthenium Revista Mexicana De Ingeniería Química, Vol

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
PHENOLIC COMPOUNDS and PARTHENOLIDE PRODUCTION from in Vitro CULTURES of Tanacetum Parthenium Revista Mexicana De Ingeniería Química, Vol Revista Mexicana de Ingeniería Química ISSN: 1665-2738 [email protected] Universidad Autónoma Metropolitana Unidad Iztapalapa México Nieto-Trujillo, A.; Buendía-González, L.; García-Morales, C.; Román-Guerrero, A.; Cruz- Sosa, F.; Estrada-Zúñiga, M.E. PHENOLIC COMPOUNDS AND PARTHENOLIDE PRODUCTION FROM in vitro CULTURES OF Tanacetum parthenium Revista Mexicana de Ingeniería Química, vol. 16, núm. 2, 2017, pp. 371-383 Universidad Autónoma Metropolitana Unidad Iztapalapa Distrito Federal, México Available in: http://www.redalyc.org/articulo.oa?id=62052087004 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative Vol. 16, No. 2 (2017) 371-383 Revista Mexicana de Ingeniería Química PHENOLIC COMPOUNDS AND PARTHENOLIDECONTENIDO PRODUCTION FROM in vitro CULTURES OF Tanacetum parthenium Volumen 8, número 3, 2009 / Volume 8, number 3, 2009 ´ ´ PRODUCCI ON DE COMPUESTOS FENOLICOS Y PARTENOLIDA EN CULTIVOS in vitro DE Tanacetum parthenium 213 DerivationA. and Nieto-Trujillo application of1 ,the L. Stefan-Maxwell Buend´ıa-Gonz equationsalez´ 2, C. Garc´ıa-Morales2, A. Roman-Guerrero´ 1, F. Cruz-Sosa1*, M.E. Estrada-Zu´niga˜ 3 1Departamento de(Desarrollo Biotecnolog´ıa,Universidad y aplicación de las ecuaciones Aut´onomaMetropolitana-Iztapalapa. de Stefan-Maxwell) Av. San Rafael Atlixco N° 186, Col. Stephen Whitaker Vicentina C.P. 09340, M´exicoD.F. 2 Facultad de Ciencias, Universidad Aut´onomadel Estado de M´exico,Campus El Cerrillo, Piedras Blancas. Carretera Toluca-Ixtlahuaca Km. 15.5, C.P. 50200, Toluca, Estado de M´exico,M´exico. 3Centro de Investigaci´onenBiotecnología Recursos / Biotechnology Bi´oticos-Facultad de Ciencias, Universidad Aut´onomadel Estado de M´exico,Carretera Toluca-Ixtlahuaca Km 14.5, San Cayetano C.P. 50295, Toluca, Estado de M´exico,M´exico. 245 Modelado de la biodegradación en biorreactores de lodos de hidrocarburos totales del petróleo Received December 28, 2016; Accepted February 28, 2017 intemperizados en suelos y sedimentos Abstract (Biodegradation modeling of sludge bioreactors of total petroleum hydrocarbons weathering in soil Tanacetum parthenium has gained attention for drug development due to its production of bioactive secondary metabolites, and sediments) such as phenolic compounds (PHEC) and parthenolide (PTN). This work investigated the differences in the production of those compoundsS.A. among Medina-Moreno,in vitro cultures S. Huerta-Ochoa, (organs from C.A. plantlets Lucho-Constantino, and roots cultures) L. Aguilera-Vázquez, of T. parthenium A. Jiménez-. Results showed that the in vitro culturesGonzález produced y M. Gutiérrez-Rojas PHEC and PTN, which depended on the type of culture and the incubation time. The content of secondary259 Crecimiento, metabolites sobrevivencia was higher y in adaptación shoots of de plantlets Bifidobacterium (S-ivPL), infantis followed a condiciones by root cultures ácidas (R-ivC) and roots of plantlets (R-ivPL). The PHEC and PTN production was enhanced in plantlets by applying a combination of plant growth regulators (PGRs: (Growth,α-naphtalenacetic survival and acid adaptation [NAA] of atBifidobacterium 0.27 µM with infantis kinetin to acidic [KIN] conditions) at 2.32 µ M). The highest content of secondary metabolitesL. Mayorga-Reyes, (62.54 mg gallic P. acidBustamante-Camilo, equivalents g− 1A.; 4.261Gutiérrez-Nava, and 4.973 E. mg Barranco-Florido chlorogenic acid y gA.