DOCSLIB.ORG

An In-Vitro Evaluation of the Anthelmintic Activity of Rhizome Extracts of Zingiber Officinalis, Zingiber Zerumbet and Curcuma L

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
An In-Vitro Evaluation of the Anthelmintic Activity of Rhizome Extracts of Zingiber Officinalis, Zingiber Zerumbet and Curcuma L Saroj Kumar Raul et al. / Journal of Pharmacy Research 2012,5(7),3813-3814 Research Article Available online through ISSN: 0974-6943 http://jprsolutions.info An in-vitro evaluation of the anthelmintic activity of rhizome extracts of Zingiber officinalis, Zingiber zerumbet and Curcuma longa, a comparative study *Saroj Kumar Raul, Gopal K Padhy, Jasmin P Charly, K Venkatesh Kumar Maharajah’s College of Pharmacy,Phoolbaugh,Vizianagaram,Andhra Pradesh, India Received on:07-04-2012; Revised on: 12-05-2012; Accepted on:16-06-2012 ABSTRACT The present study was undertaken to evaluate the Anthelmintic activity of ethanol extracts of Zingiber officinalis (Zingiberacae), Zingiber zerumbet (Zingiberacae) and Curcuma longa on Indian earthworm, Pheretima posthuma.Various concentrations (10ug/ml, 25ug/ml, 50ug/ml) of all extracts were tested and results were expressed in terms of time of paralysis and time of death of the earthworm. Piperazine citrate (10ug/ml) was used as reference standard and sterile water as control group. KEYWORDS: Anthelmintic activity, Pheretima posthuma, Piperazine citrate, Zingiber officinalis, Zingiber zerumbet, Curcuma longa INTRODUCTION: Medicinal plants used in India for centuries have an important therapeutic Curcuma longa commonly known as Turmeric is a rhizomatous herbaceous source for treating a variety of ailments and has been found to immense global perennial plant of the ginger family, Zingiberaceae. [2]. It is native to tropical importance. India is perhaps the largest producer of medicinal herbs and is South Asia and needs temperatures between 20 °C and 30 °C and a consider- rightly called the ‘Botanical Garden of the world’. Medicinal herbs have been able amount of annual rainfall to thrive.[3] Plants are gathered annually for used for thousands of years in the indigenous system of medicines like their rhizomes, and propagated from some of those rhizomes in the following Ayurveda, Siddha and Unani. season. Turmeric is currently being investigated for possible benefits in Alzheimer’s disease, [10] cancer, [11][12] arthritis, and other clinical disor- Helmenthiasis is one of the most common infections in mankind affecting a ders.[13][14] As an example of preliminary laboratory research, turmeric large proportion of the world population. Parasitic diseases may cause se- ameliorated the severity of pancreatitis-associated lung injury in mice.[15] vere morbidities including lymphatic filariasis and onchocerciasis. Develop- ment of resistance to most of the commercially available anthelmintics be- Curcuma longa and Zingiber officinale rhizomes are rich for phytoconstituents comes a problem world-wide. viz. alkaloids, saponins, flavonoids, terpenes and steroids. These drugs are widely used in the treatment of different ailments in the Indian system of Zingiber officinale commonly known as ginger lends its name to its genus and medicine. family Zingiberaceae. Ginger produces clusters of white and pink flower buds that bloom into yellow flowers. Because of its aesthetic appeal and the MATERIALS AND