Pharmacokinetics of Veterinary Drugs in Laying Hens and Residues in Eggs: a Review of the Literature
J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2011.01287.x REVIEW ARTICLE Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature V. GOETTING Goetting, V., Lee, K. A., Tell, L. A. Pharmacokinetics of veterinary drugs in K. A. LEE & laying hens and residues in eggs: a review of the literature. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2011.01287.x. L. A. TELL Department of Medicine and Epidemiology, Poultry treated with pharmaceutical products can produce eggs contaminated School of Veterinary Medicine, University with drug residues. Such residues could pose a risk to consumer health. The of California, Davis, CA, USA following is a review of the information available in the literature regarding drug pharmacokinetics in laying hens, and the deposition of drugs into eggs of poultry species, primarily chickens. The available data suggest that, when administered to laying hens, a wide variety of drugs leave detectable residues in eggs laid days to weeks after the cessation of treatment. (Paper received 10 September 2010; accepted for publication 12 February 2011) Lisa A. Tell, Department of Medicine and Epidemiology, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA. E-mail: latell@ucdavis INTRODUCTION from extra-label drug use, then the exposed animal(s) should not enter the food chain unless permission is granted from the proper In poultry, antibiotics and antiparasitics are used extensively for authorities. In both the US and EU, other drugs, including disease prevention and treatment. In the United States, antibiotics chloramphenicol, the nitroimidazoles, and nitrofurans, are are also used for growth promotion, although this type of use has completely prohibited from use in food animals (Davis et al., been prohibited in the European Union since 2006 (Donoghue, 2009; EMEA, 2009).
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