January/February 2001 Lawrence Livermore National Laboratory

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January/February 2001 Lawrence Livermore National Laboratory January/ February 2001 U.S. Department of Energy’s Lawrence Livermore National Laboratory About the Cover This issue of S&TR pays tribute to Roger Batzel, the Laboratory’s sixth and longest- tenured director (1971–1988). Batzel died on July 29, 2000, at the age of 78. He was an extraordinary leader, deeply respected personally and for the significant growth and achievement he fostered in Laboratory missions. The issue features an overview of Batzel’s long and distinguished career at Livermore (1953–2000). It also focuses on the particular achievements of his directorship. Among them are the growth of a strong biomedical capability, innovations in alternative energy sources, and significant progress in the science that supports deterrence and nonproliferation of nuclear weapons and contributed to the end of the Cold War. Cover design: George Kitrinos About the Review Lawrence Livermore National Laboratory is operated by the University of California for the Department of Energy. At Livermore, we focus science and technology on assuring our nation’s security. We also apply that expertise to solve other important national problems in energy, bioscience, and the environment. Science & Technology Review is published 10 times a year to communicate, to a broad audience, the Laboratory’s scientific and technological accomplishments in fulfilling its primary missions. The publication’s goal is to help readers understand these accomplishments and appreciate their value to the individual citizen, the nation, and the world. Please address any correspondence (including name and address changes) to S&TR, Mail Stop L-664, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551, or telephone (925) 423-3432. Our e-mail address is [email protected]. S&TR is available on the World Wide Web at www.llnl.gov/str/. © 2001. The Regents of the University of California. All rights reserved. This document has been authored by the Regents of the University of California under contract No. W-7405-Eng-48 with the U.S. Government. To request permission to use any material contained in this document, please submit your request in writing to the Technical Information Department, Document Approval and Report Services, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551, or to our electronic mail address [email protected]. This document was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor the University of California nor any of their employees makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States • • Government or the University of California. The views and opinions of authors expressed herein do not necessarily state Prepared by LLNL under contract or reflect those of the United States Government or the University of California and shall not be used for advertising or No. W-7405-Eng-48 product endorsement purposes. January/February 2001 Lawrence Livermore National Laboratory Contents S&TR Staff Features SCIENTIFIC EDITORS 3 Roger Batzel—A Leader and a Gentleman Jean H. de Pruneda and Commentary by Bruce Tarter Andrew Quong 4 A Career of Distinguished Achievement MANAGING EDITOR Ray Marazzi A superb manager with a quiet and self-effacing demeanor, Roger Batzel presided over a period PUBLICATION EDITOR of unprecedented growth and technical Dean Wheatcraft diversification at Lawrence Livermore. WRITERS Arnie Heller, Ann Parker, Katie Walter, and Dean Wheatcraft ART DIRECTOR AND DESIGNER Research Highlights George Kitrinos 10 From Dosimetry to Genomics INTERNET DESIGNER Roger Batzel’s support of Livermore’s relatively Kitty Tinsley new biomedical research program led to its COMPOSITOR growth into a major contributor to the worldwide Louisa Cardoza Human Genome Project. PROOFREADER 14 Swords into Plowshares and Beyond Carolin Middleton Under Roger Batzel’s leadership, the Laboratory championed numerous long-term, innovative S&TR, a Director’s Office alternative energy technologies to help address publication, is produced by the challenges not unlike those we are facing today. Technical Information Department under the direction of the Office of 18 Adapting to a Changing Weapons Program Policy, Planning, and Special Studies. Roger Batzel’s knowledge of the U.S. weapons program and his much-trusted S&TR is available on the Web professional judgment served the at www.llnl.gov/str/. Laboratory and the nation well as arms control and deterrence emerged as national priorities. Printed in the United States of America Available from Departments National Technical Information Service U.S. Department of Commerce 5285 Port Royal Road 2 The Laboratory in the News Springfield, Virginia 22161 UCRL-52000-01-1/2 21 Patents and Awards Distribution Category UC-0 January/February 2001 2 The Laboratory in the News S&TR January/February 2001 Lab, UC Davis team for cancer research Going fishing in the gene pool The Laboratory and the University of California at Davis Researchers at the Joint Genome Institute (JGI) in Walnut Cancer Center have announced a major collaboration to fight Creek, California, are leading an international effort to map cancer. The institutions have created an integrated cancer the genetic code of the puffer fish. The JGI is a Department research program to accelerate discoveries that help prevent, of Energy collaboration of Lawrence Livermore, Lawrence diagnose, and treat cancer, the nation’s second leading killer. Berkeley, and Los Alamos national laboratories. The affiliation brings together the research and development The puffer fish (known as Fugu in Japan, where it is a strengths of Lawrence Livermore scientists and engineers, delicacy) is an ancient species with 400 million base pairs particularly in biomedical technology and genomics, with of DNA, compared to the 3 billion bases that make up the basic science capabilities of patient-centered clinical human DNA. researchers at the UC Davis center. The puffer fish is being mapped because its genome is At least a dozen projects are under investigation, including: considered simpler and more pure than the human genome, • Studies of plant chemicals that may affect the development which is muddled by genetic “noise” resulting from millions of of cancer. years of evolution. Scientists reason that they can learn much • Studies using ultrasensitive accelerator mass spectroscopy about the fundamental structure of the cluttered human genome to analyze how drugs are absorbed in the body. from the puffer genome. This knowledge will help fill in the • Development of new light diffusion sensors that can detect details of the completed draft of the entire human genome. cancer by measuring how light scatters when it is reflected The same principle that drives the puffer fish research is inside tissue. also leading genetic researchers to investigate the genome of • Development of an ultrashort-pulse laser to use the light other simpler organisms such as the mouse, fruit fly, yeast, scattered off tissue to create images showing melanomas and and nematode. other cancers on the skin. Contact: Elbert Branscomb (925) 296-5700 ([email protected]). Contact: James Felton (925) 422-5656 ([email protected]). Cancer research yields cooking tips Lab technology revises estimate of meteor’s size Researchers at Lawrence Livermore’s Biology and Using an innovative three-dimensional imaging technique, Biotechnology Research Program have found that cooking a team of Laboratory researchers has revised the size estimate hamburgers at specific temperatures and to specific internal of Kleopatra, an unusually elongated metallic asteroid. temperatures and flipping them frequently not only kills In May 2000, researchers at the Jet Propulsion Laboratory harmful bacteria but also reduces the formation of chemicals in Pasadena, California, reported Kleopatra’s length at about that may cause cancer. 217 kilometers. More recently, Livermore’s Mark According to an article by these researchers in the Hammergren and his colleagues used an image-layering November 2000 issue of the Journal of the National Cancer technique called speckle interferometry (S&TR, April 2000, Institute, frying hamburger patties at a pan temperature pp. 17–18) to revise that estimate to about 250 kilometers. of 160°C and turning the patties every minute speeds the Using the 10-meter Keck telescope in Hawaii equipped with cooking process and reduces the formation of harmful, a special high-speed infrared camera, they snapped about potentially cancer-causing compounds. 100 images in a single night of the near-infrared light reflected Before being cooked, the burgers were also inoculated from the asteroid to sample a set of 22 positions in Kleopatra’s with a strain of E. coli bacteria but were found to be rotation. The high-speed imaging technique negates the essentially bacteria-free after being cooked to an internal Earth’s rapidly changing atmospheric effects, which can temperature of 70°C, regardless of pan temperature and distort distant objects in space. frequency of turning. Kleopatra is unusual
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