Joint Session with ACOFP and Mayo Clinic: Name That Spell: Diagnosis and Management of Spells

Amy Z. Crepeau, M.D.

9/13/2016

NAME THAT SPELL: DIAGNOSIS AND MANAGEMENT OF SPELLS

Amy Z. Crepeau, M.D. Mayo Clinic Phoenix, Arizona

DISCLOSURES

• None

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OBJECTIVES

• Outline semiologic features of different types. • Discuss the initial work-up to look for evidence of . • Identify additional testing that can be performed to clarify diagnosis of epileptic vs. nonepileptic spells. • Review the utility of ancillary testing to diagnosis nonepileptic spells. • Review data for the treatment of first time seizure.

DEFINITIONS

• Epileptic Seizure • Transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain

• Epilepsy • At least two unprovoked (or reflex) occurring >24 h apart • One unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years • Diagnosis of an epilepsy syndrome

ILAE, 2014

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CASE 1 • A 51 year-old right-handed female is referred to clinic for evaluation of spells. These spells have been occurring over approximately the last year. • At the time of onset, she was under stress due to her daughter’s legal troubles, but otherwise, there was no obvious provoking factor. • She has no history of neurologic illness or injury.

• She reports the spells have been stereotyped in their semiology. • The events begin with a “weird sensation over my body”. This lasts for one minute and either resolves, or progresses such that “I’m just not there”. Her husband reports at this point, she does not speak and seems to be nonresponsive. This may last another minute. She has no recall as to what happens during this time.

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• She has no history of other unusual spells, febrile seizures, CNS infections, significant head traumas or family members with seizures.

• Past medical history is remarkable only for anxiety and depression.

EVALUATING A PATIENT WITH SPELLS

• Description of events • How many types? • Stereotyped or variable? • Warning? • Patient and witness accounts • Are there focal features? • Post-ictal state? • Nocturnal, diurnal, or both? • Triggers? • Frequency • Duration

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• Additional History • Epilepsy risk factors • Febrile seizures • CNS infections • Significant head trauma • Family history of seizures/ epilepsy • Past medical history • Neuroimaging • Prior EEGs

Spells

Seizures Non-epileptic events

Focal Generalized Physiologic Behavioral

Ischemic/ Vascular Cardiac Temporal Autonomic Conversion Extratemporal Sleep Disorder Malingering Multifocal Movement Disorder Panic attacks Migraine Encephalopathy Medication Metabolic

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SEMIOLOGY

• Focal Seizures: Seizure onset zone determines semiology.

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• Temporal Lobe Seizures • Slight female predominance. • Simple partial seizures typically last a few seconds, complex partial seizures are usually longer than 1 minute. • May be have history of febrile seizures in childhood. • Sensory Aura- Olfactory, gustatory hallucinations. Epigastric rising. Auditory hallucinations (likely lateral temporal). • Experiential- Psychic feeling, déjà vu, depersonalization, fear, panic. • Autonomic- Flushing, nausea, pallor. • Aphasia. • Typically followed by postictal confusion, fatigue, with gradual recovery.

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• Frontal Lobe Seizures • Slight male predominance. • Often will have clusters of nocturnal seizures. • Brief in duration, but can quickly secondarily generalize. • May have somatosensory aura, “Jacksonian march”, early posturing or clonic activity, “bicycling”. • May be “hypermotor”- large amplitude, irregular, complex movements. • Autonomic features due to insular involvement. • Orbitofrontal seizures can mimic temporal lobe seizures. • Very brief postical phase.

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• Parietal Lobe Seizures • Aura is typically sensory with tingling or electrical feeling. • Negative sensory feelings consist of numbness or asomatognosia. • Patients may have an urge to move. • Formed visual hallucinations.

• Occipital Lobe Seizures • Visual symptoms- elemental. • Distorted vision. • Migraine?

GENERALIZED SEIZURES

• Generalized Tonic-Clonic • Prodrome may precede seizure by up to 2 days- changes in mood, cognition or perception. • Often begins with ictal cry, immediately into generalized tonic phase. • No consistent head deviation or posturing.

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• Absence • No warning. • Duration under 30 seconds with rapid recovery. • Rarely de novo onset in adults. • Absence status epilepticus can occur in adults, with a predisposition to generalized seizures, in the setting of or alcohol withdrawal, psychotropic drugs.

• Myoclonic Seizures • Single, brief jerks, but often cluster. • May involve any or all limbs, torso. • Typically occur along with other generalized seizures. • Not all is seizure!

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• Tonic • More typically occurs in setting of symptomatic . • Brief, may fall backwards • Atonic • More typically occurs in setting of symptomatic generalized epilepsy. • Head drop, fall forward.