METHODS: adaptation of the plant to warm climates, ginger is often used as landscaping The methodology adapted to evaluate the anthelmintic activity of the rhi- around subtropical homes. It is a perennial reed-like plant with annual leafy zomes of Zingiber offficinale, Zingiber zerumbet and Curcuma longs is as stems, about a meter (3 to 4 feet) tall. Traditionally, the root is gathered when follows the stalk withers; it is immediately scalded, or washed and scraped, to kill it and prevent sprouting. Plant materials: The rhizomes of Zingiber officinale, Zingiber zerumbet and Curcuma longa Preliminary research indicates that nine compounds found in ginger may bind were collected from the local market of Vizianagaram, Andhra Pradesh. They to human serotonin receptors, which may explain ginger’s extensive effects were identified and confirmed from the Department of Botany in Maharajah’s on the GI tract and suggesting a mechanism for its effects on anxiety. [7] Autonomous College, Vizianagaram, Andhra Pradesh. Zingiber zerumbet also known as shampoo ginger belongs to the family Collection of worms: Zingiberaceae. It is a vigorous ginger with leafy stems growing to about 1.2 m The Indian earthworm Pheretima posthuma were collected from the water tall. It is found in many tropical countries. The rhizomes of Zingiber zerumbet, logged area of Dharmapuri, Vizianagaram, Andhra Pradesh. They were iden- have been regularly used as food flavoring and appetizer in various cuisines tified from the Department of Zoology, Maharajah’s Autonomous College, while the rhizomes extracts have been used in Malay traditional medicine to Vizianagaram, Andhra Pradesh. treat various types of ailments like inflammatory and pain-mediated dis- eases, worm infestation and diarrhoea.[1] Preparation of extract: The collected materials were washed thoroughly in water, cut into small pieces and air-dried for 3 weeks at 35-40 degree centi- grade. Extraction was done by using Soxhlet apparatus with 90% ethanol as *Corresponding author. solvent. The extracts were concentrated under reduced pressure, dried, pow- dered and stored in an air-tight container. Saroj Kumar Raul, Maharajah’s College of Pharmacy, Preparation of test sample: Phoolbaugh,Vizianagaram, Samples for in-vitro study were prepared by adding Tween 80 as suspend- Andhra Pradesh, India ing agent in 2.5 gram of each extract in 25 milliliters of distilled water to obtain Journal of Pharmacy Research Vol.5 Issue 7.July 2012 3813-3814 Saroj Kumar Raul et al. / Journal of Pharmacy Research 2012,5(7),3813-3814 a stock solution of 100mg/ml. From that stock solution different working ralysis and 16.50 min. for death. While in Zingiber officinale for extract at the dilutions were prepared to get concentrations of 10ug/ml, 25ug/ml and 50ug/ concentration of 10mg/ml, the time of paralysis and death was found to be ml. 13.20 min. and 32.40 min. respectively. At concentration of 20 mg/ml, it was 7.50 min. for paralysis and 24.20 min. for death. For concentration at 50mg/ Anthelmintic activity: ml, the time of paralysis and death was 6.40 min. and 17.5 min. respectively.In The Anthelmintic activity was performed according to the methodology case of combination of both the plant extracts (Curcuma longa and Zingiber followed by Ajayieoba et.al, 2001[6] on adult Indian earthworm, Pheretima officinale), the time of paralysis and