−1 ;Azaola- 0.858 and 1.015 − − − mg caffeic acid g Espinosa1; 1.931 mg salicylic acid g 1; 0.071 mg PTN g 1) was found in the PGRs-treated S-ivPL samples. Also, morphogenesis265 Statistical and growth approach of plantlets to optimization was enhanced of ethanol by these fermentation PGRs. by Saccharomyces cerevisiae in the Keywords: Tanacetum parthenium, parthenolide, phenolic compounds, in vitro cultures, bioactive secondary metabotiles presence of Valfor® zeolite NaA Resumen Tanacetum parthenium (Optimizaciónha ganado estadística la atenci deon´ la para fermentación el desarrollo etanólica de f armacos´de Saccharomyces por su capacidad cerevisiae para en presencia producir de metabolitos secundarios bioactivos,zeolita tales Valfor® como zeolite compuestos NaA) fenolicos´ (CFEN) y partenolida (PTN). El presente trabajo investigo´ las diferencias en la produccion´ de dichos metabolitos entre cultivos in vitro (organos´ de plantulas´ y cultivos de ra´ıces) de G. Inei-Shizukawa, H. A. Velasco-Bedrán, G. F. Gutiérrez-López and H. Hernández-Sánchez T. parthenium. Los resultados mostraron que los cultivos in vitro produjeron CFEN y PTN, la cual dependio´ del tipo de cultivo y del tiempo de incubacion.´ El contenido de los metabolitos secundarios fue mayor en brotes de plantulas´ (B-ivPL), seguido de cultivosIngeniería de ra de´ıces procesos (R-ivC) / Process y ra´ıces engineering de plantulas´ (R-ivPL). La produccion´ de CFEN y PTN fue potenciada en las plantulas´ al271 aplicar Localización una combinaci de una on´planta de reguladoresindustrial: Revisión de crecimiento crítica y vegetaladecuación (RCVs: de losacido´ criteriosα-naftalenac empleadosetico´ en 0.27 µM −1 y cinetina 2.32 µM.esta Los decisión mejores contenidos de metabolitos secundarios (62.54 mg equivalentes de acido´ galico´ g de fenoles totales; 4.261 y 4.973 mg acido´ clorogenico´ g−1; 0.858 y 1.015 mg acido´ cafeico g−1; 1.931 mg acido´ salic´ılico (Plant site selection: Critical review and adequation criteria used in this decision) g−1; 0.071 mg PTN g−1) fueron encontrados en B-ivPL tratados con RCVs. Tambien,´ la morfogenesis´ y el crecimiento de J.R. Medina, R.L. Romero y G.A. Pérez las plantulas´ fueron potenciadas con los RCVs. Palabras clave : Tanacetum parthenium, compuestos fenolicos,´ partenolida, cultivos in vitro, metabolitos secundarios bioactivos. * Corresponding author. E-mail: mail: [email protected] Tel. 52-55-5804-4714; fax: 52-55-5804-4712 Publicado por la Academia Mexicana de Investigacion´ y Docencia en Ingenier´ıa Qu´ımica A.C. 371 Nieto-Trujillo et al./ Revista Mexicana deIngenier ´ıaQu ´ımica Vol. 16, No. 2 (2017) 371-383 1 Introduction effects against cancer, diabetes, cardiovascular and neurodegenerative diseases (Pisoschi and Pop, 2015). Tanacetum parthenium (L.) Schultz-Bip (Asteraceae) In T. parthenium, the content of total phenolic is a species that has gained great attention for compounds from extracts affects the antioxidant drug development, based on its outstanding uses in activity (Wu et al., 2006). However, it is well known folk medicine against migraine, asthma, rheumatoid that the production of secondary metabolites in arthritis, gynecological problems, insect bites, plants is regulated by different factors (Karuppusamy psoriasis and fevers (Awang et al., 1991; Pareek 2009; Verpoorte et al., 2002). In T. parthenium, the et al., 2011). Pharmacological and phytochemical production of parthenolide depends on the organ used studies on this species have contributed to validate to obtain extracts, stages of cultivation, environmental scientifically its medicinal potential (e.g. on cancer, factors, genotype and developmental stage (Awang migraine, inflammatory diseases, etc.) (Andonova 1991; Fonseca et al., 2005; Heptinstall et al., 1992; et al., 2016; Eardie et al., 1992; Ernst and Pittler Hojati et al., 2016; Majdi et al., 2013, 2015). 