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Spells

Seizures Non-epileptic events

Focal Generalized Physiologic Behavioral

Ischemic/ Vascular Cardiac Temporal Autonomic Conversion Extratemporal Sleep Disorder Malingering Multifocal Movement Disorder Panic attacks Migraine Encephalopathy Medication Metabolic

FEATURES SUGGESTIVE OF NON-EPILEPTIC BEHAVIORAL EVENTS

• Long duration (greater than 3 minutes) • Variable onset • Waxing and waning motor activity • Entire body convulsions with maintained awareness • Eyes closed, with resisted eyelid opening • Opisthotonic posture • Side to side head movements • Nonphysiologic progression • Directly provoked by stressful situations • History of psychiatric disease

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MANAGEMENT OF NONEPILEPTIC BEHAVIORAL EVENTS

• Legitimization of confirmation of NEBE can increase the likelihood of acceptance of the diagnosis. • Explanation needs to be empathetic, positive and non-accusatory. • Selective serotonin reuptake inhibitors may treat underlying co-morbidities of depression and anxiety, but will not fully treat NEBE. • Early AED discontinuation is associated with better outcomes. • Cognitive behavioral therapy has been shown to be beneficial in controlled trials. • Follow- up with the diagnosing physician is important to reinforce the diagnosis and ensure appropriate treatment.

SYNCOPE • Features • Preceded by lightheadedness, dizziness, sweating • White-ing or gray-ing out of vision, a shade coming down • Noted pallor, sweating by witnesses • Eye closure • Variable movements • Relatively rapid recovery • Urinary incontinence does not reliably differentiate from seizure

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• Triggers • Positional change • Physical exertion • Valsalva maneuver • Emotional/ stressful situation • Heat • Dehydration

PARASOMNIAS

• Characterized by vocalization, confusion, may ambulate • Typically lasts a few minutes • Afterwards, patient is confused and amnestic to the event • Events often will be variable

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CEREBROVASCULAR EVENTS

• Symptoms progress over a few seconds to minutes

• Symptoms more likely to be negative- loss of sensation, weakness, visual field deficit

• Duration is minutes to hours

INITIAL EVALUATION

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NEUROIMAGING

• In evaluating indeterminate spells, neuroimaging is performed to look for underlying structural abnormalities which may indicate a seizure focus.

• CT • Readily available, short scanning time. • Able to detect large structural or vascular lesions. • Limited sensitivity for small cortical lesions, mesial temporal structures. • Success of detecting lesions in focal epilepsy is 30.3%.

• MRI • “Gold standard” for imaging in evaluation of epilepsy. • Able to distinguish well between gray and white matter. • Excellent at visualizing mesial temporal structural, cortical abnormalities. • Location of structural abnormalities needs to be correlated with clinical description of events! • 3T increases yield of detecting subtle cortical abnormalities.

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CASE 2

• A 50 year-old gentleman is referred to Epilepsy Clinic by his new primary care physician due to a poorly defined prior history of epilepsy. • The patient reports a life-long history of stereotyped spells. • Events begin with a sensation he is driving quickly down a steep hill, followed by itching of the left palm. His wife reports he has a brief smile and laugh, which is different than his normal, spontaneous laugh. He does not lose awareness. • These can up to 6 times per day. • He has never had a convulsion.

• Seizure risk factors: No history of febrile seizures, CNS infections, significant head trauma, or family members with seizures.

• Medical History significant for Tourette's syndrome.

• Outpatient EEG shows mild, intermittent left hemispheric slowing, no epileptiform activity.

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CASE 3

• A 78 year-old gentleman is referred to Neurology Clinic after a first time seizure.

• The seizure began with left arm jerking, which spread to the left face, and then secondarily generalized. The seizure lasted approximately 90 seconds, and he began responding again after approximately 3 minutes.

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• A significant seizure risk factor is a right middle cerebral artery infarction, which occurred approximately 6 months prior to the seizure. He had residual left sided weakness, dysarthria and dysphagia, and was continuing with outpatient physical therapy.

• Outpatient EEG shows moderate diffuse background slowing, which is maximal over the right hemisphere.

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ELECTROENCEPHALOGRAPHY

• American Academy of Neurology Practice Management Guidelines recommend outpatient EEG as part of the evaluation of an adult with first-time seizure. • 29- 55% of initial EEGs after a first seizure show epileptiform activity. • Epileptiform activity after a first time seizure is associated with seizure recurrence rates of 30-70% at one year.

• The rate of epileptiform activity in healthy volunteers is between 0- 6.6%. • Hyperventilation, photic stimulation and sleep deprivation increase yield of epileptiform activity.

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• Caveats…. • 40% of patients eventually diagnosed with epilepsy will have no epileptiform activity on the initial EEG. • Patients with extratemporal onset focal epilepsy are less likely to have interictal epileptiform discharges. • Occipital spikes have been reported in blind individuals without epilepsy. • First degree of relatives of patients with generalized epilepsy may have generalized epileptiform discharges. • Beware of normal variants which may be confused for epileptiform activity! • Wicket waves • Sawtooth waves • RTTD

CASE 4

• A 19 year-old college student is referred to your clinic for a witnessed generalized tonic-clonic seizure.