death was 10.6 min. and 31.8 min. posthuma due too it’s anatomical and physiological resemblance with human respectively at concentration of 10 mg/ml. At concentration of 20 mg/ml, the intestinal roundworm parasite. Earthworms were divided into 3 groups; time of paralysis and death was 6.8 min. and 27 min. respectively and at 50 consisting of 6 earthworms in each group and were released into 20ml of the mg/ml concentration, the time of paralysis and death was 4.8 min. and 16.3 desired formulation. Group I serve as control and receive only distilled wa- min. respectively. The observations with piperazine citrate showed that ter, Group II serves as standard and receives standard drug Piperazine citrate time of paralysis and death was 7.2 min. and 15.9 min. respectively for (10mg/ml), Group III serves as the alcoholic extract of different concentra- concentration at 20 mg/ml. It was observed that both ginger as well as tur- tions. meric hydro-alcoholic extracts showed a remarkable anthelmintic potential against intestinal parasitism. Amongst the both extracts, Curcuma longa showed Observations were done for the time taken for the paralysis and death of better activity in combination with Zingiber officinale. Anthelmintic activity individual worms. Paralysis was said to be occurred when there no move- of Curcuma longa was enhanced in the presence of Zingiber officinale. ment of any sort could be observed except that the worms were shaking vigorously. Death was said to be occurred when the worms lost their motility REFERENCES: followed with fading of their body color. 1. Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo-Pakistan subcontinent by M S RESULTS AND DISCUSSION: Akhtar, ZafarIqbal, M N Khan, Muhammad Lateef, Small As shown in the Table 1 below the data revealed that Curcuma longa extract Ruminant Research (2000),Volume: 38, Issue: 2, Pages: 99-107 at the concentration of 10 mg/ml showed the time of paralysis and death at 2. Medicinal plants for helminth parasite control: facts and fiction ,S. 12.40 min. and 34 min. respectively. For concentration of 20mg/ml, the Athanasiado, J. Githiori and I. Kyriazakis, Animal (2007), 1:9, pp paralysis and the death time was found to be 7.20 min. and 23.40 min. 1392–1400 respectively. At the concentration of 50mg/ml, time was 5.40 min. for pa- 3. Jain S, Shrivastava S, NayakS and Sumbhate S, Plant Review. Recents trends in Curcuma longa Linn. Phcog. Rev. 2007; 1:119- Table:1 Anthelmintic activity of Extracts 128 4. Ajayieoba EO, Onocha PA, Olarenwaju OT, In-vitro anthelmintic Test Subject Concentration Time taken for Time taken for properties of Buchholziacoriaceae and Gynandropsisgynandra (mg/ml) paralysis(P) in mins death(D) in mins extract. Pharm. Biol. 2001; 39:217-20. Vehicle - - - 5. Identification of serotonin 5-HT1A receptor partial agonists in Piperazine citrate 10 22:40 ±1.5 46.50 ± 2.4 ginger. Nievergelt A. Huonker P. Schoop R. Altmann KH. Gertsch J. Bioorganic & Medicinal Chemistry. 18(9):3345-51, 2010 May 1 6. Iqbal Z, Nadeem QK, Khan MN, Akhtar MS, Waraich FN. In vitro Curcuma longa 10 12.40 ± 1 34 ± 2 25 7.20 ± 1 23.40 ±1.5 anthelmintic activity of Allium sativum, Zingiber officinale, 50 5.40 ± 1 16.50 ± 1 Curcurbita mexicana and Ficusr eligiosa .Int J AgrBiol 2001; 3:454- Zingiber officinale 10 13.20 ± 1 32.40 ± 2 7. 25 7.50 ±1 24.20 ± 1,5 7. T.Ghosh, T.k.Maity, A.Bose and G.K.
