Acta Dermatovenerol Croat 2011;19(1):39-42 REVIEW Drug Induced Psoriasis Višnja Milavec-Puretić, Marko Mance, Romana Čeović, Jasna Lipozenčić Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia Corresponding author: SUMMARY Psoriasis is a chronic inflammatory skin disorder clinically Prof. Višnja Milavec-Puretić, MD, PhD characterized by erythematous, sharply demarcated papules and rounded plaques covered by silvery micaceous scale. While the exact Department of Dermatology and Venereology causes of psoriasis have yet to be discovered, the immune system University Hospital Center Zagreb and genetics are known to play major roles in its development. Many School of Medicine University of Zagreb external factors including infections, stress and medications may ex- acerbate psoriasis. Some of the most common medications know to Šalata 4 trigger or worsen existing psoriasis include lithium, gold salts, beta HR-10000 Zagreb blockers and antimalarials. Exacerbation of psoriasis due to the fol- Croatia lowing medications has also been observed: adrenergic antagonists, [email protected] interferon, gemfibrozil, iodine, digoxin and chlonidine. Having re- viewed a variety of cases, we observed a relationship between cer- tain medications and documented their involvement in exacerbating Received: March 31, 2010 or inducing psoriasis. Accepted: December 29, 2010. KEY WORDS: psoriasis, drug eruption, drug induced psoriasis INTRODUCTION Psoriasis is a chronic inflammatory skin disorder triggers an immune response, which leads to T cell clinically characterized by erythematous, sharply de- activation and release of various cytokines. Co-stimu- marcated papules and rounded plaques covered by latory signals are initiated via interaction of adhesion silvery micaceous scale (1). While the exact causes of molecules on the antigen-presenting cells, such as psoriasis have yet to be discovered, the immune sys- lymphocyte function-associated antigen (LFA)-3 and tem and genetics are known to play major roles in its intercellular adhesion molecule-1, with their respec- development. The immune system is somehow mis- tive receptors CD2 and LFA-1 on T cells. Afterwards, takenly triggered, which speeds up the growth cycle these T cells are released into the circulation and re- of skin cells among other immune reactions (2). Cur- turn to the skin. T cell reactivation in the dermis and rent research suggests that the inflammatory mecha- epidermis and the local effect of cytokines such as nisms are immune based and most likely initiated tumor necrosis factor lead to the inflammation, cell- and maintained primarily by T cells in the dermis (3). mediated immune responses, and epidermal hyperp- Antigen-presenting cells in the skin, such as Langer- roliferation observed in patients with psoriasis. Also, hans cells, are believed to migrate from the skin to re- the interleukin (IL)-12-related cytokine, IL-23, was rec- gional lymph nodes, where they interact with T cells. ognized to be involved in the establishment of chron- Presentation of an as yet unidentified antigen to the ic inflammation and in the development of a T helper T cells, as well as a number of co-stimulatory signals, (Th)-cell subset producing IL-17 (Th17). These cells are ACTA DERMATOVENEROLOGICA CROATICA 39 Milavec-Puretić et al. Acta Dermatovenerol Croat Drug induced psoriasis 2011;19(1):39-42 very distinct from Th1 and Th2 populations and Th17 Table 1. Drugs responsible for the eruption of psoriasis cells are now recognized as a third T-effector cell sub- (11) set. The IL-23/IL-17 pathway has recently been impli- Acebutolol Ketoprofen cated in the induction and progression of a number Acitr patients etin Labetalol of inflammatory diseases, including psoriasis. Genetic Aldesleukin (interleukin 2) Letrozole Alefacept Levamizol factors also seem to have a role in the development Amiodarone Levobetaxolol and course of psoriasis: HLA-B13, -B17, DR7 and -Cw6 Amoxicillin Lithium are all associated with plaque psoriasis. Many fami- Ampicillin Metipranolol lies appear to exhibit autosomal dominant patterns Arpiprazole Modafinil of inheritance with decreased penetrance. Studies of Arsenic Morphine Aspirin Meclofenamate twin siblings have shown concordant disease in 73% Atenolol Mefloquine of monozygotic twins compared with 20% in dizy- Auranofin Mesalamine gotic twins. Several genetic susceptibility loci have Aurotioglucosis Methyltestosterone also been identified, including psoriasis susceptibility Betaxolol Metoprolol Bisoprolol Nadolol 1 (PSOR1) on chromosome 6, which is associated with Botulinum toxin (A & B) Omeprazole up to 50% of cases. Eight other psoriasis susceptibil- Captopril Oral contraceptives ity loci (PSOR2, PSOR3, PSOR4, PSOR5, PSOR6, PSOR7, Carbamazepine