2000; Ferro et al., 2012; Pfaffenrath et al., 2002). Plant tissue and organ culture has become The phytochemical results have elucidate bioactive a feasible biotechnological technique to produce compounds belonging to terpenoid (essential oils bioactive compounds since it allows controlling the and sesquiterpene lactones) and phenolic (flavonoids, conditions to produce secondary metabolites and phenolic acids and coumarins) secondary metabolites morphogenesis (Dias et al. 2016). Reports about in type (Majdi et al., 2011; Pareek et al., 2011; Wu vitro cultures of T. parthenium have demonstrated et al., 2006). Sesquiterpene lactones are one of that the production of parthenolide is affected by the the most important biologically active principles; type of cultured tissue, carbon source, PGRs and more than 30 types of them have been identified, chemicals (El-Shamy et al., 2007; Rateb et al., 2007; being PTN the most abundant (Pareek et al., 2011; Stojakowska and Kisiel 1997). Furthermore, it has Cretnik 2005). PTN exerts cytotoxic activity against been determined that in vitro cultures of T. parthenium several human cancer cell lines (e.g. breast, leukemia, can produce other types of secondary metabolites. osteosarcoma, human cervical) (Al-Fatlawi et al., In hairy root cultures, dyacetylenes and coumarins 2015; D’Anneo et al., 2013; Lesiak et al., 2010; Pei et (Stojakowska et al., 2002, 2008) have been identified, al., 2012). Its mechanism of action has been associated while in callus coniferaldehyde derivatives (Sy and with the inhibition of growth and the induction of Brown 1999) and coumarin isofraxidin are detected apoptosis without having an effect on normal cells (Banthorpe and Brown 1990). However, there is no (Al-Fatlawi et al., 2015; Cijo et al., 2012; Mathema et evidence reporting the simultaneous production of al., 2012). Additional biological effects have been parthenolide and phenolic compounds from in vitro described for PTN, which includes antimigraine cultures of T. parthenium. The aim of the present (Tassorelli et al., 2005), anti-inflammatory
Load more

Recommended publications
  • Aspects of Physiology and Trichome Chemistry in the Medicinal Plant
    Aspects of Physiology and Trichome Chemistry in the Medicinal Plant Tanacetum parthenium (L.) Schultz-Bip. by Kevin Bernard Usher B.Sc, Okanagan University College, 1994 A THESIS SUBMITTED IN PARTIAL FULLFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE STUDIES DEPARTMENT OF BOTANY We accept this thesis as conforming to the required standard G.H.N. Towers, Supervisor (Botany, University of British Columbia) .E.P. Taylor, Co^ipen/isor (Botany, University of British Columbia) P.A. Bowen, Committee Member (Pacific Agriculture Research Center, Agriculture and Agri-Food Canada) A.D./vKala^s, Commit$e4v1ember (Botany, University of British Columbia) THE UNIVERSITY OF BRITISH COLUMBIA September 2001 © Kevin Bernard Usher, 2001 In presenting this thesis in partial fulfilment of the requirements for an advanced degree at the University of British Columbia, I agree that the Library shall make it freely available for reference and study. I further agree that permission for extensive copying of this thesis for scholarly purposes may be granted by the head of my department or by his or her representatives. It is understood that copying or publication of this thesis for financial gain shall not be allowed without my written permission. Department The University of British Columbia Vancouver, Canada Date S" Oct , Zoo( DE-6 (2/88) 11 ABSTRACT This study investigated aspects of physiology and terpenoid chemistry in feverfew, a medicinal plant used for migraine therapy. The sesquiterpene lactone parthenolide accumulates in feverfew shoots and is thought to contribute to feverfew's antimigraine activity. The first part of this study examined the effects of nitrogen application and irrigation on shoot yield and shoot parthenolide concentration.