Load more

Recommended publications
  • Zingiber Officinale – Ingwer (Zingiberaceae), Heilpflanze Des Jahres 2018 258-263 Jahrb
    ZOBODAT - www.zobodat.at Zoologisch-Botanische Datenbank/Zoological-Botanical Database Digitale Literatur/Digital Literature Zeitschrift/Journal: Jahrbuch des Bochumer Botanischen Vereins Jahr/Year: 2019 Band/Volume: 10 Autor(en)/Author(s): Kabus Iris Artikel/Article: Zingiber officinale – Ingwer (Zingiberaceae), Heilpflanze des Jahres 2018 258-263 Jahrb. Bochumer Bot. Ver. 10 258–263 2019 Zingiber officinale – Ingwer (Zingiberaceae), Heilpflanze des Jahres 2018 IRIS KABUS 1 Einleitung Der Verein zur Förderung der naturgemäßen Heilweise nach THEOPHRASTUS BOMBASTUS VON HOHENHEIM, genannt PARACELSUS (NHV THEOPHRASTUS) kürt seit 2003 die Heilpflanze des Jahres und hat für 2018 Ingwer (Zingiber officinale) aus der Familie der Ingwergewächse (Zingiberaceae) ausgewählt (Abb. 1 & 2). Ingwer erlebte im Laufe der Geschichte immer wieder höchste Beachtung. Vor allem im Mittelalter fehlte die Pflanze auf keiner Tafel, da sie Linderung nach Völlerei und fettem Essen verschaffte und den Reichtum des Gastgebers unterstrich. Eine weitere schon lange bekannte Wirkung ist die Hilfe bei Übelkeit, insbeson- dere Reiseübelkeit und Seekrankheit. Aktuell wird Ingwer in allen Lifestyle-Magazinen als der Schlankmacher schlechthin gepriesen. Abb. 1: Zingiber officinale, „Ingwerknollen“ im Verkauf (A. JAGEL). Abb. 2: Zingiber officinale, Ingwerblüte (Palmengarten Frankfurt, K. KAMM). 2 Name Der deutsche Name Ingwer, das lateinische Zingiber und der englische Ginger leiten sich von der altindischen Bezeichnung srngavera her, wobei das altindische srnga für Horn/Geweih steht und auf die hornförmige Gestalt des Rhizoms hinweist und veru aus dem Tamilischen für Wurzel stammt (MARZELL 1979). Nach GENAUST (1983) ist der erste Wortteil wahrscheinlich eine Abwandlung des Begriffs inchi aus der südindischen Sprache Malayalam und kann mit Wurzel übersetzt werden. Somit würde der Ingwer die wörtliche Bezeichnung „Wurzel-Wurzel“ tragen.
    [Show full text]
  • The Potential for the Biological Control of Hedychium Gardnerianum
    The potential for the biological control of Hedychium gardnerianum Annual report 2012 www.cabi.org KNOWLEDGE FOR LIFE A report of the 4th Phase Research on the Biological Control of Hedychium gardnerianum Produced for Landcare Research, New Zealand and The Nature Conservancy, Hawai’i DH Djeddour, C Pratt, RH Shaw CABI Europe - UK Bakeham Lane Egham Surrey TW20 9TY UK CABI Reference: VM10089a www.cabi.org KNOWLEDGE FOR LIFE In collaboration with The National Bureau of Plant Genetics Resources and The Indian Council for Agricultural Research Table of Contents 1. Executive summary .................................................................................................. 1 2. Recommendations ................................................................................................... 3 3. Acronyms and abbreviations .................................................................................... 4 4. Phase 4 detail .......................................................................................................... 5 4.1 Background ..................................................................................................... 5 4.2 Aims and Milestones ...................................................................................... 5 4.3 Administration .................................................................................................. 7 4.4 Outputs .......................................................................................................... 13 5. Surveys .................................................................................................................
    [Show full text]
  • Zingiber Zerumbet Flower Stem Postharvest Characterization(1)
    CHARLESTON GONÇALVES et al. 127 TECHNICAL ARTICLE Zingiber zerumbet flower stem postharvest characterization(1) CHARLESTON GONÇALVES(2)*, CARLOS EDUARDO FERREIRA DE CASTRO(2), ANA CECILIA RIBEIRO DE CASTRO(3); VIVIAN LOGES(4) ABSTRACT About the Zingiber zerumbet little is known about its cut flower postharvest and market, despite its high ornamental potential. The inflorescences, which resemble a compact cone, emerge from the base of the plants and start with green color changing to red with the age. This study objective was to characterize floral stem of ornamental ginger in two cultivate conditions and to evaluate the longevity of those submitted to post-harvest treatments. Flower stems were harvest from clumps cultivated under full sun and partial shade area, and were submitted to the postharvest treatments: complete flower immersion in tap water (CFI) or only the base stem immersion (BSI). The flower stems harvested from clumps at partial shade presented higher fresh weight, length and diameter of the inflorescences compared to flower stems harvested from clumps at full sun area. The flower stem bracts cultivated in full sun area changed the color from green to red 10.69 and 11.94 days after BSI and CFI postharvest treatments, and the vase life were 22.94 and 28.19 days, respectively. Flower stem harvest in partial shade area change the color only after 18.94 and 18.43 days and the vase life durability was 27.56 and 31.81, respectively. The complete immersion of the flower stem increase the vase life durability in 5.25 and 4.25 days compared to flowers kept with the stem base immersed only, in flower stems harvested from clumps cultivated in full sun area and partial shade area, respectively.
