Metabolic and Biochemical Profiling of Phenolic Compound and Their Biosynthesis in Oil Crops
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Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models
molecules Review Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review Maria Elaine Araruna 1, Catarina Serafim 1, Edvaldo Alves Júnior 1, Clelia Hiruma-Lima 2, Margareth Diniz 1,3 and Leônia Batista 1,3,* 1 Postgraduate Program in Natural Products and Bioactive Synthetic, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil; [email protected] (M.E.A.); [email protected] (C.S.); [email protected] (E.A.J.); [email protected] (M.D.) 2 Department of Structural and Functional Biology (Physiology), Institute of Biosciences, São Paulo State University, Botucatu 18618-970, SP, Brazil; [email protected] 3 Department of Pharmacy, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil * Correspondence: [email protected]; Tel.: +55-83-32167003; Fax: +55-83-32167502 Academic Editors: Maurizio Battino, Jesus Simal-Gandara and Esra Capanoglu Received: 8 September 2020; Accepted: 28 September 2020; Published: 20 November 2020 Abstract: Inflammatory bowel diseases (IBDs) refer to a group of disorders characterized by inflammation in the mucosa of the gastrointestinal tract, which mainly comprises Crohn’s disease (CD) and ulcerative colitis (UC). IBDs are characterized by inflammation of the intestinal mucosa, are highly debilitating, and are without a definitive cure. Their pathogenesis has not yet been fully elucidated; however, it is assumed that genetic, immunological, and environmental factors are involved. People affected by IBDs have relapses, and therapeutic regimens are not always able to keep symptoms in remission over the long term. Natural products emerge as an alternative for the development of new drugs; bioactive compounds are promising in the treatment of several disorders, among them those that affect the gastrointestinal tract, due to their wide structural diversity and biological activities. -
L.) Leaves Tao Jiang1,3, Kunyuan Guo2,3, Lingdi Liu1, Wei Tian1, Xiaoliang Xie1, Saiqun Wen1 & Chunxiu Wen1*
www.nature.com/scientificreports OPEN Integrated transcriptomic and metabolomic data reveal the favonoid biosynthesis metabolic pathway in Perilla frutescens (L.) leaves Tao Jiang1,3, Kunyuan Guo2,3, Lingdi Liu1, Wei Tian1, Xiaoliang Xie1, Saiqun Wen1 & Chunxiu Wen1* Perilla frutescens (L.) is an important medicinal and edible plant in China with nutritional and medical uses. The extract from leaves of Perilla frutescens contains favonoids and volatile oils, which are mainly used in traditional Chinese medicine. In this study, we analyzed the transcriptomic and metabolomic data of the leaves of two Perilla frutescens varieties: JIZI 1 and JIZI 2. A total of 9277 diferentially expressed genes and 223 favonoid metabolites were identifed in these varieties. Chrysoeriol, apigenin, malvidin, cyanidin, kaempferol, and their derivatives were abundant in the leaves of Perilla frutescens, which were more than 70% of total favonoid contents. A total of 77 unigenes encoding 15 enzymes were identifed as candidate genes involved in favonoid biosynthesis in the leaves of Perilla frutescens. High expression of the CHS gene enhances the accumulation of favonoids in the leaves of Perilla frutescens. Our results provide valuable information on the favonoid metabolites and candidate genes involved in the favonoid biosynthesis pathways in the leaves of Perilla frutescens. Perilla frutescens (L.), which is a self-compatible annual herb, belongs to the family Lamiaceae. Tis species has been widely cultivated in China, Japan, and Korea for centuries. Perilla frutescens is an important medicinal and edible plant in China with medical and nutritional uses 1. Its leaves can be utilized as a transitional medicinal herb, as a vegetable, and as a spice, and its seeds can be processed into foods and nutritional edible oils 2. -
Global Transcriptome Analysis and Identification of Genes Involved In