    [Show full text]
  • Assessment Report on Tanacetum Parthenium (L.) Schultz Bip., Herba. Draft
    25 September 2019 EMA/HMPC/48716/2019 Committee on Herbal Medicinal Products (HMPC) Assessment report on Tanacetum parthenium (L.) Schultz Bip., herba Draft – Revision 1 Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC (traditional use) Herbal substance(s) (binomial scientific name of the plant, including plant part) Tanacetum parthenium (L.) Schultz Bip., herba Herbal preparation Powdered herbal substance Pharmaceutical form(s) Herbal preparation in solid dosage forms for oral use First assessment Rapporteur G Calapai Peer-reviewer B Kroes Revision Rapporteur A Assisi Peer-reviewer B Kroes Note: This draft assessment report is published to support the public consultation of the draft European Union herbal monograph on Tanacetum parthenium (L.) Schultz Bip., herba. It is a working document, not yet edited, and shall be further developed after the release for consultation of the monograph. Interested parties are welcome to submit comments to the HMPC secretariat, which will be taken into consideration but no ‘overview of comments received during the public consultation’ will be prepared on comments that will be received on this assessment report. The publication of this draft assessment report has been agreed to facilitate the understanding by Interested Parties of the assessment that has been carried out so far and led to the preparation of the draft monograph. Official address Domenico Scarlattilaan 6 ● 1083 HS Amsterdam ● The Netherlands Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 An agency of the European Union © European Medicines Agency, 2019.
    [Show full text]
  • Infraspecific Variability in the Flavonoid Composition of Artemisia Vulgaris L
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE Acta Bot. Croat. 65 (1), 13–18, 2006 CODEN: ABCRA25 ISSN 0365–0588 Infraspecific variability in the flavonoid composition of Artemisia vulgaris L. MILENA NIKOLOVA* Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev str. 1113 Sofia, Bulgaria Surface flavonoid profiles in forty populations of Artemisia vulgaris L. (Asteraceae) were analyzed. The major constituents observed in the leaf exudates were methylated flavonoid aglycones based mainly on quercetin. Three infraspecific flavonoid chemotypes were de- termined, the chrysosplenetin (quercetagetin 3,6,7,3’-tetramethyl ether) chemotype, the artemetin (quercetagetin 3,6,7,3’,4’-pentamethyl ether) chemotype and chemotype with- out these two compounds. Most of the populations corresponded to these chemotypes. Key words: Artemisia vulgaris, Asteraceae, flavonoid aglycones, chrysosplenetin, arte- metin, chemotype Introduction Surface flavonoid aglycones are often used in chemotaxonomic studies on Asteraceae at the generic and species level (VALANT-VETSCHERA and WOLLENWEBER 1996, WOLLEN- WEBER et al. 1997, STEVENS et al. 1999). Recent articles showed that a flavonoid pattern couldalsobespecificforachemotype(REP^ÁK et al. 1999, WILLIAMS et al. 2000, MARTONFI et al. 2001, VIEIRA et al. 2003). The species of the genus Artemisia (Asreraceae) have been extensively surveyed for their surface flavonoid constituents (WOLLENWEBER et al. 1989, VALANT-VETSCHERA and WOLLENWEBER 1995, WOLLENWEBER and VALANT-VETSCHERA 1996). Artemisia vulgaris L (Asteraceae) is a perennial polymorphic species, widespread in temperate areas (South Europe, North Africa, North America and Asia). Simple flavonol methyl ethers have been reported for West-European populations (VALANT-VETSCHERA et al.