    [Show full text]
  • In Vitro Propagation of Zingiber Spectabile(1)
    270 IN VITRO PROPAGATION OF ZINGIBER SPECTABILE SCIENTIFIC ARTICLE In vitro propagation of Zingiber spectabile (1) MICHELE VALQUÍRIA DOS REIS(2), FERNANDA CARLOTA NERY(3), DÉBORA DE OLIVEIRA PRUDENTE(2), PATRÍCIA DUARTE DE OLIVEIRA PAIVA(4), RENATO PAIVA(2), RODRIGO THEREZAN FREITAS(5), DIOGO PEDROSA CORRÊA DA SILVA(4 ABSTRACT Zingiber spectabile is a tropical ornamental species with difficulties to obtain efficient propagation system. Thus, this study aimed to assess the in vitro propagation of Zingiber spectabile. Seed characterization was determined by measuring length, width and thickness, the weight of 1000 seeds and imbibition curve. In vitro germination of seeds was at constant (25 °C) or alternating temperatures (20-30 ºC). For optimization of in vitro multiplication, different concentrations of activated charcoal (0.0, 0.1 and 0.3%) and sucrose (0.0, 0.1, 0.3, 0.5 and 0.7 M) were evaluated. Plantlets were inoculated in flasks with different sealing systems (PVC covers with or without filters at the center) and culture media (MS or WPM). The plants were acclimatized in Plantmax® substrate. Seeds were of 6.06 mm length, 3.22 mm wide and 2.83 mm thick. The weight of 1,000 seeds corresponded to 46.4 g. The seed imbibition curve approaches to a tree phase pattern. Alternating temperatures induced high germination rates (68%). The addition of 0.3% activated charcoal provided higher root growth and plants with smaller number of senescent leaves. The best plant growth was obtained by the use of 0.1 M sucrose. All acclimatized plants survived (100%). The results demonstrate that Z.
    [Show full text]
  • Ginger, the Genus Zingiber {P. N. Ravindran}
    Ginger The Genus Zingiber Ginger The Genus Zingiber Edited by P.N. Ravindran and K. Nirmal Babu Medicinal and Aromatic Plants — Industrial Profiles CRC PRESS Boca Raton London New York Washington, D.C. Library of Congress Cataloging-in-Publication Data Ginger : the genus Zingiber / edited by P.N. Ravindran, K. Nirmal Babu. p. cm.—(Medicinal and aromatic plants—industrial profiles; v. 41) Includes bibliographical references (p. ). ISBN 0-415-32468-8 (alk. Paper) 1. Ginger. I. Ravindran, P.N. II. Nirmal Babu, K. III. Series. SB304.G56 2004 633.8'3—dc22 2004055370 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher. All rights reserved. Authorization to photocopy items for internal or personal use, or the personal or internal use of specific clients, may be granted by CRC Press, provided that $1.50 per page photocopied is paid directly to Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 USA. The fee code for users of the Transactional Reporting Service is ISBN 0-415-32468-8/05/$0.00+$1.50.