www.nature.com/scientificreports OPEN Global transcriptome analysis and identification of genes involved in nutrients accumulation during Received: 19 December 2016 Accepted: 31 August 2017 seed development of rice tartary Published: xx xx xxxx buckwheat (Fagopyrum Tararicum) Juan Huang1, Jiao Deng1, Taoxiong Shi1, Qijiao Chen1, Chenggang Liang1, Ziye Meng1, Liwei Zhu1, Yan Wang1, Fengli Zhao2, Shizhou Yu3 & Qingfu Chen1 Tartary buckwheat seeds are rich in various nutrients, such as storage proteins, starch, and flavonoids. To get a good knowledge of the transcriptome dynamics and gene regulatory mechanism during the process of seed development and nutrients accumulation, we performed a comprehensive global transcriptome analysis using rice tartary buckwheat seeds at different development stages, namely pre-filling stage, filling stage, and mature stage. 24 819 expressed genes, including 108 specifically expressed genes, and 11 676 differentially expressed genes (DEGs) were identified. qRT-PCR analysis was performed on 34 DEGs to validate the transcriptome data, and a good consistence was obtained. Based on their expression patterns, the identified DEGs were classified to eight clusters, and the enriched GO items in each cluster were analyzed. In addition, 633 DEGs related to plant hormones were identified. Furthermore, genes in the biosynthesis pathway of nutrients accumulation were analyzed, including 10, 20, and 23 DEGs corresponding to the biosynthesis of seed storage proteins, flavonoids, and starch, respectively. This is the first transcriptome analysis during seed development of tartary buckwheat. It would provide us a comprehensive understanding of the complex transcriptome dynamics during seed development and gene regulatory mechanism of nutrients accumulation. Seed is the primary storage organ in plants for storing nutrients such as starch, lipids, and proteins1. -
Comparison of Metabolome and Transcriptome of Flavonoid
International Journal of Molecular Sciences Article Comparison of Metabolome and Transcriptome of Flavonoid Biosynthesis Pathway in a Purple-Leaf Tea Germplasm Jinmingzao and a Green-Leaf Tea Germplasm Huangdan reveals Their Relationship with Genetic Mechanisms of Color Formation Xuejin Chen, Pengjie Wang, Yucheng Zheng, Mengya Gu, Xinying Lin, Shuyan Wang, Shan Jin * and Naixing Ye * College of Horticulture, Fujian Agriculture and Forestry University/Key Laboratory of Tea Science in University of Fujian Province, Fuzhou 350002, China; [email protected] (X.C.); [email protected] (P.W.); [email protected] (Y.Z.); [email protected] (M.G.); [email protected] (X.L.); [email protected] (S.W.) * Correspondence: [email protected] (S.J.); [email protected] (N.Y.) Received: 4 May 2020; Accepted: 7 June 2020; Published: 11 June 2020 Abstract: Purple-leaf tea is a phenotype with unique color because of its high anthocyanin content. The special flavor of purple-leaf tea is highly different from that of green-leaf tea, and its main ingredient is also of economic value. To probe the genetic mechanism of the phenotypic characteristics of tea leaf color, we conducted widely targeted metabolic and transcriptomic profiling. The metabolites in the flavonoid biosynthetic pathway of purple- and green-leaf tea were compared, and results showed that phenolic compounds, including phenolic acids, flavonoids, and tannins, accumulated in purple-leaf tea. The high expression of genes related to flavonoid biosynthesis (e.g., PAL and LAR) exhibits the specific expression of biosynthesis and the accumulation of these metabolites. Our result also shows that two CsUFGTs were positively related to the accumulation of anthocyanin. -
Flavonoids and Isoflavonoids Biosynthesis in the Model
plants Review Flavonoids and Isoflavonoids Biosynthesis in the Model Legume Lotus japonicus; Connections to Nitrogen Metabolism and Photorespiration Margarita García-Calderón 1, Carmen M. Pérez-Delgado 1, Peter Palove-Balang 2, Marco Betti 1 and Antonio J. Márquez 1,* 1 Departamento de Bioquímica Vegetal y Biología Molecular, Facultad de Química, Universidad de Sevilla, Calle Profesor García González, 1, 41012-Sevilla, Spain; [email protected] (M.G.-C.); [email protected] (C.M.P.-D.); [email protected] (M.B.) 2 Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University in Košice, Mánesova 23, SK-04001 Košice, Slovakia; [email protected] * Correspondence: [email protected]; Tel.: +34-954557145 Received: 28 April 2020; Accepted: 18 June 2020; Published: 20 June 2020 Abstract: Phenylpropanoid metabolism represents an important metabolic pathway from which originates a wide number of secondary metabolites derived from phenylalanine or tyrosine, such as flavonoids and isoflavonoids, crucial molecules in plants implicated in a large number of biological processes. Therefore, various types of interconnection exist between different aspects of nitrogen metabolism and the biosynthesis of these compounds. For legumes, flavonoids and isoflavonoids are postulated to play pivotal roles in adaptation to their biological environments, both as defensive compounds (phytoalexins) and as chemical signals in symbiotic nitrogen fixation with rhizobia. In this paper, we summarize the recent progress made in the characterization of flavonoid and isoflavonoid biosynthetic pathways in the model legume Lotus japonicus (Regel) Larsen under different abiotic stress situations, such as drought, the impairment of photorespiration and UV-B irradiation. Emphasis is placed on results obtained using photorespiratory mutants deficient in glutamine synthetase. -
