United States Patent ( 10) Patent No
US010328026B2 (12 ) United States Patent ( 10 ) Patent No. : US 10 , 328 , 026 B2 Thaxton et al. (45 ) Date of Patent: * Jun . 25 , 2019 ( 54 ) SYNTHETIC NANOSTRUCTURES (58 ) Field of Classification Search INCLUDING NUCLEIC ACIDS AND /OR CPC .. .. .. .. A61K 9 / 127 OTHER ENTITIES See application file for complete search history . (71 ) Applicant: Northwestern University, Evanston , IL (56 ) References Cited (US ) U . S . PATENT DOCUMENTS (72 ) Inventors : C . Shad Thaxton , Chicago , IL (US ) ; 5 ,472 , 881 A 12 / 1995 Beebe et al. Chad A . Mirkin , Wilmette , IL ( US) ; 5 , 814 ,666 A 9 / 1998 Green et al . Kaylin M . McMahon , Chicago , IL 5 , 955 , 589 A 9 / 1999 Cook et al. (US ) ; Sushant Tripathy , Evanston , IL 6 , 274 , 337 B1 8 / 2001 Parce et al. (US ) ; Raja Kannan Mutharasan , 6 , 361, 944 B1 3 / 2002 Mirkin et al. 6 ,506 , 564 B1 1 / 2003 Mirkin et al. Chicago , IL ( US ) ; David M . Leander , 6 ,677 , 153 B2 1 / 2004 Iversen St. Louis , MO (US ) ; Andrea Luthi, 7 ,691 , 414 B2 4 / 2010 Sligar et al. Evanston , IL (US ) 7 , 951 ,453 B25 / 2011 Debertret et al . 8 ,323 ,686 B2 * 12/ 2012 Mirkin .. A61K 9 / 1275 424 / 450 ( 73 ) Assignee : Northwestern University, Evanston , IL 8 ,933 ,046 B2 1 / 2015 Machuy et al . (US ) 9 , 216 , 155 B2 8 /2015 Thaxton et al. 9 , 532 , 948 B2 1 / 2017 Mirkin et al. ( * ) Notice: Subject to any disclaimer , the term of this 9 ,693 , 957 B2 7 / 2017 Lin et al. patent is extended or adjusted under 35 2003 /0147966 AL 8 / 2003 Franzen et al .
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