    [Show full text]
  • Aps2013108.Pdf
    npg Section 1: Antitumor Pharmacology 4 10.1038/aps.2013.108 National Cheng Kung University, Tainan 701, Taiwan, China S1.1 Aim: Identification of molecular pathways essential for cancer cells is critical for Anti-cancer activity of Glycosmis parva leaf extract on human colorectal cancer understanding their underlying biology and designing effective cancer therapies. In HT29 cell this study, effect of expression of the aryl hydrocarbon receptor nuclear translocator Nattaporn BURANABUNWONG1, Nijsiri RUANGRUNGSI2, Wacharee LIMPANASITHIKUL3. (ARNT) on the development of acquired drug resistance in cancer cells was 1Interdisciplinary Program of Pharmacology, Graduate School, Chulalongkorn University, investigated. Methods: cisplatin-sensitive or acquired resistant cancer cells were Bangkok, Thailand; 2Collage of Public Health Sciences, Chulalongkorn University, treated with cisplatin for a period of time in ARNT knockdown or overexpression Bangkok,Thailand; 3Department of Pharmacology, Faculty of Medicine, Chulalongkorn conditions. The cell survival and apoptotic markers such as expression of p53, University, Bangkok,Thailand caspase-3 activation and DNA fragmentation were then detected by CCK-8 assay, Aim: Glycosmis parva leaf extract was reported to have cytotoxicity and anti- MTT assay, flow cytometric and Western blot analysis. The effect of ARNT on inflammatory activities with the reduction of COX2 expression in vitro. This MDR1 expression was determined by luciferase reporter analysis, RT-PCR and study aimed to investigate the effect of ethyl acetate extracts from leaves of G Western blot analysis. In addition, the cooperation between Sp1 and ARNT in the parva (GPE) on human colorectal cancer expressing COX2-HT29 cells and its regulation of MDR1 expression was examined by DAPA and luciferase reporter underlying mechanisms of action.
    [Show full text]
  • Ingwer Und Sein Ätherisches Öl“
    DIPLOMARBEIT / DIPLOMA THESIS Titel der Diplomarbeit / Title of the Diploma Thesis „Ingwer und sein ätherisches Öl“ verfasst von / submitted by Dogan Hatice angestrebter akademischer Grad / in partial fulfilment of the requirements for the degree of Magistra der Pharmazie (Mag.pharm.) Wien, 2019 Studienkennzahl lt. Studienblatt / A 449 degree programme code as it appears on the student record sheet: Studienrichtung lt. Studienblatt / Diplomstudium Pharmazie degree programme as it appears on the student record sheet: Betreut von / Supervisor: Univ.-Prof. Mag. pharm. Dr. Gerhard Buchbauer Danksagung Ich bedanke mich ganz herzlich bei Herrn Univ. Prof. Dr. Mag. Gerhard Buchbauer für die Durchführung und die fachliche Beurteilung meiner Arbeit. Besonders möchte ich auch Frau Mag. Dr. Iris Stappen danken für die Betreuung dieser Diplomarbeit und dafür, dass sie jederzeit gut zu erreichen war, wenn ich ein Anliegen oder eine Frage hatte. Und natürlich möchte ich mich auch bedanken bei… meinen Eltern, die mich sowohl vor als auch während des gesamten Studiums unterstützt und immer an mich geglaubt haben. Ich bin sehr glücklich, dass ich eure Tochter bin. meiner Schwester Halime und meinem Bruder Halis, die mich immer ermutigt haben, und immer ein Ohr für mich hatten. Ich bin froh, dass es euch gibt. meinem Ehemann Mehmet, der immer geduldig war, und mich auch dann unterstützt hat, wenn ich vor lauter Prüfungsstress nicht auszuhalten war. meinen Freunden und Studienkollegen, die mich während des Studiums begleitet haben und immer da waren, wenn ich mal Hilfe gebraucht habe. Abstract In der vorliegenden Literaturübersicht wurden verschiedene Studien über Ingwer, sowie die chemische Zusammensetzung des Ingweröls und deren Wirkung und Anwendung ausgearbeitet.