Bilirubin: an Animal Pigment in the Zingiberales and Diverse Angiosperm Orders Cary L
Florida International University FIU Digital Commons FIU Electronic Theses and Dissertations University Graduate School 11-5-2010 Bilirubin: an Animal Pigment in the Zingiberales and Diverse Angiosperm Orders Cary L. Pirone Florida International University, [email protected] DOI: 10.25148/etd.FI10122201 Follow this and additional works at: https://digitalcommons.fiu.edu/etd Part of the Biochemistry Commons, and the Botany Commons Recommended Citation Pirone, Cary L., "Bilirubin: an Animal Pigment in the Zingiberales and Diverse Angiosperm Orders" (2010). FIU Electronic Theses and Dissertations. 336. https://digitalcommons.fiu.edu/etd/336 This work is brought to you for free and open access by the University Graduate School at FIU Digital Commons. It has been accepted for inclusion in FIU Electronic Theses and Dissertations by an authorized administrator of FIU Digital Commons. For more information, please contact [email protected]. FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida BILIRUBIN: AN ANIMAL PIGMENT IN THE ZINGIBERALES AND DIVERSE ANGIOSPERM ORDERS A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in BIOLOGY by Cary Lunsford Pirone 2010 To: Dean Kenneth G. Furton College of Arts and Sciences This dissertation, written by Cary Lunsford Pirone, and entitled Bilirubin: An Animal Pigment in the Zingiberales and Diverse Angiosperm Orders, having been approved in respect to style and intellectual content, is referred to you for judgment. We have read this dissertation and recommend that it be approved. ______________________________________ Bradley C. Bennett ______________________________________ Timothy M. Collins ______________________________________ Maureen A. Donnelly ______________________________________ John. T. Landrum ______________________________________ J. Martin Quirke ______________________________________ David W. Lee, Major Professor Date of Defense: November 5, 2010 The dissertation of Cary Lunsford Pirone is approved. -
Noncatalytic Chalcone Isomerase-Fold Proteins in Humulus Lupulus Are Auxiliary Components in Prenylated Flavonoid Biosynthesis
Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis Zhaonan Bana,b, Hao Qina, Andrew J. Mitchellc, Baoxiu Liua, Fengxia Zhanga, Jing-Ke Wengc,d, Richard A. Dixone,f,1, and Guodong Wanga,1 aState Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China; bUniversity of Chinese Academy of Sciences, 100049 Beijing, China; cWhitehead Institute for Biomedical Research, Cambridge, MA 02142; dDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; eBioDiscovery Institute, University of North Texas, Denton, TX 76203; and fDepartment of Biological Sciences, University of North Texas, Denton, TX 76203 Contributed by Richard A. Dixon, April 25, 2018 (sent for review February 6, 2018; reviewed by Joerg Bohlmann and Mattheos A. G. Koffas) Xanthohumol (XN) and demethylxanthohumol (DMX) are special- braries have been deposited in the TrichOME database [www. ized prenylated chalconoids with multiple pharmaceutical appli- planttrichome.org (18)], and numerous large RNAseq datasets from cations that accumulate to high levels in the glandular trichomes different hop tissues or cultivars have also been made publically of hops (Humulus lupulus L.). Although all structural enzymes in available. By mining the hops transcriptome data, we and others have the XN pathway have been functionally identified, biochemical functionally identified several key terpenophenolic biosynthetic en- mechanisms underlying highly efficient production of XN have zymes from hop glandular trichomes (1, 18–23); these include car- not been fully resolved. In this study, we characterized two non- boxyl CoA ligase (CCL) genes and two aromatic prenyltransferase catalytic chalcone isomerase (CHI)-like proteins (designated as (PT) genes (HlPT1L and HlPT2) (22, 23). -
Naturally Occurring Anthocyanin, Structure, Functions And