    [Show full text]
  • Shilin Yang Doctor of Philosophy
    PHYTOCHEMICAL STUDIES OF ARTEMISIA ANNUA L. THESIS Presented by SHILIN YANG For the Degree of DOCTOR OF PHILOSOPHY of the UNIVERSITY OF LONDON DEPARTMENT OF PHARMACOGNOSY THE SCHOOL OF PHARMACY THE UNIVERSITY OF LONDON BRUNSWICK SQUARE, LONDON WC1N 1AX ProQuest Number: U063742 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a com plete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest ProQuest U063742 Published by ProQuest LLC(2017). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States C ode Microform Edition © ProQuest LLC. ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106- 1346 ACKNOWLEDGEMENT I wish to express my sincere gratitude to Professor J.D. Phillipson and Dr. M.J.O’Neill for their supervision throughout the course of studies. I would especially like to thank Dr. M.F.Roberts for her great help. I like to thank Dr. K.C.S.C.Liu and B.C.Homeyer for their great help. My sincere thanks to Mrs.J.B.Hallsworth for her help. I am very grateful to the staff of the MS Spectroscopy Unit and NMR Unit of the School of Pharmacy, and the staff of the NMR Unit, King’s College, University of London, for running the MS and NMR spectra.
    [Show full text]
  • Extracts of Feverfew (Tanacetum Parthenium)
    Europäisches Patentamt *EP001100516B1* (19) European Patent Office Office européen des brevets (11) EP 1 100 516 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.7: A61K 35/78, A61P 29/00 of the grant of the patent: 23.03.2005 Bulletin 2005/12 (86) International application number: PCT/US2000/015125 (21) Application number: 00938038.7 (87) International publication number: (22) Date of filing: 02.06.2000 WO 2000/074699 (14.12.2000 Gazette 2000/50) (54) EXTRACTS OF FEVERFEW (TANACETUM PARTHENIUM) AGAINST INFLAMMATORY DISORDERS EXTRAKTE VON MUTTERKRAUT (TANACETUM PARTHENIUM) GEGEN ENTZÜNDLICHE ERKRANKUNGEN EXTRAITS DE CHRYSANTEME-MATRICAIRE (TANACETUM PARTHENIUM) UTILISES CONTRE LES TROUBLES INFLAMMATOIRES (84) Designated Contracting States: • ODDOS, Thierry AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU F-92190 Meudon (FR) MC NL PT SE • GENDIMENICO, Gerard, J., Neshanic Station, NJ 08853 (US) (30) Priority: 03.06.1999 US 137332 P • MARTIN, Katharine Ringoes, NJ 08551 (US) (43) Date of publication of application: 23.05.2001 Bulletin 2001/21 (74) Representative: Ahner, Francis et al Cabinet Régimbeau (73) Proprietors: 20, rue de Chazelles • Johnson & Johnson Consumer France SAS 75847 Paris cedex 17 (FR) 92787 Issy les Moulineaux Cedex 9 (FR) • Callaghan, Theresa (56) References cited: 2613 AX Delft (NL) • DATABASE BIOSIS [Online] BIOSCIENCES • Oddos, Thierry INFORMATION SERVICE, PHILADELPHIA, PA, 92190 Meudon (FR) US; 1993 BARASBY RWJETAL:"Feverfew and • Gendimenico, Gerard J. vascular smooth muscle: Extracts from fresh Neshanic Station, NJ 08853 (US) and dried plants show opposing • Martin, Katharine pharmacological profiles, dependent upon Ringoes, NJ 08551 (US) sesquiterpene lactone content." Database accession no.
    [Show full text]
  • Polypodium Vulgare L.: Polyphenolic Profile, Cytotoxicity and Cytoprotective Properties in Different Cell Lines
    Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 14 May 2021 doi:10.20944/preprints202105.0351.v1 Article Polypodium vulgare L.: polyphenolic profile, cytotoxicity and cytoprotective properties in different cell lines Adrià Farràs1,2, Víctor López2,4, Filippo Maggi3, Giovani Caprioli3, M.P. Vinardell1, Montserrat Mitjans1* 1Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, 08028 Barcelona, Spain; [email protected] (A.F.); [email protected] (P.V.); [email protected] (M.M.) 2Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, Villanueva de Gállego, Zaragoza, 50830 Spain; [email protected] (A.F.); [email protected] (V.L.) 3School of Pharmacy, Università di Camerino, 62032 Camerino, Italy; [email protected] (F.M.); [email protected] (G.C.) 4Instituto Agroalimentario de Aragón-IA2, CITA-Universidad de Zaragoza, 50013 Zaragoza, Spain *Correspondence: [email protected] Abstract: Pteridophytes, represented by ferns and allies, are an important phytogenetic bridge between lower and higher plants (gymnosperms and angiosperms). Ferns have evolved independently of any other species in the plant kingdom being its secondary metabolism a reservoir of phytoconstituents characteristic of this taxon. The study of the possible medicinal uses of Polypodium vulgare L. (Polypodiaceae), PV, has increased particularly when in 2008 the European Medicines Agency published a monograph about the rhizome of this species. Thus, our objective is to provide scientific knowledge on the methanolic extract from the fronds of P. vulgare L., one of the main ferns described in the Prades Mountains, to contribute to the validation of certain traditional uses. Specifically, we have characterized the methanolic extract of PV fronds (PVM) by HPLC-DAD and investigated its potential cytotoxicity, phototoxicity, ROS production and protective effects against oxidative stress by using in vitro methods.