    [Show full text]
  • Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges
    molecules Review Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges Md. Habibur Rahman 1,2,† , Johny Bajgai 1,† , Ailyn Fadriquela 3 , Subham Sharma 1,2, Thuy Thi Trinh 1,2, Rokeya Akter 2, Yun Ju Jeong 1, Seong Hoon Goh 1, Cheol-Su Kim 1 and Kyu-Jae Lee 1,* 1 Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea; [email protected] (M.H.R.); [email protected] (J.B.); [email protected] (S.S.); [email protected] (T.T.T.); [email protected] (Y.J.J.); [email protected] (S.H.G.); [email protected] (C.-S.K.) 2 Department of Global Medical Science, Yonsei University Graduate School, Wonju 26426, Gangwon-do, Korea; [email protected] 3 Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea; [email protected] * Correspondence: [email protected]; Tel: +82-33-741-0331 † These authors contributed equally to the work. Abstract: Natural products derived from plants, as well as their bioactive compounds, have been extensively studied in recent years for their therapeutic potential in a variety of neurodegenerative Citation: Rahman, M.H.; Bajgai, J.; diseases (NDs), including Alzheimer’s (AD), Huntington’s (HD), and Parkinson’s (PD) disease. These Fadriquela, A.; Sharma, S.; Trinh, T.T.; diseases are characterized by progressive dysfunction and loss of neuronal structure and function. Akter, R.; Jeong, Y.J.; Goh, S.H.; Kim, There has been little progress in designing efficient treatments, despite impressive breakthroughs C.-S.; Lee, K.-J.
    [Show full text]
  • Optimisation of Essential Oil Yield and Zerumbone Content in Zingiber
    595 A publication of CHEMICAL ENGINEERING TRANSACTIONS VOL. 63, 2018 The Italian Association of Chemical Engineering Online at www.aidic.it/cet Guest Editors: Jeng Shiun Lim, Wai Shin Ho, Jiří J. Klemeš Copyright © 2018, AIDIC Servizi S.r.l., ISBN 978-88-95608-47-1; ISSN 2283-9216 DOI: 10.3303/CET1863100 Optimisation of Essential Oil Yield and Zerumbone Content in Zingiber Zerumbet Extract Using Hydrodistillation Process a,b a a,b, Noor Amirah Azelan , Ramlan Aziz , Rosnani Hasham * aInstitute of Bioproduct Development, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia bDepartment of Bioprocess and Polymer Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia [email protected] The optimisation of zerumbone content in essential oil of Zingiber zerumbet was investigated using hydrodistillation extraction method. The extractions were carried out to identify the optimum condition of the processing parameters (solvent-to-solid loading ratio, particle size and time) on the essential oil and zerumbone recovery. The extraction variables (solvent-to-solid ratio, particle size and time), on the other hand, were optimi sed by central composite design. The optimum conditions of the Z. zerumbet essential oil extraction were at the solvent-to-solid loading ratio, 187 mL/10 g; particle size, 2,000 µm; and extraction time, 74.28 min, whereas the concentration of Z. zerumbet essential oil and zerumbone as high as 3.73 % and 1.58 % were obtained. Hence, the central composite design model can be used to predict the zerumbone content in essential oil extraction from Z. zerumbet in a hydrodistillation extraction system.