iochemis t B try n & la P P h f y o s l i Journal of o a l n o r g Pervaiz et al., J Plant Biochem Physiol 2017, 5:2 u y o J DOI: 10.4172/2329-9029.1000187 ISSN: 2329-9029 Plant Biochemistry & Physiology Review Article Open Access Naturally Occurring Anthocyanin, Structure, Functions and Biosynthetic Pathway in Fruit Plants Tariq Pervaiz1,2, Jiu Songtao1, Faezeh Faghihi3, Muhammad Salman Haider1 and Jinggui Fang1* 1Key Laboratory of Genetics and Fruit Development, College of Horticulture, Nanjing Agricultural University, Nanjing 210095, PR China 2Department of Agriculture and Food Technology, Karakoram International University Gilgit, Pakistan 3Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran *Corresponding author: Jinggui Fang, Key Laboratory of Genetics and Fruit Development, College of Horticulture, Nanjing Agricultural University, Nanjing, PR China, E-mail: [email protected] Received Date: April 25, 2017; Accepted Date: April 29, 2017; Published Date: May 06, 2017 Copyright: © 2017 Pervaiz T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Anthocyanins are naturally occurring compounds, member of the flavonoid groups of photochemical, involved in defense against the damaging effects of UV irradiation in plants and protect from many oxidants. The anthocyanins, group of pigments are relatively small and diverse flavonoid family in nature, and responsible for the attractive colors, red and purple to blue in many plants. Presence of pigments in flowers and fruits seems to provide attraction for pollination and aiding seed distribution, it also provides antiviral and antimicrobial activities, however their occurrence in the vacuoles remains ambiguous. -
Nutritional and Medicinal Properties of Solanaceous Vegetables Shilpa Devi and Arvind Nagar Division of Vegetable Science, IARI, New Delhi, 110012
Shilpa Devi and Arvind Nagar Your full article ( between 500 to 5000 words) - - Do check for grammatical errors or spelling mistakes Nutritional and Medicinal Properties of Solanaceous Vegetables Shilpa Devi and Arvind Nagar Division of vegetable Science, IARI, New Delhi, 110012 Corresponding mail- [email protected] Introduction The family Solanaceae, or nightshades, is an economically important family of flowering plants. The family ranges from annual and perennial herbs to vines, or either shrubs, and trees, including a number of important vegetable crops like tomato, pepper, eggplant, white and red potato, and tomatillo. This family also contains several plants that are considered toxic to humans being such as the weeds jimsonweed, nightshade and mandrake. Many members of the family contain potent alkaloids that are having immense value by considering its nutritional value. The family belongs to the order Solanales, in the asterid group dicotyledons (Magnoliopsida). The solanaceae consists of approximately 98 genera and about 2,700 species, with a great diversity in their habitats, morphology and ecology. Worldwide 53% of children are malnourished and underweight with 40% of them living in India. Solanaceous vegetable crops are important source of vitamin C, A, E, thiamine, niacin, pyridoxine, folacin, minerals and dietry fibres which play a significant role in human nutrition and helps to cope with malnutrition. Nutritional and Medicinal Properties of Tomato Tomatoes are the 2nd highly produced and consumed vegetable in the world today. Tomato is consumed either fresh or in many processed forms like ketchup, canned whole or in pieces, puree, sauce, soup, juice, or sun- dried. Tomato fruits are considered a low energy dense food with unique constituents that may positively affect health. -
Plant Fibers and Phenolics: a Review on Their Synthesis, Analysis and Combined Use for Biomaterials with New Properties
fibers Review Plant Fibers and Phenolics: A Review on Their Synthesis, Analysis and Combined Use for Biomaterials with New Properties Roberto Berni 1,2 , Giampiero Cai 1 , Jean-Francois Hausman 3 and Gea Guerriero 3,* 1 Department of Life Sciences, University of Siena, Via P.A. Mattioli 4, I-53100 Siena, Italy 2 Trees and Timber Institute-National Research Council of Italy (CNR-IVALSA), Via Aurelia 49, I-58022 Follonica (GR), Italy 3 Environmental Research and Innovation Department, Luxembourg Institute of Science and Technology, 5, Avenue des Hauts-Fourneaux, L-4362 Esch/Alzette, Luxembourg * Correspondence: [email protected]; Tel.: +352-275-888-5023 Received: 13 June 2019; Accepted: 26 August 2019; Published: 31 August 2019 Abstract: Devising environmental-friendly processes in biotechnology is a priority in the current economic scenario. Weare witnessing a constant and steady push towards finding sustainable solutions to societal challenges by promoting innovation-driven activities minimizing the environmental impact and valorizing