    [Show full text]
  • Antioxidant Evaluation-Guided Chemical Profiling and Structure
    www.nature.com/scientificreports OPEN Antioxidant evaluation-guided chemical profling and structure- activity analysis of leaf extracts from fve trees in Broussonetia and Morus (Moraceae) Xinxin Cao1, Lingguang Yang1, Qiang Xue1, Fan Yao1, Jing Sun1, Fuyu Yang2 & Yujun Liu 1* Morus and Broussonetia trees are widely used as food and/or feed. Among 23 phenolics identifed from leaves of fve Moraceae species using UPLC–QTOF–MS/MS, 15 were screened using DPPH/ABTS- guided HPLCs, including seven weak (favonoids with one hydroxyl on B-ring) and eight strong (four cafeoylquinic acids and four favonoids, each with a double hydroxyl on B-ring) antioxidants. We then determined the activity and synergistic efects of individual antioxidants and a mixture of the eight strongest antioxidants using DPPH-guided HPLC. Our fndings revealed that (1) favonoid glucuronide may have a more negative efect on antioxidant activity than glucoside, and (2) other compounds in the mixture may exert a negative synergistic efect on antioxidant activity of the four favonoids with B-ring double hydroxyls but not the four cafeoylquinic acids. In conclusion, the eight phenolics with the strongest antioxidant ability reliably represented the bioactivity of the fve extracts examined in this study. Moreover, the Morus alba hybrid had more phenolic biosynthesis machinery than its cross-parent M. alba, whereas the Broussonetia papyrifera hybrid had signifcantly less phenolic machinery than B. papyrifera. This diference is probably the main reason for livestock preference for the hybrid of B. papyrifera over B. papyrifera in feed. Morus and Broussonetia tree species (family: Moraceae) have high economic value; among other uses, their leaves are widely used as feed to improve meat quality.
    [Show full text]
  • Indiana Medical History Museum Guide to the Medicinal Plant Garden
    Indiana Medical History Museum Guide to the Medicinal Plant Garden Garden created and maintained by Purdue Master Gardeners of Marion County IMHM Medicinal Plant Garden Plant List – Common Names Trees and Shrubs: Arborvitae, Thuja occidentalis Culver’s root, Veronicastrum virginicum Black haw, Viburnum prunifolium Day lily, Hemerocallis species Catalpa, Catalpa bignonioides Dill, Anethum graveolens Chaste tree, Vitex agnus-castus Elderberry, Sambucus nigra Dogwood, Cornus florida Elecampane, Inula helenium Elderberry, Sambucus nigra European meadowsweet, Queen of the meadow, Ginkgo, Ginkgo biloba Filipendula ulmaria Hawthorn, Crateagus oxycantha Evening primrose, Oenothera biennis Juniper, Juniperus communis False Solomon’s seal, Smilacina racemosa Redbud, Cercis canadensis Fennel, Foeniculum vulgare Sassafras, Sassafras albidum Feverfew, Tanacetum parthenium Spicebush, Lindera benzoin Flax, Linum usitatissimum Witch hazel, Hamamelis virginiana Foxglove, Digitalis species Garlic, Allium sativum Climbing Vines: Golden ragwort, Senecio aureus Grape, Vitis vinifera Goldenrod, Solidago species Hops, Humulus lupulus Horehound, Marrubium vulgare Passion flower, Maypop, Passiflora incarnata Hyssop, Hyssopus officinalis Wild yam, Dioscorea villosa Joe Pye weed, Eupatorium purpureum Ladybells, Adenophora species Herbaceous Plants: Lady’s mantle, Alchemilla vulgaris Alfalfa, Medicago sativa Lavender, Lavendula angustifolia Aloe vera, Aloe barbadensis Lemon balm, Melissa officinalis American skullcap, Scutellaria laterifolia Licorice, Glycyrrhiza