    [Show full text]
  • A Review on Analytical Methods for Antiviral Phytoconstituents
    J Young Pharm, 2021; 13(1) : 7-13. A multifaceted peer reviewed journal in the field of Pharmacy Review Article www.jyoungpharm.org | www.phcog.net A Review on Analytical Methods for Antiviral Phytoconstituents Sivagami B*, Sailaja B Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Chitoor, District, Andhra Pradesh, INDIA. ABSTRACT Viral infections are spreading to a great extent worldwide and affecting and herbal formulations is necessary for assuring therapeutic efficacy, many people. The existing and emerging viral infections are a threat to quality and safety of these preparations. Hence, various standardization human beings. Combating against these viral infections is a challenge methods are developed for ensuring the quality of herbal products. The with the available few antiviral drugs. Though new Antiviral drugs are being current review encompasses the RP- HPLC, LC-MS, GC-MS and HPTLC approved by the FDA every year, controlling emerging viral infections is a methods available for the Single and concurrent estimation of different global concern. The currently available drugs and vaccines for the treatment antiviral phytoconstituents. Key words: Analytical methods, Antiviral Activity, Phytoconstituents. of existing viral infections have limitations. From ancient times, herbs played a significant role in treating viral disorders by developing immunity Correspondence towards viral infections. Some more herbs with their antipyretic and Mrs. B Sivagami analgesic activity helped in treating fever and body aches resulted of viral Associate Professor, Department of Pharmaceutical Analysis, Seven Hills infections. Antiviral phytoconstituents like alkaloids, glycosides, flavonoids, College for Pharmacy, Tirupati-517561, Chittoor, Andhra Pradesh, INDIA. terpenoids, polyphenols, coumarins and saponins of plants have been isolated from plants and studied for their antiviral effects by researchers.
    [Show full text]
  • Natural Antioxidant and Anti-Inflammatory Compounds In
    antioxidants Review Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression 1,2, 3, 4, Dongyup Hahn y, Seung Ho Shin y and Jong-Sup Bae * 1 School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea; [email protected] 2 Department of Integrative Biology, Kyungpook National University, Daegu 41566, Korea 3 Department of Food and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea; [email protected] 4 College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Korea * Correspondence: [email protected] These authors contributed equally to this work. y Received: 29 October 2020; Accepted: 24 November 2020; Published: 27 November 2020 Abstract: Heme oxygenase-1 (HO-1) is an inducible antioxidant enzyme that catalyzes heme group degradation. Decreased level of HO-1 is correlated with disease progression, and HO-1 induction suppresses development of metabolic and neurological disorders. Natural compounds with antioxidant activities have emerged as a rich source of HO-1 inducers with marginal toxicity. Here we discuss the therapeutic role of HO-1 in obesity, hypertension, atherosclerosis, Parkinson’s disease and hepatic fibrosis, and present important signaling pathway components that lead to HO-1 expression. We provide an updated, comprehensive list of natural HO-1 inducers in foodstuff and medicinal herbs categorized by their chemical structures. Based on the continued research in HO-1 signaling pathways and rapid development of their natural inducers, HO-1 may serve as a preventive and therapeutic target for metabolic and neurological disorders.
    [Show full text]
  • Plants of the Genus Zingiber As Source of 3 Antimicrobial Agents: from Tradition to Pharmacy
    Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 16 November 2017 doi:10.20944/preprints201711.0102.v1 1 Review 2 Plants of the Genus Zingiber as Source of 3 Antimicrobial Agents: from Tradition to Pharmacy 4 Mehdi Sharifi-Rad1 , Elena Maria Varoni2, Bahare Salehi3, *, Javad Sharifi-Rad4,*, Karl R. 5 Matthews5, Seyed Abdulmajid Ayatollahi4,6, Farzad Kobarfard4,7, Salam A. Ibrahim8, Dima 6 Mnayer9, Zainul Amiruddin Zakaria10,11, Majid Sharifi-Rad12, Zubaida Yousaf13, Marcello Iriti14,*, 7 Adriana Basile15, Daniela Rigano16,* 8 1Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663-335, Iran; 9 [email protected] 10 2Dipertimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Italy; 11 [email protected] 12 3Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran; 13 [email protected] 14 4Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 15 [email protected] 16 5Department of Food Science, Rutgers University, New Brunswick, NJ 08901, New Jersey, USA; 17 [email protected] 18 6Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences Tehran, 19 Iran; [email protected] 20 7Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 21 Iran; [email protected] 22 8Food Microbiology and Biotechnology Laboratory, 171 Carver Hall, College of Agriculture and 23 Environmental
    [Show full text]