natural resources. In bioeconomy, plants are among the most important renewable sources of both fibers (woody and cellulosic) and phytochemicals, which find applications in many industrial sectors, spanning from the textile, to the biocomposite, medical, nutraceutical, and pharma sectors. Given the key role of plants as natural sources of (macro)molecules, we here provide a compendium on the use of plant fibers functionalized/impregnated with phytochemicals (in particular phenolic extracts). The goal is to review the various applications of natural fibers functionalized with plant phenolics and to valorize those plants that are source of both fibers and phytochemicals. Keywords: plant fibers; cellulose; secondary metabolism; phenolics 1. -
Expression and Functional Analysis of the Nobiletin Biosynthesis-Related
www.nature.com/scientificreports OPEN Expression and functional analysis of the nobiletin biosynthesis‑related gene CitOMT in citrus fruit Mao Seoka1,4, Gang Ma1,2,4, Lancui Zhang2, Masaki Yahata1,2, Kazuki Yamawaki1,2, Toshiyuki Kan3 & Masaya Kato1,2* Nobiletin, a polymethoxy favone (PMF), is specifc to citrus and has been reported to exhibit important health-supporting properties. Nobiletin has six methoxy groups at the 3′,4′,5,6,7,8-positions, which are catalyzed by O-methyltransferases (OMTs). To date, researches on OMTs in citrus fruit are still limited. In the present study, a novel OMT gene (CitOMT) was isolated from two citrus varieties Satsuma mandarin (Citrus unshiu Marc.) and Ponkan mandarin (Citrus reticulata Blanco), and its function was characterized in vitro. The results showed that the expression of CitOMT in the favedo of Ponkan mandarin was much higher than that of Satsuma mandarin during maturation, which was consistent with the higher accumulation of nobiletin in Ponkan mandarin. In addition, functional analysis showed that the recombinant protein of CitOMT had methylation activity to transfer a methyl group to 3′-hydroxy group of favones in vitro. Because methylation at the 3′-position of favones is vital for the nobiletin biosynthesis, CitOMT may be a key gene responsible for nobiletin biosynthesis in citrus fruit. The results presented in this study will provide new strategies to enhance nobiletin accumulation and improve the nutritional qualities of citrus fruit. Flavonoids are a group of secondary metabolites that include more than 10,000 kinds of derivatives1. According to their structure, favonoids are divided into several subgroups, including favanones, favones, favonols, favanols, isofavones, and anthocyanidins2. -
Effect of Prebiotic Supplementation on Performance and Health of Dairy Calves: Protocol for a Systematic Review and Meta-Analysis R
Effect of prebiotic supplementation on performance and health of dairy calves: protocol for a systematic review and meta-analysis R. B. Lopes1, E. D. Fausak1, C. Bernal-Córdoba1, N. Silva-del-Río1* 1University of California Davis, US; [email protected] (RBL); [email protected] (EDF); [email protected] (CBC); [email protected] (NSDR) *Corresponding author: Veterinary Medicine Teaching and Research Center, University of California Davis, 18830 Road 112, Tulare, CA, 93274, Phone: 559-688-1731, Fax: 559-686- 4231. Author Contributions: RBL: Assist to develop search strategy and literature search, data screening, extraction, statistical analysis, and protocol and manuscript preparation. EDF: Develop search strategy and literature search, edit protocol. CBC: Data screening, review data extraction, review protocol and manuscript. NSDR: Assist, edit and review protocol and manuscript. Amendments: Any amendments to this protocol will be documented and justified in the final review. Support: This study is financially supported by the California Department of Food and Agriculture (CDFA) and it is part of the Antimicrobial Use and Stewardship (AUS) program. INTRODUCTION Rationale In the dairy industry, the treatment of sick calves is commonly based on the antibiotic use by systematic therapy or addition into the milk (Foutz et al., 2018; Urie et al., 2018). The overuse and misuse of antibiotics contribute to the development of antimicrobial resistance, which is a threat to both animal and human health. Thus, it is fundamental to investigate preventative strategies, such as prebiotics, to reduce the incidence of diseases and consequently the use of antibiotics. According to the International Scientific Association for Probiotics and Prebiotics, prebiotic is a “substrate that is selectively utilized by host microorganisms conferring a health benefit” (Gibson et al., 2017).