    [Show full text]
  • Identification of Dietary Phytochemicals Capable Of
    antioxidants Article Identification of Dietary Phytochemicals Capable of Enhancing the Autophagy Flux in HeLa and Caco-2 Human Cell Lines 1, 2, 1, 1 1 Kohta Ohnishi *, Satoshi Yano y, Moe Fujimoto y, Maiko Sakai , Erika Harumoto , Airi Furuichi 1, Masashi Masuda 1 , Hirokazu Ohminami 1, Hisami Yamanaka-Okumura 1 , Taichi Hara 2,* and Yutaka Taketani 1,* 1 Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan; [email protected] (M.F.); [email protected] (M.S.); [email protected] (E.H.); [email protected] (A.F.); [email protected] (M.M.); [email protected] (H.O.); [email protected] (H.Y.-O.) 2 Laboratory of Food and Life Science, Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Japan; [email protected] * Correspondence: [email protected] (K.O.); [email protected] (T.H.); [email protected] (Y.T.); Tel.: +81-88-633-9595 (K.O. & Y.T.); +81-4-2947-6763 (T.H.) These authors contributed equally to this work. y Received: 19 October 2020; Accepted: 25 November 2020; Published: 27 November 2020 Abstract: Autophagy is a major degradation system for intracellular macromolecules. Its decline with age or obesity is related to the onset and development of various intractable diseases. Although dietary phytochemicals are expected to enhance autophagy for preventive medicine, few studies have addressed their effects on the autophagy flux, which is the focus of the current study.
    [Show full text]
  • Taking Herbal Medications Before Surgery
    Taking Herbal Medications before Surgery The American Society of Anaesthesiologists (ASA) is cautioning those who use herbal medications to stop taking these “natural” products 1 week prior to having a surgery. Recent findings disclose that seven out of 10 herbal medicine users never tell their physicians about the herbal products they are taking. Most believe that since the products are “natural” they must be safe. Just because a medicine is called “natural” or “herbal” does not mean it is harmless or completely safe. Many of these products are quite potent and can be dangerous, especially if the patient’s anaesthetist or surgeon does not know that the patient is taking them. A number of anaesthetists have reported significant changes in heart rate or blood pressure in some patients who have been taking herbal medications. These herbal products include: Baikal skullcap root (Scutellaria baicalensis) Herb or dietary supplement Bilberry fruit (Vaccinium myrtillus) Ginkgo leaves (Ginkgo biloba) Black currant seed oil (Ribes nigrum) Ginseng root (Panax ginseng) Bladderwrack (Fucus vesiculosus) Green tea (Camellia sinensis) Borage seed oil (Borago officinalis) Hawthorn leaf and flower (Crataegus oxyacantha, Crataegus monogyna) Bromelain from pineapple fruit and stem (Ananas comosus) Horse chestnut bark (Aesculus hippocastanum) Cayenne fruit (Capsicum frutescens) Huang qi (Astragalus membranaceus) Celery plant (Apium graveolens) Kava kava root (Piper methysticum) Chamomile, German flowers (Matricaria recutita) Licorice root (Glycyrrhiza glabra) Clove oil (Syzygium aromaticum) Omega 3 Coleus roots (Coleus forskohlii) Papain from papaya leaves and unripe fruit (Carica papaya) Da huang, Chinese rhubarb root (Rheum palmatum) Pau d’arco bark (Tabebuia avellanedae) Dan shen root (Salvia miltiorrhiza) Reishi mushrooms (Ganoderma lucidum) Dandelion root (Taraxacum officinale) St.