Peg interferon PSOR8 and PSOR9) have been discovered, as well as Carteolol Infliximab Carvedilol Penbutolol the transcription factor RUNX1 (4). Celecoxib Penicillamine Extrinsic factors are also important in the patho- Chlorambucil Pentostatin genesis of psoriasis, perhaps as triggers in genetically Chloroquine Perindopril susceptible patients. The role of streptococcal infec- Chlorthalidone Pindolol Cimetidine Potassium iodide tions has been suspected as a triggering factor for Citalopram Primaquine psoriasis for many decades, especially in children and Claritromycin Propranolol guttate forms. The role of streptococcal organisms in Clomipramine Psoralens chronic plaque psoriasis is less certain compared to Clonidine Paroxetine Co-trimoxazole Peginterferon the guttate form (5). Viral infections may also play a Cyclosporin Quinidine role in the etiology of psoriasis, as the eruption ap- Dexfenfluoramine Quinine pears, or the pre-existing disease is aggravated, by Diclofenac Rabeprazol an influenza-type illness. External trauma can induce Digoxin Ranitidine Diltiazem Risperidone local lesions of psoriasis (the Koebner or isomorphic Dipyridamole Ritonavir phenomenon) (6). Patients frequently complain that Diphenylhydatonin Rivastigmine psychological stress causes flares of psoriasis activ- Doxycycline Rofecoxib ity. Review of the literature suggests that stress from Doxorubicin Ropinirol major life events, and some personality traits such Efalizumab Saquinavir Eletriptan Sotalol as difficulty in expressing emotion, may play a role Enalapril Sodium chromoglycate in psoriasis (7). It is not known how stress induces or Esmolol Sulfamethoxazole aggravates psoriasis. Stress has effects on hormones, Etanercept Sulfasalazine and on the autonomic nervous and immune systems. Flecainide Sulfazolamine Fluorouracil Tacrine There is some evidence that psoriasis is associated Fluoxetine Terbinafine with a number of diseases strongly linked to alcohol Fluoxymesterone Terfenadine consumption and smoking (8,9). Foscarnet Testosterone Gancyclovir Tetracycline Many drugs have also been suspected to trig- Gemfibrozil Thalidomide ger psoriasis (10). There have been many medica- Glimepride Thiabendazole tions documented to directly cause the eruption of Glatiramer Thioguanine psoriasis (Table 1), along with others that have been Glipizide Tiagabine documented to induce psoriasis (Table 2). How these Glyburide Timolol Gold Trazodone different drugs with different chemical structures can Granulocyte colony-stimulating Ursodiol have the same effect is difficult to explain; they may factor (GCSF) Valdecoxib affect the psoriatic process at different stages but Henna Valproic acid with the same results. Hydroxyurea Venlafaxine Ibuprofen Voriconazole It is evident by the large number of associated Interferon alfa-2 Zaleplon medications linked to psoriasis seen in Tables 1 and 2 Interferon beta-1b that a great deal of thought and care must be invest- JZ Litt: Psoriasis. Drug eruption reference manual 2006:643. 40 ACTA DERMATOVENEROLOGICA CROATICA Milavec-Puretić et al. Acta Dermatovenerol Croat Drug induced psoriasis 2011;19(1):39-42 Table 2. Drugs responsible for the induction of psoriasis cases (20). In patients taking antipsychotic medica- (11) tions, Brauchli et al. found that between the identi- Acetazolamide Diclofenac fied 36,702 incident cases of psoriasis and the same Aminoglutethimide Diltiazem number of matched controls the use of 5 or more prescriptions for lithium and atypical antipsychot- Amiodarone Hydroxychloroquine ics yielded adjusted odds ratios (OR) of 1.68 (95% CI, Amoxicillin Indomethacin 1.18-2.39; P<0.01) and 0.76 (95% CI, 0.55-1.06; P=0.11), Ampicillin Lithium respectively. They also found that the OR for olanzap- Aspirin Methicillin ine was 0.50 (95% CI, 0.28-0.89, P=0.02), suggesting Atenolol Penicillins that long-term use of lithium was associated with a Chloroquine Potassium iodide small increase in the risk of incident psoriasis, while Cimetidine Propranolol there is a suggestion of a possible reduced psoriasis risk associated with the use of atypical antipsychot- Corticosteroids Terbinafine ics, mainly olanzapine (21). Bisoprolol, a commonly Cyclosporin used beta blocker, was found by Waqar and Sarkar to Litt JZ: Psoriasis. Drug eruption reference manual 2006:645. cause acute worsening of psoriasis within 72 hours of being prescribed in one of their patients (22). Thakor et al. documented the first reported case of ramipril- ed by the physician when choosing the appropriate induced psoriasis, which reminds us of the impor- therapy for patients. There is always a potential risk tance of recognizing new medications as the possible when prescribing