• He was in the college gym at the time of the seizure, feeling well, with no recall of an aura. Witnesses report he suddenly made a noise, fell to the ground, and had generalized convulsions lasting approximately 60 seconds. He was confused and amnestic to events for approximately 15 minutes afterwards.

• There were no obvious provoking factors including drug or alcohol use, sleep deprivation or illnesses.

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• In retrospect, he reports a 3 year history of funny spells.

• Spells consisted of a sudden “blood taste” in his mouth, and a feeling as though he was “in his own little world.” Friends had noticed him staring at times. It is unclear if he would lose awareness. These events have occurred nearly daily.

• MRI was performed and was normal.

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ADDITIONAL TESTING CONSIDERATIONS

OUTPATIENT AMBULATORY EEG

• Advantages • Increases yield of epileptiform activity. • Increases yield of capturing habitual event. • Patient is in normal environment, with typical stressors, exposures, etc. • Disadvantages • Variable video availability. • Limited technical quality. • Does not provide a safe environment to taper or discontinue AEDs. • Patient cannot be reliably assessed during event.

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INPATIENT VIDEO EEG MONITORING

• Indications for Video EEG Monitoring • Spell classification • Seizure classification • Seizure localization • Seizure quantification • Medication adjustments under EEG monitoring • Allows for tapering and discontinuation of AEDs in a controlled setting. • Concurrent video, along with real-time clinical assessment, including vital signs, blood work, coincidental medications.

UTILITY OF VIDEO EEG MONITORING

• The yield of diagnosis for paroxysmal spells during admission is up to approximately 80%. • Diagnosis is based upon capturing a typical event or definitive interictal epileptiform activity. • On average, 30% of spells are diagnosed as nonepileptic behavioral events.

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• Physiologic nonepileptic events recorded include ischemia, syncope, sleep disorders and encephalopathy. • Admission results in a change in the diagnosis in 40- 60% of patients. • Approximately 20% of patients admitted for intractable epilepsy ultimately are shown to have nonepileptic events

• Clinical Events without EEG correlate • Nonepileptic events • Very focal seizures without sufficient propagation for scalp correlate (simple partial seizures). • Extratemporal seizures without secondary generalization.

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NEUROPSYCHOMETRIC TESTING

• Provides objective cognitive data which can localize areas of cerebral dysfunction. • Temporal lobe epilepsy more likely to have lateralizing cognitive deficits. • Personality assessments assist in identifying patients with a tendency for somatization. • Validated scales for somatic complaints and conversions correlate with nonepileptic behavioral events.

ADDITIONAL TESTING CONSIDERATIONS

• Cerebrovascular Imaging • Holter Monitor • Arrhythmias • Autonomic Studies/ Tilt Table Test • Orthostatic Hypotension • Postural Orthostatic Tachycardia Syndrome (PoTS) • Autonomic Neuropathy

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• Polysomnography • Parasomnias • Sleep apnea • Movement Disorder Physiologic Study • Myoclonus • Tremor

Spells

Seizures Non-epileptic events

Focal Generalized Physiologic Behavioral

Ischemic/ Vascular Cardiac Temporal Autonomic Conversion Extratemporal Sleep Disorder Malingering Multifocal Movement Disorder Panic attacks Migraine Encephalopathy Medication Metabolic

27 9/13/2016

MANAGEMENT OF FIRST TIME SEIZURE

• AAN Practice Parameters: Management of an unprovoked first seizure in adults, 2015

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• In patients with new- onset seizures, 17- 18% have epileptiform activity on the initial EEG.

• One study found epileptiform activity on initial EEG, is associated with a 10 year risk of seizure recurrence of 76%.

• Relative risk between 1 and 5 years is 2.16 with epileptiform abnormalities on EEG.

Lawn, Epilepsia, 2015 Hauser, Neurology, 1990

WHEN TO TREAT Immediate versus deferred treatment • Immediate treatment significantly reduces the risk of another seizure in the first 2 years (32% vs 39%)

• Number needed to treat= 14

• Long-term seizure control (>5 years) does not differ

Marson, Lancet, 2005 (MRC MESS Study Group)

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Kim, Lancet Neur, 2006 (MRC MESS Study Group)

Kim, Lancet Neur, 2006 (MRC MESS Study Group)

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KEY POINTS • A detailed description of the events and clinical history can assist in determining the likely diagnosis.

• Outpatient EEG and MRI should routinely be used to determine the likelihood of events being seizure.

• When the diagnosis is not clear, video EEG monitoring is the gold standard.

• Consider physiologic causes for nonepileptic events.

• Evaluation of seizure risk factors and additional testing assist in determining the need for anti-epileptic medications after the first seizure.

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