    [Show full text]
  • CLXX VIIL- the Methylation of Quercetin
    View Article Online / Journal Homepage / Table of Contents for this issue 1632 PEREIN : THE METHYLATION OF QUERCETIN. CLXX VIIL- The Methylation of Quercetin. Published on 01 January 1913. Downloaded by Nanyang Technological University 25/08/2015 11:37:09. By ARTHURGEORGE PERKIN. WHEREASin 1884 Herzig (Monntsh., 5, 72) observed that quercetin could not be completely methylated by means of methyl iodide and alkali, v. Kostanecki and Dreher, as the result of their experiments with the monohydroxyxanthones (Rer., 1893, 26, 76), showed that although the methyl ethers of the 2-, 3-, and 4-compounds could be readily prepared by this method, the 1-hydroxyxanthone in which the hydroxyl is adjacent to the carbonyl group was thus not affected. In relation also to the dihydroxyxanthone, chrysin, Kostanecki states (Bey., 1893, 26, 2901), “Dass im Chrysin beim methyliren ein Hydroxyl unangeriffen bleibt . das Hydroxyl welches im Orthostellung steht, sich nicht methyliren lasst.” Alizarin (Schunck and Marchlewski, T., 1894, 65, 185) behaves similarly, and, indeed, this property has been so generally observed in the case of aromatic hydroxy-ketones and acids that the resist- View Article Online PERKIN : TEE METHY LATION OF QUERCETIN. 1633 ance of an hydroxyl group to methylation by this process has in many cases been considered to serve for the detection of a carbonyl group. Although ethyl iodide resembles methyl iodide in this respect, and it appears to have been generally considered that the complete ethylation of such hydroxy-compounds could not be effected by means of this reagent, certain exceptions in this case are to be found in the literature, notably as regards resaceto- phenone (Gregor, Mo?~nfsh.,1894, 15, 437, and Wechsler, ibid., p.
    [Show full text]
  • Pollens - Weeds and Garden Plants, Alfalfa Medicago Sativa
    Product: 1057 - Pollens - Weeds and Garden Plants, Alfalfa Medicago sativa Manufacturers of this Product Antigen Laboratories, Inc. - Liberty, MO (Lic. No. 468, STN No. 102223) Hollister-Stier Labs, LLC - Spokane, WA (Lic. No. 1272, STN No. 103888) ALK-Abello Inc. - Port Washington, NY (Lic. No. 1256, STN No. 103753) Nelco Laboratories, Inc. - Deer Park, NY (Lic. No. 459, STN No. 102192) Search Strategy PubMed: alfalfa allergen; allfalfa allergy; alfalfa immunotherapy; Medicago sativa allergy; Medicago sativa allergen; Medicago sativa immunotherapy; Alfalfa pollen Google: alfalfa allergy; alfalfa allergy adverse; alfalfa allergen; alfalfa allergen adverse; same search results performed for Medicago sativa Nomenclature According to ITIS, the scientific name is Medicago sativa (TSN 183623). The common name is alfalfa. The scientific and common names are correct and current. There are two subspecies listed: M. sativa ssp. falcate and sativa. The Medicago genus is found in the Fabaceae family. Parent Product 1057 - Pollens - Weeds and Garden Plants, Alfalfa Medicago sativa Published Data PMID: 9109711: One article described skin prick testing with inhalent allergens, including Alfalfa, Medicago sativa from "Hollister-Stier, (now Miles, Inc., Connecticut, USA)" on a Saudi Arabian population, including North American expatriots. PMID: 6733890: Positive skin test results were recorded for M. sativa (13.5%) in this Mediterranean study of pollen counts and pollinosis. Documents PubMed Number Author Year Published 563_ Ann Allergy Asthma Immunol-78-415.pdf 9109711 Suliaman, F.A. 1997 1090_ ClinicalAllergy14-249-258.pdf 6733890 Bousquet, J. 1984 Panels: Original Panel Recommendation Reclassification Panel Recommendation Diagnosis: none none Therapy: none none Page 1 of 218 9/9/2011 Product: 1058 - Pollens - Weeds and Garden Plants, Allscale Atriplex polycarpa Recommended Common Name Saltbush, Desert Manufacturers of this Product Antigen Laboratories, Inc.
    [Show full text]